Publications by authors named "Wen-Bin Yue"

8 Publications

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Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations.

Authors:
Chen Wu Zhaoming Wang Xin Song Xiao-Shan Feng Christian C Abnet Jie He Nan Hu Xian-Bo Zuo Wen Tan Qimin Zhan Zhibin Hu Zhonghu He Weihua Jia Yifeng Zhou Kai Yu Xiao-Ou Shu Jian-Min Yuan Wei Zheng Xue-Ke Zhao She-Gan Gao Zhi-Qing Yuan Fu-You Zhou Zong-Min Fan Ji-Li Cui Hong-Li Lin Xue-Na Han Bei Li Xi Chen Sanford M Dawsey Linda Liao Maxwell P Lee Ti Ding You-Lin Qiao Zhihua Liu Yu Liu Dianke Yu Jiang Chang Lixuan Wei Yu-Tang Gao Woon-Puay Koh Yong-Bing Xiang Ze-Zhong Tang Jin-Hu Fan Jing-Jing Han Sheng-Li Zhou Peng Zhang Dong-Yun Zhang Yuan Yuan Ying Huang Chunling Liu Kan Zhai Yan Qiao Guangfu Jin Chuanhai Guo Jianhua Fu Xiaoping Miao Changdong Lu Haijun Yang Chaoyu Wang William A Wheeler Mitchell Gail Meredith Yeager Jeff Yuenger Er-Tao Guo Ai-Li Li Wei Zhang Xue-Min Li Liang-Dan Sun Bao-Gen Ma Yan Li Sa Tang Xiu-Qing Peng Jing Liu Amy Hutchinson Kevin Jacobs Carol Giffen Laurie Burdette Joseph F Fraumeni Hongbing Shen Yang Ke Yixin Zeng Tangchun Wu Peter Kraft Charles C Chung Margaret A Tucker Zhi-Chao Hou Ya-Li Liu Yan-Long Hu Yu Liu Li Wang Guo Yuan Li-Sha Chen Xiao Liu Teng Ma Hui Meng Li Sun Xin-Min Li Xiu-Min Li Jian-Wei Ku Ying-Fa Zhou Liu-Qin Yang Zhou Wang Yin Li Qirenwang Qige Wen-Jun Yang Guang-Yan Lei Long-Qi Chen En-Min Li Ling Yuan Wen-Bin Yue Ran Wang Lu-Wen Wang Xue-Ping Fan Fang-Heng Zhu Wei-Xing Zhao Yi-Min Mao Mei Zhang Guo-Lan Xing Ji-Lin Li Min Han Jing-Li Ren Bin Liu Shu-Wei Ren Qing-Peng Kong Feng Li Ilyar Sheyhidin Wu Wei Yan-Rui Zhang Chang-Wei Feng Jin Wang Yu-Hua Yang Hong-Zhang Hao Qi-De Bao Bao-Chi Liu Ai-Qun Wu Dong Xie Wan-Cai Yang Liang Wang Xiao-Hang Zhao Shu-Qing Chen Jun-Yan Hong Xue-Jun Zhang Neal D Freedman Alisa M Goldstein Dongxin Lin Philip R Taylor Li-Dong Wang Stephen J Chanock

Nat Genet 2014 Sep 17;46(9):1001-1006. Epub 2014 Aug 17.

Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA.

We conducted a joint (pooled) analysis of three genome-wide association studies (GWAS) of esophageal squamous cell carcinoma (ESCC) in individuals of Chinese ancestry (5,337 ESCC cases and 5,787 controls) with 9,654 ESCC cases and 10,058 controls for follow-up. In a logistic regression model adjusted for age, sex, study and two eigenvectors, two new loci achieved genome-wide significance, marked by rs7447927 at 5q31.2 (per-allele odds ratio (OR) = 0.85, 95% confidence interval (CI) = 0.82-0.88; P = 7.72 × 10(-20)) and rs1642764 at 17p13.1 (per-allele OR = 0.88, 95% CI = 0.85-0.91; P = 3.10 × 10(-13)). rs7447927 is a synonymous SNP in TMEM173, and rs1642764 is an intronic SNP in ATP1B2, near TP53. Furthermore, a locus in the HLA class II region at 6p21.32 (rs35597309) achieved genome-wide significance in the two populations at highest risk for ESSC (OR = 1.33, 95% CI = 1.22-1.46; P = 1.99 × 10(-10)). Our joint analysis identifies new ESCC susceptibility loci overall as well as a new locus unique to the population in the Taihang Mountain region at high risk of ESCC.
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http://dx.doi.org/10.1038/ng.3064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212832PMC
September 2014

Variations in the MHC region confer risk to esophageal squamous cell carcinoma on the subjects from high-incidence area in northern China.

