Wenhui Hu

Wenhui Hu

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Wenhui Hu

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Der p2‑A20 DNA vaccine attenuates allergic inflammation in mice with allergic rhinitis.

Mol Med Rep 2019 Dec 21;20(6):4925-4932. Epub 2019 Oct 21.

Department of Otolaryngology, Longgang ENT Hospital and Shenzhen Key Laboratory of ENT, Institute of ENT, Shenzhen, Guangdong 518172, P.R. China.

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http://dx.doi.org/10.3892/mmr.2019.10760DOI Listing
December 2019

Predictive serum markers for unexplained infertility in child-bearing aged women.

Am J Reprod Immunol 2019 Oct 4:e13194. Epub 2019 Oct 4.

Jinxin Research Institute for Reproductive Medicine and Genetics, Chengdu Jinjiang Hospital for Maternal and Child Health Care, Chengdu, China.

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http://dx.doi.org/10.1111/aji.13194DOI Listing
October 2019

Mechanical Point Loading Induces Cortex Stiffening and Actin Reorganization.

Biophys J 2019 Oct 17;117(8):1405-1418. Epub 2019 Sep 17.

Center of Biomechanics and Bioengineering, Key Laboratory of Microgravity (National Microgravity Laboratory), Beijing Key Laboratory of Engineered Construction and Mechanobiology, and CAS Center for Excellence in Complex System Mechanics, Institute of Mechanics, Chinese Academy of Sciences, Beijing, China; School of Engineering Science, University of Chinese Academy of Sciences, Beijing, China. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2019.09.012DOI Listing
October 2019

Sex-specific neurogenic deficits and neurocognitive disorders in middle-aged HIV-1 Tg26 transgenic mice.

Brain Behav Immun 2019 Aug 16;80:488-499. Epub 2019 Apr 16.

Center for Metabolic Disease Research, Temple University Lewis Katz School of Medicine, 3500 N Broad Street, Philadelphia, PA 19140, United States; Department of Pathology and Laboratory Medicine, Temple University Lewis Katz School of Medicine, 3500 N Broad Street, Philadelphia, PA 19140, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08891591183060
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http://dx.doi.org/10.1016/j.bbi.2019.04.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660421PMC
August 2019

HIV-1 and Compromised Adult Neurogenesis: Emerging Evidence for a New Paradigm of HAND Persistence

AIDS Rev 2019 ;21(1):11-22

Department of Pathology and Laboratory Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.24875/AIDSRev.19000003DOI Listing
July 2019

pVAX1-A20 alleviates colitis in mice by promoting regulatory T cells.

Dig Liver Dis 2019 06 17;51(6):790-797. Epub 2018 Nov 17.

Longgang ENT Hospital, Institute of ENT and Shenzhen Key Laboratory of ENT, Shenzhen, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15908658183122
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http://dx.doi.org/10.1016/j.dld.2018.11.005DOI Listing
June 2019

Phenotypic Characterization of Very Early-Onset Inflammatory Bowel Disease with Interleukin-10 Signaling Deficiency: Based on a Large Cohort Study.

Inflamm Bowel Dis 2019 03;25(4):756-766

Department of Gastroenterology, Pediatric Inflammatory Bowel Disease Research Center, Children's Hospital of Fudan University, Shanghai, China.

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http://dx.doi.org/10.1093/ibd/izy289DOI Listing
March 2019

GATA3, HDAC6, and BCL6 Regulate FOXP3+ Treg Plasticity and Determine Treg Conversion into Either Novel Antigen-Presenting Cell-Like Treg or Th1-Treg.

Front Immunol 2018 26;9:45. Epub 2018 Jan 26.

Center for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.

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http://dx.doi.org/10.3389/fimmu.2018.00045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790774PMC
February 2019

Co-signaling receptors regulate T-cell plasticity and immune tolerance.

Front Biosci (Landmark Ed) 2019 01 1;24:96-132. Epub 2019 Jan 1.

Centers for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, U.S.A.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309335PMC
January 2019

Identifying the Multielectron Effect on Chemical Bond Rearrangement of CHCl Molecules in Strong Laser Fields.

J Phys Chem A 2018 Nov 19;122(43):8427-8432. Epub 2018 Oct 19.

