Wendy Sandoval

Wendy Sandoval

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Wendy Sandoval

Wendy Sandoval

Publications by authors named "Wendy Sandoval"

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Native Hydrophobic Interaction Chromatography Hyphenated to Mass Spectrometry for Characterization of Monoclonal Antibody Minor Variants.

Anal Chem 2019 Dec 26;91(24):15360-15364. Epub 2019 Nov 26.

Department of Protein Analytical Chemistry , Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.

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http://dx.doi.org/10.1021/acs.analchem.9b04467DOI Listing
December 2019

Elucidating heavy/light chain pairing preferences to facilitate the assembly of bispecific IgG in single cells.

MAbs 2019 Oct 26;11(7):1254-1265. Epub 2019 Jul 26.

Department of Antibody Engineering, Genentech, Inc ., South San Francisco , CA , USA.

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http://dx.doi.org/10.1080/19420862.2019.1640549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748609PMC
October 2019

Charge variant native mass spectrometry benefits mass precision and dynamic range of monoclonal antibody intact mass analysis.

MAbs 2018 Nov-Dec;10(8):1214-1225. Epub 2018 Oct 19.

b Department of Microchemistry, Proteomics and Lipidomics , Genentech, Inc , South San Francisco , CA , USA.

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http://dx.doi.org/10.1080/19420862.2018.1521131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284562PMC
June 2019

Interaction of cell culture process parameters for modulating mAb afucosylation.

Biotechnol Bioeng 2019 04 4;116(4):831-845. Epub 2019 Feb 4.

Cell Culture, PTD, Genentech, South San Francisco, California.

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http://dx.doi.org/10.1002/bit.26908DOI Listing
April 2019

In Vivo Stability Profiles of Anti-factor D Molecules Support Long-Acting Delivery Approaches.

Mol Pharm 2019 01 3;16(1):86-95. Epub 2018 Dec 3.

Department of Protein Chemistry , Genentech, Inc. , South San Francisco , California 94080 , United States.

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http://dx.doi.org/10.1021/acs.molpharmaceut.8b00871DOI Listing
January 2019

Quantitative Determination of Protein-Ligand Affinity by Size Exclusion Chromatography Directly Coupled to High-Resolution Native Mass Spectrometry.

Anal Chem 2019 Jan 12;91(1):903-911. Epub 2018 Dec 12.

Thermo Fisher Scientific , 355 River Oaks Parkway , San Jose , California 95134 , United States.

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http://dx.doi.org/10.1021/acs.analchem.8b03829DOI Listing
January 2019

Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate.

Mol Cell 2018 08;71(4):629-636.e5

Cancer Immunology, Genentech, Inc., South San Francisco, CA 94080, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2018.06.038DOI Listing
August 2018

Comparison of platform host cell protein ELISA to process-specific host cell protein ELISA.

Biotechnol Bioeng 2018 02 30;115(2):382-389. Epub 2017 Oct 30.

CMC Paradigm LLC, San Anselmo, California.

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http://dx.doi.org/10.1002/bit.26466DOI Listing
February 2018

Structural and Functional Characterization of a Hole-Hole Homodimer Variant in a "Knob-Into-Hole" Bispecific Antibody.

Anal Chem 2017 12 1;89(24):13494-13501. Epub 2017 Dec 1.

The Molecular Foundry, Lawrence Berkeley National Laboratory , One Cyclotron Road, Berkeley, California 94720, United States.

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http://pubs.acs.org/doi/10.1021/acs.analchem.7b03830
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http://dx.doi.org/10.1021/acs.analchem.7b03830DOI Listing
December 2017

Expansion of the ISWI chromatin remodeler family with new active complexes.

EMBO Rep 2017 10 11;18(10):1697-1706. Epub 2017 Aug 11.

Department of Early Discovery Biochemistry, Genentech, Inc., South San Francisco, CA, USA

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http://dx.doi.org/10.15252/embr.201744011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623870PMC
October 2017

Preparation and evaluation of L- and D-5-[F]fluorotryptophan as PET imaging probes for indoleamine and tryptophan 2,3-dioxygenases.

