Wenle Zhao

Wenle Zhao

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Wenle Zhao

Wenle Zhao

Publications by authors named "Wenle Zhao"

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41Publications

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Time-trend impact on treatment estimation in two-arm clinical trials with a binary outcome and Bayesian response adaptive randomization.

J Biopharm Stat 2019 Apr 24:1-20. Epub 2019 Apr 24.

b Department of Public Health Sciences , Medical University of South Carolina , Charleston , South Carolina , USA.

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http://dx.doi.org/10.1080/10543406.2019.1607368DOI Listing
April 2019

Imbalance control in clinical trial subject randomization-from philosophy to strategy.

J Clin Epidemiol 2018 09 5;101:116-118. Epub 2018 Mar 5.

Biometry Research Group, National Cancer Institute, 9609 Medical Center Drive, Rockville, MD 20850, USA.

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http://dx.doi.org/10.1016/j.jclinepi.2018.02.022DOI Listing
September 2018

The asymptotic maximal procedure for subject randomization in clinical trials.

Stat Methods Med Res 2018 07 16;27(7):2142-2153. Epub 2016 Nov 16.

1 Department of Public Health Sciences, Medical University of South Carolina, Charleston, USA.

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http://dx.doi.org/10.1177/0962280216677107DOI Listing
July 2018

Assessing the impact of safety monitoring on the efficacy analysis in large Phase III group sequential trials with non-trivial safety event rate.

J Biopharm Stat 2016 26;26(4):672-85. Epub 2015 May 26.

b Department of Public Health Sciences , Medical University of South Carolina , Charleston , South Carolina , USA.

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http://dx.doi.org/10.1080/10543406.2015.1052473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661138PMC
November 2017

Impact of adaptation algorithm, timing, and stopping boundaries on the performance of Bayesian response adaptive randomization in confirmative trials with a binary endpoint.

Contemp Clin Trials 2017 11 1;62:114-120. Epub 2017 Sep 1.

Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA.

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http://dx.doi.org/10.1016/j.cct.2017.08.019DOI Listing
November 2017

Guessing strategies for treatment prediction under restricted randomization with unequal allocation.

Contemp Clin Trials 2017 08 16;59:118-120. Epub 2017 May 16.

National Cancer Institute, 9609 Medical Center Drive, Rockville, MD 20850, USA.

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http://dx.doi.org/10.1016/j.cct.2017.05.009DOI Listing
August 2017

A surrogate-primary replacement algorithm for response-adaptive randomization in stroke clinical trials.

Stat Methods Med Res 2017 Jun 12;26(3):1078-1092. Epub 2015 Jan 12.

2 Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA.

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http://dx.doi.org/10.1177/0962280214567142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499496PMC
June 2017

Better alternatives to permuted block randomization for clinical trials with unequal allocation.

Hematology 2017 Jan 14;22(1):61-63. Epub 2016 Oct 14.

b Biometry Research Group , National Cancer Institute , 9609 Medical Center Drive, Rockville , MD 20850 , USA.

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http://dx.doi.org/10.1080/10245332.2016.1236996DOI Listing
January 2017

When Should ED Physicians Use an HIE? Predicting Presence of Patient Data in an HIE.

South Med J 2016 07;109(7):427-33

From the Departments of Medicine, Public Health Sciences, the Division of General Internal Medicine and Geriatrics, the South Carolina Clinical and Translational Research Institute, and the Center for Biomedical Informatics, Medical University of South Carolina, Charleston.

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http://dx.doi.org/10.14423/SMJ.0000000000000490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933325PMC
July 2016

A Comprehensive View of Frequent Emergency Department Users Based on Data from a Regional HIE.

South Med J 2016 07;109(7):434-9

From the Divisions of Emergency Medicine and General Internal Medicine and Geriatrics, the Department of Public Health Sciences, the South Carolina Clinical and Translational Research Institute, and the Center for Biomedical Informatics, Medical University of South Carolina, Charleston.

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http://dx.doi.org/10.14423/SMJ.0000000000000488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933324PMC
July 2016

A better alternative to the inferior permuted block design is not necessarily complex.

Authors:
Wenle Zhao

Stat Med 2016 May;35(10):1736-8

Department of Public Health Sciences, Medical University of South Carolina, 135 Cannon Street, Suite 305H, Charleston, SC, 29425, U.S.A.

