Wenjie Tan

Wenjie Tan

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Wenjie Tan

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Structural definition of a neutralization epitope on the N-terminal domain of MERS-CoV spike glycoprotein.

Nat Commun 2019 Jul 11;10(1):3068. Epub 2019 Jul 11.

The Ministry of Education Key Laboratory of Protein Science, Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, Collaborative Innovation Center for Biotherapy, School of Life Sciences, Tsinghua University, 100084, Beijing, China.

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http://dx.doi.org/10.1038/s41467-019-10897-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624210PMC
July 2019

High-Throughput Screening and Identification of Potent Broad-Spectrum Inhibitors of Coronaviruses.

J Virol 2019 Jun 29;93(12). Epub 2019 May 29.

NHC Key Laboratory of Biosafety, Ministry of Health, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China

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http://dx.doi.org/10.1128/JVI.00023-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613765PMC
June 2019

Improving Cross-Protection against Influenza Virus Using Recombinant Vaccinia Vaccine Expressing NP and M2 Ectodomain Tandem Repeats.

Virol Sin 2019 Jun 25. Epub 2019 Jun 25.

NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.

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http://dx.doi.org/10.1007/s12250-019-00138-9DOI Listing
June 2019

Development and optimized pairing of mouse monoclonal antibodies for detecting hemagglutinin in novel H7 subtype influenza viruses.

Sci China Life Sci 2019 May 28. Epub 2019 May 28.

NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control & Prevention, Chinese Center for Disease Control and Prevention, China CDC, Beijing, 102206, China.

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http://dx.doi.org/10.1007/s11427-018-9486-0DOI Listing
May 2019

Humoral and cellular immunity against both ZIKV and poxvirus is elicited by a two-dose regimen using DNA and non-replicating vaccinia virus-based vaccine candidates.

Vaccine 2019 Apr 6;37(15):2122-2130. Epub 2019 Mar 6.

Key Laboratory of Laboratory Medicine, Ministry of Education, and Zhejiang Provincial Key Laboratory of Medical Genetics, Institute of Medical Virology, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Zhejiang, China; National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2019.02.063DOI Listing
April 2019

A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike.

Sci Adv 2019 Apr 10;5(4):eaav4580. Epub 2019 Apr 10.

Shanghai Public Health Clinical Center and School of Basic Medical Sciences, and Key Laboratory of Medical Molecular Virology of MOE/MOH, Fudan University, Shanghai 200032, China.

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http://advances.sciencemag.org/lookup/doi/10.1126/sciadv.aav
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http://dx.doi.org/10.1126/sciadv.aav4580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457931PMC
April 2019

HBV antigen and DNA loss from mouse serum is associated with novel vaccine-induced HBV surface antigen-specific cell-mediated immunity and cytokine production.

Antiviral Res 2019 Jan 10;161:20-27. Epub 2018 Nov 10.

MOH Key Laboratory of Medical Virology, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.antiviral.2018.11.002DOI Listing
January 2019

A novel human mAb (MERS-GD27) provides prophylactic and postexposure efficacy in MERS-CoV susceptible mice.

Sci China Life Sci 2018 Oct 7;61(10):1280-1282. Epub 2018 Aug 7.

National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.

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http://dx.doi.org/10.1007/s11427-018-9343-8DOI Listing
October 2018

Significant Spike-Specific IgG and Neutralizing Antibodies in Mice Induced by a Novel Chimeric Virus-Like Particle Vaccine Candidate for Middle East Respiratory Syndrome Coronavirus.

Virol Sin 2018 Oct 29;33(5):453-455. Epub 2018 Oct 29.

MOH Key Laboratory of Medical Virology, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.

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http://dx.doi.org/10.1007/s12250-018-0064-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235757PMC
October 2018

Ultrapotent Human Neutralizing Antibody Repertoires Against Middle East Respiratory Syndrome Coronavirus From a Recovered Patient.

J Infect Dis 2018 Sep;218(8):1249-1260

MOH Key Laboratory of Medical Virology, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.

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http://dx.doi.org/10.1093/infdis/jiy311DOI Listing
September 2018

Genotypic Diversity and Epidemiology of Human Rhinovirus Among Children With Severe Acute Respiratory Tract Infection in Shanghai, 2013-2015.