Institute of Atomic and Molecular Physics, Jilin Provincial Key Laboratory of Applied Atomic and Molecular Spectroscopy , Jilin University , Changchun 130012 , P. R. China.

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http://pubs.acs.org/doi/10.1021/acs.jpca.8b06415
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http://dx.doi.org/10.1021/acs.jpca.8b06415DOI Listing
November 2018

2D Covalent Organic Frameworks as Intrinsic Photocatalysts for Visible Light-Driven CO Reduction.

J Am Chem Soc 2018 Nov 25;140(44):14614-14618. Epub 2018 Oct 25.

Department of Chemistry , Marquette University , Milwaukee , Wisconsin 53201 , United States.

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http://dx.doi.org/10.1021/jacs.8b09705DOI Listing
November 2018

Adult neurogenic deficits in HIV-1 Tg26 transgenic mice.

J Neuroinflammation 2018 Oct 12;15(1):287. Epub 2018 Oct 12.

Center for Metabolic Disease Research, Temple University Lewis Katz School of Medicine, 3500 N Broad Street, Philadelphia, PA, 19140, USA.

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https://jneuroinflammation.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s12974-018-1322-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182864PMC
October 2018

Direct Observation of Node-to-Node Communication in Zeolitic Imidazolate Frameworks.

J Am Chem Soc 2018 09 6;140(37):11573-11576. Epub 2018 Sep 6.

Department of Chemistry , Marquette University , Milwaukee , Wisconsin 53201 , United States.

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http://dx.doi.org/10.1021/jacs.8b06727DOI Listing
September 2018

Phenotypic Characterization of Very Early-Onset Inflammatory Bowel Disease with Interleukin-10 Signaling Deficiency: Based on a Large Cohort Study.

Inflamm Bowel Dis 2019 03;25(4):756-766

Department of Gastroenterology, Pediatric Inflammatory Bowel Disease Research Center, Children's Hospital of Fudan University, Shanghai, China.

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http://dx.doi.org/10.1093/ibd/izy289DOI Listing
March 2019

Discovery of Highly Potent Pinanamine-Based Inhibitors against Amantadine- and Oseltamivir-Resistant Influenza A Viruses.

J Med Chem 2018 06 11;61(12):5187-5198. Epub 2018 Jun 11.

State Key Laboratory of Respiratory Disease, Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences & The Fifth Affiliated Hospital , Guangzhou Medical University , Guangzhou 511436 , P. R. China.

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http://pubs.acs.org/doi/10.1021/acs.jmedchem.8b00042
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http://dx.doi.org/10.1021/acs.jmedchem.8b00042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6496959PMC
June 2018

Pinanamine Is a Promising Lead Compound against Influenza A Virus: Evidence from in Vitro and in Vivo Efficacy Compared to Amantadine.

Biol Pharm Bull 2017 ;40(7):954-959

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University (Guangzhou Medical University).

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http://dx.doi.org/10.1248/bpb.b16-00774DOI Listing
May 2018

Cappariloside A shows antiviral and better anti-inflammatory effects against influenza virus via regulating host IFN signaling, in vitro and vivo.

Life Sci 2018 May 17;200:115-125. Epub 2018 Mar 17.

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, (Guangzhou Medical University), Guangzhou 510120, China; Macau University of Science and Technology, Macau 519020, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00243205183013
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http://dx.doi.org/10.1016/j.lfs.2018.03.033DOI Listing
May 2018

Lymphotoxin β receptor-mediated NFκB signaling promotes glial lineage differentiation and inhibits neuronal lineage differentiation in mouse brain neural stem/progenitor cells.

J Neuroinflammation 2018 Feb 20;15(1):49. Epub 2018 Feb 20.

Center for Metabolic Disease Research, Department of Pathology and Laboratory Medicine, Temple University Lewis Katz School of Medicine, 3500 N Broad Street, Philadelphia, PA, 19140, USA.

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http://dx.doi.org/10.1186/s12974-018-1074-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819232PMC
February 2018

Rapid generation of a novel DPP-4 inhibitor with long-acting properties: SAR study and PK/PD evaluation.

Eur J Med Chem 2017 Dec 12;141:519-529. Epub 2017 Oct 12.

