Publications by authors named "Wenhua Wang"

179 Publications

Inhalable Biomimetic Protein Corona-Mediated Nanoreactor for Self-Amplified Lung Adenocarcinoma Ferroptosis Therapy.

ACS Nano 2022 May 15. Epub 2022 May 15.

School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, Guangdong, China.

Ferroptosis therapy by catalyzing the Fenton reaction has emerged as a promising tumor elimination strategy for lung adenocarcinoma (ADC). However, the unsatisfactory Fenton reaction efficiency, strong intracellular antioxidant system, and insufficient lung drug accumulation limits the ferroptosis therapeutic effect. To address these issues, an inhalable nanoreactor was proposed by spontaneously adsorbing biomimetic protein corona (PC) composed of matrix metalloproteinase 2 responsive gelatin and glutamate (Glu) on the surface of cationic nanostructured lipid carriers (NLC) core loaded with ferrocene (Fc) and fluvastatin. The prepared Fc-NLC(F)@PC could be nebulized into lung lesions with 2.6 times higher drug accumulation and boost lipid peroxide production by 3.2 times to enhance ferroptosis therapy. Mechanically, fluvastatin was proved to inhibit monocarboxylic acid transporter 4 mediated lactate efflux, inducing tumor acidosis to boost Fc-catalyzing reactive oxygen species production, while the extracellular elevating Glu concentration was found to inhibit xCT (system X) functions and further collapse the tumor antioxidant system by glutathione synthesis suppression. Mitochondrial dysfunction and cell membrane damage were involved in the nanoreactor-driven ferroptotic cell death process. The enhanced antitumor effects by combination of tumor acidosis and antioxidant system collapse were confirmed in an orthotopic lung ADC tumor model. Overall, the proposed nanoreactor highlights the pulmonary delivery approach for local lung ADC treatment and underscores the great potential of ferroptosis therapy.
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http://dx.doi.org/10.1021/acsnano.2c02634DOI Listing
May 2022

Association of ABO blood group with respiratory diseases hospitalisation and severe outcomes: a retrospective cohort study in blood donors.

Int J Infect Dis 2022 May 10. Epub 2022 May 10.

Department of Transfusion Medicine, Shaanxi Provincial People's Hospital, Xi'an, China. Electronic address:

Objectives: Environmental, socioeconomic and genetic factors all are associated with respiratory diseases. We aim to investigate the association between the ABO blood groups and the susceptibility to respiratory diseases.

Methods: We constructed a retrospective cohort study of blood donors in Shaanxi, China between January 1, 2012, and December 31, 2018, to investigate the impacts of the ABO blood group on the risk of hospitalisation due to respiratory diseases.

Results: Of 1,686,263 enrolled participants (680,788 females), 26,597 were admitted to hospital for respiratory diseases. Compared with blood group O, blood groups A, B and AB all demonstrated a higher risk of diseases of the upper respiratory tract (ICD10: J30-J39) (ARR 1.139 95% CI [1.106-1.225]; 1.095 [1.019-1.177]; 1.178 [1.067-1.30], respectively). Conversely, blood group A was found to have a lower risk (0.86 [0.747-0.991]) in influenza (J09-J11) and blood group B was lower for pneumonia (J12-J18) (0.911 [0.851-0.976]) when compared with blood group O. The duration of hospitalisation was significantly different across the blood groups in J09-J11 and J30-J39 (P<0.05).

Conclusions: The blood group appears to be a prognostic factor in differentiating the occurrence of specific respiratory diseases and duration.
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http://dx.doi.org/10.1016/j.ijid.2022.05.019DOI Listing
May 2022

Pulmonary delivery nanomedicines towards circumventing physiological barriers: Strategies and characterization approaches.

Adv Drug Deliv Rev 2022 06 22;185:114309. Epub 2022 Apr 22.

School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, Guangdong, PR China. Electronic address:

Pulmonary delivery of nanomedicines is very promising in lung local disease treatments whereas several physiological barriers limit its application via the interaction with inhaled nanomedicines, namely bio-nano interactions. These bio-nano interactions may affect the pulmonary fate of nanomedicines and impede the distribution of nanomedicines in its targeted region, and subsequently undermine the therapeutic efficacy. Pulmonary diseases are under worse scenarios as the altered physiological barriers generally induce stronger bio-nano interactions. To mitigate the bio-nano interactions and regulate the pulmonary fate of nanomedicines, a number of manipulating strategies were established based on size control, surface modification, charge tuning and co-delivery of mucolytic agents. Visualized and non-visualized characterizations can be employed to validate the robustness of the proposed strategies. This review provides a guiding overview of the physiological barriers affecting the in vivo fate of inhaled nanomedicines, the manipulating strategies, and the validation methods, which will assist with the rational design and application of pulmonary nanomedicine.
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http://dx.doi.org/10.1016/j.addr.2022.114309DOI Listing
June 2022

NLRP3 inflammasome contributes to endotoxin-induced coagulation.

Thromb Res 2022 Jun 8;214:8-15. Epub 2022 Apr 8.

Department of Hematology and Critical Care Medicine, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address:

Introduction: Excessive activation of the coagulation cascades leads to life-threatening disseminated intravascular coagulation (DIC) in sepsis. Two recent studies by our group and others have both demonstrated the noncanonical inflammasome is pivotal for the endotoxin or gram-negative bacterial-induced coagulation. Based on this, we further evaluated the function of the NLRP3 inflammasome, the most studied inflammasome, in endotoxin-induced coagulation.

Materials And Methods: We established an endotoxin-induced coagulation model by intraperitoneal injection of sublethal doses of LPS in mice. Mice were sacrificed 8 h after injection and blood was collected for thrombin-antithrombin (TAT), plasminogen activator inhibitor-1 (PAI-1), prothrombin time (PT), D-dimer, IL-1β and tissue factor (TF) measurements by commercial ELISA. Lungs and livers were examined via HE staining images to determine injury scores and immunohistochemistry for TF expression and fibrin deposits. The role of NLRP3 activation was evaluated in wild-type (WT), Nlrp3, Asc (apoptosis-associated speck-like protein containing a CARD), Caspase-11 mice and 30 min after treatment with MCC950, a potent inhibitor of NLRP3. Western blotting and Q-PCR were performed to assess TF expression in the lungs and livers. To uncover the different effects of NLRP3 and Caspase-11, we also compared the time-dependent IL-1β release in LPS-treated Nlrp3 and Caspase-11 mice. Correlation analysis of TAT, PAI-1 were estimated the relationship of coagulation and release of IL-1β, as well as IL-1β and TF.

