Publications by authors named "Wenli Cheng"

18 Publications

  • Page 1 of 1

Survey on sodium and potassium intake in patients with hypertension in China.

J Clin Hypertens (Greenwich) 2021 Sep 25. Epub 2021 Sep 25.

Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Sodium and potassium intake in hypertensive patients in China is not clear. The authors aimed to investigate the distribution of sodium and potassium intake in hypertensive patients in China, and to analyze the relationship between sodium and potassium intake and blood pressure. The study was performed in 130 hospitals from 23 provinces across China from 2016 to 2019. Finally, 9501 hypertensive patients average aged 54 years were included. 24 h urinary sodium and potassium excretion were measured. Distribution of urinary electrolytes were described according to age, gender and region. The association between urinary electrolytes and blood pressure was analyzed by multivariate linear regression. Hypertensive patients exhibited an average 24 h urinary sodium and potassium excretion of 156.7 ± 81.5 mmol/d and 39.2 ± 20.2 mmol/d (equivalent to sodium chloride of 9.2 g/d, potassium chloride of 2.9 g/d), sodium/potassium ratio (median) of 4.14 (2.92,5.73). Urinary electrolytes were lower in women than men (sodium: 171.1 vs 138.7, p < .05; potassium: 40.3 vs 37.7, p < .05), in the elderly than in the younger (sodium: 168.7 vs 139.9, p < .05; potassium: 39.5 vs. 37.5, p < .05). For every 1 unit of Na/K ratio increase, blood pressure increased by 0.46/0.24 mmHg. Blood pressure was 2.75/1.27 mmHg higher in quartile 4 than quartile 1 of Na/K. It remains high sodium and low potassium for hypertensive patients in China. Decreased sodium, Na/K ratio and increased potassium may help for blood pressure management.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/jch.14355DOI Listing
September 2021

Early marriage and maternal health care utilisation: Evidence from sub-Saharan Africa.

Econ Hum Biol 2021 Aug 19;43:101054. Epub 2021 Aug 19.

Victoria Institute of Strategic Economic Studies, Victoria University, Melbourne, Australia.

We use the recursive bivariate probit (RBVP) model to estimate the effects of early marriage on the utilisation of maternal health services in five sub-Saharan countries: Burkina Faso, Guinea, Mali, Niger and Chad. Based on recent Demographic and Health Surveys (DHS), we find that a woman who married before age 15 was 17 percentage points less likely to use prenatal services; and marrying before age 16 reduced that likelihood by 9.6 percentage points. We have not found any statistically significant reduction in maternal health care utilisation for women who married at age 17 or older.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ehb.2021.101054DOI Listing
August 2021

Efficacy of ARB/HCTZ Combination Therapy in Uncontrolled Hypertensive Patients Compared with ARB Monotherapy: A Meta-Analysis.

Int J Hypertens 2021 27;2021:6670183. Epub 2021 Apr 27.

Department of Hypertension, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Objective: To evaluate the efficacy of combination of angiotensin receptor blocker (ARB) with hydrochlorothiazide (HCTZ) compared to ARB alone in patients with uncontrolled hypertension via a systematic review and meta-analysis.

Methods: We searched databases till July 2019 using relevant search terms. We included articles that were randomised controlled trials (RCTs) comparing ARB/HCTZ with ARB for a duration of at least 4 weeks and reported on the efficacy or safety. Meta-analyses for efficacy outcomes were performed. In addition, groups given different concentrations of HCTZ (12.5 and 25 mg) were analysed separately.

Results: Sixteen RCTs (12,055 participants) were included. Overall, ARB/HCTZ combination therapy (both 12.5 and 25 mg HCTZ combination) resulted in better sitting systolic and diastolic blood pressure control than ARB alone (mean difference (95% confidence interval (CI): -5.69 [-6.66, -4.73] for 12.5 mg and -9.10 [-11.78, -6.42] for 25 mg and mean difference (95% CI): -2.91 [-3.31, -2.51] for 12.5 mg and -4.16 [-4.75, -3.58] for 25 mg). ARB/HCTZ combination therapy resulted in a higher rate of target blood pressure achievement compared to ARB alone (risk ratio (95% CI): 1.50 [1.42, 1.59]). ARB/HCTZ combination therapy had similar rates of total adverse events (AEs) and severe AEs compared to ARB alone.