Front Microbiol 2018 7;9:1836. Epub 2018 Aug 7.

Key Laboratory of Laboratory Medicine, Ministry of Education, Institute of Medical Virology, Wenzhou Medical University, Wenzhou, China.

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http://dx.doi.org/10.3389/fmicb.2018.01836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090050PMC
August 2018

Predicting the receptor-binding domain usage of the coronavirus based on kmer frequency on spike protein.

Infect Genet Evol 2018 07 4;61:183-184. Epub 2018 Apr 4.

College of Biology, Hunan University, Changsha, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15671348183012
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http://dx.doi.org/10.1016/j.meegid.2018.03.028DOI Listing
July 2018

The immune response of rhesus macaques to novel vaccines comprising hepatitis B virus S, PreS1, and Core antigens.

Vaccine 2018 06 16;36(26):3740-3746. Epub 2018 May 16.

MOH Key Laboratory of Medical Virology, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2018.05.061DOI Listing
June 2018

Enhanced protection in mice induced by immunization with inactivated whole viruses compare to spike protein of middle east respiratory syndrome coronavirus.

Emerg Microbes Infect 2018 Apr 4;7(1):60. Epub 2018 Apr 4.

MOH Key Laboratory of Medical Virology, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.

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http://dx.doi.org/10.1038/s41426-018-0056-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884803PMC
April 2018

The persistent prevalence and evolution of cross-family recombinant coronavirus GCCDC1 among a bat population: a two-year follow-up.

Sci China Life Sci 2017 12 1;60(12):1357-1363. Epub 2017 Dec 1.

CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.

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http://dx.doi.org/10.1007/s11427-017-9263-6DOI Listing
December 2017

Dr. Chi-Ming Chu: Respected founder of molecular virology and pioneer of biologicals in China.

Protein Cell 2017 09;8(9):629-633

Biotech Center for Viral Diseases Emergency, Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, 102206, China.

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http://dx.doi.org/10.1007/s13238-017-0445-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563287PMC
September 2017

AMgBi (A = Ca, Sr, Eu): Magnesium Bismuth Based Zintl Phases as Potential Thermoelectric Materials.

Inorg Chem 2017 Sep 22;56(17):10576-10583. Epub 2017 Aug 22.

State Key Laboratory of Crystal Materials, Institute of Crystal Materials, Shandong University , Jinan, ShanDong 250100, People's Republic of China.

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http://dx.doi.org/10.1021/acs.inorgchem.7b01548DOI Listing
September 2017

Recombinant vaccinia vector-based vaccine (Tiantan) boosting a novel HBV subunit vaccine induced more robust and lasting immunity in rhesus macaques.

Vaccine 2017 06 6;35(25):3347-3353. Epub 2017 May 6.

Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2017.04.059DOI Listing
June 2017

Discovery of a novel canine respiratory coronavirus support genetic recombination among betacoronavirus1.

Virus Res 2017 06 13;237:7-13. Epub 2017 May 13.

Institute of Medical Virology, Wenzhou Medical University, Wenzhou 325000, China; Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, China CDC, Beijing 102206, China. Electronic address:

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http://dx.doi.org/10.1016/j.virusres.2017.05.006DOI Listing
June 2017

A screen for inhibitory peptides of hepatitis C virus identifies a novel entry inhibitor targeting E1 and E2.

Sci Rep 2017 06 21;7(1):3976. Epub 2017 Jun 21.

Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, 102206, China.

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http://dx.doi.org/10.1038/s41598-017-04274-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479846PMC
June 2017

A novel neutralizing monoclonal antibody targeting the N-terminal domain of the MERS-CoV spike protein.

Emerg Microbes Infect 2017 Jun 28;6(6):e60. Epub 2017 Jun 28.

School of Laboratory Medicine and Life Science, Institute of Medical Virology, Wenzhou Medical University, Wenzhou 325035, China.

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http://dx.doi.org/10.1038/emi.2017.50DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520321PMC
June 2017

A novel neutralizing monoclonal antibody targeting the N-terminal domain of the MERS-CoV spike protein.

Emerg Microbes Infect 2017 May 24;6(5):e37. Epub 2017 May 24.

