Publications by authors named "Weihong Tan"

100Publications

A materials-science perspective on tackling COVID-19.

Nat Rev Mater 2020 Oct 14:1-14. Epub 2020 Oct 14.

Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA USA.

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http://dx.doi.org/10.1038/s41578-020-00247-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556605PMC
October 2020

Enhancing nucleolytic resistance and bioactivity of functional nucleic acids by diverse nanostructures via in situ polymerization-induced self-assembly.

Chembiochem 2020 Oct 14. Epub 2020 Oct 14.

Hunan University, College of Chemistry and Chemical Engineering, Department of Chemistry, 208 Yifu building, 410082, Changsha, CHINA.

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http://dx.doi.org/10.1002/cbic.202000712DOI Listing
October 2020

3D printed intelligent scaffold prevents recurrence and distal metastasis of breast cancer.

Theranostics 2020 29;10(23):10652-10664. Epub 2020 Aug 29.

College of Biology, Hunan University, Changsha, Hunan, 410082, China.

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http://dx.doi.org/10.7150/thno.47933DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482818PMC
August 2020

A General Strategy for Development of Activatable NIR-II Fluorescent Probes for in vivo High-Contrast Bioimaging.

Angew Chem Int Ed Engl 2020 Sep 11. Epub 2020 Sep 11.

Hunan University, College of Chemistry and Chemical Engineering, CHINA.

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http://dx.doi.org/10.1002/anie.202009986DOI Listing
September 2020

Molecular Transport through a Biomimetic DNA Channel on Live Cell Membranes.

ACS Nano 2020 Sep 14. Epub 2020 Sep 14.

Institute of Molecular Medicine (IMM), Department of Anesthesiology, Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Renji Hospital, State Key Laboratory of Oncogenes and Related Genes, School of Medicine and College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200127, China.

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http://dx.doi.org/10.1021/acsnano.0c03105DOI Listing
September 2020

Highly Sensitive MicroRNA Detection by Coupling Nicking-Enhanced Rolling Circle Amplification with MoS Quantum Dots.

Anal Chem 2020 Oct 17;92(19):13588-13594. Epub 2020 Sep 17.

Molecular Science and Biomedicine Laboratory, State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, College of Material Science and Engineering, and Collaborative Research Center of Molecular Engineering for Theranostics, Hunan University, Changsha 410082, China.

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http://dx.doi.org/10.1021/acs.analchem.0c03405DOI Listing
October 2020

Polyaniline Nanovesicles for Photoacoustic Imaging-Guided Photothermal-Chemo Synergistic Therapy in the Second Near-Infrared Window.

Small 2020 Sep 6;16(35):e2001177. Epub 2020 Aug 6.

Institute of Molecular Medicine (IMM), Renji Hospital, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, P. R. China.

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http://dx.doi.org/10.1002/smll.202001177DOI Listing
September 2020

DNA hydrogel-based gene editing and drug delivery systems.

Adv Drug Deliv Rev 2020 Jul 23. Epub 2020 Jul 23.

Institute of Cancer and Basic Medicine (IBMC), Chinese Academy of Sciences, The Cancer Hospital of the University of Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China. Electronic address:

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http://dx.doi.org/10.1016/j.addr.2020.07.018DOI Listing
July 2020

Aptamer-Directed Protein-Specific Multiple Modifications of Membrane Glycoproteins on Living Cells.

ACS Appl Mater Interfaces 2020 Aug 13;12(34):37845-37850. Epub 2020 Aug 13.

Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan 410082, China.

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http://dx.doi.org/10.1021/acsami.0c07004DOI Listing
August 2020

Transducing Complex Biomolecular Interactions by Temperature-Output Artificial DNA Signaling Networks.

J Am Chem Soc 2020 Aug 11;142(33):14234-14239. Epub 2020 Aug 11.

Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Life Sciences, and Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan 410082, China.

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http://dx.doi.org/10.1021/jacs.0c05453DOI Listing
August 2020

Photorelease of Pyridines Using a Metal-Free Photoremovable Protecting Group.

Angew Chem Int Ed Engl 2020 Jul 15. Epub 2020 Jul 15.

Key Laboratory of Molecular Nanostructure and Nanotechnology, Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.

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http://dx.doi.org/10.1002/anie.202005310DOI Listing
July 2020

Circular Bispecific Aptamer-Mediated Artificial Intercellular Recognition for Targeted T Cell Immunotherapy.

ACS Nano 2020 08 22;14(8):9562-9571. Epub 2020 Jul 22.

Institute of Molecular Medicine (IMM), Renji Hospital, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine, and College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.

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http://dx.doi.org/10.1021/acsnano.9b09884DOI Listing
August 2020

Imaging of peroxynitrite in drug-induced acute kidney injury with a near-infrared fluorescence and photoacoustic dual-modal molecular probe.

Chem Commun (Camb) 2020 Jul 17;56(58):8103-8106. Epub 2020 Jun 17.

Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.

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http://dx.doi.org/10.1039/d0cc01621gDOI Listing
July 2020

Conformational Conversion Enhances Cellular Uptake of F Base Double-Strand-Conjugated Oligonucleotides.

Anal Chem 2020 08 13;92(15):10375-10380. Epub 2020 Jul 13.

Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan 410082, China.

