Publications by authors named "Wen Sun"

511 Publications

Mussel-inspired superhydrophilic membrane constructed on a hydrophilic polymer network for highly efficient oil/water separation.

J Colloid Interface Sci 2021 Sep 29;608(Pt 1):702-710. Epub 2021 Sep 29.

Department of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta T6G 1H9, Canada. Electronic address:

Hypothesis: Superhydrophilic/underwater superoleophobic membrane constructed by hydrophilic polymers possesses great advantage in the separation of oily waste water, due to its intrinsic oil-repellent property. The formation of hydration layer to repel and block oil is considered as the mechanism of underwater superoleophobicity and subsequent oil/water separation. Constructing a stable hydrophilic polymer network on the substrate surface would significantly improve the robustness of hydration layer.

Experiments: In this work, a feasible and universal mussel-inspired dip-coating method was developed for constructing stable hydrophilic polymer network onto target substrate surface, via successively immersing substrate membranes into aqueous solutions of polydopamine (PDA) and catechol-functionalized hydrophilic polymer (CFHP). After pre-wetting with water, the polymer network would swell with water to form a thin and stable water film layer, serving as a barrier against oil penetration.

Findings: The as-prepared CFHP/PDA modified membranes exhibit outstanding performance in separating various oil/water mixtures and oil-in-water emulsions stabilized by surfactants, with separation flux up to 5641.1 L·m·h and separation efficiency achieving 99.98%. The surface modification method developed in this work can be easily extended to various materials and membrane systems, for achieving a variety of practical applications such as industrial wastewater treatment.
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http://dx.doi.org/10.1016/j.jcis.2021.09.123DOI Listing
September 2021

Cancer immunogenic cell death via photo-pyroptosis with light-sensitive Indoleamine 2,3-dioxygenase inhibitor conjugate.

Biomaterials 2021 Sep 30;278:121167. Epub 2021 Sep 30.

State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, Dalian, 116024, PR China; State Key Laboratory of Fine Chemicals, Shenzhen Research Institute, Dalian University of Technology, Nanshan District, Shenzhen, 518057, PR China. Electronic address:

Immune checkpoint blockade (ICB) therapy currently considered as to be effective way to cure cancer in clinic. However, the insufficient tumor immunogenicity and the immunosuppressive tumor microenvironment always result in diminished efficacy of immunotherapy. Herein, we report the synthesis of an organic photo-immune activator NBS-1MT, the combination of photosensitizer and Indoleamine 2,3-dioxygenase (IDO) inhibitor effectively stimulates lysosomes oxidative stress the releases inflammatory cytokines. This process triggers pyroptosis for the considerable immunogenic cell death (ICD) while reversing suppressive tumor microenvironment. The photo-immune drug shows outstanding potential to activate caspase-1and then remove gasdermin-D (GSDMD), which could stimulate pyroptosis and also inhibit the tumor growth successfully in both primary and distant tumor. Furthermore, pyroptosis activated by photodynamic therapy (PDT) promotes the immune related factors release, and enhance the intratumoral infiltration of cytotoxic T lymphocytes (CTLs) with the induction of ICD of tumor cells and the cascaded synergize with IDO inhibitor, so the general antitumor immune response could be strengthened effectively. Our research confirms that the use of NBS-1MT is a promising strategy to boost the immune response and eventually to inhibit tumor growth.
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http://dx.doi.org/10.1016/j.biomaterials.2021.121167DOI Listing
September 2021

Evaluation of the etiology and risk factors for maternal sepsis: A single center study in Guangzhou, China.

World J Clin Cases 2021 Sep;9(26):7704-7716

Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, Guangdong Province, China.

Background: Maternal sepsis is a major cause of gestational morbidity and neonatal mortality worldwide and particularly in China.

Aim: To evaluate the etiology of maternal sepsis and further identify its risk factors.

Methods: In this retrospective study, we evaluated 70698 obstetric patients who were admitted to the Third Affiliated Hospital of Guangzhou Medical University between January 1, 2009 and June 30, 2018. Subjects were divided into sepsis group and non-sepsis group based on the incidence of sepsis. Data about medical history (surgical and obstetric history) and demographic information were collected. The Mann-Whitney test was used to compare patient age, gestational age and duration of hospitalization between the two groups. Univariate and multivariate logistic regression models were used to analyze the etiology and the risk factors for maternal sepsis. Unadjusted and adjusted odds ratios (OR) are reported.

Results: A total of 561 of 70698 obstetric patients were diagnosed with infection; of the infected patients, 492 had non-sepsis associated infection (87.7%), while 69 had sepsis (12.3%). The morbidity rate of maternal sepsis was 9.76/10000; the fatality rate in the sepsis group was 11.6% (8/69). Emergency admission (OR = 2.183) or transfer (OR = 2.870), irregular prenatal care (OR = 2.953), labor induction (OR = 4.665), cervical cerclage (OR = 14.214), first trimester (OR = 6.806) and second trimester (OR = 2.09) were significant risk factors for maternal sepsis.

Conclusion: Mode of admission, poor prenatal care, labor induction, cervical cerclage, first trimester and second trimester pregnancy were risk factors for maternal sepsis. was the most common causative organism for maternal sepsis, and the uterus was the most common site of infection.
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http://dx.doi.org/10.12998/wjcc.v9.i26.7704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462250PMC
September 2021

Generation of an induced pluripotent stem cell line (FDCHi006-A) from a 7-year-old girl with central precocious puberty.

Stem Cell Res 2021 Sep 28;56:102542. Epub 2021 Sep 28.

Department of Traditional Chinese Medicine, Children's Hospital of Fudan University, Shanghai ty 201102, China. Electronic address:

Central precocious puberty (CPP) refers to a pediatric endocrine disease in which boys have secondary sexual characteristics before the age of 9 and girls before the age of 8. In this study, we generated an induced pluripotent stem cell line FDCHi006-A from the Peripheral blood cell of a typical central precocious patient who was only 7 years old. This iPSC line showed full pluripotency, normal karyotype and differentiation capacity without integrating vectors. It provides a useful model to study the underlying molecular mechanisms of CPP.
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http://dx.doi.org/10.1016/j.scr.2021.102542DOI Listing
September 2021

Accelerated antibacterial red-carbon dots with photodynamic therapy against multidrug-resistant .

Sci China Mater 2021 Sep 23:1-10. Epub 2021 Sep 23.

State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, 116024 China.