Results: Inhibition of NLRP3 by MCC950 as well as NLRP3 or ASC deficiency decreased TAT, PAI-1, PT, D-dimer, and TF levels in blood and impaired the thrombus formation and fibrin deposition, as well as declined expression of TF in the liver and lung in endotoxin-induced coagulation but not caspase-11 deficiency. Impressively, IL-1β release is increased in LPS-treated Caspase-11 mice, but not in Nlrp3 mice. Moreover, the correlation analysis is indicated that downstream of the NLRP3 inflammasome, IL-1β expression, is positively correlated with TAT, PAI-1 and TF in blood circulation.

Conclusions: The NLRP3 inflammasome contributes to endotoxin-induced coagulation by promoting TF expression at least in part through the induction of IL-1β release. These findings broadened our understanding of the mechanism of coagulation and implicated a possible therapeutic strategy for preventing coagulation in sepsis.
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http://dx.doi.org/10.1016/j.thromres.2022.04.001DOI Listing
June 2022

Fabry-Perot Interference Fiber Acoustic Wave Sensor Based on Laser Welding All-Silica Glass.

Authors:
Wenhua Wang

Materials (Basel) 2022 Mar 28;15(7). Epub 2022 Mar 28.

School of Electronic and Information Engineering, Guangdong Ocean University, Zhanjiang 524088, China.

Due to the small difference between the thermal expansion coefficients of silica optical fiber and silica glass, they are used as probe materials of optical fiber acoustic wave sensors. According to the light absorption characteristics of a pressure-sensitive silica diaphragm and silica glass, the laser welding of an all-silica Fabry-Perot (FP) interference optical fiber acoustic wave sensor with a CO laser is proposed. For understanding the influence of thermal expansion of sealing air in an FP cavity and the drift of interference-intensity demodulation working point of a FP interference acoustic wave sensor, we designed a process for the laser welding of an ultra-thin silica diaphragm and sleeve and optical fiber and sleeve. The exhaust hole of the FP cavity is reserved in the preparation process, and an amplified spontaneous emission light source and a tunable optical-fiber FP filter are introduced to stabilize the working point. The sensor is tested with a 40 kHz sound vibration signal. The results show that the sound pressure sensitivity of the sensor to an acoustic source of 0.02-0.1 W/cm is 6.59 mV/kPa. The linearity coefficient is 0.99975, indicating good linearity.
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http://dx.doi.org/10.3390/ma15072484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999880PMC
March 2022

Microvascular Decompression for Trigeminal Neuralgia Caused by Venous Offending on the Ventral Side of the Root Entrance/Exit Zone: Classification and Management Strategy.

Front Neurol 2022 25;13:864061. Epub 2022 Mar 25.

Department of Neurosurgery, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.

Background: Trigeminal neuralgia (TGN) is typically caused by an offending artery (OA) but may also involve an offending vein. Venous offending on the ventral side of the root entrance/exit zone (VO-VREZ) is particularly challenging.

Objective: To analyze the rate and pattern of VO-VREZ and propose management strategy accordingly.

Methods: VO-VREZ was classified into 3 types based on its anatomical relationship with a nerve root (A, the vein was covered by the nerve root entirely; B, the vein was lateral to the nerve root; and C, the vein penetrated the nerve root) and 3 groups based on the absence/presence of offending artery (I, no OA; II, suspected OA; and III, definitive OA).

Results: The analysis included 143 cases with complete follow-up. Type A, B, and C accounted for 11.9, 31.5, and 56.6% of the cases, respectively. Group I, II, and III accounted for 24.5, 26.6, and 49.0%, respectively. Most group I VO-VREZ cases (26 out of 31) were managed with coagulation followed by division. Most group II VO-VREZ cases (31 out of 38) were decompressed with shredded Teflon interposition. Group III VO-VREZ was left in place in all 70 cases. Immediate pain relief was achieved in all cases. Temporary hemifacial hypesthesia occurred in 21 patients (14.7%), among which 14 were managed with Teflon decompression. Within the 4.5-year median follow-up, pain recurred in 11 patients (7.7%), but all with lesser intensity.

Conclusion: VO-VREZ is not uncommon in patients with TGN. Different management strategy should be chosen according to the anatomical feature and the absence/presence of arterial conflict.
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http://dx.doi.org/10.3389/fneur.2022.864061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8990805PMC
March 2022

FTX Attenuates Cerebral Ischemia-Reperfusion Injury by Inhibiting Apoptosis and Oxidative Stress via miR-186-5p/MDM4 Pathway.

Neurotox Res 2022 Apr 28;40(2):542-552. Epub 2022 Mar 28.

Department of Anesthesiology, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Tianning District, 29#, Xinglong Alley, Changzhou, Jiangsu, China.

LncRNA five prime to Xist (FTX) has been identified to exert a protective effect in multiple diseases. However, whether and how FTX attenuates cerebral ischemia-reperfusion injury (CI/RI) is still unclear. To simulate CI/RI, an in vitro oxygen-glucose deprivation/reoxygenation (OGD/R) HT22 cell model and an in vivo middle cerebral artery occlusion/reperfusion (MCAO/R) Sprague-Dawley rat model were respectively constructed. In CI/RI plasma samples, OGD/R-challenged HT22 cells, and brain tissues from MCAO/R rats, FTX and mouse double minute 4 (MDM4) expressions were substantially decreased while miR-186-5p abundance was evidently increased. It was also revealed that FTX obviously improved neuronal damage induced by OGD/R through increasing proliferation, reducing apoptosis, and alleviating oxidative stress in OGD/R-challenged HT22 cells. Additionally, FTX positively regulated MDM4 level in OGD/R-treated HT22 cells as a sponge of miR-186-5p. Moreover, miR-186-5p upregulation or MDM4 suppression restored the inhibitory effects of FTX upregulation on OGD/R-triggered neuronal damage in HT22 cells. Therefore, these results suggest that FTX might ameliorate CI/RI by regulating the miR-186-5p/MDM4 pathway, providing a new target for stroke impairment treatment.
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http://dx.doi.org/10.1007/s12640-022-00485-8DOI Listing
April 2022

Superficial Flat-Type Early-Stage Gastric Signet Ring Cell Carcinoma in the Atrophic Background Mucosa: Two Case Reports.

