Weiya Xia

Weiya Xia

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Removal of N-Linked Glycosylation Enhances PD-L1 Detection and Predicts Anti-PD-1/PD-L1 Therapeutic Efficacy.

Cancer Cell 2019 Aug 18;36(2):168-178.e4. Epub 2019 Jul 18.

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Graduate Institute of Biomedical Sciences and Center for Molecular Medicine, China Medical University, Taichung 404, Taiwan; Department of Biotechnology, Asia University, Taichung 413, Taiwan; Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.06.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6793936PMC
August 2019

Blocking autophagy flux promotes interferon-alpha-mediated apoptosis in head and neck squamous cell carcinoma.

Cancer Lett 2019 Jun 9;451:34-47. Epub 2019 Mar 9.

Department of Oral Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China; Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai, 200011, China. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2019.02.052DOI Listing
June 2019

MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1.

Gastroenterology 2019 05 31;156(6):1849-1861.e13. Epub 2019 Jan 31.

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas; Graduate Institute of Biomedical Sciences and Center for Molecular Medicine, China Medical University, Taichung, Taiwan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00165085193034
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http://dx.doi.org/10.1053/j.gastro.2019.01.252DOI Listing
May 2019

Palmitoylation stabilizes PD-L1 to promote breast tumor growth.

Cell Res 2019 01 4;29(1):83-86. Epub 2018 Dec 4.

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.

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http://www.nature.com/articles/s41422-018-0124-5
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http://dx.doi.org/10.1038/s41422-018-0124-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318320PMC
January 2019

Generation of an induced pluripotent stem cell line from an individual with a heterozygous RECQL4 mutation.

Stem Cell Res 2018 12 2;33:36-40. Epub 2018 Oct 2.

Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX 77030, USA; Center for Stem Cell and Regenerative Medicine, The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA; Center for Precision Health, School of Biomedical Informatics and School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S18735061183024
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http://dx.doi.org/10.1016/j.scr.2018.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317900PMC
December 2018

Targeting PKCδ as a Therapeutic Strategy against Heterogeneous Mechanisms of EGFR Inhibitor Resistance in EGFR-Mutant Lung Cancer.

Cancer Cell 2018 12;34(6):954-969.e4

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Center for Molecular Medicine and Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404, Taiwan; Department of Biotechnology, Asia University, Taichung 413, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886126PMC
December 2018

Altered expression pattern of circular RNAs in metastatic oral mucosal melanoma.

Am J Cancer Res 2018 1;8(9):1788-1800. Epub 2018 Sep 1.

Department of Oral Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176177PMC
September 2018

Exosomal PD-L1 harbors active defense function to suppress T cell killing of breast cancer cells and promote tumor growth.

Cell Res 2018 08 29;28(8):862-864. Epub 2018 Jun 29.

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.

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http://www.nature.com/articles/s41422-018-0060-4
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http://dx.doi.org/10.1038/s41422-018-0060-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082826PMC
August 2018

Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1.

Mol Cell 2018 08;71(4):606-620.e7

Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Graduate School of Biomedical Sciences, University of Texas Health Science Center, Houston, TX 77030, USA; Graduate Institute of Biomedical Sciences and Center for Molecular Medicine, China Medical University, Taichung 404, Taiwan; Department of Biotechnology, Asia University, Taichung 413, Taiwan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765183059
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http://dx.doi.org/10.1016/j.molcel.2018.07.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6786495PMC
August 2018

Juxtacrine Signaling Inhibits Antitumor Immunity by Upregulating PD-L1 Expression.

Cancer Res 2018 07 22;78(14):3761-3768. Epub 2018 May 22.

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-18-0040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050079PMC
July 2018

Establishment of a human embryonic stem cell line with homozygous TP53 R248W mutant by TALEN mediated gene editing.

Stem Cell Res 2018 05 27;29:215-219. Epub 2018 Apr 27.

Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA; The University of Texas, MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX 77030, USA; Center for Stem Cell and Regenerative Medicine, The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA; Center for Precision Health, School of Biomedical Informatics and School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2018.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021017PMC
May 2018

Angiogenin/Ribonuclease 5 Is an EGFR Ligand and a Serum Biomarker for Erlotinib Sensitivity in Pancreatic Cancer.

Cancer Cell 2018 04 29;33(4):752-769.e8. Epub 2018 Mar 29.