PLoS One 2014 4;9(3):e90438. Epub 2014 Mar 4.

Henan Key Laboratory for Esophageal Cancer Research of the First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.

Background: The human major histocompatibility complex (MHC) is the most important region in vertebrate genome, and is crucial in innate immunity. Recent studies have demonstrated the possible role of polymorphisms in the MHC region to high risk for esophageal squamous cell carcinoma (ESCC). Our previous genome-wide association study (GWAS) has indicated that the MHC region may confer important risk loci for ESCC, but without further fine mapping. The aim of this study is to further identify the risk loci in the MHC region for ESCC in Chinese population.

Methods: Conditional logistic regression analysis (CLRA) was performed on 24 single nucleotide polymorphisms (SNPs) within the MHC region, which were obtained from the genetically matched 937 cases and 692 controls of Chinese Han population. The identified promising SNPs were further correlated with clinical and clinicopathology characteristics. Immunohistochemistry was performed to explore the protein expression pattern of the related genes in ESCC and neighboring normal tissues.

Results: Of the 24 promising SNPs analyzed, we identified three independent SNPs in the MHC region associated with ESCC: rs35399661 (P = 6.07E-06, OR = 1.71, 95%CI = 1.36-2.17), rs3763338 (P = 1.62E-05, OR = 0.63, 95%CI = 0.50-0.78) and rs2844695 (P = 7.60E-05, OR = 0.74, 95%CI = 0.64-0.86). These three SNPs were located at the genes of HLA-DQA1, TRIM27, and DPCR1, respectively. Further analyses showed that rs2844695 was preferentially associated with younger ESCC cases (P = 0.009). The positive immunostaining rates both for HLA-DQA1 and TRIM27 were much higher in ESCC tissues than in neighboring normal tissues (69.4% vs. 26.8% for HLA-DQA1 and 77.6% vs. 47.8% for TRIM27, P<0.001). Furthermore, the overexpression of HLA-DQA1 is correlated significantly with age (P = 0.001) and family history (P<0.001).

Conclusion: This study for the first time provides evidence that multiple genetic factors within the MHC region confer risk to ESCC on the subjects from high-risk area in northern China.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0090438PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942432PMC
February 2015

Genotypic variants at 2q33 and risk of esophageal squamous cell carcinoma in China: a meta-analysis of genome-wide association studies.

Authors:
Christian C Abnet Zhaoming Wang Xin Song Nan Hu Fu-You Zhou Neal D Freedman Xue-Min Li Kai Yu Xiao-Ou Shu Jian-Min Yuan Wei Zheng Sanford M Dawsey Linda M Liao Maxwell P Lee Ti Ding You-Lin Qiao Yu-Tang Gao Woon-Puay Koh Yong-Bing Xiang Ze-Zhong Tang Jin-Hu Fan Charles C Chung Chaoyu Wang William Wheeler Meredith Yeager Jeff Yuenger Amy Hutchinson Kevin B Jacobs Carol A Giffen Laurie Burdett Joseph F Fraumeni Margaret A Tucker Wong-Ho Chow Xue-Ke Zhao Jiang-Man Li Ai-Li Li Liang-Dan Sun Wu Wei Ji-Lin Li Peng Zhang Hong-Lei Li Wen-Yan Cui Wei-Peng Wang Zhi-Cai Liu Xia Yang Wen-Jing Fu Ji-Li Cui Hong-Li Lin Wen-Liang Zhu Min Liu Xi Chen Jie Chen Li Guo Jing-Jing Han Sheng-Li Zhou Jia Huang Yue Wu Chao Yuan Jing Huang Ai-Fang Ji Jian-Wei Kul Zhong-Min Fan Jian-Po Wang Dong-Yun Zhang Lian-Qun Zhang Wei Zhang Yuan-Fang Chen Jing-Li Ren Xiu-Min Li Jin-Cheng Dong Guo-Lan Xing Zhi-Gang Guo Jian-Xue Yang Yi-Ming Mao Yuan Yuan Er-Tao Guo Wei Zhang Zhi-Chao Hou Jing Liu Yan Li Sa Tang Jia Chang Xiu-Qin Peng Min Han Wan-Li Yin Ya-Li Liu Yan-Long Hu Yu Liu Liu-Qin Yang Fu-Guo Zhu Xiu-Feng Yang Xiao-Shan Feng Zhou Wang Yin Li She-Gan Gao Hai-Lin Liu Ling Yuan Yan Jin Yan-Rui Zhang Ilyar Sheyhidin Feng Li Bao-Ping Chen Shu-Wei Ren Bin Liu Dan Li Gao-Fu Zhang Wen-Bin Yue Chang-Wei Feng Qirenwang Qige Jian-Ting Zhao Wen-Jun Yang Guang-Yan Lei Long-Qi Chen En-Min Li Li-Yan Xu Zhi-Yong Wu Zhi-Qin Bao Ji-Li Chen Xian-Chang Li Xiang Zhuang Ying-Fa Zhou Xian-Bo Zuo Zi-Ming Dong Lu-Wen Wang Xue-Pin Fan Jin Wang Qi Zhou Guo-Shun Ma Qin-Xian Zhang Hai Liu Xin-Ying Jian Sin-Yong Lian Jin-Sheng Wang Fu-Bao Chang Chang-Dong Lu Jian-Jun Miao Zhi-Guo Chen Ran Wang Ming Guo Zeng-Lin Fan Ping Tao Tai-Jing Liu Jin-Chang Wei Qing-Peng Kong Lei Fan Xian-Zeng Wang Fu-Sheng Gao Tian-Yun Wang Dong Xie Li Wang Shu-Qing Chen Wan-Cai Yang Jun-Yan Hong Liang Wang Song-Liang Qiu Alisa M Goldstein Zhi-Qing Yuan Stephen J Chanock Xue-Jun Zhang Philip R Taylor Li-Dong Wang

