Publications by authors named "Wenbo Huang"

34 Publications

The Neurotrophic Effects and Mechanism of Action for FK1706 in Neurorrhaphy Rat Models and SH-SY5Y Cells.

Neurochem Res 2021 Jul 6. Epub 2021 Jul 6.

Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan Province, China.

FK1706 is a novel non-immunosuppressive immunophilin ligand with neurotrophic activity and exerts its neurotrophic effect through NGF. The present study aimed to elaborate on the neurotrophic activity and the mechanism of action of FK1706 in end-to-side neurorrhaphy rats and SH-SY5Y cells. In the regenerating nerves of neurorrhaphy rats, FK1706 increased the thickness of myelin sheath and the level of nerve regeneration-related proteins. The mechanism of action of FK1706 on neurite regrowth was elucidated in vitro by incubating SH-SY5Y cells in different conditions (Control, NGF, FK1706, NGF + FK1706, NGF + FK1706 + geldanamycin). Under the conditions where NGF was used, the phosphorylation level of major proteins (Raf-1 and ERK) in the Ras/Raf/MAPK/ERK signaling pathway related to SH-SY5Y cell proliferation was significantly enhanced following the application of FK1706. The number of viable cells, cell viability and neurite length of SH-SY5Y cells was maximal when NGF and FK1706 were used simultaneously. The binding level of HSP90 and Raf-1 in FK1706 group was the highest. These results indicated that FK1706 could significantly promote nerve regeneration after neurorrhaphy. The putative mechanism of action stated that FK1706 could promote the binding of HSP90 and Raf-1, make Raf-1 continue to be activated, thereby affecting key proteins in the Ras/Raf/MAPK/ERK signaling pathway related to the neurotrophic effects of NGF to promote the proliferation and neurite regrowth of nerve cells.
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http://dx.doi.org/10.1007/s11064-021-03391-1DOI Listing
July 2021

The convolutional neural networks training with Channel-Selectivity for human activity recognition based on sensors.

IEEE J Biomed Health Inform 2021 Jun 25;PP. Epub 2021 Jun 25.

Recently, the state-of-the-art performance in various sensor based human activity recognition (HAR) tasks have been acquired by deep learning, which can extract automatically features from raw data. In order to obtain the best accuracy, many static layers have been always used to train deep neural networks, and their weight connectivity in network remains unchanged. Pursuing the best accuracy in mobile platforms with a very limited computational budget at millions of FLOPs is impractical. In this paper, we make use of shallow convolutional neural networks (CNNs) with channel-selectivity for the use of HAR. As we have known, it is for the first time to adopt channel-selectivity CNN for sensor based HAR tasks. We perform extensive experiments on 5 public benchmark HAR datasets consisting of UCI-HAR dataset, OPPORTUNITY dataset, UniMib-SHAR dataset, WISDM dataset, and PAMAP2 dataset. As a result, the channel-selectivity can achieve lower test errors than static layers. The existing performance of deep HAR can be further improved by the CNN with channel-selectivity without any extra cost.
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http://dx.doi.org/10.1109/JBHI.2021.3092396DOI Listing
June 2021

Identification of Carbazole Alkaloid Derivatives with Acylhydrazone as Novel Anti-TMV Agents with the Guidance of a Digital Fluorescence Visual Screening.

J Agric Food Chem 2021 Jul 24;69(26):7458-7466. Epub 2021 Jun 24.

State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei 430070, P. R. China.

Difficulty in preventing crops from plant viruses urges to discover novel efficient antiviral chemicals, which is sped up by precise screening methods. Fluorescence-based methods have recently been applied as innovative and rapid tools for visually monitoring the replication of viruses and screening of antivirals, whereas the quantification of fluorescence signals mainly depends on manually calculating the fluorescent spots, which is time-consuming and imprecise. In the present work, the fluorescence spots were automatically identified, and the fluorescence area was directly quantified by a program developed in our group, which avoided subjective errors from the operators. We further employed this digital and visual screening assay to identify antivirals using the tobacco mosaic virus-green fluorescence protein (TMV-GFP) construct, in which the expression of GFP intuitively reflected the efficacy of antivirals. The accuracy of this assay was validated by quantifying the activities of the commercial antiviral inhibitors ribavirin and ningnanmycin and then was applied to evaluate the subtle activity differences of a series of newly synthesized carbazole and β-carboline alkaloid derivatives. Among them, compounds (76%) and (63%) exhibited anti-TMV activities comparable to that of ningnanmycin (65%) at 50 μM, and they delayed the multiplication of TMV in the early stage of infection without phytotoxicity. Taken together, these findings demonstrated that the digital and visual TMV-GFP screening method was competent to test the antiviral activities of compounds with subtle modifications and facilitated the discovery of novel antivirals.
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http://dx.doi.org/10.1021/acs.jafc.1c00897DOI Listing
July 2021

Data-Driven and Machine-Learning Methods to Project Coronavirus Disease 2019 Pandemic Trend in Eastern Mediterranean.

Front Public Health 2021 13;9:602353. Epub 2021 May 13.

Beijing Engineering Research Center of Food Environment and Public Health, Minzu University of China, Beijing, China.

The coronavirus disease 2019 (COVID-19) pandemic has become a major public health crisis worldwide, and the Eastern Mediterranean is one of the most affected areas. We use a data-driven approach to assess the characteristics, situation, prevalence, and current intervention actions of the COVID-19 pandemic. We establish a spatial model of the spread of the COVID-19 pandemic to project the trend and time distribution of the total confirmed cases and growth rate of daily confirmed cases based on the current intervention actions. The results show that the number of daily confirmed cases, number of active cases, or growth rate of daily confirmed cases of COVID-19 are exhibiting a significant downward trend in Qatar, Egypt, Pakistan, and Saudi Arabia under the current interventions, although the total number of confirmed cases and deaths is still increasing. However, it is predicted that the number of total confirmed cases and active cases in Iran and Iraq may continue to increase. The COVID-19 pandemic in Qatar, Egypt, Pakistan, and Saudi Arabia will be largely contained if interventions are maintained or tightened. The future is not optimistic, and the intervention response must be further strengthened in Iran and Iraq. The aim of this study is to contribute to the prevention and control of the COVID-19 pandemic.
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http://dx.doi.org/10.3389/fpubh.2021.602353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158576PMC
June 2021

Selective and effective anticancer agents: Synthesis, biological evaluation and structure-activity relationships of novel carbazole derivatives.

