Publications by authors named "Weining Lu"

33 Publications

Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations.

Authors:
Dervla M Connaughton Rufeng Dai Danielle J Owen Jonathan Marquez Nina Mann Adda L Graham-Paquin Makiko Nakayama Etienne Coyaud Estelle M N Laurent Jonathan R St-Germain Lot Snijders Blok Arianna Vino Verena Klämbt Konstantin Deutsch Chen-Han Wilfred Wu Caroline M Kolvenbach Franziska Kause Isabel Ottlewski Ronen Schneider Thomas M Kitzler Amar J Majmundar Florian Buerger Ana C Onuchic-Whitford Mao Youying Amy Kolb Daanya Salmanullah Evan Chen Amelie T van der Ven Jia Rao Hadas Ityel Steve Seltzsam Johanna M Rieke Jing Chen Asaf Vivante Daw-Yang Hwang Stefan Kohl Gabriel C Dworschak Tobias Hermle Mariëlle Alders Tobias Bartolomaeus Stuart B Bauer Michelle A Baum Eva H Brilstra Thomas D Challman Jacob Zyskind Carrie E Costin Katrina M Dipple Floor A Duijkers Marcia Ferguson David R Fitzpatrick Roger Fick Ian A Glass Peter J Hulick Antonie D Kline Ilona Krey Selvin Kumar Weining Lu Elysa J Marco Ingrid M Wentzensen Heather C Mefford Konrad Platzer Inna S Povolotskaya Juliann M Savatt Natalia V Shcherbakova Prabha Senguttuvan Audrey E Squire Deborah R Stein Isabelle Thiffault Victoria Y Voinova Michael J G Somers Michael A Ferguson Avram Z Traum Ghaleb H Daouk Ankana Daga Nancy M Rodig Paulien A Terhal Ellen van Binsbergen Loai A Eid Velibor Tasic Hila Milo Rasouly Tze Y Lim Dina F Ahram Ali G Gharavi Heiko M Reutter Heidi L Rehm Daniel G MacArthur Monkol Lek Kristen M Laricchia Richard P Lifton Hong Xu Shrikant M Mane Simone Sanna-Cherchi Andrew D Sharrocks Brian Raught Simon E Fisher Maxime Bouchard Mustafa K Khokha Shirlee Shril Friedhelm Hildebrandt

Am J Hum Genet 2020 10 4;107(4):727-742. Epub 2020 Sep 4.

Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

View Article and Find Full Text PDF
October 2020

Loss of Roundabout Guidance Receptor 2 (Robo2) in Podocytes Protects Adult Mice from Glomerular Injury by Maintaining Podocyte Foot Process Structure.

Authors:
Anna Pisarek-Horowitz Xueping Fan Sudhir Kumar Hila M Rasouly Richa Sharma Hui Chen Kathryn Coser Crystal T Bluette Dinesh Hirenallur-Shanthappa Sarah R Anderson Hongying Yang Laurence H Beck Ramon G Bonegio Joel M Henderson Stephen P Berasi David J Salant Weining Lu

Am J Pathol 2020 04 24;190(4):799-816. Epub 2020 Mar 24.

Renal Section, Department of Medicine, Boston University School of Medicine, Boston Medical Center, Boston, Massachusetts; Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston Medical Center, Boston, Massachusetts. Electronic address:

View Article and Find Full Text PDF
April 2020

Integrin-Linked Kinase Deficiency in Collecting Duct Principal Cell Promotes Necroptosis of Principal Cell and Contributes to Kidney Inflammation and Fibrosis.

Authors:
Ming Huang Shuai Zhu Huihui Huang Jinzhao He Kenji Tsuji William W Jin Dongping Xie Onju Ham Diane E Capen Weining Lu Teodor G Păunescu Baoxue Yang Hua A Jenny Lu

J Am Soc Nephrol 2019 11 25;30(11):2073-2090. Epub 2019 Oct 25.

Center for Systems Biology, Program in Membrane Biology, Division of Nephrology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts;

View Article and Find Full Text PDF
November 2019

Whole-Exome Sequencing Identifies Causative Mutations in Families with Congenital Anomalies of the Kidney and Urinary Tract.