The emergence of antibiotic resistance in bacteria is a major public-health issue. Synthesis of efficient antibiotic-free material is very important for fighting bacterial infection-related diseases. Herein, red-carbon dots (R-CDs) with a broad range of spectral absorption (350-700 nm) from organic bactericides or intermediates were synthesized through a solvothermal route. The prepared R-CDs not only had intrinsic antibacterial activities, but also could kill multidrug-resistant bacteria (multidrug-resistant (MRAB) and multidrug-resistant (MRSA)) effectively by generating reactive oxygen species. Furthermore, R-CDs could eliminate and inhibit the formation of MRAB biofilms, while conferring few side effects on normal cells. A unique property of R-CDs was demonstrated upon treatment of antibiotic-sensitive MRAB-induced infected wounds. These data suggested that this novel R-CDs-based strategy might enable the design of next-generation agents to fight drug-resistant bacteria.

Electronic Supplementary Material: Supplementary material is available for this article at 10.1007/s40843-021-1770-0 and is accessible for authorized users.
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http://dx.doi.org/10.1007/s40843-021-1770-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8477720PMC
September 2021

Understanding the anchoring and catalytic effect of the [email protected] monolayer in lithium-selenium batteries: a first-principles study.

Nanoscale 2021 Oct 8;13(38):16316-16323. Epub 2021 Oct 8.

College of Materials Science and Engineering, Liaoning Technical University, Fuxin, Liaoning 123000, China.

The practical applications of lithium-selenium (Li-Se) batteries are impeded due to the low utilization of active selenium, sluggish kinetics, and volume change. The development of highly efficient host materials to suppress high-order polyselenide shuttling and accelerate LiSe conversion is essential for Li-Se batteries. Herein, a theoretical design of a [email protected] monolayer as a host material for ultra-high areal capacity Li-Se batteries is proposed by first-principles calculations. The investigations of the lowest energy configurations, binding energies, and the charge transfer indicate that the [email protected] monolayer could alleviate the reciprocating motion of high-order polyselenides and improve the cycling performance. Further electronic property calculations show that the semi-metallic characteristics of the [email protected] monolayer material are retained even after chemical adsorption with Se or LiSe molecules, which is beneficial for the utilization of active selenium. In addition, the crucial catalytic role of the [email protected] monolayer is investigated and the results indicate that the [email protected] monolayer could facilitate the formation and decomposition of LiSe molecules during the discharge and charge processes. Our present work would not only provide a deep understanding on the anchoring and catalytic effect of the [email protected] monolayer, but also demonstrate a general principle for the rational design and screening of advanced materials for high energy density Li-Se batteries.
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http://dx.doi.org/10.1039/d1nr03406eDOI Listing
October 2021

"Internal and External Combined" Nonradiative Decay-Based Nanoagents for Photoacoustic Image-Guided Highly Efficient Photothermal Therapy.

ACS Appl Mater Interfaces 2021 Oct 24;13(39):46353-46360. Epub 2021 Sep 24.

State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China.

Rational manipulation of nonradiative decay channels is of crucial significance to improve photothermal conversion efficiency (PCE) and design photothermal agents. We first used the "internal and external combined" nonradiative decay strategy to enhance PCE. Specifically, organic IR-Y6 NPs with strong NIR absorption and high molar extinction coefficient were prepared and characterized. By means of TD-DFT calculations and fs-TA spectroscopy, the dual nonradiative decay channels composed of the free rotor (external strategy) and ultrafast dark excited states (DESs) between S and S states (internal strategy) were proved, which significantly enhanced PCE, up to 66%. IR-Y6 NPs were applied to a mice tumor model for photoacoustic image-guided photothermal therapy, showing complete tumor ablation ability and good biocompatibility for the normal organs. This work is of significance to deeply understand the nonradiation decay mechanism and rational design of high-performance PTT agents.
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http://dx.doi.org/10.1021/acsami.1c14020DOI Listing
October 2021

Study on the Mechanism of Qigu Capsule in Upregulating NF-B/HIF-1 Pathway to Improve the Quality of Bone Callus in Mice at Different Stages of Osteoporotic Fracture Healing.

Evid Based Complement Alternat Med 2021 13;2021:9943692. Epub 2021 Sep 13.

Shi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

Objective: The present study intends to investigate the effects and underlying molecular mechanism of Qigu Capsule (QG) on fracture healing in mice with osteoporosis.

Methods: Ten-week-old female C57BL/6 mice were ovariectomized and three weeks later were evaluated for successful modeling. Then, all mice were prepared into models of transverse fracture in the right middle femoral shaft. Mice were treated daily using a gavage with normal saline (the NS group), Qigu Capsule (the QG group), or alendronate (the ALN group) postoperatively. Fracture callus tissues were collected and analyzed by X-ray, micro-CT, western blot (WB), and transmission electron microscope (TEM) on postoperation Day 14 (POD14), POD28, and POD42.

Results: (1) X-ray results showed that on POD14, the QG group had the fracture healing score significantly higher than the NS and ALN groups, and on POD28, it had the fracture healing score higher than the NS group, suggesting that QG could promote fracture healing. (2) Micro-CT results showed that on POD14, the QG group had tissue bone density (TMD) significantly higher than the NS and ALN groups, and on POD28 and POD42, it had bone volume fraction, trabecular number, and TMD significantly higher than the NS group. (3) WB results showed that, compared with the NS group, the QG group had significantly increased expression of nuclear factor kappa-B (NF-B), hypoxia-inducible factor-1 (HIF-1), bone alkaline phosphatase (BALP), runt-related transcription factor 2 (Runx2), bone Gla protein (BGP) and collagen I1 (COLI1) on POD14, significantly increased expression of NF-B, HIF-1, BALP and COLI1 on POD28, and significantly increased expression of NF-B, HIF-1, and Runx2 on POD42. (4) TEM scanning results showed that, compared with the NS and ALN groups, the QG group had significantly increased numbers of autophagic vacuoles (AVs) in osteocytes on POD14, POD28, and POD42.

Conclusion: QG could accelerate osteoporotic fracture healing by promoting bone formation and osteocyte autophagy, possibly through upregulating the NF-B/HIF-1 signaling pathway.
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http://dx.doi.org/10.1155/2021/9943692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455191PMC
September 2021

First-principles calculations on the deposition behavior of LiNa ( + ≤ 5) clusters during the hybrid storage of Li and Na atoms on graphene.

Phys Chem Chem Phys 2021 Oct 6;23(38):21817-21824. Epub 2021 Oct 6.

