Publications by authors named "Weiru Wang"

67Publications

Hematopoietic Progenitor Kinase-1 Structure in a Domain-Swapped Dimer.

Structure 2019 01 29;27(1):125-133.e4. Epub 2018 Nov 29.

Department of Structural Biology, Genentech, South San Francisco, CA 94080, USA. Electronic address:

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http://dx.doi.org/10.1016/j.str.2018.10.025DOI Listing
January 2019

ERK Mutations and Amplification Confer Resistance to ERK-Inhibitor Therapy.

Clin Cancer Res 2018 08 14;24(16):4044-4055. Epub 2018 May 14.

Molecular Biology Department, Genentech Inc., South San Francisco, California.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-17-3674DOI Listing
August 2018

Unsaturated fatty acyl recognition by Frizzled receptors mediates dimerization upon Wnt ligand binding.

Proc Natl Acad Sci U S A 2017 04 4;114(16):4147-4152. Epub 2017 Apr 4.

Department of Early Discovery Biochemistry, Genentech, South San Francisco, CA 94080;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1618293114
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http://dx.doi.org/10.1073/pnas.1618293114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402412PMC
April 2017

Association between the incidence of varicella and meteorological conditions in Jinan, Eastern China, 2012-2014.

BMC Infect Dis 2016 Apr 22;16:179. Epub 2016 Apr 22.

Jinan Center for Disease Control and Prevention, Shandong Province, 250021, P. R. China.

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http://dx.doi.org/10.1186/s12879-016-1507-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840874PMC
April 2016

Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors.

Bioorg Med Chem Lett 2015 Nov 22;25(21):4728-4732. Epub 2015 Aug 22.

Department of Computational Chemistry, Genentech, Inc., South San Francisco, CA 94080, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X150088
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http://dx.doi.org/10.1016/j.bmcl.2015.08.048DOI Listing
November 2015

Structure-Guided Design of Group I Selective p21-Activated Kinase Inhibitors.

J Med Chem 2015 Jun 12;58(12):5121-36. Epub 2015 Jun 12.

#Shanghai Chempartner Inc., 998 Halei Road, Zhangjiang Hi-Tech Park, Pudong New Area, Shanghai 201203, People's Republic of China.

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http://dx.doi.org/10.1021/acs.jmedchem.5b00572DOI Listing
June 2015

Regulation of the oncoprotein Smoothened by small molecules.

Nat Chem Biol 2015 Apr;11(4):246-55

Department of Molecular Oncology, Genentech Inc., San Francisco, California, USA.

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http://dx.doi.org/10.1038/nchembio.1776DOI Listing
April 2015

Inhibitors of p21-activated kinases (PAKs).

J Med Chem 2015 Jan 3;58(1):111-29. Epub 2014 Dec 3.

Discovery Chemistry, and ‡Structural Biology, Genentech , 1 DNA Way, South San Francisco, California 94080, United States.

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http://dx.doi.org/10.1021/jm501613qDOI Listing
January 2015

Dimerization of the kinase ARAF promotes MAPK pathway activation and cell migration.

Sci Signal 2014 Aug 5;7(337):ra73. Epub 2014 Aug 5.

Cell death signalling group, Institute of Biochemistry II, Goethe University Medical School, Frankfurt 60590, Germany. Institute for Immunology, University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstraße 1, Building 708, Mainz 55131, Germany.

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http://dx.doi.org/10.1126/scisignal.2005484DOI Listing
August 2014

Structural and biochemical analyses of the catalysis and potency impact of inhibitor phosphoribosylation by human nicotinamide phosphoribosyltransferase.

Chembiochem 2014 May 5;15(8):1121-30. Epub 2014 May 5.

Genentech, Inc., Department of Structural Biology, 1 DNA Way, South San Francisco, California 94080 (USA).

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http://dx.doi.org/10.1002/cbic.201402023DOI Listing
May 2014

Photoinduced bending behavior of cross-linked azobenzene liquid-crystalline polymer films with a poly(oxyethylene) backbone.

Macromol Rapid Commun 2014 Jul 28;35(14):1266-72. Epub 2014 Apr 28.

Department of Materials Science & State Key Laboratory of Molecular Engineering of Polymers, Fudan University, 220 Handan Road, Shanghai, 200433, China.

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http://dx.doi.org/10.1002/marc.201400112DOI Listing
July 2014

Characterization of oxidative carbonylation on recombinant monoclonal antibodies.

Anal Chem 2014 May 30;86(10):4799-806. Epub 2014 Apr 30.

Protein Analytical Chemistry, ‡X-ray Laboratory, Genentech Inc. , South San Francisco, California 94080, United States.