Bioorg Chem 2021 Aug 18;113:104991. Epub 2021 May 18.

National Biopesticide Engineering Research Centre, Hubei Biopesticide Engineering Research Centre, Hubei Academy of Agricultural Sciences, Wuhan 430064, China. Electronic address:

Carbazole alkaloids is an important class of natural products with diverse biological functions. So, the aim of this article is to explore new chemical entities containing carbazole scaffold as potential novel cytotoxic agents based on our developed three-component indole-to-carbazole reaction. Two series of carbazole derivatives were designed and synthesized, and their in vitro cytotoxic activities against three cell lines (A875, HepG2, and MARC145) were evaluated. The results indicated that some of these carbazole derivatives exhibited significantly good cytotoxic activities against tested cell lines compared with the control 5-fluorouracil (5-FU). Especially, carbazole acylhydrazone compounds 7g and 7p displayed high inhibitory activity on cancer cells, but almost no activity on normal cells. Further analysis of induced apoptosis for potential compounds indicated that the potential antitumor agents induced cell death in A875 cells at least partly (initially) by apoptosis, which might be used as promising lead scaffold for discovery of novel carbazole-type cytotoxic agents.
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http://dx.doi.org/10.1016/j.bioorg.2021.104991DOI Listing
August 2021

In vivo monitoring of volatile metabolic trajectories enables rapid diagnosis of influenza A infection.

Chem Commun (Camb) 2021 May 15;57(39):4791-4794. Epub 2021 Apr 15.

Institute of Mass Spectrometry and Atmospheric Environment, Jinan University, Guangzhou 510632, China.

We report that influenza A virus infection induces changes in odor traits that could be captured by real-time high-resolution mass spectrometry in a living mouse model. The most striking changes in the volatile metabolites may be associated mostly to glyoxylate/dicarboxylate metabolism.
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http://dx.doi.org/10.1039/d1cc01061aDOI Listing
May 2021

Lianhuaqingwen capsule inhibits influenza-induced bacterial adhesion to respiratory epithelial cells through down-regulation of cell adhesion molecules.

J Ethnopharmacol 2021 Apr 16:114128. Epub 2021 Apr 16.

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, PR China; Faculty of Chinese Medicine, Macau University of Science and Technology, Taipa, Macau SAR, PR China. Electronic address:

Ethnopharmacological Relevance: Influenza virus infection is widely believed to cause mild symptoms, but can lead to high mortality and severe disease complicated by secondary bacterial pneumonia. Traditional Chinese medicine (TCM) has been proposed as a promising agent to treat respiratory viral infections. An herbal formula Lianhuaqingwen capsule (LHQW) comprising two prescriptions: Maxing Shigan decoction and Yinqiao San, has been used clinically to treat respiratory infection with immune regulatory effects. However, little is known about the capacity of LHQW against influenza-induced secondary bacterial pneumonia.

Aim Of Study: This study aimed to evaluate the efficacy and underlying mechanism of LHQW on influenza A virus A/PR/8/34 (PR8) secondary methicillin-resistant Staphy-lococcus aureus (MRSA) infection.

Methods: The anti-adhesion activity of LHQW against PR8-induced MRSA infection was assessed in human lung epithelial (A549) cells and the effect of LHQW on the expression of intracellular adhesion molecule 1 (ICAM-1) was detected. Also, the mRNA expression levels of inflammatory cytokines upon lipopolysaccharide (LPS) stimulation in PR8-infected A549 cells were determined. The body weight change, survivals, viral titers, colonies and the pathological parameters after LHQW treatment in severe pneumonia model have all been systematically determined.

Results: LHQW significantly reduced the adhesion of MRSA to PR8-infected A549 cells in a dose-dependent manner by suppressing the up-regulation of bacterial receptors. LHQW also markedly declined the overexpression of IL-6, IL-8, and TNF-α induced by LPS stimulated-A549 cells following influenza virus infection. Furthermore, the abnormal changes of lung index in dual-infection mice were relieved after administered with LHQW in preventive and therapeutic mode, but with no significantly difference (P>0.05). LHQW could not effectively improve survival rate or prolong the survival time of mice (P>0.05). LHQW (1000 mg/kg/d) administered prophylactically significantly decreased the lung viral titers (P<0.05), slightly downregulated IL-6 but TNF-α, IL-1β levels and improved lung pathological inflammation including neutrophil infiltration, necrosis, which is consistent with the expression of inflammatory factors.

Conclusions: LHQW inhibited influenza-induced bacterial adhesion by down-regulating the adhesion molecules with the improvement trend on severe pneumonia, indicating that it can be used as an adjuvant medication in severe viral-bacterial pneumonia therapy rather than as a single medication.
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http://dx.doi.org/10.1016/j.jep.2021.114128DOI Listing
April 2021

In Situ-Doped Superacid in the Covalent Triazine Framework Membrane for Anhydrous Proton Conduction in a Wide Temperature Range from Subzero to Elevated Temperature.

ACS Appl Mater Interfaces 2021 Mar 14;13(11):13604-13612. Epub 2021 Mar 14.

School of Chemical Engineering and Technology, Shaanxi Key Laboratory of Energy Chemical Process Intensification, Xi'an Jiaotong University, Xi'an 710049, China.