College of Materials Science and Engineering, Liaoning Technical University, Fuxin, Liaoning 123000, China.

A new strategy of sodium ion batteries with the hybrid storage of Li and Na ions has attracted much attention in the field of large-scale energy storage. For revealing the mechanism of hybrid storage of Li and Na atoms in carbon materials, the lowest energy configuration, adsorption energy, differential charge density and density of states of LiNa clusters on graphene, as a structural unit of carbon materials, were calculated and investigated based on first principles density functional theory. The calculation results show that the deposition behavior of single Li or Na atoms on graphene is similar, and both are preferentially deposited at the hollow of graphene (H-site). The Li atom is deposited preferentially over the Na atom, and the deposition height of the Li atom is lower. When the total number of metal atoms + ≥ 3, LiNa clusters are deposited on graphene in the form of a stereotypical atomic cluster, in which the Li atom is usually at the bottom of the LiNa cluster, while the Na atom is usually at the top of the cluster. The electronic structure analysis shows that the electrons of the LiNa cluster are transferred to the anti-bonding π orbitals adjacent to graphene. The 2s orbitals of Li atoms and the 2s and 2p orbitals of Na atoms are hybridized with the 2p orbitals of C atoms. Therefore, the Li-C bonds or Na-C bonds formed between Li or Na atoms and C atoms of graphene are usually ionic bonds with partial covalent bond properties. Meanwhile, the Li-Li, Na-Na or Li-Na bonds formed inside LiNa clusters are usually multiple metal-metal bonds.
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http://dx.doi.org/10.1039/d1cp01237aDOI Listing
October 2021

Lacticaseibacillus rhamnosus TR08 alleviated intestinal injury and modulated microbiota dysbiosis in septic mice.

BMC Microbiol 2021 09 18;21(1):249. Epub 2021 Sep 18.

Department of Critical Care Medicine, Jinling Hospital of Nanjing Medical University, 305 East Zhongshan Road, Nanjing, 225001, China.

Background: Probiotics are widely used in intestinal microbiota imbalance caused by sepsis, however, the protective mechanism is still unclear. This study aimed to explore protective effect of Lacticaseibacillus rhamnosus TR08 on intestinal injury in septic mice.

Results: The levels of serum inflammatory factors were reduced significantly in septic mice treated with L. rhamnosus TR08. The levels of sIgA in terminal ileum were significantly higher in probiotic treatment group than sepsis group. Intestinal pathological damage in septic mice improved and the expression of tight junction proteins increased after probiotic treatment. Sequencing of fecal microbiota showed that the abundance and diversity of probiotic treatment group were significantly better than those of sepsis group, and beneficial bacteria increased while some bacteria decreased in the phylum level.

Conclusion: L. rhamnosus TR08 could improve the integrity of intestinal barrier, enhance the intestinal mucosal immunity in septic mice, and rebalance the intestinal microecosystem.
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http://dx.doi.org/10.1186/s12866-021-02317-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449483PMC
September 2021

Reversing Multidrug Resistance by Inducing Mitochondrial Dysfunction for Enhanced Chemo-Photodynamic Therapy in Tumor.

ACS Appl Mater Interfaces 2021 Sep 17;13(38):45259-45268. Epub 2021 Sep 17.

State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, Hi-tech Zone, Dalian 116024, P.R. China.

Efficiency of standard chemotherapy is dramatically hindered by intrinsic multidrug resistance (MDR). Recently, to amplify therapeutic efficacy, photodynamic therapy (PDT)-induced mitochondrial dysfunction by decorating targeting moieties on nanocarriers has obtained considerable attention. Nevertheless, low targeting efficiency, complex synthesis routes, and difficulty in releasing contents become the major obstacles in further clinical application. Herein, an ingenious liposomal-based nanomedicine ([email protected]) was fabricated by encapsulating a mitochondria-anchored photosensitizer (Cy-Br) and paclitaxel (PTX) for realizing enhanced cooperation therapy. At the cellular level, [email protected] could hurdle endosomal traps to localize and implement PDT in mitochondria. Intriguingly, the PDT-induced mitochondrial dysfunction led to intracellular ATP reduction, which triggered the downregulated P-glycoprotein transportation capacity and thus resulted in diminishing the efflux of chemotherapeutic agents and increasing drug uptake by drug-resistant cells. The prepared nanomedicine eminently accumulated in the tumor site and acquired enhanced therapeutic efficiency on PTX-resistant lung cancer cells, which possessed great potential in circumventing MDR tumors.
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http://dx.doi.org/10.1021/acsami.1c12725DOI Listing
September 2021

Delayed neurological improvement is predictive to long-term clinical outcome on endovascular thrombectomy patients.

Interv Neuroradiol 2021 Sep 13:15910199211038207. Epub 2021 Sep 13.

Department of Neurology, 12579Medical School of Southeast University, Jinling Hospital, China.

Objectives: This study aims at exploring the 3-month outcome predicting ability of delayed neurological improvement and the cause of delayed neurological improvement.

Materials And Methods: Early neurological improvement and delayed neurological improvement were calculated to represent the neurological improvements. Good functional outcome was defined as a 90-day modified Rankin Scale score 0-2. We used multivariant logistic regression to explore the influential factors of good functional outcome as well as delayed neurological improvement. We applied net reclassification improvement and integrated discrimination improvement to assess the quantitative improvement of the predictive model.

Results: Early neurological improvement was observed in 50 (23%) patients and delayed neurological improvement exhibited in 67 (30%) patients. Early neurological improvement and delayed neurological improvement were both independent predictive factors to good functional outcome. In the basic model (adjusted for age, admission glucose level, baseline National Institute of Health Stroke Scale, and complications and number of retrieval attempts), early neurological improvement and delayed neurological improvement statistically improved the predictive ability (early neurological improvement: net reclassification improvement = 0.34, 95% confidence interval, 95% confidential interval (0.06, 0.69); integrated discrimination improvement = 0.05,  < 0.001; delayed neurological improvement: net reclassification improvement = 0.79, 95% confidential interval (0.47, 1.12); integrated discrimination improvement = 0.14,  < 0.001) delayed neurological improvement could predict clinical outcomes more accurately than early neurological improvement (early neurological improvement vs. delayed neurological improvement: integrated discrimination improvement = 0.09,  < 0.001). Moreover, delayed neurological improvement was affected by hypertension (odds ratio  = 0.40, 95% CI (0.18, 0.88),  = 0.02), early neurological improvement (odds ratio  = 20.10, 95% confidential interval (8.24, 19.02),  < 0.001), number of retrieval attempts (odds ratio  = 0.39, 95% confidential interval (0.24, 0.66),  < 0.001), and complication (odds ratio  = 0.25, 95% confidential interval (0.12, 0.54),  < 0.001).

