Publications by authors named "Wendy Keung"

67Publications

Human ISL1 Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction.

Authors:
Kylie S Foo Miia L Lehtinen Chuen Yan Leung Xiaojun Lian Jiejia Xu Wendy Keung Lin Geng Terje R S Kolstad Sebastian Thams Andy On-Tik Wong Nicodemus Wong Kristine Bylund Chikai Zhou Xiaobing He Shao-Bo Jin Jonathan Clarke Urban Lendahl Ronald A Li William E Louch Kenneth R Chien

Mol Ther 2021 Jan 9;29(1):409. Epub 2020 Dec 9.

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January 2021

A Heart-Breast Cancer-on-a-Chip Platform for Disease Modeling and Monitoring of Cardiotoxicity Induced by Cancer Chemotherapy.

Authors:
Junmin Lee Shreya Mehrotra Elaheh Zare-Eelanjegh Raquel O Rodrigues Alireza Akbarinejad David Ge Luca Amato Kiavash Kiaee YongCong Fang Aliza Rosenkranz Wendy Keung Biman B Mandal Ronald A Li Ting Zhang HeaYeon Lee Mehmet Remzi Dokmeci Yu Shrike Zhang Ali Khademhosseini Su Ryon Shin

Small 2020 Oct 23:e2004258. Epub 2020 Oct 23.

Division of Engineering in Medicine, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, Cambridge, MA, 02139, USA.

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October 2020

Nonmulberry Silk Based Ink for Fabricating Mechanically Robust Cardiac Patches and Endothelialized Myocardium-on-a-Chip Application.

Authors:
Shreya Mehrotra Bruna A G de Melo Minoru Hirano Wendy Keung Ronald A Li Biman B Mandal Su Ryon Shin

Adv Funct Mater 2020 Mar 20;30(12). Epub 2020 Jan 20.

Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Cambridge, MA 02139, USA.

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March 2020

Single-Cell Transcriptomics of Engineered Cardiac Tissues From Patient-Specific Induced Pluripotent Stem Cell-Derived Cardiomyocytes Reveals Abnormal Developmental Trajectory and Intrinsic Contractile Defects in Hypoplastic Right Heart Syndrome.

Authors:
Yin-Yu Lam Wendy Keung Chun-Ho Chan Lin Geng Nicodemus Wong David Brenière-Letuffe Ronald A Li Yiu-Fai Cheung

J Am Heart Assoc 2020 Oct 16;9(20):e016528. Epub 2020 Oct 16.

Department of Paediatrics and Adolescent Medicine Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong SAR.

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October 2020

Circulating high-sensitivity troponin T and microRNAs as markers of myocardial damage during childhood leukaemia treatment.

Authors:
Yiu-Fai Cheung Vivian Wing-Yi Li Clare Tik-Man Lai Vivian Yvonne Shin Wendy Keung Daniel Ka-Leung Cheuk Ava Kwong Ronald Adolphus Li Godfrey Chi-Fung Chan

Pediatr Res 2020 Jul 7. Epub 2020 Jul 7.

Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

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July 2020

Combinatorial Treatment of Human Cardiac Engineered Tissues With Biomimetic Cues Induces Functional Maturation as Revealed by Optical Mapping of Action Potentials and Calcium Transients.

Authors:
Andy On-Tik Wong Nicodemus Wong Lin Geng Maggie Zi-Ying Chow Eugene K Lee Hongkai Wu Michelle Khine Chi-Wing Kong Kevin D Costa Wendy Keung Yiu-Fai Cheung Ronald A Li

Front Physiol 2020 12;11:165. Epub 2020 Mar 12.

Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong.

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March 2020

Human cardiac ventricular organoid chambers and tissue strips from pluripotent stem cells as a two-tiered assay for inotropic responses: A blinded validation.

Authors:
Wendy Keung Patrick K Chan Peter Backeris Eugene K Lee Nicodemus Wong Gabriel K Wong Camie W Chan Bernard Fermini Kevin D Costa Ronald A Li

J Pharmacol Toxicol Methods 2019 Sep - Oct;99:106595. Epub 2019 Oct 17.