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http://dx.doi.org/10.1021/acs.analchem.0c00614DOI Listing
August 2020

Aptamers as Versatile Molecular Tools for Antibody Production Monitoring and Quality Control.

J Am Chem Soc 2020 Jul 29;142(28):12079-12086. Epub 2020 Jun 29.

Institute of Molecular Medicine (IMM), State Key Laboratory of Oncogenes and Related Genes, Renji Hospital, Shanghai Jiao Tong University School of Medicine, and College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.

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http://dx.doi.org/10.1021/jacs.9b13370DOI Listing
July 2020

Aptamer Enables Consistent Maytansine Delivery through Maintaining Receptor Homeostasis for HER2 Targeted Cancer Therapy.

Bioconjug Chem 2020 Jul 15;31(7):1766-1774. Epub 2020 Jun 15.

Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, and Aptamer Engineering Center of Hunan Province, Hunan University, Changsha 410082, People's Republic of China.

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http://dx.doi.org/10.1021/acs.bioconjchem.0c00250DOI Listing
July 2020

MicroRNA-Initiated and Intracellular Na-Fueled DNAzyme Motor for Differentiating Molecular Subtypes of Nonsmall Cell Lung Cancer.

Anal Chem 2020 06 20;92(11):7404-7408. Epub 2020 May 20.

Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Life Sciences, and Aptamer Engineering Center of Hunan Province, Hunan University, Changsha 410082, China.

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http://dx.doi.org/10.1021/acs.analchem.0c01134DOI Listing
June 2020

Nucleic Acid Aptamers for Molecular Diagnostics and Therapeutics: Advances and Perspectives.

Angew Chem Int Ed Engl 2020 Apr 13. Epub 2020 Apr 13.

Department of Chemistry and Physiology and Functional Genomics, Center for Research at the Bio/Nano Interface, Health Cancer Center, UF Genetics Institute, McKnight Brain Institute, University of Florida, Gainesville, Florida, 32611, USA.

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http://dx.doi.org/10.1002/anie.202003563DOI Listing
April 2020

Adipose specific aptamer adipo-8 recognizes and interacts with APMAP to ameliorates fat deposition in vitro and in vivo.

Life Sci 2020 Jun 6;251:117609. Epub 2020 Apr 6.

Xiangya Hospital, Central South University, Changsha, Hunan 410008, China. Electronic address:

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http://dx.doi.org/10.1016/j.lfs.2020.117609DOI Listing
June 2020

Size-selective molecular recognition based on a confined DNA molecular sieve using cavity-tunable framework nucleic acids.

Nat Commun 2020 03 23;11(1):1518. Epub 2020 Mar 23.

Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, 410082, Changsha, China.

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http://dx.doi.org/10.1038/s41467-020-15297-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089997PMC
March 2020

Tumor microenvironment (TME)-activatable circular aptamer-PEG as an effective hierarchical-targeting molecular medicine for photodynamic therapy.

Biomaterials 2020 Jul 14;246:119971. Epub 2020 Mar 14.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2020.119971DOI Listing
July 2020

Equipping Natural Killer Cells with Specific Targeting and Checkpoint Blocking Aptamers for Enhanced Adoptive Immunotherapy in Solid Tumors.

Angew Chem Int Ed Engl 2020 07 12;59(29):12022-12028. Epub 2020 May 12.

Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, The Cancer Hospital of the University of Chinese Academy of Sciences, Hangzhou, Zhejiang, 310022, China.

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http://dx.doi.org/10.1002/anie.202002145DOI Listing
July 2020

Molecular domino reactor built by automated modular synthesis for cancer treatment.

Theranostics 2020 4;10(9):4030-4041. Epub 2020 Mar 4.

Institute of Molecular Medicine (IMM), Renji Hospital, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine, and College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.

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http://dx.doi.org/10.7150/thno.43581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086356PMC
March 2020

Construction of Bispecific Aptamer-Drug Conjugate by a Hybrid Chemical and Biological Approach.

Bioconjug Chem 2020 05 7;31(5):1289-1294. Epub 2020 Apr 7.

Institute of Molecular Medicine (IMM), Renji Hospital State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine, and College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University Shanghai 200240, China.

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http://dx.doi.org/10.1021/acs.bioconjchem.0c00071DOI Listing
May 2020

Aptamer-based optical manipulation of protein subcellular localization in cells.

Nat Commun 2020 03 12;11(1):1347. Epub 2020 Mar 12.

Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Collaborative Innovation Center for Chemistry and Molecular Medicine, Hunan University, Changsha, 410082, China.

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http://dx.doi.org/10.1038/s41467-020-15113-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067792PMC
March 2020

DNA-Modulated Plasmon Resonance: Methods and Optical Applications.

ACS Appl Mater Interfaces 2020 Apr 17;12(13):14741-14760. Epub 2020 Mar 17.

State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha 410082, P. R. China.

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http://dx.doi.org/10.1021/acsami.9b23608DOI Listing
April 2020

A programmable polymer library that enables the construction of stimuli-responsive nanocarriers containing logic gates.

Nat Chem 2020 Apr 9;12(4):381-390. Epub 2020 Mar 9.

Institute of Molecular Medicine (IMM), Renji Hospital, Shanghai Jiao Tong University School of Medicine, and College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China.