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, Houston, TX 77030, USA; Graduate School of Biomedical Sciences, The University of Texas Health Science Center, Houston, TX 77030, USA; Graduate Institute of Biomedical Sciences and Center for Molecular Medicine, China Medical University, Taichung 404, Taiwan; Department of Biotechnology, Asia University, Taichung 413, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.02.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893359PMC
April 2018

A homozygous p53 R282W mutant human embryonic stem cell line generated using TALEN-mediated precise gene editing.

Stem Cell Res 2018 03 28;27:131-135. Epub 2018 Jan 28.

Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA; The University of Texas MD Anderson Cancer Center, UTHealth Graduate School of Biomedical Sciences, Houston, TX 77030, USA; Center for Stem Cell and Regenerative Medicine, The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA; Center for Precision Health, School of Biomedical Informatics and School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2018.01.035DOI Listing
March 2018

Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1.

Cancer Cell 2018 02;33(2):187-201.e10

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, Houston, TX 77030, USA; Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA; Graduate Institute of Biomedical Sciences and Center for Molecular Medicine, China Medical University, Taichung 404, Taiwan; Department of Biotechnology, Asia University, Taichung 413, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824730PMC
February 2018

The role of PRMT1 in EGFR methylation and signaling in MDA-MB-468 triple-negative breast cancer cells.

Breast Cancer 2018 Jan 22;25(1):74-80. Epub 2017 Jun 22.

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX, USA.

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http://dx.doi.org/10.1007/s12282-017-0790-zDOI Listing
January 2018

A UBE2O-AMPKα2 Axis that Promotes Tumor Initiation and Progression Offers Opportunities for Therapy.

Cancer Cell 2017 02 2;31(2):208-224. Epub 2017 Feb 2.

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Cancer Biology Program, The University of Texas Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463996PMC
February 2017

Deubiquitination and Stabilization of PD-L1 by CSN5.

Cancer Cell 2016 Dec 17;30(6):925-939. Epub 2016 Nov 17.

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, Houston, TX 77030, USA; Graduate School of Biomedical Sciences, The University of Texas Health Science Center, Houston, TX 77030, USA; Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University, Taichung 404, Taiwan; Department of Biotechnology, Asia University, Taichung 413, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.10.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5171205PMC
December 2016

AKT1 Inhibits Epithelial-to-Mesenchymal Transition in Breast Cancer through Phosphorylation-Dependent Twist1 Degradation.

Cancer Res 2016 Mar 12;76(6):1451-62. Epub 2016 Jan 12.

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University, Taichung, Taiwan. Department of Biotechnology, Asia University, Taichung, Taiwan. Graduate School of Biomedical Sciences, The University of Texas Health Science Center, Houston, Texas.

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http://cancerres.aacrjournals.org/content/early/2016/01/12/0
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http://cancerres.aacrjournals.org/content/early/2016/01/12/0
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http://cancerres.aacrjournals.org/content/early/2016/03/03/0
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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-15-1941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794388PMC
March 2016

EGFR Signaling Enhances Aerobic Glycolysis in Triple-Negative Breast Cancer Cells to Promote Tumor Growth and Immune Escape.

Cancer Res 2016 Mar 12;76(5):1284-96. Epub 2016 Jan 12.

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Houston, Texas. Graduate Institute of Cancer Biology and Center for Molecular Medicine, China Medical, University, Taichung, Taiwan. Department of Biotechnology, Asia University, Taichung, Taiwan.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-2478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775355PMC
March 2016

Phosphorylation of EZH2 at T416 by CDK2 contributes to the malignancy of triple negative breast cancers.

Am J Transl Res 2015 15;7(6):1009-20. Epub 2015 Jun 15.

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center Houston, Texas 77030 ; Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston Houston, Texas 77030 ; Center for Molecular Medicine, and Graduate Institute of Cancer Biology, China Medical University Taichung 404, Taiwan ; Department of Biotechnology, Asia University Taichung 413, Taiwan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532735PMC
August 2015

Modeling familial cancer with induced pluripotent stem cells.

Cell 2015 Apr;161(2):240-54

Department of Developmental and Regenerative Biology and The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.02.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397979PMC
April 2015

Activation of Keap1/Nrf2 signaling pathway by nuclear epidermal growth factor receptor in cancer cells.

Am J Transl Res 2014 22;6(6):649-63. Epub 2014 Nov 22.

