Publications by authors named "Wendy S Barclay"

82Publications

Host ANP32A mediates the assembly of the influenza virus replicase.

Nature 2020 Nov 18. Epub 2020 Nov 18.

Division of Structural Biology, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/s41586-020-2927-zDOI Listing
November 2020

Quantifying mechanistic traits of influenza viral dynamics using in vitro data.

Epidemics 2020 Oct 3;33:100406. Epub 2020 Oct 3.

MRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London W2 1PG, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.epidem.2020.100406DOI Listing
October 2020

Host Cell Factors That Interact with Influenza Virus Ribonucleoproteins.

Cold Spring Harb Perspect Med 2020 Sep 28. Epub 2020 Sep 28.

Department of Infectious Disease, Faculty of Medicine, Imperial College London, St. Mary's Campus, London W2 1NY, United Kingdom.

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http://dx.doi.org/10.1101/cshperspect.a038307DOI Listing
September 2020

ACE2: The Only Thing That Matters?

Am J Respir Crit Care Med 2020 07;202(2):161-163

Section of Molecular VirologyImperial College LondonLondon, United Kingdom.

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http://dx.doi.org/10.1164/rccm.202006-2151EDDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365380PMC
July 2020

Passage of influenza A/H3N2 viruses in human airway cells removes artefactual variants associated with neuraminidase-mediated binding.

J Gen Virol 2020 05 6;101(5):456-466. Epub 2019 Nov 6.

Present address: WHO Collaborating Centre for Reference and Research on Influenza, Francis Crick Institute, London, UK.

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http://dx.doi.org/10.1099/jgv.0.001348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414449PMC
May 2020

Elucidating the Interactions between Influenza Virus Polymerase and Host Factor ANP32A.

J Virol 2020 01 17;94(3). Epub 2020 Jan 17.

Section of Molecular Virology, Imperial College London, London, United Kingdom

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http://dx.doi.org/10.1128/JVI.01353-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000967PMC
January 2020

Pregnancy-related immune suppression leads to altered influenza vaccine recall responses.

Clin Immunol 2019 11 27;208:108254. Epub 2019 Aug 27.

Department of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital, London SW10 9NH, United Kingdom.

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http://dx.doi.org/10.1016/j.clim.2019.108254DOI Listing
November 2019

Entry of the bat influenza H17N10 virus into mammalian cells is enabled by the MHC class II HLA-DR receptor.

Nat Microbiol 2019 12 29;4(12):2035-2038. Epub 2019 Jul 29.

Viral Pseudotype Unit, Medway School of Pharmacy, University of Kent and University of Greenwich, Chatham, UK.

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http://dx.doi.org/10.1038/s41564-019-0517-3DOI Listing
December 2019

Host Determinants of Influenza RNA Synthesis.

Annu Rev Virol 2019 09 5;6(1):215-233. Epub 2019 Jul 5.

Department of Medicine, Imperial College London, London W2 1PG, United Kingdom; email:

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http://dx.doi.org/10.1146/annurev-virology-092917-043339DOI Listing
September 2019

ANP32 Proteins Are Essential for Influenza Virus Replication in Human Cells.

J Virol 2019 09 13;93(17). Epub 2019 Aug 13.

Section of Molecular Virology, Imperial College London, St Mary's Campus, London, United Kingdom

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http://dx.doi.org/10.1128/JVI.00217-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694824PMC
September 2019

Receptor for bat influenza virus uncovers potential risk to humans.

Authors:
Wendy S Barclay

Nature 2019 03;567(7746):35-36

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http://dx.doi.org/10.1038/d41586-019-00580-5DOI Listing
March 2019

Publisher Correction: Host and viral determinants of influenza A virus species specificity.

Nat Rev Microbiol 2019 Jan;17(2):124

Department of Medicine, Imperial College London, London, UK.

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http://www.nature.com/articles/s41579-018-0140-y
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http://dx.doi.org/10.1038/s41579-018-0140-yDOI Listing
January 2019

Host and viral determinants of influenza A virus species specificity.

Nat Rev Microbiol 2019 01;17(2):67-81

Department of Medicine, Imperial College London, London, UK.

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http://dx.doi.org/10.1038/s41579-018-0115-zDOI Listing
January 2019

The mechanism of resistance to favipiravir in influenza.

Proc Natl Acad Sci U S A 2018 11 23;115(45):11613-11618. Epub 2018 Oct 23.

