Publications by authors named "Weidong Shi"

97 Publications

Oxygen-doped hollow, porous NiCoP nanocages derived from Ni-Co prussian blue analogs for oxygen evolution.

Chem Commun (Camb) 2021 Jul 27. Epub 2021 Jul 27.

School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China.

An oxygen-doped, hollow, porous NiCoP nanocage (O-NiCoP Cages) electrocatalyst was synthesized derived from Ni-Co Prussian blue analogs. O-NiCoP Cages exhibited an overpotential of 310 mV at 10 mA cm-2 and a Tafel slope of 84 mV dec-1, significantly higher than that of undoped NiCoP nanocages, and also better than that of RuO2 and several reported phosphide electrocatalysts. This work provides a new strategy for the design of highly efficient oxygen evolution reaction (OER) electrocatalysts based on hollow, nanostructured and heteroatom-doped metal phosphides.
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http://dx.doi.org/10.1039/d1cc00535aDOI Listing
July 2021

Discharge-Induced Enhancement of the Oxygen Evolution Reaction.

Angew Chem Int Ed Engl 2021 Jul 12. Epub 2021 Jul 12.

Jiangsu University, School of Chemistry and Chemical Engineering, Xuefu Road 301, 212013, Zhenjiang, CHINA.

The fundamental understanding of the surface reconstruction induced by the applied potential is of great significance for enhancing the oxygen evolution reaction (OER). Here, we show that a previously overlooked discharge current in the low applied potential region also leads to in situ electrochemical activation of a nitrogen-doped nickel oxyhydroxide surface. We exploit the fact that doping of heteroatoms weakens the surface structure, and hence, a weak discharge current originating from the capacitive nature of nickel oxyhydroxide has a strong structure-reforming ability to promote the formation of nitrogen and oxygen vacancies. The current density at 1.4 V (vs. Hg/HgO) can dramatically increase by as much as 31.3% after discharge in the low applied potential region. This work provides insight into in situ enhancement of the OER and suggests that the low applied potential region must be a primary consideration in evaluating the origin of the activity of electrocatalysts.
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http://dx.doi.org/10.1002/anie.202108770DOI Listing
July 2021

ZIF-8 derived ZnO/TiO heterostructure with rich oxygen vacancies for promoting photoelectrochemical water splitting.

J Colloid Interface Sci 2021 Jun 17;603:120-130. Epub 2021 Jun 17.

Institute of Green Chemistry and Chemical Technology, School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, PR China. Electronic address:

Due to the serious recombination of electron-hole and weak photoresponse ability, achieving highly efficient photoelectrochemical (PEC) water splitting activity for TiO photoelectrode has become a key issue. In this paper, we reported a new method for preparing ZnO/TiO photoelectrodes by electrostatic adsorption from zeolitic imidazolate framework-8 (ZIF-8) as the precursor. ZIF-8 was combined with TiO nanorods (NRs) through electrostatic interaction and then calcined to obtain ZnO/TiO heterojunction photoelectrodes with abundant oxygen vacancies (O). The introduced ZnO with O provides a large number of active sites which enhanced the electrical conductivity and charges separation of ZnO/TiO photoelectrode. The optimal photocurrent density of ZnO/TiO photoelectrodes at 1.23 V versus (vs.) reversible hydrogen electrode (RHE) under illumination (100 mW/cm) has reached 1.76 mA/cm, almost 2.75 times that of the pure TiO. Meanwhile, the incident photon-to-electron conversion efficiency (IPCE) of the best photoelectrode has increased to 58.2% at 390 nm, the charge injection (η) and separation (η) efficiency have reached to 93.53% and 51.62% (1.23 V vs. RHE), respectively.
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http://dx.doi.org/10.1016/j.jcis.2021.06.087DOI Listing
June 2021

Carbon nanotubes interpenetrating MOFs-derived Co-Ni-S composite spheres with interconnected architecture for high performance hybrid supercapacitor.

J Colloid Interface Sci 2021 Jun 6;602:627-635. Epub 2021 Jun 6.

