Wen-Lang Lin

Wen-Lang Lin

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Wen-Lang Lin

Wen-Lang Lin

Publications by authors named "Wen-Lang Lin"

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Tangential Flow Filtration for Highly Efficient Concentration of Extracellular Vesicles from Large Volumes of Fluid.

Cells 2018 Dec 16;7(12). Epub 2018 Dec 16.

Department of Transplantation Medicine; Department of Physiology and Biomedical Engineering, Mayo Clinic, Jacksonville, FL 32224, USA.

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http://dx.doi.org/10.3390/cells7120273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315734PMC
December 2018

p62 Pathology Model in the Rat Substantia Nigra with Filamentous Inclusions and Progressive Neurodegeneration.

PLoS One 2017 11;12(1):e0169291. Epub 2017 Jan 11.

Department of Pharmacology, Toxicology, and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, LA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0169291PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226781PMC
August 2017

Perry Syndrome: A Distinctive Type of TDP-43 Proteinopathy.

J Neuropathol Exp Neurol 2017 Aug;76(8):676-682

Department of Neuroscience, Mayo Clinic, Jacksonville, Florida (TM, SK, W-LL, KK, MC-C, DWD); Department of Neurology, Fukuoka University, Fukuoka, Japan (TM, YT); Department of Neurology, Mayo Clinic, Jacksonville, Florida (ZKW); and Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama (SJO).

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http://dx.doi.org/10.1093/jnen/nlx049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901076PMC
August 2017

A Novel Tau Mutation in Exon 12, p.Q336H, Causes Hereditary Pick Disease.

J Neuropathol Exp Neurol 2015 Nov;74(11):1042-52

From the Departments of Neurology (PT, ZKW), Neuroscience (MD, KMH, W-LL, MS-C, YC, RR, OAR, DWD), and Psychiatry and Psychology (OP), Mayo Clinic Florida, Jacksonville, Florida.

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http://dx.doi.org/10.1097/NEN.0000000000000248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607649PMC
November 2015

ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function.

Neuron 2015 Nov 29;88(4):678-90. Epub 2015 Oct 29.

Tanz Centre for Research in Neurodegenerative Diseases, and Departments of Medicine, Medical Biophysics and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 3H2, Canada; Cambridge Institute for Medical Research, Cambridge National Institute for Health Research - Biomedical Research Unit in Dementia, University of Cambridge, Cambridge CB2 0XY, UK. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2015.10.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660210PMC
November 2015

Nutrient deprivation induces α-synuclein aggregation through endoplasmic reticulum stress response and SREBP2 pathway.

Front Aging Neurosci 2014 8;6:268. Epub 2014 Oct 8.

Department of Neuroscience, Mayo Clinic College of Medicine Jacksonville, FL, USA.

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http://dx.doi.org/10.3389/fnagi.2014.00268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189422PMC
October 2014

Optineurin immunoreactivity in neuronal and glial intranuclear inclusions in adult-onset neuronal intranuclear inclusion disease.

Am J Neurodegener Dis 2014 6;3(2):93-102. Epub 2014 Sep 6.

Department of Neuroscience, Mayo Clinic 4500 San Pablo Road, Jacksonville, FL 32224, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162590PMC
September 2014

Endogenous tau aggregates in oligodendrocytes of rTg4510 mice induced by human P301L tau.

J Alzheimers Dis 2014 ;38(3):589-600

Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, Gainesville, FL, USA.

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http://dx.doi.org/10.3233/JAD-130986DOI Listing
July 2014

Clinicopathologic assessment and imaging of tauopathies in neurodegenerative dementias.

Alzheimers Res Ther 2014 2;6(1). Epub 2014 Jan 2.

Department of Radiology, Mayo Clinic, 200 1st St, SW Rochester, MN 55905, USA.

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http://dx.doi.org/10.1186/alzrt231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978456PMC
June 2014

Age-related decline in white matter integrity in a mouse model of tauopathy: an in vivo diffusion tensor magnetic resonance imaging study.

Neurobiol Aging 2014 Jun 19;35(6):1364-74. Epub 2013 Dec 19.