Nucl Med Biol 2017 Aug 5;51:10-17. Epub 2017 May 5.

Genentech Research and Early Development, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nucmedbio.2017.05.001DOI Listing
August 2017

De Novo MS/MS Sequencing of Native Human Antibodies.

J Proteome Res 2017 01 2;16(1):45-54. Epub 2016 Nov 2.

Department of Computer Science and Engineering, University of California, San Diego , 9500 Gilman Drive, Mail Code 0404, La Jolla, California 92093, United States.

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http://dx.doi.org/10.1021/acs.jproteome.6b00608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574256PMC
January 2017

Characterization of Chain Pairing Variants of Bispecific IgG Expressed in a Single Host Cell by High-Resolution Native and Denaturing Mass Spectrometry.

Anal Chem 2016 12 8;88(24):12122-12127. Epub 2016 Dec 8.

Departments of Proteomics & Biological Resources, ‡Antibody Engineering, and §Protein Chemistry, Genentech, Inc. , South San Francisco, California 94080, United States.

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http://dx.doi.org/10.1021/acs.analchem.6b02866DOI Listing
December 2016

Proline Starvation Induces Unresolved ER Stress and Hinders mTORC1-Dependent Tumorigenesis.

Cell Metab 2016 11 8;24(5):753-761. Epub 2016 Sep 8.

Department of Discovery Oncology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address:

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http://www.cell.com/cell-metabolism/pdf/S1550-4131(16)30424-
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http://dx.doi.org/10.1016/j.cmet.2016.08.008DOI Listing
November 2016

Expression, purification, and characterization of recombinant human and murine milk fat globule-epidermal growth factor-factor 8.

Protein Expr Purif 2016 08 19;124:10-22. Epub 2016 Apr 19.

Department of Protein Chemistry and Structural Biology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address:

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http://dx.doi.org/10.1016/j.pep.2016.04.006DOI Listing
August 2016

Rapid, semi-automated protein terminal characterization using ISDetect.

Nat Biotechnol 2016 08;34(8):811-3

Department of Protein Chemistry, Genentech, Inc., South San Francisco, California, USA.

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http://dx.doi.org/10.1038/nbt.3621DOI Listing
August 2016

mTORC1-Dependent Metabolic Reprogramming Underlies Escape from Glycolysis Addiction in Cancer Cells.

Cancer Cell 2016 Apr 24;29(4):548-562. Epub 2016 Mar 24.

Department of Discovery Oncology, Genentech Inc, South San Francisco, CA 94080, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.02.018DOI Listing
April 2016

Enhancing full-length antibody production by signal peptide engineering.

Microb Cell Fact 2016 Mar 2;15:47. Epub 2016 Mar 2.

Department of Early Stage Cell Culture, Genentech Inc., 1 DNA way, South San Francisco, CA, 94080, USA.

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http://dx.doi.org/10.1186/s12934-016-0445-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776426PMC
March 2016

Palmitoylation of TEAD Transcription Factors Is Required for Their Stability and Function in Hippo Pathway Signaling.

Structure 2016 Jan 24;24(1):179-186. Epub 2015 Dec 24.

Department of Early Discovery Biochemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address:

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http://dx.doi.org/10.1016/j.str.2015.11.005DOI Listing
January 2016

IgRepertoireConstructor: a novel algorithm for antibody repertoire construction and immunoproteogenomics analysis.

Bioinformatics 2015 Jun;31(12):i53-61

Center for Algorithmic Biotechnology, St. Petersburg State University, St. Petersburg, Russia, Algorithmic Biology Laboratory, St. Petersburg Academic University, St. Petersburg, Russia, Bioinformatics Program, University of California, San Diego, CA, USA, Genentech, South San Francisco, CA, USA and Department of Computer Science and Engineering, University of California, San Diego, CA, USA Center for Algorithmic Biotechnology, St. Petersburg State University, St. Petersburg, Russia, Algorithmic Biology Laboratory, St. Petersburg Academic University, St. Petersburg, Russia, Bioinformatics Program, University of California, San Diego, CA, USA, Genentech, South San Francisco, CA, USA and Department of Computer Science and Engineering, University of California, San Diego, CA, USA Center for Algorithmic Biotechnology, St. Petersburg State University, St. Petersburg, Russia, Algorithmic Biology Laboratory, St. Petersburg Academic University, St. Petersburg, Russia, Bioinformatics Program, University of California, San Diego, CA, USA, Genentech, South San Francisco, CA, USA and Department of Computer Science and Engineering, University of California, San Diego, CA, USA.

