Publications

Co-overexpression of response regulator genes slr1037 and sll0039 improves tolerance of Synechocystis sp. PCC 6803 to 1-butanol.
Bioresour Technol 2017 Dec 4;245(Pt B):1476-1483. Epub 2017 May 4.
Laboratory of Synthetic Microbiology, School of Chemical Engineering & Technology, Tianjin University, Tianjin, PR China; Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, PR China; SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, PR China; Center for Biosafety Research and Strategy, Tianjin University, Tianjin, PR China.

Detergent-Insoluble Proteome Analysis Revealed Aberrantly Aggregated Proteins in Human Preeclampsia Placentas.
J Proteome Res 2017 Dec 17;16(12):4468-4480. Epub 2017 Oct 17.
Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University , 601 Huangpu Avenue West, Guangzhou, Guangdong 510632, China.

Screening and transcriptomic analysis of Crypthecodinium cohnii mutants with high growth and lipid content using the acetyl-CoA carboxylase inhibitor sethoxydim.
Appl Microbiol Biotechnol 2017 Aug 3;101(15):6179-6191. Epub 2017 Jul 3.
Laboratory of Synthetic Microbiology, School of Chemical Engineering & Technology, Tianjin University, Tianjin, 300072, People's Republic of China.

Metabolomic analysis and lipid accumulation in a glucose tolerant Crypthecodinium cohnii strain obtained by adaptive laboratory evolution.
Bioresour Technol 2017 Jul 12;235:87-95. Epub 2017 Mar 12.
Laboratory of Synthetic Microbiology, School of Chemical Engineering & Technology, Tianjin University, Tianjin 300072, PR China; Key Laboratory of Systems Bioengineering, Ministry of Education of China, Tianjin 300072, PR China; Collaborative Innovation Center of Chemical Science & Engineering, Tianjin, PR China; Center for Biosafety Research and Strategy, Tianjin University, Tianjin, PR China.

Transcriptional regulator PrqR plays a negative role in glucose metabolism and oxidative stress acclimation in Synechocystis sp. PCC 6803.
Sci Rep 2016 Sep 1;6:32507. Epub 2016 Sep 1.
Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200240, P.R. China.


Biosynthesis of platform chemical 3-hydroxypropionic acid (3-HP) directly from CO2 in cyanobacterium Synechocystis sp. PCC 6803.
Metab Eng 2016 Mar 9;34:60-70. Epub 2015 Nov 9.
Laboratory of Synthetic Microbiology, School of Chemical Engineering & Technology, Tianjin University, Tianjin 300072, P.R. China; Key Laboratory of Systems Bioengineering, Ministry of Education of China, Tianjin 300072, P.R. China; Synbio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, P.R. China. Electronic address:

Identification and metabolomic analysis of chemical modulators for lipid accumulation in Crypthecodinium cohnii.
Bioresour Technol 2015 Sep 18;191:362-8. Epub 2015 Mar 18.
Laboratory of Synthetic Microbiology, School of Chemical Engineering & Technology, Tianjin University, Tianjin 300072, PR China; Key Laboratory of Systems Bioengineering, Ministry of Education of China, Tianjin 300072, PR China; SynBio Platform, Collaborative Innovation Center of Chemical Science & Engineering, Tianjin, PR China. Electronic address:

A global network-based protocol for functional inference of hypothetical proteins in Synechocystis sp. PCC 6803.
J Microbiol Methods 2015 Sep 3;116:44-52. Epub 2015 Jul 3.
Laboratory of Synthetic Microbiology, School of Chemical Engineering & Technology, Tianjin University, Tianjin 300072, PR China; Key Laboratory of Systems Bioengineering, Ministry of Education of China, Tianjin 300072, PR China; SynBio Platform, Collaborative Innovation Center of Chemical Science & Engineering, Tianjin, PR China. Electronic address:

A transcriptional regulator Sll0794 regulates tolerance to biofuel ethanol in photosynthetic Synechocystis sp. PCC 6803.
Mol Cell Proteomics 2014 Dec 19;13(12):3519-32. Epub 2014 Sep 19.
From the ‡Laboratory of Synthetic Microbiology, School of Chemical Engineering & Technology, Tianjin University, Tianjin 300072, P.R. China; §Key Laboratory of Systems Bioengineering, Ministry of Education of China, Tianjin 300072, P.R. China; ¶Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, P.R. China;

Single-cell analysis reveals gene-expression heterogeneity in syntrophic dual-culture of Desulfovibrio vulgaris with Methanosarcina barkeri.
Sci Rep 2014 Dec 15;4:7478. Epub 2014 Dec 15.
1] Laboratory of Synthetic Microbiology, School of Chemical Engineering &Technology, Tianjin University, Tianjin 300072, P.R. China [2] Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin 300072, P.R. China [3] SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), 300072, P.R. China.