Conclusions: Delayed neurological improvement could predict clinical outcomes more accurately than early neurological improvement. Hypertension, early neurological improvement, numbers of retrieval attempts, and complications were all predicting factors to delayed neurological improvement.
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http://dx.doi.org/10.1177/15910199211038207DOI Listing
September 2021

An Organic Nanotherapeutic Agent Self-Assembled from Cyanine and Cu (II) for Combined Photothermal and Chemodynamic Therapy.

Adv Healthc Mater 2021 Sep 13:e2101008. Epub 2021 Sep 13.

State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, 116024, China.

Although the combination of photothermal/chemodynamic therapy (PTT/CDT) based on various inorganic nanomaterials has promising anticancer effects, poor biocompatibility and biodegradability of inorganic nanoplatforms pose obstacles to their use in clinic. On the contrary, nanoscale metal-organic particles are considered to be a promising platform because of their biocompatibility and efficient metabolism. Herein, [email protected] NPs are prepared using the coordination-driven assembly of cyanine dyes with Cu ions. [email protected] NPs demonstrate excellent synergistic PTT/CDT, a high photothermal conversion efficiency (43%), and enhanced photostability. Moreover, Cu in the NPs can be reduced to Cu by glutathione (GSH) and can transform H O to •OH, which down-regulates intracellular GSH levels and up-regulates significant oxidative damage. Therefore, promising in vivo tumor ablation is observed at a low dose of [email protected], suggesting that the combination of PTT/CDT greatly improved the antitumor performance. [email protected] can further improve organic nano-systems for anti-tumor therapy by integrating PTT and CDT.
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http://dx.doi.org/10.1002/adhm.202101008DOI Listing
September 2021

TAK1 mediates neuronal pyroptosis in early brain injury after subarachnoid hemorrhage.

J Neuroinflammation 2021 Aug 30;18(1):188. Epub 2021 Aug 30.

Stroke Center & Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230036, Anhui, China.

Background: Innate immunity can facilitate early brain injury (EBI) following subarachnoid hemorrhage (SAH). Numerous studies suggest that pyroptosis could exacerbate extracellular immune responses by promoting secretion of inflammatory cytokines. Transforming growth factor-β-activated kinase 1 (TAK1) is a quintessential kinase that positively regulates inflammation through NF-κB and MAPK signaling cascades. However, the effects of TAK1 on neuroinflammation in EBI following SAH are largely unknown.

Methods: Two hundred and forty-six male C57BL/6J mice were subjected to the endovascular perforation model of SAH. A selective TAK1 inhibitor, 5Z-7-oxozeaenol (OZ) was administered by intracerebroventricular (i.c.v) injection at 30 min after SAH induction. To genetic knockdown of TAK1, small interfering RNA (siRNA) was i.c.v injected at 48 h before SAH induction. SAH grade, brain water content, BBB permeability, neurological score, western blot, real-time PCR, ELISA, transmission electron microscope, and immunofluorescence staining were performed. Long-term behavioral sequelae were evaluated by the rotarod and Morris water maze tests. Furthermore, OZ was added to the culture medium with oxyhemoglobin (OxyHb) to mimic SAH in vitro. The reactive oxygen species level was detected by DCFH-DA staining. Lysosomal integrity was assessed by Lyso-Tracker Red staining and Acridine Orange staining.

Results: The neuronal phosphorylated TAK1 expression was upregulated following SAH. Pharmacologic inhibition of TAK1 with OZ could alleviate neurological deficits, brain edema, and brain-blood barrier (BBB) disruption at 24 h after SAH. In addition, OZ administration restored long-term neurobehavioral function. Furthermore, blockade of TAK1 dampened neuronal pyroptosis by downregulating the N-terminal fragment of GSDMD (GSDMD-N) expression and IL-1β/IL-18 production. Mechanistically, both in vivo and in vitro, we demonstrated that TAK1 can induce neuronal pyroptosis through promoting nuclear translocation of NF-κB p65 and activating nucleotide-binding oligomerization domain (NOD)-like receptor pyrin domain containing 3 (NLRP3) inflammasome. TAK1 siRNA treatment mitigated SAH-induced neurobehavioral deficits and restrained phosphorylated NF-κB p65 expression and NLRP3 inflammasome activation. TAK1 blockade also ameliorated reactive oxygen species (ROS) production and prevented lysosomal cathepsin B releasing into the cytoplasm.

Conclusions: Our findings demonstrate that TAK1 modulates NLRP3-mediated neuronal pyroptosis in EBI following SAH. Inhibition of TAK1 may serve as a potential candidate to relieve neuroinflammatory responses triggered by SAH.
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http://dx.doi.org/10.1186/s12974-021-02226-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406585PMC
August 2021

Ectomycorrhizal fungi enhance the tolerance of phytotoxicity and cadmium accumulation in oak (Quercus acutissima Carruth.) seedlings: modulation of growth properties and the antioxidant defense responses.

Environ Sci Pollut Res Int 2021 Aug 28. Epub 2021 Aug 28.

College of Art and Sciences, The Ohio State University, Columbus, OH, 43210, USA.

Ectomycorrhizal fungi (EMF), which form symbiotic ectomycorrhiza with tree roots, mediate heavy metal tolerance of host plants. To investigate the roles of EMF in the growth, modulation of oxidative stress, and cadmium (Cd) accumulation and translocation in Quercus acutissima seedlings, ectomycorrhizal seedlings inoculated with Suillus luteus were treated with different Cd concentrations (0.1, and 5 mg kg) for 14 days. EMF accelerated seedling growth and Cd accumulation in roots under the highest Cd concentration of 5 mg kg. Catalase (CAT), ascorbate peroxidase (APX), and glutathione reductase (GR) activities increased in the leaves of ectomycorrhizal seedlings under the highest Cd concentration. Superoxide dismutase (SOD) trended to increase under both Cd concentrations. Although reduced glutathione (GSH) increased after inoculation of EMF under both Cd concentrations, the release of malondialdehyde increased in the leaves and roots under the highest Cd concentration, indicating that the defense role of EMF in Q. acutissima depends on the Cd concentration. These results indicate that EMF mitigate Cd stress by promoting plant growth and nutrient uptake while modulating the antioxidant system to reduce oxidative stress.
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http://dx.doi.org/10.1007/s11356-021-16169-3DOI Listing
August 2021

Obesity and Poststroke Fatigue: A 2-Year Longitudinal Study.