Synthesis of solid-state proton-conducting membranes with low activation energy and high proton conductivity under anhydrous conditions is a great challenge. Here, we show a simple and convenient way to prepare covalent triazine framework membranes (CTF-Mx) with acid in situ doping for anhydrous proton conduction in a wide temperature range from subzero to elevated temperature (160 °C). The low proton dissociation energy and continuous hydrogen bond network in CTF-Mx make the membrane achieve high proton conductivity from 1.21×10 S cm (-40 °C) to 2.08×10 S cm (160 °C) under anhydrous conditions. Molecular dynamics and proton relaxation time analyses reveal proton hopping at low activation energies with greatly enhanced mobility in the CTF membranes.
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http://dx.doi.org/10.1021/acsami.1c01134DOI Listing
March 2021

Three-component reactions of aromatic amines, 1,3-dicarbonyl compounds, and α-bromoacetaldehyde acetal to access -(hetero)aryl-4,5-unsubstituted pyrroles.

Beilstein J Org Chem 2020 30;16:2920-2928. Epub 2020 Nov 30.

School of Chemistry and Chemical Engineering, The Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, Shihezi University, Shihezi City 832004, China.

-(Hetero)aryl-4,5-unsubstituted pyrroles were synthesized from (hetero)arylamines, 1,3-dicarbonyl compounds, and α-bromoacetaldehyde acetal by using aluminum(III) chloride as a Lewis acid catalyst through [1 + 2 + 2] annulation. This new versatile methodology provides a wide scope for the synthesis of different functional -(hetero)aryl-4,5-unsubstituted pyrrole scaffolds, which can be further derived to access multisubstituted pyrrole-3-carboxamides. In the presence of 1.2 equiv of KI, a polysubstituted pyrazolo[3,4-]pyridine derivative was also successfully synthesized.
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http://dx.doi.org/10.3762/bjoc.16.241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7722624PMC
November 2020

Adsorptive Separation of Aromatic Compounds from Alkanes by π-π Interactions in a Carbazole-Based Conjugated Microporous Polymer.

ACS Appl Mater Interfaces 2020 Dec 3;12(50):56385-56392. Epub 2020 Dec 3.

School of Chemical Engineering and Technology, Xi'an Jiaotong University, Xi'an 710049, P. R. China.

Separation of aromatic/alkane mixtures of similar size and properties is critical for the chemical industry as conventional thermal separation is a high-cost and an energy-intensive process. Adsorptive separation based on porous materials is a prospective and economical technology as well as a suitable alternative to the energy-inefficient heat-driven separation process. With this in mind, we design and synthesize a novel microporous polymer (termed CMP-S-1) with a conjugated aromatic skeleton as a porous adsorbent for aromatic/alkane separation. CMP-S-1 possesses high aromatic adsorption selectivity in two representative separation systems (benzene vs cyclohexane and 3-methylthiophene vs -octane) based on a vapor adsorption experiment and an ideal adsorbed solution theory simulation. The instant adsorption rate, adsorption energy calculations, and liquid fixed-bed breakthrough experiments give convincing demonstrations on the preferential selective adsorption of aromatic compounds over alkanes in CMP-S-1. The strong π-π interaction between aromatics and the naphthalene ring is considered as the main reason for the strong affinity of aromatic compounds in the CMP-S-1 skeleton. The remarkable aromatic/alkane separation performance of CMP-S-1 verifies the important influence of the π-conjugation interaction in the conjugated porous polymer for the low-energy consumption adsorption separation process.
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http://dx.doi.org/10.1021/acsami.0c18232DOI Listing
December 2020

Discovery of γ-Lactam Alkaloid Derivatives as Potential Fungicidal Agents Targeting Steroid Biosynthesis.

J Agric Food Chem 2020 Dec 22;68(49):14438-14451. Epub 2020 Nov 22.

National Biopesticide Engineering Research Centre, Hubei Biopesticide Engineering Research Centre, Hubei Academy of Agricultural Science, Wuhan 430064, China.

Biological control of plant pathogens is considered as one of the green and effective technologies using beneficial microorganisms or microbial secondary metabolites against plant diseases, and so microbial natural products have played important roles in the research and development of new and green agrochemicals. To explore the potential applications for natural γ-lactam alkaloids and their derivatives, 26 γ-lactams that have flexible substituent patterns were synthesized and characterized, and their antifungal activities against eight kinds of plant pathogens belonging to oomycetes, basidiomycetes, and deuteromycetes were fully evaluated. In addition, the high potential compounds were further tested using an assay against blight of pepper to verify a practical application for controlling oomycete diseases. The potential modes of action for compound against were also investigated using microscopic technology (optical microscopy, scanning electron microscopy, and transmission electron microscopy) and label-free quantitative proteomics analysis. The results demonstrated that compound may be a potential novel fungicidal agent against oomycete diseases (EC = 4.9748 μg·mL for and EC = 5.1602 μg·mL for ) that can act on steroid biosynthesis, which can provide a certain theoretical basis for the development of natural lactam derivatives as potential antifungal agents.
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http://dx.doi.org/10.1021/acs.jafc.0c05823DOI Listing
December 2020

Two-Dimensional Metal-Polyphthalocyanine Conjugated Porous Frameworks as Promising Optical Limiting Materials.

ACS Appl Mater Interfaces 2020 Oct 1;12(41):46565-46570. Epub 2020 Oct 1.

School of Chemical Engineering and Technology, Xi'an Jiaotong University, Xi'an 710049, China.

Two-dimensional transition-metal-containing polyphthalocyanine conjugated porous frameworks are synthesized, and transition-metal (TM) ions ranging from Fe, Co, Ni, Cu to In are chosen to combine in phthalocyanine centers to tune their delocalized electronic structure. The fully closed planar delocalized π-conjugated frameworks exhibit efficient nonlinear optical absorption and excellent optical limiting performance under ns pulsed laser. The metal ion (Co, Ni) with ferromagnetism in phthalocyanine center manifests its contribution in enhanced nonlinear optical response through resonance enhancement of the nonlinear excited-state absorption.
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http://dx.doi.org/10.1021/acsami.0c13990DOI Listing
October 2020

Phillyrin (KD-1) exerts anti-viral and anti-inflammatory activities against novel coronavirus (SARS-CoV-2) and human coronavirus 229E (HCoV-229E) by suppressing the nuclear factor kappa B (NF-κB) signaling pathway.

