Publications by authors named "Weiyue Li"

5 Publications

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Diagnostic performance of elastography for breast non-mass lesions: A systematic review and meta-analysis.

Eur J Radiol 2021 Oct 2;144:109991. Epub 2021 Oct 2.

Department of Ultrasound, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, Guangdong, China. Electronic address:

Purpose: This systematic review and meta-analysis aimed to evaluate the diagnostic performance of ultrasound elastography in the differentiation of benign and malignant breast non-mass lesions (NMLs).

Methods: PubMed, Cochrane Library, and Embase databases were searched for eligible studies up to end of June 2021. The diagnostic performance of elastography for NMLs was investigated using pooled sensitivity and specificity, likelihood ratio, diagnostic odds ratio (DOR), post-test probability, and the area under hierarchical summary receiver operating characteristic curve (HSROC).

Results: Eleven studies involving 812 NMLs (malignant 414) were included. The pooled sensitivity, specificity, DOR, positive likelihood ratio, and negative likelihood of elastography for the differentiation of benign and malignant breast NMLs were 79% (95 %CI: 71-85), 86% (95 %CI: 79-91), 23.32 (95 %CI: 13.38-40.66), 5.67 (95 %CI: 3.79-8.47), and 0.24 (95 %CI: 0.17-0.34), respectively. No significant publication bias existed. The area under the HSROC curve was 90% (95 %CI: 87-92). Fagan plots demonstrated good clinical utility. However, substantial heterogeneity existed. Country, measurement index, and number of lesions served as potential sources of heterogeneity.

Conclusions: The results of this study suggest that elastography has high diagnostic accuracy in differentiating between malignant and benign NMLs. Elastography can be a feasible and non-invasive tool for breast NMLs.
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http://dx.doi.org/10.1016/j.ejrad.2021.109991DOI Listing
October 2021

Impact of COVID-19 on air quality in the Yangtze River Delta, China.

Environ Monit Assess 2021 Jul 27;193(8):523. Epub 2021 Jul 27.

School of Environmental and Geographical Sciences, Shanghai Normal University, Shanghai, 200234, China.

To investigate the effect of nationwide restrictions due to COVID-19 on air quality in the Yangtze River Delta (YRD), China, we defined four periods named period I (January 1 to 23, 2020), period II (January 24 to February 23), period III (February 24 to April 7), and period IV (April 8 to May 31), which indicated normal period, lockdown period, regional work resumption period, and nationwide work resumption period, respectively. Hourly PM, PM, NO, SO, CO, and O in 41 cities in the YRD region were analyzed. Compared to period I, NO decreased by 58% during period II and increased in periods III and IV. SO remained constant during the four periods (7-8 μg/m). Higher PM concentration was monitored during period II (41 μg/m) when compared to period III (35 μg/m), which was resulted from the enhanced secondary formation. Spatial distribution analysis further indicated that PM in the northern YRD during period II was higher than that during period III, whereas PM in the southern YRD in the period II was similar to that in period III. The results demonstrated that PM shows a nonlinear response to the reduction of its precursors, and this phenomenon varies in different areas. Compared to periods I (36 μg/m) and III (64 μg/m), relatively higher O during period II (64 μg/m) was probably resulted from less NO emission and hence weakened NO titration effect. The study suggested that coordinated and balanced measures are needed to improve air quality.
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http://dx.doi.org/10.1007/s10661-021-09342-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315727PMC
July 2021

Extreme rainfall trends of 21 typical urban areas in China during 1998-2015 based on remotely sensed data sets.

Environ Monit Assess 2019 Nov 1;191(12):709. Epub 2019 Nov 1.

Institute of Tibetan Plateau Research, Chinese Academy of Sciences, Beijing, 100101, China.

