Publications by authors named "Wenche Rødseth Brede"

12 Publications

  • Page 1 of 1

Severe Neurological Sequelae after a Recreational Dose of LSD.

J Anal Toxicol 2020 Oct 8. Epub 2020 Oct 8.

Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim.

A young man with an unremarkable medical history suffered a seizure with subsequent cardiorespiratory arrest and severe neurological sequelae after ingesting a blotter. Analysis of a similar blotter and a serum sample obtained 3 hours after the event detected lysergic acid diethylamide (LSD) at the amount of 300 μg in the blotter and at a concentration of 4.0 ng/mL (12.4 nmoles/L) in serum. No other drugs were present in concentrations which may confer significant effects. In addition, no individual traits which would make the patient particularly susceptible to adverse LSD effects have subsequently been identified. This suggests that LSD may confer toxic effects in previously healthy individuals.
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http://dx.doi.org/10.1093/jat/bkaa145DOI Listing
October 2020

Mucosal 5-aminosalicylic acid concentration, drug formulation and mucosal microbiome in patients with quiescent ulcerative colitis.

Aliment Pharmacol Ther 2019 05 20;49(10):1301-1313. Epub 2019 Mar 20.

Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.

Background: 5-aminosalicylic acid (5-ASA) is the first-line therapy for ulcerative colitis (UC). 5-ASA acts locally in the colonic mucosa by numerous proposed mechanisms, and is metabolised by N-acetyltransferase (NAT). Large variations in mucosal 5-ASA concentrations have been reported, but the underlying mechanisms are not understood.

Aim: To study the relationship between 5-ASA concentration, 5-ASA formulation, NAT genotype and bacterial microbiome in patients with UC.

Methods: Patients with quiescent UC, using monotherapy of Mezavant (n = 18), Asacol (n = 14) or Pentasa (n = 10), 4.0-4.8 g/day were included. 5-ASA was measured in colonic mucosal biopsies and serum by ultra-high performance liquid chromatography. NAT genotypes were determined by Sanger sequencing. Bacterial microbiome was sequenced from faeces and mucosa by 16S rRNA sequencing using Illumina Miseq.

Results: Mezavant provided the highest mucosal 5-ASA levels (geometric mean 2.39 ng/mg), followed by Asacol (1.60 ng/mg, 33% lower, P = 0.50) and Pentasa (0.57 ng/mg, 76% lower, P = 0.033). Mucosal 5-ASA concentration was not associated with NAT genotype, but serum 5-ASA concentration and NAT1 genotype was associated (P = 0.044). Mucosal 5-ASA concentration was positively associated with mucosal bacterial diversity (P = 0.0005) and bacterial composition. High mucosal 5-ASA concentration was related to reduced abundance of pathogenic bacteria such as Proteobacteria, and increased abundance of several favourable bacteria such as Faecalibacterium.

Conclusions: Mucosal 5-ASA concentration is positively associated with bacterial diversity and a mucosal bacterial composition that are perceived favourable in UC. Mezavant yielded higher mucosal 5-ASA concentrations than Pentasa. 5-ASA may have beneficial effects on the mucosal microbiome, and high concentrations possibly amend dysbiosis in UC.
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http://dx.doi.org/10.1111/apt.15227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593792PMC
May 2019

A Wolf in Sheep's Clothing.

J Anal Toxicol 2019 03;43(2):e7-e8

Department of Clinical Pharmacology, St. Olav University Hospital, Trondheim, Norway.

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http://dx.doi.org/10.1093/jat/bky080DOI Listing
March 2019

Two Hospitalizations and One Death After Exposure to Ortho-Fluorofentanyl.

J Anal Toxicol 2017 Oct;41(8):708-709

Department of Clinical Pharmacology, St. Olav University Hospital.

Two young males were hospitalized with miosis and respiratory dysfunction after exposure to a white powder obtained from a foreign source by mail. A few days later, one of the males was found dead at his home. A serum sample from one of the hospitalized patients and a blood sample from the deceased contained ortho-fluorofentanyl in concentrations of 2.5 and 2.4 ng/mL, respectively. It was concluded that death was caused by ortho-fluorofentanyl.
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http://dx.doi.org/10.1093/jat/bkx050DOI Listing
October 2017

Sudden Cardiac Death Following Use of the Synthetic Cannabinoid MDMB-CHMICA.