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center 1515 Holcombe Boulevard, Houston, TX 77030 ; Graduate Institute for Cancer Biology and Center for Molecular Medicine, China Medical University Taichung 404, Taiwan ; Department of Biotechnology, Asia University Taichung, Taiwan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297334PMC
January 2015

Expression of metastasis suppressor BRMS1 in breast cancer cells results in a marked delay in cellular adhesion to matrix.

Mol Carcinog 2014 Dec 2;53(12):1011-26. Epub 2013 Sep 2.

Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1002/mc.22068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939074PMC
December 2014

EGFR modulates DNA synthesis and repair through Tyr phosphorylation of histone H4.

Dev Cell 2014 Jul;30(2):224-37

Graduate Institute of Cancer Biology and Center for Molecular Medicine, China Medical University, Taichung 404, Taiwan; Department of Biotechnology, Asia University, Taichung 413, Taiwan; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2014.06.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149291PMC
July 2014

MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer.

Sci Signal 2014 Jul 29;7(336):ra71. Epub 2014 Jul 29.

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX 77030, USA. Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University, Taichung 404, Taiwan. Department of Biotechnology, Asia University, Taichung 413, Taiwan.

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http://dx.doi.org/10.1126/scisignal.2005076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161976PMC
July 2014

S6K1 promotes invasiveness of breast cancer cells in a model of metastasis of triple-negative breast cancer.

Am J Transl Res 2014 18;6(4):361-76. Epub 2014 Jul 18.

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center Houston, Texas ; The University of Texas Graduate School of Biomedical Sciences at Houston Houston, Texas ; Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University Taichung 402, Taiwan ; Department of Biotechnology, Asia University Taichung, Taiwan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113498PMC
July 2014

Inhibition of type I insulin-like growth factor receptor signaling attenuates the development of breast cancer brain metastasis.

PLoS One 2013 5;8(9):e73406. Epub 2013 Sep 5.

Department of Molecular and Cellular Oncology, the University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America ; Cancer Biology Program, the University of Texas Graduate School of Biomedical Sciences at Houston, Houston, Texas, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0073406PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764163PMC
June 2014

TIG1 promotes the development and progression of inflammatory breast cancer through activation of Axl kinase.

Cancer Res 2013 Nov 6;73(21):6516-25. Epub 2013 Sep 6.

Authors' Affiliations: Department of Breast Medical Oncology, Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, Departments of Molecular and Cellular Oncology, Pathology, Radiation Oncology, and Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas; Tolero Pharmaceuticals, Inc., Salt Lake City, Utah; and Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University, Taichung, Taiwan.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-0967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135947PMC
November 2013

EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2.

Nature 2013 May 1;497(7449):383-7. Epub 2013 May 1.

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1038/nature12080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717558PMC
May 2013

SRC-3 coactivator regulates cell resistance to cytotoxic stress via TRAF4-mediated p53 destabilization.

Genes Dev 2013 Feb;27(3):274-87

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1101/gad.203760.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576513PMC
February 2013

The role of p27(Kip1) in dasatinib-enhanced paclitaxel cytotoxicity in human ovarian cancer cells.

J Natl Cancer Inst 2011 Sep 2;103(18):1403-22. Epub 2011 Aug 2.

Department of Experimental Therapeutics, the University of Texas M. D. Anderson Cancer Center, Unit 354, Rm Y6.5343, 1515 Holcombe Blvd, Houston, TX, USA.

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http://dx.doi.org/10.1093/jnci/djr280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176777PMC
September 2011

p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs.

Nat Cell Biol 2011 Mar 20;13(3):317-23. Epub 2011 Feb 20.

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1038/ncb2173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075845PMC
March 2011

EZH2 promotes expansion of breast tumor initiating cells through activation of RAF1-β-catenin signaling.

Cancer Cell 2011 Jan 6;19(1):86-100. Epub 2011 Jan 6.

Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.ccr.2010.10.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041516PMC
January 2011

Activation of p21(CIP1/WAF1) in mammary epithelium accelerates mammary tumorigenesis and promotes lung metastasis.

Biochem Biophys Res Commun 2010 Dec 30;403(1):103-7. Epub 2010 Oct 30.

Department of Molecular and Cellular Oncology, The University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.bbrc.2010.10.126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001223PMC
December 2010

TRIM24 links a non-canonical histone signature to breast cancer.