Phytomedicine 2020 Nov 1;78:153296. Epub 2020 Aug 1.

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China; State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR, China; KingMed Virology Diagnostic & Translational Center, Guangzhou, China. Electronic address:

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has extensively and rapidly spread in the world, causing an outbreak of acute infectious pneumonia. However, no specific antiviral drugs or vaccines can be used. Phillyrin (KD-1), a representative ingredient of Forsythia suspensa, possesses anti-inflammatory, anti-oxidant, and antiviral activities. However, little is known about the antiviral abilities and mechanism of KD-1 against SARS-CoV-2 and human coronavirus 229E (HCoV-229E).

Purpose: The study was designed to investigate the antiviral and anti-inflammatory activities of KD-1 against the novel SARS-CoV-2 and HCoV-229E and its potential effect in regulating host immune response in vitro.

Methods: The antiviral activities of KD-1 against SARS-CoV-2 and HCoV-229E were assessed in Vero E6 cells using cytopathic effect and plaque-reduction assay. Proinflammatory cytokine expression levels upon infection with SARS-CoV-2 and HCoV-229E infection in Huh-7 cells were measured by real-time quantitative PCR assays. Western blot assay was used to determine the protein expression of nuclear factor kappa B (NF-κB) p65, p-NF-κB p65, IκBα, and p-IκBα in Huh-7 cells, which are the key targets of the NF-κB pathway.

Results: KD-1 could significantly inhibit SARS-CoV-2 and HCoV-229E replication in vitro. KD-1 could also markedly reduce the production of proinflammatory cytokines (TNF-α, IL-6, IL-1β, MCP-1, and IP-10) at the mRNA levels. Moreover, KD-1 could significantly reduce the protein expression of p-NF-κB p65, NF-κB p65, and p-IκBα, while increasing the expression of IκBα in Huh-7 cells.

Conclusions: KD-1 could significantly inhibit virus proliferation in vitro, the up-regulated expression of proinflammatory cytokines induced by SARS-CoV-2 and HCoV-229E by regulating the activity of the NF-кB signaling pathway. Our findings indicated that KD-1 protected against virus attack and can thus be used as a novel strategy for controlling the coronavirus disease 2019.
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http://dx.doi.org/10.1016/j.phymed.2020.153296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395229PMC
November 2020

Sulfur-containing natural hinduchelins derivatives as potential antifungal agents against Rhizoctonia solani.

Bioorg Med Chem Lett 2020 07 5;30(13):127245. Epub 2020 May 5.

National Biopesticide Engineering Research Centre, Hubei Biopesticide Engineering Research Centre, Hubei Academy of Agricultural Sciences, Wuhan 430064, People's Republic of China. Electronic address:

Aryl-oxazole alkaloids are an important class of heterocyclic natural products, and which has been demonstrated to exhibit broad biological functions. During the course of our research for highly active compounds from natural products, the natural hinduchelins A-D with typical aryl-oxazole unit have been synthesized and investigated. So, in order to develop highly potential functional molecules, a series of novel sulfur-containing aryl-oxazole compounds derived from natural hinduchelins was designed and synthesized, and their in vitro fungicidal activities against four common plant pathogenic fungi (oomycetes Phytophthora capsici, ascomycetes Sclerotinia sclerotiorum, deuteromycetes Botrytis cinerea and basidiomycetes Rhizoctonia solani) were evaluated, the results demonstrated that compounds 7b and 7c displayed good selectivity and specificity in vitro against basidiomycetes R. solani. In addition, the in vivo antifungal activities also indicated compounds 7b and 7c can protect the horsebean against infection by R. solani, and the possible mechanism of antifungal action for these compounds has also been investigated.
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http://dx.doi.org/10.1016/j.bmcl.2020.127245DOI Listing
July 2020

Frequent recovery of influenza A but not influenza B virus RNA in aerosols in pediatric patient rooms.

Indoor Air 2020 09 13;30(5):805-815. Epub 2020 Apr 13.

WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.

Influenza transmission occurs through the air, but the relative importance of small droplets, or aerosols, in influenza transmission especially within healthcare facilities remains uncertain. Detections of influenza virus in aerosols in cough and exhaled breath from infected patients and from the air in outpatient or inpatient healthcare facilities have been studied, but most studies were done in adults with very few data involving children. We aimed to assess the potential of influenza transmission via aerosols in pediatric patient rooms. Two-stage cyclone (NIOSH) air samplers were used to collect the air in 5-bed pediatric patient rooms with patients with influenza-like illness. Influenza A virus RNA was recovered in 15/19 (79%) air sampling occasions with ≥1 patient with laboratory-confirmed influenza A virus infections, in all air size fractions (>4 µm, 1-4 µm and <1 µm). Influenza B virus RNA was significantly less detected (2/10 occasions, 20%). We estimated a ventilation rate of 1.46 ACH in a similar but unoccupied 5-bed patient room. High quantities of influenza A virus RNA detected in the air in pediatric patient rooms suggests other individuals in pediatric patient rooms including other patients, visitors, caretakers and healthcare workers could be exposed to influenza A virus in aerosols while caring for infected children.
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http://dx.doi.org/10.1111/ina.12669DOI Listing
September 2020

Characterization of the Volatiles and Quality of Hybrid Grouper and Their Relationship to Changes of Microbial Community During Storage at 4 °C.

Molecules 2020 Feb 13;25(4). Epub 2020 Feb 13.

College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China.

