Weijia Xie

Weijia Xie

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Weijia Xie

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Recent Progress in Construction of Natural De-O-sulfonated Sulfonium Sugars with Antidiabetic Activities.

Chemistry 2019 Jul 17. Epub 2019 Jul 17.

China Pharmaceutical University, Medicinal Chemistry, Tongjiaxiang 24#, 210009, Nanjing, CHINA.

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http://dx.doi.org/10.1002/chem.201902562DOI Listing
July 2019

Practical Route to Neokotalanol and Its Natural Analogues: Sulfonium Sugars with Antidiabetic Activities.

Angew Chem Int Ed Engl 2019 May 18;58(19):6400-6404. Epub 2019 Mar 18.

State Key Laboratory of Natural Medicines (SKLNM) and Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, P. R. China.

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http://dx.doi.org/10.1002/anie.201900761DOI Listing
May 2019

Melatonin attenuates expression of cyclooxygenase-2 (COX-2) in activated microglia induced by lipopolysaccharide (LPS).

J Toxicol Environ Health A 2019 12;82(7):437-446. Epub 2019 May 12.

a Department of Epidemiology , College of Preventive Medicine, Army Medical University (Third Military Medical University) , Chongqing , China.

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http://dx.doi.org/10.1080/15287394.2019.1615019DOI Listing
May 2019

Hypoxia-sensitive LINC01436 is regulated by E2F6 and acts as an oncogene by targeting miR-30a-3p in non-small cell lung cancer.

Mol Oncol 2019 04 30;13(4):840-856. Epub 2019 Jan 30.

Department of Epidemiology, College of Preventive Medicine, Army Medical University (Third Military Medical University), Chongqing, China.

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http://dx.doi.org/10.1002/1878-0261.12437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441908PMC
April 2019

Influenza A(H7N9) virus emerged and resulted in human infections in Chongqing, southwestern China since 2017.

Int J Infect Dis 2019 Apr 21;81:244-250. Epub 2019 Feb 21.

Department of Epidemiology, College of Preventive Medicine, Army Medical University (Third Military Medical University), Chongqing 400038, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.ijid.2019.02.011DOI Listing
April 2019

Differential methylation of the type 2 diabetes susceptibility locus KCNQ1 is associated with insulin sensitivity and is predicted by CpG site specific genetic variation.

Diabetes Res Clin Pract 2019 Feb 11;148:189-199. Epub 2019 Jan 11.

Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne NE1 7RU, UK; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol BS8 2BN, UK; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol BS8 2BN, UK. Electronic address:

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http://dx.doi.org/10.1016/j.diabres.2019.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395844PMC
February 2019

Design, Synthesis and Biological Evaluation of Nitrate Derivatives of Sauropunol A and B as Potent Vasodilatory Agents.

Molecules 2019 Feb 6;24(3). Epub 2019 Feb 6.

State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, China.

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http://dx.doi.org/10.3390/molecules24030583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384914PMC
February 2019

Recent Advances for the Synthesis of Selenium-containing Small Molecules as Potent Antitumor Agents.

Curr Med Chem 2018 ;25(17):2009-2033

State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, China.

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http://www.eurekaselect.com/157879/article
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http://dx.doi.org/10.2174/0929867325666171129220544DOI Listing
November 2018

Plasma exosome levels in non-small-cell lung cancer: Correlation with clinicopathological features and prognostic implications.

Cancer Biomark 2018 ;22(2):267-274

Department of Epidemiology, College of Preventive Medicine, Army Medical University (Third Military Medical University), Chongqing 400038, China.

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http://dx.doi.org/10.3233/CBM-170955DOI Listing
October 2018

Impact of dipeptidyl-peptidase 4 inhibitors on cardiovascular diseases.

Vascul Pharmacol 2018 10 4;109:17-26. Epub 2018 Jun 4.

Department of Vascular Surgery, The Second Affiliated Hospital, College of Medicine, Zhejiang University, 88 Jiefang Street, Hangzhou 310009, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.vph.2018.05.010DOI Listing
October 2018

Predicting obstructive coronary artery disease using carotid ultrasound parameters: A nomogram from a large real-world clinical data.

Eur J Clin Invest 2018 Aug 10;48(8):e12956. Epub 2018 Jul 10.

Cardiovascular Disease Center, Third Affiliated Hospital of Chongqing Medical University, Chongqing, China.

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http://dx.doi.org/10.1111/eci.12956DOI Listing
August 2018

Abdominal cocoon with early postoperative small bowel obstruction: A case report and review of literature in China.

Medicine (Baltimore) 2018 Jun;97(25):e11102

Second Affiliated Hospital of Zhejiang University school of medicine, Hangzhou, China.