School of Laboratory Medicine and Life Science and Key Laboratory of Medical Virology, Wenzhou 325035, China.

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http://dx.doi.org/10.1038/emi.2017.18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520482PMC
May 2017

A47 Origin and possible genetic recombination of the middle east respiratory syndrome coronavirus from the first imported case in china: phylogenetics and coalescence analysis.

Virus Evol 2017 Mar 5;3(Suppl 1). Epub 2017 Mar 5.

Key Laboratory of Medical Virology Ministry of Health, National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention, Beijing, China.

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http://dx.doi.org/10.1093/ve/vew036.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566081PMC
March 2017

Structural basis of anti-PD-L1 monoclonal antibody avelumab for tumor therapy.

Cell Res 2017 01 30;27(1):151-153. Epub 2016 Aug 30.

College of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.

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http://dx.doi.org/10.1038/cr.2016.102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223223PMC
January 2017

T-cell immunity of SARS-CoV: Implications for vaccine development against MERS-CoV.

Antiviral Res 2017 01 11;137:82-92. Epub 2016 Nov 11.

National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing, 100052, China; Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People's Hospital, Shenzhen, 518112, China; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, 100101, China; University of Chinese Academy of Sciences, Beijing, 100049, China; Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, 100101, China. Electronic address:

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http://dx.doi.org/10.1016/j.antiviral.2016.11.006DOI Listing
January 2017

The recombinant N-terminal domain of spike proteins is a potential vaccine against Middle East respiratory syndrome coronavirus (MERS-CoV) infection.

Vaccine 2017 01 26;35(1):10-18. Epub 2016 Nov 26.

Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, China CDC, Beijing 102206, China. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2016.11.064DOI Listing
January 2017

Characterization of anti-MERS-CoV antibodies against various recombinant structural antigens of MERS-CoV in an imported case in China.

Emerg Microbes Infect 2016 Nov 9;5(11):e113. Epub 2016 Nov 9.

Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.

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http://dx.doi.org/10.1038/emi.2016.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148018PMC
November 2016

Safe and Sensitive Antiviral Screening Platform Based on Recombinant Human Coronavirus OC43 Expressing the Luciferase Reporter Gene.

Antimicrob Agents Chemother 2016 09 22;60(9):5492-503. Epub 2016 Aug 22.

Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China

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http://dx.doi.org/10.1128/AAC.00814-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997878PMC
September 2016

Genetic characterization of human bocavirus among children with severe acute respiratory infection in China.

J Infect 2016 08 13;73(2):155-63. Epub 2016 Jun 13.

Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, China CDC, Beijing 102206, China. Electronic address:

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http://dx.doi.org/10.1016/j.jinf.2016.05.014DOI Listing
August 2016

Prevalence and phylogenetic characterization of canine coronavirus from diseased pet dogs in Beijing, China.

Sci China Life Sci 2016 Aug 12;59(8):860-2. Epub 2016 May 12.

Key Laboratory of Medical Virology, National Health and Family Planning Commission, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.

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http://dx.doi.org/10.1007/s11427-015-0369-xDOI Listing
August 2016

Genetic and antigenic characterization of recombinant nucleocapsid proteins derived from canine coronavirus and canine respiratory coronavirus in China.

Sci China Life Sci 2016 Jun 15;59(6):615-21. Epub 2016 Apr 15.

Institute of Medical Virology, Wenzhou Medical University, Wenzhou, 325035, China.

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http://dx.doi.org/10.1007/s11427-016-5038-1DOI Listing
June 2016

[Advances in the Animal Models of MERS-CoV].

Bing Du Xue Bao 2016 05;32(3):369-75

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May 2016

Structure of Main Protease from Human Coronavirus NL63: Insights for Wide Spectrum Anti-Coronavirus Drug Design.

Sci Rep 2016 Mar 7;6:22677. Epub 2016 Mar 7.

School of Life Sciences, Tianjin University, Tianjin 300072, China.

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http://dx.doi.org/10.1038/srep22677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780191PMC
March 2016

Phylogenetic evidence for intratypic recombinant events in a novel human adenovirus C that causes severe acute respiratory infection in children.

Sci Rep 2016 Mar 10;6:23014. Epub 2016 Mar 10.

