Publications by authors named "Weidong Wu"

257 Publications

Forecasting the Tuberculosis Incidence Using a Novel Ensemble Empirical Mode Decomposition-Based Data-Driven Hybrid Model in Tibet, China.

Infect Drug Resist 2021 25;14:1941-1955. Epub 2021 May 25.

Department of Epidemiology and Health Statistics, School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, People's Republic of China.

Objective: The purpose of this study is to develop a novel data-driven hybrid model by fusing ensemble empirical mode decomposition (EEMD), seasonal autoregressive integrated moving average (SARIMA), with nonlinear autoregressive artificial neural network (NARNN), called EEMD-ARIMA-NARNN model, to assess and forecast the epidemic patterns of TB in Tibet.

Methods: The TB incidence from January 2006 to December 2017 was obtained, and then the time series was partitioned into training subsamples (from January 2006 to December 2016) and testing subsamples (from January to December 2017). Among them, the training set was used to develop the EEMD-SARIMA-NARNN combined model, whereas the testing set was used to validate the forecasting performance of the model. Whilst the forecasting accuracy level of this novel method was compared with the basic SARIMA model, basic NARNN model, error-trend-seasonal (ETS) model, and traditional SARIMA-NARNN mixture model.

Results: By comparing the accuracy level of the forecasting measurements including root-mean-square error, mean absolute deviation, mean error rate, mean absolute percentage error, and root-mean-square percentage error, it was shown that the EEMD-SARIMA-NARNN combined method produced lower error rates than the others. The descriptive statistics suggested that TB was a seasonal disease, peaking in late winter and early spring and a trough in autumn and early winter, and the TB epidemic indicated a drastic increase by a factor of 1.7 from 2006 to 2017 in Tibet, with average annual percentage change of 5.8 (95% confidence intervals: 3.5-8.1).

Conclusion: This novel data-driven hybrid method can better consider both linear and nonlinear components in the TB incidence than the others used in this study, which is of great help to estimate and forecast the future epidemic trends of TB in Tibet. Besides, under present trends, strict precautionary measures are required to reduce the spread of TB in Tibet.
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http://dx.doi.org/10.2147/IDR.S299704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164697PMC
May 2021

Hypoxic tumor-derived exosomal miR-31-5p promotes lung adenocarcinoma metastasis by negatively regulating SATB2-reversed EMT and activating MEK/ERK signaling.

J Exp Clin Cancer Res 2021 Jun 1;40(1):179. Epub 2021 Jun 1.

Department of Thoracic Surgery, Fujian Medical University Union Hospital, #29 Xinquan Road, 350001, Fuzhou, Fujian, China.

Background: Exosomes have emerged as critical mediators of intercellular communication. Hypoxia is widely recognized as a key regulator of tumor aggressiveness, and significantly affects exosome release by tumor cells. However, the effects of exosomes derived from hypoxic lung adenocarcinoma (LUAD) cells are poorly understood.

Methods: Samples of miRNA isolated from hypoxic LUAD cell-derived exosomes (HExo) and normoxic LUAD cell-derived exosomes (NExo) were sequenced to identify miRNAs that might mediate tumor progression. Exosomal miRNA was co-cultured with LUAD cells to assess its biological effects on cell migration and metastasis both in vitro and in vivo. The cellular target of exosomal miRNA was confirmed by dual-luciferase assays. Western blot studies showed that exosomal miRNA regulated the related pathway. The availability of circulating exosomal miRNA derived from plasma was also evaluated.

Results: We found that HExo could significantly enhance the migration and invasion of normoxic LUAD cells. MiRNA sequencing results suggested that miR-31-5p was largely internalized within HExo and could be taken up by normoxic LUAD cells. Exosomal miR-31-5p was found to directly target Special AT-Rich Sequence-Binding Protein 2 (SATB2)-revered epithelial mesenchymal transition and significantly increase activation of MEK/ERK signaling, thereby contributing to tumor progression both in vitro and in vivo. Furthermore, higher levels of circulating exosomal miR-31-5p were detected in LUAD patients, especially in patients with metastatic disease.

Conclusions: Our findings demonstrate that exosomal miR-31-5p exerts a crucial role in LUAD progression, and could serve as a diagnostic biomarker for LUAD.
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http://dx.doi.org/10.1186/s13046-021-01979-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167983PMC
June 2021

Fine particulate matter-induced lung inflammation is mediated by pyroptosis in mice.

Ecotoxicol Environ Saf 2021 Aug 21;219:112351. Epub 2021 May 21.

International Collaborative Laboratory for Air Pollution Health Effects and Intervention, School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province 453003, China. Electronic address:

Background: Exposure to ambient air-borne fine particulate matter (PM) increases respiratory morbidity and mortality. The mechanisms underlying PM-induced adverse effects remain unclear. This study aimed to uncover the molecular mechanisms of PM-induced lung toxicity using a mouse model.

Methods: Scanning electron microscopy and inductively coupled plasma mass spectrometry were used to examine and analyze PM morphology and element compositions, respectively. Twenty four male mice were randomly divided into three groups: control (PBS), PM (4.0 mg/kg b.w.), and PM + Z-YVAD-FMK. In the latter group, the pan-caspase inhibitor (Z-YVAD-FMK) was intraperitoneally injected into mice at a dose of 12.5 mg/kg body weight prior to intratracheal instillation of PM (4.0 mg/kg b.w.) every other day for a total of 3 times (n = 8 in each group). Bronchoalveolar lavage fluids (BALFs) were collected 24 h after the last instillation of PM. Levels of total proteins (TP), lactate dehydrogenase (LDH), IL-1β and IL-18 were analyzed for biomarkers of cell injury and inflammation. Additionally, histological alterations of lung tissues were assessed by hematoxylin-eosin staining. mRNA and protein expression of Caspase1, NLRP3 and GSDMD were examined by real-time fluorescent quantitative PCR and immunohistochemical staining.

Results: Exposure to PM increased levels of TP, LDH, IL-1β, IL-18 and inflammatory cell counts in lung. The mRNA and protein expression of Caspase1, NLRP3 and GSDMD were increased. Inhibition of the NALRP3/Caspase-1 signaling pathway ameliorated PM-induced lung injury and inflammation, partially through suppressing pyroptosis in lung.

Conclusion: PM exposure induces lung injury and inflammation, which is mediated by the NALRP3/Caspase-1 signaling pathway.
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http://dx.doi.org/10.1016/j.ecoenv.2021.112351DOI Listing
August 2021

Application of interval-valued Pythagorean fuzzy VIKOR approach for petroleum sludge treatment technology evaluation and selection.

Environ Sci Pollut Res Int 2021 May 10. Epub 2021 May 10.

School of Management Engineering, Shandong Jianzhu University, Jinan, 250000, China.