Neurol Ther 2021 Aug 26. Epub 2021 Aug 26.

Stroke Center and Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.

Introduction: Obesity is associated with fatigue in many diseases, but the correlation between obesity and poststroke fatigue (PSF) is unclear. The study aimed to investigate the relationship between body mass index (BMI) and the occurrence of and recovery from PSF.

Methods: Within 3 days of the onset of ischemic stroke, patients were consecutively recruited. We assessed PSF at admission and at 6, 12, and 24 months with the Fatigue Severity Scale (FSS). Multivariable logistic regression and restricted cubic spline function were used to explore the relationships between baseline BMI and the risk of PSF at different time points. The correlation between baseline BMI and the dynamic changes in the natural logarithm transformation of the FSS (lnFSS) score during the follow-up period was analyzed by the piecewise linear mixed-effects model.

Results: A total of 1026 stroke patients were included. Multivariable analyses indicated that obesity was associated with a decreased risk of early PSF (fatigue diagnosed at baseline) [odds ratio (OR) 0.61, 95% confidence interval (CI) 0.41-0.93] but an increased risk of late PSF (fatigue diagnosed 6 months after the index stroke) (OR 1.63, 95% CI 1.06-2.50 for 6 months; OR 1.87, 95% CI 1.18-2.96 for 12 months; OR 2.11, 95% CI 1.28-3.49 for 24 months). Longitudinal analyses indicated that in the late stage of fatigue, the higher the BMI category, the slower the rate of decrease was for the FSS score.

Conclusion: Obese patients are less likely to develop fatigue in the acute stage of ischemic stroke. However, they are more prone to late fatigue and exhibit a slower decline in the FSS score in the long term.
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http://dx.doi.org/10.1007/s40120-021-00276-xDOI Listing
August 2021

Green and cost-effective synthesis of flexible, highly conductive cellulose nanofiber/reduced graphene oxide composite film with deep eutectic solvent.

Carbohydr Polym 2021 Nov 31;272:118514. Epub 2021 Jul 31.

Beijing Key Laboratory of Lignocellulosic Chemistry, Beijing Forestry University, Beijing 100083, China. Electronic address:

Developing efficient strategy for nanomaterials dispersion is the key for promoting the utilization of cellulose-based composite in energy storage devices. In this study, an instant synthesis method for cellulose nanofiber (CNF)/reduced graphene oxide (rGO) composite film with a deep eutectic solvent (DES) based on choline chloride and urea as a media is developed. This DES shows favorable abilities of recyclability, materials dispersion, and could adjust the pH value for reaction systems of neutral to alkaline which in favor of electrostatic repulsion arising from deprotonated carboxyl groups at the composite surface. As-obtained films feature excellent flexibility, high electrical conductivity (as high as 26.47 S∙cm) and well electrochemical properties. Furthermore, a little amount of nitrogen atoms (~3.0 at%) could be introduced in the composite at a mild condition. Overall, this approach offers the potential for cost-effective, environmentally friendly and large-scale production of cellulose-based electrode and numerous advanced applications.
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http://dx.doi.org/10.1016/j.carbpol.2021.118514DOI Listing
November 2021

Effectiveness of a mindfulness intervention for older adults to improve emotional well-being and cognitive function in a Chinese population: A randomized waitlist-controlled trial.

Int J Geriatr Psychiatry 2021 Aug 20. Epub 2021 Aug 20.

Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China.

Background: To investigate the effect of a modified mindfulness-based stress reduction (mMBSR) program on mental well-being and cognitive function of older adults.

Method: Two hundred and fourty-six participants were randomly assigned to mMBSR (n = 120) group or waitlist control group which received mMBSR at 2-month (n = 123). Data collected at baseline, 2 and 4 months after recruitment.

Primary Outcome: mental well-being: Short Warwick-Edinburgh Mental Well-being Scale (SWEMWBS).

Secondary Outcomes: Five Facet Mindfulness Questionnaire Short Form, Montreal Cognitive Assessment (MOCA), Verbal Fluency Test (VFT), international shopping list test, self-compassion scale, peace of mind scale, geriatric depression scale (GDS), and Pittsburgh sleep quality index (PSQI). In modified-intention-to-treat analysis, paired t-test for within group comparison, and ANCOVA to compare group differences at 2-months with adjustment of baseline values.

Results: Most participants were female (83.7%), living with others (67.0%), and married (50.7%). No significant difference of baseline characteristics except sleep quality. At 2 months, intervention group reported better mental well-being (0.9, 95%CI: 0.1-1.8, p = 0.025) and less depressive symptoms (-1.0; 95%CI: -1.7 to -0.3, p = 0.004). Within group at 2 months, intervention group had improvement in: mental well-being (SWEMWBS: 22.5-23.4, p = 0.011), cognitive function (MOCA: 24.6-25.8, p < 0.001; VFT: 38.7-42.1, p < 0.001), depressive symptoms (GDS: 4.1-3.1, p < 0.001), and sleep quality (PSQI: 8.3-6.7, p < 0.001). All these changes, except mental well-being, were sustained at 4 months.

Discussion: Attrition rate was 14% and mindfulness intervention was found to be feasible and acceptable in older adults. Major limitation of the study was the absence of an active control group to control for non-specific effect.
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http://dx.doi.org/10.1002/gps.5616DOI Listing
August 2021

Atrial Fibrillation Detected by Single Time-Point Handheld Electrocardiogram Screening and the Risk of Ischemic Stroke.

Thromb Haemost 2021 Aug 16. Epub 2021 Aug 16.

Department of Medicine and Therapeutics, Division of Cardiology, Prince of Wales Hospital & Heart & Vascular Institute, The Chinese University of Hong Kong, Hong Kong.

Objective:  We evaluated stroke risk in patients with single time-point screen-detected atrial fibrillation (AF) and the effect of oral anticoagulants (OACs).

Methods:  Consecutive patients aged ≥65 years attending medical outpatient clinics were prospectively enrolled for AF screening using handheld single-lead electrocardiogram (ECG; AliveCor) from December 2014 to December 2017 (NCT02409654). Repeated screening was performed in patients with >1 visit during this period. Three cohorts were formed: screen-detected AF, clinically diagnosed AF, and no AF. Ischemic stroke risk was estimated using adjusted subdistribution hazard ratios (aSHRs) from multivariate regression and no AF as reference, and stratified according to OAC use.