Conclusion: ARB/HCTZ combination therapy is more efficacious for controlling blood pressure, and combination with a low concentration of HCTZ has similar AEs compared to ARB alone. Clinicians should consider adding HCTZ in the medication regime of patients with uncontrolled hypertension using ARB, if their clinical profile allows.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1155/2021/6670183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8096582PMC
April 2021

Contribution of microalgae to carbon sequestration in a natural karst wetland aquatic ecosystem: An in-situ mesocosm study.

Sci Total Environ 2021 May 25;768:144387. Epub 2020 Dec 25.

Institute of Resource Biology and Biotechnology, Department of Biotechnology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China; Key Laboratory of Molecular Biophysics, Ministry of Education, Wuhan 430074, China.

Carbonate rock weathering coupled with aquatic photosynthesis in karst areas is an important part in the formation of terrestrial carbon sinks. The capacity of photosynthetic carbon sequestration by aquatic microalgae and carbonic anhydrase (CA) is integral in the estimation of carbon sink potential of karst aquatic ecosystems. To date, carbon sequestration by aquatic microalgae in karst areas has been investigated in laboratory experiments. In the present work, the capacity of carbon sequestration by microalgae and CA under natural karst aquatic conditions and the main environmental factors were investigated in field in-situ mesocosms. The Sizhitan Pond of the Huixian karst wetland in Guilin City, Guangxi Province, China, was selected as a typical karst natural water body for this study. The capacity of photosynthetic carbon sequestration varied with microalgal community composition. The microalgal communities with active extracellular CA showed high capacity of carbon sequestration. The average conversion of inorganic carbon to relatively stable organic carbon by microalgae in the Huixian karst wetland aquatic ecosystem was estimated as 4207.5 t C/a. Approximately 28.7% of the bicarbonate fed by the karst underground river was fixed into organic carbon by microalgal photosynthesis. The major environmental factors affecting the capacity of carbon sequestration by microalgae in the karst wetland aquatic ecosystem were the water CA activity, illumination, temperature, total phosphorus and total nitrogen. This study is the first to address the contribution of aquatic microalgae and CA to carbon sequestration under natural karst aquatic conditions. The findings contribute to establishing groundwork for substantiating the carbon sink potential in global karst ecosystems.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2020.144387DOI Listing
May 2021

C1q/TNF-related protein-9 is elevated in hypertension and associated with the occurrence of hypertension-related atherogenesis.

Cell Biol Int 2021 May 15;45(5):989-1000. Epub 2021 Jan 15.

Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

C1q-tumor necrosis factor-related protein-9 (CTRP9) is an important adipocytokine that is closely associated with cardiovascular disease. This study aimed to detect CTRP9 expression in hypertensive patients and mice and to analyze its effects on hypertension-related atherogenesis. First, circulating CTRP9 levels were detected in both nonhypertensive subjects and hypertensive patients. The results showed that plasma CTRP9 levels were increased in hypertension patients compared with control subjects and gradually elevated in the Grade I, Grade II, and Grade III groups. While nondipper state did not affect CTRP9 expression in hypertension patients. Hypertension patients with carotid atherosclerotic plaque (CAP) exhibited higher CTRP9 levels and the high CTRP9 group exhibited significantly higher CAP morbidity, CTRP9 levels were positively correlated with the occurrence of CAP. Then, effects of CTRP9 on angiotensin II (Ang II)-induced endothelial dysfunction were analyzed in vitro, and the results exhibited that treatment with Ang II significantly increased CTRP9 mRNA expression in endothelial cells (ECs), and downregulation of CTRP9 expression aggravated Ang II-induced endothelial dysfunction in ECs. Mice were infused with Ang II, and CTRP9 was also increased in Ang II-infused mice and mainly secreted by ECs. In Ang II-infused ApoE mice, treatment with recombinant CTRP9 significantly reduced atherosclerotic area and alleviated endothelial dysfunction. In conclusion, our results may found that CTRP9 delayed the progression of hypertension-related arteriosclerosis by alleviating endothelial dysfunction.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbin.11542DOI Listing
May 2021

Efficacy of metformin in preventing progression to diabetes in a Chinese population with impaired glucose regulation: Protocol for a multicentre, open-label, randomized controlled clinical study.