Nature 2010 Dec;468(7326):927-32

Department of Biochemistry and Molecular Biology, Program in Genes and Development, Graduate School of Biomedical Sciences, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1038/nature09542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058826PMC
December 2010

RNA helicase A is a DNA-binding partner for EGFR-mediated transcriptional activation in the nucleus.

Proc Natl Acad Sci U S A 2010 Sep 27;107(37):16125-30. Epub 2010 Aug 27.

Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1073/pnas.1000743107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941329PMC
September 2010

CXCR4 expression in early breast cancer and risk of distant recurrence.

Oncologist 2009 Dec 25;14(12):1182-8. Epub 2009 Nov 25.

Breast Medical Oncology Unit, Department of Radiation Therapy, Department of Pathology and Translational Research Unit (UPRES EA03535), Institut Gustave Roussy, University of Paris XI, Villejuif, France.

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http://dx.doi.org/10.1634/theoncologist.2009-0161DOI Listing
December 2009

Phosphorylation of ARD1 by IKKbeta contributes to its destabilization and degradation.

Biochem Biophys Res Commun 2009 Nov 28;389(1):156-61. Epub 2009 Aug 28.

Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X090170
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http://dx.doi.org/10.1016/j.bbrc.2009.08.127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753275PMC
November 2009

TNFalpha induces HIF-1alpha expression through activation of IKKbeta.

Biochem Biophys Res Commun 2009 Nov 17;389(4):640-4. Epub 2009 Sep 17.

Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X0901844
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http://dx.doi.org/10.1016/j.bbrc.2009.09.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762003PMC
November 2009

A novel hTERT promoter-driven E1A therapeutic for ovarian cancer.

Mol Cancer Ther 2009 Aug 11;8(8):2375-82. Epub 2009 Aug 11.

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-09-0056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759534PMC
August 2009

Nuclear expression of epidermal growth factor receptor is a novel prognostic value in patients with ovarian cancer.

Mol Carcinog 2009 Jul;48(7):610-7

Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://doi.wiley.com/10.1002/mc.20504
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http://dx.doi.org/10.1002/mc.20504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718429PMC
July 2009

Krüppel-like factor 8 induces epithelial to mesenchymal transition and epithelial cell invasion.

Cancer Res 2007 Aug;67(15):7184-93

Center for Cell Biology and Cancer Research, Albany Medical College, Albany, New York 12208, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-4729DOI Listing
August 2007

Targeted expression of BikDD eradicates pancreatic tumors in noninvasive imaging models.

Cancer Cell 2007 Jul;12(1):52-65

Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1016/j.ccr.2007.05.009DOI Listing
July 2007

Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization.

Mol Cell Biol 2007 Jun 26;27(11):4006-17. Epub 2007 Mar 26.

Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.00620-06
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http://dx.doi.org/10.1128/MCB.00620-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1900029PMC
June 2007

Myeloid cell leukemia-1 inversely correlates with glycogen synthase kinase-3beta activity and associates with poor prognosis in human breast cancer.

Cancer Res 2007 May 10;67(10):4564-71. Epub 2007 May 10.

Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, Usa.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-1788DOI Listing
May 2007

Tyrosine phosphorylation controls PCNA function through protein stability.

Nat Cell Biol 2006 Dec 19;8(12):1359-68. Epub 2006 Nov 19.

Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://ir.cmu.edu.tw/ir/bitstream/310903500/7091/3/Tyrosine+
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http://www.nature.com/doifinder/10.1038/ncb1501
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http://dx.doi.org/10.1038/ncb1501DOI Listing
December 2006

Cytoplasmic expression of p21CIP1/WAF1 is correlated with IKKbeta overexpression in human breast cancers.

Int J Oncol 2006 Nov;29(5):1103-10

Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.

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November 2006

MDM2 promotes cell motility and invasiveness by regulating E-cadherin degradation.

Mol Cell Biol 2006 Oct;26(19):7269-82

Department of Molecular and Cellular Oncology, University of Texas M. D. Anderson Cancer Center, Unit 108, Houston, TX 77030, USA.

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http://dx.doi.org/10.1128/MCB.00172-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1592879PMC
October 2006

Ionizing radiation activates expression of FOXO3a, Fas ligand, and Bim, and induces cell apoptosis.

Int J Oncol 2006 Sep;29(3):643-8

Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, 77030, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2632978PMC
September 2006

Nuclear translocation of the pro-apoptotic Bcl-2 family member Bok induces apoptosis.