Petroleum sludge is produced during oilfield development and production and can negatively impact the production area and surrounding environment. With increasing attention to the environmental protection of oilfields, finding an energy-efficient, environmentally sound, cost-effective and socially acceptable sludge treatment method is crucial to the sustainable development of oil companies. However, there are several problems in the selection process: ① there is no effective index system for the evaluation of treatment technologies; ② there is data uncertainty and loss of information; ③ experts in the field often make one-sided decisions; and ④ the common decision models fail to balance the general effect and local dominance of a treatment technology. This study is innovative in the following aspects: ① a decision index system of petroleum sludge treatment technology is established; ② the interval-valued Pythagorean fuzzy set effectively managed data uncertainty and loss of information; ③ the redundancy-based expert weighting method is used to avoid one-sided decisions; and ④ using the basic ideas of the VIKOR model to balance the general effect and local dominance of a technology. Example verification proved the effectiveness of this method and a sensitivity analysis showed the results were reliable. Finally, this study compared the results obtained by three other similar methods, and comparative analysis demonstrated that this approach effectively evaluated and selected petroleum sludge treatment technologies. This study improves the rationality of petroleum sludge treatment technology selection and provides a necessary reference for the selection of treatment technology for other petroleum pollutants.
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http://dx.doi.org/10.1007/s11356-021-14225-6DOI Listing
May 2021

A correlation study of intestinal microflora and first-episode depression in Chinese patients and healthy volunteers.

Brain Behav 2021 May 7:e02036. Epub 2021 May 7.

HuiLongGuan Clinical Medical School, Beijing HuiLongGuan Hospital, Peking University, Beijing, China.

Objective: This research examines the intestinal-associated flora of patients with depression compared with healthy volunteers to identify the characteristics and differences of flora associated with depression. It provides a theoretical basis for the prevention and treatment of depression through intestinal micro-ecological regulation.

Methods: We recruited 30 patients with depression to participate in the patient group (PG), and 30 volunteers were recruited for the healthy control group (HG) from the Beijing Hui-long-guan Hospital. Thereafter, the 16S rRNA high-throughput sequencing method, using the Hamilton Depression Scale, was applied to analyze patient and healthy groups.

Results: PG and HG microflora were different regarding phylum, Family, Genus, and Order. The results showed that Barnesiella was the dominant flora in depression patients, while Lachnospiraceae and Alloprevotella were the dominant bacteria in healthy participants. The proportion of Betaproteobateria (Proteobacteria), Alcaligenaceae (proinflammatory), Peptostreptococcaceae, Catenibacterium, Romboutsia, Sutterella, and Burkholderiales in the anxiety-negative depressed group was significantly higher than in the anxiety-positive group; and the proportion of Anaerostipes (inflammation) and Faecalibacterium (anti-inflammatory) bacteria was significantly lower than that of patients with anxiety.

Conclusion: Results showed there were differences in intestinal micro-ecology between patients with depression and healthy volunteers. We found that the level of inflammation-related bacteria in anxiety-positive patients was lower than that in anxiety-negative patients. These results enrich the knowledge of relationships between depression and intestinal flora and provide a theoretical basis for probiotics to assist in the treatment of depression.
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http://dx.doi.org/10.1002/brb3.2036DOI Listing
May 2021

Transferrin receptor 1 ablation in satellite cells impedes skeletal muscle regeneration through activation of ferroptosis.

J Cachexia Sarcopenia Muscle 2021 May 6. Epub 2021 May 6.

Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, China.

Background: Satellite cells (SCs) are critical to skeletal muscle regeneration. Inactivation of SCs is linked to skeletal muscle loss. Transferrin receptor 1 (Tfr1) is associated with muscular dysfunction as muscle-specific deletion of Tfr1 results in growth retardation, metabolic disorder, and lethality, shedding light on the importance of Tfr1 in muscle physiology. However, its physiological function regarding skeletal muscle ageing and regeneration remains unexplored.

Methods: RNA sequencing is applied to skeletal muscles of different ages to identify Tfr1 associated to skeletal muscle ageing. Mice with conditional SC ablation of Tfr1 were generated. Between Tfr1 and Tfr1 (n = 6-8 mice per group), cardiotoxin was intramuscularly injected, and transverse abdominal muscle was dissected, weighted, and cryosectioned, followed by immunostaining, haematoxylin and eosin staining, and Masson staining. These phenotypical analyses were followed with functional analysis such as flow cytometry, tread mill, Prussian blue staining, and transmission electron microscopy to identify pathological pathways that contribute to regeneration defects.

Results: By comparing gene expression between young (2 weeks old, n = 3) and aged (80 weeks old, n = 3) mice among four types of muscles, we identified that Tfr1 expression is declined in muscles of aged mice (~80% reduction, P < 0.005), so as to its protein level in SCs of aged mice. From in vivo and ex vivo experiments, Tfr1 deletion in SCs results in an irreversible depletion of SCs (~60% reduction, P < 0.005) and cell-autonomous defect in SC proliferation and differentiation, leading to skeletal muscle regeneration impairment, followed by labile iron accumulation, lipogenesis, and decreased Gpx4 and Nrf2 protein levels leading to reactive oxygen species scavenger defects. These abnormal phenomena including iron accumulation, activation of unsaturated fatty acid biosynthesis, and lipid peroxidation are orchestrated with the occurrence of ferroptosis in skeletal muscle. Ferroptosis further exacerbates SC proliferation and skeletal muscle regeneration. Ferrostatin-1, a ferroptosis inhibitor, could not rescue ferroptosis. However, intramuscular administration of lentivirus-expressing Tfr1 could partially reduce labile iron accumulation, decrease lipogenesis, and promote skeletal muscle regeneration. Most importantly, declined Tfr1 but increased Slc39a14 protein level on cellular membrane contributes to labile iron accumulation in skeletal muscle of aged rodents (~80 weeks old), leading to activation of ferroptosis in aged skeletal muscle. This is inhibited by ferrostatin-1 to improve running time (P = 0.0257) and distance (P = 0.0248).

Conclusions: Satellite cell-specific deletion of Tfr1 impairs skeletal muscle regeneration with activation of ferroptosis. This phenomenon is recapitulated in skeletal muscle of aged rodents and human sarcopenia. Our study provides mechanistic information for developing novel therapeutic strategies against muscular ageing and diseases.
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http://dx.doi.org/10.1002/jcsm.12700DOI Listing
May 2021

Associations of short-term PM exposures with nasal oxidative stress, inflammation and lung function impairment and modification by GSTT1-null genotype: A panel study of the retired adults.

Environ Pollut 2021 Apr 24;285:117215. Epub 2021 Apr 24.

