Publications by authors named "Wentao Li"

326 Publications

General molten-salt route to three-dimensional porous transition metal nitrides as sensitive and stable Raman substrates.

Nat Commun 2021 Mar 2;12(1):1376. Epub 2021 Mar 2.

Institute of Industrial and Consumer Product Safety, Chinese Academy of Inspection and Quarantine, Beijing, P. R. China.

Transition metal nitrides have been widely studied due to their high electrical conductivity and excellent chemical stability. However, their preparation traditionally requires harsh conditions because of the ultrahigh activation energy barrier they need to cross in nucleation. Herein, we report three-dimensional porous VN, MoN, WN, and TiN with high surface area and porosity that are prepared by a general and mild molten-salt route. Trace water is found to be a key factor for the formation of these porous transition metal nitrides. The porous transition metal nitrides show hydrophobic surface and can adsorb a series of organic compounds with high capacity. Among them, the porous VN shows strong surface plasmon resonance, high conductivity, and a remarkable photothermal conversion efficiency. As a new type of corrosion- and radiation-resistant surface-enhanced Raman scattering substrate, the porous VN exhibits an ultrasensitive detection limit of 10 M for polychlorophenol.
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http://dx.doi.org/10.1038/s41467-021-21693-4DOI Listing
March 2021

All-Solution-Processed Multilayered White Polymer Light-Emitting Diodes (WPLEDs) Based on Cross-Linked [Ir(4-vb-PBI)(acac)].

ACS Appl Mater Interfaces 2021 Mar 1. Epub 2021 Mar 1.

Department of Chemistry & Biochemistry, Eastern Illinois University, Charleston, Illinois 61920, United States.

All-solution-processed multilayered white polymer light-emitting diodes (WPLEDs) are promising candidates for low-cost and large-area flexible full-color flat-panel displays and solid-state lighting. However, it is still challenging to improve their performance. In this work, based on an elegant strategy of orthogonal materials, the utilization of the cross-linked Ir polymer film ( = -vinyl-carbazole; = 1-(4-vinylbenzyl)-2-phenyl-1-benzo[]imidazole; and = acetylacetone) as the emitting layer (EML) between a hydrophilic polymer film poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) () as the hole injection layer (HIL) and a hydrophobic polymer film ( = 2-(4-(-butyl)phenyl)-5-(4'-vinyl-[1,1'-biphenyl]-4-yl)-2,5-dihydro-1,3,4-oxadiazole) as the electron transport layer (ETL) led to the successful fabrication of reliable all-solution-processed multilayered WPLEDs. The device exhibits a η of 18.19 cd/A, a η of 8.16 lm/W, and a η of 9.32% with stable white light (Commission International De L'Eclairage (CIE) coordinates = 0.269-0.283, = 0.317-0.330; corrected color temperatures (CCTs) of 7237-8199 K, and CRIs (color rendering indices) of 63-72) under a wide applied-voltage range. Its high performance, especially with record efficiencies among those of reported all-solution-processed WPLEDs, renders cross-linked Ir polymers a new platform to all-solution-processed multilayered WPLEDs.
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http://dx.doi.org/10.1021/acsami.0c16581DOI Listing
March 2021

Adipose triglyceride lipase promotes the proliferation of colorectal cancer cells via enhancing the lipolytic pathway.

J Cell Mol Med 2021 Feb 23. Epub 2021 Feb 23.

Department of Clinical Laboratory, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Abnormal lipid metabolism is the sign of tumour cells. Previous researches have revealed that the lipolytic pathway may contribute to the progression of colorectal cancer (CRC). However, adipose triglyceride lipase (ATGL) role in CRC cells remains unclear. Here, we find that elevated ATGL positively correlates with CRC clinical stages and negatively associates with overall survival. Overexpression of ATGL significantly promotes CRC cell proliferation, while knockdown of ATGL inhibits the proliferation and promotes the apoptosis of CRC cells in vitro. Moreover, in vivo experiments, ATGL promotes the growth of CRC cells. Mechanistically, ATGL enhances the carcinogenic function of CRC cells via promoting sphingolipid metabolism and CoA biosynthesis pathway-related gene levels by degrading triglycerides, which provides adequate nutrition for the progression of CRC. Our researches clarify for the first time that ATGL is a novel oncogene in CRC and may provide an important prognostic factor and therapeutic target for CRC.
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http://dx.doi.org/10.1111/jcmm.16349DOI Listing
February 2021

Tracing the Path Toward Self-Regulated Revision: An Interplay of Instructor Feedback, Peer Feedback, and Revision Goals.

Front Psychol 2020 5;11:612088. Epub 2021 Feb 5.

School of Foreign Languages, Northeast Normal University, Changchun, China.

Building upon Zimmerman's socio-cognitive view of self-regulation, we explored EFL (English as a Foreign Language) students' revision and the likely contribution to revision from three salient self-regulating sources: peer feedback, instructor feedback, and revision goals. Data was obtained from 70 Chinese EFL students in a writing class through a 300-word online writing assignment involving online instructor and peer feedback, free-response revision goals, and a required revision. We closely coded students' revision and then used the same coding scheme to analyze the relative levels of association of revision changes with peer comments, instructor comments and revision goals. We found that: (a) the majority of revision changes have been triggered by three mediating sources, with revision goals as the most significant contributing source. Additionally, most revision changes come from a combination of two or three sources, with the overlap of peer feedback and revision goals accounting for the biggest overlapping contribution for both high and low-level revisions; (b) as for the relationship among the three sources, no significant difference was found between revision goals' overlap rate with peer feedback and their overlap rate with instructor feedback. Instructor feedback and peer feedback did not overlap very much. Findings suggest that students could revise beyond instructor and peer feedback in their revision efforts guided by their own reflective goals, and peer feedback could function as a more productive and multiple-reader source of revision in comparison with instructor feedback. This study also provided evidence for students' self-regulated learning of writing through the use of self-regulating resources and charted a route for how writing could be improved.
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http://dx.doi.org/10.3389/fpsyg.2020.612088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892436PMC
February 2021

A new global potential energy surface of the SH(XA'') system and quantum calculations for the S + H( = 0-3, = 0) reaction.