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http://dx.doi.org/10.1097/MD.0000000000011102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023681PMC
June 2018

Long non-coding RNA MUC5B-AS1 promotes metastasis through mutually regulating MUC5B expression in lung adenocarcinoma.

Cell Death Dis 2018 05 1;9(5):450. Epub 2018 May 1.

Department of Epidemiology, College of Preventive Medicine, Army Medical University (Third Military Medical University), 400038, Chongqing, China.

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http://dx.doi.org/10.1038/s41419-018-0472-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906460PMC
May 2018

Association of Systemic Inflammation Score With Atrial Fibrillation: A Case-Control Study With Propensity Score Matching.

Heart Lung Circ 2018 Apr 10;27(4):489-496. Epub 2017 May 10.

Department of Epidemiology, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, People's Republic of China; Evidence-based Medicine and Clinical Epidemiology Center, Third Military Medical University, Chongqing 400038, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.hlc.2017.04.007DOI Listing
April 2018

Efficient and ultraviolet durable planar perovskite solar cells via a ferrocenecarboxylic acid modified nickel oxide hole transport layer.

Nanoscale 2018 Mar 12;10(12):5617-5625. Epub 2018 Mar 12.

Engineering Research Center for Nanophotonics and Advanced Instrument, Ministry of Education, and School of Physics and Materials Science, East China Normal University, Shanghai 200062, China.

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http://xlink.rsc.org/?DOI=C7NR08750K
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http://dx.doi.org/10.1039/c7nr08750kDOI Listing
March 2018

Diastereoselective Synthesis of Salacinol-Type α-Glucosidase Inhibitors.

J Org Chem 2018 01 14;83(1):185-193. Epub 2017 Dec 14.

State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University , Nanjing 210009, P. R. China.

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http://dx.doi.org/10.1021/acs.joc.7b02566DOI Listing
January 2018

Protein C deficiency resulting from two mutations in presenting with recurrent venous thromboembolism.

J Vasc Surg Cases Innov Tech 2017 Dec 18;3(4):254-256. Epub 2017 Dec 18.

Department of Vascular Surgery, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

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http://dx.doi.org/10.1016/j.jvscit.2017.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765183PMC
December 2017

Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.

Authors:
M Carola Zillikens Serkalem Demissie Yi-Hsiang Hsu Laura M Yerges-Armstrong Wen-Chi Chou Lisette Stolk Gregory Livshits Linda Broer Toby Johnson Daniel L Koller Zoltán Kutalik Jian'an Luan Ida Malkin Janina S Ried Albert V Smith Gudmar Thorleifsson Liesbeth Vandenput Jing Hua Zhao Weihua Zhang Ali Aghdassi Kristina Åkesson Najaf Amin Leslie J Baier Inês Barroso David A Bennett Lars Bertram Rainer Biffar Murielle Bochud Michael Boehnke Ingrid B Borecki Aron S Buchman Liisa Byberg Harry Campbell Natalia Campos Obanda Jane A Cauley Peggy M Cawthon Henna Cederberg Zhao Chen Nam H Cho Hyung Jin Choi Melina Claussnitzer Francis Collins Steven R Cummings Philip L De Jager Ilja Demuth Rosalie A M Dhonukshe-Rutten Luda Diatchenko Gudny Eiriksdottir Anke W Enneman Mike Erdos Johan G Eriksson Joel Eriksson Karol Estrada Daniel S Evans Mary F Feitosa Mao Fu Melissa Garcia Christian Gieger Thomas Girke Nicole L Glazer Harald Grallert Jagvir Grewal Bok-Ghee Han Robert L Hanson Caroline Hayward Albert Hofman Eric P Hoffman Georg Homuth Wen-Chi Hsueh Monica J Hubal Alan Hubbard Kim M Huffman Lise B Husted Thomas Illig Erik Ingelsson Till Ittermann John-Olov Jansson Joanne M Jordan Antti Jula Magnus Karlsson Kay-Tee Khaw Tuomas O Kilpeläinen Norman Klopp Jacqueline S L Kloth Heikki A Koistinen William E Kraus Stephen Kritchevsky Teemu Kuulasmaa Johanna Kuusisto Markku Laakso Jari Lahti Thomas Lang Bente L Langdahl Lenore J Launer Jong-Young Lee Markus M Lerch Joshua R Lewis Lars Lind Cecilia Lindgren Yongmei Liu Tian Liu Youfang Liu Östen Ljunggren Mattias Lorentzon Robert N Luben William Maixner Fiona E McGuigan Carolina Medina-Gomez Thomas Meitinger Håkan Melhus Dan Mellström Simon Melov Karl Michaëlsson Braxton D Mitchell Andrew P Morris Leif Mosekilde Anne Newman Carrie M Nielson Jeffrey R O'Connell Ben A Oostra Eric S Orwoll Aarno Palotie Stephen C J Parker Munro Peacock Markus Perola Annette Peters Ozren Polasek Richard L Prince Katri Räikkönen Stuart H Ralston Samuli Ripatti John A Robbins Jerome I Rotter Igor Rudan Veikko Salomaa Suzanne Satterfield Eric E Schadt Sabine Schipf Laura Scott Joban Sehmi Jian Shen Chan Soo Shin Gunnar Sigurdsson Shad Smith Nicole Soranzo Alena Stančáková Elisabeth Steinhagen-Thiessen Elizabeth A Streeten Unnur Styrkarsdottir Karin M A Swart Sian-Tsung Tan Mark A Tarnopolsky Patricia Thompson Cynthia A Thomson Unnur Thorsteinsdottir Emmi Tikkanen Gregory J Tranah Jaakko Tuomilehto Natasja M van Schoor Arjun Verma Peter Vollenweider Henry Völzke Jean Wactawski-Wende Mark Walker Michael N Weedon Ryan Welch H-Erich Wichmann Elisabeth Widen Frances M K Williams James F Wilson Nicole C Wright Weijia Xie Lei Yu Yanhua Zhou John C Chambers Angela Döring Cornelia M van Duijn Michael J Econs Vilmundur Gudnason Jaspal S Kooner Bruce M Psaty Timothy D Spector Kari Stefansson Fernando Rivadeneira André G Uitterlinden Nicholas J Wareham Vicky Ossowski Dawn Waterworth Ruth J F Loos David Karasik Tamara B Harris Claes Ohlsson Douglas P Kiel