School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, PR China. Electronic address:

Recently, carbon nanotubes (CNT)-based interconnected architectures exhibit promising prospects in supercapacitors due to their flexibility and high electrical conductivity. Herein, a three-dimensional (3D) interconnected network structure combined with conductive carbon nanotubes interpenetrating MOFs-derived Co-Ni-S composite spheres (Co-Ni-S/CNTs) was synthesized. Such 3D interconnected architecture significantly leads to a favorable electronic structure, fast charge-transfer capacity, and more pseudocapacitive. The Co-Ni-S/CNTs-based hybrid electrode exhibits an extraordinary specific capacitance of 540.6C g at 1 A g and competitive rate performance (capacity retention rate of 69.9% when the current density increases to 10 times). Subsequently, a hybrid supercapacitor is assembled using Co-Ni-S/CNTs as the positive electrode and commercial activated carbon as negative electrode. The device delivers a high energy density of 63.5 W h kg at 800 W kg and keeps 83.0% initial capacitance retention after 10,000 cycles. The encouraging performances demonstrate the significant contribution of the 3D interconnected architecture for the future energy storage.
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http://dx.doi.org/10.1016/j.jcis.2021.06.027DOI Listing
June 2021

Phosphorus doped nickel selenide for full device water splitting.

J Colloid Interface Sci 2021 Jun 10;602:115-122. Epub 2021 Jun 10.

School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, China. Electronic address:

The lack of high active and stable electrocatalysts has impeded the development of electrochemical water splitting device, which is promising technique for renewable energy conversion system. Here, we report a one-step protocol to synthesize P doped NiSe (P-NiSe) by selenylation process derived from nickel foam with assistant of NaHPO and Se powder. The P-NiSe could be directly used as working electrode and shows the superior electrochemical activity, offering current density of 10 mA cm with overpotential of 270 mV for OER and 71 mV for HER. The enhanced electrochemical activity can be ascribed to the P atom doping. The P atom doping leads to the high valence state of Ni active sites, which have high catalytic ability towards OER. Moreover, the P doping makes the d-band center of Ni atoms in P-NiSe move close to Fermi level, facilitating the HER kinetics with respect to proton adsorption and hydrogen desorption. When employed P-NiSe as both anodic and cathodic electrode in alkaline water electrolyzer, a current density of 10 mA cm can be achieved at 1.58 V. Our work highlights the importance of P doping in determining the surface electron configuration for full device water splitting and the facile synthesis protocol would be promising for realistic applications.
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http://dx.doi.org/10.1016/j.jcis.2021.06.013DOI Listing
June 2021

High-performance supercapacitor based on highly active P-doped one-dimension/two-dimension hierarchical NiCoO/NiMoO for efficient energy storage.

J Colloid Interface Sci 2021 May 18;601:793-802. Epub 2021 May 18.

School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, PR China. Electronic address:

Multi-dimensional metal oxides have become a promising alternative electrode material for supercapacitors due to their inherent large surface area. Herein, P-doped NiCoO/NiMoO multi-dimensional nanostructures are synthesized on carbon clothes (CC) with a continuous multistep strategy. Especially, P has the best synergistic effect with transition metals, such as optimal deprotonation energy and OH adsorption energy, which can further enhance electrochemical reaction activity. For the above reasons, the P-NiCoO/[email protected] electrode exhibits an ultra-high specific capacitance of 2334.0 F g at 1 A g. After 1500 cycles at a current density of 10 A g, its specific capacity still maintains 93.7%. Besides, a P-NiCoO/[email protected]//activated carbon device (hybrid supercapacitor or device) was also prepared with a maximum energy density of 45.1 Wh kg at a power density of 800 W kg. In particular, the capacity retention rate is still 89.97% after 8000 cycles due to its excellent structural stability. Our work demonstrates the vast potential of multi-dimensional metal oxides in energy storage.
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http://dx.doi.org/10.1016/j.jcis.2021.05.095DOI Listing
May 2021

Melatonin alleviates titanium nanoparticles induced osteolysis via activation of butyrate/GPR109A signaling pathway.

J Nanobiotechnology 2021 Jun 6;19(1):170. Epub 2021 Jun 6.

Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, No. 188 Shizi Street, Suzhou, 215006, Jiangsu, China.

Background: Inflammatory osteolysis after total joint replacement (TJR) may cause implant failure, periprosthetic fractures, and be a severe threat to global public health. Our previous studies demonstrated that melatonin had a therapeutic effect on wear-particles induced osteolysis. Gut microbiota is closely related to bone homeostasis, and has been proven to be affected by melatonin. However, whether melatonin could play its anti-osteolysis effects through reprogramming gut microbiota remains elusive.