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http://dx.doi.org/10.1038/s41557-020-0426-3DOI Listing
April 2020

DNA-based artificial molecular signaling system that mimics basic elements of reception and response.

Nat Commun 2020 02 20;11(1):978. Epub 2020 Feb 20.

Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, and Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan, 410082, People's Republic of China.

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http://dx.doi.org/10.1038/s41467-020-14739-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033183PMC
February 2020

A molecular recognition-activatable DNA nanofirecracker enables signal-enhanced imaging in living cells.

Chem Commun (Camb) 2020 Mar;56(21):3131-3134

Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.

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http://dx.doi.org/10.1039/c9cc09682eDOI Listing
March 2020

Improving Tumor Accumulation of Aptamers by Prolonged Blood Circulation.

Anal Chem 2020 03 20;92(5):4108-4114. Epub 2020 Feb 20.

Institute of Molecular Medicine (IMM), Renji Hospital, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine, and College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.

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http://dx.doi.org/10.1021/acs.analchem.9b05878DOI Listing
March 2020

Biomineralized nanoparticles enable an enzyme-assisted DNA signal amplification in living cells.

Chem Commun (Camb) 2020 Mar;56(19):2901-2904

Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and Molecular Medicine, Hunan University, Changsha 410082, P. R. China.

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http://dx.doi.org/10.1039/c9cc09503aDOI Listing
March 2020

Programmable pH-Responsive DNA Nanosensors for Imaging Exocytosis and Retrieval of Synaptic Vesicles.

Anal Chem 2020 03 17;92(5):3620-3626. Epub 2020 Feb 17.

Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, and Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan 410082, P. R. China.

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http://dx.doi.org/10.1021/acs.analchem.9b04493DOI Listing
March 2020

Enhanced in Vivo Blood-Brain Barrier Penetration by Circular Tau-Transferrin Receptor Bifunctional Aptamer for Tauopathy Therapy.

J Am Chem Soc 2020 02 11;142(8):3862-3872. Epub 2020 Feb 11.

Department of Chemistry and Department of Physiology and Functional Genomics, Center for Research at Bio/Nano Interface, Health Cancer Center, UF Genetics Institute and McKnight Brain Institute , University of Florida , Gainesville , Florida 32611 , United States.

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http://dx.doi.org/10.1021/jacs.9b11490DOI Listing
February 2020

Learning from Artemisinin: Bioinspired Design of a Reaction-Based Fluorescent Probe for the Selective Sensing of Labile Heme in Complex Biosystems.

J Am Chem Soc 2020 02 23;142(5):2129-2133. Epub 2020 Jan 23.

Molecular Science and Biomedicine Laboratory, College of Chemistry and Chemical Engineering, State Key Laboratory of Chemo/Biosensing and Chemometrics, Collaborative Innovation Center for Chemistry and Molecular Medicine , Hunan University , Changsha 410082 , P. R. China.

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http://dx.doi.org/10.1021/jacs.9b11245DOI Listing
February 2020

Human serum albumin as an intrinsic signal amplification amplifier for ultrasensitive assays of the prostate-specific antigen in human plasma.

Chem Commun (Camb) 2020 Feb;56(12):1843-1846

State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410114, P. R. China.

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http://dx.doi.org/10.1039/c9cc08501gDOI Listing
February 2020

Conjugating Aptamer and Mitomycin C with Reductant-Responsive Linker Leading to Synergistically Enhanced Anticancer Effect.

J Am Chem Soc 2020 02 22;142(5):2532-2540. Epub 2020 Jan 22.

Molecular Sciences and Biomedicine Laboratory (MBL), State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering and College of Biology, Collaborative Innovation Center for Chemistry and Molecular Medicine , Hunan University , Changsha 410082 , China.

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http://dx.doi.org/10.1021/jacs.9b12409DOI Listing
February 2020

Molecularly Engineering Triptolide with Aptamers for High Specificity and Cytotoxicity for Triple-Negative Breast Cancer.

J Am Chem Soc 2020 02 14;142(6):2699-2703. Epub 2020 Jan 14.

Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Aptamer Engineering Center of Hunan Province , Hunan University , Changsha 410082 , People's Republic of China.

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http://dx.doi.org/10.1021/jacs.9b10510DOI Listing
February 2020

Molecular Self-Assembly of Bioorthogonal Aptamer-Prodrug Conjugate Micelles for Hydrogen Peroxide and pH-Independent Cancer Chemodynamic Therapy.

J Am Chem Soc 2020 01 31;142(2):937-944. Epub 2019 Dec 31.

Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province , Hunan University , Changsha 410082 , China.

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http://dx.doi.org/10.1021/jacs.9b10755DOI Listing
January 2020

A Novel Small Molecule Inhibits Intrahepatocellular Accumulation of Z-Variant Alpha 1-Antitrypsin In Vitro and In Vivo.

Cells 2019 12 6;8(12). Epub 2019 Dec 6.

Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL 32611, USA.

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http://dx.doi.org/10.3390/cells8121586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953066PMC
December 2019

Polymeric Engineering of Aptamer-Drug Conjugates for Targeted Cancer Therapy.

Bioconjug Chem 2020 01 16;31(1):37-42. Epub 2019 Dec 16.

Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province , Hunan University , Changsha , Hunan 410082 , China.