Diabetes Obes Metab 2020 02 24;22(2):158-166. Epub 2019 Oct 24.

Department of Endocrinology, Fuwai Hospital & Chinese Academy of Medical Sciences, Beijing, China.

Aim: To investigate the effectiveness of metformin in delaying or preventing progression to diabetes in a Chinese population with impaired glucose regulation (IGR).

Materials And Methods: This multicentre, randomized, open-label, controlled study (NCT03441750) will assess the efficacy of metformin in preventing diabetes over ≥2 years. Eligible participants will be randomly assigned (1:1) to lifestyle intervention (LSI) or metformin plus LSI, with stratification based on blood pressure, anti-hypertensive medication use and isolated/non-isolated impaired fasting glucose. All participants will receive LSI advice. Participants in the metformin plus LSI group will receive metformin 850 mg once daily for the first 2 weeks, and twice daily thereafter, according to tolerability.

Results: The primary objective is to compare rates of newly diagnosed diabetes in the two intervention groups. Changes in glycaemia, blood pressure, body weight, insulin resistance, and safety outcomes will also be evaluated.

Conclusions: This large clinical trial in a Chinese population with IGR aims to provide critical information to guide clinical decision-making in order to alleviate the current diabetes epidemic.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/dom.13884DOI Listing
February 2020

Longitudinal association between serum uric acid levels and multiterritorial atherosclerosis.

J Cell Mol Med 2019 08 26;23(8):4970-4979. Epub 2019 Jun 26.

Sanbo Brain Institute, Sanbo Brain Hospital, Capital Medical University, Beijing, China.

Multiterritorial atherosclerosis has dramatically increased annual risk of adverse cardiovascular events than atherosclerotic disease with single-artery affected. Serum uric acid (SUA) is an important predictor of stroke and atherosclerosis; however, which is supported by few direct evidence based on cohort studies. A prospective cohort study including 2644 North Chinese adults aged ≥40 years was performed in 2010-2012 to investigate the association between SUA and multiterritorial vascular stenosis. Hyperuricaemia was defined as SUA levels >6 and >7 mg/dL for males and females, respectively. All participants underwent twice transcranial Doppler (TCD) and bilateral carotid duplex ultrasound to evaluate intracranial artery stenosis (ICAS) and extracranial arterial stenosis (ECAS) and peripheral arterial disease (PAD) was determined by ankle-brachial index (ABI) on January 2010 and January 2012 based on regular health check-ups. The cumulative incidence of vascular stenosis was significantly higher in subjects with hyperuricaemia than in those without hyperuricaemia (54.1% vs. 34.7%, P < 0.001). The adjusted odds ratios (ORs) with 95% confidence intervals (CIs) for new on-set vascular stenosis due to hyperuricaemia and a 1-mg/dL change in SUA level were 1.75 (1.32-2.31) and 1.29 (1.21-1.38), respectively. Furthermore, in the gender-stratified analysis, the association between SUA levels and ICAS was statistically significant in males (OR: 2.02; 95% CI: 1.18-3.46), but not females (OR: 0.85, 95% CI: 0.41-1.76, P for interaction: 0.026).
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/jcmm.14337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6652300PMC
August 2019

Vitamin D receptor gene FokI but not TaqI, ApaI, BsmI polymorphism is associated with Hashimoto's thyroiditis: a meta-analysis.

Sci Rep 2017 01 30;7:41540. Epub 2017 Jan 30.

Department of Thyroid and Breast Surgery, West China Hospital, Sichuan University, Chendu, China.