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http://dx.doi.org/10.1021/ac4039866DOI Listing
May 2014

High-throughput detection of clinically relevant mutations in archived tumor samples by multiplexed PCR and next-generation sequencing.

Clin Cancer Res 2014 Apr 26;20(8):2080-91. Epub 2014 Feb 26.

Authors' Affiliations: Departments of Oncology Biomarker Development, Bioinformatics, Structural Biology, and Pathology, Genentech, Inc.; Fluidigm Inc., South San Francisco, California; and Expression Analysis, Durham, North Carolina.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-3114DOI Listing
April 2014

Back pocket flexibility provides group II p21-activated kinase (PAK) selectivity for type I 1/2 kinase inhibitors.

J Med Chem 2014 Feb 4;57(3):1033-45. Epub 2014 Feb 4.

Department of Discovery Chemistry, ‡Department of Translational Oncology, △Department of Pathology, §Department of Drug Metabolism and Pharmacokinetics, ∥Department of Biochemical and Cellular Pharmacology, and ⊥Department of Structural Biology, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.

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http://dx.doi.org/10.1021/jm401768tDOI Listing
February 2014

Targeting protein-protein interaction by small molecules.

Annu Rev Pharmacol Toxicol 2014 21;54:435-56. Epub 2013 Oct 21.

Discovery Oncology and.

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http://dx.doi.org/10.1146/annurev-pharmtox-011613-140028DOI Listing
September 2014

Allosteric inhibition of BACE1 by an exosite-binding antibody.

Curr Opin Struct Biol 2013 Dec 30;23(6):797-805. Epub 2013 Aug 30.

Department of Structural Biology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States. Electronic address:

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http://dx.doi.org/10.1016/j.sbi.2013.08.001DOI Listing
December 2013

NMR study to identify a ligand-binding pocket in Ras.

Enzymes 2013 8;33 Pt A:15-39. Epub 2013 Aug 8.

Department of Structural Biology, Genentech Inc., One DNA Way, South San Francisco, California, USA. Electronic address:

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http://dx.doi.org/10.1016/B978-0-12-416749-0.00002-6DOI Listing
August 2014

Ras inhibition via direct Ras binding--is there a path forward?

Bioorg Med Chem Lett 2012 Sep 2;22(18):5766-76. Epub 2012 Aug 2.

Structural Biology, Genentech, Inc., One DNA Way, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1016/j.bmcl.2012.07.082DOI Listing
September 2012

Wnt antagonists bind through a short peptide to the first β-propeller domain of LRP5/6.

Structure 2011 Oct 22;19(10):1433-42. Epub 2011 Sep 22.

Department of Early Discovery Biochemistry, Genentech Research and Early Development, 1 DNA Way, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1016/j.str.2011.07.005DOI Listing
October 2011

Novel multisubstrate inhibitors of mammalian purine nucleoside phosphorylase.

Acta Crystallogr D Biol Crystallogr 2005 Nov 19;61(Pt 11):1449-58. Epub 2005 Oct 19.

Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA.

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http://scripts.iucr.org/cgi-bin/paper?S0907444905025503
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http://dx.doi.org/10.1107/S0907444905025503DOI Listing
November 2005

Crystal structure of flavin binding to FAD synthetase of Thermotoga maritima.

Proteins 2005 Jan;58(1):246-8

Berkeley Structural Genomics Center, Physical Biosciences Division of the Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.

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http://doi.wiley.com/10.1002/prot.20207
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http://dx.doi.org/10.1002/prot.20207DOI Listing
January 2005

Crystal structure of tRNA (m1G37) methyltransferase from Aquifex aeolicus at 2.6 A resolution: a novel methyltransferase fold.

Proteins 2003 Nov;53(2):326-8

Department of Chemistry, University of California, Berkeley, California, USA.

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http://dx.doi.org/10.1002/prot.10479DOI Listing
November 2003

Crystal structure of a flavin-binding protein from Thermotoga maritima.

Proteins 2003 Sep;52(4):633-5

Physical Biosciences Division of the Lawrence Berkeley National Laboratory, Berkeley, California, USA.

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http://dx.doi.org/10.1002/prot.10353DOI Listing
September 2003

Dynamic and clustering model of bacterial chemotaxis receptors: structural basis for signaling and high sensitivity.

Proc Natl Acad Sci U S A 2002 Sep 19;99(18):11611-5. Epub 2002 Aug 19.

Department of Chemistry and E. O. Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA.

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http://dx.doi.org/10.1073/pnas.132376499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC129317PMC
September 2002