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http://dx.doi.org/10.1021/acs.bioconjchem.9b00715DOI Listing
January 2020

In Vivo Monocyte/Macrophage-Hitchhiked Intratumoral Accumulation of Nanomedicines for Enhanced Tumor Therapy.

J Am Chem Soc 2020 01 17;142(1):382-391. Epub 2019 Dec 17.

Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, and Aptamer Engineering Center of Hunan Province , Hunan University , Changsha , Hunan 410082 , China.

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http://dx.doi.org/10.1021/jacs.9b11046DOI Listing
January 2020

Metabolic Labeling of Peptidoglycan with NIR-II Dye Enables In Vivo Imaging of Gut Microbiota.

Angew Chem Int Ed Engl 2020 02 9;59(7):2628-2633. Epub 2020 Jan 9.

Institute of Molecular Medicine (IMM), Renji Hospital, Shanghai Jiao Tong University School of Medicine, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 200127, China.

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http://dx.doi.org/10.1002/anie.201910555DOI Listing
February 2020

E-jet 3D printed drug delivery implants to inhibit growth and metastasis of orthotopic breast cancer.

Biomaterials 2020 02 13;230:119618. Epub 2019 Nov 13.

College of Biology, Hunan University, Changsha, Hunan, 410082, China; Shenzhen Institute, Hunan University, Shenzhen, Guangdong, 410082, China. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2019.119618DOI Listing
February 2020

DNA-Capped Silver Nanoflakes as Fluorescent Nanosensor for Highly Sensitive Imaging of Endogenous HS in Cell Division Cycles.

Anal Chem 2019 12 6;91(24):15404-15410. Epub 2019 Dec 6.

Molecular Science and Biomedicine Laboratory, State Key Laboratory for Chemo/Bio Sensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, and Collaborative Research Center of Molecular Engineering for Theranostics , Hunan University , Changsha 410082 , China.

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http://dx.doi.org/10.1021/acs.analchem.9b02527DOI Listing
December 2019

Biomimetic Carriers Based on Giant Membrane Vesicles for Targeted Drug Delivery and Photodynamic/Photothermal Synergistic Therapy.

ACS Appl Mater Interfaces 2019 Nov 18;11(47):43811-43819. Epub 2019 Nov 18.

Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province , Hunan University , Changsha , Hunan 410082 , China.

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http://dx.doi.org/10.1021/acsami.9b11223DOI Listing
November 2019

3D halos assembled from FeO/Au NPs with enhanced catalytic and optical properties.

Nanoscale 2019 Nov 29;11(43):20968-20976. Epub 2019 Oct 29.

Molecular Sciences and Biomedicine Laboratory (MBL), State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering and College of Biology, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha 410082, China. and Institute of Molecular Medicine (IMM), State Key Laboratory of Oncogenes and Related Genes Renji Hospital, Shanghai Jiao Tong University School of Medicine, and College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China and Department of Chemistry and Department of Physiology and Functional Genomics, Center for Research at the Bio/Nano Interface, Shands Cancer Center, UF Genetics Institute, McKnight Brain Institute, University of Florida, Gainesville, FL 32611-7200, USA.

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http://dx.doi.org/10.1039/c9nr05874eDOI Listing
November 2019

An Aptamer-Nanotrain Assembled from Six-Letter DNA Delivers Doxorubicin Selectively to Liver Cancer Cells.

Angew Chem Int Ed Engl 2020 01 19;59(2):663-668. Epub 2019 Nov 19.

Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan, 410082, China.

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http://dx.doi.org/10.1002/anie.201909691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157901PMC
January 2020

Naked-Eye Readout of Analyte-Induced NIR Fluorescence Responses by an Initiation-Input-Transduction Nanoplatform.

Angew Chem Int Ed Engl 2020 01 27;59(2):695-699. Epub 2019 Nov 27.

Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, 410082, China.

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http://dx.doi.org/10.1002/anie.201911113DOI Listing
January 2020

Cell-Membrane-Anchored DNA Nanoplatform for Programming Cellular Interactions.

J Am Chem Soc 2019 11 1;141(45):18013-18020. Epub 2019 Nov 1.

Molecular Science and Biomedicine Laboratory, State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Life Sciences, and Aptamer Engineering Center of Hunan Province , Hunan University , Changsha , Hunan 410082 , China.

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http://dx.doi.org/10.1021/jacs.9b04725DOI Listing
November 2019

Engineering Aptamer with Enhanced Affinity by Triple Helix-Based Terminal Fixation.

J Am Chem Soc 2019 11 28;141(44):17493-17497. Epub 2019 Oct 28.

Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/BioSensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, and Aptamer Engineering Center of Hunan Province , Hunan University , Changsha , Hunan 410082 , China.

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http://dx.doi.org/10.1021/jacs.9b09292DOI Listing
November 2019

Endocytic Pathways and Intracellular Transport of Aptamer-Drug Conjugates in Live Cells Monitored by Single-Particle Tracking.

Anal Chem 2019 11 24;91(21):13818-13823. Epub 2019 Oct 24.

Institute of Molecular Medicine (IMM), State Key Laboratory of Oncogenes and Related Genes Renji Hospital, Shanghai Jiao Tong University School of Medicine, and College of Chemistry and Chemical Engineering , Shanghai Jiao Tong University , Shanghai 200240 , China.