Phys Chem Chem Phys 2021 Mar;23(8):4757-4767

Shandong Peninsula Engineering Research Center of Comprehensive Brine Utilization and Key Laboratory for Structure and Environment Disaster Preventing of Agriculture Greenhouse, Weifang University of Science and Technology, Shouguang, 262700, People's Republic of China.

A new global potential energy surface (PES) for the ground state of the SH2+(X4A'') system is constructed using a permutation invariant polynomial neural network method. In ab initio calculations, the MRCI-F12 method with the AVTZ basis set is used. Furthermore, the dynamics calculations of the S+ + H2(v = 0-3, j = 0) → SH+ + H reaction are carried out based on the new PES. The reaction probabilities and integral cross sections are compared with available theoretical calculations. Present values are in general good agreement with the previous theoretical studies. However, some discrepancies can still be found due to different PESs used in the calculation. Furthermore, the vibrational energy of the reactant molecule can significantly enhance the reactivity compared to the translational energy. The differential cross sections indicated that the reaction mechanism is changed from the "head-on" rebound mechanism to the tripping mechanism with the increasing number of initial vibrational excitation state.
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http://dx.doi.org/10.1039/d0cp06335eDOI Listing
March 2021

Haemostatic and thrombo-embolic complications in pregnant women with COVID-19: a systematic review and critical analysis.

BMC Pregnancy Childbirth 2021 Feb 5;21(1):108. Epub 2021 Feb 5.

Division of Child Health, Obstetrics and Gynaecology, School of Medicine, University of Nottingham, Nottingham, UK.

Background: As pregnancy is a physiological prothrombotic state, pregnant women may be at increased risk of developing coagulopathic and/or thromboembolic complications associated with COVID-19.

Methods: Two biomedical databases were searched between September 2019 and June 2020 for case reports and series of pregnant women with a diagnosis of COVID-19 based either on a positive swab or high clinical suspicion where no swab had been performed. Additional registry cases known to the authors were included. Steps were taken to minimise duplicate patients. Information on coagulopathy based on abnormal coagulation test results or clinical evidence of disseminated intravascular coagulation (DIC), and on arterial or venous thrombosis, were extracted using a standard form. If available, detailed laboratory results and information on maternal outcomes were analysed.

Results: One thousand sixty-three women met the inclusion criteria, of which three (0.28, 95% CI 0.0 to 0.6) had arterial and/or venous thrombosis, seven (0.66, 95% CI 0.17 to 1.1) had DIC, and a further three (0.28, 95% CI 0.0 to 0.6) had coagulopathy without meeting the definition of DIC. Five hundred and thirty-seven women (56%) had been reported as having given birth and 426 (40%) as having an ongoing pregnancy. There were 17 (1.6, 95% CI 0.85 to 2.3) maternal deaths in which DIC was reported as a factor in two.

Conclusions: Our data suggests that coagulopathy and thromboembolism are both increased in pregnancies affected by COVID-19. Detection of the former may be useful in the identification of women at risk of deterioration.
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http://dx.doi.org/10.1186/s12884-021-03568-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7863033PMC
February 2021

Highly Sensitive WO Mesocrystal Raman Scattering Substrate with Large-Area Signal Uniformity.

Anal Chem 2021 Feb 1;93(6):3138-3145. Epub 2021 Feb 1.

Institute of Industrial and Consumer Product Safety, Chinese Academy of Inspection and Quarantine, No. 11, Ronghua South Road, Beijing 100176, P. R. China.

Although mesocrystals with ordered building units have great potential in many fields because of the large amount of organic molecules used as structure-directing agents during their synthesis process, severe matrix interference makes their surface-enhanced Raman scattering (SERS) properties rarely understood. Herein, a rapid (20 s) and green microwave synthetic route is developed for the 100 g scale preparation of plasmonic WO mesocrystals with no additives. The ultrathin (1.5 nm) and oxygen vacancy-rich WO nanowires as a building unit greatly improve the interface charge transfer, while the periodic mesocrystal structure significantly enhances the localized surface plasmon resonance effect and creates high-density electromagnetic hot spots among the nanowires. An outstanding enhancement factor of 1.2 × 10 and an ultralow detectable limit of 10 M are achieved, and the single-molecule imaging is also realized on this mesocrystal-based SERS substrate. Moreover, the relative standard deviation of the fabricated large-area (2.2 cm) SERS substrate is only 6.8%.
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http://dx.doi.org/10.1021/acs.analchem.0c04516DOI Listing
February 2021

Diagnostic Accuracy of Transvaginal Ultrasound and Magnetic Resonance Imaging for Adenomyosis: Systematic Review and Meta-Analysis and Review of Sonographic Diagnostic Criteria.

J Ultrasound Med 2021 Jan 27. Epub 2021 Jan 27.

Monash Women's, Monash Medical Centre, Monash Health, Clayton, Victoria, Australia.

We aim to first systematically review and perform a meta-analysis of the diagnostic accuracy of transvaginal ultrasound (TVUS) and magnetic resonance imaging (MRI) and, second, to evaluate the accuracy of various sonographic diagnostic criteria for adenomyosis. A search of PubMed and Embase yielded 32 eligible studies. In diagnosing adenomyosis, the diagnostic performance of TVUS was found to be high and comparable to the performance of MRI. Of the eight sonographic criteria, only five were assessable. The best individual criterion was echogenic subendometrial lines and buds. Limited data exist for the various sonographic criteria, and further studies are required to compare their performance.
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http://dx.doi.org/10.1002/jum.15635DOI Listing
January 2021

Authors' reply re: Maternal transmission of SARS-COV-2 to the neonate, and possible routes for such transmission: a systematic review and critical analysis.

BJOG 2021 03 28;128(4):769. Epub 2020 Dec 28.