To investigate the effects of spoilage bacteria on aquatic product quality and volatile organic compounds (VOCs) in hybrid grouper ( ♀× ♂), the physical conditions were evaluated, the chemical changes including color, total volatile base nitrogen (TVB-N), VOCs, and free amino acids (FFAs) were determined, and biological profiles were made through microbial community (total viable counts (TVC), 16S rRNA gene amplification sequencing, and next-generation sequencing (NGS) technology on hybrid grouper, which were stored at 4 °C for 10 days. The results showed that the whiteness and TVB-N of grouper increased throughout the storage period. The contents of glycine, alanine, and total free amino acid decreased with the microbial activity towards the end of the study period. At the end of storage, the TVC reached 9.0 log10 (CFU/g). Seventy eight strains of bacteria were isolated from the hybrid grouper, most of which were shown to be spp, after 16S rRNA sequencing. The results of the NGS test showed that the diversity of dominant bacteria decreased with time; was the dominant spoilage bacteria at the end of storage. The VOCs of fish and bacteria in the grouper's spoilage process were presented in headspace solid-phase microextraction gas chromatography-mass spectrometry (HS-SPME-GC-MS). Twenty eight compounds were identified in hybrid grouper, among which alcohol and aldehyde were used to characterize freshness, both of which were not only related to the overall flavor of the grouper, but were also affected by microbial activity. However, due to the complexity of microbial communities in aquatic products, the correlation between community changes and VOCs needs further research. This study provides insights into the correlation between VOCs and specific spoilage organisms (SSOs) through the analysis of the microbial community and VOCs.
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http://dx.doi.org/10.3390/molecules25040818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070358PMC
February 2020

Liu Shen Wan inhibits influenza a virus and excessive virus-induced inflammatory response via suppression of TLR4/NF-κB signaling pathway in vitro and in vivo.

J Ethnopharmacol 2020 Apr 21;252:112584. Epub 2020 Jan 21.

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, PR China; Faculty of Chinese Medicine, Macau University of Science and Technology, Taipa, Macau SAR, PR China; KingMed Virology Diagnostic & Translational Center, Guangzhou, Guangdong, PR China. Electronic address:

Ethnopharmacological Relevance: Liu Shen Wan (LSW), first prescribed in "Lei Yunshang Song Fen Tang Fang", traditional Chinese medicine (TCM), is used to cure influenza, tonsillitis, pharyngitis and mumps for more than one hundred years.

Aim Of Study: LSW was proved extensive pharmacological properties, for instance, anti-inflammatory, anticancer, antiviral, analgesic, antibacterial and immunomodulatory activities. Nevertheless, the mechanism of this process and the evaluation of this product is still ambiguous. Hence, the study was designed to investigate the antiviral and anti-inflammatory activities of LSW against the influenza virus in vitro and vivo.

Materials And Methods: The antiviral activities of LSW were assayed in virus-infected cells and mice. To study the antiviral effects of LSW against influenza A/PR/8/34 virus (PR8), we employed CPE inhibition assay with different concentrations of LSW at different times of infection in vitro. The mice were intranasally infected with virus to induce viral pneumonia, then treated with different doses of LSW. The death protection of the mice, the lung index, virus titer and pathological changes in the lung tissue of mice were investigated to estimate the anti-virus effect of LSW. Moreover, RT-qPCR was used to determine the mRNA expression of TNF-α, IL-1β, IL-6, and IFN-γ in the A549 cells and the supernatant of lung tissues, and the concentrations of these four cytokines in serum of mice were determined with ELISA. Western blot was used to determine the expression of TLR4, p-NF-κB p65, NF-κB p65, p-IκBα and IκBα in the A549 cells and lung tissues, which are the key targets of TLR4/NF-κB pathway. Moreover, the immunohistochemical assay was used to determine the expression of the NF-κB p65 in the mice lungs.

Results: LSW could significantly inhibit influenza virus at different stages of viral replication (at the process of the pre-, post-, and co-virus infection) in vitro. And LSW (100 mg/kg and 50 mg/kg) could effectively increase the survival time of mice. The virus titres, lung index, pathological changes in the mice lungs also decreased. Moreover, LSW could significantly reduce the contents of IL-1β, TNF-α, IFN-γ and IL-6 in the infected cells and the infected-mice. In addition, LSW could significantly reduce the expression of TLR4, p-NF-κB p65, NF-κB p65 and p-IκBα, while increase the IκBα in the infected cells and in the lung of mice.

Conclusions: LSW could significantly not only inhibit virus replication and proliferation in vitro, but also ameliorate pneumonia damage in vivo. The antiviral effect was attributed to down-regulating the expression of inflammatory cytokines induced by influenza virus via regulating the activity of TLR4/NF-кB signaling pathway.
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http://dx.doi.org/10.1016/j.jep.2020.112584DOI Listing
April 2020

Multi-perspective analyses of rice straw modification by Pleurotus ostreatus and effects on biomethane production.

Bioresour Technol 2020 Jan 5;296:122365. Epub 2019 Nov 5.

Department of Environmental Science and Engineering, Beijing University of Chemical Technology, 15 Beisanhuan East Road, Chaoyang District, Beijing 100029, PR China. Electronic address:

Multi-perspective analyses were carried out to investigate the effect of rice straw modification for 45 days by P. ostreatus on biomethane of production. The results showed that rice straw modified for 25 days achieved the highest biomethane yield of 269 mL·g VS, which was a 26.9% improvement compared with non-modified rice straw. The multi-perspective analyses demonstrated that the improvement resulted from fungal enzymatic reactions, which led to changes in the physicochemical properties of rice straw. The porosity, surface area, acetyl group abundance, degree of polymerization, and lignin degradation selectivity of rice straw modified for 25 days were optimal for enzyme adsorption. Compared with non-modified rice straw, the adsorption of cellulase and xylanase on rice straw modified for 25 days was increased by 18.8% and 58.1%, respectively, which facilitated biomethane production. The study indicated that P. ostreatus is effective for improving biomethane production from rice straw.
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http://dx.doi.org/10.1016/j.biortech.2019.122365DOI Listing
January 2020

An NF90/long noncoding RNA-LET/miR-548k feedback amplification loop controls esophageal squamous cell carcinoma progression.

J Cancer 2019 28;10(21):5139-5152. Epub 2019 Aug 28.

Department of Surgical Oncology, the Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, Fujian, China.

