Publications by authors named "Weiguo Xiang"

9Publications

The 3-D conformational shape of N-naphthyl-cyclopenta[d]pyrimidines affects their potency as microtubule targeting agents and their antitumor activity.

Bioorg Med Chem 2021 Jan 24;29:115887. Epub 2020 Nov 24.

Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, PA 15282, United States. Electronic address:

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January 2021

Discovery of Highly Potent and Efficient PROTAC Degraders of Androgen Receptor (AR) by Employing Weak Binding Affinity VHL E3 Ligase Ligands.

J Med Chem 2019 12 5;62(24):11218-11231. Epub 2019 Dec 5.

School of Pharmaceutical Sciences and Institute of Drug Discovery & Development , Zhengzhou University , Zhengzhou 450001 , China.

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December 2019

Discovery of amide-bridged pyrrolo[2,3-d]pyrimidines as tumor targeted classical antifolates with selective uptake by folate receptor α and inhibition of de novo purine nucleotide biosynthesis.

Bioorg Med Chem 2019 12 17;27(23):115125. Epub 2019 Oct 17.

Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, PA 15282, United States. Electronic address:

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December 2019

MCL-1 inhibition in cancer treatment.

Onco Targets Ther 2018 23;11:7301-7314. Epub 2018 Oct 23.

Department of Internal Medicine, University of Michigan Medical School,

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October 2018

Structure based drug design and in vitro metabolism study: Discovery of N-(4-methylthiophenyl)-N,2-dimethyl-cyclopenta[d]pyrimidine as a potent microtubule targeting agent.

Bioorg Med Chem 2018 05 4;26(9):2437-2451. Epub 2018 Apr 4.

Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, PA 15282, United States. Electronic address:

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May 2018

The coronary anomaly: right coronary artery originates from the mid left anterior descending artery.

J Invasive Cardiol 2010 Sep;22(9):E166-7

First Affiliated Hospital of Tsinghua University, Beijing, China.

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September 2010