Wenge Zhong

Amgen Discovery Research, Amgen Asia R&D Center, Amgen Biopharmaceutical R&D (Shanghai) Co. Ltd., 13th Floor, Building No. 2, 4560 Jinke Road, Zhangjiang, Shanghai 201210, China.

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January 2020

Fragment-Based Computational Method for Designing GPCR Ligands.

Authors:

Yan Li Yaping Sun Yunpeng Song Dongcheng Dai Zhixiong Zhao Qing Zhang Wenge Zhong Liaoyuan A Hu Yingli Ma Xun Li Renxiao Wang

J Chem Inf Model 2020 Sep 11;60(9):4339-4349. Epub 2019 Nov 11.

State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, People's Republic of China.

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September 2020

Palladium-Promoted DNA-Compatible Heck Reaction.

Authors:

Xuan Wang Hui Sun Jiaxiang Liu Wenge Zhong Mingqiang Zhang Hu Zhou Dongcheng Dai Xiaojie Lu

Org Lett 2019 02 24;21(3):719-723. Epub 2019 Jan 24.

State Key Laboratory of Drug Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 501 Haike Road, Zhang Jiang Hi-Tech Park , Pudong, Shanghai 201203 , P.R. China.

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February 2019

GPCR structure and function relationship: identification of a biased apelin receptor mutant.

Authors:

Ting Ban Xun Li Xiaochuan Ma Hui Yang Yunpeng Song Yaping Sun Michelle Shen Na Li Mei-Yun Zhang Yingli Ma Wenge Zhong Mingqiang Zhang Liaoyuan A Hu

Biochem J 2018 12 6;475(23):3813-3826. Epub 2018 Dec 6.

Amgen Asia R&D Center, Amgen Biopharmaceutical R&D (Shanghai) Co., Ltd, Shanghai 201210, China

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December 2018

Inverse-Electron-Demand Diels-Alder Reactions for the Synthesis of Pyridazines on DNA.

Authors:

Hailong Li Zhen Sun Wenting Wu Xuan Wang Mingqiang Zhang Xiaojie Lu Wenge Zhong Dongcheng Dai

Org Lett 2018 11 26;20(22):7186-7191. Epub 2018 Oct 26.

Department of Discovery Modalities , Amgen Asia R&D Center, Amgen Research , 4560 Jinke Road , Pudong, Shanghai 201210 , P. R. China.

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November 2018

Discovery of TRPM8 Antagonist ( S)-6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine.

J Med Chem 2018 09 10;61(18):8186-8201. Epub 2018 Sep 10.

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September 2018

Ruthenium-Promoted C-H Activation Reactions between DNA-Conjugated Acrylamide and Aromatic Acids.

Authors:

Xuan Wang Hui Sun Jiaxiang Liu Dongcheng Dai Mingqiang Zhang Hu Zhou Wenge Zhong Xiaojie Lu

Org Lett 2018 08 6;20(16):4764-4768. Epub 2018 Aug 6.

State Key Laboratory of Drug Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 501 Haike Road, Zhang Jiang Hi-Tech Park , Pudong, Shanghai 201203 , P. R. China.

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August 2018

Structural Basis for Apelin Control of the Human Apelin Receptor.

Structure 2017 06 18;25(6):858-866.e4. Epub 2017 May 18.

iHuman Institute, ShanghaiTech University, 2F Building 6, 99 Haike Road, Pudong New District, Shanghai 201210, China; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China. Electronic address:

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June 2017

Preclinical Evaluation of AMG 337, a Highly Selective Small Molecule MET Inhibitor, in Hepatocellular Carcinoma.

Authors:

Zhiqiang Du Sean Caenepeel Yuqing Shen Karen Rex Yanni Zhang Ying He En-Tzu Tang Ouhong Wang Wenge Zhong Hui Zhou Jacqueline Huang Eric Huang Liaoyuan Hu Angela Coxon Mingqiang Zhang

Mol Cancer Ther 2016 06 29;15(6):1227-37. Epub 2016 Mar 29.

Amgen Biopharmaceutical Research & Development (Shanghai) Co., Ltd, Shanghai, China.

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June 2016

Development of 2-aminooxazoline 3-azaxanthenes as orally efficacious β-secretase inhibitors for the potential treatment of Alzheimer's disease.

Bioorg Med Chem Lett 2015 Feb 8;25(4):767-74. Epub 2015 Jan 8.

Department of Medicinal Chemistry, Amgen Inc., 360 Binney Street, Cambridge, MA 02142, USA.

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February 2015

Hydroxyethylamine-based inhibitors of BACE1: P₁-P₃ macrocyclization can improve potency, selectivity, and cell activity.

Authors:

Lewis D Pennington Douglas A Whittington Michael D Bartberger Steven R Jordan Holger Monenschein Thomas T Nguyen Bryant H Yang Qiufen M Xue Filisaty Vounatsos Robert C Wahl Kui Chen Stephen Wood Martin Citron Vinod F Patel Stephen A Hitchcock Wenge Zhong

Bioorg Med Chem Lett 2013 Aug 16;23(15):4459-64. Epub 2013 May 16.

Medicinal Chemistry, Amgen, One Amgen Center Drive, Thousand Oaks, CA 91320, USA.

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August 2013

Discovery of selective biaryl ethers as PDE10A inhibitors: improvement in potency and mitigation of Pgp-mediated efflux.

Authors:

Robert M Rzasa Essa Hu Shannon Rumfelt Ning Chen Kristin L Andrews Samer Chmait James R Falsey Wenge Zhong Adrie D Jones Amy Porter Steven W Louie Xiaoning Zhao James J S Treanor Jennifer R Allen

Bioorg Med Chem Lett 2012 Dec 22;22(24):7371-5. Epub 2012 Oct 22.

Department of Medicinal Chemistry, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.

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December 2012

A Potent and Orally Efficacious, Hydroxyethylamine-Based Inhibitor of β-Secretase.

ACS Med Chem Lett 2012 Nov 29;3(11):886-91. Epub 2012 Mar 29.

Chemistry Research and Discovery, Department of Molecular Structure, Department of Neuroscience, Department of HTS and Molecular Pharmacology, and Department of Pharmacokinetics and Drug Metabolism, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States.

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November 2012