Four VD receptor (VDR) gene polymorphisms (TaqI, ApaI, FokI and BsmI) have been reported to influence Hashimoto's thyroiditis (HT) risk. However, individual studies have produced inconsistent results. We conducted a comprehensive meta-analysis of eleven case-control studies to better understand roles of the four polymorphisms in HT development. The results showed only FokI polymorphism was significantly associated with the risk of HT (F vs f: OR = 1.44, 95% CI = 1.09-1.91, P = 0.010; FF vs Ff + ff: OR = 1.72, 95% CI = 1.09-2.70, P = 0.019). Subgroup analyses demonstrated the significant effect was only present in Asian population (F vs f: OR = 1.45, 95% CI = 1.07-1.95, P = 0.016; FF vs ff: OR = 1.64, 95% CI = 1.03-2.59, P = 0.036; FF + Ff vs ff: OR = 1.34, 95% CI = 1.00-1.80, P = 0.047; FF vs Ff + ff: OR = 1.64, 95% CI = 1.03-2.64, P = 0.039), but not in Caucasian. For TaqI, ApaI and BsmI polymorphisms, no significant association was found in any model comparison. Based on the current literature, it appears that only VDR FokI polymorphism is associated with HT risk in Asian population, but not in Caucasians; and the TaqI, ApaI and BsmI polymorphisms have not positive association neither in the overall population, nor when stratified by ethnicity. Further well-designed studies with larger sample sizes and different ethnic population are needed to clarify the present findings.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep41540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5278388PMC
January 2017

Tall cell variant of papillary thyroid carcinoma: current evidence on clinicopathologic features and molecular biology.

Oncotarget 2016 Jun;7(26):40792-40799

Department of General Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.

Tall cell variant (TCV) of papillary thyroid carcinoma (PTC) has been recognized for the past few decades as an entity showing aggressive biological behavior; however, there is considerable controversy regarding the definition, clinical and pathological features of TCV because of its rarity and difficult diagnosis. No clinical features can accurately diagnose TCV. Thus, the results of histocytology, immunohistochemistry and molecular genetics tests have important clinical implications for diagnosis. Given the aggressiveness and the increased recurrence and poor survival rates, more aggressive treatment approach and rigorous follow-up is required for patients with TCV. In the present article, we undertook a comprehensive review to summarize and discuss the various aspects of this variant, from morphology to immunohistochemistry, and molecular abnormalities from a practical and daily practice-oriented point of view.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.18632/oncotarget.8215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130045PMC
June 2016

Immunoglobulin G-Rheumatoid Factor Interferes Negatively with Serum Hepatitis B Envelope Antigen Chemiluminescent Microparticle Immunoassay.

Clin Lab 2016 ;62(6):1131-8

Background: Rheumatoid factor (RF) can interfere both positively and negatively in immunoassays. It remains unclear whether the negative interference is an exceptional phenomenon or a denominator of immunoassays and which RF subgroup plays a key role in its causation.

Methods: Serum models comprising hepatitis B envelope antigen (HBeAg) and RF were made by blending HBeAg-positive sera and RF-positive sera at a ratio of 1:9. Paramagnetic microparticles coated with P human chorionic gonadotropin (betaHCG)-anti-betaHCG complexes were used to remove RFs from the models, and HBeAg was determined in models using the chemiluminescent microparticle immunoassay (CMIA).

Results: HBeAg sample/cutoff (S/CO) relative light units (RLUs) measured in 27.06% of the serum models were significantly lower than those in the control models with a maximum decline rate of > 70.00%. The discrepancies between the HBeAg S/CO RLUs measured in serum and control models were not associated with the serum RF levels when these ranged from 20 to 1510 IU/mL. Pretreatment of the serum models with the paramagnetic microparticles increased the HBeAg S/CO RLUs measured and decreased the immunoglobulin (Ig) A-RF and IgG-RF levels significantly. However, the discrepancies between the HBeAg S/CO RLUs measured in serum models before and after pretreatment were only associated inversely with the discrepancies in IgG-RF levels.