Ming-Wai Lau Centre for Reparative Medicine, Karolinska Institutet, Hong Kong, Hong Kong; Novoheart, Vancouver, Canada.

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October 2019

Automated drug classification by machine learning analysis of drug screening data from human pluripotent stem cell-derived engineered cardiac tissue assays.

Authors:
Eugene K Lee David D Tran Wendy Keung Patrick K Chan Gabriel K Wong Camie W Chan Kevin D Costa Michelle Khine Ronald A Li

J Pharmacol Toxicol Methods 2019 Sep - Oct;99:106595. Epub 2019 Oct 17.

Novoheart, Vancouver, Canada; Ming-Wai Lau Centre for Reparative Medicine, Karolinska Institutet, Hong Kong, Hong Kong; Dr. Li Dak-Sum Research Centre, The University of Hong Kong, Pokfulam, Hong Kong.

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October 2019

"Human heart-in-a-Jar": An electro-mechanically functional miniature ventricular heart chamber from human pluripotent stem cells.

Authors:
Ronald A Li Wendy Keung Timothy Cashman Peter Backeris Bryce V Johnson Evan S Bardot Andy O-T Wong Patrick K Chan Camie W Chan Kevin D Costa

J Pharmacol Toxicol Methods 2019 Sep - Oct;99:106595. Epub 2019 Oct 17.

Novoheart, Vancouver, Canada; Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America.

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October 2019

Modeling the congenital heart condition of pulmonary atresia with intact ventricular septum using human induced pluripotent stem cells.

Authors:
Wendy Keung Yin Yu Lam Chun Ho Chan Lin Geng Yiu-Fai Cheung Ronald A Li

J Pharmacol Toxicol Methods 2019 Sep - Oct;99:106595. Epub 2019 Oct 17.

Dr. Li Dak-Sum Research Centre, The University of Hong Kong, Pokfulam, Hong Kong; Department of Paediatrics and Adolescent Medicine, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong; Ming Wai Lau Centre for Reparative Medicine, Karolinska Institutet, Hong Kong, Hong Kong.

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October 2019

Sarco/endoplasmic reticulum Ca-ATPase is a more effective calcium remover than sodium-calcium exchanger in human embryonic stem cell-derived cardiomyocytes.

Authors:
Sen Li Anant Chopra Wendy Keung Camie W Y Chan Kevin D Costa Chi-Wing Kong Roger J Hajjar Christopher S Chen Ronald A Li

Am J Physiol Heart Circ Physiol 2019 11 26;317(5):H1105-H1115. Epub 2019 Jul 26.

Dr. Li Dak-Sum Research Centre, The University of Hong Kong, Pokfulam, Hong Kong.

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November 2019

Modulation of chromatin remodeling proteins SMYD1 and SMARCD1 promotes contractile function of human pluripotent stem cell-derived ventricular cardiomyocyte in 3D-engineered cardiac tissues.

Authors:
Maggie Zi-Ying Chow Stephanie N Sadrian Wendy Keung Lin Geng Lihuan Ren Chi-Wing Kong Andy On-Tik Wong Jean-Sebastien Hulot Christopher S Chen Kevin D Costa Roger J Hajjar Ronald A Li

Sci Rep 2019 05 16;9(1):7502. Epub 2019 May 16.

Stem Cell and Regenerative Medicine Consortium, The University of Hong Kong, Pok Fu Lam, Hong Kong.

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May 2019

Structural and Mechanistic Bases of Nuclear Calcium Signaling in Human Pluripotent Stem Cell-Derived Ventricular Cardiomyocytes.

Authors:
Sen Li Wendy Keung Heping Cheng Ronald A Li

Stem Cells Int 2019 1;2019:8765752. Epub 2019 Apr 1.

Stem Cell & Regenerative Medicine Consortium, LKS Faculty of Medicine, University of Hong Kong, Hong Kong.

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April 2019

Human Cardiac Ventricular-Like Organoid Chambers and Tissue Strips From Pluripotent Stem Cells as a Two-Tiered Assay for Inotropic Responses.