J Gastrointest Cancer 2022 Mar 19. Epub 2022 Mar 19.

Endoscopy Center, Department of Gastroenterology, Shanghai East Hospital, Tongji University School of Medicine, 150 Jimo Road, Shanghai, 200120, China.

Objectives: Gastric signet ring cell carcinoma is a rare and highly malignant adenocarcinoma, which is characterized by early metastasis, rapid progression and poor prognosis. Several studies have shown that early-stage gastric signet ring cell carcinoma may have equal or better prognosis than other types of gastric cancer. However, most of the early-stage lesions are difficult to detect by endoscopy. We aim to illustrate the difficulty of early detection of gastric signet ring cell carcinoma with mucosal atrophy.

Methods: The endoscopic and pathological features of two female cases were analyzed by upper gastrointestinal white light endoscopy combined with narrow-band imaging and endoscopic biopsy.

Results: Two female cases were diagnosed with early-stage gastric signet ring cell carcinoma with atrophic background mucosa occurring in the middle and lower part of the stomach. Both lesions less than 2.0 cm in diameter were surgically removed and identified as intramucosal adenocarcinoma.

Conclusion: We can roughly identify the demarcation of the lesion by combining white light endoscopy and narrow-band imaging, and slightly irregular microsurface and microvascular pattern of the lesion were found via magnifying endoscopic observation, but the demarcation can hardly be accurately identified.
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http://dx.doi.org/10.1007/s12029-022-00812-4DOI Listing
March 2022

Minimally Invasive Surgery in Chronic Subdural Hematoma: Prognosis and Recurrence Factors of 516 Cases in a Single Center.

J Clin Med 2022 Feb 28;11(5). Epub 2022 Feb 28.

Department of Neurosurgery, Northern Jiangsu People's Hospital, Yangzhou 225001, China.

Objective: To investigate the effects of minimally invasive surgery (MIS) using a novel YL-1 puncture needle and summarize the risk factors of recurrence in chronic subdural hematoma (CSDH).

Methods: We performed a retrospective analysis in 516 hospitalized patients with CSDH from January 2013 to December 2018 in Northern Jiangsu People's Hospital. Patients' gender, age, history of trauma, use of anticoagulants, history of disturbed liver or renal function, history of heart disease, history of malignant tumor, history of diabetes, hemodialysis, coagulopathy, alcoholism, imaging indicators, and postoperative application of urokinase or atorvastatin were recorded. Recurrence is defined by imaging examination with or without clinical presentation three months after discharge.

Results: In total, 483 patients (93.60%) benefited from MIS by YL-1 needle. Gender, age, history of head trauma, history of disturbed liver function, history of heart disease, history of malignant tumor, history of diabetes, history of hemodialysis, coagulopathy, alcoholism, hematoma location, hematoma densities, septum formation, maximum thickness, encephalatrophy, and use of atorvastatin and urokinase were shown to be non-significantly associated with postoperative recurrence ( > 0.05). The use of anticoagulants was significantly associated with postoperative recurrence ( 0. 05). Logistic analysis showed that the use of anticoagulants is an independent factor predicting postoperative recurrence ( 0. 05).

Conclusions: The novel YL-1 puncture needle turned out to be a safe and effective minimally invasive surgery, and the use of anticoagulants is an independent risk factor predicting postoperative recurrence in CSDH, which can provide MIS and early therapeutic strategies for neurosurgeons.
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http://dx.doi.org/10.3390/jcm11051321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911056PMC
February 2022

In Situ Transformation of ZIF-8 into Porous Overlayer on Ru/ZnO for Enhanced Hydrogenation Catalysis.

ACS Appl Mater Interfaces 2022 Mar 4;14(10):12295-12303. Epub 2022 Mar 4.

Department College of Chemistry and Chemical Engineering, Yantai University, Yantai 264005, Shandong China.

Supported metal catalysts play a significant role in heterogeneous catalysis in liquid phase reaction systems, but they usually suffer from a stability problem. Encapsulation of active metal species without the compromise of catalytic performance has been considered as an effective strategy. Here, we report an ultrastable Ru-based catalyst with particle size of around 1.1 nm for selective hydrogenation reaction. The highly dispersed Ru species are covered by the in situ formed porous N-C-ZnO overlayer, which is induced through the transforming of ZIF-8 shell that derives from a ZnO substrate. The resulting Ru/[email protected] catalyst can exhibit good stability in the hydrogenation of -chloronitrobenzene after 20 cyclic runs with 100% selectivity toward -chloroaniline. Comparatively, the naked Ru/ZnO catalyst with larger Ru particles shows serious metal leaching issue with inferior stability and poor selectivity. It is revealed that the excellent performance of Ru/[email protected] is attributed to the porous overlayer, which strengthens the bonding of Ru nanoparticles on ZnO.
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http://dx.doi.org/10.1021/acsami.1c25046DOI Listing
March 2022

Evaluation of Orthokeratology Lens Fitting Assisted by Sagittal Height Simulation Software.

Eye Contact Lens 2022 Feb;48(2):78-82

Department of Translational Medicine, National Engineering Research Center for Ophthalmology, Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Objectives: To evaluate a novel sagittal height fitting algorithm for estimation of alignment curve (AC) radius during Euclid orthokeratology lens trial.

Methods: Chinese myopic children were recruited in this study and were randomly divided into two groups. The AC radius of one group was calculated by the novel fitting algorithm. The AC radius of the other group was decided by the optometrist using flat K readings and eccentricity values. The number of lens trials was recorded for each patient, and the consistencies of AC radius between the first trial lenses and the final ordered lenses were tested by Pearson correlations and Bland-Altman plots.