In our previous study we have found that miR-548k has oncogenic roles in esophageal squamous cell carcinoma (ESCC) via repressing long noncoding RNA (lncRNA)-LET and further upregulating nuclear factor 90 (NF90). However, the upstream factors controlling miR-548k expression are still unknown. In this study, we found NF90 directly binds pri-miR-548k, increases the stability of pri-miR-548k, and upregulates the expression of pri-miR-548k and miR-548k. Therefore, NF90, miR-548k and lncRNA-LET forms a feedback loop. Gain-of-function and loss-of-function assays demonstrated that in accordance with the roles of miR-548k, NF90 also promotes ESCC cell proliferation and migration. Furthermore, we verified the regulatory feedback loop between NF90, miR-548k, and lncRNA-LET. We found NF90 upregulated miR-548k and downregulated lncRNA-LET. miR-548k downregulated lncRNA-LET and upregulated NF90. lncRNA-LET downregulated NF90 and miR-548k. Through the reciprocal regulations between each other, the NF90/miR-548k/lncRNA-LET feedback loop controls the expressions of NF90 targets (HIF-1α and VEGF), miR-548k targets (KLF10 and EGFR), and lncRNA-LET target (p53). Further functional assays demonstrated that activation of the NF90/miR-548k/lncRNA-LET feedback loop via simultaneously overexpressing NF90 and miR-548k and simultaneously depleting lncRNA-LET significantly promotes ESCC cell proliferation and migration and ESCC tumor growth . Targeting the NF90/miR-548k/lncRNA-LET feedback loop via simultaneously depleting NF90 and miR-548k and simultaneously overexpressing lncRNA-LET significantly inhibits ESCC cell proliferation and migration and ESCC tumor growth . In summary, our findings identified a crucial oncogenic NF90/lncRNA-LET/miR-548k feedback amplification loop, which may be promising therapeutic targets for ESCC.
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http://dx.doi.org/10.7150/jca.30816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775607PMC
August 2019

Effect of Different Packaging Methods on Protein Oxidation and Degradation of Grouper () During Refrigerated Storage.

Foods 2019 Aug 7;8(8). Epub 2019 Aug 7.

College of Food Science & Technology, Shanghai Ocean University, Shanghai 201306, China.

This study investigates the effect of different packaging methods-namely, air packaging (AP), vacuum packaging (VP), and modified atmosphere packaging (MAP)-on the protein oxidation and degradation of grouper () fillets during refrigerated storage. The carbonyl group, myofibril fragmentation index, free amino acids, FTIR of myofibrillar proteins, and total protein SDS-PAGE were determined. The results showed that the protein oxidation degree of the fillets gradually increased as the storage time increased. The FTIR results indicated that the secondary structure transformed from an α-helix to an irregular curl. SDS-PAGE confirmed the degradation of the myosin heavy chain, and that myosin gradually occurred during refrigerated storage. Meanwhile, protein oxidation and degradation were highly correlated. Protein degradation was accelerated by protein oxidation in myofibrils, which included the increase of protein surface hydrophobicity and changes of the secondary structure. In fact, the protein oxidation and degradation of the grouper fillets were effectively inhibited by MAP and VP during refrigerated storage, and MAP (30% N and 70% CO) had the best results.
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http://dx.doi.org/10.3390/foods8080325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723294PMC
August 2019

Synthesis of Multisubstituted Pyrroles from Enolizable Aldehydes and Primary Amines Promoted by Iodine.

J Org Chem 2019 May 24;84(9):5655-5666. Epub 2019 Apr 24.

Key Laboratory of Material Chemistry for Energy Conversion and Storage, Ministry of Education, School of Chemistry and Chemical Engineering, Hubei Key Laboratory of Material Chemistry and Service Failure , Huazhong University of Science and Technology , 430074 Wuhan , China.

1,2,4-Trisubstituted pyrroles were synthesized from enolizable aliphatic aldehydes and primary aliphatic amines by using iodine as the dual Lewis acid/mild oxidant. In the presence of 3.0 equiv of TBHP, enolizable α,β-unsaturated aldehyde, for example, cocal reacted with aromatic primary amines to form C2-iodized N-arylpyrroles. An acetal-containing pyrrole was successfully prepared from 4-aminobutyraldehyde diethyl acetal, which can be converted easily to 5,6,7,8-tetrahydroindolizine derivatives.
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http://dx.doi.org/10.1021/acs.joc.9b00596DOI Listing
May 2019

Modification of corn stover for improving biodegradability and anaerobic digestion performance by Ceriporiopsis subvermispora.

Bioresour Technol 2019 Jul 7;283:76-85. Epub 2019 Feb 7.

Department of Environmental Science and Engineering, Beijing University of Chemical Technology, 15 Beisanhuan East Road, Chaoyang District, Beijing 100029, PR China. Electronic address:

Ceriporiopsis subvermispora was used to modify corn stover for improving the biodegradability and biomethane yield. Corn stover was incubated with C. subvermispora for 5-90 days then anaerobically digested. It was found that the corn stover modified for 15 days achieved the highest biomethane yield of 235 mL·g VS, which was an increase of 15.2% over that of the non-modified one. The mechanism analyses indicated that the improvement resulted from the combined roles of degradation selectivity, destruction of lignocellulosic structures, and linkages. The analyses showed that C. subvermispora has a high relative selectivity of lignin degradation. The structure of the lignin and the linkages among lignin and hemicellulose and cellulose were broken obviously by acetyl group removal, and the enzymatic hydrolysis of cellulose was increased by 35.61%. The finding indicated that C. subvermispora modification is one of the effective methods for enhancing biomethane yield of corn stover.
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http://dx.doi.org/10.1016/j.biortech.2019.02.035DOI Listing
July 2019

Lewis Acid-Catalyzed Synthesis of Benzofurans and 4,5,6,7-Tetrahydrobenzofurans from Acrolein Dimer and 1,3-Dicarbonyl Compounds.

J Org Chem 2019 03 15;84(5):2941-2950. Epub 2019 Feb 15.

Key Laboratory for Large-Format Battery Materials and System, Ministry of Education, School of Chemistry and Chemical Engineering , Huazhong University of Science and Technology , 430074 , Wuhan , China.