Authors:
Wendy Keung Patrick K W Chan Peter C Backeris Eugene K Lee Nicodemus Wong Andy O T Wong Gabriel K Y Wong Camie W Y Chan Bernard Fermini Kevin D Costa Ronald A Li

Clin Pharmacol Ther 2019 08 28;106(2):402-414. Epub 2019 Mar 28.

Ming Wai Lau Centre for Reparative Medicine, Karolinska Institutet, Shatin, Hong Kong.

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August 2019

Probing flecainide block of I using human pluripotent stem cell-derived ventricular cardiomyocytes adapted to automated patch-clamping and 2D monolayers.

Authors:
Lin Geng Chi-Wing Kong Andy O T Wong Angie Man-Yee Shum Maggie Z Y Chow Hui Che Chenzi Zhang Ka-Long Yau Camie W Chan Wendy Keung Ronald A Li

Toxicol Lett 2018 Sep 21;294:61-72. Epub 2018 May 21.

Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong; Dr. Li Dak-Sum Research Centre, The University of Hong Kong, Hong Kong; Ming Wai Lau Centre for Reparative Medicine, Karolinska Institutet, Hong Kong. Electronic address:

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September 2018

TRPV6 protects ER stress-induced apoptosis via ATF6α-TRPV6-JNK pathway in human embryonic stem cell-derived cardiomyocytes.

Authors:
Zhichao Li Zhaoyue Meng Jun Lu Francis M Chen Wing-Tak Wong Gary Tse Changbo Zheng Wendy Keung Kennis Tse Ronald A Li Liwen Jiang Xiaoqiang Yao

J Mol Cell Cardiol 2018 07 16;120:1-11. Epub 2018 May 16.

School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China; Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Hong Kong, China; Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, Hong Kong, China. Electronic address:

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July 2018

Human ISL1 Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction.

Authors:
Kylie S Foo Miia L Lehtinen Chuen Yan Leung Xiaojun Lian Jiejia Xu Wendy Keung Lin Geng Terje R S Kolstad Sebastian Thams Andy On-Tik Wong Nicodemus Wong Kristine Bylund Chikai Zhou Xiaobing He Shao-Bo Jin Jonathan Clarke Urban Lendahl Ronald A Li William E Louch Kenneth R Chien

Mol Ther 2018 07 17;26(7):1644-1659. Epub 2018 Feb 17.

Department of Medicine, Karolinska Institutet, Huddinge, Sweden; Department of Cell and Molecular Biology, Karolinska Institutet, Solna, Sweden. Electronic address:

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July 2018

Bioengineering an electro-mechanically functional miniature ventricular heart chamber from human pluripotent stem cells.

Authors:
Ronald A Li Wendy Keung Timothy J Cashman Peter C Backeris Bryce V Johnson Evan S Bardot Andy O T Wong Patrick K W Chan Camie W Y Chan Kevin D Costa

Biomaterials 2018 05 10;163:116-127. Epub 2018 Feb 10.

Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Novoheart Limited, Shatin, Hong Kong. Electronic address:

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May 2018

Polycystin-2 Plays an Essential Role in Glucose Starvation-Induced Autophagy in Human Embryonic Stem Cell-Derived Cardiomyocytes.

Authors:
Jun Lu Kenneth R Boheler Liwen Jiang Camie W Chan Wan Wai Tse Wendy Keung Ellen Ny Poon Ronald A Li Xiaoqiang Yao

Stem Cells 2018 04 3;36(4):501-513. Epub 2018 Jan 3.

School of Biomedical Sciences and Li Ka Shing Institute of Health Sciences, Faculty of Medicine, the Chinese University of Hong Kong, Hong Kong, People's Republic of China.

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April 2018

Effects of pharmacological gap junction and sodium channel blockade on S1S2 restitution properties in Langendorff-perfused mouse hearts.

Authors:
Gary Tse Tong Liu Guangping Li Wendy Keung Jie Ming Yeo Yin Wah Fiona Chan Bryan P Yan Yat Sun Chan Sunny Hei Wong Ronald A Li Jichao Zhao William K K Wu Wing Tak Wong

Oncotarget 2017 Oct 28;8(49):85341-85352. Epub 2017 Jul 28.

School of Life Sciences, Chinese University of Hong Kong, Hong Kong, China.

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October 2017