Results: One hundred three adolescent patients (103 eyes) were enrolled, including 57 boys and 46 girls. The numbers of trials for the novel algorithm and traditional method were 1.2±0.4 times versus 1.4±0.5 times, respectively, and the difference between the two methods was significant (t=2.404, P=0.018). The difference of AC value between the first trial lens and the lens to be produced for the novel algorithm and traditional method 0.000±0.020 mm and 0.003±0.028 mm separately. There was no statistical difference between the two methods (t=0.748, P=0.456).

Conclusions: The new sagittal height simulation software can accurately calculate the AC value of the orthokeratology lens suitable for the Chinese patients.
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http://dx.doi.org/10.1097/ICL.0000000000000861DOI Listing
February 2022

Simultaneous determination of aflatoxins, fumonisin B, T-2 and cyclopiazonic acid in agri-products by immunomagnetic solid-phase extraction coupled with UHPLC-MS/MS.

Food Chem 2022 Jun 4;378:132020. Epub 2022 Jan 4.

Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, Wuhan 430062, China; Key Laboratory of Biology and Genetic Improvement of Oil Crops, Ministry of Agriculture and Rural Affairs, Wuhan 430062, China; Key Laboratory of Detection for Mycotoxins, Ministry of Agriculture and Rural Affairs, Wuhan 430062, China; Laboratory of Quality and Safety Risk Assessment for Oilseeds Products (Wuhan), Ministry of Agriculture and Rural Affairs, Wuhan 430062, China; Quality Inspection and Test Center for Oilseeds Products, Ministry of Agriculture and Rural Affairs, Wuhan 430062, China.

In the present study, a rapid and sensitive determination method of seven mycotoxins was developed using immunomagnetic solid-phase extraction (IMPSE) coupled with UHPLC-MS/MS. Monoclonal antibodies were conjugated with CNBr superparamagnetic beads, and the major parameters affecting the IMPSE efficiency were systematically investigated. Under the optimized conditions, the mycotoxins were purified with the IMSPE procedure within 15 min and simultaneously quantified by UHPLC-MS/MS. Good linearities of the analytic method were established with the determination coefficients (R) ranging from 0.9952 to 0.9997. The limit of quantifications were 0.04 µg kg ∼ 0.16 µg kg, which fully satisfied the regulatory maximum levels. The recoveries were 84.5-112.7% with intra-day and inter-day precision less than 15.2%. Finally, the proposed IMSPE-UHPLC-MS/MS was successfully utilized to analyze seven mycotoxins in peanut, maize, and wheat, providing a simple and robust extraction and enrichment procedure of hydrophilic and zwitterionic analytes from complex matrix.
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http://dx.doi.org/10.1016/j.foodchem.2021.132020DOI Listing
June 2022

Widely Targeted Metabolomics Analysis Reveals Great Changes in Nonvolatile Metabolites of Oolong Teas during Long-Term Storage.

Molecules 2021 Nov 30;26(23). Epub 2021 Nov 30.

College of Horticulture, Fujian Agriculture and Forestry University, Fuzhou 350002, China.

As a semifermented tea, oolong is exceedingly popular worldwide for its elegant, flowery aroma and mellow, rich taste. However, recent marketing trends for old oolong teas and their chemical quality largely remain unexplored. In this study, we applied widely targeted metabolomics using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) combined with multivariate analysis to investigate the chemical change of oolong teas in the aging process. With the increasing of store time, most nongalloylated catechins; tannins, including TFs and proanthocyanidins; flavonols and glycosylated flavonols; amino acids and their derivatives; nucleotides and their derivatives; and lots of alkaloids and phospholipids declined, while most fatty acids and organic acids increased, and galloylated catechins, GA, and caffeine were almost stable. The result also suggested that approximately seven years (but not an infinite extension) was a special period for oolong tea storage, which brings about excellent taste.
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http://dx.doi.org/10.3390/molecules26237278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658923PMC
November 2021

Correlation between microbial communities and flavor compounds during the fifth and sixth rounds of sauce-flavor baijiu fermentation.

Food Res Int 2021 12 12;150(Pt A):110741. Epub 2021 Oct 12.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Beijing 100048, China. Electronic address:

Sauce-flavor baijiu is a representative of Chinese traditional fermented baijiu using grains as the raw materials through the co-fermentation of microorganisms. The whole manufacturing process includes 7 times of distillation and generates 7 kinds of base baijius. The final product is a mixture of the 7 kinds of base baijius. Thus the base baijius greatly affect the quality of the final product. The quality of the base baijiu obtained by the sixth distillation is obviously poorer than that of the fifth one. However, the reason is still unclear and limits the quality control of baijiu fermentation. In this study, the flavor substances and microbiota in the up, middle and bottom layers of fermented grains in the fifth and sixth rounds were compared. Some flavor esters showed obviously decreased concentrations in the sixth round, including ethyl benzoneacetic acid, ethyl hexanoic acid, ethyl dodecanoic acid, diethyl butanedioic acid, and ethyl 2-hydroxyl-propanoic acid. Meanwhile, an off-flavor p-cresol was detected in the sixth round. Correlation analysis of flavor chemicals and microbiota indicated that fungi in the fifth round played an important role for ester synthesis. Some bacterial and fungal species were both positively correlated with p-cresol synthesis, and the related p-cresol metabolic pathways were proposed for the first time. These results revealed flavor divergences of fermented grains between the fifth and sixth rounds, and will ultimately help to improve baijiu quality.
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http://dx.doi.org/10.1016/j.foodres.2021.110741DOI Listing
December 2021

Bibliometric landscape of the researches on protein corona of nanoparticles.

Front Mater Sci 2021 18;15(4):477-493. Epub 2021 Nov 18.

College of Pharmacy, Jinan University, Guangzhou, 510006 China.