Results: Here, we demonstrated that melatonin could alleviate Ti-particles induced osteolysis, while this therapeutic effect was blocked by antibiotic cocktail treatment. Interestingly, transplantation of fecal microbiota from mice treated with melatonin reappeared the same beneficial effect. Analysis of the 16S rRNA revealed that melatonin could reverse dysbacteriosis triggered by osteolysis, and elevate the relative abundance of some short chain fatty acid (SCFA) producing bacteria. Moreover, butyrate was enriched by exogenous melatonin administration, while acetate and propionate did not show an evident difference. This was consistent with the results of the metagenomic approach (PICRUSt2) analysis, which revealed a general increase in the synthetic enzymes of butyrate. More importantly, direct supplementation of butyrate could also recapitulate the anti-osteolysis effect of melatonin. Further analysis identified that butyrate alleviated osteolysis via activating its receptor GPR109A, and thus to suppress the activation of NLRP3 inflammasome triggered by Ti-particles.

Conclusions: Taken together, our results suggested that the benefits of melatonin mainly depend on the ability of modulating gut microbiota and regulating butyrate production.
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http://dx.doi.org/10.1186/s12951-021-00915-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8182936PMC
June 2021

Oxygen vacancy engineering of BiOBr/HNbO Z-scheme hybrid photocatalyst for boosting photocatalytic conversion of CO.

J Colloid Interface Sci 2021 Oct 17;599:245-254. Epub 2021 Apr 17.

School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China.

Photo-chemical conversion of CO into solar fuels by photocatalysts is a promising and sustainable strategy in response to the ever-increasing environmental problems and imminent energy crisis. However, it is unavoidably impeded by the insufficient active site, undesirable inert charge transfer and fast recombination of photogenerated charge carriers on semiconductor photocatalysts. In this work, all these challenges are overcome by construction of a novel defect-engineered Z-scheme hybrid photocatalyst, which is comprised of three-dimensional (3D) BiOBr nanoflowers assembled by nanosheets with abundant oxygen vacancies (BiOBr-V) and two-dimensional (2D) HNbO nanosheets (HNbO NS). The special 3D-2D architecture structure is beneficial to preventing photocatalyst stacking and providing more active sites, and the introduced oxygen vacancies not only broaden the light absorption range but also enhance the electrical conductivity. More importantly, the constructed Z-scheme photocatalytic system could accelerate the charge carriers transfer and separation. As a result, the optimal BiOBr-V/HNbO NS (50%-BiOBr-V/HNbO NS) shows a high CO production yield of 164.6 μmol·g with the selectivity achieves to 98.7% in a mild gas-solid system using water as electron donors. Moreover, the BiOBr-V/HNbO NS photocatalyst keeps high photocatalytic activity after five cycles under the identical experimental conditions, demonstrating its excellent long-term durability. This work provided an original strategy to design a new hybrid structure photocatalyst involved Vs, thus guiding a new way to further enhance CO reduction activity of photocatalyst.
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http://dx.doi.org/10.1016/j.jcis.2021.04.064DOI Listing
October 2021

In situ construction of multi-dimensional CoO/NiCoO hierarchical flakes on self-supporting carbon substrate with ultra-high capacitance for hybrid supercapacitors.

J Colloid Interface Sci 2021 Oct 20;599:158-167. Epub 2021 Apr 20.

School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, 212013, PR China. Electronic address:

Research on environmentally friendly energy storage devices is an important strategy to solve the energy crisis and environmental pollution. Herein, a novel self-supporting electrode based on multi-dimensional CoO/NiCoO hierarchical flakes coating on graphene/carbon sphere (rGO/CS) conductive substrate is reasonably designed. Firstly, a simple hydrothermal method is used to synthesize NiCoO with both flake and nanoneedle morphology on the rGO/CS substrate. Subsequently, CoO/[email protected]/CS is obtained by in-situ growth of metal organic frameworks polyhedrons on the surface of NiCoO flakes followed by calcination. In the unique structure, benefitting from the synergy between the substrate and multi-element transition metal oxides, the integrated film shows good conductivity, high specific surface area and abundant active sites. Thus, the binder-free electrode exhibits an ultra-high specific capacitance of 3876.6 F g (538.4 mA h g) at 1 A g. A hybrid supercapacitor is assembled with activated carbon as the negative electrode and CoO/[email protected]/CS as the positive electrode, the device shows a highest energy density of 56.5 Wh kg at a power density of 800 W kg. After 6000 charge-discharge cycles, 92.5% of the initial capacitance can be still maintained, indicating its good application prospects in energy storage materials.
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http://dx.doi.org/10.1016/j.jcis.2021.04.036DOI Listing
October 2021