Section of Molecular Virology, Imperial College London, London W2 1PG, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1811345115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233120PMC
November 2018

Assays to Measure the Activity of Influenza Virus Polymerase.

Methods Mol Biol 2018 ;1836:343-374

Faculty of Medicine, Division of Infectious Disease, Imperial College London, London, UK.

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http://dx.doi.org/10.1007/978-1-4939-8678-1_17DOI Listing
April 2019

Influenza: a world of discoveries, outbreaks and controversy.

Authors:
Wendy S Barclay

J Gen Virol 2017 May 24;98(5):892-894. Epub 2017 May 24.

Imperial College, Norfolk Place, London W2 1PG, UK.

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http://dx.doi.org/10.1099/jgv.0.000812DOI Listing
May 2017

Influenza A virus PB1-F2 protein prolongs viral shedding in chickens lengthening the transmission window.

J Gen Virol 2016 10 23;97(10):2516-2527. Epub 2016 Aug 23.

Avian Viral Diseases Programme, The Pirbright Institute, Pirbright, Surrey, UK.

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http://dx.doi.org/10.1099/jgv.0.000584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078828PMC
October 2016

An engineered avian-origin influenza A virus for pancreatic ductal adenocarcinoma virotherapy.

J Gen Virol 2016 09 14;97(9):2166-2179. Epub 2016 Jul 14.

Imperial College London, Faculty of Medicine, Division of Infectious Disease, 8 Norfolk Place, London W2 1PG, UK.

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https://www.microbiologyresearch.org/content/journal/jgv/10.
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http://dx.doi.org/10.1099/jgv.0.000549DOI Listing
September 2016

NB protein does not affect influenza B virus replication in vitro and is not required for replication in or transmission between ferrets.

J Gen Virol 2016 Mar 24;97(3):593-601. Epub 2015 Dec 24.

Section of Virology, Faculty of Medicine, Wright Fleming Institute, Imperial College London, Norfolk Place, London W2 1PG, UK.

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http://dx.doi.org/10.1099/jgv.0.000386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381391PMC
March 2016

Knowns and unknowns of influenza B viruses.

Future Microbiol 2016 18;11(1):119-35. Epub 2015 Dec 18.

Department of Microbiology & Immunology, University of Melbourne, at the Peter Doherty Institute for Infection & Immunity, Parkville VIC 3010, Australia.

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http://dx.doi.org/10.2217/fmb.15.120DOI Listing
October 2016

The Functional Study of the N-Terminal Region of Influenza B Virus Nucleoprotein.

PLoS One 2015 14;10(9):e0137802. Epub 2015 Sep 14.

Centre for Protein Science and Crystallography, School of Life Sciences, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0137802PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569402PMC
May 2016

Amino acid substitution D222N from fatal influenza infection affects receptor-binding properties of the influenza A(H1N1)pdm09 virus.

Virology 2015 Oct 5;484:15-21. Epub 2015 Jun 5.

Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autonoma de Yucatan, Av. Itzaes #490×59, Centro, C. P., 97000 Merida, Yucatan, Mexico. Electronic address:

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http://dx.doi.org/10.1016/j.virol.2015.05.012DOI Listing
October 2015

Ferret airway epithelial cell cultures support efficient replication of influenza B virus but not mumps virus.

J Gen Virol 2015 Aug 6;96(8):2092-2098. Epub 2015 May 6.

Imperial College London, Faculty of Medicine, Division of Infectious Disease, Norfolk Place, London W2 1PG, UK.

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http://dx.doi.org/10.1099/vir.0.000176DOI Listing
August 2015

One-way trip: influenza virus' adaptation to gallinaceous poultry may limit its pandemic potential.

Bioessays 2015 Feb 28;37(2):204-12. Epub 2014 Dec 28.

Imperial College London, Department of Medicine, Section of Virology, London, UK.

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http://dx.doi.org/10.1002/bies.201400133DOI Listing
February 2015

Glycomic characterization of respiratory tract tissues of ferrets: implications for its use in influenza virus infection studies.

J Biol Chem 2014 Oct 18;289(41):28489-504. Epub 2014 Aug 18.

From the Department of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, United Kingdom,

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http://dx.doi.org/10.1074/jbc.M114.588541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192499PMC
October 2014

Viral determinants of influenza A virus host range.