Unclear biological fate hampers the clinical translation of nanoparticles for biomedical uses. In recent years, it is documented that the formation of protein corona upon nanoparticles is a critical factor leading to the ambiguous biological fate. Efforts have been made to explore the protein corona forming behaviors on nanoparticles, and rearrangement of the relevant studies will help to understand the current trend of such a topic. In this work, the publications about protein corona of nanoparticles in Science Citation Index Expanded database of Web of Science from 2007 to 2020 (1417 in total) were analyzed in detail, and the bibliometrics landscape of them was showcased. The basic bibliometrics characteristics were summarized to provide an overall understanding. Citation analysis was performed to scrutinize the peer interests of these papers. The research hotspots in the field were evaluated, based on which some feasible topics for future studies were proposed. In general, the results demonstrated that protein corona of nanoparticles was a prospective research area, and had attracted global research interests. It was believed that this work could comprehensively highlight the bibliometrics landscape, inspire further exploitation on protein corona of nanoparticles, and ultimately promote the clinical translation of nanoparticles.
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http://dx.doi.org/10.1007/s11706-021-0571-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8606624PMC
November 2021

[Distribution of ABO and Rh blood groups in Shaanxi Province and its formation by population migration].

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2021 Nov;37(11):1015-1021

Department of Transfusion Medicine, Shaanxi Provincial People's Hospital, Xi'an 710068, China. *Corresponding authors, E-mail:

Objective By investigating the distribution of ABO and Rh blood groups in Shaanxi Province, to discuss the influence of regional division and population migration on blood group distribution. Methods The data of 3 691 624 blood donors from 10 cities in Shaanxi province in the past 20 years was collected. According to the geographical characteristics of Shaanxi province, the data was divided into three regions: Northern Shaanxi, Southern Shaanxi, and Guanzhong, to statistically analyse the distribution of ABO and Rh blood groups across different regions. Heat map software was used to present the ABO blood group on Shaanxi map. The temporal and spatial characteristics of ABO blood group distribution during 2008 and 2018 were analysed and compared. Results ABO blood group distribution of Shaanxi people was O>B>A>AB, with a Rh negative ratio of 0.41%. Based on the ABO blood group distribution map of Shaanxi Province, obvious regional differences were found in ABO blood group distribution. The ABO blood group distribution in Guanzhong, Southern Shaanxi and Northern Shaanxi was B>O>A>AB, O>A>B>AB, and O>B>A>AB respectively, with the lowest proportion of type A being 26.12% in Northern Shaanxi, the lowest proportion of type B being 27.48% in Southern Shaanxi, and the highest proportion of type O being 32.60% and 32.10% in Northern Shaanxi and SouthernShaanxi respectively. Compared with 2008, the distribution of ABO blood groups in the three regions of Shaanxi province changed significantly in 2018. Conclusion The distribution of ABO blood group in Shaanxi province is O>B>A>AB in general. However, there are significant differences in blood group distribution among different regions. It was also found that population migration had an impact on blood group distribution from 1998 to 2018.
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November 2021

Nomogram based on autophagy related genes for predicting the survival in melanoma.

BMC Cancer 2021 Nov 22;21(1):1258. Epub 2021 Nov 22.

The Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Background: Autophagy, a highly conserved lysosomal degradation pathway, is associated with the prognosis of melanoma. However, prognostic prediction models based on autophagy related genes (ARGs) have never been recognized in melanoma. In the present study, we aimed to establish a novel nomogram to predict the prognosis of melanoma based on ARGs signature and clinical parameters.

Methods: Data from The Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression (GTEx) databases were extracted to identify the differentially expressed ARGs. Univariate, least absolute shrinkage and selection operator (LASSO) and multivariate analysis were used to select the prognostic ARGs. ARGs signature, age and stage were then enrolled to establish a nomogram to predict the survival probabilities of melanoma. The nomogram was evaluated by concordance index (C-index), receiver operating characteristic (ROC) curve and calibration curve. Decision curve analysis (DCA) was performed to assess the clinical benefits of the nomogram and TNM stage model. The nomogram was validated in GEO cohorts.

Results: Five prognostic ARGs were selected to construct ARGs signature model and validated in the GEO cohort. Kaplan-Meier survival analysis suggested that patients in high-risk group had significantly worse overall survival than those in low-risk group in TCGA cohort (P = 5.859 × 10-9) and GEO cohort (P = 3.075 × 10-9). We then established and validated a novel promising prognostic nomogram through combining ARGs signature and clinical parameters. The C-index of the nomogram was 0.717 in TCGA training cohort and 0.738 in GEO validation cohort. TCGA/GEO-based ROC curve and decision curve analysis (DCA) demonstrated that the nomogram was better than traditional TNM staging system for melanoma prognosis.

Conclusion: We firstly developed and validated an ARGs signature based-nomogram for individualized prognosis prediction in melanoma patients, which could assist with decision making for clinicians.
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http://dx.doi.org/10.1186/s12885-021-08928-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8607622PMC
November 2021

The COVID-19 Pandemic Changes the Nudging Effect of Social Information on Individuals' Blood Donation Intention.

Front Psychol 2021 26;12:736002. Epub 2021 Oct 26.

Department of Economic and Management, Nankai University Binhai College, Tianjin, China.

The positive effect of social information on nudging prosocial behavior is context dependent. Understanding how sensitive intervention outcomes are to changes in the choice context is essential for policy design, especially in times of great uncertainty, such as the current COVID-19 pandemic. The present paper explores the effectiveness of social information in changing voluntary blood donation intention in two contexts: before and after the peak of the COVID-19 pandemic in China. In addition to the dimension of context, information content and its source are also important. Using a survey administered to 1,116 participants, we conducted an intertemporal randomized-controlled experiment to systematically analyze how information can effectively nudge the intention to donate blood. Compared with content featuring blood donors' commendation information, blood users' demand information is found to have a stronger nudging effect. An official information source has a greater influence on participants' donation intention than an unofficial source. Furthermore, our analysis of two waves of experimental data (i.e., before and after the peak of the COVID-19 pandemic) shows that the COVID-19 pandemic has further enhanced the nudging effect of blood users' demand information and official information sources. These findings provide a theoretical basis and policy recommendations for relevant institutions to develop effective blood donation campaign strategies.
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http://dx.doi.org/10.3389/fpsyg.2021.736002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576010PMC
October 2021

Eliciting Psychological Ownership of Object by Marking Organizational Name: The Role of Belongingness.