Conclusions: Measurement of HBeAg by CMIA is susceptible to negative interference from RFs. The level of IgG-RF played a key role in interfering with HBeAg CIMA and predominantly caused falsely low results. The pretreatment of samples with blocking reagents is therefore advisable prior to the interpretation of test results.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.7754/clin.lab.2015.151110DOI Listing
September 2016

A meta-analysis of alcohol consumption and thyroid cancer risk.

Oncotarget 2016 08;7(34):55912-55923

Department of Thyroid and Breast Surgery, West China Hospital, Sichuan University, Chengdu, China.

Background: It is still inconclusive whether alcohol consumption affects the risk of thyroid cancer. We conducted a meta-analysis of available epidemiological data to address this issue.

Results: Compared with nondrinkers, the pooled relative risks (RRs) and corresponding 95% confidential intervals (CIs) of thyroid cancer were 0.80 (95% CI 0.71-0.90) for any drinkers, 0.81 (95% CI 0.70-0.93) for light and 0.71 (95% CI 0.63-0.79) for moderate drinkers. The dose-response analysis suggested that there is no evidence of a dose-risk relationship between alcohol intaking and thyroid cancer risk (P = 0.112).

Methods: Eligible studies were identified by searching PubMed and EMbase databases. A total of 24 studies, included 9,990 cases with thyroid cancer, were included in this meta-analysis. We defined light alcohol intake as ≤ one drink/day and moderate as >one drink/day. The summary risk estimates were calculated by the random effects model. A dose-response analysis was also conducted for modeling the dose-risk relation.

Conclusion: This meta-analysis confirmed an inverse association between alcohol consumption and thyroid cancer risk. Further studies are needed to better understand the potential mechanisms underlying this association.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.18632/oncotarget.10352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342461PMC
August 2016

Stabilization of G-quadruplex DNA and inhibition of Bcl-2 expression by a pyridostatin analog.

Bioorg Med Chem Lett 2016 Apr 23;26(7):1660-3. Epub 2016 Feb 23.

Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry Chinese Academy of Sciences, Beijing 100190, PR China. Electronic address:

The G-quadruplexes located in the P1 promoter of B-cell lymphoma-2 (Bcl-2) gene are implicated to regulate Bcl-2 expression. Here, we designed a new pyridostatin analog named PDF, which exhibited high specificity and stabilizing effect toward G-quadruplexes. The luciferase assay demonstrated that PDF could significantly suppress Bcl-2 transcriptional activation in human laryngeal squamous carcinoma cells (Hep-2) cells. Besides, PDF also induced cell apoptosis in vitro assays. These results provide an excellent G-quadruplex specific ligand as an efficient Bcl-2 inhibitor. These results also implicate that PDF may be a potential anticancer drug to head neck cancer.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2016.02.065DOI Listing
April 2016

The performance of age-adjusted D-dimer cut-off in Chinese outpatients with suspected venous thromboembolism.

Thromb Res 2015 Oct 26;136(4):739-43. Epub 2015 Jul 26.

Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China. Electronic address:

Background: D-dimer testing has been widely used in the exclusion of venous thromboembolism (VTE), but its clinical usefulness is limited in older patients because of a lower specificity.

Objective: To evaluate the diagnostic performance of STA-Liatest D-dimer assay and validate the age-adjusted cut-off value in Chinese outpatients with suspected VTE in a prospective non-interventional study.

Methods: Symptomatic patients suspected of having deep venous thrombosis or pulmonary embolism were recruited from 2 participating centers. STA-Liatest D-dimer assay, clinical pretest probability assessment and diagnostic imaging test including complete compression ultrasonography or computed tomography pulmonary angiography were performed among all participants. The performance of D-dimer test was assessed with an age-adjusted D-dimer cut-off (age×0.01μg/ml in patients aged>50years) and with conventional cut-off (0.5μg/ml at all ages).

Results: A total of 594 eligible outpatients were included in this study and VTE was diagnosed in 195 (32.8%) patients. In those patients with a low or moderate pretest probability (n=373), the increase in the proportion of patients with a D-dimer below the age-adjusted cut-off value compared with the conventional cut-off value was 5.9% (95% confidence interval; 3.8%-8.7%). The sensitivity, specificity and negative predictive value of STA-Liatest D-dimer test were 95.0% (83.5% - 98.6%), 84.1%(79.8%-87.6%) and 99.3%(97.5% - 99.8%), respectively, using the age-adapted diagnostic strategy.