J Gen Virol 2014 Jun 28;95(Pt 6):1193-1210. Epub 2014 Feb 28.

Imperial College London, Faculty of Medicine, Division of Infectious Disease, Norfolk Place, London W2 1PG, UK.

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http://dx.doi.org/10.1099/vir.0.062836-0DOI Listing
June 2014

The short stalk length of highly pathogenic avian influenza H5N1 virus neuraminidase limits transmission of pandemic H1N1 virus in ferrets.

J Virol 2013 Oct 17;87(19):10539-51. Epub 2013 Jul 17.

Section of Virology, Division of Infectious Disease, Imperial College London, St. Mary's Campus, Norfolk Place, London, United Kingdom.

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http://dx.doi.org/10.1128/JVI.00967-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807409PMC
October 2013

The effect of the PB2 mutation 627K on highly pathogenic H5N1 avian influenza virus is dependent on the virus lineage.

J Virol 2013 Sep 10;87(18):9983-96. Epub 2013 Jul 10.

Section of Virology, Division of Infectious Disease, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1128/JVI.01399-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753988PMC
September 2013

Obesity and susceptibility to severe outcomes following respiratory viral infection.

Thorax 2013 Jul 22;68(7):684-6. Epub 2013 Feb 22.

Airway Disease Infection Section, National Heart and Lung Institute, Imperial College London, UK.

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http://dx.doi.org/10.1136/thoraxjnl-2012-203009DOI Listing
July 2013

Unstable polymerase-nucleoprotein interaction is not responsible for avian influenza virus polymerase restriction in human cells.

J Virol 2013 Jan 31;87(2):1278-84. Epub 2012 Oct 31.

Imperial College London, Faculty of Medicine, Division of Infectious Disease, London, United Kingdom.

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http://dx.doi.org/10.1128/JVI.02597-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554100PMC
January 2013

Investigation of influenza virus polymerase activity in pig cells.

J Virol 2013 Jan 17;87(1):384-94. Epub 2012 Oct 17.

Section of Virology, Department of Medicine, Imperial College London, St. Mary's Campus, London, United Kingdom.

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http://dx.doi.org/10.1128/JVI.01633-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536367PMC
January 2013

Transmission of a 2009 H1N1 pandemic influenza virus occurs before fever is detected, in the ferret model.

PLoS One 2012 29;7(8):e43303. Epub 2012 Aug 29.

Section of Virology, Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0043303PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430703PMC
February 2013

Predominance of heterosubtypic IFN-γ-only-secreting effector memory T cells in pandemic H1N1 naive adults.

Eur J Immunol 2012 Nov 15;42(11):2913-24. Epub 2012 Aug 15.

Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College London, Paddington, London, UK.

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http://dx.doi.org/10.1002/eji.201242504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310933PMC
November 2012

Lack of transmission of a human influenza virus with avian receptor specificity between ferrets is not due to decreased virus shedding but rather a lower infectivity in vivo.

J Gen Virol 2011 Aug 20;92(Pt 8):1822-1831. Epub 2011 Apr 20.

Department of Virology, Division of Infectious Disease, Imperial College London, St Mary's Campus, Norfolk Place, London W2 1PG, UK.

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http://dx.doi.org/10.1099/vir.0.031203-0DOI Listing
August 2011

Influence of PB2 host-range determinants on the intranuclear mobility of the influenza A virus polymerase.

J Gen Virol 2011 Jul 6;92(Pt 7):1650-1661. Epub 2011 Apr 6.

Division of Virology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK.

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http://dx.doi.org/10.1099/vir.0.031492-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167894PMC
July 2011

Pandemic H1N1 2009 influenza virus with the H275Y oseltamivir resistance neuraminidase mutation shows a small compromise in enzyme activity and viral fitness.

J Antimicrob Chemother 2011 Mar 16;66(3):466-70. Epub 2010 Dec 16.

Section of Virology, Faculty of Medicine, Wright Fleming Institute, Imperial College London, Norfolk Place, London W2 1PG, UK.

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http://dx.doi.org/10.1093/jac/dkq486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037153PMC
March 2011

Molecular studies of influenza B virus in the reverse genetics era.

J Gen Virol 2011 Jan 6;92(Pt 1):1-17. Epub 2010 Oct 6.

Centre for Biomolecular Sciences, University of St Andrews, St Andrews, Fife KY16 9ST, UK.