Results:  Of 11,972 subjects enrolled, 2,238 (18.7%) had clinically diagnosed AF at study enrollment. The yield of screen-detected AF on initial screening was 2.3% ( = 223/9,734). AF was clinically diagnosed during follow-up in 2.3% ( = 216/9,440) and during subsequent screening in 71 initially screen-negative patients. Compared with no AF, patients with screen-detected AF without OAC treatment had the highest stroke risk (aSHR: 2.63; 95% confidence interval: 1.46-4.72), while aSHR for clinically diagnosed AF without OAC use was 2.01 (1.54-2.62). Among screen-detected AF, the risk of stroke was significantly less with OAC (no strokes in 196 person-years) compared with those not given OAC (12 strokes in 429 person-years),  = 0.01.

Conclusion:  The prognosis of single time-point ECG screen-detected AF is not benign. The risk of stroke is high enough to warrant OAC use, and reduced by OAC.
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http://dx.doi.org/10.1055/a-1588-8867DOI Listing
August 2021

A Versatile and Robust Platform for the Scalable Manufacture of Biomimetic Nanovaccines.

Adv Sci (Weinh) 2021 08 1;8(15):2002020. Epub 2021 May 1.

Department of Biomedical Engineering Columbia University New York NY 10027 USA.

Biomimetic strategies are useful for designing potent vaccines. Decorating a nanoparticulate adjuvant with cell membrane fragments as the antigen-presenting source exemplifies, such as a promising strategy. For translation, a standardizable, consistent, and scalable approach for coating nanoadjuvant with the cell membrane is important. Here a turbulent mixing and self-assembly method called flash nanocomplexation (FNC) for producing cell membrane-coated nanovaccines in a scalable manner is demonstrated. The broad applicability of this FNC technique compared with bulk-sonication by using ten different core materials and multiple cell membrane types is shown. FNC-produced biomimetic nanoparticles have promising colloidal stability and narrow particle polydispersity, indicating an equal or more homogeneous coating compared to the bulk-sonication method. The potency of a nanovaccine comprised of B16-F10 cancer cell membrane decorating mesoporous silica nanoparticles loaded with the adjuvant CpG is then demonstrated. The FNC-fabricated nanovaccines when combined with anti-CTLA-4 show potency in lymph node targeting, DC antigen presentation, and T cell immune activation, leading to prophylactic and therapeutic efficacy in a melanoma mouse model. This study advances the design of a biomimetic nanovaccine enabled by a robust and versatile nanomanufacturing technique.
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http://dx.doi.org/10.1002/advs.202002020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8336609PMC
August 2021

Photocleavable core cross-linked polymeric micelles of polypept(o)ides and ruthenium(II) complexes.

J Mater Chem B 2021 Oct 13;9(39):8211-8223. Epub 2021 Oct 13.

Leiden Academic Centre for Drug Research (LACDR), Leiden University, Einsteinweg 55, 2333CC Leiden, The Netherlands.

Core cross-linking of polymeric micelles has been demonstrated to contribute to enhanced stability that can improve the therapeutic efficacy. Photochemistry has the potential to provide spatial resolution and on-demand drug release. In this study, light-sensitive polypyridyl-ruthenium(II) complexes were combined with polypept(o)ides for photocleavable core cross-linked polymeric micelles. Block copolymers of polysarcosine--poly(glutamic acid) were synthesized by ring-opening -carboxyanhydride polymerization and modified with aromatic nitrile-groups on the glutamic acid side chain. The modified copolymers self-assembled into micelles and were cross-linked by -diaquabis(2,2'-bipyridine)-ruthenium(II) ([Ru(bpy)(HO)]) or -diaquabis(2,2'-biquinoline)-ruthenium(II) ([Ru(biq)(HO)]). Depending on the flexibility and hydrophobicity of the nitrile linker, either small spherical structures ( 45 nm, PDI 0.11) or worm-like micelles were obtained. The cross-linking reaction did not affect the overall size distribution but induced a change in the metal-to-ligand charge transfer peak from 482 to 420 nm and 592 to 548 nm. The cross-linked micelles displayed colloidal stability after incubation with human blood plasma and during gel permeation chromatography in hexafluoroisopropanol. Light-induced cleavage of [Ru(bpy)(HO)] was accomplished within 300 s, while [Ru(biq)(HO)] could not be completely released. Analysis in HuH-7 cells revealed increased cytotoxicity micellar delivery of [Ru(bpy)(HO)] but mostly irradiation damage for [Ru(biq)(HO)]. Further evaluation confirmed stable circulation pointing towards the future development of quick-release complexes.
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http://dx.doi.org/10.1039/d1tb01336jDOI Listing
October 2021

The Prognostic Determinant of Interleukin-10 in Patients with Acute Ischemic Stroke: An Analysis from the Perspective of Disease Management.

Dis Markers 2021 17;2021:6423244. Epub 2021 Jul 17.

Department of Neurology, Second Hospital of Jilin University, Changchun, China.

Background: In patients with ischemic stroke, the role of anti-inflammatory cytokine Interleukin-10 (IL-10) in predicting risk and outcomes is not very clear. This study is aimed at prospectively assessing the prognostic determinant value of IL-10 in patients with acute ischemic stroke in a cohort of Chinese people.

Methods: In a prospective cohort study, consecutive first-ever patients with acute ischemic stroke admitted to our hospital were included from October 2019 to October 2020. The serum level of IL-10 was measured at baseline. A structured follow-up telephone interview was performed on day 90 after admission. Logistic regression analyses were used to assess the prognostic value of IL-10 to predict the poor functional outcome (defined as a modified Rankin Scale score of 3 to 6) and mortality.

Results: The median age of the 236 enrolled patients was 65 years (interquartile range (IQR), 56-76), and 57.6% were male. There was a negative correlation between the National Institutes of Health Stroke Scale (NIHSS) score and IL-10 serum levels ( (Spearman) = -0.221, = 0.001). Patients with elevated IL-10 levels (> the highest quartile = 5.24 pg/mL; = 79) were at significantly lower risk of poor functional outcomes (odds ratio (OR), 0.35; 95% confidence interval (CI), 0.19 to 0.63; < 0.001) and mortality (OR = 0.24; 95% CI = 0.11-0.52; < 0.001) compared with patients with IL-10 levels in the lowest three quartiles.