Conclusions: The application of age-adjusted cut-off of D-dimer test combined with clinical probability greatly increases the proportion of Chinese older outpatients in whom VTE can be safely excluded.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.thromres.2015.07.024DOI Listing
October 2015

Vascular Adventitia Calcification and Its Underlying Mechanism.

PLoS One 2015 6;10(7):e0132506. Epub 2015 Jul 6.

Graduate School, Beijing University of Traditional Chinese Medicine, Beijing, China.

Previous research on vascular calcification has mainly focused on the vascular intima and media. However, we show here that vascular calcification may also occur in the adventitia. The purpose of this work is to help elucidate the pathogenic mechanisms underlying vascular calcification. The calcified lesions were examined by Von Kossa staining in ApoE-/- mice which were fed high fat diets (HFD) for 48 weeks and human subjects aged 60 years and older that had died of coronary heart disease, heart failure or acute renal failure. Explant cultured fibroblasts and smooth muscle cells (SMCs)were obtained from rat adventitia and media, respectively. After calcification induction, cells were collected for Alizarin Red S staining. Calcified lesions were observed in the aorta adventitia and coronary artery adventitia of ApoE-/-mice, as well as in the aorta adventitia of human subjects examined. Explant culture of fibroblasts, the primary cell type comprising the adventitia, was successfully induced for calcification after incubation with TGF-β1 (20 ng/ml) + mineralization media for 4 days, and the phenotype conversion vascular adventitia fibroblasts into myofibroblasts was identified. Culture of SMCs, which comprise only a small percentage of all cells in the adventitia, in calcifying medium for 14 days resulted in significant calcification.Vascular calcification can occur in the adventitia. Adventitia calcification may arise from the fibroblasts which were transformed into myofibroblasts or smooth muscle cells.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0132506PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492877PMC
April 2016

Endocrine tumours: familial nonmedullary thyroid carcinoma is a more aggressive disease: a systematic review and meta-analysis.

Eur J Endocrinol 2015 Jun 30;172(6):R253-62. Epub 2015 Jan 30.

Department of Thyroid and Breast SurgeryWest China Hospital, Sichuan University, Chendu 610041, ChinaDepartments of General SurgeryOtolaryngology-Head and Neck SurgeryAffiliated Hospital of North Sichuan Medical College, Nanchong 637000, China

Objective: There is controversy as to whether familial nonmedullary thyroid carcinoma (FNMTC) is more aggressive than sporadic NMTC (SNMTC). The aim of the study was to evaluate the biological characteristics of patients with FNMTC by a meta-analysis.

Methods: Four databases (PubMed, EMBASE, the Cochrane library databases, and the Web of Science) were searched to identify studies published before September, 2014. All original studies that compared clinical characteristics and prognosis of patients with FNMTC and SNMTC were included. The pooled effect sizes of interesting parameters were calculated by odds ratio (OR), standard mean difference (SMD), or hazard ratio (HR).

Results: Twelve studies with a total of 12 741 participants were included in this analysis. FNMTC patients had an increased rate of recurrence (OR=1.72, 95% CI: 1.34 to 2.20) and decreased disease-free survival (DFS) (HR=1.83, 95% CI: 1.34 to 2.52) in comparison with SNMTC patients. FNMTC possessed more aggressive biological behaviors, characterized by younger age at diagnosis (SMD=-0.91, 95% CI: -1.59 to -0.22), higher risk of multifocal (OR=1.50, 95% CI: 1.32 to 1.71), bilateral (OR=1.29, 95% CI: 1.00 to 1.66), extrathyroidal invasion (OR=1.20, 95% CI: 1.02 to 1.41), and lymph node metastasis (OR=1.18, 95% CI: 1.01 to 1.38).