Division of Child Health, Obstetrics and Gynaecology, School of Medicine, University of Nottingham, Nottingham, UK.

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http://dx.doi.org/10.1111/1471-0528.16436DOI Listing
March 2021

Bifunctional, Copper-Doped, Mesoporous Silica Nanosphere-Modified, Bioceramic Scaffolds for Bone Tumor Therapy.

Front Chem 2020 9;8:610232. Epub 2020 Dec 9.

Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

In the traditional surgical intervention procedure, residual tumor cells may potentially cause tumor recurrence. In addition, large bone defects caused by surgery are difficult to self-repair. Thus, it is necessary to design a bioactive scaffold that can not only kill residual tumor cells but also promote bone defect regeneration simultaneously. Here, we successfully developed Cu-containing mesoporous silica nanosphere-modified β-tricalcium phosphate (Cu-MSN-TCP) scaffolds, with uniform and dense nanolayers with spherical morphology 3D printing and spin coating. The scaffolds exhibited coating time- and laser power density-dependent photothermal performance, which favored the effective killing of tumor cells under near-infrared laser irradiation. Furthermore, the prepared scaffolds favored the proliferation and attachment of rabbit bone marrow-derived mesenchymal stem cells and stimulated the gene expression of osteogenic markers. Overall, Cu-MSN-TCP scaffolds can be considered for complete eradication of residual bone tumor cells and simultaneous healing of large bone defects, which may provide a novel and effective strategy for bone tumor therapy. In the future, such Cu-MSN-TCP scaffolds may function as carriers of anti-cancer drugs or immune checkpoint inhibitors in chemo-/photothermal or immune-/photothermal therapy of bone tumors, favoring for effective treatment.
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http://dx.doi.org/10.3389/fchem.2020.610232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7755992PMC
December 2020

Effect of straw and inhibitors on the fate of nitrogen applied to paddy soil.

Sci Rep 2020 12 9;10(1):21582. Epub 2020 Dec 9.

Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang, 110016, People's Republic of China.

A pot experiment was used to explore the distribution of fertilizer N and agronomic effects in a paddy soil-rice (Oryza sativa L.) system. Five treatments were set: without nitrogen, straw and inhibitor (C), urea (U), urea + straw (US), urea + urease + nitrification inhibitor (UI) and urea + urease + nitrification inhibitor + straw (UIS). Soil and urea-derived microbial biomass N increased significantly in US and UIS compared with straw-free treatments at seedling and tillering, indicating that biotic process play an important role in the retention of fertilizer N with straw addition. About 10% urea-N was recovered as fixed ammonium (FA) at seedling stage, subsequently released at tillering and maturation regardless of treatments, which emphasizes the importance of FA in the retention and supply of fertilizer N in paddy soils. Compared with U, rice yield and N uptake in US decreased by 7.8% and 25.2% respectively, while inhibitors (UIS) alleviated the reduction by 16.4% and 31.6%. The current research indicated UIS is recommended as the most appropriate management strategy in paddy soils of Northeast China based on N dynamics. But the economic effect as well as the field-scale validation need to be further evaluated.
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http://dx.doi.org/10.1038/s41598-020-78648-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725816PMC
December 2020

Carbonating MgO for treatment of manganese- and cadmium-contaminated soils.

Chemosphere 2021 Jan 11;263:128311. Epub 2020 Sep 11.

School of Civil and Environmental Engineering, Nanyang Technological University, 639798, Singapore. Electronic address:

Ordinary Portland cement (OPC) and lime are commonly used to treat soils contaminated by heavy metals, such as cadmium (Cd) and manganese (Mn). However, the production of these two binders is not sustainable, consuming high energy and emitting high carbon dioxide (CO). In this contest, this study proposed a novel and sustainable method of carbonating magnesia (MgO) for treatment of Cd- and Mn-contaminated soils, which can sequester CO and immobilize Cd and Mn in the soils. To validate the method, a range of experiments were performed. First, MgO and CO were used to treat contaminated soils. Then, the properties of the treated soils were evaluated by unconfined compressive strength test, one stage batch leaching test, X-ray diffraction test, and thermogravimetric analysis. It was found that the carbonation process of MgO-treated soils was decelerated by Mn, but not significantly decelerated by Cd. After carbonation, multiple magnesium carbonates were formed in both contaminated soils, and CdCO was formed in the Cd-contaminated soil, while MnCO was not confidently determined in the Mn-contaminated soil. Both Cd and Mn negatively affected the strength of carbonated MgO-treated soils; nevertheless, if the concentration of Cd or Mn was not more than 8000 mg/kg, 5% MgO-treated soils after carbonation could meet the strength requirement of higher than 1000 kPa. The treatment decreased the Cd leachability to be below the limit for non-hazardous wastes. The leached concentration of Mn was decreased to be lower than the limit of drinking water.
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http://dx.doi.org/10.1016/j.chemosphere.2020.128311DOI Listing
January 2021

Older adults lack SARS CoV-2 cross-reactive T lymphocytes directed to human coronaviruses OC43 and NL63.

Sci Rep 2020 12 8;10(1):21447. Epub 2020 Dec 8.

Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine, Bünteweg 17, 30559, Hannover, Germany.

Currently, infections with SARS-Coronavirus-2 (SARS-CoV-2), the causative agent of the COVID-19 pandemic, are responsible for substantial morbidity and mortality worldwide. Older adults subjects > 60 years of age account for > 95% of the over one million fatal cases reported to date. It is unclear why in this age group SARS-CoV-2 infection causes more severe disease than in young adults. We hypothesized that differences in SARS-CoV-2 cross-reactive cellular immunity induced after infection with human coronaviruses (HCoVs), like OC43 and NL63, were at the basis of the differential mortality (and morbidity) observed after SARS-CoV-2 infection, because a small proportion of HCoV-specific T cells cross-react with SARS-CoV-2. Our data demonstrate that pre-existing T cell immunity induced by circulating human alpha- and beta-HCoVs is present in young adult individuals, but virtually absent in older adult subjects. Consequently, the frequency of cross-reactive T cells directed to the novel pandemic SARS-CoV-2 was minimal in most older adults. To the best of our knowledge, this is the first time that the presence of cross-reactive T cells to SARS-CoV-2 is compared in young and older adults. Our findings provide at least a partial explanation for the more severe clinical outcome of SARS-CoV-2 infection observed in the elderly. Moreover, this information could help to design efficacious vaccines for this age group, aiming at the induction of cell-mediated immunity.
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http://dx.doi.org/10.1038/s41598-020-78506-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7722724PMC
December 2020

Vitamin D supplementation prior to in vitro fertilisation in women with polycystic ovary syndrome: a protocol of a multicentre randomised, double-blind, placebo-controlled clinical trial.