Authors:
Amelie T van der Ven Dervla M Connaughton Hadas Ityel Nina Mann Makiko Nakayama Jing Chen Asaf Vivante Daw-Yang Hwang Julian Schulz Daniela A Braun Johanna Magdalena Schmidt David Schapiro Ronen Schneider Jillian K Warejko Ankana Daga Amar J Majmundar Weizhen Tan Tilman Jobst-Schwan Tobias Hermle Eugen Widmeier Shazia Ashraf Ali Amar Charlotte A Hoogstraaten Hannah Hugo Thomas M Kitzler Franziska Kause Caroline M Kolvenbach Rufeng Dai Leslie Spaneas Kassaundra Amann Deborah R Stein Michelle A Baum Michael J G Somers Nancy M Rodig Michael A Ferguson Avram Z Traum Ghaleb H Daouk Radovan Bogdanović Natasa Stajić Neveen A Soliman Jameela A Kari Sherif El Desoky Hanan M Fathy Danko Milosevic Muna Al-Saffar Hazem S Awad Loai A Eid Aravind Selvin Prabha Senguttuvan Simone Sanna-Cherchi Heidi L Rehm Daniel G MacArthur Monkol Lek Kristen M Laricchia Michael W Wilson Shrikant M Mane Richard P Lifton Richard S Lee Stuart B Bauer Weining Lu Heiko M Reutter Velibor Tasic Shirlee Shril Friedhelm Hildebrandt

J Am Soc Nephrol 2018 09 24;29(9):2348-2361. Epub 2018 Aug 24.

Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts;

View Article and Find Full Text PDF
September 2018

A homozygous missense variant in VWA2, encoding an interactor of the Fraser-complex, in a patient with vesicoureteral reflux.

Authors:
Amelie T van der Ven Birgit Kobbe Stefan Kohl Shirlee Shril Hans-Martin Pogoda Thomas Imhof Hadas Ityel Asaf Vivante Jing Chen Daw-Yang Hwang Dervla M Connaughton Nina Mann Eugen Widmeier Mary Taglienti Johanna Magdalena Schmidt Makiko Nakayama Prabha Senguttuvan Selvin Kumar Velibor Tasic Elijah O Kehinde Shrikant M Mane Richard P Lifton Neveen Soliman Weining Lu Stuart B Bauer Matthias Hammerschmidt Raimund Wagener Friedhelm Hildebrandt

PLoS One 2018 19;13(1):e0191224. Epub 2018 Jan 19.

Division of Nephrology, Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.

View Article and Find Full Text PDF
February 2018

Identification of direct negative cross-talk between the SLIT2 and bone morphogenetic protein-Gremlin signaling pathways.

Authors:
Kathleen E Tumelty Nathan Higginson-Scott Xueping Fan Piyush Bajaj Kelly M Knowlton Michael Shamashkin Anthony J Coyle Weining Lu Stephen P Berasi

J Biol Chem 2018 03 9;293(9):3039-3055. Epub 2018 Jan 9.

From the Centers for Therapeutic Innovation, Pfizer Inc., Cambridge, Massachusetts 02139,

View Article and Find Full Text PDF
March 2018

Unsupervised Sequential Outlier Detection With Deep Architectures.

Authors:
Weining Lu Yu Cheng Cao Xiao Shiyu Chang Shuai Huang Bin Liang Thomas Huang

IEEE Trans Image Process 2017 Sep 7;26(9):4321-4330. Epub 2017 Jun 7.

View Article and Find Full Text PDF
September 2017

Roundabout receptor 2 maintains inhibitory control of the adult midbrain.

Authors:
Bryan B Gore Samara M Miller Yong Sang Jo Madison A Baird Mrinalini Hoon Christina A Sanford Avery Hunker Weining Lu Rachel O Wong Larry S Zweifel

Elife 2017 04 10;6. Epub 2017 Apr 10.

Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, United States.

View Article and Find Full Text PDF
April 2017

A Dominant Mutation in Nuclear Receptor Interacting Protein 1 Causes Urinary Tract Malformations Dysregulation of Retinoic Acid Signaling.

Authors:
Asaf Vivante Nina Mann Hagith Yonath Anna-Carina Weiss Maike Getwan Michael M Kaminski Tobias Bohnenpoll Catherine Teyssier Jing Chen Shirlee Shril Amelie T van der Ven Hadas Ityel Johanna Magdalena Schmidt Eugen Widmeier Stuart B Bauer Simone Sanna-Cherchi Ali G Gharavi Weining Lu Daniella Magen Rachel Shukrun Richard P Lifton Velibor Tasic Horia C Stanescu Vincent Cavaillès Robert Kleta Yair Anikster Benjamin Dekel Andreas Kispert Soeren S Lienkamp Friedhelm Hildebrandt

J Am Soc Nephrol 2017 Aug 5;28(8):2364-2376. Epub 2017 Apr 5.