Hum Mol Genet 2012 May 8;21(9):2132-41. Epub 2012 Feb 8.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-7236, USA.

Genome-wide association studies have identified susceptibility loci for esophageal squamous cell carcinoma (ESCC). We conducted a meta-analysis of all single-nucleotide polymorphisms (SNPs) that showed nominally significant P-values in two previously published genome-wide scans that included a total of 2961 ESCC cases and 3400 controls. The meta-analysis revealed five SNPs at 2q33 with P< 5 × 10(-8), and the strongest signal was rs13016963, with a combined odds ratio (95% confidence interval) of 1.29 (1.19-1.40) and P= 7.63 × 10(-10). An imputation analysis of 4304 SNPs at 2q33 suggested a single association signal, and the strongest imputed SNP associations were similar to those from the genotyped SNPs. We conducted an ancestral recombination graph analysis with 53 SNPs to identify one or more haplotypes that harbor the variants directly responsible for the detected association signal. This showed that the five SNPs exist in a single haplotype along with 45 imputed SNPs in strong linkage disequilibrium, and the strongest candidate was rs10201587, one of the genotyped SNPs. Our meta-analysis found genome-wide significant SNPs at 2q33 that map to the CASP8/ALS2CR12/TRAK2 gene region. Variants in CASP8 have been extensively studied across a spectrum of cancers with mixed results. The locus we identified appears to be distinct from the widely studied rs3834129 and rs1045485 SNPs in CASP8. Future studies of esophageal and other cancers should focus on comprehensive sequencing of this 2q33 locus and functional analysis of rs13016963 and rs10201587 and other strongly correlated variants.
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http://dx.doi.org/10.1093/hmg/dds029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315211PMC
May 2012

Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54.