Key Laboratory of Medical Virology, Ministry of Health; National Institute for Viral Disease Control and Prevention, China CDC, Beijing 102206, China.

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http://dx.doi.org/10.1038/srep23014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785336PMC
March 2016

Two-tube multiplex real-time reverse transcription PCR to detect six human coronaviruses.

Virol Sin 2016 Feb;31(1):85-8

Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.

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http://dx.doi.org/10.1007/s12250-015-3653-9DOI Listing
February 2016

Molecular typing and epidemiology profiles of human adenovirus infection among paediatric patients with severe acute respiratory infection in China.

PLoS One 2015 9;10(4):e0123234. Epub 2015 Apr 9.

Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0123234PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391708PMC
December 2015

Middle East respiratory syndrome coronavirus ORF4b protein inhibits type I interferon production through both cytoplasmic and nuclear targets.

Sci Rep 2015 Dec 3;5:17554. Epub 2015 Dec 3.

Key Laboratory of Medical Virology, Ministry of Health; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.

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http://mbio.asm.org/content/7/2/e00258-16.full.pdf
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http://www.nature.com/articles/srep17554
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http://dx.doi.org/10.1038/srep17554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668369PMC
December 2015

Human herpes viruses are associated with classic fever of unknown origin (FUO) in Beijing patients.

PLoS One 2014 3;9(7):e101619. Epub 2014 Jul 3.

Key Laboratory of Medical Virology, Ministry of Health; National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0101619PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081597PMC
November 2015

Complete Genome Sequence of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) from the First Imported MERS-CoV Case in China.

Genome Announc 2015 Aug 13;3(4). Epub 2015 Aug 13.

Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China

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http://dx.doi.org/10.1128/genomeA.00818-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536671PMC
August 2015

Recombinant Receptor Binding Domain Protein Induces Partial Protective Immunity in Rhesus Macaques Against Middle East Respiratory Syndrome Coronavirus Challenge.

EBioMedicine 2015 Oct 18;2(10):1438-46. Epub 2015 Aug 18.

Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, China CDC, Beijing 102206, China.

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http://dx.doi.org/10.1016/j.ebiom.2015.08.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634622PMC
October 2015

Origin and Possible Genetic Recombination of the Middle East Respiratory Syndrome Coronavirus from the First Imported Case in China: Phylogenetics and Coalescence Analysis.

MBio 2015 Sep 8;6(5):e01280-15. Epub 2015 Sep 8.

Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China

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http://dx.doi.org/10.1128/mBio.01280-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600111PMC
September 2015

Systemic and mucosal immunity in mice elicited by a single immunization with human adenovirus type 5 or 41 vector-based vaccines carrying the spike protein of Middle East respiratory syndrome coronavirus.

Immunology 2015 Aug 21;145(4):476-84. Epub 2015 Apr 21.

Key Laboratory of Medical Virology, Ministry of Health; National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China.

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http://dx.doi.org/10.1111/imm.12462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515128PMC
August 2015

Complete Genome Sequence of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) from the First Imported MERS-CoV Case in China.

Genome Announc 2015 Aug 13;3(4). Epub 2015 Aug 13.

Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China

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http://dx.doi.org/10.1128/genomeA.00818-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536671PMC
August 2015

Protective Efficacy of the Conserved NP, PB1, and M1 Proteins as Immunogens in DNA- and Vaccinia Virus-Based Universal Influenza A Virus Vaccines in Mice.

Clin Vaccine Immunol 2015 Jun 1;22(6):618-30. Epub 2015 Apr 1.

National Institute for Viral Disease Control & Prevention, Chinese Center for Disease Control and Prevention (China CDC), Chang Ping District, Beijing, China

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http://dx.doi.org/10.1128/CVI.00091-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446406PMC
June 2015

[Advances in the researches of genomic characterization and molecular detection of Middel East respiratory syndrome coronavirus].

Zhonghua Yu Fang Yi Xue Za Zhi 2015 May;49(5):461-4

Institute of Medical Virology, Wenzhou Medical University, Wenzhou 325035, China; Email:

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May 2015

Prevalence and genetic diversity analysis of human coronavirus OC43 among adult patients with acute respiratory infections in Beijing, 2012.