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http://dx.doi.org/10.1021/acs.analchem.9b03281DOI Listing
November 2019

Tumor Extracellular pH-Driven Cancer-Selective Artificial Receptor-Mediated Tumor-Targeted Fluorescence Imaging.

Anal Chem 2019 11 11;91(21):13349-13354. Epub 2019 Oct 11.

Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Life Sciences, and Aptamer Engineering Center of Hunan Province , Hunan University , Changsha 410082 , China.

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https://pubs.acs.org/doi/10.1021/acs.analchem.9b03779
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http://dx.doi.org/10.1021/acs.analchem.9b03779DOI Listing
November 2019

Hypoxia-Activated PEGylated Conditional Aptamer/Antibody for Cancer Imaging with Improved Specificity.

J Am Chem Soc 2019 11 7;141(46):18421-18427. Epub 2019 Nov 7.

Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, and Aptamer Engineering Center of Hunan Province , Hunan University , Changsha 410082 , P. R. China.

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http://dx.doi.org/10.1021/jacs.9b05063DOI Listing
November 2019

Generating Giant Membrane Vesicles from Live Cells with Preserved Cellular Properties.

Research (Wash D C) 2019 17;2019:6523970. Epub 2019 Jun 17.

Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, China.

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http://dx.doi.org/10.34133/2019/6523970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750080PMC
June 2019

Aptamer Displacement Reaction from Live-Cell Surfaces and Its Applications.

J Am Chem Soc 2019 10 16;141(43):17174-17179. Epub 2019 Oct 16.

Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Aptamer Engineering Center of Hunan Province , Hunan University , Changsha 410082 , China.

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http://dx.doi.org/10.1021/jacs.9b07191DOI Listing
October 2019

Monitoring Telomerase Activity in Living Cells with High Sensitivity Using Cascade Amplification Reaction-Based Nanoprobe.

Anal Chem 2019 10 24;91(20):13143-13151. Epub 2019 Sep 24.

Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and Molecular Medicine , Hunan University , Changsha 410082 , China.

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http://dx.doi.org/10.1021/acs.analchem.9b03410DOI Listing
October 2019

Aptamer Selection for Detecting Molecular Target Using Cell-SELEX (Systematic Evolution of Ligands by Exponential Enrichment) Technology.

Methods Mol Biol 2019 ;2054:223-241

Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.

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http://dx.doi.org/10.1007/978-1-4939-9769-5_15DOI Listing
June 2020

A Metal-Organic Framework as Selectivity Regulator for Fe and Ascorbic Acid Detection.

Anal Chem 2019 10 9;91(19):12453-12460. Epub 2019 Sep 9.

Center for Research at Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Health Cancer Center, UF Genetics Institute and McKnight Brain Institute , University of Florida , Gainesville , Florida 32611-7200 , United States.

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http://dx.doi.org/10.1021/acs.analchem.9b03143DOI Listing
October 2019

CRISPR propels a smart hydrogel.

Science 2019 08;365(6455):754-755

Institute of Molecular Medicine (IMM), Renji Hospital, Shanghai Jiao Tong University School of Medicine, and College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.

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http://dx.doi.org/10.1126/science.aay4198DOI Listing
August 2019

NIR-II Driven Plasmon-Enhanced Catalysis for a Timely Supply of Oxygen to Overcome Hypoxia-Induced Radiotherapy Tolerance.

Angew Chem Int Ed Engl 2019 10 11;58(42):15069-15075. Epub 2019 Sep 11.

Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, P. R. China.

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http://dx.doi.org/10.1002/anie.201906758DOI Listing
October 2019

Nitric Oxide-Activated "Dual-Key-One-Lock" Nanoprobe for in Vivo Molecular Imaging and High-Specificity Cancer Therapy.

J Am Chem Soc 2019 08 13;141(34):13572-13581. Epub 2019 Aug 13.

Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering , Hunan University , Changsha 410082 , P. R. China.

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http://dx.doi.org/10.1021/jacs.9b05901DOI Listing
August 2019

Construction of a Multiple-Aptamer-Based DNA Logic Device on Live Cell Membranes via Associative Toehold Activation for Accurate Cancer Cell Identification.

J Am Chem Soc 2019 08 1;141(32):12738-12743. Epub 2019 Aug 1.

Institute of Molecular Medicine, Renji Hospital, School of Medicine , Shanghai Jiao Tong University , Shanghai , 200127 , China.

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http://dx.doi.org/10.1021/jacs.9b05470DOI Listing
August 2019

DNA-supramolecule conjugates in theranostics.

Theranostics 2019 18;9(11):3262-3279. Epub 2019 May 18.

Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Life Sciences, and Aptamer Engineering Center of Hunan Province, Hunan University, Changsha 410082, China.

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http://dx.doi.org/10.7150/thno.31885DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567960PMC
July 2020

Interaction-Transferable Graphene-Isolated Superstable AuCo Nanocrystal-Enabled Direct Cyanide Capture.

Anal Chem 2019 07 26;91(14):8762-8766. Epub 2019 Jun 26.

Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology , Hunan University , Changsha 410082 , China.

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http://dx.doi.org/10.1021/acs.analchem.9b01811DOI Listing
July 2019

A new small cell lung cancer biomarker identified by Cell-SELEX generated aptamers.