Front Psychol 2021 25;12:699738. Epub 2021 Oct 25.

School of Economics, Institute for Study of Brain-Like Economics, Shandong University, Jinan, China.

Psychological ownership critically entails the need for home (a place in which to dwell or a place of belongingness). However, the question of how an individual's need for belongingness within an organization affects their psychological ownership of organization-linked objects remains unexplored. We first conducted a behavioral study to determine whether psychological ownership of object can be elicited by marking the object with the name of the subjects' organization. The participants in this behavioral study reported a higher level of psychological ownership when objects were marked with their own organization's name (i.e., in-organization objects) compared with objects marked with another organization's name (i.e., out-organization objects). Importantly, this effect was more pronounced among subjects who experienced a stronger sense of organizational belongingness. We subsequently conducted a second study to explore its underlying neural mechanism. Our findings indicated that participants with a higher level of perceived organizational belongingness exhibited a significantly larger amplitude of the P300 component of event-related potential in response to in-organization objects compared with their response to out-organization objects. However, no significant difference in the P300 component was found for participants who lacked a sense of organizational belongingness.
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http://dx.doi.org/10.3389/fpsyg.2021.699738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8574952PMC
October 2021

Inhibition of miR-448-3p Attenuates Cerebral Ischemic Injury by Upregulating Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2).

Neuropsychiatr Dis Treat 2021 19;17:3147-3158. Epub 2021 Oct 19.

Department of Neurosurgery, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, 215300, Jiangsu Province, People's Republic of China.

Background: Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key regulator responsible for oxidative stress in brain injury. This study aimed to investigate the potential mechanism of miR-448-3p and Nrf2 in cerebral ischemia/reperfusion (I/R) injury.

Methods: In vitro and in vivo cerebral I/R injury models were constructed, and Nrf2 expression levels were detected by qRT-PCR and Western blot. The potential miRNAs for Nrf2 were predicted by bioinformatic analysis. The binding interaction between miR-448-3p and Nrf2 was determined by luciferase reporter assay. The effects of miR-448-3p on neurological deficit, infarct volume, and brain water content in mice were tested. The effects of miR-448-3p on oxidative stress indicators (SOD activity, MDA content, and ROS production) were detected by commercial assay kits. The levels of HO-1 and cleaved caspase-3 were evaluated by Western blot. Cell viability was evaluated by MTT assay, and cell apoptosis was evaluated by TUNEL staining and flow cytometry.

Results: Nrf2 was significantly downregulated and miR-448-3p was upregulated in cerebral I/R injury both in vivo and in vitro. MiR-448-3p downregulation efficiently attenuated brain injury and reduced oxidative stress and apoptosis. MiR-448-3p was identified to act as ceRNA of Nrf2 and negatively regulated Nrf2 expression, which was consistent with the animal studies. In addition, Nrf2 silencing obviously attenuated the neuroprotective effects of miR-448-3p inhibitor in vitro.

Conclusion: MiR-448-3p participated in the regulation of cerebral I/R injury via inhibiting Nrf2.
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http://dx.doi.org/10.2147/NDT.S310495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541769PMC
October 2021

Major difference in particle size, minor difference in release profile: a case study of solid lipid nanoparticles.

Pharm Dev Technol 2021 Dec 7;26(10):1110-1119. Epub 2021 Nov 7.

College of Pharmacy, Jinan University, Guangzhou, China.

Solid lipid nanoparticles (SLN) have been widely used in a variety of drug delivery routes, which have the outstanding advantage of controlled drug release. The release of SLN is dominated by many factors, among which the particle size of SLN is a critical one. The aim of this project was to explore the relationship between drug release profile and particle size of SLN. SLN were synthesized the hot high-pressure homogenization (HPH) method, budesonide (BUD) was used as the model drug, and BUD-SLN1-BUD-SLN4 with increasing particle size was obtained, i.e. 120, 240, 360, and 480 nm. The prepared SLN has good encapsulation efficiency, drug loading capacity, and stability. release behavior studies showed that the cumulative release of BUD-SLN in Tris-Maleate (Tris-M) media was negligible, while that in Tris-M plus pancreatin media or Tris-M-ethanol media obeyed Ritger-Peppas model or first-order kinetic model, respectively. Noticeably, the release behavior of SLN was to some extent related to the average particle size of SLN, but the correlation was insignificant when the intersection degree of particle size distribution was great. This study provides a new idea for the understanding of release of SLN and has a certain referencing value for the research and development of novel nanomedicines.
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http://dx.doi.org/10.1080/10837450.2021.1998114DOI Listing
December 2021

Alteration of serum neuregulin 4 and neuregulin 1 in gestational diabetes mellitus.

Ther Adv Endocrinol Metab 2021 8;12:20420188211049614. Epub 2021 Oct 8.

Department of Endocrinology and Metabolism, Binzhou Medical University Hospital, Binzhou 256600, Shandong, China.

Context: Neuregulin 4 (Nrg4) and neuregulin 1 (Nrg1) have been shown to play vital roles in several disorders of glucose metabolism. The pathophysiological role of Nrg4 and Nrg1 in gestational diabetes mellitus (GDM), however, remains poorly understood. We assessed the clinical relevance of the two cytokines in patients with GDM.

Methods: The study recruited 36 GDM patients and 38 age-matched, gestational age (24-28 weeks of gestation)-matched, and BMI (during pregnancy)-matched controls in this study. Serum Nrg4 and Nrg1 were measured using ELISA. Inflammatory factors such as IL-6, IL-1β, leptin, TNF-α, and monocyte chemotactic protein 1 (MCP-1) were determined Luminex technique.