PLoS One 2014 2;9(7):e100781. Epub 2014 Jul 2.

Institute of Medical Virology, Wenzhou Medical University, Zhejiang, China; Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0100781PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079595PMC
February 2015

Reply to "Detection of human herpesviruses (HHVs) DNA in blood samples: a true marker of Fever of Unknown Origin (FUO)?".

J Clin Virol 2014 Dec 30;61(4):619-20. Epub 2014 Sep 30.

Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, China CDC, Beijing 102206, China. Electronic address:

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http://dx.doi.org/10.1016/j.jcv.2014.09.011DOI Listing
December 2014

The amino acids 736-761 of the MERS-CoV spike protein induce neutralizing antibodies: implications for the development of vaccines and antiviral agents.

Viral Immunol 2014 Dec;27(10):543-50

1 Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention , Chinese Centers for Disease Control and Prevention, Beijing, China .

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http://dx.doi.org/10.1089/vim.2014.0080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259179PMC
December 2014

A novel method for synthetic vaccine construction based on protein assembly.

Sci Rep 2014 Dec 1;4:7266. Epub 2014 Dec 1.

Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.

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http://dx.doi.org/10.1038/srep07266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248271PMC
December 2014

Maximal immune response and cross protection by influenza virus nucleoprotein derived from E. coli using an optimized formulation.

Virology 2014 Nov 12;468-470:265-273. Epub 2014 Sep 12.

National Institute for Viral Disease Control & Prevention, Chinese Center for Disease Control and Prevention (China CDC), 155# Chang Bai Road, Chang Ping District, Beijing 102206, China. Electronic address:

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http://dx.doi.org/10.1016/j.virol.2014.08.008DOI Listing
November 2014

Development of a new resequencing pathogen microarray based assay for detection of broad-spectrum respiratory tract viruses in patients with community-acquired pneumonia.

PLoS One 2013 27;8(9):e75704. Epub 2013 Sep 27.

Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China ; Futian District Center for Disease Control and Prevention, Shenzhen, Guangdong, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0075704PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785410PMC
July 2014

Prevalence of herpes and respiratory viruses in induced sputum among hospitalized children with non typical bacterial community-acquired pneumonia.

PLoS One 2013 18;8(11):e79477. Epub 2013 Nov 18.

Key Laboratory of Medical Virology, Ministry of Health; National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0079477PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832587PMC
July 2014

Viral etiology and clinical profiles of children with severe acute respiratory infections in China.

PLoS One 2013 22;8(8):e72606. Epub 2013 Aug 22.

Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, China Centers for Disease Control and Prevention (CDC), Beijing, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0072606PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750056PMC
June 2014

Lentiviral backbone-based hepatitis B virus replicon-mediated transfer favours the establishment of persistent hepatitis B virus infection in mice after hydrodynamic injection.

Antiviral Res 2014 Jan 12;101:68-74. Epub 2013 Nov 12.

Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.antiviral.2013.10.019DOI Listing
January 2014

Structure of the fusion core and inhibition of fusion by a heptad repeat peptide derived from the S protein of Middle East respiratory syndrome coronavirus.

J Virol 2013 Dec 25;87(24):13134-40. Epub 2013 Sep 25.

CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.

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http://dx.doi.org/10.1128/JVI.02433-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838252PMC
December 2013

The structural and accessory proteins M, ORF 4a, ORF 4b, and ORF 5 of Middle East respiratory syndrome coronavirus (MERS-CoV) are potent interferon antagonists.

Protein Cell 2013 Dec 8;4(12):951-61. Epub 2013 Dec 8.

Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.

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http://dx.doi.org/10.1007/s13238-013-3096-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4875403PMC
December 2013

Induction of broadly neutralising HCV antibodies in mice by integration-deficient lentiviral vector-based pseudotyped particles.

PLoS One 2013 23;8(4):e62684. Epub 2013 Apr 23.

Key Laboratory of Medical Virology and Viral Diseases, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping District, Beijing, People's Republic of China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0062684PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633868PMC
November 2013

The novel replication-defective vaccinia virus (Tiantan strain)-based hepatitis C virus vaccine induces robust immunity in macaques.

Mol Ther 2013 Sep 18;21(9):1787-95. Epub 2013 Jun 18.