Nat Commun 2017 11 7;8(1):1414. Epub 2017 Nov 7.

Hebrew SeniorLife, Institute for Aging Research, Roslindale, MA, 02131, USA.

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http://dx.doi.org/10.1038/s41467-017-01008-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676783PMC
November 2017

The draft genome assembly of Rhododendron delavayi Franch. var. delavayi.

Gigascience 2017 10;6(10):1-11

Flower Research Institute of Yunnan Academy of Agricultural Sciences, National Engineering Research Center For Ornamental Horticulture, No. 2238 Beijing Road, Panlong District, Kunming 650205, China.

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http://dx.doi.org/10.1093/gigascience/gix076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632301PMC
October 2017

6,7-Seco-ent-Kauranoids Derived from Oridonin as Potential Anticancer Agents.

J Nat Prod 2017 09 13;80(9):2391-2398. Epub 2017 Sep 13.

State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University , Nanjing 210009, People's Republic of China.

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http://dx.doi.org/10.1021/acs.jnatprod.7b00057DOI Listing
September 2017

Epidemiology of tuberculosis in Chongqing, China: a secular trend from 1992 to 2015.

Sci Rep 2017 08 10;7(1):7832. Epub 2017 Aug 10.

Department of Epidemiology, College of Preventive Medicine, Third Military Medical University, Chongqing, 400038, People's Republic of China.

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http://dx.doi.org/10.1038/s41598-017-07959-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552739PMC
August 2017

Genetic predisposition to lung cancer: comprehensive literature integration, meta-analysis, and multiple evidence assessment of candidate-gene association studies.

Sci Rep 2017 08 21;7(1):8371. Epub 2017 Aug 21.

Department of Epidemiology, College of Preventive Medicine, Third Military Medical University, Chongqing, People's Republic of China.

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http://dx.doi.org/10.1038/s41598-017-07737-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567126PMC
August 2017

Discovery of novel antitumor nitric oxide-donating β-elemene hybrids through inhibiting the PI3K/Akt pathway.

Eur J Med Chem 2017 Jul 20;135:414-423. Epub 2017 Apr 20.

State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S02235234173031
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http://dx.doi.org/10.1016/j.ejmech.2017.04.045DOI Listing
July 2017

Novel hybrids of natural β-elemene bearing isopropanolamine moieties: Synthesis, enhanced anticancer profile, and improved aqueous solubility.

Fitoterapia 2017 Jul 31;120:117-125. Epub 2017 May 31.

State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.fitote.2017.05.002DOI Listing
July 2017

Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.