BMJ Open 2020 12 8;10(12):e041409. Epub 2020 Dec 8.

Department of Reproductive Endocrinology, Key Laboratory of Reproductive Genetics, Ministry of Education, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China

Introduction: Polycystic ovary syndrome (PCOS) is one of the leading causes of female infertility, affecting around 5% of women of childbearing age in China. Vitamin D insufficiency is common in women with PCOS and is associated with lower live birth rates. However, evidence regarding the effectiveness of vitamin D supplementation in women with PCOS is inconclusive. This multicentre randomised, double-blinded, placebo-controlled trial aims to evaluate the effectiveness of vitamin D supplementation prior to in vitro fertilisation (IVF) on the live birth rate in women with PCOS.

Methods And Analysis: We plan to enrol women with PCOS scheduled for IVF. After informed consent, eligible participants will be randomised in a 1:1 ratio to receive oral capsules of 4000 IU vitamin D per day or placebo for around 12 weeks until the day of triggering. All IVF procedures will be carried out routinely in each centre. The primary outcome is live birth after the first embryo transfer. The primary analysis will be by intention-to-treat analysis. To demonstrate or refute that treatment with vitamin D results in a 10% higher live birth rate than treatment with placebo, we need to recruit 860 women (48% vs 38% difference, anticipating 10% loss to follow-up and non-compliance, significance level 0.05 and power 80%).

Ethics And Dissemination: This study has been approved by the Ethics Committee in Women's Hospital of Zhejiang University on 2 March 2020 (reference number: IRB-20200035-R). All participants will provide written informed consent before randomisation. The results of the study will be submitted to scientific conferences and a peer-reviewed journal.

Trial Registration Number: NCT04082650.
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http://dx.doi.org/10.1136/bmjopen-2020-041409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725097PMC
December 2020

Biomarkers and the Prediction of Adverse Outcomes in Preeclampsia: A Systematic Review and Meta-analysis.

Obstet Gynecol 2021 Jan;137(1):72-81

Department of Obstetrics and Gynaecology, Monash University, Monash Medical Centre, and Monash Women's, Monash Health, Clayton, Melbourne, Australia; and the Aberdeen Centre for Women's Health Research, Institute of Applied Health Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, United Kingdom.

Objective: To systematically review the performance of soluble fms-like tyrosine kinase-1 (sFlt-1), placental growth factor (PlGF), and the sFlt-1/PlGF ratio in predicting adverse outcomes in women with preeclampsia.

Data Sources: We performed a systematic search of MEDLINE, EMBASE, CINAHL, Cochrane, Scopus, ClinicalTrials.gov, and Emcare databases from 1989 to March 2019 to identify studies correlating sFlt-1, PlGF, and the sFlt-1/PlGF ratio with the occurrence of adverse outcomes in women with preeclampsia.

Methods Of Study Selection: Two independent reviewers screened 3,194 studies using Covidence. Studies were included if they examined the performance of sFLT-1, PlGF, or the sFLT-1/PlGF ratio in predicting adverse outcomes in women with suspected or confirmed preeclampsia.

Tabulation, Integration, And Results: We extracted contingency tables with true-positive, false-positive, true-negative, and false-negative results. We calculated sensitivity, specificity, diagnostic odds ratios, and area under the summary receiver operating characteristic curve (area sROC) through a bivariate mixed-effects meta-analysis. Our literature search identified 3,194 articles, of which 33 (n=9,426 patients) were included. There was significant variation in the included studies with regard to the biomarkers and outcomes assessed. As such, few studies (n=4-8) were included in the meta-analysis component with significant heterogeneity between studies (I2=33-99). Nonetheless, both PlGF and the sFlt-1/PlGF ratio demonstrated area sROC values between 0.68 and 0.87 for the prediction of composite adverse maternal and perinatal outcomes, preterm birth and fetal growth restriction.

Conclusion: Placental growth factor and the sFlt-1/PlGF ratio show prognostic promise for adverse outcomes in preeclampsia, but study heterogeneity limits their clinical utility.

Systematic Review Registration: PROSPERO, CRD42019136207.
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http://dx.doi.org/10.1097/AOG.0000000000004149DOI Listing
January 2021

Embryo incubation by time-lapse systems versus conventional incubators in Chinese women with diminished ovarian reserve undergoing IVF/ICSI: a study protocol for a randomised controlled trial.

BMJ Open 2020 11 14;10(11):e038657. Epub 2020 Nov 14.

Centre for Reproductive Medicine, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China

Introduction: The time-lapse imaging system (TLS) is a newly developed non-invasive embryo assessment system. Compared with conventional incubators, a TLS provides stable culture conditions and consistent observations of embryo development, thereby potentially improving embryo quality and selection of the best quality embryo. Although TLSs have been routinely used in many in vitro fertilisation (IVF) centres globally, there is insufficient evidence to indicate that TLSs result in higher cumulative live birth rates over conventional incubators. The purpose of this study is to compare the cumulative live birth rates and safety including miscarriage in infertile patients with diminished ovarian reserve (DOR) from both TLSs and conventional incubators.