Key Laboratory of Molecular Clinical Pharmacology, School of Pharmaceutical Sciences & The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, China; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Science, 190 Kaiyuan Avenue, Guangzhou 510530, China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2017.10.029DOI Listing
December 2017

Increased autophagic degradation contributes to the neuroprotection of hydrogen sulfide against cerebral ischemia/reperfusion injury.

Metab Brain Dis 2017 10 18;32(5):1449-1458. Epub 2017 Apr 18.

Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, China.

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http://dx.doi.org/10.1007/s11011-017-0014-4DOI Listing
October 2017

[A numerical simulation of dendritic cells migration and induction of T cell specific proliferation during the initiation of skin inflammatory].

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2017 Oct;34(5):797-802

School of Biology and Engineering, Guizhou Medical University, Guiyang 550025, P.R.China;Key laboratory of Biology and Engineering, Guizhou Medical University, Guiyang 550025,

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http://dx.doi.org/10.7507/1001-5515.201702050DOI Listing
October 2017

Molecular cloning and characterization of the genes encoding the proteins of Zika virus.

Gene 2017 Sep 15;628:117-128. Epub 2017 Jul 15.

Department of Microbiology, Howard University College of Medicine, Seeley Mudd Building, 520 W Street, NW, Washington, DC 20059, United States. Electronic address:

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http://dx.doi.org/10.1016/j.gene.2017.07.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729740PMC
September 2017

Multielectron Effects in the Strong Field Sequential Ionization of Aligned CHI Molecules.

J Phys Chem A 2017 Sep 24;121(35):6547-6553. Epub 2017 Aug 24.

Institute of Atomic and Molecular Physics, and Jilin Provincial Key Laboratory of Applied Atomic and Molecular Spectroscopy, Jilin University , Changchun 130012, China.

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http://dx.doi.org/10.1021/acs.jpca.7b05588DOI Listing
September 2017

HIV-1 Latency and Eradication: Past, Present and Future.

Curr HIV Res 2016 ;14(5):431-441

Department of Neuroscience, Center for Neurovirology and Comprehensive NeuroAIDS Center, Lewis Katz School of Medicine at Temple University, 3500 N. Broad Street, 7th Floor, Philadelphia, PA 19140, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5157928PMC
http://dx.doi.org/10.2174/1570162x14666160324125536DOI Listing
August 2017

Ultrafast proton migration and Coulomb explosion of methyl chloride in intense laser fields.

J Chem Phys 2017 Jun;146(24):244305

Institute of Atomic and Molecular Physics, Jilin University, Changchun 130012, People's Republic of China and Jilin Provincial Key Laboratory of Applied Atomic and Molecular Spectroscopy, Jilin University, Changchun 130012, People's Republic of China.

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http://dx.doi.org/10.1063/1.4989565DOI Listing
June 2017

In Vivo Excision of HIV-1 Provirus by saCas9 and Multiplex Single-Guide RNAs in Animal Models.

Mol Ther 2017 05 30;25(5):1168-1186. Epub 2017 Mar 30.

Department of Neuroscience, Center for Neurovirology and the Comprehensive NeuroAIDS Center, Temple University Lewis Katz School of Medicine, 3500 N. Broad Street, Philadelphia, PA 19140, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15250016173011
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http://dx.doi.org/10.1016/j.ymthe.2017.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417847PMC
May 2017

Regulator of G protein signaling 4 is a novel target of GATA-6 transcription factor.

Biochem Biophys Res Commun 2017 02 13;483(3):923-929. Epub 2016 Oct 13.

Department of Neuroscience, Temple University Lewis Katz School of Medicine, 3500 N Broad Street, Philadelphia, PA 19140, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2016.10.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5266638PMC
February 2017

Rotational Dynamics of Quantum State-Selected Symmetric-Top Molecules in Nonresonant Femtosecond Laser Fields.

J Phys Chem A 2017 Feb 23;121(4):777-783. Epub 2017 Jan 23.

Institute of Atomic and Molecular Physics, Jilin University , Changchun 130012, China.

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http://dx.doi.org/10.1021/acs.jpca.6b11209DOI Listing
February 2017

Analyses of caspase-1-regulated transcriptomes in various tissues lead to identification of novel IL-1β-, IL-18- and sirtuin-1-independent pathways.