Department of Psychiatry, University of Florida, Gainesville, FL, USA; Department of Neuroscience, University of Florida, Gainesville, FL, USA; Evelyn F. and William L. McKnight Brain Institute, University of Florida, Gainesville, FL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2013.12.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729397PMC
June 2014

ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43.

Nat Commun 2014 Jun 3;5:3996. Epub 2014 Jun 3.

1] Department of Neuroscience, Institute of Psychiatry, Kings College London, London SE5 8AF, UK [2] Clinical Neurosciences, Institute of Psychiatry, Kings College London, London SE5 8AF, UK.

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http://dx.doi.org/10.1038/ncomms4996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046113PMC
June 2014

The ALS disease-associated mutant TDP-43 impairs mitochondrial dynamics and function in motor neurons.

Hum Mol Genet 2013 Dec 4;22(23):4706-19. Epub 2013 Jul 4.

Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1093/hmg/ddt319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820133PMC
December 2013

Diversity of pathological features other than Lewy bodies in familial Parkinson's disease due to SNCA mutations.

Am J Neurodegener Dis 2013 29;2(4):266-75. Epub 2013 Nov 29.

Departments of Neuroscience, Mayo Clinic Jacksonville, FL, USA ; Current address: Hiroshige Fujishiro, Juntendo University School of Medicine Tokyo, Japan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852566PMC
December 2013

Robust cytoplasmic accumulation of phosphorylated TDP-43 in transgenic models of tauopathy.

Acta Neuropathol 2013 Jul 11;126(1):39-50. Epub 2013 May 11.

Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, McKnight Brain Institute, University of Florida, 1275 Center Drive, BMS Building J-483, PO Box 100159, Gainesville, FL 32610-0244, USA.

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http://dx.doi.org/10.1007/s00401-013-1123-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690181PMC
July 2013

Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice.

Mol Neurodegener 2011 Oct 26;6:73. Epub 2011 Oct 26.

Department of Neuroscience, Mayo Clinic, Jacksonville, 32224, USA.

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http://dx.doi.org/10.1186/1750-1326-6-73DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216869PMC
October 2011

Immunoelectron microscopic and biochemical studies of caspase-cleaved tau in a mouse model of tauopathy.

J Neuropathol Exp Neurol 2011 Sep;70(9):779-87

Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida, USA.

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http://dx.doi.org/10.1097/NEN.0b013e31822ac9c9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162471PMC
September 2011

Interferon-γ induces progressive nigrostriatal degeneration and basal ganglia calcification.

Nat Neurosci 2011 Jun 15;14(6):694-6. Epub 2011 May 15.

Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, Gainesville, Florida, USA.

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http://www.nature.com/articles/nn.2829
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http://dx.doi.org/10.1038/nn.2829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3780582PMC
June 2011

ER stress response plays an important role in aggregation of α-synuclein.

Mol Neurodegener 2010 Dec 13;5:56. Epub 2010 Dec 13.

Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, Florida 32224, USA.

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http://molecularneurodegeneration.biomedcentral.com/articles
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http://dx.doi.org/10.1186/1750-1326-5-56DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016345PMC
December 2010

Hereditary diffuse leukoencephalopathy with spheroids: ultrastructural and immunoelectron microscopic studies.

Int J Clin Exp Pathol 2010 Jul 26;3(7):665-74. Epub 2010 Jul 26.

Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933386PMC
July 2010

Transactivation response DNA-binding protein 43 microvasculopathy in frontotemporal degeneration and familial Lewy body disease.

J Neuropathol Exp Neurol 2009 Nov;68(11):1167-76

Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida 32224, USA.

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http://dx.doi.org/10.1097/NEN.0b013e3181baacecDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783428PMC
November 2009

Overexpression of wild-type murine tau results in progressive tauopathy and neurodegeneration.

Am J Pathol 2009 Oct 28;175(4):1598-609. Epub 2009 Aug 28.

Department of Neuroscience, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, FL 32224, USA.

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http://dx.doi.org/10.2353/ajpath.2009.090462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751556PMC
October 2009

Aggregates assembled from overexpression of wild-type alpha-synuclein are not toxic to human neuronal cells.

J Neuropathol Exp Neurol 2008 Nov;67(11):1084-96

Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida 32224, USA.