Metabolomic and network analysis of astaxanthin-producing Haematococcus pluvialis under various stress conditions.
Bioresour Technol 2014 Oct 10;170:522-529. Epub 2014 Aug 10.
Laboratory of Synthetic Microbiology, School of Chemical Engineering & Technology, Tianjin University, Tianjin 300072, PR China; Key Laboratory of Systems Bioengineering, Ministry of Education of China, Tianjin 300072, PR China; Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, PR China. Electronic address:

Integrated proteomic and metabolomic characterization of a novel two-component response regulator Slr1909 involved in acid tolerance in Synechocystis sp. PCC 6803.
J Proteomics 2014 Sep 3;109:76-89. Epub 2014 Jul 3.
Laboratory of Synthetic Microbiology, School of Chemical Engineering & Technology, Tianjin University, Tianjin 300072, PR China; Key Laboratory of Systems Bioengineering, Ministry of Education of China, Tianjin 300072, PR China; Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, PR China. Electronic address:

Engineering biofuel tolerance in non-native producing microorganisms.
Biotechnol Adv 2014 Mar-Apr;32(2):541-8. Epub 2014 Feb 13.
Laboratory of Synthetic Microbiology, School of Chemical Engineering & Technology, Tianjin University, Tianjin 300072, PR China; Key Laboratory of Systems Bioengineering, Ministry of Education, Tianjin 300072, PR China; Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, PR China. Electronic address:

Metabolomic analysis of the salt-sensitive mutants reveals changes in amino acid and fatty acid composition important to long-term salt stress in Synechocystis sp. PCC 6803.
Funct Integr Genomics 2014 Jun 19;14(2):431-40. Epub 2014 Mar 19.
Laboratory of Synthetic Microbiology, School of Chemical Engineering Technology, Tianjin University, Tianjin, 300072, People's Republic of China.

An orphan response regulator Sll0649 involved in cadmium tolerance and metal homeostasis in photosynthetic Synechocystis sp. PCC 6803.
J Proteomics 2014 May 3;103:87-102. Epub 2014 Apr 3.
Laboratory of Synthetic Microbiology, School of Chemical Engineering & Technology, Tianjin University, Tianjin 300072, PR China; Key Laboratory of Systems Bioengineering, Ministry of Education of China, Tianjin 300072, PR China; Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, PR China. Electronic address:

Identification of two-component system AfsQ1/Q2 regulon and its cross-regulation with GlnR in Streptomyces coelicolor.
Mol Microbiol 2013 Jan 19;87(1):30-48. Epub 2012 Nov 19.
Key Laboratory of Synthetic Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China.

Differential regulation of antibiotic biosynthesis by DraR-K, a novel two-component system in Streptomyces coelicolor.
Mol Microbiol 2012 Aug 21;85(3):535-56. Epub 2012 Jun 21.
Key Laboratory of Synthetic Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China.

An orphan histidine kinase, OhkA, regulates both secondary metabolism and morphological differentiation in Streptomyces coelicolor.
J Bacteriol 2011 Jun 22;193(12):3020-32. Epub 2011 Apr 22.
Key Laboratory of Synthetic Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, People's Republic of China.

Comparative genomic and transcriptomic analysis revealed genetic characteristics related to solvent formation and xylose utilization in Clostridium acetobutylicum EA 2018.
BMC Genomics 2011 Feb 2;12:93. Epub 2011 Feb 2.
Key Laboratory of Synthetic Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China.

Proteomic analysis of Ketogulonicigenium vulgare under glutathione reveals high demand for thiamin transport and antioxidant protection.
PLoS One 2012 22;7(2):e32156. Epub 2012 Feb 22.
Key Laboratory of Systems Bioengineering, Ministry of Education and Department of Pharmaceutical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, People's Republic of China.