School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, 453003, China. Electronic address:

PM (particulate matter ≤2.5 μm in aerodynamic diameter) is a major urban air pollutant worldwide. Its effects on the respiratory system of the susceptible population have been less characterized. This study aimed to estimate the association of short-term PM exposure with respiratory outcomes of the retired adults, and to examine whether these associations were stronger among the subjects with GSTT-null genotype. 32 healthy subjects (55-77 years) were recruited for five follow-up examinations. Ambient concentrations of PM were monitored consecutively for 7 days prior to physical examination. Pulmonary outcomes including forced vital capacity (FVC), forced expiratory volume in 1 s (FEV), peak expiratory flow (PEF), and fractional exhaled nitric oxide (FeNO), and nasal fluid concentrations of 8-epi-prostaglandin F2 alpha (8-epi-PGF2α), tumor necrosis factor-α (TNF-α), interleukin-8 (IL-8) and IL-1β were measured. A linear mixed-effect model was introduced to evaluate the associations of PM concentrations with respiratory outcomes. Additionally, GSTT1 genotype-based stratification was performed to characterize modification on PM-related respiratory outcomes. We found that a 10 μg/m increase in PM was associated with decreases of 0.52 L (95% confidence interval [CI]: -1.04, -0.002), 0.64 L (95% CI: -1.13, -0.16), 0.1 (95% CI: -0.23, 0.04) and 2.87 L/s (95% CI: -5.09, -0.64) in FVC, FEV, FEV/FVC ratio and PEF at lag 2, respectively. Meanwhile, marked increases of 80.82% (95% CI: 5.13%, 156.50%) in IL-8, 77.14% (95% CI: 1.88%, 152.40%) in IL-1β and 67.87% (95% CI: 14.85%, 120.88%) in 8-epi-PGF2α were observed as PM concentration increased by 10 μg/m at lag 2. Notably, PM-associated decreases in FVC and PEF and increase in FeNO were stronger among the subjects with GSTT1-null genotype. In summary, short-term exposure to PM is associated with nasal inflammation, oxidative stress and lung function reduction in the retired subjects. Lung function reduction and inflammation are stronger among the subjects with GSTT1-null genotype.
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http://dx.doi.org/10.1016/j.envpol.2021.117215DOI Listing
April 2021

Fabrication of Polymer Composite Fibers Embedding Ultra-Long Micro/Nanowires.

Nanomaterials (Basel) 2021 Apr 7;11(4). Epub 2021 Apr 7.

Research Center of Laser Fusion, China Academy of Engineering Physics, Mianyang 621900, China.

Fabrication of polymer composite fibers embedding ultra-long micro/nanowires via an iterative melt co-drawing and bundling technique is reported in this study. The poly(methyl methacrylate) (PMMA) porous array templates were prepared with section-cutting the PMMA/polystyrene (PS) (shell/core) composite fibers and dissolution of inner PS. The results showed that the PS cores or pores in the PMMA matrix are regularly arranged with hexagonal, and their diameter and spacing exhibits a uniform distribution. Especially, the core diameter can be precisely controlled from millimeter-scale to nanometer-scale by multi-step melt co-drawing. Based on the PMMA porous array templates, the Cu nanowires were successfully prepared by electrochemical deposition. Moreover, to fabricate PMMA ultra-long micro/nanowires, the composite fibers with converse shell/core component of PS/PMMA were initially prepared, and then the outer PS was dissolved. The obtained PMMA micro/nanowires were characterized with smooth complete orientation structure. The study provides an experimental basis for fabricating such polymer composite fibers, micro/nano porous array templates, and micro/nanowires with precise and controllable manner to meet the real application requirements.
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http://dx.doi.org/10.3390/nano11040939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067675PMC
April 2021

Changes in ambient temperature increase hospital outpatient visits for allergic rhinitis in Xinxiang, China.

BMC Public Health 2021 03 27;21(1):600. Epub 2021 Mar 27.

Xinxiang Medical University, Xinxiang, 453003, China.

Background: The effect of ambient temperature on allergic rhinitis (AR) remains unclear. Accordingly, this study aimed to explore the relationship between ambient temperature and the risk of AR outpatients in Xinxiang, China.

Method: Daily data of outpatients for AR, meteorological conditions, and ambient air pollution in Xinxiang, China were collected from 2015 to 2018. The lag-exposure-response relationship between daily mean temperature and the number of hospital outpatient visits for AR was analyzed by distributed lag non-linear model (DLNM). Humidity, long-time trends, day of the week, public holidays, and air pollutants including sulfur dioxide (SO), and nitrogen dioxide (NO) were controlled as covariates simultaneously.

Results: A total of 14,965 AR outpatient records were collected. The relationship between ambient temperature and AR outpatients was generally M-shaped. There was a higher risk of AR outpatient when the temperature was 1.6-9.3 °C, at a lag of 0-7 days. Additionally, the positive association became significant when the temperature rose to 23.5-28.5 °C, at lag 0-3 days. The effects were strongest at the 25th (7 °C) percentile, at lag of 0-7 days (RR: 1.32, 95% confidence intervals (CI): 1.05-1.67), and at the 75th (25 °C) percentile at a lag of 0-3 days (RR: 1.15, 95% CI: 1.02-1.29), respectively. Furthermore, men were more sensitive to temperature changes than women, and the younger groups appeared to be more influenced.

Conclusions: Both mild cold and mild hot temperatures may significantly increase the risk of AR outpatients in Xinxiang, China. These findings could have important public health implications for the occurrence and prevention of AR.
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http://dx.doi.org/10.1186/s12889-021-10671-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004401PMC
March 2021

A modified rotating isosceles triangle osteotomy using a 3D-printed patient-specific guide for the treatment of cubitus varus in children: a case report and literature review.

Transl Pediatr 2021 Jan;10(1):215-222

Department of Orthopaedic Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

After corrective osteotomy of cubitus varus, the lateral condylar prominence is a common problem, which is believed to be due to the unequal relative cuts of the lateral base wedge osteotomy. Therefore, several related solutions have been proposed, such as dome osteotomy and step-cut osteotomies, which solve the above problems to a certain extent. This study aimed to: (I) use a modified corpectomy to correct the deformity, and (II) present a new corpectomy method that uses a 3D-printed specific guide with an isosceles triangle osteotomy. A 12-year-old male presented with a -30-degree cubitus varus deformity 5 years after a supracondylar fracture of the right humerus. The degree of correction was determined from the varus angle and the normal carrying angle on the normal side. A rotating isosceles triangle osteotomy was determined by using Mimics software. The accuracy of the osteotomy angle was confirmed by postoperative radiography. The mean postoperative carrying angle was found to be preserved at the 10-month follow-up, with no complications. A rotating isosceles triangle osteotomy with a 3D-printed patient-specific guide may be providing a relative accurate result. However, in order to obtain more rigorous research conclusions, more cases should be added to examine this methodology for bone deformity surgery in the near future.
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http://dx.doi.org/10.21037/tp-20-101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7882299PMC
January 2021

Upregulation of Long Non-Coding RNA GCC2-AS1 Facilitates Malignant Phenotypes and Correlated With Unfavorable Prognosis for Lung Adenocarcinoma.

Front Oncol 2020 26;10:628608. Epub 2021 Jan 26.

Department of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, China.

Background: The role played by long noncoding RNA GCC2-AS1 in primary malignant tumors remains poorly understood. This study aimed to determine the expression levels and evaluate the clinical significance and biological effects of GCC2-AS1 in lung adenocarcinoma (LUAD).