2,3-Disubstituted benzofurans were synthesized from acrolein dimer and 1,3-dicarbonyl compounds by using N-bromosuccinimide as an oxidizing agent. The method was used to synthesize two commercial drug molecules, benzbromarone and amiodarone. The proposed mechanism of the reaction involves a N-bromosuccinimide (NBS)-assisted autotandem catalysis with Lewis acid catalyst. To proof the proposed mechanism, an intermediate was isolated successfully, which can be converted to 4,5,6,7-tetrahydrobenzofurans.
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http://dx.doi.org/10.1021/acs.joc.9b00270DOI Listing
March 2019

Bismuth(III) Triflate Catalyzed Three-Component Reactions of Indoles, Ketones, and α-Bromoacetaldehyde Acetals Enable Indole-to-Carbazole Transformation.

Org Lett 2018 07 6;20(14):4285-4289. Epub 2018 Jul 6.

Key Laboratory of Material Chemistry for Energy Conversion and Storage, Ministry of Education, School of Chemistry and Chemical Engineering, Hubei Key Laboratory of Material Chemistry and Service Failure , Huazhong University of Science and Technology , 430074 , Wuhan , China.

A three-component reaction of indoles, α-bromoacetaldehyde acetals, and ketones was developed by using bismuth(III) triflate as the catalyst to realize a straightforward approach for synthesizing carbazole derivatives. The reaction was established mechanistically through the autotandem catalysis of Bi(OTf) in the following two steps: (i) Friedel-Crafts-type alkylation of indole with α-bromoacetaldehyde acetal, which produced a tryptaldehyde-type intermediate and (ii) [4 + 2] annulation of this intermediate with the ketone component.
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http://dx.doi.org/10.1021/acs.orglett.8b01707DOI Listing
July 2018

Decreasing HIV, Syphilis, and Hepatitis C Infection After a Decade of Harm Reduction Implementation Among Drug Users in Southwestern Areas of China.

J Stud Alcohol Drugs 2018 03;79(2):248-257

Guangxi Center for Disease Control and Prevention, Qingxiu District, Nanning, Guangxi, People's Republic of China.

Objective: Since 2003, the Chinese central government has implemented several harm reduction and preventive measures to control HIV. We aim to describe epidemiological trends of HIV, hepatitis C virus (HCV), and syphilis in Guangxi drug users after the policy implementation.

Method: A total of 12,161-15,870 drug users in Guangxi, China, were recruited annually from 2009 to 2015 through community outreach or snowball sampling. The participants' demographics, behavior, and infection status were used to characterize rates of protective behaviors and disease prevalence (HIV, syphilis, and HCV). Chi-squared trend testing was used.

Results: Relative to baseline, the prevalence of HIV, HCV, and syphilis decreased from 13.6% to 6.2%, 68.0% to 50.5%, and 8.5% to 5.2%, respectively, by 2015. Concurrently, the rate of injecting drugs, needle sharing, unprotected last sexual encounter, and regular unprotected intercourse decreased from 82.6% to 64.5%, 24.1% to 5.5%, 66.6% to 39.7%, and 74.0% to 51.2%, respectively. The usage of prevention services, methadone maintenance therapy or needle exchange, peer education programs, HIV testing in the previous year, and knowledge of HIV status increased from 63.4% to 93.6%, 52.0% to 56.6%, 37.4% to 43.1%, 45.3% to 91.3%, and 76.7% to 99.4%, respectively, from 2009 to 2015.

Conclusions: After a decade of HIV control policies, this was the first Chinese study to show a decreasing prevalence of HIV, HCV, and syphilis in the context of increasing uptake of protective services and behaviors.
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March 2018

Spatial distribution of HIV, HCV, and co-infections among drug users in the southwestern border areas of China (2004-2014): a cohort study of a national methadone maintenance treatment program.

BMC Public Health 2017 09 30;17(1):759. Epub 2017 Sep 30.

Institute of HIV/AIDS Prevention and Control, Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention, 18 Jinzhou Road, Nanning, 530028, Guangxi, People's Republic of China.

Background: A methadone maintenance treatment (MMT) program to curb the dual epidemics of HIV/AIDS and drug use has been administered by China since 2004. Little is known regarding the geographic heterogeneity of HIV and hepatitis C virus (HCV) infections among MMT clients in the resource-constrained context of Chinese provinces, such as Guangxi. This study aimed to characterize the geographic distribution patterns and co-clustered epidemic factors of HIV, HCV and co-infections at the county level among drug users receiving MMT in Guangxi Zhuang Autonomous Region, located in the southwestern border area of China.

Methods: Baseline data on drug users' demographic, behavioral and biological characteristics in the MMT clinics of Guangxi Zhuang Autonomous Region during the period of March 2004 to December 2014 were obtained from national HIV databases. Residential addresses were entered into a geographical information system (GIS) program and analyzed for spatial clustering of HIV, HCV and co-infections among MMT clients at the county level using geographic autocorrelation analysis and geographic scan statistics.

Results: A total of 31,015 MMT clients were analyzed, and the prevalence of HIV, HCV and co-infections were 13.05%, 72.51% and 11.96% respectively. Both the geographic autocorrelation analysis and geographic scan statistics showed that HIV, HCV and co-infections in Guangxi Zhuang Autonomous Region exhibited significant geographic clustering at the county level, and the Moran's I values were 0.33, 0.41 and 0.30, respectively (P < 0.05). The most significant high-risk overlapping clusters for these infections were restricted to within a 10.95 km radius of each of the 13 locations where P county was the cluster center. These infections also co-clustered with certain characteristics, such as being unmarried, having a primary level of education or below, having used drugs for more than 10 years, and receptive sharing of syringes with others. The high-risk clusters for these characteristics were more likely to reside in the areas surrounding P county.