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http://dx.doi.org/10.1097/NEN.0b013e31818c3618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768257PMC
November 2008

Frontotemporal lobar degeneration with ubiquitin-positive, but TDP-43-negative inclusions.

Acta Neuropathol 2008 Aug 14;116(2):159-67. Epub 2008 Jun 14.

Department of Neurology, Mayo Clinic, Rochester, MN, USA.

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http://dx.doi.org/10.1007/s00401-008-0397-8DOI Listing
August 2008

Ultrastructural localization of TDP-43 in filamentous neuronal inclusions in various neurodegenerative diseases.

Acta Neuropathol 2008 Aug 8;116(2):205-13. Epub 2008 Jul 8.

Department of Neuroscience, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

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http://dx.doi.org/10.1007/s00401-008-0408-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2706695PMC
August 2008

Co-localization of tau and alpha-synuclein in the olfactory bulb in Alzheimer's disease with amygdala Lewy bodies.

Acta Neuropathol 2008 Jul 30;116(1):17-24. Epub 2008 Apr 30.

Department of Neuroscience, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

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http://dx.doi.org/10.1007/s00401-008-0383-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719249PMC
July 2008

Autophagic-lysosomal perturbation enhances tau aggregation in transfectants with induced wild-type tau expression.

Eur J Neurosci 2008 Mar 22;27(5):1119-30. Epub 2008 Feb 22.

Department of Neuroscience, Mayo Clinic Jacksonville, Jacksonville, FL, USA.

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http://dx.doi.org/10.1111/j.1460-9568.2008.06084.xDOI Listing
March 2008

Neurofibrillary tangle-related synaptic alterations of spinal motor neurons of P301L tau transgenic mice.

Neurosci Lett 2006 Dec 28;409(2):95-9. Epub 2006 Sep 28.

Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S030439400600960
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http://dx.doi.org/10.1016/j.neulet.2006.09.021DOI Listing
December 2006

Heterogeneous inclusions in neurofilament inclusion disease.

Neuropathology 2006 Oct;26(5):417-21

Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224, USA.

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October 2006

Alzheimer disease with amygdala Lewy bodies: a distinct form of alpha-synucleinopathy.

J Neuropathol Exp Neurol 2006 Jul;65(7):685-97

Department of Pathology, Mayo Clinic College of Medicine, Jacksonville, Florida 32224, USA.

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http://dx.doi.org/10.1097/01.jnen.0000225908.90052.07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706655PMC
July 2006

Progressive white matter pathology in the spinal cord of transgenic mice expressing mutant (P301L) human tau.

J Neurocytol 2005 Dec 10;34(6):397-410. Epub 2006 Aug 10.

Mayo Clinic College of Medicine, Jacksonville, Florida, 32224, USA.

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http://dx.doi.org/10.1007/s11068-006-8726-0DOI Listing
December 2005

Tau gene transfer, but not alpha-synuclein, induces both progressive dopamine neuron degeneration and rotational behavior in the rat.

Neurobiol Dis 2005 Oct;20(1):64-73

Department of Pharmacology and Therapeutics, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA.

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http://dx.doi.org/10.1016/j.nbd.2005.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2975329PMC
October 2005

Raft-like membrane domains contain enzymatic activities involved in the synthesis of mammalian glycosylphosphatidylinositol anchor intermediates.

Biochem Biophys Res Commun 2005 Apr;330(1):163-71

Department of Neuroscience, Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA.

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http://dx.doi.org/10.1016/j.bbrc.2005.02.136DOI Listing
April 2005

Assembly of filamentous tau aggregates in human neuronal cells.

J Alzheimers Dis 2004 Dec;6(6):605-22; discussion 673-81

Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, FL 32224, USA.

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December 2004

Rapid neurofibrillary tangle formation after localized gene transfer of mutated tau.

Am J Pathol 2004 Jan;164(1):347-53

Department of Pharmacology and Therapeutics, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1602230PMC
http://dx.doi.org/10.1016/S0002-9440(10)63124-0DOI Listing
January 2004

Alpha-synuclein immunoreactivity in neuronal nuclear inclusions and neurites in multiple system atrophy.

Neurosci Lett 2004 Jan;354(2):99-102

Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA.

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http://dx.doi.org/10.1016/j.neulet.2003.09.075DOI Listing
January 2004