Methods: We used data obtained from tissue samples and the TCGA database to determine the levels of GCC2-AS1 expression LUAD patients, and the prognostic value of those levels. Functional experiments were performed to investigate the effect of GCC2-AS1 on LUAD cells. Genes that were differentially expressed in GCC2-AS1-low and -high groups were analyzed by an enrichment analysis. Additionally, a nomogram model was created and subgroup analyses were performed to further determine the prognostic value of GCC2-AS1 in LUAD.

Results: GCC2-AS1 expression was significantly upregulated in lung adenocarcinoma tissues as compared with normal tissues. Depletion of GCC2-AS1 inhibited the proliferation and invasion of LUAD cells . An elevated level of GCC2-AS1 was strongly correlated with shorter overall survival time and was identified as an independent prognostic marker for LUAD patients. Enrichment analyses conducted using GO, KEGG, and GSEA databases were performed to identify biological pathways that might involve GCC2-AS1. Several subgroups were found to have a significant prognostic value for patients in the GCC2-AS1-low and -high groups.

Conclusions: Our findings suggest that GCC2-AS1 can serve as a diagnostic and prognostic biomarker for LUAD patients.
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http://dx.doi.org/10.3389/fonc.2020.628608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870869PMC
January 2021

A graphical guide for constructing a finite element model of the cervical spine with digital orthopedic software.

Ann Transl Med 2021 Jan;9(2):169

Department of Orthopaedic Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Three-dimensional (3D) reconstruction and finite element analysis (FEA) have been extensively used to simulate cervical biomechanics. However, instructive articles providing full descriptions for operating Mimics software, Geomagic software, and FEA are rare in the literature. This omission has hindered research and development related to cervical spine biomechanics. Herein, we expound a detailed and easily understandable protocol for performing a digital biomechanics study which may facilitate a better understanding of the internal anatomy mechanics and the investigation of novel screw fixation techniques. We describe step-by-step instructions for use of Mimics and Geomagic software in FEA, along with a concise literature review. The key procedures of digital FEA stepwise instruction are presented, accompanied by a brief but complete report on the computed tomography (CT) imaging data for establishing the final finite element model. Previous publications regarding the commonly used software are also reviewed and discussed. Each piece of software performs a specific function for digital FEA establishment and each has its inherent shortcomings, making it is necessary to combine the software to leverage the advantages of each in order to best serve finite element research. For reasons of brevity, this study only provides an illustrative report on a small key part of finite element research in the cervical spine. These stepwise instructions can guide orthopedic researchers in conducting FEA studies in digital cervical biomechanics.
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http://dx.doi.org/10.21037/atm-20-2451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7867904PMC
January 2021

Short-term effect of NO on outpatient visits for dermatologic diseases in Xinxiang, China: a time-series study.

Environ Geochem Health 2021 Feb 9. Epub 2021 Feb 9.

Henan International Collaborative Laboratory for Health Effects and Intervention of Air Pollution, School of Public Health, Xinxiang Medical University, Xinxiang, 453003, Henan Province, China.

Objectives: As the largest organ of the human body, the skin is the major exposure route of NO. However, the evidence for a relationship between NO exposure and dermatologic diseases (DMs) is limited. This time-series study was conducted to assess the short-term effect of nitrogen dioxide (NO) exposure on DMs outpatient visits in Xinxiang, China.

Methods: Daily recordings of NO concentrations, meteorological data, and the outpatient visits data for DMs were collected in Xinxiang from January 1st, 2015, to December 31st, 2018. The analysis method used was based on the generalized additive model (GAM) with quasi-Poisson regression to investigate the relationship between NO exposure and DMs outpatient visits. Several covariates, such as long-term trends, seasonality, and weather conditions were controlled.

Results: A total of 164,270 DMs outpatients were recorded. A 10 μg/m increase in NO concentrations during the period was associated with a 1.86% increase in DMs outpatient visits (95% confidence intervals [Cl]: 1.06-2.66%). The effect was stronger (around 6 times) in the cool seasons than in warmer seasons and younger patients (< 15 years of age) appeared to be more vulnerable.

Conclusions: The findings of this study indicate that short-term exposure to NO increases the risk of DMs in Xinxiang, China, especially in the cool seasons. Policymakers should implement more stringent air quality standards to improve air quality.
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http://dx.doi.org/10.1007/s10653-021-00831-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7871127PMC
February 2021

Adjuvant chemoradiotherapy for patients with pathologic node-positive esophageal cancer following radical resection is associated with improved survival.

Ann Transl Med 2020 Dec;8(24):1633

Department of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, China.

Background: Depending on the pathological stage, patients with esophageal squamous cell carcinoma (ESCC) can experience poor prognosis after surgery. This study was designed to analyze the effect of various treatments on prognosis in pathologic node-positive esophageal cancer patients who undergo radical surgery.

Methods: We evaluated 210 pathologic stage IIb-IIIc patients (pT1-4aN + M0) who had undergone esophagectomy for thoracic ESCC from January 2013 to October 2015 at our institute. Surgery alone was applied in 65 patients, postoperative chemotherapy alone was applied in 112 patients, and postoperative adjuvant chemoradiotherapy was applied in 33 patients. Kaplan--Meier and Cox regression analysis were used to compare overall survival (OS) and disease-free survival (DFS). A nomogram was constructed to visualize the multivariate Cox regression analysis model.

Results: The median follow-up period was 49.4 months. The 3- and 5-year OS rates of the patients in the surgery group, postoperative chemotherapy group, postoperative chemoradiotherapy group were 55.4%, 61.6%, and 75.8%, and 30.1%, 44.0%, and 63.0% respectively. The 3- and 5-year DFS rates of the patients in the surgery group, postoperative chemotherapy group, postoperative chemoradiotherapy group were 44.6%, 52.7%, and 72.7%, and 20.0%, 24.1%, and 39.4%, respectively. Both the OS and DFS of the patients in the postoperative chemoradiotherapy group were better than those of the patients in the surgery and postoperative chemotherapy group. Among them, the OS of the postoperative radiotherapy group was longer than that of the surgery group (P=0.011) and the postoperative chemotherapy group (P=0.190), while the DFS of postoperative chemoradiotherapy group was longer than that of the surgery group and postoperative chemotherapy group, but the difference was not statistically significant (P>0.05).

Conclusions: This study showed that postoperative adjuvant chemoradiotherapy could improve 3-year OS and DFS compared with treatment using surgery alone or postoperative chemotherapy alone. However, an evaluation of long-term prognosis requires a longer follow-up.
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http://dx.doi.org/10.21037/atm-20-4893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812226PMC
December 2020

Annealing Condition Effects on the Structural Properties of FePt Nanoparticles Embedded in MgO via Pulsed Laser Deposition.

Nanomaterials (Basel) 2021 Jan 8;11(1). Epub 2021 Jan 8.