Departments of Medicine and

View Article and Find Full Text PDF
August 2017

SLIT2/ROBO2 signaling pathway inhibits nonmuscle myosin IIA activity and destabilizes kidney podocyte adhesion.

Authors:
Xueping Fan Hongying Yang Sudhir Kumar Kathleen E Tumelty Anna Pisarek-Horowitz Hila Milo Rasouly Richa Sharma Stefanie Chan Edyta Tyminski Michael Shamashkin Mostafa Belghasem Joel M Henderson Anthony J Coyle David J Salant Stephen P Berasi Weining Lu

JCI Insight 2016 Nov 17;1(19):e86934. Epub 2016 Nov 17.

Renal Section, Department of Medicine, Boston University Medical Center, Boston, Massachusetts, USA.

View Article and Find Full Text PDF
November 2016

Blocking peptides and molecular mimicry as treatment for kidney disease.

Authors:
Andrea Havasi Weining Lu Herbert T Cohen Laurence Beck Zhiyong Wang Chinaemare Igwebuike Steven C Borkan

Am J Physiol Renal Physiol 2017 06 21;312(6):F1016-F1025. Epub 2016 Sep 21.

Renal Section, Boston University Medical Center, Boston, Massachusetts

View Article and Find Full Text PDF
June 2017

Loss of Zeb2 in mesenchyme-derived nephrons causes primary glomerulocystic disease.

Authors:
Hila Milo Rasouly Sudhir Kumar Stefanie Chan Anna Pisarek-Horowitz Richa Sharma Qiongchao J Xi Yuriko Nishizaki Yujiro Higashi David J Salant Richard L Maas Weining Lu

Kidney Int 2016 12 31;90(6):1262-1273. Epub 2016 Aug 31.

Renal Section, Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts, USA; Graduate Program in Genomics and Genetics, Division of Graduate Medical Sciences, Boston University School of Medicine, Boston, Massachusetts, USA. Electronic address:

View Article and Find Full Text PDF
December 2016

Crim1 regulates integrin signaling in murine lens development.

Authors:
Ying Zhang Jieqing Fan Joshua W K Ho Tommy Hu Stephen C Kneeland Xueping Fan Qiongchao Xi Michael A Sellarole Wilhelmine N de Vries Weining Lu Salil A Lachke Richard A Lang Simon W M John Richard L Maas

Development 2016 Jan 17;143(2):356-66. Epub 2015 Dec 17.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA

View Article and Find Full Text PDF
January 2016

Mutations in TBX18 Cause Dominant Urinary Tract Malformations via Transcriptional Dysregulation of Ureter Development.

Authors:
Asaf Vivante Marc-Jens Kleppa Julian Schulz Stefan Kohl Amita Sharma Jing Chen Shirlee Shril Daw-Yang Hwang Anna-Carina Weiss Michael M Kaminski Rachel Shukrun Markus J Kemper Anja Lehnhardt Rolf Beetz Simone Sanna-Cherchi Miguel Verbitsky Ali G Gharavi Helen M Stuart Sally A Feather Judith A Goodship Timothy H J Goodship Adrian S Woolf Sjirk J Westra Daniel P Doody Stuart B Bauer Richard S Lee Rosalyn M Adam Weining Lu Heiko M Reutter Elijah O Kehinde Erika J Mancini Richard P Lifton Velibor Tasic Soeren S Lienkamp Harald Jüppner Andreas Kispert Friedhelm Hildebrandt

Am J Hum Genet 2015 Aug 30;97(2):291-301. Epub 2015 Jul 30.

Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA; Howard Hughes Medical Institute. Electronic address:

View Article and Find Full Text PDF
August 2015

Mutations of the SLIT2-ROBO2 pathway genes SLIT2 and SRGAP1 confer risk for congenital anomalies of the kidney and urinary tract.

Authors:
Daw-Yang Hwang Stefan Kohl Xueping Fan Asaf Vivante Stefanie Chan Gabriel C Dworschak Julian Schulz Albertien M van Eerde Alina C Hilger Heon Yung Gee Tracie Pennimpede Bernhard G Herrmann Glenn van de Hoek Kirsten Y Renkema Christoph Schell Tobias B Huber Heiko M Reutter Neveen A Soliman Natasa Stajic Radovan Bogdanovic Elijah O Kehinde Richard P Lifton Velibor Tasic Weining Lu Friedhelm Hildebrandt

Hum Genet 2015 Aug 31;134(8):905-16. Epub 2015 May 31.