Methods And Analysis: This study is a double-blind randomised controlled clinical trial (1:1 treatment ratio of TLSs vs conventional incubator). A total of 730 patients with DOR undergoing the first or second cycle of IVF or intracytoplasmic sperm injection (ICSI) will be enrolled and randomised into two parallel groups. Participants will undergo embryo culture in the TLSs (group A) or the conventional incubators (group B), respectively. Embryos are selected for transfer in both groups by the morphological characteristics. The embryo selection algorithm software is not used in the TLSs. The primary outcome is the cumulative live birth rate of the trial IVF/ICSI cycle within 12 months after randomisation. This study is powered to detect an absolute difference of 10% (35% vs 25%) at the significance level of 0.05% and 80% statistical power based on a two-sided test.

Ethics And Dissemination: This trial has been approved by the Institutional Ethical Committee of Shanghai First Maternity and Infant Hospital (KS1958). All participants in the trial will provide written informed consent. The study will be conducted according to the principles outlined in the Declaration of Helsinki and its amendments. Results of this study will be disseminated in peer-reviewed scientific journals.

Trial Registration Number: Chinese Clinical Trial Registry (ChiCTR1900027746).
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http://dx.doi.org/10.1136/bmjopen-2020-038657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7668367PMC
November 2020

Can the use of diagnostic and prognostic categorisation tailor the need for assisted reproductive technology in infertile couples?

Aust N Z J Obstet Gynaecol 2020 Nov 2. Epub 2020 Nov 2.

Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.

Background: The complications associated with in vitro fertilisation (IVF) for both the offspring and mother, and its high cost make it essential to tailor the technology to those infertile couples who truly benefit from it.

Aims: To determine whether a simple prognostic algorithm could discriminate between couples who require immediate fertility treatments and couples in whom less invasive strategies should be offered first.

Materials And Methods: In this retrospective cohort study, couples were classified into six groups based on the medical necessity of IVF and their prognosis for natural conception: (i) tubal/severe semen factor mandating immediate IVF due to the very low chance of natural conception; (ii) pure anovulation infertility; (iii) female age ≥39 years; and (iv) unexplained/mild male infertility (no indication for immediate treatment) with (4A) good, (4B) moderate or (4C) poor prognosis of natural conception, as per an existing, validated prognostic model. For each group, we constructed Kaplan-Meier curves to measure natural conception and the effect of fertility treatment.

Results: The 12 months cumulative live birth rate for couples with unexplained or mild male infertility and poor prognosis increased from 1% without treatment to 35% after treatment (P < 0.001). In contrast, couples with good prognosis experienced a statistically insignificant increase in their cumulative live birth rate from 40% to 56% (P = 0.07). This demonstrates that a prognostic model could predict a couple's chances of natural conception and the benefit they derive from treatment.

Conclusions: This prognostic mode allows fertility treatment to be individually tailored to reduce unnecessary IVF without compromising fertility chances.
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http://dx.doi.org/10.1111/ajo.13273DOI Listing
November 2020

Development of a SARS-CoV-2 Total Antibody Assay and the Dynamics of Antibody Response over Time in Hospitalized and Nonhospitalized Patients with COVID-19.

J Immunol 2020 12 30;205(12):3491-3499. Epub 2020 Oct 30.

Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, 1066 CX Amsterdam, the Netherlands;

Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 infections often cause only mild disease that may evoke relatively low Ab titers compared with patients admitted to hospitals. Generally, total Ab bridging assays combine good sensitivity with high specificity. Therefore, we developed sensitive total Ab bridging assays for detection of SARS-CoV-2 Abs to the receptor-binding domain (RBD) and nucleocapsid protein in addition to conventional isotype-specific assays. Ab kinetics was assessed in PCR-confirmed, hospitalized coronavirus disease 2019 (COVID-19) patients ( = 41) and three populations of patients with COVID-19 symptoms not requiring hospital admission: PCR-confirmed convalescent plasmapheresis donors ( = 182), PCR-confirmed hospital care workers ( = 47), and a group of longitudinally sampled symptomatic individuals highly suspect of COVID-19 ( = 14). In nonhospitalized patients, the Ab response to RBD is weaker but follows similar kinetics, as has been observed in hospitalized patients. Across populations, the RBD bridging assay identified most patients correctly as seropositive. In 11/14 of the COVID-19-suspect cases, seroconversion in the RBD bridging assay could be demonstrated before day 12; nucleocapsid protein Abs emerged less consistently. Furthermore, we demonstrated the feasibility of finger-prick sampling for Ab detection against SARS-CoV-2 using these assays. In conclusion, the developed bridging assays reliably detect SARS-CoV-2 Abs in hospitalized and nonhospitalized patients and are therefore well suited to conduct seroprevalence studies.
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http://dx.doi.org/10.4049/jimmunol.2000767DOI Listing
December 2020

Safety and diagnostic accuracy of percutaneous CT-guided transthoracic biopsy of small lung nodules (≤20 mm) adjacent to the pericardium or great vessels.

Diagn Interv Radiol 2021 Jan;27(1):94-101

Department of Interventional Radiology, Fudan University Shanghai Cancer Center, Shanghai, China.

Purpose: We aimed to evaluate the safety and diagnostic accuracy of computed tomography (CT)-guided transthoracic biopsy of small lung nodules (≤20 mm) adjacent to the pericardium or great vessels.

Methods: This retrospective study examined the safety and diagnostic accuracy of percutaneous CT-guided biopsy for small lung nodules (≤20 mm) located within 10 mm of the pericardium or great vessels. Technical aspects and factors influencing complications were assessed, and diagnostic accuracy was calculated.

Results: A total of 168 biopsies were performed in 168 patients. The complications were mainly pneumothorax (34.5%; 58 of 168 patients), chest tube insertion (5.3%; 9 of 168 patients), and pulmonary hemorrhage (61.3%; 103 of 168 procedures), with no patient mortality. One patient (0.6%) was admitted because of hemorrhage complications. Significant independent risk factors for pneumothorax were nodules resided in upper or middle lobes and lateral patient position, and for hemorrhage, longer distance from structures and longer needle trajectory through the lung parenchyma. Overall, the sensitivity, accuracy, and specificity were 91.0%, 92.2%, and 100%, respectively.