J Anal Toxicol 2016 Jan-Feb;40(1):86-7. Epub 2015 Sep 9.

Department of Clinical Pharmacology, St. Olav University Hospital, Trondheim, Norway Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim, Norway

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http://dx.doi.org/10.1093/jat/bkv110DOI Listing
August 2016

[A man with a changed appearance].

Tidsskr Nor Laegeforen 2015 Feb 10;135(3):243-5. Epub 2015 Feb 10.

Avdeling for klinisk farmakologi St. Olavs hospital.

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http://dx.doi.org/10.4045/tidsskr.14.0886DOI Listing
February 2015

Transfer of aripiprazole to breast milk: a case report.

J Clin Psychopharmacol 2014 Apr;34(2):272-5

School of Pharmacy University of Oslo and Division of Mental Health Norwegian Institute of Public Health Oslo, Norway Department of Obstetrics and Gynecology Drammen Hospital VVHF Drammen, Norway Department of Clinical Pharmacology St Olav's University Hospital Trondheim, Norway Department of Clinical Pharmacology St Olav's University Hospital and Department of Laboratory Medicine Children's and Women's Health Norwegian University of Science and Technology Trondheim, Norway.

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http://dx.doi.org/10.1097/JCP.0000000000000079DOI Listing
April 2014

Synthetic cannabis.

Tidsskr Nor Laegeforen 2012 Oct;132(20):2289

Department of Clinical Pharmacology, St. Olav University Hospital, Norway.

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http://dx.doi.org/10.4045/tidsskr.12.0661DOI Listing
October 2012

Lipid-lowering effects of tetradecylthioacetic acid in antipsychotic-exposed, female rats: challenges with long-term treatment.

PLoS One 2012 30;7(11):e50853. Epub 2012 Nov 30.

Dr. Einar Martens' Research Group for Biological Psychiatry, Department of Clinical Medicine, University of Bergen, Bergen, Hordaland, Norway.

Background: Psychiatric patients often require chronic treatment with antipsychotic drugs, and while rats are frequently used to study antipsychotic-induced metabolic adverse effects, long-term exposure has only partially mimicked the appetite-stimulating and weight-inducing effects found in the clinical setting. Antipsychotic-induced effects on serum lipids are also inconsistent in rats, but in a recent study we demonstrated that subchronic treatment with the orexigenic antipsychotic olanzapine resulted in weight-independent increase in serum triglycerides and activation of lipogenic gene expression in female rats. In addition, a recent long-term study in male rats showed that chronic treatment with antipsychotic drugs induced dyslipidemic effects, despite the lack of weight gain.

Aims: In the current study, we sought to examine long-term effects of antipsychotic drugs on weight gain, lipid levels and lipid composition after twice-daily administration of antipsychotics to female rats, and to investigate potential beneficial effects of the lipid-lowering agent tetradecylthioacetic acid (TTA), a modified fatty acid.

Methods: Female rats were exposed to orexigenic antipsychotics (olanzapine or clozapine), metabolically neutral antipsychotics (aripiprazole or ziprasidone), or TTA for 8 weeks. Separate groups received a combination of clozapine and TTA or olanzapine and TTA. The effects of TTA and the combination of olanzapine and TTA after 2 weeks were also investigated.

Results: The antipsychotic-induced weight gain and serum triglyceride increase observed in the subchronic setting was not present after 8 weeks of treatment with antipsychotics, while lipid-lowering effect of TTA was much more pronounced in the chronic than in the subchronic setting, with concomitant upregulation of key oxidative enzymes in the liver. Unexpectedly, TTA potentiated weight gain in rats treated with antipsychotics.

Conclusion: TTA is a promising candidate for prophylactic treatment of antipsychotic-induced dyslipidemic effects, but a more valid long-term rat model for antipsychotic-induced metabolic adverse effects is required.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0050853PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511315PMC
May 2013

[A bottle with unknown content].

Tidsskr Nor Laegeforen 2011 Nov;131(21):2131

Avdeling for klinisk farmakologi, St. Olavs hospital, Norway.

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http://dx.doi.org/10.4045/tidsskr.11.0374DOI Listing
November 2011

[Paramethoxymethamphetamine].

Tidsskr Nor Laegeforen 2011 Oct;131(20):2008

Avdeling for klinisk farmakologi, St. Olavs Hospital, Norway.

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http://dx.doi.org/10.4045/tidsskr.11.0950DOI Listing
October 2011