Science and Technology on Plasma Physics Laboratory, Research Center of Laser Fusion, CAEP, Mianyang 621900, China.

FePt nanoparticles (NPs) were embedded into a single-crystal MgO host by pulsed laser deposition (PLD). It was found that its phase, microstructures and physical properties were strongly dependent on annealing conditions. Annealing induced a remarkable morphology variation in order to decrease its total free energy. H/Ar (95% Ar + 5% H) significantly improved the 1 ordering of FePt NPs, making magnetic coercivity reach 37 KOe at room temperature. However, the samples annealing at H/Ar, O, and vacuum all showed the presence of iron oxide even with the coverage of MgO. MgO matrix could restrain the particles' coalescence effectively but can hardly avoid the oxidation of Fe since it is extremely sensitive to oxygen under the high-temperature annealing process. This study demonstrated that it is essential to anneal FePt in a high-purity reducing or ultra-high vacuum atmosphere in order to eliminate the influence of oxygen.
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http://dx.doi.org/10.3390/nano11010131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827411PMC
January 2021

[Short-term effect of gas explosion in real roadway environment on rats' brain neural behavior].

Wei Sheng Yan Jiu 2020 Nov;49(6):889-894

Institutes of Health Central Plains, Xinxiang Medical University, Xinxiang 453003, China.

Objective: To study the effect of gas explosion on brain nerve behavior of rats in real roadway environment.

Methods: Before the gas explosion, the real gas explosion roadway environment was simulated by using the roadway and explosion test system of gas explosion test in a large coal mine in Chongqing Research Institute of China Coal Science & Technology Group, and cage fixation and explosion parameter setting were carried out. That was to use the equivalent of 9. 0% gas containing mixed air and to install special cage in roadway gas detonation distance at point 40 m, 160 m and 240 m. The SPF grade healthy adult SD male rats anesthetized with chloral hydrate were placed among them, and the rats were placed in a position that could force the head. At the same time, the trunk part below the occipital foramen and the mouth and face above the line of inner canthus were fully protected, and the gas explosion experiment was carried out. A total of 40 rats were randomly divided into four groups according to their body weight: control group, burn-blast combined injuries group(40 m), proximal group(160 m) and distance group(240 m). Ten rats in each group were placed in cages at different distance points under anesthesia except the normal control group. The general physiological behavior of the rats was observed 2 h and 7 d after the explosion, and the neurobehavioral indexes of the rats were monitored by open field behavior experiment. Gross observation and pathological examination of brain tissue were performed 7 days later.

Results: The spirits of the rats in the 2 h exposure group after explosion were poor, and improved slightly after 7 d. The degree of surface burn was the most serious in group 40 m. The number of urination decreased while the number of feces increased(P>0. 05). At the end of the experiment, it was found that cerebral edema and hyperemia were obvious in rats. Compared with the normal control group, the brain weight of rats in each exposure group increased, and the difference was statistically significant(P<0. 05). Pathological observation showed that the brain tissues of rats in each exposed group showed irregular and disordered arrangement of nerve cells, interstitial edema, dense and deep staining of loose nuclear chromatin, formation of dense mass and other characteristics of apoptotic cells, as well as increased glia and aggregation of inflammatory cells. At 2 d and 7 h after the explosion, compared with the control group, the resting time of the neurobehavioral indicators of rats at different distance points was significantly prolonged(P<0. 01), while the number of standing times, movement time and movement distance were significantly reduced, and the difference was statistically significant(P<0. 01).

Conclusion: The gas explosion in real roadway environment can cause certain damage to the brain tissue of rats, and has obvious influence on its neural behavior.
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http://dx.doi.org/10.19813/j.cnki.weishengyanjiu.2020.06.003DOI Listing
November 2020

PM disrupts thyroid hormone homeostasis through activation of the hypothalamic-pituitary-thyroid (HPT) axis and induction of hepatic transthyretin in female rats 2.5.

Ecotoxicol Environ Saf 2021 Jan 3;208:111720. Epub 2020 Dec 3.

Experimental Teaching Center of Public Health and Preventive Medicine, School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, China 453003. Electronic address:

Fine particulate matter (PM), a ubiquitous environmental pollutant, has been indicated to affect thyroid hormone (TH) homeostasis in women, but the detailed mechanism behind this effect remains unclear. The objective of this study was to evaluate the roles of the hypothalamic-pituitary-thyroid (HPT) axis and hepatic transthyretin in the thyroid-disrupting effects of PM. Sprague Dawley rats were treated with PM (0, 15 and 30 mg/kg) by passive pulmonary inhalation for 49 days; and recovery experimental group rats were dosed with PM (30 mg/kg) for 35 days, and no treatment was done during the subsequent 14 days. PM was handled twice a day by passive pulmonary inhalation throughout the study. After treatment, pathological changes were analyzed by performing haemotoxylin and eosin staining, measuring levels of THs and urine iodine (UI) in serum, plasma, and urine samples using enzyme-linked immunoabsorbent assay, and expression of proteins in the hypothalamus, pituitary, thyroid, and liver tissues of rats were analyzed by immunohistochemistry and Western blotting. The levels of oxidative stress factors, such as reactive oxygen species (ROS), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (Gpx), and nuclear factor-kappa B (NF-κB) in female rats' plasma were also evaluated by ELISA. The results of these analyses revealed that PM treatment induced pathologic changes in rat thyroid and liver characterized by increased follicular cavity size and decreased amounts of follicular epithelial cells and fat vacuoles, respectively. Serum levels of triiodothyronine, thyroxine, and thyroid stimulating hormone were significantly decreased, plasma NF-κB level was increased and plasma redox state was unbalanced (enhanced ROS, MDA and Gpx levels; reduced SOD activities) in female rats treated with PM (P < 0.05). PM treatment suppressed the biosynthesis and biotransformation of THs by increasing sodium iodide symporter, thyroid transcription factor 1, thyroid transcription factor 2, and paired box 8 protein expression levels (P < 0.05). Additionally, thyroid stimulating hormone receptor and thyroid peroxidase levels were significantly decreased (P < 0.05). Both thyrotropin releasing hormone receptor and thyroid stimulating hormone beta levels were enhanced (P < 0.05). Moreover, transport of THs was inhibited due to reduced protein expression of hepatic transthyretin upon treatment with PM. In summary, PM treatment could perturb TH homeostasis by affecting TH biosynthesis, biotransformation, and transport, affecting TH receptor levels, and inducing oxidative stress and inflammatory responses. Activation of the HPT axis and altered hepatic transthyretin levels therefore appear to play a crucial role in PM-induced thyroid dysfunction.
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http://dx.doi.org/10.1016/j.ecoenv.2020.111720DOI Listing
January 2021

MUC 15 Promotes Osteosarcoma Cell Proliferation, Migration and Invasion through Livin, MMP-2/MMP-9 and Wnt/β-Catenin Signal Pathway.

J Cancer 2021 1;12(2):467-473. Epub 2021 Jan 1.