J Hematol Oncol 2017 02 2;10(1):40. Epub 2017 Feb 2.

Centers for Metabolic Disease Research and Cardiovascular Research, Lewis Katz School of Medicine at Temple University, 3500 North Broad Street, MERB-1059, Philadelphia, PA, 19140, USA.

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http://dx.doi.org/10.1186/s13045-017-0406-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290602PMC
February 2017

Determination of fenticonazole in human plasma by HPLC-MS/MS and its application to pharmacokinetic studies.

J Pharm Anal 2017 Feb 8;7(1):63-70. Epub 2016 Sep 8.

Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China.

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https://linkinghub.elsevier.com/retrieve/pii/S20951779163007
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http://dx.doi.org/10.1016/j.jpha.2016.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686869PMC
February 2017

Identification of AcAP5 as a novel factor Xa inhibitor with both direct and allosteric inhibition.

Biochem Biophys Res Commun 2017 01 19;483(1):495-501. Epub 2016 Dec 19.

Department of Molecular and Cellular Pharmacology, Peking University School of Pharmaceutical Sciences, Beijing, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2016.12.116DOI Listing
January 2017

Gene Editing Approaches against Viral Infections and Strategy to Prevent Occurrence of Viral Escape.

PLoS Pathog 2016 12 8;12(12):e1005953. Epub 2016 Dec 8.

Department of Neuroscience, Center for Neurovirology and Comprehensive NeuroAIDS Center, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1005953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5145235PMC
December 2016

Microglia-Based Phenotypic Screening Identifies a Novel Inhibitor of Neuroinflammation Effective in Alzheimer's Disease Models.

ACS Chem Neurosci 2016 11 2;7(11):1499-1507. Epub 2016 Sep 2.

State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , Guangzhou 510530, People's Republic of China.

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http://dx.doi.org/10.1021/acschemneuro.6b00125DOI Listing
November 2016

Negative Feedback Regulation of HIV-1 by Gene Editing Strategy.

Sci Rep 2016 08 16;6:31527. Epub 2016 Aug 16.

Department of Neuroscience Center for Neurovirology, Lewis Katz School of Medicine at Temple University, 3500 N. Broad Street, 7th Floor Philadelphia, PA 19140, USA.

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http://dx.doi.org/10.1038/srep31527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985742PMC
August 2016

Immune/Inflammatory Response and Hypocontractility of Rabbit Colonic Smooth Muscle After TNBS-Induced Colitis.

Dig Dis Sci 2016 07 15;61(7):1925-40. Epub 2016 Feb 15.

Department of Neuroscience, Temple University School of Medicine, 3500 N Broad Street, Philadelphia, PA, 19140, USA.

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http://dx.doi.org/10.1007/s10620-016-4078-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920730PMC
July 2016

Gene Editing for Treatment of Neurological Infections.

Neurotherapeutics 2016 07;13(3):547-54

Department of Neuroscience, Center for Neurovirology, Comprehensive NeuroAIDS Center, Lewis Katz School of Medicine at Temple University, 3500 N. Broad Street, 7th Floor, Philadelphia, PA, 19140, USA.

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http://dx.doi.org/10.1007/s13311-016-0439-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965407PMC
July 2016

CRISPR/Cas9 System as an Agent for Eliminating Polyomavirus JC Infection.

PLoS One 2015 11;10(9):e0136046. Epub 2015 Sep 11.

Department of Neuroscience, Temple University School of Medicine, Philadelphia, PA, 19122, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0136046PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567079PMC
May 2016

Development and validation of a cyclodextrin-modified capillary electrophoresis method for the enantiomeric separation of vildagliptin enantiomers.

Electrophoresis 2016 May 10;37(10):1318-25. Epub 2016 Mar 10.

Department of Pharmacognosy, Semmelweis University, Budapest, Hungary.

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http://dx.doi.org/10.1002/elps.201500442DOI Listing
May 2016

Functional screening of guide RNAs targeting the regulatory and structural HIV-1 viral genome for a cure of AIDS.

AIDS 2016 05;30(8):1163-74

aDepartment of Neuroscience, Center for Neurovirology and The Comprehensive NeuroAIDS Center, Temple University School of Medicine, Philadelphia bDepartment of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. *Kamel Khalili, Wenhui Hu and Yonggang Zhang are senior authors and have equally contributed to this manuscript.