Authors:
M Carola Zillikens Serkalem Demissie Yi-Hsiang Hsu Laura M Yerges-Armstrong Wen-Chi Chou Lisette Stolk Gregory Livshits Linda Broer Toby Johnson Daniel L Koller Zoltán Kutalik Jian'an Luan Ida Malkin Janina S Ried Albert V Smith Gudmar Thorleifsson Liesbeth Vandenput Jing Hua Zhao Weihua Zhang Ali Aghdassi Kristina Åkesson Najaf Amin Leslie J Baier Inês Barroso David A Bennett Lars Bertram Rainer Biffar Murielle Bochud Michael Boehnke Ingrid B Borecki Aron S Buchman Liisa Byberg Harry Campbell Natalia Campos Obanda Jane A Cauley Peggy M Cawthon Henna Cederberg Zhao Chen Nam H Cho Hyung Jin Choi Melina Claussnitzer Francis Collins Steven R Cummings Philip L De Jager Ilja Demuth Rosalie A M Dhonukshe-Rutten Luda Diatchenko Gudny Eiriksdottir Anke W Enneman Mike Erdos Johan G Eriksson Joel Eriksson Karol Estrada Daniel S Evans Mary F Feitosa Mao Fu Melissa Garcia Christian Gieger Thomas Girke Nicole L Glazer Harald Grallert Jagvir Grewal Bok-Ghee Han Robert L Hanson Caroline Hayward Albert Hofman Eric P Hoffman Georg Homuth Wen-Chi Hsueh Monica J Hubal Alan Hubbard Kim M Huffman Lise B Husted Thomas Illig Erik Ingelsson Till Ittermann John-Olov Jansson Joanne M Jordan Antti Jula Magnus Karlsson Kay-Tee Khaw Tuomas O Kilpeläinen Norman Klopp Jacqueline S L Kloth Heikki A Koistinen William E Kraus Stephen Kritchevsky Teemu Kuulasmaa Johanna Kuusisto Markku Laakso Jari Lahti Thomas Lang Bente L Langdahl Lenore J Launer Jong-Young Lee Markus M Lerch Joshua R Lewis Lars Lind Cecilia Lindgren Yongmei Liu Tian Liu Youfang Liu Östen Ljunggren Mattias Lorentzon Robert N Luben William Maixner Fiona E McGuigan Carolina Medina-Gomez Thomas Meitinger Håkan Melhus Dan Mellström Simon Melov Karl Michaëlsson Braxton D Mitchell Andrew P Morris Leif Mosekilde Anne Newman Carrie M Nielson Jeffrey R O'Connell Ben A Oostra Eric S Orwoll Aarno Palotie Stephen C J Parker Munro Peacock Markus Perola Annette Peters Ozren Polasek Richard L Prince Katri Räikkönen Stuart H Ralston Samuli Ripatti John A Robbins Jerome I Rotter Igor Rudan Veikko Salomaa Suzanne Satterfield Eric E Schadt Sabine Schipf Laura Scott Joban Sehmi Jian Shen Chan Soo Shin Gunnar Sigurdsson Shad Smith Nicole Soranzo Alena Stančáková Elisabeth Steinhagen-Thiessen Elizabeth A Streeten Unnur Styrkarsdottir Karin M A Swart Sian-Tsung Tan Mark A Tarnopolsky Patricia Thompson Cynthia A Thomson Unnur Thorsteinsdottir Emmi Tikkanen Gregory J Tranah Jaakko Tuomilehto Natasja M van Schoor Arjun Verma Peter Vollenweider Henry Völzke Jean Wactawski-Wende Mark Walker Michael N Weedon Ryan Welch H-Erich Wichmann Elisabeth Widen Frances M K Williams James F Wilson Nicole C Wright Weijia Xie Lei Yu Yanhua Zhou John C Chambers Angela Döring Cornelia M van Duijn Michael J Econs Vilmundur Gudnason Jaspal S Kooner Bruce M Psaty Timothy D Spector Kari Stefansson Fernando Rivadeneira André G Uitterlinden Nicholas J Wareham Vicky Ossowski Dawn Waterworth Ruth J F Loos David Karasik Tamara B Harris Claes Ohlsson Douglas P Kiel

Nat Commun 2017 07 19;8(1):80. Epub 2017 Jul 19.

Hebrew SeniorLife, Institute for Aging Research, Roslindale, MA, 02131, USA.

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http://dx.doi.org/10.1038/s41467-017-00031-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517526PMC
July 2017

Design, synthesis and biological evaluation of novel nitric oxide-donating protoberberine derivatives as antitumor agents.

Eur J Med Chem 2017 May 18;132:173-183. Epub 2017 Mar 18.

State Key Laboratory of Natural Medicines, Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2017.03.027DOI Listing
May 2017

Antioxidant Properties of Novel Dimers Derived from Natural β-Elemene through Inhibiting HO-Induced Apoptosis.