Exp Cell Res 2019 09 21;382(2):111478. Epub 2019 Jun 21.

Beijing National Research Center for Molecular Sciences, Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, PR China; University of Chinese Academy of Sciences, Beijing, 100049, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.yexcr.2019.06.023DOI Listing
September 2019

Phosphorylated lipid-conjugated oligonucleotide selectively anchors on cell membranes with high alkaline phosphatase expression.

Nat Commun 2019 06 20;10(1):2704. Epub 2019 Jun 20.

Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Life Sciences, Aptamer Engineering Center of Hunan Province, Hunan University, 410082, Changsha, Hunan, China.

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http://dx.doi.org/10.1038/s41467-019-10639-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586821PMC
June 2019

Anticancer-Active N-Heteroaryl Amines Syntheses: Nucleophilic Amination of N-Heteroaryl Alkyl Ethers with Amines.

Org Lett 2019 07 14;21(13):5111-5115. Epub 2019 Jun 14.

Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, and Aptamer Engineering Center of Hunan Province , Hunan University , Changsha , Hunan 410082 , P. R. China.

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http://dx.doi.org/10.1021/acs.orglett.9b01711DOI Listing
July 2019

Free-standing 2D nanorafts by assembly of 1D nanorods for biomolecule sensing.

Nanoscale 2019 Jul 14;11(25):12169-12176. Epub 2019 Jun 14.

Molecular Sciences and Biomedicine Laboratory (MBL), State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering and College of Biology, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha 410082, China. and Department of Chemistry and Department of Physiology and Functional Genomics, Center for Research at the Bio/Nano Interface, Shands Cancer Center, UF Genetics Institute, McKnight Brain Institute, University of Florida, Gainesville, FL 32611-7200, USA and Institute of Molecular Medicine (IMM), Renji Hospital, Shanghai Jiao Tong University School of Medicine, and College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China.

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http://dx.doi.org/10.1039/c9nr02636cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625510PMC
July 2019

Elucidation and Structural Modeling of CD71 as a Molecular Target for Cell-Specific Aptamer Binding.

J Am Chem Soc 2019 07 1;141(27):10760-10769. Epub 2019 Jul 1.

Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province , Hunan University , Changsha , Hunan 410082 , China.

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http://dx.doi.org/10.1021/jacs.9b03720DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625514PMC
July 2019

Sequential Protein-Responsive Nanophotosensitizer Complex for Enhancing Tumor-Specific Therapy.

ACS Nano 2019 06 7;13(6):6702-6710. Epub 2019 Jun 7.

Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and Molecular Medicine , Hunan University , Changsha 410082 , China.

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http://dx.doi.org/10.1021/acsnano.9b01100DOI Listing
June 2019

Identification and Application of an Aptamer Targeting Papillary Thyroid Carcinoma Using Tissue-SELEX.

Anal Chem 2019 07 12;91(13):8289-8297. Epub 2019 Jun 12.

Xiangya Hospital , Central South University , Changsha , Hunan 410008 , China.

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July 2019

Improving early detection of cancers by profiling extracellular vesicles.

Expert Rev Proteomics 2019 07 3;16(7):545-547. Epub 2019 Jun 3.

a Institute of Molecular Medicine, Renji Hospital , Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University , Shanghai , China.

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https://www.tandfonline.com/doi/full/10.1080/14789450.2019.1
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July 2019

Molecular Engineering-Based Aptamer-Drug Conjugates with Accurate Tunability of Drug Ratios for Drug Combination Targeted Cancer Therapy.

Angew Chem Int Ed Engl 2019 08 19;58(34):11661-11665. Epub 2019 Jul 19.

Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Life Sciences, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, 410082, P. R. China.

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http://dx.doi.org/10.1002/anie.201903807DOI Listing
August 2019

Monitorable Mitochondria-Targeting DNAtrain for Image-Guided Synergistic Cancer Therapy.

Anal Chem 2019 06 17;91(11):6996-7000. Epub 2019 May 17.

Guangdong Key Laboratory of Nanomedicine, CAS Key Laboratory of Health Informatics, Shenzhen Bioactive Materials Engineering Lab for Medicine, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology , Chinese Academy of Sciences , Shenzhen , Guangdong 518055 , P. R. China.

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http://dx.doi.org/10.1021/acs.analchem.9b01777DOI Listing
June 2019

Recent Progress in Small-Molecule Near-IR Probes for Bioimaging.

Trends Chem 2019 May 5;1(2):224-234. Epub 2019 Apr 5.

Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.

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http://dx.doi.org/10.1016/j.trechm.2019.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453910PMC
May 2019

Engineering Self-Calibrating Nanoprobes with Two-Photon-Activated Fluorescence Resonance Energy Transfer for Ratiometric Imaging of Biological Selenocysteine.

ACS Appl Mater Interfaces 2019 May 6;11(19):17722-17729. Epub 2019 May 6.

Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Aptamer Engineering Center of Hunan Province , Hunan University , Changsha 410082 , China.

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http://pubs.acs.org/doi/10.1021/acsami.9b04555
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May 2019

Identification of Vigilin as a Potential Ischemia Biomarker by Brain Slice-Based Systematic Evolution of Ligands by Exponential Enrichment.

Anal Chem 2019 05 1;91(10):6675-6681. Epub 2019 May 1.

Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Aptamer Engineering Center of Hunan Province , Hunan University Changsha , Hunan , 410082 , China.

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http://pubs.acs.org/doi/10.1021/acs.analchem.9b00609
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625766PMC
May 2019

Ostwald Ripening-Mediated Grafting of Metal-Organic Frameworks on a Single Colloidal Nanocrystal to Form Uniform and Controllable MXF.

J Am Chem Soc 2019 05 30;141(18):7407-7413. Epub 2019 Apr 30.

Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology , Hunan University , Changsha , 410082 , P. R. China.

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http://pubs.acs.org/doi/10.1021/jacs.9b01563
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May 2019

Recent Advances in Amphiphilic Polymer-Oligonucleotide Nanomaterials via Living/Controlled Polymerization Technologies.

Bioconjug Chem 2019 07 19;30(7):1889-1904. Epub 2019 Apr 19.

Departments of Chemistry, Materials Science & Engineering, and Biomedical Engineering, International Institute for Nanotechnology, and Simpson Querrey Institute , Northwestern University , 2145 Sheridan Road , Evanston , Illinois 60208-3113 , United States.

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http://dx.doi.org/10.1021/acs.bioconjchem.9b00166DOI Listing
July 2019

Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers.

Nat Biomed Eng 2019 03 21;3(3):183-193. Epub 2019 Jan 21.

Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering and College of Biology, Collaborative Innovation Center for Chemistry and Molecular Medicine, Hunan University, Changsha, China.

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http://dx.doi.org/10.1038/s41551-018-0343-6DOI Listing
March 2019

Enolase1 Alleviates Cerebral Ischemia-Induced Neuronal Injury via Its Enzymatic Product Phosphoenolpyruvate.

ACS Chem Neurosci 2019 06 16;10(6):2877-2889. Epub 2019 Apr 16.

Shenzhen Research Institute , Hunan University , Shenzhen , Guangdong 518000 , China.

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http://dx.doi.org/10.1021/acschemneuro.9b00103DOI Listing
June 2019

Artificial Signal Feedback Network Mimicking Cellular Adaptivity.

J Am Chem Soc 2019 04 16;141(16):6458-6461. Epub 2019 Apr 16.

Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Aptamer Engineering Center of Hunan Province , Hunan University , Changsha Hunan , 410082 , China.

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http://dx.doi.org/10.1021/jacs.8b13816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6673657PMC
April 2019

Hybridization chain reaction-based nanoprobe for cancer cell recognition and amplified photodynamic therapy.

Chem Commun (Camb) 2019 Mar;55(21):3065-3068

Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China.

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http://dx.doi.org/10.1039/c8cc10074hDOI Listing
March 2019

Engineering of Bioinspired, Size-Controllable, Self-Degradable Cancer-Targeting DNA Nanoflowers via the Incorporation of an Artificial Sandwich Base.

J Am Chem Soc 2019 03 5;141(10):4282-4290. Epub 2019 Mar 5.

Molecular Science and Biomedicine Laboratory , State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Life Sciences, and Aptamer Engineering Center of Hunan Province, Hunan University , Changsha , Hunan 410082 , China.

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http://dx.doi.org/10.1021/jacs.8b10795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625512PMC
March 2019

In Situ Amplification-Based Imaging of RNA in Living Cells.

Angew Chem Int Ed Engl 2019 08 14;58(34):11574-11585. Epub 2019 May 14.

School of Chemistry and Food Engineering, Changsha University of Science and Technology, Changsha, 410114, China.

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http://dx.doi.org/10.1002/anie.201812449DOI Listing
August 2019

Smart Nanodrug with Nuclear Localization Sequences in the Presence of MMP-2 To Overcome Biobarriers and Drug Resistance.

Chemistry 2019 Feb 25;25(8):1895-1900. Epub 2019 Jan 25.

Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan, 410082, P. R. China.

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http://doi.wiley.com/10.1002/chem.201805107
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http://dx.doi.org/10.1002/chem.201805107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447044PMC
February 2019

Visible Light-Driven Self-Powered Device Based on a Straddling Nano-Heterojunction and Bio-Application for the Quantitation of Exosomal RNA.

ACS Nano 2019 02 25;13(2):1817-1827. Epub 2019 Jan 25.

Center for Research at the Bio/nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, UF Genetics Institute and McKnight Brain Institute, Shands Cancer Center , University of Florida , Gainesville , Florida 32611-7200 , United States.

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http://dx.doi.org/10.1021/acsnano.8b07944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613566PMC
February 2019

Facile approach to prepare HSA-templated MnO nanosheets as oxidase mimic for colorimetric detection of glutathione.

Talanta 2019 Apr 10;195:40-45. Epub 2018 Nov 10.

Center for Research at Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL 32611-7200, United States; State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, and College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China. Electronic address:

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http://dx.doi.org/10.1016/j.talanta.2018.11.024DOI Listing
April 2019

Aptamer-Functionalized Exosomes: Elucidating the Cellular Uptake Mechanism and the Potential for Cancer-Targeted Chemotherapy.

Anal Chem 2019 02 24;91(3):2425-2430. Epub 2019 Jan 24.

Molecular Science and Biomedicine Laboratory, State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Life Sciences , Aptamer Engineering Center of Hunan Province, Hunan University , Changsha , Hunan 410082 , China.