Danyang People's Hospital of Jiangsu Province, Danyang, Jiangsu 212300, China.

To investigate the high expression of MUC15 in promoting proliferation, migration and invasion in osteosarcoma (OS) cell and its potential mechanism. The expressions of MUC15 in OS patients were analyzed from GEO Datasets, tumor cell lines and clinical samples. The roles of MUC15 in OS were explored by CCK-8, flow cytometry, transwell and western blot assay, respectively. MUC15 was highly expressed in osteosarcoma, and there was a significant negative correlation between MUC15 and the prognosis. Knockdown of MUC15 in HOS and U-2OS could promote tumor cell apoptosis, down-regulate the expression of MMP2/9, reduce the epithelial interstitial transition and silence the Wnt/b-Catenin signal pathway. The high-expression of MUC15 promotes the proliferation, migration and invasion of osteosarcoma through anti-apoptosis, increasing the invasive ability by epithelial interstitial transition, and activating the Wnt/b-Catenin signal pathway.
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http://dx.doi.org/10.7150/jca.49641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7739004PMC
January 2021

Overexpression of the Lias gene attenuates hepatic steatosis in Leprdb/db mice.

J Endocrinol 2021 Feb;248(2):119-131

School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, China.

Oxidative stress is proposed to be involved in nonalcoholic fatty liver disease (NAFLD). However, antioxidant therapy results in controversial outcomes. Therefore, we generated a new antioxidant/NAFLD mouse model, LiasHigh/HighLeprdb/db mice, by crossbreeding Leprdb/db mice, an obesity mouse model, with LiasHigh/High mice, generated by overexpression of lipoic acid synthase gene (Lias) and having increased endogenous antioxidant capacity, to investigate whether the new model could block the development of NAFLD. We have systemically characterized the novel model based on the main features of human NAFLD, determined the impact of enhanced endogenous antioxidant capacity on the retardation of NAFLD and elucidated the underlying mechanisms using various biological and pathological methods. We found that LiasHigh/HighLeprdb/db mice ameliorated many pathological changes of NAFLD compared with the control. In particular, LiasHigh/HighLeprdb/db mice displayed the improved liver mitochondrial function, reflecting the decline of mitochondrial microvesicular steatosis, and reduced oxidative stress, which mainly contributes to the alleviation of pathologic alterations of the NAFLD progression. Our new model shows that mitochondrial dysfunction is a major pathogenesis for liver steatosis. Overexpression of Lias gene effectively reduces oxidative stress and protects mitochondria, and consequently attenuates NAFLD/NASH.
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http://dx.doi.org/10.1530/JOE-19-0606DOI Listing
February 2021

M2 Macrophage-Derived Exosomes Promote Angiogenesis and Growth of Pancreatic Ductal Adenocarcinoma by Targeting E2F2.

Mol Ther 2021 03 20;29(3):1226-1238. Epub 2020 Nov 20.

Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, People's Republic of China. Electronic address:

Pancreatic ductal adenocarcinoma (PDAC), one of the most aggressive tumors all over the world, has a generally poor prognosis, and its progression is positively correlated with the density of blood vessels. Recently, tumor-associated macrophages (TAMs) were proven to be beneficial for angiogenesis, but their mechanism of action remains unclear. Our study indicated that M2 macrophages were positively correlated with the microvessel density (MVD) of PDAC tissues, and M2 macrophage-derived exosomes (MDEs) could promote the angiogenesis of mouse aortic endothelial cells (MAECs) in vitro. At the same time, the M2 MDEs could also promote the growth of subcutaneous tumors and increase the vascular density of mice. Moreover, we also found that miR-155-5p and miR-221-5p levels in the M2 MDEs were higher than those in M0 MDEs, and they could be transferred into MAECs, as demonstrated by RNA sequencing (RNA-seq) and qPCR analysis. Our data confirmed the interaction between TAMs and the angiogenesis of PDAC by exosomes. Additionally, targeting the exosomal miRNAs derived from TAMs might provide diagnostic and therapeutic strategies for PDAC.
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http://dx.doi.org/10.1016/j.ymthe.2020.11.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934635PMC
March 2021

A pathological complete response to neoadjuvant chemotherapy and immunotherapy in a non-small cell lung cancer patient.

Transl Lung Cancer Res 2020 Oct;9(5):2157-2160

Department of Thoracic Surgery, Fujian Medical Union Hospital, Fuzhou, China.

Lung cancer is the leading cause of cancer-related mortality worldwide. Patients with locally advanced non-small cell lung cancer (NSCLC) have lower overall survival. Studies have shown that some patients with unresectable stage III NSCLC develop disease progression after initial chemoradiotherapy, and new treatment is needed to improve the prognosis of these patients. The rapid development of therapy has greatly changed and continued to renew the treatment strategy of advanced NSCLC. However, the clinical treatment for patients with the wild-type gene remains problematic, and chemotherapy with platinum are not yet considered satisfactory. Herein, we are reporting a case of a patient with wild-type gene mutation locally advanced NSCLC who was treated with neoadjuvant therapy by using combined targeted anti-PD-1 immunotherapy and chemotherapy. The percentage of tumor cells with membranous PD-L1 staining (tumor proportion score) was 90% or greater. After receiving all three cycles of treatment, the patient underwent video-assisted right upper lung lobectomy and wedge resection plus radical mediastinal lymph node dissection. Pathological section samples showed a pathological complete response. This experience has led us to believe that the subgroup of patients with unresectable advanced NSCLC may benefit from this strategy and may have an opportunity for radical surgery.
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http://dx.doi.org/10.21037/tlcr-20-770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7653127PMC
October 2020

Acute effects of ambient air pollution on outpatients with chronic rhinitis in Xinxiang, China.

Environ Sci Pollut Res Int 2021 Feb 6;28(8):9889-9897. Epub 2020 Nov 6.

Henan International Collaborative Laboratory for Health Effects and Intervention of Air Pollution, School of Public Health, Xinxiang Medical University, Xinxiang, 453003, Henan Province, China.

Air pollution exposure leads to increased mortality and morbidity rates of respiratory diseases. Most of the evidence was founded on acute diseases such as acute lower respiratory diseases. However, limited studies have been conducted to evaluate the effects of air pollution on chronic respiratory diseases. This time-series study was conducted to examine the acute effects of 6 criteria ambient air pollutants on hospital outpatients with chronic rhinitis (CR) in Xinxiang, China. We retrieved 223,826 outpatient records of patients with respiratory diseases, of which 62,901 were those of patients with CR. Results showed that the current 10-μg/m increase in fine particulate matter (PM), inhalable particulate matter (PM), sulfur dioxide (SO), nitrogen dioxide (NO), and carbon monoxide (CO) corresponds to 0.67% (95% confidence interval [CI]: 0.15-1.18%), 0.58% (95% CI: 0.24-0.92%), 1.89% (95% CI: 0.52-3.27%), 3.01% (95% CI: 1.66-4.35%), and 0.06% (95% CI: 0.03-0.10%) increments in outpatients with CR, respectively. In addition, the effects in the male were stronger than those in the female. Higher effect estimates were observed in the old (≥ 65 years of age) and younger (< 15 years of age) groups. Our study confirmed the association between air pollution and outpatients with CR in Xinxiang, China. More stringent air pollution control measures must be implemented.
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http://dx.doi.org/10.1007/s11356-020-11534-0DOI Listing
February 2021

Enhanced visible light photoelectrocatalytic degradation of tetracycline hydrochloride by I and P co-doped TiO photoelectrode.