Authors:
Li-Dong Wang Fu-You Zhou Xue-Min Li Liang-Dan Sun Xin Song Yan Jin Jiang-Man Li Guo-Qiang Kong Hong Qi Juan Cui Lian-Qun Zhang Jie-Zhi Yang Ji-Lin Li Xing-Chuan Li Jing-Li Ren Zhi-Cai Liu Wen-Jun Gao Ling Yuan Wu Wei Yan-Rui Zhang Wei-Peng Wang Ilyar Sheyhidin Feng Li Bao-Ping Chen Shu-Wei Ren Bin Liu Dan Li Jian-Wei Ku Zong-Min Fan Sheng-Li Zhou Zhi-Gang Guo Xue-Ke Zhao Na Liu Yong-Hong Ai Fang-Fang Shen Wen-Yan Cui Shuang Song Tao Guo Jing Huang Chao Yuan Jia Huang Yue Wu Wen-Bin Yue Chang-Wei Feng Hong-Lei Li Yan Wang Jin-Ya Tian Yue Lu Yi Yuan Wen-Liang Zhu Min Liu Wen-Jing Fu Xia Yang Han-Jing Wang Suo-Li Han Jie Chen Min Han Hai-Yan Wang Peng Zhang Xiu-Min Li Jin-Cheng Dong Guo-Lan Xing Ran Wang Ming Guo Zhi-Wei Chang Hai-Lin Liu Li Guo Zhi-Qing Yuan Hai Liu Qin Lu Liu-Qin Yang Fu-Guo Zhu Xiu-Feng Yang Xiao-Shan Feng Zhou Wang Yin Li She-Gan Gao Qirenwang Qige Long-Tang Bai Wen-Jun Yang Guang-Yan Lei Zhong-Ying Shen Long-Qi Chen En-Min Li Li-Yan Xu Zhi-Yong Wu Wei-Ke Cao Jian-Po Wang Zhi-Qin Bao Ji-Li Chen Guang-Cheng Ding Xiang Zhuang Ying-Fa Zhou Hou-Feng Zheng Zheng Zhang Xian-Bo Zuo Zi-Ming Dong Dong-Mei Fan Xin He Jin Wang Qi Zhou Qin-Xian Zhang Xin-Ying Jiao Shi-Yong Lian Ai-Fang Ji Xiao-Mei Lu Jin-Sheng Wang Fu-Bao Chang Chang-Dong Lu Zhi-Guo Chen Jian-Jun Miao Zeng-Lin Fan Ruo-Bai Lin Tai-Jiang Liu Jin-Chang Wei Qing-Peng Kong Yu Lan Yu-Jing Fan Fu-Sheng Gao Tian-Yun Wang Dong Xie Shu-Qing Chen Wan-Cai Yang Jun-Yan Hong Liang Wang Song-Liang Qiu Zhi-Ming Cai Xue-Jun Zhang

Nat Genet 2010 Sep 22;42(9):759-63. Epub 2010 Aug 22.

Cancer Research Center, Xinxiang Medical University, Xinxiang, Henan, China.

We performed a genome-wide association study of esophageal squamous cell carcinoma (ESCC) by genotyping 1,077 individuals with ESCC and 1,733 control subjects of Chinese Han descent. We selected 18 promising SNPs for replication in an additional 7,673 cases of ESCC and 11,013 control subjects of Chinese Han descent and 303 cases of ESCC and 537 control subjects of Chinese Uygur-Kazakh descent. We identified two previously unknown susceptibility loci for ESCC: PLCE1 at 10q23 (P(Han combined for ESCC) = 7.46 x 10(-56), odds ratio (OR) = 1.43; P(Uygur-Kazakh for ESCC) = 5.70 x 10(-4), OR = 1.53) and C20orf54 at 20p13 (P(Han combined for ESCC) = 1.21 x 10(-11), OR = 0.86; P(Uygur-Kazakh for ESCC) = 7.88 x 10(-3), OR = 0.66). We also confirmed association in 2,766 cases of gastric cardia adenocarcinoma cases and the same 11,013 control subjects (PLCE1, P(Han for GCA) = 1.74 x 10(-39), OR = 1.55 and C20orf54, P(Han for GCA) = 3.02 x 10(-3), OR = 0.91). PLCE1 and C20orf54 have important biological implications for both ESCC and GCA. PLCE1 might regulate cell growth, differentiation, apoptosis and angiogenesis. C20orf54 is responsible for transporting riboflavin, and deficiency of riboflavin has been documented as a risk factor for ESCC and GCA.
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http://dx.doi.org/10.1038/ng.648DOI Listing
September 2010

[Applications of near infrared reflectance spectroscopy technique to determination of forage mycotoxins].

Guang Pu Xue Yu Guang Pu Fen Xi 2010 May;30(5):1243-7

College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu 030801, China.

The near infrared reflectance spectroscopy technique (NIRS) has been explored at many fields such as agriculture, food, chemical, medicine, and so on, due to its rapid, effective, non-destructive, and on-line characteristics. Fungi invasion in forage materials during processing and storage would generate mycotoxins, which were harmful for people and animal through food chains. The determination of mycotoxins included the overelaborated pretreatments such as milling, extracting, chromatography and subsequent process such as enzyme linked immunosorbent assay, high performance liquid chromatography, and thin layer chromatography. The authors hope that high precision and low detection limit spectrum instrument, and software technology and calibration model of mycotoxins determination, will fast measure accurately the quality and quantity of mycotoxins, which will provide basis for reasonable process and utilization of forage and promote the application of NIRS in the safety livestock product.
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May 2010

Cloning, characterization, and expression analysis of goat (Capra hircus) phospholipid hydroperoxide glutathione peroxidase (PHGPx).

Int J Biol Sci 2010 Jun 10;6(4):316-26. Epub 2010 Jun 10.