ACS Med Chem Lett 2017 Apr 13;8(4):443-448. Epub 2017 Mar 13.

State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, P. R. China.

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http://pubs.acs.org/doi/10.1021/acsmedchemlett.7b00035
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http://dx.doi.org/10.1021/acsmedchemlett.7b00035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392764PMC
April 2017

Circulating exosomal microRNAs as prognostic biomarkers for non-small-cell lung cancer.

Oncotarget 2017 Feb;8(8):13048-13058

Department of Epidemiology, College of Preventive Medicine, Third Military Medical University, Chongqing, People's Republic of China.

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http://dx.doi.org/10.18632/oncotarget.14369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355076PMC
February 2017

A Novel Potent Anticancer Compound Optimized from a Natural Oridonin Scaffold Induces Apoptosis and Cell Cycle Arrest through the Mitochondrial Pathway.

J Med Chem 2017 02 13;60(4):1449-1468. Epub 2017 Feb 13.

State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University , 24 Tong Jia Xiang, Nanjing 210009, P. R. China.

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http://dx.doi.org/10.1021/acs.jmedchem.6b01652DOI Listing
February 2017

Total synthesis, structural elucidation and anti-inflammatory activity evaluation of 2-deoxy-3,6-anhydro hexofuranoside derivatives isolated from Sauropus rostratus.

Org Biomol Chem 2016 Nov;14(46):10906-10913

State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, P. R. China.

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http://dx.doi.org/10.1039/c6ob02207cDOI Listing
November 2016

Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci.

Diabetes 2016 10 14;65(10):3200-11. Epub 2016 Jul 14.

Diabetes Research Center (Diabetes Unit), Massachusetts General Hospital, Boston, MA Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA Department of Medicine, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.2337/db16-0199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033262PMC
October 2016

Long noncoding and circular RNAs in lung cancer: advances and perspectives.

Epigenomics 2016 09 2;8(9):1275-87. Epub 2016 Sep 2.

Department of Epidemiology, College of Preventive Medicine, Third Military Medical University, Chongqing, People's Republic of China.

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http://dx.doi.org/10.2217/epi-2016-0036DOI Listing
September 2016

Hydrophobic substituents increase the potency of salacinol, a potent α-glucosidase inhibitor from Ayurvedic traditional medicine 'Salacia'.

Bioorg Med Chem 2016 08 7;24(16):3705-15. Epub 2016 Jun 7.

Faculty of Pharmacy, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan; Pharmaceutical Research and Technology Institute, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2016.06.013DOI Listing
August 2016

Probing the Anticancer Action of Oridonin with Fluorescent Analogues: Visualizing Subcellular Localization to Mitochondria.

J Med Chem 2016 05 27;59(10):5022-34. Epub 2016 Apr 27.

State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University , 24 Tong Jia Xiang, Nanjing 210009, P. R. China.

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http://dx.doi.org/10.1021/acs.jmedchem.6b00408DOI Listing
May 2016

Design, synthesis and biological evaluation of 3'-benzylated analogs of 3'-epi-neoponkoranol as potent α-glucosidase inhibitors.

Eur J Med Chem 2016 Mar 22;110:224-36. Epub 2016 Jan 22.

State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China; Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2016.01.029DOI Listing
March 2016

Using Genetic Variants to Assess the Relationship Between Circulating Lipids and Type 2 Diabetes.

Diabetes 2015 Jul 6;64(7):2676-84. Epub 2015 May 6.

Molecular Epidemiology, Department of Medical Sciences and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.2337/db14-1710DOI Listing
July 2015

An exome sequencing strategy to diagnose lethal autosomal recessive disorders.

Eur J Hum Genet 2015 Mar 25;23(3):401-4. Epub 2014 Jun 25.

Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK.

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http://www.nature.com/articles/ejhg2014120
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http://dx.doi.org/10.1038/ejhg.2014.120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4205099PMC
March 2015

Regioselective ortho olefination of aryl sulfonamide via rhodium-catalyzed direct C-H bond activation.

J Org Chem 2014 Sep 11;79(17):8278-87. Epub 2014 Aug 11.

State Key Laboratory of Element-Organic Chemistry, Synergetic Innovation Center of Chemical Science and Engineering, College of Chemistry, Nankai University , Tianjin 300071, People's Republic of China.

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http://pubs.acs.org/doi/10.1021/jo5015239
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http://dx.doi.org/10.1021/jo5015239DOI Listing
September 2014

Unidirectional hybridization and reproductive barriers between two heterostylous primrose species in north-west Yunnan, China.

Ann Bot 2014 Apr 2;113(5):763-75. Epub 2014 Feb 2.