J Hazard Mater 2021 03 26;406:124309. Epub 2020 Oct 26.

School of Public Health, Xinxiang Medical University, Xinxiang 453003, China.

Elimination of antibiotics such as tetracycline hydrochloride (TC) from wastewater is of great significance, but still faces challenges. Herein, for the first time, I and P co-doped TiO catalysts were prepared via a hydrolysis method. We also reported a simple method to prepare I and P co-doped TiO photoelectrodes, which exhibited preeminent photoelectrocatalytic (PEC) performance for the decomposition of TC. The synergistic effect of I and P co-doping could significantly improve the charge separation rate and enhance the light absorption capacity of TiO, leading to an enhancement of PEC activity. The main factors affecting the PEC performance were investigated, and the highest degradation rate constant (4.20 × 10 min) was achieved when the doping content of P was 4 at% (ITP-4 photoelectrode) at pH 11.02 under visible light. The Langmuir-Hinshelwood kinetic model and active species trapping experiments were selected to investigate the degradation mechanism of TC. The results suggest that the hydroxyl radicals and photogenerated holes were the main active species that were responsible for the decomposition of TC. Moreover, the degradation pathways of TC based on the intermediates also demonstrated that the hydroxyl radicals and holes showed a principal role in degrading TC.
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http://dx.doi.org/10.1016/j.jhazmat.2020.124309DOI Listing
March 2021

Sorption mechanisms of lead on soil-derived black carbon formed under varying cultivation systems.

Chemosphere 2020 Dec 3;261:128220. Epub 2020 Sep 3.

College of Tropical Crops, Hainan University, Haikou, 570228, China. Electronic address:

The knowledge about lead (Pb) sorption on soil-derived black carbons (SBCs) under different cultivation intensities of soils is limited. In this study, chemical and spectroscopic methods were applied to investigate the Pb sorption mechanisms on SBCs in soils from a forest land, a rubber plantation area, and a vegetable farm with none, less and highly intensive cultivation, respectively, that are located in the Hainan Island of China. Results showed that the specific surface area and cation exchange capacity of the SBCs from the less and highly intensive cultivation soils were 4.5- and 2.7-fold, and 1.3- and 1.8-fold higher compared to that of SBC from the no-cultivation soil, which subsequently enhanced the Pb sorption capacities of SBCs in iron exchange fraction. Ion exchange and hydrogen bonded Pb fractions together accounted for about 80% of total Pb sorbed on all SBCs at an externally added 1000 mg L Pb solution concentration. The OC-O groups also played key roles in Pb sorption by forming complexes of OC-O-Pb-O and/or OC-O-Pb. Overall, SBCs in soils under all studied cultivation intensities showed high potential to sorb Pb (with the maximum absorbed Pb amount of 46.0-91.3 mg g), and increased Pb sorption capacities of the studied soils by 18.7-21.1 mg kg in the stable fraction (complexation). Therefore, SBC might be a potential environment-friendly material to enhance the Pb immobilization capacity of soil.
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http://dx.doi.org/10.1016/j.chemosphere.2020.128220DOI Listing
December 2020

A preliminary multicenter evaluation of endoscopic sublay repair for ventral hernia from China.

BMC Surg 2020 Oct 12;20(1):233. Epub 2020 Oct 12.

Department of Hernia and Abdominal Wall Surgery, East hospital affiliated to Tongji University, 150 Jimo Rd, Shanghai, 200120, China.

Background: For ventral hernia, endoscopic sublay repair (ESR) may overcome the disadvantages of open sublay and laparoscopic intraperitoneal onlay mesh repair. This retrospective study presents the preliminary multicenter results of ESR from China. The feasibility, safety, and effectiveness of ESR were evaluated; its surgical points and indications were summarized.

Methods: The study reviewed 156 ventral hernia patients planned to perform with ESR in ten hospitals between March 2016 and July 2019. Patient demographics, hernia characteristics, operative variables, and surgical results were recorded and analyzed.

Results: ESR was performed successfully in 153 patients, 135 with totally extraperitoneal sublay (TES) and 18 with transabdominal sublay (TAS). In 19 patients, TES was performed with the total visceral sac separation (TVS) technique, in which the space separation is carried out along the peritoneum, avoiding damage to the aponeurotic structure. Endoscopic transversus abdominis release (eTAR) was required in 17.0% of patients, and only 18.3% of patients required permanent mesh fixation. The median operative time was 135 min. Most patients had mild pain and resume eating soon after operation. No severe intraoperative complications occurred. Bleeding in the extraperitoneal space occurred in two patients and was stopped by nonsurgical treatment. Seroma and chronic pain were observed in 5.23 and 3.07% of patients. One recurrence occurred after TAS repair for an umbilical hernia.

Conclusion: ESR is feasible, safe, and effective for treating ventral hernias when surgeons get the relevant surgical skills, such as the technique of "partition breaking," TVS, and eTAR. Small-to-medium ventral hernias are the major indications.
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http://dx.doi.org/10.1186/s12893-020-00888-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7552516PMC
October 2020

Use of meteorological parameters for forecasting scarlet fever morbidity in Tianjin, Northern China.

Environ Sci Pollut Res Int 2021 Feb 7;28(6):7281-7294. Epub 2020 Oct 7.

Department of Epidemiology and Health Statistics, School of Public Health, Xinxiang Medical University, No. 601 Jinsui road, Hongqi District, Xinxiang City, 453003, Henan Province, People's Republic of China.