CMTM8 as an LPA1-associated partner mediates lysophosphatidic acid-induced pancreatic cancer metastasis.

Ann Transl Med 2021 Jan;9(1):42

Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.

Background: Lysophosphatidic acid (LPA) is known to promote cancer cell invasiveness through LPA1, but the downstream signaling cascades are still not fully clarified. The CKLF-like MARVEL transmembrane domain-containing (CMTM) family regulates aggressive phenotype in many cancers.

Methods: We performed LPA1 co-immunoprecipitation combined with mass spectrometry to search for LPA1-associated proteins. The role of CMTM8 in mediating the pro-invasive activity of LPA was investigated in pancreatic cancer.

Results: We identified CMTM8 as an LPA1-interacting protein. LPA1 and CMTM8 were co-localized in pancreatic cancer cells. LPA treatment led to stabilization of CMTM8 protein, which was impaired by knockdown of LPA1. Depletion of CMTM8 significantly suppressed the migration and invasion of pancreatic cancer cells. Conversely, ectopic expression of CMTM8 enhanced the migratory and invasive capacity of pancreatic cancer cells. CMTM8 depletion blocked the formation of metastatic lesions in the lung. Knockdown of CMTM8 attenuated LPA-induced migration and invasion in pancreatic cancer cells. CMTM8 overexpression stimulated β-catenin activation through reduction of GSK3β. In addition, knockdown of β-catenin dramatically antagonized CMTM8-mediated migration and invasion in pancreatic cancer cells.

Conclusions: CMTM8 serves as a key mediator of LPA-induced invasiveness in pancreatic cancer. The interaction between CMTM8 and LPA1 leads to activation of oncogenic β-catenin signaling. CMTM8 represents a potential therapeutic target for pancreatic cancer.
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http://dx.doi.org/10.21037/atm-20-1013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859753PMC
January 2021

Bone marrow-derived mesenchymal stem cells microvesicles stabilize atherosclerotic plaques by inhibiting NLRP3-mediated macrophage pyroptosis.

Cell Biol Int 2021 Apr 28;45(4):820-830. Epub 2020 Dec 28.

Department of Ultrasonography, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.

Rupture of atherosclerotic plaques constitutes the major cause of thrombosis and acute ischemic coronary syndrome. Bone marrow-derived mesenchymal stem cells microvesicles (BMSCs-MVs) are reported to promote angiogenesis. This study investigated the role of BMSCs-MVs in stabilizing atherosclerotic plaques. BMSCs-MVs in mice were isolated and identified. The mouse model of atherosclerosis was established, and mice were injected with BMSCs-MVs via the tail vein. The macrophage model with high glucose and oxidative damage was established and then incubated with BMSCs-MVs. Nod-like receptor protein 3 (NLRP3) expression, pyroptosis-related proteins, and inflammatory factors were detected. Actinomycin D was used to inhibit the secretion of BMSCs-MVs to verify the source of microRNA-223 (miR-223). The binding relationship between miR-223 and NLRP3 was predicted and verified. BMSCs-MVs with knockdown of miR-223 were cocultured with bone marrow-derived macrophages with knockdown of NLRP3, and then levels of miR-223, NLRP3, pyroptosis-related proteins, and inflammatory factors were detected. BMSCs-MVs could reduce the vulnerability index of atherosclerotic plaques and intima-media thickness in mice, and inhibit pyroptosis and inflammation. BMSCs-MVs inhibited pyroptosis and inflammatory factors in macrophages. BMSCs-MVs carried miR-223 to inhibit NLRP3 expression and reduce macrophage pyroptosis, thereby stabilizing the atherosclerotic plaques.
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http://dx.doi.org/10.1002/cbin.11526DOI Listing
April 2021

A Novel Method for Accurate Preoperative Templating for Total Hip Arthroplasty Using a Biplanar Digital Radiographic (EOS) System.