Kunming Botanical Garden, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.

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http://dx.doi.org/10.1093/aob/mct312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962241PMC
April 2014

Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes.

Diabetes 2013 Oct 8;62(10):3589-98. Epub 2013 Jul 8.

Genetics of Complex Traits, University of Exeter Medical School, Exeter, U.K.

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http://dx.doi.org/10.2337/db13-0128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781444PMC
October 2013

Regioselective C2 Oxidative Olefination of Indoles and Pyrroles through Cationic Rhodium(III)-Catalyzed C-H Bond Activation.

Chemistry 2013 Sep 23;19(36):11863-8. Epub 2013 Jul 23.

State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071 (China), Fax: (+86) 22-2350-4781.

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http://dx.doi.org/10.1002/chem.201301987DOI Listing
September 2013

Ruthenium-catalyzed regioselective C2 alkenylation of indoles and pyrroles via C-H bond functionalization.

J Org Chem 2013 Sep 11;78(18):9345-53. Epub 2013 Sep 11.

State Key Laboratory of Element-Organic Chemistry, Synergetic Innovation Center of Chemical Science and Engineering, College of Chemistry, Nankai University , Tianjin 300071, P. R. China.

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http://dx.doi.org/10.1021/jo401579mDOI Listing
September 2013

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.

Authors:
Marcel den Hoed Mark Eijgelsheim Tõnu Esko Bianca J J M Brundel David S Peal David M Evans Ilja M Nolte Ayellet V Segrè Hilma Holm Robert E Handsaker Harm-Jan Westra Toby Johnson Aaron Isaacs Jian Yang Alicia Lundby Jing Hua Zhao Young Jin Kim Min Jin Go Peter Almgren Murielle Bochud Gabrielle Boucher Marilyn C Cornelis Daniel Gudbjartsson David Hadley Pim van der Harst Caroline Hayward Martin den Heijer Wilmar Igl Anne U Jackson Zoltán Kutalik Jian'an Luan John P Kemp Kati Kristiansson Claes Ladenvall Mattias Lorentzon May E Montasser Omer T Njajou Paul F O'Reilly Sandosh Padmanabhan Beate St Pourcain Tuomo Rankinen Perttu Salo Toshiko Tanaka Nicholas J Timpson Veronique Vitart Lindsay Waite William Wheeler Weihua Zhang Harmen H M Draisma Mary F Feitosa Kathleen F Kerr Penelope A Lind Evelin Mihailov N Charlotte Onland-Moret Ci Song Michael N Weedon Weijia Xie Loic Yengo Devin Absher Christine M Albert Alvaro Alonso Dan E Arking Paul I W de Bakker Beverley Balkau Cristina Barlassina Paola Benaglio Joshua C Bis Nabila Bouatia-Naji Søren Brage Stephen J Chanock Peter S Chines Mina Chung Dawood Darbar Christian Dina Marcus Dörr Paul Elliott Stephan B Felix Krista Fischer Christian Fuchsberger Eco J C de Geus Philippe Goyette Vilmundur Gudnason Tamara B Harris Anna-Liisa Hartikainen Aki S Havulinna Susan R Heckbert Andrew A Hicks Albert Hofman Suzanne Holewijn Femke Hoogstra-Berends Jouke-Jan Hottenga Majken K Jensen Asa Johansson Juhani Junttila Stefan Kääb Bart Kanon Shamika Ketkar Kay-Tee Khaw Joshua W Knowles Angrad S Kooner Jan A Kors Meena Kumari Lili Milani Päivi Laiho Edward G Lakatta Claudia Langenberg Maarten Leusink Yongmei Liu Robert N Luben Kathryn L Lunetta Stacey N Lynch Marcello R P Markus Pedro Marques-Vidal Irene Mateo Leach Wendy L McArdle Steven A McCarroll Sarah E Medland Kathryn A Miller Grant W Montgomery Alanna C Morrison Martina Müller-Nurasyid Pau Navarro Mari Nelis Jeffrey R O'Connell Christopher J O'Donnell Ken K Ong Anne B Newman Annette Peters Ozren Polasek Anneli Pouta Peter P Pramstaller Bruce M Psaty Dabeeru C Rao Susan M Ring Elizabeth J Rossin Diana Rudan Serena Sanna Robert A Scott Jaban S Sehmi Stephen Sharp Jordan T Shin Andrew B Singleton Albert V Smith Nicole Soranzo Tim D Spector Chip Stewart Heather M Stringham Kirill V Tarasov André G Uitterlinden Liesbeth Vandenput Shih-Jen Hwang John B Whitfield Cisca Wijmenga Sarah H Wild Gonneke Willemsen James F Wilson Jacqueline C M Witteman Andrew Wong Quenna Wong Yalda Jamshidi Paavo Zitting Jolanda M A Boer Dorret I Boomsma Ingrid B Borecki Cornelia M van Duijn Ulf Ekelund Nita G Forouhi Philippe Froguel Aroon Hingorani Erik Ingelsson Mika Kivimaki Richard A Kronmal Diana Kuh Lars Lind Nicholas G Martin Ben A Oostra Nancy L Pedersen Thomas Quertermous Jerome I Rotter Yvonne T van der Schouw W M Monique Verschuren Mark Walker Demetrius Albanes David O Arnar Themistocles L Assimes Stefania Bandinelli Michael Boehnke Rudolf A de Boer Claude Bouchard W L Mark Caulfield John C Chambers Gary Curhan Daniele Cusi Johan Eriksson Luigi Ferrucci Wiek H van Gilst Nicola Glorioso Jacqueline de Graaf Leif Groop Ulf Gyllensten Wen-Chi Hsueh Frank B Hu Heikki V Huikuri David J Hunter Carlos Iribarren Bo Isomaa Marjo-Riitta Jarvelin Antti Jula Mika Kähönen Lambertus A Kiemeney Melanie M van der Klauw Jaspal S Kooner Peter Kraft Licia Iacoviello Terho Lehtimäki Marja-Liisa L Lokki Braxton D Mitchell Gerjan Navis Markku S Nieminen Claes Ohlsson Neil R Poulter Lu Qi Olli T Raitakari Eric B Rimm John D Rioux Federica Rizzi Igor Rudan Veikko Salomaa Peter S Sever Denis C Shields Alan R Shuldiner Juha Sinisalo Alice V Stanton Ronald P Stolk David P Strachan Jean-Claude Tardif Unnur Thorsteinsdottir Jaako Tuomilehto Dirk J van Veldhuisen Jarmo Virtamo Jorma Viikari Peter Vollenweider Gérard Waeber Elisabeth Widen Yoon Shin Cho Jesper V Olsen Peter M Visscher Cristen Willer Lude Franke Jeanette Erdmann John R Thompson Arne Pfeufer Nona Sotoodehnia Christopher Newton-Cheh Patrick T Ellinor Bruno H Ch Stricker Andres Metspalu Markus Perola Jacques S Beckmann George Davey Smith Kari Stefansson Nicholas J Wareham Patricia B Munroe Ody C M Sibon David J Milan Harold Snieder Nilesh J Samani Ruth J F Loos