Conclusion: Percutaneous CT-guided transthoracic biopsy was highly accurate in small lung nodules (≤20 mm) adjacent to the pericardium or great vessels. Complications are common, but most were minor and self-limited.
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http://dx.doi.org/10.5152/dir.2020.20051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837726PMC
January 2021

The Role of Glutamate in Language and Language Disorders - Evidence from ERP and Pharmacologic Studies.

Neurosci Biobehav Rev 2020 12 9;119:217-241. Epub 2020 Oct 9.

Department of Neurology, University of California, Davis, 4860 Y Street, Suite 3700, Sacramento, CA, 95817, USA; Center for Mind and Brain, University of California, Davis, 267 Cousteau Place, Davis, CA, 95618, USA. Electronic address:

Current models of language processing do not address mechanisms at the neurotransmitter level, nor how pharmacologic agents may improve language function(s) in seemingly disparate disorders. L-Glutamate, the primary excitatory neurotransmitter in the human brain, is extensively involved in various higher cortical functions. We postulate that the physiologic role of L-Glutamate neurotransmission extends to the regulation of language access, comprehension, and production, and that disorders in glutamatergic transmission and circuitry contribute to the pathogenesis of neurodegenerative diseases and sporadic-onset language disorders such as the aphasic stroke syndromes. We start with a review of basic science data pertaining to various glutamate receptors in the CNS and ways that they may influence the physiological processes of language access and comprehension. We then focus on the dysregulation of glutamate neurotransmission in three conditions in which language dysfunction is prominent: Alzheimer's Disease, Fragile X-associated Tremor/Ataxia Syndrome, and Aphasic Stroke Syndromes. Finally, we review the pharmacologic and electrophysiologic (event related brain potential or ERP) data pertaining to the role glutamate neurotransmission plays in language processing and disorders.
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http://dx.doi.org/10.1016/j.neubiorev.2020.09.023DOI Listing
December 2020

Design and evaluation of a modularized ankle-foot orthosis with quick release mechanism.

Annu Int Conf IEEE Eng Med Biol Soc 2020 07;2020:4831-4834

Ankle foot orthosis (AFO) stiffness affects ankle range of motion but can also provide energy storage and return to improve mobility. To perform multiple activities during the day, a person may want to change their AFO stiffness to meet their activity's demand. Carrying multiple AFOs and changing AFOs is inconvenient and could discourage users from engaging in multiple activities. This project will develop a new quick-release mechanism (QRM) that allows users to easily change posterior strut elements to change AFO stiffness. The QRM attaches to the AFO and requires no tools to operate. The proposed QRM includes a quick-release key, weight-bearing pin, receptacle anchor, and immobilization pin. A prototype was modelled with SolidWorks and simulated with SolidWorks Simulation. The QRM was designed to have no mechanical failure during intense activities such as downhill walking and jogging. Unlike a solid screw connection, the QRM needed an additional part to eliminate unsecured motion related to clearance between the quick release key and receptacle anchor. Mechanical test results and measurement data proved no deformation on each part after mechanical testing.Clinical Relevance- The quick release AFO has the potential to improve user's activities range by tuning from stiffness free mode to high stiffness mode.
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http://dx.doi.org/10.1109/EMBC44109.2020.9175829DOI Listing
July 2020

Coronavirus hemagglutinin-esterase and spike proteins coevolve for functional balance and optimal virion avidity.

Proc Natl Acad Sci U S A 2020 10 29;117(41):25759-25770. Epub 2020 Sep 29.

Virology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, The Netherlands;

Human coronaviruses OC43 and HKU1 are respiratory pathogens of zoonotic origin that have gained worldwide distribution. OC43 apparently emerged from a bovine coronavirus (BCoV) spillover. All three viruses attach to 9--acetylated sialoglycans via spike protein S with hemagglutinin-esterase (HE) acting as a receptor-destroying enzyme. In BCoV, an HE lectin domain promotes esterase activity toward clustered substrates. OC43 and HKU1, however, lost HE lectin function as an adaptation to humans. Replaying OC43 evolution, we knocked out BCoV HE lectin function and performed forced evolution-population dynamics analysis. Loss of HE receptor binding selected for second-site mutations in S, decreasing S binding affinity by orders of magnitude. Irreversible HE mutations led to cooperativity in virus swarms with low-affinity S minority variants sustaining propagation of high-affinity majority phenotypes. Salvageable HE mutations induced successive second-site substitutions in both S and HE. Apparently, S and HE are functionally interdependent and coevolve to optimize the balance between attachment and release. This mechanism of glycan-based receptor usage, entailing a concerted, fine-tuned activity of two envelope protein species, is unique among CoVs, but reminiscent of that of influenza A viruses. Apparently, general principles fundamental to virion-sialoglycan interactions prompted convergent evolution of two important groups of human and animal pathogens.
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http://dx.doi.org/10.1073/pnas.2006299117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568303PMC
October 2020

Letter of response (2) - Data integrity of 35 randomised controlled trials in women' health.

Eur J Obstet Gynecol Reprod Biol 2020 12 30;255:261-262. Epub 2020 Aug 30.

Department of Obstetrics and Gynecology, Monash University, Clayton, Australia.

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http://dx.doi.org/10.1016/j.ejogrb.2020.08.050DOI Listing
December 2020

To share or not to share data: how valid are trials evaluating first-line ovulation induction for polycystic ovary syndrome?

Hum Reprod Update 2020 Nov;26(6):929-941

Department of Obstetrics and Gynecology, Monash University, Clayton, Australia.

Background: In our recent individual participant data (IPD) meta-analysis evaluating the effectiveness of first-line ovulation induction for polycystic ovary syndrome (PCOS), IPD were only available from 20 studies of 53 randomized controlled trials (RCTs). We noticed that the summary effect sizes of meta-analyses of RCTs without IPD sharing were different from those of RCTs with IPD sharing. Granting access to IPD for secondary analysis has implications for promoting fair and transparent conduct of RCTs. It is, however, still common for authors to choose to withhold IPD, limiting the impact of and confidence in the results of RCTs and systematic reviews based on aggregate data.