JB JS Open Access 2020 Oct-Dec;5(4). Epub 2020 Oct 28.

Departments of Orthopaedic Surgery (J.H., Z.Z., W.S., and J.L.), Clinical Pharmacology (Y.Z.), and Quality Management (W.M.), the First Affiliated Hospital of Soochow University, Suzhou, People's Republic of China.

Background: Accurate preoperative planning for total hip arthroplasty (THA) relies on conventional anteroposterior radiographs. The difficulty of determining the magnification factor of radiographs is a major limitation. Despite the use of markers for calibration, identifying the plane of the hip joint is a major challenge. The aim of this study was to evaluate the accuracy of a novel method for image calibration and preoperative planning in THA involving the use of a biplanar radiographic (EOS imaging) system and a self-designed coin device.

Methods: Biplanar radiographs (with the self-designed coin device) and a conventional anteroposterior radiograph (with a coin) were made for 26 patients after primary THA. The agreement between the actual and calculated diameters for each method was assessed using the concordance correlation coefficient (CCC) and Bland-Altman plots. In addition, 15 patients undergoing primary THA were prospectively enrolled to evaluate the EOS imaging-based method (EOS method), with biplanar radiographs made with use of the coin device. The accuracy of the preoperative predicted size of the implants was evaluated.

Results: Both the EOS and conventional anteroposterior radiograph-based methods were reliable in repeated measurements of the diameter of the artificial femoral head in the reproducibility study, with the average CCCs for both methods >0.990. The agreement between the actual and EOS-based calculated diameters of the artificial femoral head was excellent, with a CCC of >0.990, while the agreement was poor between the actual and anteroposterior radiograph-based calculated diameters, with a CCC of <0.75. The EOS method exhibited a lower absolute difference (0.09 ± 0.07 mm) between the actual and calculated diameters compared with conventional anteroposterior radiography (1.26 ± 0.86 mm) (p < 0.001). EOS-based preoperative plans also exhibited excellent performance on the accuracy of the planning of the cups and stems; only 1 patient (6.7%) had a final implanted cup that differed by 1 size from the predicted size. Two patients (13.3%) had final implanted stems that differed by 1 size from the predicted size, and for 1 patient (6.7%), the stem size was off by ≥2 sizes.

Conclusions: We describe a novel and easy-to-use method for the accurate calibration of radiographs and preoperative planning for THA. The EOS method evaluated in this study is an alternative method for preoperative planning in clinical practice.
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http://dx.doi.org/10.2106/JBJS.OA.20.00078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592990PMC
October 2020

Self-supported nickel sulfide derived from nickel foam for hydrogen evolution and oxygen evolution reaction: effect of crystal phase switching.

Nanotechnology 2021 Feb;32(8):085710

School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, People's Republic of China.

Designing and fabricating economically viable, high active and stable electrocatalysts play an important role for hydrogen evolution reaction (HER) and oxygen evolution reaction (OER). Crystal phase is the crucial factor that governs the electrochemical property and electrocatalytic reaction pathways. Here, a one-step nickel foam derived sulfidation method was presented to synthesize self-supported NiS and NiS. The crystal phase-dependent chemical properties related to electrocatalytic behavior were evaluated by a series of advanced characterization and density functional theory calculations. Overall, the self-supported NiS shows high electrochemical activity towards both HER and OER in alkaline conditions, which afford the current density of 10 mA cm with overpotentials of 245 mV for OER and 123 mV for HER, respectively. When employed the self-supported NiS as the bifunctional electrocatalysts for overall water splitting, the entire device provides the current density of 10 mA cm at 1.61 V. These results indicate that the electrocatalytic properties can be exert greater improved by controlling the crystal phase, offering the prospect for advanced materials design and development.
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http://dx.doi.org/10.1088/1361-6528/abc852DOI Listing
February 2021

Ink-Assisted Synthetic Strategy for Stable and Advanced Composite Electrocatalysts with Single Fe Sites.

Small 2020 Dec 30;16(52):e2006113. Epub 2020 Nov 30.

School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, 212013, China.