Division of Nephrology, Department of Medicine, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA, 02115, USA.

View Article and Find Full Text PDF
August 2015

MATR3 disruption in human and mouse associated with bicuspid aortic valve, aortic coarctation and patent ductus arteriosus.

Authors:
Fabiola Quintero-Rivera Qiongchao J Xi Kim M Keppler-Noreuil Ji Hyun Lee Anne W Higgins Raymond M Anchan Amy E Roberts Ihn Sik Seong Xueping Fan Kasper Lage Lily Y Lu Joanna Tao Xuchen Hu Ronald Berezney Bruce D Gelb Anna Kamp Ivan P Moskowitz Ronald V Lacro Weining Lu Cynthia C Morton James F Gusella Richard L Maas

Hum Mol Genet 2015 Apr 7;24(8):2375-89. Epub 2015 Jan 7.

Division of Genetics, Department of Medicine,

View Article and Find Full Text PDF
April 2015

Vision-based pose estimation from points with unknown correspondences.

Authors:
Haoyin Zhou Tao Zhang Weining Lu

IEEE Trans Image Process 2014 Aug 9;23(8):3468-77. Epub 2014 Jun 9.

View Article and Find Full Text PDF
August 2014

Lower urinary tract development and disease.

Authors:
Hila Milo Rasouly Weining Lu

Wiley Interdiscip Rev Syst Biol Med 2013 May-Jun;5(3):307-42. Epub 2013 Feb 13.

Renal Section, Department of Medicine, Boston University Medical Center, Boston, MA, USA.

View Article and Find Full Text PDF
September 2013

Inhibitory effects of Robo2 on nephrin: a crosstalk between positive and negative signals regulating podocyte structure.

Authors:
Xueping Fan Qinggang Li Anna Pisarek-Horowitz Hila Milo Rasouly Xiangling Wang Ramon G Bonegio Hang Wang Margaret McLaughlin Steve Mangos Raghu Kalluri Lawrence B Holzman Iain A Drummond Dennis Brown David J Salant Weining Lu

Cell Rep 2012 Jul 12;2(1):52-61. Epub 2012 Jul 12.

Renal Section, Department of Medicine, Boston University Medical Center, Boston, MA 02118, USA.

View Article and Find Full Text PDF
July 2012

Noninvasive assessment of antenatal hydronephrosis in mice reveals a critical role for Robo2 in maintaining anti-reflux mechanism.

Authors:
Hang Wang Qinggang Li Juan Liu Cathy Mendelsohn David J Salant Weining Lu

PLoS One 2011 20;6(9):e24763. Epub 2011 Sep 20.

Renal Section, Department of Medicine, Boston University Medical Center, Boston, Massachusetts, United States of America.

View Article and Find Full Text PDF
January 2012

Assessing vesicoureteral reflux in live inbred mice via ultrasound with a microbubble contrast agent.

Authors:
Jose Paredes Sunder Sims-Lucas Hang Wang Weining Lu Brian Coley George K Gittes Carlton M Bates

Am J Physiol Renal Physiol 2011 May 16;300(5):F1262-5. Epub 2011 Feb 16.

Rangos Research Center, Pittsburgh, Pennsylvania, USA.

View Article and Find Full Text PDF
May 2011

The fate of Notch-deficient nephrogenic progenitor cells during metanephric kidney development.

Authors:
Ramon G B Bonegio Laurence H Beck Roopkiranjot K Kahlon Weining Lu David J Salant

Kidney Int 2011 May 26;79(10):1099-112. Epub 2011 Jan 26.

Renal Section, Department of Medicine, Boston University Medical Center, Boston, Massachusetts 02118, USA.

View Article and Find Full Text PDF
May 2011

Characterization of apparently balanced chromosomal rearrangements from the developmental genome anatomy project.