Objective And Rationale: We performed a meta-epidemiologic study to elucidate if RCTs without IPD sharing have lower quality and more methodological issues than those with IPD sharing in an IPD meta-analysis evaluating first-line ovulation induction for PCOS.

Search Methods: We included RCTs identified for the IPD meta-analysis. We dichotomized RCTs according to whether they provided IPD (shared group) or not (non-shared group) in the IPD meta-analysis. We restricted RCTs to full-text published trials written in English.We assessed and compared RCTs in the shared and non-shared groups on the following criteria: Risk of Bias (RoB 2.0), GRADE approach, adequacy of trial registration; description of statistical methods and reproducibility of univariable statistical analysis; excessive similarity or difference in baseline characteristics that is not compatible with chance; and other miscellaneous methodological issues.

Outcomes: In total, 45 trials (8697 women) were included in this study. IPD were available from 17 RCTs and 28 trials were categorized as the non-shared IPD group. Pooled risk rates obtained from the shared and non-shared groups were different. Overall low risk of bias was associated with 13/17 (76%) of shared RCTs versus 7/28 (25%) of non-shared RCTs. For RCTs that started recruitment after 1 July 2005, adequate trial registration was found in 3/9 (33%) of shared IPD RCTs versus 0/16 (0%) in non-shared RCTs. In total, 7/17 (41%) of shared RCTs and 19/28 (68%) of non-shared RCTs had issues with the statistical methods described. The median (range) of inconsistency rate per study, between reported and reproduced analyses for baseline variables, was 0% (0-92%) (6 RCTs applicable) in the shared group and 54% (0-100%) (13 RCTs applicable) in the non-shared group. The median (range) of inconsistency rate of univariable statistical results for the outcome(s) per study was 0% (0-63%) (14 RCTs applicable) in the shared group and 44% (0-100%) (24 RCTs applicable) in the non-shared group. The distributions of simulation-generated P-values from comparisons of baseline continuous variables between intervention and control arms suggested that RCTs in the shared group are likely to be consistent with properly conducted randomization (P = 0.163), whereas this was not the case for the RCTs in the non-shared group (P = 4.535 × 10-8).

Wider Implications: IPD meta-analysis on evaluating first-line ovulation induction for PCOS preserves validity and generates more accurate estimates of risk than meta-analyses using aggregate data, which enables more transparent assessments of benefits and risks. The availability of IPD and the willingness to share these data may be a good indicator of quality, methodological soundness and integrity of RCTs when they are being considered for inclusion in systematic reviews and meta-analyses.
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http://dx.doi.org/10.1093/humupd/dmaa031DOI Listing
November 2020

Quasi-metal Microwave Route to MoN and MoC Ultrafine Nanocrystalline Hollow Spheres as Surface-Enhanced Raman Scattering Substrates.

ACS Nano 2020 Oct 21;14(10):13718-13726. Epub 2020 Sep 21.

Institute of Industrial and Consumer Product Safety, Chinese Academy of Inspection and Quarantine, No. 11, Ronghua South Road, Beijing 100176, P.R. China.

MoN and MoC are important functional materials; however, due to the high activation energy barrier in their nucleation, their synthesis generally requires harsh conditions such as high temperature (>1000 °C) and high pressure (several GPa). The extreme conditions also hinder the acquisition of their ultrafine nanostructures. Herein, we report that MoN and MoC hollow spheres with large surface area (108.7-125.6 m g) and ultrafine nanoparticles (2-5 nm) are prepared by a quasi-metal-based microwave route under mild conditions. MoO hollow spheres are used as a quasi-metallic microwave absorbing medium as well as a molybdenum source and template simultaneously. The MoN and MoC ultrafine nanocrystalline hollow spheres exhibit strong localized surface plasmon resonance, high photothermal conversion efficiency, and strong surface-enhanced Raman scattering effects. Highly crystalline MoS nanosheet hollow spheres can also be obtained by this method, indicating its universality. The present work provides an effective strategy for the rapid and mild preparation of ultrafine nanocrystalline transition metal nitrides and carbides with ultrahigh activation energy.
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http://dx.doi.org/10.1021/acsnano.0c05935DOI Listing
October 2020

Integrin αVβ5/Akt/Sp1 pathway participates in matrix stiffness-mediated effects on VEGFR2 upregulation in vascular endothelial cells.

Am J Cancer Res 2020 1;10(8):2635-2648. Epub 2020 Aug 1.

Department of Interventional Radiology, Fudan University Shanghai Cancer Center Shanghai 200032, People's Republic of China.

Our previous study has validated that higher matrix stiffness obviously improves vascular endothelial growth factor (VEGF) expression in HCC cells, highlighting a linkage between matrix stiffness and HCC angiogenesis. However, the effects of matrix stiffness on vascular endothelial cells in HCC and its underlying mechanism remain largely uncharacterized. Here we further analyzed the expression of vascular endothelial growth factor receptor 2 (VEGFR2) in human umbilical vein endothelial cells (HUVECs) grown on different stiffness substrates and explored its regulatory mechanism for better understanding matrix stiffness-regulated angiogenesis in HCC. Our results revealed that increased matrix stiffness significantly upregulated the expression of VEGFR2 in HUVECs, and the expression level of VEGFR2 was positively correlated with the expression levels of COL1 and lysyl oxidase in human HCC tissues and rat HCC tissue, moreover VEGFR2 and CD34 were co-localized at blood vessel of HCC tissues, indicating an obvious regulation role of matrix stiffness in VEGFR2 expression. Simultaneously, increased matrix stiffness also elevated the phosphorylation level of Akt and the expressions of integrin αV/β5 and nuclear Sp1 in HUVECs. Inhibition of integrin αVβ5 remarkably reversed the expression of VEGFR2 and phosphorylation level of Akt in HUVECs grown on higher stiffness substrate. Except that, PI3K inhibitor also suppressed the phosphorylation level of Akt and the expressions of VEGFR2 and nuclear Sp1 evidently. Taken together, higher matrix stiffness increased VEGFR2 expression in HUVECs, and integrin αVβ5/Akt/Sp1 pathway participated in stiffness-mediated effects on VEGFR2 upregulation. This study combining with our previous report discloses a new paradigm in which higher matrix stiffness as an initiator drives HCC angiogenesis via upregulating both VEGFR2 expression in vascular endothelial cells and VEGF expression in HCC cells.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471346PMC
August 2020

The clinical value of the changes of peripheral lymphocyte subsets absolute counts in patients with non-small cell lung cancer.