Conclusions: HIV, HCV and co-infections among MMT clients in Guangxi Zhuang Autonomous Region all presented substantial geographic heterogeneity at the county level with a number of overlapping significant clusters. The areas surrounding P county were effective in enrolling high-risk clients in their MMT programs which, in turn, might enable people who inject drugs to inject less, share fewer syringes, and receive referrals for HIV or HCV treatment in a timely manner.
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http://dx.doi.org/10.1186/s12889-017-4769-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622551PMC
September 2017

CdTe Nanocrystal Hetero-Junction Solar Cells with High Open Circuit Voltage Based on Sb-doped TiO₂ Electron Acceptor Materials.

Nanomaterials (Basel) 2017 May 3;7(5). Epub 2017 May 3.

Institute of Polymer Optoelectronic Materials & Devices, State Key Laboratory of Luminescent Materials & Devices, South China University of Technology, Guangzhou 510640, China.

We propose Sb-doped TiO₂ as electron acceptor material for depleted CdTe nanocrystal (NC) hetero-junction solar cells. Novel devices with the architecture of FTO/ZnO/Sb:TiO₂/CdTe/Au based on CdTe NC and TiO₂ precursor are fabricated by rational ambient solution process. By introducing TiO₂ with dopant concentration, we are able to tailor the optoelectronic properties of NC solar cells. Our novel devices demonstrate a very high open circuit voltage of 0.74 V, which is the highest reported for any CdTe NC based solar cells. The power conversion efficiency (PCE) of solar cells increases with the increase of Sb-doped content from 1% to 3%, then decreases almost linearly with further increase of Sb content due to the recombination effect. The champion device shows , , FF, and PCE of 14.65 mA/cm², 0.70 V, 34.44, and 3.53% respectively, which is prospective for solution processed NC solar cells with high .
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http://dx.doi.org/10.3390/nano7050101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449982PMC
May 2017

Declining Inconsistent Condom Use but Increasing HIV and Syphilis Prevalence Among Older Male Clients of Female Sex Workers: Analysis From Sentinel Surveillance Sites (2010-2015), Guangxi, China.

Medicine (Baltimore) 2016 May;95(22):e3726

From the Institute of HIV/AIDS Prevention and Control (YC); Guangxi Center for Disease Control and Prevention (YC, ZS, ZT, GL, QZ, WL, ST, RL, WH, YH, FL, LW), Nanning, China; Vanderbilt Institute for Global Health (SB), Nashville, TN; and State Key Laboratory of Infectious Disease Prevention and Control (YS, YR), National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing, China.

Clients of female sex workers (CFSWs) are a bridge population for the spread of HIV and syphilis to low or average risk heterosexuals. Most studies have examined the point prevalence of these infections in CFSWs. Limited evidence suggests that older age CFSWs are at a higher risk of acquiring sexually transmitted diseases compared with younger clients. Thus, we sought to describe long-term trends in HIV, syphilis, and hepatitis C (HCV) to better understand how these infections differ by sex worker classification and client age. We also examined trends in HIV, syphilis, and HCV among categories of female sex workers (FSWs).We conducted serial cross-sectional studies from 2010 to 2015 in Guangxi autonomous region, China. We collected demographic and behavior variables. FSWs and their clients were tested for HIV, syphilis, and HCV antibodies. Positive HIV and syphilis serologies were confirmed by Western blot and rapid plasma regain, respectively. Clients were categorized as middle age (40-49 years) and older clients (≥50 years). FSWs were categorized as high-tier, middle-tier, or low-tier based on the payment amount charged for sex and their work venue. Chi-square test for trends was used for testing changes in prevalence over time.By 2015, low-tier FSWs (LTFSWs) accounted for almost half of all FSWs; and they had the highest HIV prevalence at 1.4%. HIV prevalence declined significantly for FSWs (high-tier FSW, P = 0.003; middle-tier FSWs; P = 0.021; LTFSWs, P < 0.001). Syphilis infections significantly declined for FSWs (P < 0.001) but only to 7.3% for LTFSWs. HCV and intravenous drug use were uncommon in FSWs. HIV prevalence increased for older age clients (1.3%-2.0%, P = 0.159) while syphilis prevalence remained stable. HCV infections were halved among older clients in 3 years (1.7%-0.8%, P < 0.001). Condom use during the last sexual encounter increased for FSWs and CFSWs. Few clients reported sex with men or intravenous drug use. Clients preferred LTFSWs, especially older clients (81.9%).Our results suggest that HIV and syphilis infections are increasing in older clients who prefer LTFSWs. HIV and syphilis are likely increasing in Guangxi Province through heterosexual transmission.
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http://dx.doi.org/10.1097/MD.0000000000003726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900708PMC
May 2016

Erratum to: Novel Hybrid Ligands for Passivating PbS Colloidal Quantum Dots to Enhance the Performance of Solar Cells.

Nanomicro Lett 2016 16;8(Suppl 1). Epub 2016 Jan 16.

2Siyuan Laboratory, Department of Physics, Jinan University, Guangzhou, 510632 People's Republic of China.

[This corrects the article DOI: 10.1007/s40820-015-0046-4.].
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http://dx.doi.org/10.1007/s40820-015-0078-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223768PMC
January 2016

Novel Hybrid Ligands for Passivating PbS Colloidal Quantum Dots to Enhance the Performance of Solar Cells.

Nanomicro Lett 2015 20;7(4):325-331. Epub 2015 Jun 20.

2Siyuan Laboratory, Department of Physics, Jinan University, Guangzhou, 510632 People's Republic of China.

We developed novel hybrid ligands to passivate PbS colloidal quantum dots (CQDs), and two kinds of solar cells based on as-synthesized CQDs were fabricated to verify the passivation effects of the ligands. It was found that the ligands strongly affected the optical and electrical properties of CQDs, and the performances of solar cells were enhanced strongly. The optimized hybrid ligands, oleic amine/octyl-phosphine acid/CdCl improved power conversion efficiency (PCE) to much higher of 3.72 % for Schottky diode cell and 5.04 % for p-n junction cell. These results may be beneficial to design passivation strategy for low-cost and high-performance CQDs solar cells.
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http://dx.doi.org/10.1007/s40820-015-0046-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223900PMC
June 2015
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