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http://dx.doi.org/10.1097/QAD.0000000000001079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851589PMC
May 2016

Type I bHLH Proteins Daughterless and Tcf4 Restrict Neurite Branching and Synapse Formation by Repressing Neurexin in Postmitotic Neurons.

Cell Rep 2016 Apr 31;15(2):386-97. Epub 2016 Mar 31.

Department of Biology, Drexel University, Philadelphia, PA 19104, USA; Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.03.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946342PMC
April 2016

Elimination of HIV-1 Genomes from Human T-lymphoid Cells by CRISPR/Cas9 Gene Editing.

Sci Rep 2016 Mar 4;6:22555. Epub 2016 Mar 4.

Department of Neuroscience/Center for Neurovirology, Lewis Katz School of Medicine at Temple University, 3500 N. Broad Street, 7th Floor, Philadelphia, PA 19140 USA.

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http://dx.doi.org/10.1038/srep22555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778041PMC
March 2016

Imidazole-based pinanamine derivatives: Discovery of dual inhibitors of the wild-type and drug-resistant mutant of the influenza A virus.

Eur J Med Chem 2016 Jan 15;108:605-615. Epub 2015 Dec 15.

State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Guangzhou 510530, China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2015.12.013DOI Listing
January 2016

CRISPR/gRNA-directed synergistic activation mediator (SAM) induces specific, persistent and robust reactivation of the HIV-1 latent reservoirs.

Sci Rep 2015 Nov 5;5:16277. Epub 2015 Nov 5.

Department of Neuroscience, Center for Neurovirology and The Comprehensive NeuroAIDS Center, Temple University School of Medicine, 3500 N Broad Street, Philadelphia, PA 19140.

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http://dx.doi.org/10.1038/srep16277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633726PMC
November 2015

C-Aryl glucoside SGLT2 inhibitors containing a biphenyl motif as potential anti-diabetic agents.

Bioorg Med Chem Lett 2015 Jul 27;25(14):2744-8. Epub 2015 May 27.

State Key Laboratory of Respiratory Disease, Institutes of Biomedicine and Health, Chinese Academy of Science, 190 Kaiyuan Avenue, Guangzhou Science Park, Guangzhou 510530, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X150050
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http://dx.doi.org/10.1016/j.bmcl.2015.05.040DOI Listing
July 2015

Neuroprotective effect of TAT-14-3-3ε fusion protein against cerebral ischemia/reperfusion injury in rats.

PLoS One 2014 26;9(3):e93334. Epub 2014 Mar 26.

Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University, Beijing, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0093334PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966873PMC
June 2015

Genome editing strategies: potential tools for eradicating HIV-1/AIDS.

J Neurovirol 2015 Jun 26;21(3):310-21. Epub 2015 Feb 26.

Department of Neuroscience, Center for Neurovirology and the Comprehensive NeuroAIDS Center, Temple University School of Medicine, Philadelphia, PA, 19140, USA,

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http://dx.doi.org/10.1007/s13365-014-0308-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433555PMC
June 2015

Structure-guided creation of AcAP5-derived and platelet targeted factor Xa inhibitors.

Biochem Pharmacol 2015 Jun 15;95(4):253-62. Epub 2015 Apr 15.

Department of Molecular and Cellular Pharmacology, State Key Laboratory of Natural and Biomimetic Drugs, Peking University School of Pharmaceutical Sciences, Beijing, China. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2015.04.004DOI Listing
June 2015

The CRISPR/Cas9 genome editing methodology as a weapon against human viruses.

Discov Med 2015 Apr;19(105):255-62

Department of Neuroscience, Temple University School of Medicine, Philadelphia, PA 19140, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445958PMC
April 2015

Separation of alogliptin enantiomers in cyclodextrin-modified capillary electrophoresis: a validated method.

Electrophoresis 2014 Oct 13;35(19):2885-91. Epub 2014 Apr 13.

Department of Pharmaceutical Chemistry, Semmelweis University, Budapest, Hungary.

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http://dx.doi.org/10.1002/elps.201300515DOI Listing
October 2014

Cytokine-induced iNOS and ERK1/2 inhibit adenylyl cyclase type 5/6 activity and stimulate phosphodiesterase 4D5 activity in intestinal longitudinal smooth muscle.