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http://dx.doi.org/10.1099/vir.0.026187-0DOI Listing
January 2011

Evidence for avian and human host cell factors that affect the activity of influenza virus polymerase.

J Virol 2010 Oct 14;84(19):9978-86. Epub 2010 Jul 14.

Department of Virology, Division of Infectious Diseases, Imperial College London, Wright Fleming Institute, Norfolk Place, W2 1PG London, UK.

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http://dx.doi.org/10.1128/JVI.01134-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937815PMC
October 2010

Avian Influenza virus glycoproteins restrict virus replication and spread through human airway epithelium at temperatures of the proximal airways.

PLoS Pathog 2009 May 15;5(5):e1000424. Epub 2009 May 15.

Cystic Fibrosis/Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1371/journal.ppat.1000424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673688PMC
May 2009

Structure of an avian influenza A virus NS1 protein effector domain.

Virology 2008 Aug 27;378(1):1-5. Epub 2008 Jun 27.

Centre for Biomolecular Sciences, University of St. Andrews, St. Andrews, Fife, KY16 9ST, UK.

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http://dx.doi.org/10.1016/j.virol.2008.05.026DOI Listing
August 2008

Alterations in receptor binding properties of recent human influenza H3N2 viruses are associated with reduced natural killer cell lysis of infected cells.

J Virol 2007 Oct 1;81(20):11170-8. Epub 2007 Aug 1.

Imperial College London, Department of Virology, Division of Investigative Science, Faculty of Medicine, St. Mary's Campus, Norfolk Place, London W2 1PG, United Kingdom.

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http://dx.doi.org/10.1128/JVI.01217-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2045558PMC
October 2007

Probing the receptor interactions of an H5 avian influenza virus using a baculovirus expression system and functionalised poly(acrylic acid) ligands.

Bioorg Med Chem 2007 Jun 2;15(12):4038-47. Epub 2007 Apr 2.

School of Biological Sciences, University of Reading, Whiteknights, Reading RG6 6AJ, UK.

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http://dx.doi.org/10.1016/j.bmc.2007.03.085DOI Listing
June 2007

Infection of human airway epithelium by human and avian strains of influenza a virus.

J Virol 2006 Aug;80(16):8060-8

Cystic Fibrosis/Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27759-7248, USA.

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http://dx.doi.org/10.1128/JVI.00384-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1563802PMC
August 2006

Changes in in vitro susceptibility of influenza A H3N2 viruses to a neuraminidase inhibitor drug during evolution in the human host.

J Antimicrob Chemother 2004 May 17;53(5):759-65. Epub 2004 Mar 17.

School of Animal and Microbial Sciences, University of Reading, Whiteknights PO Box 228, Reading RG6 6AJ.

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http://dx.doi.org/10.1093/jac/dkh155DOI Listing
May 2004

A conserved basic loop in hepatitis C virus p7 protein is required for amantadine-sensitive ion channel activity in mammalian cells but is dispensable for localization to mitochondria.

J Gen Virol 2004 Feb;85(Pt 2):451-461

Astbury Centre of Molecular Biology, School of Biochemistry and Microbiology, University of Leeds, Leeds LS2 9JT, UK.

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http://dx.doi.org/10.1099/vir.0.19634-0DOI Listing
February 2004

Restrictions to the adaptation of influenza a virus h5 hemagglutinin to the human host.

J Virol 2004 Jan;78(1):502-7

School of Animal and Microbial Sciences, University of Reading, Reading RG6 6AJ, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC303389PMC
http://dx.doi.org/10.1128/jvi.78.1.502-507.2004DOI Listing
January 2004

A reverse genetics approach for recovery of recombinant influenza B viruses entirely from cDNA.

J Virol 2002 Nov;76(22):11744-7

University of Reading, Whiteknights, Reading RG6 6AJ. GlaxoSmithKline Medicine Research Centre, Stevenage SG1 2NY, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC136801PMC
http://dx.doi.org/10.1128/jvi.76.22.11744-11747.2002DOI Listing
November 2002

Isolation and characterization of a transfectant influenza B virus altered in RNA segment 6.

J Gen Virol 1999 Sep;80 ( Pt 9):2353-2359

School of Animal and Microbial Sciences, University of Reading, Whiteknights, PO Box 228, Reading RG6 6AJ, UK1.

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http://dx.doi.org/10.1099/0022-1317-80-9-2353DOI Listing
September 1999