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http://dx.doi.org/10.1002/sim.6858DOI Listing
May 2016

Architecture design of a generic centralized adjudication module integrated in a web-based clinical trial management system.

Clin Trials 2016 Apr 13;13(2):223-33. Epub 2015 Oct 13.

Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA.

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http://dx.doi.org/10.1177/1740774515611889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785064PMC
April 2016

Generalization of Wei's urn design to unequal allocations in sequential clinical trials.

Contemp Clin Trials Commun 2016 Apr;2:75-79

Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, 29425, USA.

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http://dx.doi.org/10.1016/j.conctc.2015.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747061PMC
April 2016

Minimal sufficient balance-a new strategy to balance baseline covariates and preserve randomness of treatment allocation.

Stat Methods Med Res 2015 Dec 26;24(6):989-1002. Epub 2012 Jan 26.

Division of Biostatistics and Epidemiology, Medical University of South Carolina, USA.

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http://journals.sagepub.com/doi/10.1177/0962280212436447
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http://dx.doi.org/10.1177/0962280212436447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3474894PMC
December 2015

Imaging in StrokeNet: Realizing the Potential of Big Data.

Stroke 2015 Jul 4;46(7):2000-6. Epub 2015 Jun 4.

From the Neurovascular Imaging Research Core (D.S.L.) and Department of Neurology, Comprehensive Stroke Center, Geffen School of Medicine (D.S.L., J.L.S.), University of California, Los Angeles; Departments of Neurology (G.W.A.) and Radiology (M.W.), Stanford University, Palo Alto, CA; Laboratory of Neuro Imaging, Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Los Angeles (K.C., A.W.T.); Departments of Neurology and Neurological Surgery, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO (C.P.D.); Departments of Psychiatry, Radiology, and Neuroscience (M.S.G.) and Public Health Sciences (Y.Y.P., W.Z.), Medical University of South Carolina, Charleston; Ralph H Johnson VA Medical Center, Charleston, SC (M.S.G.); University of Texas Southwestern Medical Center, Austin (S.W.); Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.); Departments of Neurology, Public Health Sciences, Human Genetics, and Neurosurgery, Miller School of Medicine, University of Miami, FL (R.L.S.); Department of Neurology, University of Cincinnati, OH (P.K., J.P.B.); Department of Neurology, University of California, Irvine (S.C.C.); and Department of Rehabilitation Medicine, Emory University School of Medicine and Center for Visual and Cognitive Neurorehabilitation, Atlanta VA Medical Center, GA (S.L.W.).

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http://stroke.ahajournals.org/lookup/doi/10.1161/STROKEAHA.1
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http://dx.doi.org/10.1161/STROKEAHA.115.009479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557967PMC
July 2015

Mass weighted urn design--A new randomization algorithm for unequal allocations.

Authors:
Wenle Zhao

Contemp Clin Trials 2015 Jul 17;43:209-16. Epub 2015 Jun 17.

Department of Public Health Sciences, Medical University of South Carolina, 135 Cannon Street, Suite 305H, Charleston, SC 29425, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cct.2015.06.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522356PMC
July 2015

Measuring continuous baseline covariate imbalances in clinical trial data.

Stat Methods Med Res 2015 Apr 24;24(2):255-72. Epub 2011 Aug 24.

Division of Biostatistics and Epidemiology, 135 Cannon Street, Suite 303, Medical University of South Carolina, Charleston, SC, USA.

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http://dx.doi.org/10.1177/0962280211416038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280338PMC
April 2015

Comparison of statistical and operational properties of subject randomization procedures for large multicenter clinical trial treating medical emergencies.

Contemp Clin Trials 2015 Mar 29;41:211-8. Epub 2015 Jan 29.

Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA.

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http://dx.doi.org/10.1016/j.cct.2015.01.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380760PMC
March 2015

A better alternative to stratified permuted block design for subject randomization in clinical trials.

Authors:
Wenle Zhao

Stat Med 2014 Dec 14;33(30):5239-48. Epub 2014 Jul 14.

Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC 29425, U.S.A.

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http://dx.doi.org/10.1002/sim.6266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262630PMC
December 2014

Managing competing demands in the implementation of response-adaptive randomization in a large multicenter phase III acute stroke trial.

Stat Med 2014 Oct 22;33(23):4043-52. Epub 2014 May 22.

Department of Public Health Science, Medical University of South Carolina, 135 Cannon Street, Charleston, SC 29425, U.S.A.