The scarlet fever incidence has increased drastically in recent years in China. However, the long-term relationship between climate variation and scarlet fever remains contradictory, and an early detection system is lacking. In this study, we aim to explore the potential long-term effects of variations in monthly climatic parameters on scarlet fever and to develop an early scarlet-fever detection tool. Data comprising monthly scarlet fever cases and monthly average climatic variables from 2004 to 2017 were retrieved from the Notifiable Infectious Disease Surveillance System and National Meteorological Science Center, respectively. We used a negative binomial multivariable regression to assess the long-term impacts of weather parameters on scarlet fever and then built a novel forecasting technique by integrating an autoregressive distributed lag (ARDL) method with a nonlinear autoregressive neural network (NARNN) based on the significant meteorological drivers. Scarlet fever was a seasonal disease that predominantly peaked in spring and winter. The regression results indicated that a 1 °C increment in the monthly average temperature and a 1-h increment in the monthly aggregate sunshine hours were associated with 17.578% (95% CI 7.674 to 28.393%) and 0.529% (95% CI 0.035 to 1.025%) increases in scarlet fever cases, respectively; a 1-hPa increase in the average atmospheric pressure at a 1-month lag was associated with 12.996% (95% CI 9.972 to 15.919%) decrements in scarlet fever cases. Based on the model evaluation criteria, the best-performing basic and combined approaches were ARDL(1,0,0,1) and ARDL(1,0,0,1)-NARNN(5, 22), respectively, and this hybrid approach comprised smaller performance measures in both the training and testing stages than those of the basic model. Climate variability has a significant long-term influence on scarlet fever. The ARDL-NARNN technique with the incorporation of meteorological drivers can be used to forecast the future epidemic trends of scarlet fever. These findings may be of great help for the prevention and control of scarlet fever.
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http://dx.doi.org/10.1007/s11356-020-11072-9DOI Listing
February 2021

Roles and mechanisms of renalase in cardiovascular disease: A promising therapeutic target.

Biomed Pharmacother 2020 Nov 9;131:110712. Epub 2020 Sep 9.

Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Institute of Traditional Chinese Medicine, Beijing, 100010, China. Electronic address:

Cardiovascular disease (CVD) is prevalent worldwide and remains a leading cause of death. Although substantial progress has been made in the diagnosis and treatment of CVD, the prognosis remains unsatisfactory. Renalase is a newly discovered cytokine that is synthesized by the kidney and then secreted into blood. Numerous studies have suggested the efficacy of renalase in treating CVD by metabolizing catecholamines in the circulatory system. As a new biomarker of heart disease, renalase is normally recognized as a signalling molecule that activates cytoprotective intracellular signals to lower blood pressure, protect ischaemic heart muscle and promote atherosclerotic plaque stability in CVD, which subsequently improves cardiac function. Due to its important regulatory role in the circulatory system, renalase has gradually become a potential target in the treatment of CVD. This review summarizes the structure, mechanism and function of renalase in CVD, thereby providing preclinical evidence for alternative approaches and new prospects in the development of renalase-related drugs against CVD.
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http://dx.doi.org/10.1016/j.biopha.2020.110712DOI Listing
November 2020

Modern urbanization has reshaped the bacterial microbiome profiles of house dust in domestic environments.

World Allergy Organ J 2020 Aug 20;13(8):100452. Epub 2020 Aug 20.

School of Public Health, Curtin University, Perth, WA, Australia.

Background: The prevalence of allergy and other common chronic diseases is higher in developed than developing countries, and higher in urban than rural regions. Urbanization through its modification of environmental microbiomes may play a predominant role in the development of these conditions. However, no studies have been conducted to compare the microbiome in house dust among areas with different urbanization levels.

Methods: House dust from Xinxiang rural area (XR, n = 74), Xinxiang urban area (XU, n = 33), and Zhengzhou urban area (ZU, n = 32) in central China, and from Australia (AU, n = 58 [with pets AUP, n = 15, without pets AUNP, n = 43]) were collected during a summer season in China and Australia. High-throughput sequencing of 16S rDNA was employed to profile house dust bacterial communities.

Results: Settled dust collected in China was dominant with 2 bacterial phyla: Proteobacteria and Actinobacteria, while floor dust collected in Australia had a higher proportion of phylum Proteobacteria, Firmicutes, and Actinobacteria. XR dust samples presented higher bacterial richness and diversity compared with XU or ZU samples. Urbanization level (r = 0.741  < 0.001) had a significant correlation with the distribution of house dust bacterial community. At the genus level, there was a positive correlation (r coefficient > 0.5) between urbanization level and bacterial genera and a negative correlation (r coefficient < -0.5) with .

Conclusion: There was a significant difference in house dust microbiota among different urbanization areas. The areas with a lower urbanization level presented higher dust-borne bacterial richness and diversity. Modern urbanization has a significant influence on the bacterial microbiome profiles of indoor dust.
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http://dx.doi.org/10.1016/j.waojou.2020.100452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7451671PMC
August 2020

Curettage through a wide cortical window for treatment of a primary aneurysmal bone cyst of the patella.

J Int Med Res 2020 Aug;48(8):300060520947910

Department of Gastroenterology, Suzhou Ninth People's Hospital (Affiliated Wujiang Hospital of Nantong University), Suzhou, China.

A 27-year-old man presented with intermittent right knee pain for 1 year with no previous trauma. Physical examination revealed only tenderness over the patella. Typical fluid-fluid levels were visible on magnetic resonance imaging (MRI), which highly suggested aneurysmal bone cyst (ABC) of the patella. After removal of a large window of thin cortical bone, curettage and bone grafting followed by cerclage wiring was performed. Histology confirmed the initial diagnosis of primary ABC of the patella. At the final follow-up visit at 71 months after surgery, the patient had normal joint activity with no pain or evidence of recurrence. Previous publications indicated patellectomy in the initial series, but curettage and bone grafting have more recently provided excellent results and good graft incorporation in most cases, even for aggressive lesions. In our patient, thorough curettage and bone grafting through a wide cortical window followed by cerclage wiring fixation and figure-eight sutures was a successful treatment option for primary ABC of the patella without articular disruption.
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http://dx.doi.org/10.1177/0300060520947910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7513413PMC
August 2020

Acute effect of ambient air pollution on hospital outpatient cases of chronic sinusitis in Xinxiang, China.

Ecotoxicol Environ Saf 2020 Oct 7;202:110923. Epub 2020 Jul 7.

Henan International Collaborative Laboratory for Health Effects and Intervention of Air Pollution, School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, 453003, China. Electronic address:

Many studies have reported that exposure to ambient air pollution has adverse effects on health. However, there are little researches to explore the relationship between ambient air pollution and chronic sinusitis (CS). From January 1 2015 to December 31 2018, a time-series study were carried out to investigate the acute adverse roles of six criteria ambient air pollutants (fine particulate matter [PM], inhalable particulate matter [PM], nitrogen dioxide [NO], sulfur dioxide [SO], ozone [O], and carbon monoxide [CO]) in hospital outpatients with CS in Xinxiang, China. Then, an over-dispersed Poisson generalized additive model was utilized to analyzed the relationships. In total, 183,943 hospital outpatient cases of CS were identified during the study period. We found that a 10 μg/m increase in PM, PM, SO, NO, and CO corresponded to 0.48% (95% confidence interval: 0.22-0.74%), 0.33% (0.16-0.50%), 0.88% (0.13-1.62%), 1.98% (1.31-2.64%), and 0.05% (0.03-0.07%) increments, respectively, in CS outpatients on the current day. The young group (<15 years of age) was more susceptible than the adult or elderly groups. These results suggested that outdoor air pollutants might increase CS outpatient, especially among youth in Xinxiang. Precautions and protective measures should be strengthened to reduce the air pollution level in the future.
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http://dx.doi.org/10.1016/j.ecoenv.2020.110923DOI Listing
October 2020