National Engineering Laboratory for AIDS Vaccine, College of Life Science, Jilin University, Changchun, China.

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http://dx.doi.org/10.1038/mt.2013.122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776631PMC
September 2013

First infection by all four non-severe acute respiratory syndrome human coronaviruses takes place during childhood.

BMC Infect Dis 2013 Sep 16;13:433. Epub 2013 Sep 16.

Key Laboratory of Medical Virology, Ministry of Health; National Institute for Viral Disease Control and Prevention, China Centers for Disease Control and Prevention, Beijing 102206, China.

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http://dx.doi.org/10.1186/1471-2334-13-433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848659PMC
September 2013

A novel human coronavirus: Middle East respiratory syndrome human coronavirus.

Sci China Life Sci 2013 Aug 7;56(8):683-7. Epub 2013 Aug 7.

Biotech Center for Viral Disease Emergency, Key Laboratory of Medical Virology and Viral Diseases Prevention and Control, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.

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http://dx.doi.org/10.1007/s11427-013-4519-8DOI Listing
August 2013

Robust immunity and heterologous protection against influenza in mice elicited by a novel recombinant NP-M2e fusion protein expressed in E. coli.

PLoS One 2012 21;7(12):e52488. Epub 2012 Dec 21.

National Institute for Viral Disease Control & Prevention, Chinese Center for Disease Control and Prevention, China CDC, Beijing, People's Republic of China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0052488PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528677PMC
June 2013

Poly(I:C)/alum mixed adjuvant priming enhances HBV subunit vaccine-induced immunity in mice when combined with recombinant adenoviral-based HBV vaccine boosting.

PLoS One 2013 15;8(1):e54126. Epub 2013 Jan 15.

National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0054126PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3545998PMC
June 2013

Optimisation of prime-boost immunization in mice using novel protein-based and recombinant vaccinia (Tiantan)-based HBV vaccine.

PLoS One 2012 6;7(9):e43730. Epub 2012 Sep 6.

Biotech Center for Viral Diseases Emergency, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0043730PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435326PMC
May 2013

Induction of humoral and cellular immune responses against hepatitis C virus by vaccination with replicon particles derived from Sindbis-like virus XJ-160.

Arch Virol 2013 May 19;158(5):1013-9. Epub 2012 Dec 19.

State Key Laboratory for Infectious Disease Prevention and Control, The Department of Viral Encephalitis, National Institute for Viral Disease Control and Prevention, Chinese Center for Viral Disease Control and Prevention China CDC, Changbai Road 155, Changping District, Beijing, 102206, People's Republic of China.

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http://dx.doi.org/10.1007/s00705-012-1564-8DOI Listing
May 2013

Insect cell-expressed hemagglutinin with CpG oligodeoxynucleotides plus alum as an adjuvant is a potential pandemic influenza vaccine candidate.

Vaccine 2012 Dec 29;30(52):7498-505. Epub 2012 Oct 29.

Department of Virology, National Vaccine and Serum Institute, Beijing 100024, China.

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http://dx.doi.org/10.1016/j.vaccine.2012.10.054DOI Listing
December 2012

Influenza A virus nucleoprotein derived from Escherichia coli or recombinant vaccinia (Tiantan) virus elicits robust cross-protection in mice.

Virol J 2012 Dec 29;9:322. Epub 2012 Dec 29.

Biotech Center for Viral Disease Emergency, National Institute for Viral Disease Control and Prevention (IVDC), Chinese Center for Disease Control and Prevention (CCDC), Changbai Road 155, Changping District, Beijing, 102206, People's Republic of China.

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http://dx.doi.org/10.1186/1743-422X-9-322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547759PMC
December 2012

Characterization and complete genome sequence of human coronavirus NL63 isolated in China.

J Virol 2012 Sep;86(17):9546-7

Biotech Center for Viral Disease Emergency, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China.

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http://dx.doi.org/10.1128/JVI.01457-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3416104PMC
September 2012

Etiology and clinical characterization of respiratory virus infections in adult patients attending an emergency department in Beijing.

PLoS One 2012 28;7(2):e32174. Epub 2012 Feb 28.