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http://dx.doi.org/10.1093/bioinformatics/btv238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542777PMC
June 2015

Host cell protein testing by ELISAs and the use of orthogonal methods.

Biotechnol Bioeng 2014 Dec 10;111(12):2367-79. Epub 2014 Sep 10.

Protein Analytical Chemistry, Genentech, 1 DNA Way, South San Francisco, CA, 94080.

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http://dx.doi.org/10.1002/bit.25327DOI Listing
December 2014

Structure of the BRAF-MEK complex reveals a kinase activity independent role for BRAF in MAPK signaling.

Cancer Cell 2014 Sep 21;26(3):402-413. Epub 2014 Aug 21.

Department of Biochemical and Cellular Pharmacology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.07.007DOI Listing
September 2014

Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Analysis of Peptides.

Authors:
Wendy Sandoval

Curr Protoc Protein Sci 2014 Aug 1;77:16.2.1-16.2.11. Epub 2014 Aug 1.

Department of Protein Chemistry, Genentech, South San Francisco, California.

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http://doi.wiley.com/10.1002/0471140864.ps1602s77
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http://dx.doi.org/10.1002/0471140864.ps1602s77DOI Listing
August 2014

Conformational stabilization of ubiquitin yields potent and selective inhibitors of USP7.

Nat Chem Biol 2013 Jan 25;9(1):51-8. Epub 2012 Nov 25.

Department of Early Discovery Biochemistry, Genentech Inc., San Francisco, California, USA.

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http://www.nature.com/articles/nchembio.1134
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http://dx.doi.org/10.1038/nchembio.1134DOI Listing
January 2013

Structural and functional analysis of HtrA1 and its subdomains.

Structure 2012 Jun 10;20(6):1040-50. Epub 2012 May 10.

Department of Structural Biology, Genentech, Inc., South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1016/j.str.2012.03.021DOI Listing
June 2012

A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain.

Nat Cell Biol 2011 Dec 18;14(1):61-72. Epub 2011 Dec 18.

Department of Molecular Biology, Genentech, South San Francisco, California 94080, USA.

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http://www.nature.com/articles/ncb2410
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http://dx.doi.org/10.1038/ncb2410DOI Listing
December 2011

Preview: a program for surveying shotgun proteomics tandem mass spectrometry data.

Anal Chem 2011 Jul 13;83(13):5259-67. Epub 2011 Jun 13.

Palo Alto Research Center, 3333 Coyote Hill Road, Palo Alto, California 94304, USA.

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http://dx.doi.org/10.1021/ac200609aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3134881PMC
July 2011

Recent developments in microwave-assisted protein chemistries - can this be integrated into the drug discovery and validation process?

Drug Discov Today 2008 Dec 7;13(23-24):1075-81. Epub 2008 Nov 7.

Genentech Inc., Department of Protein Chemistry, 1 DNA Way, MS 413A, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1016/j.drudis.2008.08.007DOI Listing
December 2008

Applications of microwave-assisted proteomics in biotechnology.

Comb Chem High Throughput Screen 2007 Nov;10(9):751-65

Protein Chemistry Department, Genentech Inc., South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.2174/138620707783018504DOI Listing
November 2007

Microwave-assisted proteomics.

Mass Spectrom Rev 2007 Sep-Oct;26(5):657-71

Protein Chemistry Department, Genentech Inc, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1002/mas.20140DOI Listing
October 2007

De novo proteomic sequencing of a monoclonal antibody raised against OX40 ligand.

Anal Biochem 2006 May 21;352(1):77-86. Epub 2006 Feb 21.

Department of Protein Chemistry, Genentech, South San Francisco, CA 94080, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S000326970600088
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http://dx.doi.org/10.1016/j.ab.2006.02.001DOI Listing
May 2006