Am J Physiol Cell Physiol 2014 Aug 18;307(4):C402-11. Epub 2014 Jun 18.

Department of Physiology and Biophysics, Virginia Commonwealth University Program in Enteric Neuromuscular Sciences, Virginia Commonwealth University, Richmond, Virginia; and

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http://dx.doi.org/10.1152/ajpcell.00123.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137135PMC
August 2014

RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection.

Proc Natl Acad Sci U S A 2014 Aug 21;111(31):11461-6. Epub 2014 Jul 21.

Department of Neuroscience, Center for Neurovirology and The Comprehensive NeuroAIDS Center, Temple University School of Medicine, Philadelphia, PA 19140;

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http://dx.doi.org/10.1073/pnas.1405186111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128125PMC
August 2014

Palladium-catalyzed remote C(sp3)-H arylation of 3-pinanamine.

Org Lett 2014 Aug 4;16(16):4288-91. Epub 2014 Aug 4.

School of Pharmaceutical Sciences, Sun Yat-sen University , Guangzhou 510006, China.

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http://dx.doi.org/10.1021/ol502011kDOI Listing
August 2014

Mouse enteric neuronal cell culture.

Methods Mol Biol 2013 ;1078:55-63

Department of Neuroscience, Temple University School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1007/978-1-62703-640-5_6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603984PMC
March 2014

Highly potent dipeptidyl peptidase IV inhibitors derived from Alogliptin through pharmacophore hybridization and lead optimization.

Eur J Med Chem 2013 Oct 13;68:312-20. Epub 2013 Aug 13.

First Affiliated Hospital of Guangzhou Medical University, 151 Yanjiang Road, Guangzhou 510120, China.

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http://dx.doi.org/10.1016/j.ejmech.2013.08.010DOI Listing
October 2013

Novel functions of GABA signaling in adult neurogenesis.

Front Biol (Beijing) 2013 Oct;8(5)

Department of Neuroscience, Temple University School of Medicine, Philadelphia, PA 19140, USA ; Universidade do Estado do Pará, Santarém, PA, Brasil.

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http://dx.doi.org/10.1007/s11515-013-1270-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839947PMC
October 2013

Anti-neuroinflammatory agents for the treatment of Alzheimer's disease.

Authors:
Wei Zhou Wenhui Hu

Future Med Chem 2013 Sep;5(13):1559-71

Guangzhou Institutes of Biomedicine & Health, Chinese Academy of Sciences, Guangzhou 510530, People's Republic of China.

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http://dx.doi.org/10.4155/fmc.13.125DOI Listing
September 2013

Discovery of potent dipeptidyl peptidase IV inhibitors through pharmacophore hybridization and hit-to-lead optimization.

Bioorg Med Chem 2013 Apr 8;21(7):1749-55. Epub 2013 Feb 8.

Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Science, 190 Kaiyuan Avenue, Guangzhou Science Park, Guangzhou 510530, China.

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http://dx.doi.org/10.1016/j.bmc.2013.01.062DOI Listing
April 2013

Design and synthesis of pinanamine derivatives as anti-influenza A M2 ion channel inhibitors.

Antiviral Res 2012 Nov 13;96(2):91-9. Epub 2012 Sep 13.

Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, People's Republic of China.

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http://dx.doi.org/10.1016/j.antiviral.2012.09.001DOI Listing
November 2012

Identification of aminopyridazine-derived antineuroinflammatory agents effective in an Alzheimer's mouse model.

ACS Med Chem Lett 2012 Nov 4;3(11):903-7. Epub 2012 Sep 4.

Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , Guangzhou 510530, People's Republic of China ; State Key Laboratory of Respiratory Disease , Guangzhou 510120, People's Republic of China.

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http://dx.doi.org/10.1021/ml3001769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025747PMC
November 2012

MEKK1-MKK4-JNK-AP1 pathway negatively regulates Rgs4 expression in colonic smooth muscle cells.

PLoS One 2012 24;7(4):e35646. Epub 2012 Apr 24.

Department of Neuroscience, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0035646PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335800PMC
August 2012

NFκB signaling regulates embryonic and adult neurogenesis.