The oxygen evolution reaction is critical to the efficiency of many energy technologies that store renewable electricity in chemical form. However, the rational design of high-performance and stable catalysts to drive this reaction remains a formidable challenge. Here, a facile ink-assisted strategy to construct a series of stable and advanced composite electrocatalysts with single Fe sites for permitting seriously improved performance characteristics is reported. As revealed by a suit of characterization techniques and theoretical methods, the improved electrocatalytic performance and stability can be attributed to the unique coordination states of Fe in the form of distorted FeO C and the interfacial effect in the composite system that optimize and stabilize single Fe sites in changing to better configurations for intermediates adsorption. The findings provide a novel strategy to in-depth understanding of practical guidelines for the electrocatalyst design for energy conversion devices.
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http://dx.doi.org/10.1002/smll.202006113DOI Listing
December 2020

A NIR-Responsive Phytic Acid Nickel Biomimetic Complex Anchored on Carbon Nitride for Highly Efficient Solar Hydrogen Production.

Angew Chem Int Ed Engl 2021 03 14;60(10):5245-5249. Epub 2021 Jan 14.

School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, 212013, P. R. China.

A challenge in photocatalysis consists in improving the efficiency by harnessing a large portion of the solar spectrum. We report the design and realization of a robust molecular-semiconductor photocatalytic system (MSPS) consisting of an earth-abundant phytic acid nickel (PA-Ni) biomimetic complex and polymeric carbon nitride (PCN). The MSPS exhibits an outstanding activity at λ=940 nm with high apparent quantum efficiency (AQE) of 2.8 %, particularly λ>900 nm, as it outperforms all reported state-of-the-art near-infrared (NIR) hybrid photocatalysts without adding any noble metals. The optimum hydrogen (H ) production activity was about 52 and 64 times higher with respect to its pristine counterpart under the AM 1.5 G and visible irradiation, respectively, being equivalent to the platinum-assisted PCN. This work sheds light on feasible avenues to prepare highly active, stable, cheap NIR-harvesting photosystems toward sustainable and scalable solar-to-H production.
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http://dx.doi.org/10.1002/anie.202014317DOI Listing
March 2021

Boosted Photoelectrochemical N Reduction over MoC In Situ Coated with Graphitized Carbon.

Langmuir 2020 Dec 24;36(48):14802-14810. Epub 2020 Nov 24.

School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, P. R. China.

Photoelectrochemical N reduction reaction (PEC NRR) is a promising method to solve the problems of environmental protection and energy sustainability. However, the strong chemical stability of the N≡N bond and competitive hydrogen evolution reaction (HER) cause the nonideal efficiency of N → NH conversion in actual operation. For the first time, a MoC/C heterostructure was fabricated as a PEC cathode for N reduction under environmental conditions. The MoC/C heterostructure could effectively decrease the coverage of hydrogen spillover and inhibit the competitive HER, resulting in a desirable selectivity for N activation. Meanwhile, the decoration of the C shell further promoted the stability and conductivity of MoC. Mo sites of MoC were considered as activation centers, which played a dominant role in the final PEC performance. An optimal NH yield rate of up to 6.6 μg h mg was achieved with the MoC/C heterostructure, which was almost 3 times that with pristine C. The faradic efficiency (FE) of the MoC/C heterostructure was 37.2% at 0.2 V (vs Ag/AgCl). This work not only provides an insight into the interplay between the MoC/C heterostructure and N activation, but also reveals its great potential in NH synthesis by a green route.
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http://dx.doi.org/10.1021/acs.langmuir.0c02770DOI Listing
December 2020

Amorphous MnCO/C Double Layers Decorated on BiVO Photoelectrodes to Boost Nitrogen Reduction.

ACS Appl Mater Interfaces 2020 Nov 10;12(47):52763-52770. Epub 2020 Nov 10.

School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, P. R. China.