Results: Serum Nrg4 in GDM patients was significantly lower than that in the controls, while Nrg1 was significantly higher in the GDM group ( < 0.01). Inflammatory factors such as IL-6, leptin, and TNF-α were significantly increased in GDM patients, while MCP-1 and IL-1β were not significantly different between the two groups. In addition, serum Nrg4 was negatively correlated with fasting glucose (= -0.438,  = 0.008), HOMA-IR (= -0.364,  = 0.029), IL-6 (= -0.384,  = 0.021), leptin (= -0.393,  = 0.018), TNF-α (= -0.346,  = 0.039), and MCP-1 (= -0.342,  = 0.041), and positively correlated with high-density lipoprotein cholesterol (HDL-C) (= -0.357,  = 0.033) in GDM group. Serum Nrg1 was positively correlated with BMI ( = 0.452,  = 0.006), fasting glucose ( = 0.424,  = 0.010), HOMA-IR ( = 0.369,  = 0.027), and triglyceride ( = 0.439,  = 0.007). The decrease of Nrg4 and the increase of Nrg1 were significantly related to the increased prevalence of GDM. Finally, ROC curve results indicated that Nrg1 combined with IL-6 and TNF-α might be an effective means for GDM screening.

Conclusions: Lower circulating Nrg4 and higher circulating Nrg1 serve risk factors of GDM. Nrg1 combined with IL-6 and TNF-α might be a potential tool for GDM screening.
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http://dx.doi.org/10.1177/20420188211049614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504227PMC
October 2021

Fotemustine-based therapy in combination with rituximab as a first-line induction chemotherapy followed by WBRT for newly diagnosed primary central nervous system lymphoma: a prospective phase II trial.

Cancer Biol Med 2021 Oct 12. Epub 2021 Oct 12.

Cancer Research Institute, Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China.

Objective: This study aimed to evaluate the safety, efficacy, and feasibility of the rituximab, fotemustine, pemetrexed, and dexamethasone (R-FPD) regimen followed by whole-brain radiotherapy (WBRT) for patients with primary central nervous system lymphoma (PCNSL).

Methods: A prospective, single-center phase II clinical trial was conducted. Patients with PCNSL newly diagnosed at the First Affiliated Hospital of Zhengzhou University between July 2018 and July 2020 were studied. The R-FPD regimen consisted of rituximab (375 mg/m i.v. on D0), fotemustine (100 mg/m i.v. on D1), pemetrexed (600 mg/m i.v. on D1), and dexamethasone (40 mg i.v. on D1-5). Patients 60 years or younger who showed a complete response (CR) were treated with 23.4 Gy of WBRT after the end of chemotherapy; those older than 60 years with CR were treated with a wait-and-see approach; and those who did not show CR after the 4th cycle of chemotherapy were given salvage WBRT 30 Gy + local tumor field irradiation up to 45 Gy, regardless of age.

Results: A total of 30 patients were included. After 2 cycles, the objective response rate (ORR) was 96.5% (28/29, 1 CR, 27 PR, 0 SD, and 1 PD). After 4 cycles, the ORR was 73.1% (19/26, 11 CR, 8 PR, 4 SD, and 3 PD). After WBRT, the ORR was 90.9% (10/11, 7 CR, 3 PR, and 1 SD). The grade III and IV toxicity responses were mainly leukopenia (20.0%), thrombocytopenia (23.3%), and anemia (10.0%).

Conclusions: Fotemustine-based therapy in combination with rituximab chemotherapy followed by WBRT can improve outcomes, providing ORR benefits and favorable tolerability in patients newly diagnosed with PCNSL.
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http://dx.doi.org/10.20892/j.issn.2095-3941.2021.0026DOI Listing
October 2021

Mineralogical similarities and differences of dust storm particles at Beijing from deserts in the north and northwest.

Sci Total Environ 2022 Jan 4;803:149980. Epub 2021 Sep 4.

School of Forestry, Jiangxi Agricultural University, Nanchang 330045, China.

Dust storm particles have been one of the important contributors to global aerosol loading, affecting human health and climate system. Beijing, a megapolitan city, experienced two severe dust storms in spring of 2015, with maximum hourly-mean PM mass concentrations exceeding 1000 μg/m. The first dust storm (Dust 1) was from east area of Gobi Desert about 850 km in the north of Beijing and the second (Dust 2) was from west area of Gobi Desert about 1500 km in the northwest of Beijing. Morphologies and elemental compositions of dust particles were identified using high-resolution electron microscopy. The statistical analysis showed that the number fractions of mineral dust particles during the two dust storm episodes were 85.3% and 95.4%, respectively. Clay minerals were the most abundant among mineral particles, with a number fraction larger than 50%, followed by quartz particles (17.3% and 14.8%) and feldspar. Feldspar and carbonate particles accounted for 14.8% and 3.4% of mineral particles in Dust 1, and 9.9% and 13.6% in Dust 2, with the difference due to the different source areas. When the dust storms directly migrated to Beijing, the occurrence of S-containing mineral particles and the relative weight ratio of S in individual mineral particles were extremely low, indicating limited production of sulfate on the dust-storm particles in the atmosphere, regardless of the differences of source areas, migration paths, and mineralogical components. After the peaks of dust storms passed, the occurrence of S on the mineral particles were much higher, although the relative weight ratios of S in the mineral particles was still very small. This result suggests that most of the mineral particles underwent heterogeneous reactions, but the reaction rates were low.
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http://dx.doi.org/10.1016/j.scitotenv.2021.149980DOI Listing
January 2022

Body temperatures of Manis pentadactyla and Manis javanica.

Vet Med Sci 2021 11 20;7(6):2399-2403. Epub 2021 Aug 20.

School of Life Sciences, South China Normal University, Guangzhou, 510631, China.

Body temperature is an important parameter for assessing animal health and physiological function. An iButton thermometer was used to measure the body temperatures of three Chinese pangolins (Manis pentadacyla) and three Sunda pangolins (M. javanica). The body temperature of Chinese pangolins was 33.2 ± 0.95°C (30.6-34.2°C, n = 3) and that of Sunda pangolins was 32.8 ± 0.48°C (31.7-34.2°C, n = 3). The daily variation in body temperature was 1.0-2.9°C in three Chinese pangolins and 1.2-1.9°C in three Sunda pangolins. The body temperature of Sunda pangolins tended to rise at night, with the highest body temperatures occurring mostly at night. This study provides valuable body temperature data for Chinese and Sunda pangolins and lays the foundation for future research on their mechanisms of body temperature regulation.
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http://dx.doi.org/10.1002/vms3.611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604104PMC
November 2021

[Analysis of platelet antibody screening in 38 840 inpatients].