Transl Oncol 2020 Dec 28;13(12):100849. Epub 2020 Aug 28.

First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Clinic Laboratory, Tianjin, China.

Introduction: Immune function strongly influences the outcome of patients with non-small cell lung cancer (NSCLC). It's vital to understand the immune state of patients through detecting the percentage and number of lymphocyte subsets accurately, and helpful to evaluate conditions of prognosis and adjust treatment for patients.

Methods: We conducted a retrospective cohort study in First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China. The absolute counts and percentages of CD3+, CD3 + CD4+, CD3 + CD8+, B and NK cells were determined by single platform technologies. 172 patients received treatment including surgery or chemotherapy after surgery. The factors affecting disease progression were analyzed by Binary Logistic regression. Progression free survival (PFS) calculating survivals were with the method of Kaplan-Meier. The log-rank test and cox's proportional hazard regression (enter method) were used for univariable and multivariable analyses respectively.

Results: Relative to normal controls, patients with NSCLC at different stages showed decreased absolute lymphocyte count obviously, rather than lymphocyte percentages. Different treatments had unlike influence on the homeostasis of lymphocytes and the effects last for a long time. Logistic regression showed CD3 + CD4+ and CD3 + CD8+ could contribute to favorable prognosis. Multivariate analysis of prognostic factors of PFS showed CD3 + CD4+ cell was independent factor for predicting PFS.

Conclusions: The absolute count of CD3+, CD3 + CD4+, CD3 + CD8+, B and NK cells were better indication of the patient's immune state than percentages of each lymphocyte subsets. Immune function was impaired in patients with non-small cell lung. The high level of baseline absolute CD3 + CD4+ cells count contributed to longer progression free survival. Chinese Clinic Trial Registry number: ChiCTR-IOR-17014139; Registry date: 2017/12/25.
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http://dx.doi.org/10.1016/j.tranon.2020.100849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7475266PMC
December 2020

Accurate serology for SARS-CoV-2 and common human coronaviruses using a multiplex approach.

Emerg Microbes Infect 2020 Dec;9(1):1965-1973

Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.

Serology is a crucial part of the public health response to the ongoing SARS-CoV-2 pandemic. Here, we describe the development, validation and clinical evaluation of a protein micro-array as a quantitative multiplex immunoassay that can identify S and N-directed SARS-CoV-2 IgG antibodies with high specificity and sensitivity and distinguish them from all currently circulating human coronaviruses. The method specificity was 100% for SARS-CoV-2 S1 and 96% for N antigen based on extensive syndromic (n=230 cases) and population panel (n=94) testing that also confirmed the high prevalence of seasonal human coronaviruses. To assess its potential role for both SARS-CoV-2 patient diagnostics and population studies, we evaluated a large heterogeneous COVID-19 cohort (n=330) and found an overall sensitivity of 89% (≥ 21 days post onset symptoms (dps)), ranging from 86% to 96% depending on severity of disease. For a subset of these patients longitudinal samples were provided up to 56 dps. Mild cases showed absent or delayed, and lower SARS-CoV-2 antibody responses. Overall, we present the development and extensive clinical validation of a multiplex coronavirus serological assay for syndromic testing, to answer research questions regarding to antibody responses, to support SARS-CoV-2 diagnostics and to evaluate epidemiological developments efficiently and with high-throughput.
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http://dx.doi.org/10.1080/22221751.2020.1813636DOI Listing
December 2020

Contralateral Dependent Position During Percutaneous CT-Guided Core Needle Biopsy for Small (≤ 20 mm) Lung Lesions Adjacent to the Pericardium: Effect on Procedures and Complications.

Cardiovasc Intervent Radiol 2020 Nov 16;43(11):1652-1660. Epub 2020 Aug 16.

Deparment of Interventional Radiology, Fudan University Shanghai Cancer Center, No. 270 Dongan Road, Xuhui, Shanghai, 200032, China.

Purpose: To assess the effect of contralateral dependent position on procedures and complications of percutaneous computed tomography (CT)-guided core needle biopsy (PCT-CNB) for small (≤ 20 mm) lung lesions adjacent to the pericardium.

Materials And Methods: Retrospective view was performed to identify patients with small (≤ 20 mm) lung lesions located within 10 mm of the pericardium and who underwent PCT-CNB in the standard supine or prone position (n = 66) or in contralateral dependent position ( n = 35) between March 2010 and January 2020. In 35 patients, CT images in the contralateral dependent position were compared with images in the supine position to assess the mean distance of the lesion from the pericardium and the mean length of interface between these two positions. Complications including rates of pneumothorax, chest tube insertion, and pulmonary hemorrhage were assessed.

Results: In comparison with axial images in supine position, the pericardium were located farther from the lesion in the contralateral dependent position; the mean distance of lesions from the pericardium became farther (P < 0.001), and the mean length of interface with the pericardium became shorter (P = 0.008). There was no difference in the complication rates between supine or prone position and contralateral dependent position (pneumothorax, P = 0.098; pulmonary hemorrhage, P = 0.791).

Conclusion: Placing patients in contralateral dependent position may confer some advantages, including maximizing distance and minimizing length of interface of the lesion to the pericardium during PCT-CNB for small (≤ 20 mm) lung lesions adjacent to the pericardium.
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http://dx.doi.org/10.1007/s00270-020-02608-0DOI Listing
November 2020