Conclusion: FNMTC is a more aggressive disease and possesses higher recurrence rate and lower DFS. More attention and careful consideration should be paid regarding the decision about treatment for patients with FNMTC.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1530/EJE-14-0960DOI Listing
June 2015

Shengjie Tongyu Granule Inhibits Vascular Remodeling in ApoE-Gene-Knockout Mice.

Evid Based Complement Alternat Med 2012 28;2012:897875. Epub 2012 Jun 28.

Center for Cardiovascular Diseases, China-Japan Friendship Hospital, Ministry of Health, Beijing 100029, China.

The aim of the present paper was to investigate the effect of Shengjie Tongyu granule on vascular remodeling in atherosclerotic mice and the relevant underlying mechanism. Sixty male ApoE-gene-knockout mice, fed a high-fat diet from 6 weeks of age, were randomized into a Shengjie Tongyu granule group (4.00 g/kg/d), a simvastatin group (9.01 mg/kg/d), and a control group (normal saline: 0.2 mL/d). At the ages of 30 and 40 weeks, we sacrificed the mice for various measurements. The results show that treatment with Shengjie Tongyu granule and simvastatin significantly decreased lumen and plaque areas in the aortic root at 30 and 40 weeks of age, decreased grade II elastic fiber lesions in the ascending aorta at 30 weeks of age, and decreased both grade II and III lesions at 40 weeks of age, compared to controls. The content of superoxide anions, and expression of MOMA-2, plasma ICAM-1, and NFκB p50 in 30- and 40-week-old mice in the Shengjie Tongyu granule and simvastatin groups were also significantly reduced compared to the control group. In conclusion, Shengjie Tongyu granule has a clear inhibitory effect on vascular remodeling and on inflammatory pathways in ApoE-gene-knockout mice.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1155/2012/897875DOI Listing
August 2012

Fine mapping of chromosome 3q22.3 identifies two haplotype blocks in ESYT3 associated with coronary artery disease in female Han Chinese.

Atherosclerosis 2011 Oct 17;218(2):397-403. Epub 2011 Jun 17.

Department of Cardiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.

Objective: Genome-wide association study recently identified the chromosome 3q22.3 as a novel locus associated with coronary artery disease (CAD). This study was designed to identify the critical haplotype blocks within this region in Han Chinese populations.

Methods: We selected 1920 CAD patients and healthy participants from Han Chinese and genotyped 22 single nucleotide polymorphisms (SNPs) spanning 150 kilobases (kb) chromosomal region flanking rs9818870, a SNP associated with CAD at 3q22.3 in Caucasian.

Results: Seven SNPs were found to be strongly associated with CAD in females and clustered in two haplotype blocks of ESYT3 gene. This was validated in two geographically isolated case-control populations. The two blocks were 14 and 25kb long, respectively. In a combined haplotype analysis, the odds ratios (95% confidence interval, permuted P value) were 0.70 (0.58-0.83, 2×10(-5)) and 1.44 (1.20-1.72, 5×10(-5)) for haplotypes TTG and CCA in block 1 as well as 0.73 (0.61-0.87, 3×10(-4)) and 1.35 (1.13-1.62, 0.0013) for haplotypes TCG and CTT in block 2, respectively. ESYT3 was expressed in human lymphocyte, vascular endothelial cell, and smooth muscle cell. The risk factors including gender, obesity, hypertension, diabetes, and hyperlipidemia exhibited strong effects on the genetic contribution to CAD.

Conclusion: We identified two haplotype blocks of ESYT3 gene in 3q22.3 region that likely harbor functional variants, which cooperate with other risk factors and play a role in the pathogenesis of coronary artery disease in females.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.atherosclerosis.2011.06.017DOI Listing
October 2011

Synthesis of CuInS2-ZnS alloyed nanocubes with high luminescence.

Chem Commun (Camb) 2011 May 23;47(18):5217-9. Epub 2011 Mar 23.

Department of Materials Science and Engineering, National University of Singapore, Singapore, 117576.

CuInS(2)-ZnS alloyed nanocubes with high luminescence were synthesized through a solution-based diffusion method.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1039/c1cc10417aDOI Listing
May 2011
-->