Nat Genet 2013 Jun 14;45(6):621-31. Epub 2013 Apr 14.

Medical Research Council MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696959PMC
June 2013

Novel nitric oxide-releasing isochroman-4-one derivatives: Synthesis and evaluation of antihypertensive activity.

Bioorg Med Chem 2012 Dec 28;20(23):6848-55. Epub 2012 Sep 28.

Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, PR China.

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http://dx.doi.org/10.1016/j.bmc.2012.09.043DOI Listing
December 2012

Synthesis and biological evaluation of 4'-[(benzimidazole-1-yl)methyl]biphenyl-2-sulfonamide derivatives as dual angiotensin II/endothelin A receptor antagonists.

Bioorg Med Chem 2012 Aug 15;20(15):4661-7. Epub 2012 Jun 15.

Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China.

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August 2012

No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels.

Authors:
Robert A Scott Audrey Y Chu Niels Grarup Alisa K Manning Marie-France Hivert Dmitry Shungin Anke Tönjes Ajay Yesupriya Daniel Barnes Nabila Bouatia-Naji Nicole L Glazer Anne U Jackson Zoltán Kutalik Vasiliki Lagou Diana Marek Laura J Rasmussen-Torvik Heather M Stringham Toshiko Tanaka Mette Aadahl Dan E Arking Sven Bergmann Eric Boerwinkle Lori L Bonnycastle Stefan R Bornstein Eric Brunner Suzannah J Bumpstead Soren Brage Olga D Carlson Han Chen Yii-Der Ida Chen Peter S Chines Francis S Collins David J Couper Elaine M Dennison Nicole F Dowling Josephine S Egan Ulf Ekelund Michael R Erdos Nita G Forouhi Caroline S Fox Mark O Goodarzi Jürgen Grässler Stefan Gustafsson Göran Hallmans Torben Hansen Aroon Hingorani John W Holloway Frank B Hu Bo Isomaa Karen A Jameson Ingegerd Johansson Anna Jonsson Torben Jørgensen Mika Kivimaki Peter Kovacs Meena Kumari Johanna Kuusisto Markku Laakso Cécile Lecoeur Claire Lévy-Marchal Guo Li Ruth J F Loos Valeri Lyssenko Michael Marmot Pedro Marques-Vidal Mario A Morken Gabriele Müller Kari E North James S Pankow Felicity Payne Inga Prokopenko Bruce M Psaty Frida Renström Ken Rice Jerome I Rotter Denis Rybin Camilla H Sandholt Avan A Sayer Peter Shrader Peter E H Schwarz David S Siscovick Alena Stancáková Michael Stumvoll Tanya M Teslovich Gérard Waeber Gordon H Williams Daniel R Witte Andrew R Wood Weijia Xie Michael Boehnke Cyrus Cooper Luigi Ferrucci Philippe Froguel Leif Groop W H Linda Kao Peter Vollenweider Mark Walker Richard M Watanabe Oluf Pedersen James B Meigs Erik Ingelsson Inês Barroso Jose C Florez Paul W Franks Josée Dupuis Nicholas J Wareham Claudia Langenberg