Mol Carcinog 2006 Feb;45(2):73-83

Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Centre, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1002/mc.20156DOI Listing
February 2006

Gene therapy with E2F-1 up-regulates the protein kinase PKR and inhibits growth of leiomyosarcoma in vivo.

Mol Cancer Ther 2005 Nov;4(11):1710-6

Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Box 444, Houston, Texas 77030-4009, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-05-0036DOI Listing
November 2005

Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3.

Science 2005 Oct;310(5746):306-10

Department of Molecular and Cellular Oncology, the University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1118947
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October 2005

E1A sensitizes cancer cells to TRAIL-induced apoptosis through enhancement of caspase activation.

Mol Cancer Res 2005 Apr;3(4):219-26

Department of Molecular and Cellular Oncology, Unit 108, The University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-04-0084DOI Listing
April 2005

Novel prognostic value of nuclear epidermal growth factor receptor in breast cancer.

Cancer Res 2005 Jan;65(1):338-48

Department of Molecular and Cellular Oncology, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.

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January 2005

Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis.

Cancer Cell 2004 Nov;6(5):459-69

Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1016/j.ccr.2004.09.027DOI Listing
November 2004

Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition.

Nat Cell Biol 2004 Oct 26;6(10):931-40. Epub 2004 Sep 26.

Department of Molecular and Cellular Oncology, Breast Cancer Basic Research Program, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1038/ncb1173DOI Listing
October 2004

Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2.

Cancer Cell 2004 Sep;6(3):251-61

Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.ccr.2004.07.012DOI Listing
September 2004

Phosphorylation/cytoplasmic localization of p21Cip1/WAF1 is associated with HER2/neu overexpression and provides a novel combination predictor for poor prognosis in breast cancer patients.

Clin Cancer Res 2004 Jun;10(11):3815-24

Departments of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-03-0527DOI Listing
June 2004

IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a.

Cell 2004 Apr;117(2):225-37

Department of Molecular and Cellular Oncology, The University of Texas, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/s0092-8674(04)00302-2DOI Listing
April 2004

A delayed chemically induced tumorigenesis in Brca2 mutant mice.

Oncogene 2004 Mar;23(10):1896-901

Department of Molecular and Cellular Oncology, The University of Texas, Houston, TX, USA.

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http://dx.doi.org/10.1038/sj.onc.1207314DOI Listing
March 2004

Crossregulation of NF-kappaB by the APC/GSK-3beta/beta-catenin pathway.

Mol Carcinog 2004 Mar;39(3):139-46

Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1002/mc.10169DOI Listing
March 2004

Selective activation of ceruloplasmin promoter in ovarian tumors: potential use for gene therapy.

Cancer Res 2004 Mar;64(5):1788-93

Department of Gynecologic Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1158/0008-5472.can-03-2551DOI Listing
March 2004

STK15/Aurora-A expression in primary breast tumors is correlated with nuclear grade but not with prognosis.

Cancer 2004 Jan;100(1):12-9

Department of Breast Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://doi.wiley.com/10.1002/cncr.11879
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January 2004

Loss of aurora A/STK15/BTAK overexpression correlates with transition of in situ to invasive ductal carcinoma of the breast.

Cancer Epidemiol Biomarkers Prev 2003 Dec;12(12):1518-22

Department of Clinical Cancer Prevention, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

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December 2003

Prostate-specific antitumor activity by probasin promoter-directed p202 expression.

Mol Carcinog 2003 Jul;37(3):130-7

Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1002/mc.10129DOI Listing
July 2003

beta-catenin nuclear localization is associated with grade in ovarian serous carcinoma.

Gynecol Oncol 2003 Mar;88(3):363-8

Department of Gynecologic Oncology, University of Texas M. D. Anderson Cancer Center, TX 77030, Houston, USA

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http://dx.doi.org/10.1016/s0090-8258(02)00015-xDOI Listing
March 2003

Systemic gene therapy in human xenograft tumor models by liposomal delivery of the E1A gene.

Cancer Res 2002 Nov;62(22):6712-6

Breast Cancer Research Program Core Laboratory, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

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November 2002

Proapoptotic and antitumor activities of adenovirus-mediated p202 gene transfer.

Clin Cancer Res 2002 Oct;8(10):3290-7

Departments of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

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October 2002

beta-catenin interacts with and inhibits NF-kappa B in human colon and breast cancer.

Cancer Cell 2002 Oct;2(4):323-34

Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/s1535-6108(02)00154-xDOI Listing
October 2002