Conclusions: Reduced serum levels of IL-10 were independently associated with both the clinical severity at admission and a poor functional prognosis in ischemic stroke patients, suggesting that the anti-inflammatory cytokine IL-10 was an important prognostic determinant.
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http://dx.doi.org/10.1155/2021/6423244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313368PMC
July 2021

An Approach to Developing Cyanines with Simultaneous Intersystem Crossing Enhancement and Excited-State Lifetime Elongation for Photodynamic Antitumor Metastasis.

J Am Chem Soc 2021 Aug 29;143(31):12345-12354. Epub 2021 Jul 29.

State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China.

Heavy-atom-based photosensitizers usually exhibit shortened triplet-state lifetimes, which is not ideal for hypoxic tumor photodynamic therapy. Although several heavy-atom-free photosensitizers possess long triplet-state lifetimes, the clinical applicability is limited by their short excitation wavelengths, poor photon capture abilities, and intrinsically hydrophobic structures. Herein we developed a novel NIR heavy-atom-free photosensitizer design strategy by introducing sterically bulky and electron-rich moieties at the position of the pentamethine cyanine (Cy5) skeleton, which simultaneously enhanced intersystem crossing (ISC) and prolonged excited-state lifetime. We found that the O generation ability is directly correlated to the electron-donating ability of the substituent in cyanine, and the excited-state lifetime was simultaneously much elongated when the substituents were anthracene derivatives substituted at the -position. Our star compound, ANOMe-Cy5, exhibits intense NIR absorption, the highest O quantum yield (4.48-fold higher than Cy5), the longest triplet-state lifetime (9.80-fold longer than Cy5), and lossless emission intensity (nearly no change compared with Cy5). Such excellent photophysical properties coupled with its inherently cationic and hydrophilic nature enable the photosensitizer to realize photoablation of solid tumor and antitumor lung metastasis. This study highlights the design of a new generation of NIR photosensitizers for imaging-guided photodynamic cancer treatment.
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http://dx.doi.org/10.1021/jacs.1c06275DOI Listing
August 2021

Expression and clinical significance of miR-338 and miR-20a in serum of patients with gastric carcinoma.

Am J Transl Res 2021 15;13(6):6620-6628. Epub 2021 Jun 15.

Department of Oncology, Wuhan Fourth Hospital, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430034, Hubei Province, China.

Objective: This research intended to explore the content and the role of miR-338 and miR-20a in the serum of patients with gastric carcinoma (GC).

Methods: Sixty-seven patients with GC, diagnosed and treated for the first time in our hospital from February 2014 to October 2016 were selected as the observation group (OG), and 45 healthy people were selected as the control group (CG). miR-338 and miR-20a of the CG and the OG were tested using qRT-PCR, and the correlation between the two indexes was analyzed by Pearson test. The diagnostic value of miR-338 and miR-20a in GC was analyzed by receiver operating characteristic curve (ROC). The correlation of miR-338 and miR-20a with clinical data was compared, and the correlation of the two with the survival of patients was observed. The independent prognostic factors in patients with GC were analyzed by Cox regression.

Results: miR-338 expression was low in GC patients' serum, while miR-20a was high in GC patients. The expression of the two indexes was negatively correlated (r=-0.609, P<0.001). The areas under the curve of miR-338 and miR-20a were 0.849 and 0.865 respectively. Low expression of miR-338 and high expression of miR-20a were correlated to large tumors, low differentiation degree, high possibility of lymph node metastasis, and late TNM stage of GC patients. Multivariate Cox results revealed that tumor size, lymph node metastasis, differentiation degree, TNM stage, miR-338 and miR-20a were independent prognostic factors.

Conclusion: miR-338 and miR-20a are expected to be serological indicators for GC diagnosis and prognosis.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8290677PMC
June 2021

The Impact of Policy and COVID-19 Prevention Strategies in China: A Qualitative Study.

Res Sq 2021 Jul 15. Epub 2021 Jul 15.

Background: Ongoing infection-control strategies have played an important role in preventing the spread of COVID-19 and mitigating its effects. However, limited studies have explored the influence of these strategies from the perspective of COVID-19 patients. This study aims to describe the impact of governmental COVID-19 policy and prevention strategies on COVID-19 patients in China.

Methods: Twenty-six people who had been treated for COVID-19 in a COVID-19-designated facility in Shanghai, China, were recruited using the purposive sampling method. These individuals participated in semi-structured interviews by phone from April to June 2020. A thematic content analysis approach was conducted. The consolidated criteria for reporting qualitative studies checklist was applied.

Results: Three categories of themes emerged from the thematic analysis. The first was "Consciously adhere to COVID-19-related infection-control strategies." Most of these patients followed the COVID-19 strategies throughout the stages of their illness. The second category was "Positive experiences of the COVID-19-related infection-control strategies." These patients shared their positive experiences of the governmental infection-control strategies to contain the virus; for example, they experienced a quick and adequate medical response, they were confident in the medical system, or they received help from community workers. The third category was "Negative experiences of the COVID-19-related infection-control strategies." These patients experienced psychological distress, stigma, privacy exposures, and inconveniences from the governmental strategies.

Conclusions: Our findings exemplify how patients with COVID-19 adhered to the infection-control strategies in China. It is urgent to develop a culturally sensitive intervention to eliminate the psychological distress and stigma of patients with COVID-19 and to protect their privacy during and after the pandemic.
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http://dx.doi.org/10.21203/rs.3.rs-710681/v1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8288153PMC
July 2021

Analog memristive synapse based on topotactic phase transition for high-performance neuromorphic computing and neural network pruning.

Sci Adv 2021 Jul 16;7(29). Epub 2021 Jul 16.

School of Integrated Circuits, Beijing National Research Center for Information Science and Technology (BNRist), Tsinghua University, Beijing 100084, China.

Inspired by the human brain, nonvolatile memories (NVMs)-based neuromorphic computing emerges as a promising paradigm to build power-efficient computing hardware for artificial intelligence. However, existing NVMs still suffer from physically imperfect device characteristics. In this work, a topotactic phase transition random-access memory (TPT-RAM) with a unique diffusive nonvolatile dual mode based on SrCoO is demonstrated. The reversible phase transition of SrCoO is well controlled by oxygen ion migrations along the highly ordered oxygen vacancy channels, enabling reproducible analog switching characteristics with reduced variability. Combining density functional theory and kinetic Monte Carlo simulations, the orientation-dependent switching mechanism of TPT-RAM is investigated synergistically. Furthermore, the dual-mode TPT-RAM is used to mimic the selective stabilization of developing synapses and implement neural network pruning, reducing ~84.2% of redundant synapses while improving the image classification accuracy to 99%. Our work points out a new direction to design bioplausible memristive synapses for neuromorphic computing.
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http://dx.doi.org/10.1126/sciadv.abh0648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284889PMC
July 2021

Predicting factors of central lymph node metastasis and BRAF mutation in Chinese population with papillary thyroid carcinoma.