Butanol tolerance regulated by a two-component response regulator Slr1037 in photosynthetic Synechocystis sp. PCC 6803.
Biotechnol Biofuels 2014 11;7:89. Epub 2014 Jun 11.
Laboratory of Synthetic Microbiology, School of Chemical Engineering & Technology, Tianjin University, Tianjin 300072, P.R. China ; Key Laboratory of Systems Bioengineering, Ministry of Education of China, Tianjin 300072, P.R. China ; Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, P.R. China.

Protein Network Signatures Associated with Exogenous Biofuels Treatments in Cyanobacterium Synechocystis sp. PCC 6803.
Front Bioeng Biotechnol 2014 3;2:48. Epub 2014 Nov 3.
Laboratory of Synthetic Microbiology, School of Chemical Engineering and Technology, Tianjin University , Tianjin , China ; Key Laboratory of Systems Bioengineering, Ministry of Education of China , Tianjin , China ; SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering , Tianjin , China.

Chemicals to enhance microalgal growth and accumulation of high-value bioproducts.
Front Microbiol 2015 17;6:56. Epub 2015 Feb 17.
Laboratory of Synthetic Microbiology, School of Chemical Engineering and Technology, Tianjin University Tianjin, China ; Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University Tianjin, China ; SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Tianjin, China.

Identification of a transporter Slr0982 involved in ethanol tolerance in cyanobacterium Synechocystis sp. PCC 6803.
Front Microbiol 2015 18;6:487. Epub 2015 May 18.
Laboratory of Synthetic Microbiology, School of Chemical Engineering and Technology, Tianjin University Tianjin, China ; Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University Tianjin, China ; SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Tianjin, China.

Heterologous xylose isomerase pathway and evolutionary engineering improve xylose utilization in Saccharomyces cerevisiae.
Front Microbiol 2015 21;6:1165. Epub 2015 Oct 21.
Key Laboratory of Systems Bioengineering, Ministry of Education, Tianjin University Tianjin, China ; SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), School of Chemical Engineering and Technology, Tianjin University Tianjin, China.

Comparison of Transcriptional Heterogeneity of Eight Genes between Batch Desulfovibrio vulgaris Biofilm and Planktonic Culture at a Single-Cell Level.
Front Microbiol 2016 27;7:597. Epub 2016 Apr 27.
Laboratory of Synthetic Microbiology, School of Chemical Engineering & Technology, Tianjin UniversityTianjin, China; Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin UniversityTianjin, China; SynBio Research Platform, Collaborative Innovation Center of Chemical Science and EngineeringTianjin, China.

Fatty acid and metabolomic profiling approaches differentiate heterotrophic and mixotrophic culture conditions in a microalgal food supplement 'Euglena'.
BMC Biotechnol 2016 06 2;16(1):49. Epub 2016 Jun 2.
Shenzhen Key Laboratory of Marine Bioresource & Eco-environmental Science, Shenzhen Engineering Laboratory for Marine Algal Biotechnology, College of Life Science, Shenzhen University, Shenzhen, 518060, People's Republic of China.

Roles of two-component system AfsQ1/Q2 in regulating biosynthesis of the yellow-pigmented coelimycin P2 in Streptomyces coelicolor.
FEMS Microbiol Lett 2016 08 15;363(15). Epub 2016 Jun 15.
Key Laboratory of Synthetic Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 300 Fenglin Road, Shanghai 200032, PR China Shanghai Collaborative Innovation Center for Biomanufacturing Technology, Shanghai 200237, PR China

Proteomic and metabolomic analyses reveal metabolic responses to 3-hydroxypropionic acid synthesized internally in cyanobacteriumsp. PCC 6803.
Biotechnol Biofuels 2016 6;9:209. Epub 2016 Oct 6.
Laboratory of Synthetic Microbiology, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072 People's Republic of China ; Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, People's Republic of China ; SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin, People's Republic of China.

Functional Diversity of Transcriptional Regulators in the Cyanobacteriumsp. PCC 6803.
Front Microbiol 2017 21;8:280. Epub 2017 Feb 21.
Laboratory of Synthetic Microbiology, School of Chemical Engineering and Technology, Tianjin UniversityTianjin, China; Key Laboratory of Systems Bioengineering - Ministry of Education, Tianjin UniversityTianjin, China; SynBio Research Platform, Collaborative Innovation Center of Chemical Science and EngineeringTianjin, China; Center for Biosafety Research and Strategy, Tianjin UniversityTianjin, China.


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