Diabetes 2012 May 13;61(5):1291-6. Epub 2012 Mar 13.

Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331745PMC
May 2012

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.

Authors:
Rona J Strawbridge Josée Dupuis Inga Prokopenko Adam Barker Emma Ahlqvist Denis Rybin John R Petrie Mary E Travers Nabila Bouatia-Naji Antigone S Dimas Alexandra Nica Eleanor Wheeler Han Chen Benjamin F Voight Jalal Taneera Stavroula Kanoni John F Peden Fabiola Turrini Stefan Gustafsson Carina Zabena Peter Almgren David J P Barker Daniel Barnes Elaine M Dennison Johan G Eriksson Per Eriksson Elodie Eury Lasse Folkersen Caroline S Fox Timothy M Frayling Anuj Goel Harvest F Gu Momoko Horikoshi Bo Isomaa Anne U Jackson Karen A Jameson Eero Kajantie Julie Kerr-Conte Teemu Kuulasmaa Johanna Kuusisto Ruth J F Loos Jian'an Luan Konstantinos Makrilakis Alisa K Manning María Teresa Martínez-Larrad Narisu Narisu Maria Nastase Mannila John Ohrvik Clive Osmond Laura Pascoe Felicity Payne Avan A Sayer Bengt Sennblad Angela Silveira Alena Stancáková Kathy Stirrups Amy J Swift Ann-Christine Syvänen Tiinamaija Tuomi Ferdinand M van 't Hooft Mark Walker Michael N Weedon Weijia Xie Björn Zethelius Halit Ongen Anders Mälarstig Jemma C Hopewell Danish Saleheen John Chambers Sarah Parish John Danesh Jaspal Kooner Claes-Göran Ostenson Lars Lind Cyrus C Cooper Manuel Serrano-Ríos Ele Ferrannini Tom J Forsen Robert Clarke Maria Grazia Franzosi Udo Seedorf Hugh Watkins Philippe Froguel Paul Johnson Panos Deloukas Francis S Collins Markku Laakso Emmanouil T Dermitzakis Michael Boehnke Mark I McCarthy Nicholas J Wareham Leif Groop François Pattou Anna L Gloyn George V Dedoussis Valeriya Lyssenko James B Meigs Inês Barroso Richard M Watanabe Erik Ingelsson Claudia Langenberg Anders Hamsten Jose C Florez

Diabetes 2011 Oct 26;60(10):2624-34. Epub 2011 Aug 26.

Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden.

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http://dx.doi.org/10.2337/db11-0415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178302PMC
October 2011

Role of the side chain stereochemistry in the α-glucosidase inhibitory activity of kotalanol, a potent natural α-glucosidase inhibitor.

Bioorg Med Chem 2011 Apr 24;19(7):2252-62. Epub 2011 Feb 24.

School of Pharmacy, Kinki University, 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan.

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April 2011

Isolation, structure identification and SAR studies on thiosugar sulfonium salts, neosalaprinol and neoponkoranol, as potent α-glucosidase inhibitors.

Bioorg Med Chem 2011 Mar 31;19(6):2015-22. Epub 2011 Jan 31.

School of Pharmacy, Kinki University, 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan.

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http://dx.doi.org/10.1016/j.bmc.2011.01.052DOI Listing
March 2011

Facile synthesis of de-O-sulfated salacinols: revision of the structure of neosalacinol, a potent alpha-glucosidase inhibitor.

Bioorg Med Chem Lett 2009 Apr 1;19(8):2195-8. Epub 2009 Mar 1.

School of Pharmacy, Kinki University, Higashi-osaka, Osaka, Japan.

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April 2009