Front Biol (Beijing) 2012 Aug;7(4)

Department of Neuroscience, Temple University School of Medicine, Philadelphia, PA 19140, USA.

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http://dx.doi.org/10.1007/s11515-012-1233-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855406PMC
August 2012

Novel pyrrolopyrimidine analogues as potent dipeptidyl peptidase IV inhibitors based on pharmacokinetic property-driven optimization.

Eur J Med Chem 2012 Jun 17;52:205-12. Epub 2012 Mar 17.

Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kai Yuan Avenue, Guangzhou Science Park, Guangzhou 510530, China.

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http://dx.doi.org/10.1016/j.ejmech.2012.03.015DOI Listing
June 2012

Nuclear factor kappa B signaling initiates early differentiation of neural stem cells.

Stem Cells 2012 Mar;30(3):510-24

Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, People's Republic of China.

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http://dx.doi.org/10.1002/stem.1006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707487PMC
March 2012

Organocatalytic asymmetric domino aza-Michael-Mannich reaction: synthesis of tetrahydroimidazopyrimidine derivatives.

J Org Chem 2011 Oct 25;76(19):8064-9. Epub 2011 Aug 25.

Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Science Park, Guangdong 510530, People's Republic of China.

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http://dx.doi.org/10.1021/jo201301pDOI Listing
October 2011

Sustained survival and maturation of adult neural stem/progenitor cells after transplantation into the injured brain.

J Neurotrauma 2011 Jun 5;28(6):961-72. Epub 2011 May 5.

Department of Neurosurgery, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298-0631, USA.

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http://dx.doi.org/10.1089/neu.2010.1697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113420PMC
June 2011

Discovery of highly potent agents against influenza A virus.

Eur J Med Chem 2011 Jan 16;46(1):52-7. Epub 2010 Oct 16.

Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, 190 Kai Yuan Avenue, Guangzhou Science Park, Guangzhou 510530, People's Republic of China.

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http://dx.doi.org/10.1016/j.ejmech.2010.10.010DOI Listing
January 2011

The highly potent and selective dipeptidyl peptidase IV inhibitors bearing a thienopyrimidine scaffold effectively treat type 2 diabetes.

Eur J Med Chem 2011 Jan 26;46(1):71-6. Epub 2010 Oct 26.

Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kai Yuan Avenue, Guangzhou Science Park, Guangzhou 510530, China.

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http://dx.doi.org/10.1016/j.ejmech.2010.10.016DOI Listing
January 2011

Phenylbutyric acid suppresses protein accumulation-mediated ER stress in retrovirus-infected astrocytes and delays onset of paralysis in infected mice.

Neurochem Int 2010 Dec 8;57(7):738-48. Epub 2010 Sep 8.

Department of Carcinogenesis, The University of Texas, MD Anderson Cancer Center, Science Park-Research Division, Smithville, TX 78957, USA.

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http://dx.doi.org/10.1016/j.neuint.2010.08.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402222PMC
December 2010

RNA-binding protein HuR regulates RGS4 mRNA stability in rabbit colonic smooth muscle cells.

Am J Physiol Cell Physiol 2010 Dec 29;299(6):C1418-29. Epub 2010 Sep 29.

Department of Neuroscience, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.

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http://www.physiology.org/doi/10.1152/ajpcell.00093.2010
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http://dx.doi.org/10.1152/ajpcell.00093.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3006324PMC
December 2010

Identification of hits as matrix-2 protein inhibitors through the focused screening of a small primary amine library.

J Med Chem 2010 May;53(9):3831-4

Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Science Park, Guangdong 510530, People's Republic of China.

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http://dx.doi.org/10.1021/jm901664aDOI Listing
May 2010

Cloning and characterization of rabbit Rgs4 promoter in gut smooth muscle.

Gene 2010 Feb 26;451(1-2):45-53. Epub 2009 Nov 26.

Department of Neuroscience, Temple University School of Medicine, 3500 N Broad Street, Philadelphia, PA 19140, USA.

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http://dx.doi.org/10.1016/j.gene.2009.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690795PMC
February 2010

Molecular properties and CYP2D6 substrates: central nervous system therapeutics case study and pattern analysis of a substrate database.

Drug Metab Dispos 2009 Nov 6;37(11):2204-11. Epub 2009 Aug 6.