World J Surg Oncol 2021 Jul 13;19(1):211. Epub 2021 Jul 13.

Department of Pathology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, 7# Weiwu Road, Zhengzhou, 450003, Henan Province, China.

Objective: The aim of this study was to evaluate the predictive factors of central lymph node metastasis (CLNM) and BRAF mutation in Chinese patients with papillary thyroid carcinoma (PTC).

Methods: A total of 943 PTC patients who underwent thyroidectomy from 2014 to 2016 at our hospital were enrolled. Those patients were divided into PTC > 10 mm and papillary thyroid microcarcinoma (PTMC) groups by tumor size. The BRAF mutation was examined by quantitative real-time PCR. Univariate and multivariate analyses were used to examine risk factors associated with CLNM and the BRAF mutation.

Results: The frequency of CLNM was 53% (505/943). Both univariate and multivariate analyses suggested that the risk factors for CLNM in PTC patients were male, younger age, and larger tumor size (P < 0.05). Coexistent Hashimoto thyroiditis (HT) was an independent protective factor against CLNM when the tumor was > 10 mm (P = 0.006). Stratified analysis revealed that male, age ≤ 30 years, and tumor size > 5 mm were independent risk factors for CLNM. The BRAF mutation rate was 85%. Multivariate logistic regression analysis revealed that age (P < 0.001) and coexistent HT (P = 0.005) were independent predictive factors of BRAF mutation in PTC patients. Only age was a risk factor for the BRAF mutation when the tumor was > 10 mm (P = 0.004). In the PTMC group, the BRAF mutation was significantly correlated with tumor size (P < 0.001) and coexistent HT (P = 0.03). Stratified analysis revealed that age > 30 years and tumor size > 5 mm were independent predictive factors of BRAF mutation. Furthermore, the incidence of CLNM was significantly higher in BRAF mutation-positive patients (P = 0.009) when the tumor was ≤ 5 mm.

Conclusion: The factors male, younger age (≤ 30 years), large tumor size (> 5 mm), and coexistent HT are independent predicative factors for CLNM. The BRAF mutation is associated with both large size and without HT in PTMC patients, age > 30 years in the PTC > 10 mm group. The BRAF mutation was an independent risk factor for CLNM when the tumor was ≤ 5 mm. For optimal management, these features should be comprehensively evaluated to determine the initial surgical approach for PTC patients.
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http://dx.doi.org/10.1186/s12957-021-02326-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8278623PMC
July 2021

Successfully Managing Cornual Heterotopic Pregnancy:A Case Report and Literature Review.

Chin Med Sci J 2021 Jun;36(2):161-170

Department of Gynecology Endocrinology, Chongqing Health Center for Women and Children, Chongqing 401147, China.

Cornual heterotopic pregnancy is an extremely rare, life-threatening complication during pregnancy. Here, we report a 33-year-old woman who suffered cornual heterotopic pregnancy after fertilization embryo transfer. To prevent rupture during heterotopic pregnancy, she received laparoscopic surgery to remove the ectopic gestational sac at 7weeks of gestation. Ultimately, she delivered a healthy boy at 38 weeks of gestation. Here, we also review the clinical presentations, risk factors, treatment options and outcomes of cornual heterotopic pregnancy.
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http://dx.doi.org/10.24920/003793DOI Listing
June 2021

Comparative Effectiveness of Interventions for Global Cognition in Patients With Mild Cognitive Impairment: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials.

Front Aging Neurosci 2021 18;13:653340. Epub 2021 Jun 18.

Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China.

There is a lack of study comprehensively comparing the effects of all existing types of interventions on global cognition among patients with mild cognitive impairment (MCI). To conduct a network meta-analysis to evaluate the effectiveness of different types of interventions in improving global cognition among MCI patients. Randomized controlled trials (RCTs) assessing the effects of pharmacological or non-pharmacological interventions on the Mini-Mental State Examination (MMSE) in MCI patients were included. Two authors independently screened the studies and extracted the data. Random-effects network meta-analysis was used to synthesize the data. Results were summarized as mean difference (MD) and corresponding 95% CIs of MMSE in forest plots. Fifty RCTs with 5,944 MCI patients met the inclusion criteria and 49 were included in the network meta-analysis. Compared with the control group, cognition-based intervention (MD = 0.80, 95% CI 0.04-1.57), physical exercise (MD = 1.92, 95% CI 1.19-2.64), combined physical exercise and cognition-based intervention (MD = 1.86, 95% CI 0.60-3.12), and antioxidants (MD = 0.94, 95% CI 0.04-1.83) had positive effects on MMSE in participants with MCI. There was no significant difference between all other interventions included and the control group. This study suggested that cognition-based intervention, physical exercise, combined physical exercise and cognition-based intervention, and antioxidants could be among the most effective interventions on global cognition in older adults with MCI. The availability, acceptability, and cost-effectiveness of interventions should also be taken into consideration when selecting interventions. PROSPERO CRD42020171985.
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http://dx.doi.org/10.3389/fnagi.2021.653340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249717PMC
June 2021

A Novel Photosensitizer for Lipid Droplet-Location Photodynamic Therapy.

Front Chem 2021 14;9:701771. Epub 2021 Jun 14.

State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, China.

Lipid droplets (LDs), an extremely important cellular organelle, are responsible for the storage of neutral lipids in multiple biological processes, which could be a potential target site for photodynamic therapy (PDT) of cancer. Herein, a lipid droplet-targeted photosensitizer (BODSeI) is developed, allowing for fluorescence imaging-guided PDT. Owing to the location of lipid droplets, BODSeI demonstrates enhanced PDT efficiency with an extremely low IC50 value (around 125 nM). Besides, BODSeI shows good biocompatibility and high photostability. Therefore, BODSeI is promising for droplet-location PDT, which may trigger wide interest for exploring the pathway of lipid droplet-location PDT.
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http://dx.doi.org/10.3389/fchem.2021.701771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236597PMC
June 2021
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