With the increase of population, many cities are growing in size at a phenomenal rate. Urbanization changes the urban underlying surface, influences the micro-climate, and sometimes affects the local precipitation process. In this study, we investigated the trends of extreme rainfall in China's 21 typical urban areas. Based on a series of daily rainfall and "Urban/built-up" dataset from TMPA 3B42 and MCD12Q1 products in China, trends in extreme precipitation, with the threshold defined as 95th (pre95p) and 99th (pre99p) percentiles of annual rain days during 1998-2015, have been assessed in China, and especially in 21 typical urban areas from 1998 to 2015. The tendency curves in extreme rainfall of different years are presented. In this period, more than 66% regions of China covered by TMPA 3B42 have increasing trends in extreme rainfall with pre95p threshold. The 21 typical urban areas showed different trends-in over half of these areas, upward tendencies in extreme rainfall were observed, particularly in Dalian, Beijing, and Chongqing. Seventeen urban areas showed increasing tendencies in pre95p extreme rainfall days, including Shanghai, Nanjing, Hangzhou, and Suzhou in the Yangtze River Delta region. The results also illustrate that southeastern coastal urban areas of China may have experienced decreasing occurrences in extreme rainfall.
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http://dx.doi.org/10.1007/s10661-019-7900-7DOI Listing
November 2019

Detecting GPC3-Expressing Hepatocellular Carcinoma with L5 Peptide-Guided Pretargeting Approach: In Vitro and In Vivo MR Imaging Experiments.

Contrast Media Mol Imaging 2018 10;2018:9169072. Epub 2018 Sep 10.

Department of Medical Imaging Centre, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Objective: To investigate the potential of L5 peptide-guided pretargeting approach to identify GPC3-expressing hepatocellular carcinoma (HCC) using ultrasmall superparamagnetic iron oxide (USPIO) as the MR probe.

Methods: Immunofluorescence with carboxyfluorescein- (FAM-) labeled L5 peptide was performed in HepG2 cells. Polyethylene glycol-modified USPIO (PEG-USPIO) and its conjugation with streptavidin (SA-PEG-USPIO) were synthesized, and their hydrodynamic diameters, zeta potential, T relaxivity, and cytotoxicity were measured. In vitro and in vivo two-step pretargeting MR imaging was performed on HepG2 cells and tumor-bearing mice after the administration of biotinylated L5 peptide (first step), followed by SA-PEG-USPIO (second step). Prussian blue staining was performed to assess iron deposition in tumors.

Results: The high specificity of L5 peptide for GPC3 was demonstrated. Generation of SA-PEG-USPIO nanoparticles with good biocompatibility (an average hydrodynamic diameter of 35.97 nm and a zeta potential of -7.91 mV), superparamagnetism (  = 0.1039 × 10 mMs), and low toxicity was achieved. The pretargeting group showed more enhancement than the nonpretargeting group both in vitro (60% vs 20%, < 0.05) and in vivo (32% vs 6%, < 0.001). Substantial iron deposition was only observed in HepG2 cells and tumors in the pretargeting group.

Conclusion: L5 peptide-guided, two-step pretargeting approach with USPIO as the MR imaging probe is a lucrative strategy to specifically identify GPC3-expressing HCC.
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http://dx.doi.org/10.1155/2018/9169072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151370PMC
January 2019

The experiences of balloon-expandable stent in symptomatic stenosis of middle cerebral artery.

Springerplus 2016 24;5(1):1413. Epub 2016 Aug 24.

The Cerebrovascular Disease Center, The Third Hospital of Xingtai, No. 108, Steel Road (North), Qiaoxi District, Xingtai City, 054000 Hebei Province China.

Background: Stent placement for middle cerebral artery (MCA) stenosis remains a technical and clinical challenge. Our purpose was to assess the safety and feasibility of balloon-expandable stent (BES) for patients with symptomatic M1 stenosis of MCA, and to introduce our experience during the procedure.

Methods: In the study, we analyzed retrospectively 37 patients with M1 stenosis of the MCA ranged from 70 to 90 % in diameter reduction and refractory to medical therapy between January 2012 and January 2015. All the patients underwent angioplasty and stenting with BES, and followed up continuously.

Results: Thirty-five out of 37 patients were successfully followed up and available until now. The technical successful rate was 100 % for all the lesions. The complication rate was 0 during the procedure. Stroke occurred to one patient at 4th day after the procedure. There were two patients experiencing slight stroke after 8 months. Two patients were found re-stenosis >50 % without any symptom. The stroke rate of 12 months was 8.57 % (3/35).

Conclusions: Angioplasty associated with BES appears to be safe and feasible for the patients with symptomatic M1 stenosis of MCA. Our experiences about the BES may be valuable for decreasing the complication. However, further study is needed.
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http://dx.doi.org/10.1186/s40064-016-3078-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996817PMC
September 2016
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