Key Laboratory for Laboratory Medicine of Ministry of Education, Institute of Medical Virology, Wenzhou Medical College, Wenzhou, Zhejiang, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0032174PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289638PMC
July 2012

Enhanced effect of DNA immunization plus in vivo electroporation with a combination of hepatitis B virus core-PreS1 and S-PreS1 plasmids.

Clin Vaccine Immunol 2011 Nov 7;18(11):1789-95. Epub 2011 Sep 7.

State Key Laboratory for Molecular Virology and Genetic Engineering, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, 100 Yingxin Street, Xuanwu District, Beijing 100052, People's Republic of China.

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http://dx.doi.org/10.1128/CVI.05113-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3209024PMC
November 2011

Effect of route of delivery on heterologous protection against HCV induced by an adenovirus vector carrying HCV structural genes.

Virol J 2011 Nov 4;8:506. Epub 2011 Nov 4.

State Key Laboratory for Molecular Virology and Genetic Engineering, National Institute for Viral Disease Control and Prevention, Chinese Centre for Disease Control and Prevention, Changbai Road 155, Changping District, Beijing 102206, People's Republic of China.

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http://dx.doi.org/10.1186/1743-422X-8-506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225406PMC
November 2011

Immunogenicity in mice and rhesus monkeys vaccinated with recombinant vaccinia virus expressing bivalent E7E6 fusion proteins from human papillomavirus types 16 and 18.

Virol J 2011 Jun 15;8:302. Epub 2011 Jun 15.

State Key Laboratory for Molecular Virology and Genetic Engineering, Biotech Center for Viral Disease Emergency, National Institute for Viral Disease Control and Prevention, China CDC, Changpingqu, Beijing 102206, China.

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http://dx.doi.org/10.1186/1743-422X-8-302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135557PMC
June 2011

Signal peptide replacements enhance expression and secretion of hepatitis C virus envelope glycoproteins.

Acta Biochim Biophys Sin (Shanghai) 2011 Feb 31;43(2):96-102. Epub 2010 Dec 31.

Wenzhou Medical College, Wenzhou, China.

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http://dx.doi.org/10.1093/abbs/gmq117DOI Listing
February 2011

Strong influence of human leukocyte antigen (HLA)-DP gene variants on development of persistent chronic hepatitis B virus carriers in the Han Chinese population.

Hepatology 2011 Feb 4;53(2):422-8. Epub 2011 Jan 4.

Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Science, Wenzhou Medical College, Zhejiang, China.

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http://dx.doi.org/10.1002/hep.24048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056070PMC
February 2011

[Boosting with HBV subunit particle vaccine enhance immune response of novel DNA vaccine consisting of S-PreS1 fusion gene in mice].

Sheng Wu Gong Cheng Xue Bao 2011 Jan;27(1):95-100

Biotech Center for Viral Diseases Emergency, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100052, China.

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January 2011

Characterization of antibodies specific for hemagglutinin and neuraminidase proteins of the 1918 and 2009 pandemic H1N1 viruses.

Vaccine 2010 Dec 4;29(2):183-90. Epub 2010 Nov 4.

Department of Microbiology, Shanghai Key Laboratory of Medical Biodefense, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, PR China.

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http://linkinghub.elsevier.com/retrieve/pii/S0264410X1001560
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http://dx.doi.org/10.1016/j.vaccine.2010.10.059DOI Listing
December 2010

Characterization of neuraminidases from the highly pathogenic avian H5N1 and 2009 pandemic H1N1 influenza A viruses.

PLoS One 2010 Dec 29;5(12):e15825. Epub 2010 Dec 29.

Key Laboratory for Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Science, Wenzhou Medical College, Wenzhou, People's Republic of China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0015825PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012118PMC
December 2010

[Impact of different adjuvants on immunogenicity of the HBV particle vaccine containing the S + preS1 fusion antigen in Balb/C mice].

Sheng Wu Gong Cheng Xue Bao 2010 Jan;26(1):74-8

Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100052, China.

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January 2010

[Real time ex vivo detection and dynamic monitoring of in vivo expression of secreted luciferase gene injected by hydrodynamic method].

Sheng Wu Gong Cheng Xue Bao 2009 Oct;25(10):1552-7

Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, National Laboratory of Molecular Virology and Genetic Engineering, Beijing 100052, China.

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October 2009