Center for Drug Discovery and Chemical Biology, Northwestern University, Chicago, Illinois, USA.

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http://dx.doi.org/10.1124/dmd.109.028134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774985PMC
November 2009

Upregulation of RGS4 expression by IL-1beta in colonic smooth muscle is enhanced by ERK1/2 and p38 MAPK and inhibited by the PI3K/Akt/GSK3beta pathway.

Am J Physiol Cell Physiol 2009 Jun 15;296(6):C1310-20. Epub 2009 Apr 15.

Department of Physiology and Biophysics, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia, USA.

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http://dx.doi.org/10.1152/ajpcell.00573.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692422PMC
June 2009

Interleukin-1beta up-regulates RGS4 through the canonical IKK2/IkappaBalpha/NF-kappaB pathway in rabbit colonic smooth muscle.

Biochem J 2008 May;412(1):35-43

Departments of Physiology and Medicine, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA.

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http://dx.doi.org/10.1042/BJ20080042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707494PMC
May 2008

Upregulation of RGS4 and downregulation of CPI-17 mediate inhibition of colonic muscle contraction by interleukin-1beta.

Am J Physiol Cell Physiol 2007 Dec 24;293(6):C1991-2000. Epub 2007 Oct 24.

Department of Physiology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA.

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http://dx.doi.org/10.1152/ajpcell.00300.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123227PMC
December 2007

HIV protease inhibitors increase TNF-alpha and IL-6 expression in macrophages: involvement of the RNA-binding protein HuR.

Atherosclerosis 2007 Nov 24;195(1):e134-43. Epub 2007 May 24.

Department of Microbiology & Immunology, Virginia Commonwealth University, Richmond, VA 23298, United States.

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http://linkinghub.elsevier.com/retrieve/pii/S002191500700245
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http://dx.doi.org/10.1016/j.atherosclerosis.2007.04.008DOI Listing
November 2007

Characterization of S1P1 and S1P2 receptor function in smooth muscle by receptor silencing and receptor protection.

Am J Physiol Gastrointest Liver Physiol 2006 Oct 4;291(4):G605-10. Epub 2006 May 4.

Dept. of Physiology, P.O. Box 980551, Medical College of Virginia Campus, Virginia Commonwealth Univ., Richmond, VA 23298, USA.

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http://dx.doi.org/10.1152/ajpgi.00147.2006DOI Listing
October 2006

Gi-coupled receptors mediate phosphorylation of CPI-17 and MLC20 via preferential activation of the PI3K/ILK pathway.

Biochem J 2006 May;396(1):193-200

Department of Medicine, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA.

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http://dx.doi.org/10.1042/BJ20051772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1450000PMC
May 2006

Lentiviral siRNA silencing of sphingosine-1-phosphate receptors S1P1 and S1P2 in smooth muscle.

Biochem Biophys Res Commun 2006 May 22;343(4):1038-44. Epub 2006 Mar 22.

Department of Physiology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA.

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http://dx.doi.org/10.1016/j.bbrc.2006.03.079DOI Listing
May 2006

Aminopyridazines attenuate hippocampus-dependent behavioral deficits induced by human beta-amyloid in a murine model of neuroinflammation.

J Mol Neurosci 2004 ;24(1):115-22

Drug Discovery Program, Department of Cell and Molecular Biology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

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http://link.springer.com/10.1385/JMN:24:1:115
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http://dx.doi.org/10.1385/JMN:24:1:115DOI Listing
December 2004

Discovery of 2-phenyl-3-sulfonylphenyl-indole derivatives as a new class of selective COX-2 inhibitors.

Bioorg Med Chem 2003 Dec;11(24):5539-44

Department of Synthetic Medicinal Chemistry, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, PR China.

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http://dx.doi.org/10.1016/j.bmc.2003.09.008DOI Listing
December 2003

Synthesis and biological evaluation of substituted 2-sulfonyl-phenyl-3-phenyl-indoles: a new series of selective COX-2 inhibitors.

Bioorg Med Chem 2003 Apr;11(7):1153-60

Department of Synthetic Medicinal Chemistry, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.

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http://dx.doi.org/10.1016/s0968-0896(03)00046-4DOI Listing
April 2003