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http://dx.doi.org/10.1002/sim.6213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159417PMC
October 2014

Continuous covariate imbalance and conditional power for clinical trial interim analyses.

Contemp Clin Trials 2014 May 7;38(1):9-18. Epub 2014 Mar 7.

Medical University of South Carolina, Charleston, SC, USA.

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http://dx.doi.org/10.1016/j.cct.2014.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024327PMC
May 2014

Selection bias, allocation concealment and randomization design in clinical trials.

Authors:
Wenle Zhao

Contemp Clin Trials 2013 Sep 19;36(1):263-5. Epub 2013 Jul 19.

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http://dx.doi.org/10.1016/j.cct.2013.07.005DOI Listing
September 2013

Impact of safety monitoring on error probabilities of binary efficacy outcome analyses in large phase III group sequential trials.

Pharm Stat 2012 Jul-Aug;11(4):310-7. Epub 2012 May 16.

Division of Biostatistics and Epidemiology, Medical University of South Carolina, Charleston, SC, USA.

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http://dx.doi.org/10.1002/pst.1520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294559PMC
November 2012

Quantitative comparison of randomization designs in sequential clinical trials based on treatment balance and allocation randomness.

Pharm Stat 2012 Jan-Feb;11(1):39-48. Epub 2011 May 5.

Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.

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http://dx.doi.org/10.1002/pst.493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399213PMC
May 2012

Block urn design - a new randomization algorithm for sequential trials with two or more treatments and balanced or unbalanced allocation.

Contemp Clin Trials 2011 Nov 22;32(6):953-61. Epub 2011 Aug 22.

Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.

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http://dx.doi.org/10.1016/j.cct.2011.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206733PMC
November 2011

Quantifying the cost in power of ignoring continuous covariate imbalances in clinical trial randomization.

Contemp Clin Trials 2011 Mar 13;32(2):250-9. Epub 2010 Nov 13.

Division of Biostatistics and Epidemiology, Medical University of South Carolina, 135 Cannon Street, Suite 303, MSC 835, Charleston, SC 29425-8350, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S155171441000209
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http://dx.doi.org/10.1016/j.cct.2010.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288592PMC
March 2011

A simplified formula for quantification of the probability of deterministic assignments in permuted block randomization.

J Stat Plan Inference 2011 Jan;141(1):474-478

Department of Medicine, Medical University of South Carolina, Charleston, SC, USA.

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http://dx.doi.org/10.1016/j.jspi.2010.06.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2968741PMC
January 2011

Step-forward randomization in multicenter emergency treatment clinical trials.

Acad Emerg Med 2010 Jun;17(6):659-65

Department of Medicine, Medical University of South Carolina, Charleston, SC, USA.

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http://dx.doi.org/10.1111/j.1553-2712.2010.00746.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3052925PMC
June 2010

A web-based clinical trial management system for a sham-controlled multicenter clinical trial in depression.

Clin Trials 2010 Apr 18;7(2):174-82. Epub 2010 Jan 18.

Department of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, Charleston, SC, USA.

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http://dx.doi.org/10.1177/1740774509358748DOI Listing
April 2010

An electronic regulatory document management system for a clinical trial network.

Contemp Clin Trials 2010 Jan 24;31(1):27-33. Epub 2009 Sep 24.

Department of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, Charleston, SC, USA.

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http://dx.doi.org/10.1016/j.cct.2009.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829838PMC
January 2010

Text-mining approach to evaluate terms for ontology development.

J Biomed Inform 2009 Oct 24;42(5):824-30. Epub 2009 Mar 24.

Bioinformatics Graduate Program, Department of Biostatistics, Bioinformatics & Epidemiology, Medical University of South Carolina, 135 Cannon Street, Suite 303, Charleston, SC 29424, USA.

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http://dx.doi.org/10.1016/j.jbi.2009.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153945PMC
October 2009

Two pharmacy interventions to improve refill persistence for chronic disease medications: a randomized, controlled trial.

Med Care 2009 Jan;47(1):32-40

Department of Biostatistics, Bioinformatics, and Epidemiology, Medical University of South Carolina, Charleston, SC 29425, USA.

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http://dx.doi.org/10.1097/MLR.0b013e3181808c17DOI Listing
January 2009

Prevalence, treatment, and control of hypertension among African Americans and Caucasians at primary care sites for medically under-served patients.

Ethn Dis 2005 ;15(1):25-32

Summer Undergraduate Research Training Program, College of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

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May 2005