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http://dx.doi.org/10.1021/acs.analchem.8b05204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662586PMC
February 2019

Generalized Preparation of Two-Dimensional Quasi-nanosheets via Self-assembly of Nanoparticles.

J Am Chem Soc 2019 01 15;141(4):1725-1734. Epub 2019 Jan 15.

Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Aptamer Engineering Center of Hunan Province , Hunan University Changsha , Hunan 410082 , China.

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http://pubs.acs.org/doi/10.1021/jacs.8b12415
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625513PMC
January 2019

Regulation of Protein Activity and Cellular Functions Mediated by Molecularly Evolved Nucleic Acids.

Angew Chem Int Ed Engl 2019 02 14;58(6):1621-1625. Epub 2019 Jan 14.

Molecular Science and Biomedicine Laboratory (MBL), Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, 410082, China.

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http://dx.doi.org/10.1002/anie.201809010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442720PMC
February 2019

Artificial Sandwich Base for Monitoring Single-Nucleobase Changes and Charge-Transfer Rates in DNA.

Anal Chem 2019 02 8;91(3):2074-2078. Epub 2019 Jan 8.

Institute of Molecular Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, and College of Chemistry and Chemical Engineering , Shanghai Jiao Tong University , Shanghai 200240 , China.

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http://dx.doi.org/10.1021/acs.analchem.8b04513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625767PMC
February 2019

Chelation-assisted assembly of multidentate colloidal nanoparticles into metal-organic nanoparticles.

Nanoscale 2018 Dec 14;10(45):21369-21373. Epub 2018 Nov 14.

Department of Chemistry and Physiology and Functional Genomics, Center for Research at the Bio/Nano Interface, Health Cancer Center, University of Florida, Gainesville, FL 32611-7200, USA.

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http://xlink.rsc.org/?DOI=C8NR06262E
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http://dx.doi.org/10.1039/c8nr06262eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442733PMC
December 2018

Self-Assembled Aptamer-Grafted Hyperbranched Polymer Nanocarrier for Targeted and Photoresponsive Drug Delivery.

Angew Chem Int Ed Engl 2018 12 26;57(52):17048-17052. Epub 2018 Nov 26.

Center for Research at Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, UF Health Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL, 32611-7200, USA.

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http://doi.wiley.com/10.1002/anie.201809753
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442708PMC
December 2018

Portable and Label-Free Detection of Blood Bilirubin with Graphene-Isolated-Au-Nanocrystals Paper Strip.

Anal Chem 2018 11 31;90(22):13687-13694. Epub 2018 Oct 31.

Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering and College of Life Sciences, Aptamer Engineering Center of Hunan Province , Hunan University , Changsha Hunan 410082 , China.

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http://dx.doi.org/10.1021/acs.analchem.8b04058DOI Listing
November 2018

ZrMOF nanoparticles as quenchers to conjugate DNA aptamers for target-induced bioimaging and photodynamic therapy.

Chem Sci 2018 Oct 30;9(38):7505-7509. Epub 2018 Jul 30.

Molecular Science and Biomedicine Laboratory (MBL) , State Key Laboratory of Chemo/Bio-Sensing and Chemometrics , College of Biology , College of Chemistry and Chemical Engineering , Hunan University , Changsha , 410082 , China . Email: ; Email:

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http://xlink.rsc.org/?DOI=C8SC02210K
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179088PMC
October 2018

G-Quadruplex-Based Nanoscale Coordination Polymers to Modulate Tumor Hypoxia and Achieve Nuclear-Targeted Drug Delivery for Enhanced Photodynamic Therapy.

Nano Lett 2018 11 10;18(11):6867-6875. Epub 2018 Oct 10.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences , University of Macau , Avenida da Universidade , Taipa , Macau , China.

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http://pubs.acs.org/doi/10.1021/acs.nanolett.8b02732
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November 2018

"Trojan Horse" DNA Nanostructure for Personalized Theranostics: Can It Knock on the Door of Preclinical Practice?

Langmuir 2018 12 5;34(49):15028-15044. Epub 2018 Nov 5.

State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering , Hunan University , Changsha 410082 , P. R. China.

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http://dx.doi.org/10.1021/acs.langmuir.8b02008DOI Listing
December 2018

Identification and Characterization of DNA Aptamers Specific for Phosphorylation Epitopes of Tau Protein.

J Am Chem Soc 2018 10 16;140(43):14314-14323. Epub 2018 Oct 16.

Department of Chemistry, Department of Physiology and Functional Genomics, Center for Research at Bio/Nano Interface, UF Health Cancer Center , UF Genetics Institute and McKnight Brain Institute, University of Florida , Gainesville , Florida 32611-7200 , United States.

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http://pubs.acs.org/doi/10.1021/jacs.8b08645
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442731PMC
October 2018

Construction of self-powered cytosensing device based on ZnO nanodisks@g-CN quantum dots and application in the detection of CCRF-CEM cells.

Nano Energy 2018 Apr 31;46:101-109. Epub 2018 Jan 31.

Center for Research at the Bio/nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, UF Genetics Institute and McKnight Brain Institute, Shands Cancer Center, University of Florida, Gainesville, FL 32611-7200, United States.

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https://linkinghub.elsevier.com/retrieve/pii/S22112855183002
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157620PMC
April 2018