College of Animal Science and Veterinary Medicines, Shanxi Agricultural University, Taigu, Shanxi 030801, China.

Phospholipid hydroperoxide glutathione peroxidase (PHGPx), as a ubiquitous antioxidant enzyme in the glutathione peroxidases (GPx) family, plays multiple roles in organisms. However, there is very little information on PHGPx in goats (Capra hircus). In this study, a full-length cDNA was cloned and characterized from Taihang black goat testes. The 844 bp cDNA contains an open reading frame (ORF) of 597 bp. The goat PHGPx nucleotide sequence contains a selenocysteine (sec) codon TGA(244-246), two potential start codons ATG(20-22) and ATG(108-110), a polyadenylation signal AATAAA(813-818) and selenocysteine insertion sequence (SECIS) motif AUGA(688-691), UGA(729-731) and AAA(703-705). As a selenoprotein, the active-site motifs and GPx family signature motifs LAFPCNQF(101-108) and WNFEK(165-170) were also found. The order of PHGPx mRNA expression levels was: testes > heart > brain > epididymis > kidney > liver > lung > spleen > muscle. Real-time PCR and immunohistochemistry results revealed similar expression differences in different age testes, with high expression levels during adolescence. Immunofluorescence results suggested that PHGPx mainly expressed in Leydig cells and spermatids in mature goat testes.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892295PMC
http://dx.doi.org/10.7150/ijbs.6.316DOI Listing
June 2010

Effect of elemental nano-selenium on semen quality, glutathione peroxidase activity, and testis ultrastructure in male Boer goats.

Anim Reprod Sci 2010 Apr 23;118(2-4):248-54. Epub 2009 Oct 23.

College of Animal Science and Veterinary Medicines, Shanxi Agricultural University, Taigu, Shanxi 030801, China.

The objective of this experiment is to study the effects of novel elemental nano-selenium in the diet on testicular ultrastructure, semen quality and GSH-Px activity in male goats. Forty-two 2-month-old bucks were offered a total mixed ration which had been supplemented with nano-Se (0.3mg/kg Se) or unsupplemented (the control group only received 0.06mg/kg Se-background), for a period of 12 weeks (from weaning to sexual maturity). Results showed that the testicular Se level, semen glutathione peroxidase and ATPase activity increased significantly in the nano-Se supplementation group compared with control (P<0.05). The semen quality (volume, density, motility and pH) was not affected by added Se in diets, however, the sperm abnormality rate of control bucks was significantly higher than Se supplemented bucks (P<0.05). The testes of 5 goats in each group were examined by transmission electron microscopy (TEM), and showed that in Se-deficient bucks the membrane was damaged, and showed the occurrence of abnormalities in the mitochondria of the midpiece of spermatozoa. In conclusion, selenium deficiency resulted in abnormal spermatozoal mitochondria, and supplementation with nano-Se enhanced the testis Se content, testicular and semen GSH-Px activity, protected the membrane system integrity and the tight arrayment of the midpiece of the mitochondria. Further studies are required to research the novel elemental nano-Se with characterization of bioavailability and toxicity in small ruminants.
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http://dx.doi.org/10.1016/j.anireprosci.2009.10.003DOI Listing
April 2010

[Relationship between genotypes at MyoD locus and carcass traits in cattle].

Yi Chuan 2007 Mar;29(3):313-8

Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China.

A 261 bp sequence of the bovine MyoD gene intron 2 was cloned and was found to bear no similarities to the human MyoD gene sequence. Polymorphisms of the Myod gene in cattle including three Chinese breeds (Luxi cattle, Jinnan cattle and Qinchuan cattle) and four cross-breeding populations (Limousin x Luxi cattle, Simmental x Luxi cattle, Charolais x Luxi cattle and Angus x Luxi cattle) were detected by PCR-SSCP. Two SSCP alleles (A and B) were detected, which caused by a C-->T at 39 bp and a C-->G transition at 112 bp. Only two genotypes AA and AB occurred in the population. In Chinese local cattle, B allele was dominant, and this locus was at Hardy-Weinberg equilibrium except for the Charolais x Luxi cattle and Angus x Luxi cattle. The association of these polymorphisms with cattle carcass traits was analyzed using the general linear model (GLM). Statistical analysis revealed a higher value of living weight, carcass weight and loin eye area for individuals with genotype AA than AB (P < 0.05). Further studies on a bigger population size are needed to confirm the observed effect of MyoD genotypes on carcass quality traits.
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http://dx.doi.org/10.1360/yc-007-0313DOI Listing
March 2007