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2021 Aug;37(8):736-740

Department of Blood Transfusion, Shaanxi Provincial People's Hospital, Xi'an 710068, China. *Corresponding authors, E-mail:

Objective To detect and analyze the distribution characteristics of platelet antibodies in inpatients and explore the causes of platelet antibodies, so as to provide data support for improving the quality of blood transfusion. Methods A total of 38 840 patients were selected. The platelet-related antibodies were detected by Capture-P solid-phase detection system, and the positive rate of antibodies was analyzed statistically. Results Of the 38840 inpatients, 3989 were positive for platelet antibodies, with a positive rate of 10.27%. The positive rates of male and female patients were 8.7% and 11.5%, respectively. The positive rate of platelet antibodies in patients under 18 years old was 6.98% which was significantly lower than that in patients ≥66 years old and 18~65 years old. The positive rates of patients with pregnancy history and blood transfusion history increased significantly, which were 14.4% and 14.7%, respectively. The positive rate of patients with blood system diseases and liver cirrhosis with gastrointestinal bleeding diseases was over 20%. The positive rates of patients in the Hematology Department, Intensive Care Department and Obstetrics Department ranked the top three, with the positive rates of 15.17%, 14.97%, and 13.67%, respectively. The positive rates of platelet antibodies in patients with blood types B and AB were lower than those in patients with blood types A and O. Conclusion In clinical platelet transfusion, the influence of the patients' age, gender, hospitalized diseases, hospitalized department and other factors on platelet antibodies should be considered to reduce the occurrence of platelet transfusion refractoriness.
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August 2021

The gut microbiome of the Sunda pangolin () reveals its adaptation to specialized myrmecophagy.

PeerJ 2021 2;9:e11490. Epub 2021 Jun 2.

School of Life Science, South China Normal University, Guangzhou, Guangdong Province, China.

Background: The gut microbiomes of mammals are closely related to the diets of their hosts. The Sunda pangolin () is a specialized myrmecophage, but its gut microbiome has rarely been studied.

Methods: Using high-throughput Illumina barcoded 16S rRNA amplicons of nine fecal samples from nine captive Sunda pangolins, we investigated their gut microbiomes.

Results: The detected bacteria were classified into 14 phyla, 24 classes, 48 orders, 97 families, and 271 genera. The main bacterial phyla were Firmicutes (73.71%), Proteobacteria (18.42%), Actinobacteria (3.44%), and Bacteroidetes (0.51%). In the PCoA and neighbor-net network (PERMANOVA: pangolins . other diets, weighted UniFrac distance < 0.01, unweighted UniFrac distance < 0.001), the gut microbiomes of the Sunda pangolins were distinct from those of mammals with different diets, but were much closer to other myrmecophages, and to carnivores, while distant from herbivores. We identified some gut microbiomes related to the digestion of chitin, including , , , and species, which confirms that the gut microbiome of pangolins may help them to digest chitin.

Significance: The results will aid studies of extreme dietary adaption and the mechanisms of diet differentiation in mammals, as well as metagenomic studies, captive breeding, and ex situ conservation of pangolins.
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http://dx.doi.org/10.7717/peerj.11490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179220PMC
June 2021

Serum calprotectin as a prognostic predictor in severe traumatic brain injury.

Clin Chim Acta 2021 Sep 6;520:101-107. Epub 2021 Jun 6.

Department of Neurosurgery, Kunshan Hospital of Traditional Chinese Medicine, Kunshan Affiliated Hospital of Nanjing University of Chinese Medicine, Kunshan 215300, Jiangsu Province, China. Electronic address:

Background: Calprotectin plays an important role during inflammation. We intended to explore the prognostic value of serum calprotectin levels in patients with severe traumatic brain injury (sTBI).

Methods: In this prospective cohort study of 149 sTBI patients, we determined the relationship between serum calprotectin levels and 90-day overall survival plus poor outcome (Glasgow outcome scale score of 1-3) after sTBI, and analyzed its associations with Rotterdam computerized tomography (CT) scores, Glasgow coma scale (GCS) scores and two markers of inflammatory reaction including serum C-reactive protein levels and blood leucocyte count.

Results: Serum calprotectin levels were significantly correlated with Rotterdam CT scores, GCS scores, serum C-reactive protein levels and blood leucocyte count. Patients with poor outcome at 90 days displayed higher serum calprotectin levels than the other remainders. Serum calprotectin appeared as an independent predictor for 90-day overall survival and poor outcome. Under receiver operating characteristic curve, serum calprotectin levels exhibited an efficient discrimination capacity for 90-day poor outcome.

Conclusions: Serum calprotectin levels are significantly correlated with inflammation, trauma severity and poor outcome at 90 days in sTBI patients, suggesting that serum calprotectin may be a biomarker for providing complementary prognostic information to identify patients at risk of poor outcome after sTBI.
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http://dx.doi.org/10.1016/j.cca.2021.06.009DOI Listing
September 2021

Refining the Negative Differential Resistance Effect in a TiO-Based Memristor.

J Phys Chem Lett 2021 Jun 2;12(22):5377-5383. Epub 2021 Jun 2.

College of Artificial Intelligence, Faculty of Materials and Energy, Southwest University, Chongqing 400715, China.

The N-type negative difference resistance (NDR) is characterized by the peak/valley voltage (/) and the corresponding current (/). The N-type NDR is observed in the resistive switching (RS) memory device of Ag|TiO|F-doped SnO at room temperature. After the TiO film is equipped with a nanoporous array, the ∼1.2 V gap voltage between and is effectively downscaled to ∼0.5 V, and the gap current of ∼7.23 mA between and is improved to ∼30 mA. It demonstrates that a lower power consumption and faster switching time of the NDR can be obtained in the memristor. Compensations and synergies among the nanoscale conduction filaments (OH, Ag, and V) are responsible for the refining NDR behavior in our devices. This work provides an efficient method to construct a high-performance N-type NDR effect at room temperature and gives a new horizon on the coexistence of this type of NDR effect and RS memory behaviors.
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http://dx.doi.org/10.1021/acs.jpclett.1c01420DOI Listing
June 2021
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