Authors:
Anne W Higgins Fowzan S Alkuraya Amy F Bosco Kerry K Brown Gail A P Bruns Diana J Donovan Robert Eisenman Yanli Fan Chantal G Farra Heather L Ferguson James F Gusella David J Harris Steven R Herrick Chantal Kelly Hyung-Goo Kim Shotaro Kishikawa Bruce R Korf Shashikant Kulkarni Eric Lally Natalia T Leach Emma Lemyre Janine Lewis Azra H Ligon Weining Lu Richard L Maas Marcy E MacDonald Steven D P Moore Roxanna E Peters Bradley J Quade Fabiola Quintero-Rivera Irfan Saadi Yiping Shen Jay Shendure Robin E Williamson Cynthia C Morton

Am J Hum Genet 2008 Mar;82(3):712-22

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

View Article and Find Full Text PDF
March 2008

NFIA haploinsufficiency is associated with a CNS malformation syndrome and urinary tract defects.

Authors:
Weining Lu Fabiola Quintero-Rivera Yanli Fan Fowzan S Alkuraya Diana J Donovan Qiongchao Xi Annick Turbe-Doan Qing-Gang Li Craig G Campbell Alan L Shanske Elliott H Sherr Ayesha Ahmad Roxana Peters Benedict Rilliet Paloma Parvex Alexander G Bassuk David J Harris Heather Ferguson Chantal Kelly Christopher A Walsh Richard M Gronostajski Koenraad Devriendt Anne Higgins Azra H Ligon Bradley J Quade Cynthia C Morton James F Gusella Richard L Maas

PLoS Genet 2007 May;3(5):e80

Genetics Division, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.

View Article and Find Full Text PDF
May 2007

Disruption of diacylglycerol kinase delta (DGKD) associated with seizures in humans and mice.

Authors:
Natalia T Leach Yi Sun Sebastien Michaud Yi Zheng Keith L Ligon Azra H Ligon Thomas Sander Bruce R Korf Weining Lu David J Harris James F Gusella Richard L Maas Bradley J Quade Andrew J Cole Max B Kelz Cynthia C Morton

Am J Hum Genet 2007 Apr 12;80(4):792-9. Epub 2007 Feb 12.

Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

View Article and Find Full Text PDF
April 2007

Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux.

Authors:
Weining Lu Albertien M van Eerde Xueping Fan Fabiola Quintero-Rivera Shashikant Kulkarni Heather Ferguson Hyung-Goo Kim Yanli Fan Qiongchao Xi Qing-Gang Li Damien Sanlaville William Andrews Vasi Sundaresan Weimin Bi Jiong Yan Jacques C Giltay Cisca Wijmenga Tom P V M de Jong Sally A Feather Adrian S Woolf Yi Rao James R Lupski Michael R Eccles Bradley J Quade James F Gusella Cynthia C Morton Richard L Maas

Am J Hum Genet 2007 Apr 14;80(4):616-32. Epub 2007 Feb 14.

Genetics Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

View Article and Find Full Text PDF
April 2007

Inhibition of HER-2(neu/ErbB2) restores normal function and structure to polycystic kidney disease (PKD) epithelia.

Authors:
Samantha J Wilson Kurt Amsler Deborah P Hyink Xiaohong Li Weining Lu Jing Zhou Christopher R Burrow Patricia D Wilson

Biochim Biophys Acta 2006 Jul 19;1762(7):647-55. Epub 2006 May 19.

Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.

View Article and Find Full Text PDF
July 2006

Tissue-specific reduction in splicing efficiency of IKBKAP due to the major mutation associated with familial dysautonomia.

Authors:
Math P Cuajungco Maire Leyne James Mull Sandra P Gill Weining Lu David Zagzag Felicia B Axelrod Channa Maayan James F Gusella Susan A Slaugenhaupt

Am J Hum Genet 2003 Mar 6;72(3):749-58. Epub 2003 Feb 6.

Harvard Institute of Human Genetics, Harvard Medical School, Boston, MA, USA.

View Article and Find Full Text PDF
March 2003

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells.

Authors:
Surya M Nauli Francis J Alenghat Ying Luo Eric Williams Peter Vassilev Xiaogang Li Andrew E H Elia Weining Lu Edward M Brown Stephen J Quinn Donald E Ingber Jing Zhou

Nat Genet 2003 Feb 6;33(2):129-37. Epub 2003 Jan 6.

Renal Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 4 Blackfan Circle, Boston, Massachusetts 02115, USA.

View Article and Find Full Text PDF
February 2003

A defect in a novel Nek-family kinase causes cystic kidney disease in the mouse and in zebrafish.

Authors:
Shanming Liu Weining Lu Tomoko Obara Shiei Kuida Jennifer Lehoczky Ken Dewar Iain A Drummond David R Beier

Development 2002 Dec;129(24):5839-46

Genetics Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

View Article and Find Full Text PDF
December 2002