NH is mainly obtained by the Haber-Bosch method in the process of industrial production, which is not only accompanied by huge energy consumption but also environmental pollution. The reduction of N to NH under mild conditions is an important breakthrough to solve the current energy and environmental problems, so the preparation of catalysts that can effectively promote the reduction of N is a crucial step. In this work, BiVO decorated with amorphous MnCO/C double layers has been successfully synthesized by a one-step method for the first time. The C and MnCO have been formed as ultrathin film, which enables the establishment of a uniform and tight interface with BiVO. The temperature-programmed desorption of N (N-TPD) spectra confirmed that the MnCO/C could endow BiVO with a drastic enhancement of the chemical absorption ability of a N molecule compared with the pristine BiVO. Meanwhile, the method of isotope labeling proved that the catalyst exhibited excellent selectivity for the photocatalytic nitrogen reduction reaction (NRR). The production rate of NH up to 2.426 mmol m h has been achieved over the BiVO/MnCO/C, which is almost 8 times that of pristine BiVO. The promoted production rate of NH over BiVO/MnCO/C could be mainly attributed to the cooperative process between MnCO and C amorphous layers. Therefore, this work could provide an alternative insight to understand the NRR process based on the model of a hierarchical amorphous structure.
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http://dx.doi.org/10.1021/acsami.0c16337DOI Listing
November 2020

3D CNTs/graphene network conductive substrate supported MOFs-derived CoZnNiS nanosheet arrays for ultra-high volumetric/gravimetric energy density hybrid supercapacitor.

J Colloid Interface Sci 2021 Feb 15;583:288-298. Epub 2020 Sep 15.

School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, PR China. Electronic address:

With the increasing demand for miniaturization and portable energy storage system, it is an urgent necessary that developing high volumetric energy density supercapacitors with small volumes. Herein, an integrated self-supporting [email protected]/rGO composite film electrode with the thickness of about 6 μm was designed. In the unique structure, porous CNTs/rGO film is served as conductive substrate to support the CoZn-MOFs derived vertically oriented two-dimensional CoZnNiS nanoarrays. The self-supporting film endows the electrode a high volumetric mass density of 1.28 g cm and superior electron-ion transport channel, which displays a maximum specific capacitance of 1349.2 F g as well as high volumetric capacity of 1727.0 F cm at 1 A g. Besides, a porous film of pure carbon materials (carbon spheres integrated graphene) was designed and used as the negative electrode in supercapacitor. When assembled a hybrid supercapacitor based on the above two self-supporting electrodes, the device delivers up an ultra-high volumetric/gravimetric energy density of 65.2 W h L (60.4 W h kg) at a power density of 1308 W L (1200 W kg). Moreover, the asymmetric supercapacitor also displays an ultra-long lifetime with 90.6% retention after 10,000 cycles. These outstanding performances make the [email protected]/rGO electrode could be a promising candidate for next-generation high volumetric/gravimetric energy density supercapacitors, especially in the limited space.
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http://dx.doi.org/10.1016/j.jcis.2020.08.128DOI Listing
February 2021

Single cell electron collectors for highly efficient wiring-up electronic abiotic/biotic interfaces.

Nat Commun 2020 08 14;11(1):4087. Epub 2020 Aug 14.

Biofuels Institute, School of Environment and Safety Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang, 212013, China.

By electronically wiring-up living cells with abiotic conductive surfaces, bioelectrochemical systems (BES) harvest energy and synthesize electric-/solar-chemicals with unmatched thermodynamic efficiency. However, the establishment of an efficient electronic interface between living cells and abiotic surfaces is hindered due to the requirement of extremely close contact and high interfacial area, which is quite challenging for cell and material engineering. Herein, we propose a new concept of a single cell electron collector, which is in-situ built with an interconnected intact conductive layer on and cross the individual cell membrane. The single cell electron collector forms intimate contact with the cellular electron transfer machinery and maximizes the interfacial area, achieving record-high interfacial electron transfer efficiency and BES performance. Thus, this single cell electron collector provides a superior tool to wire living cells with abiotic surfaces at the single-cell level and adds new dimensions for abiotic/biotic interface engineering.
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http://dx.doi.org/10.1038/s41467-020-17897-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429851PMC
August 2020

Reliability and concurrent validity of angle measurements in lower limb: EOS 3D goniometer versus 2D manual goniometer.

J Orthop Translat 2020 Sep 20;24:96-102. Epub 2020 May 20.

Department of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.

Background: In clinical routine, preoperative radiographic assessment of lower extremity geometry relies on conventional X-rays. However, the plane goniometric measuring has several limitations in accurately locating anatomical landmarks. The purpose of this study is to propose a fast and accurate 3D-reconstruction-method based on biplanar X-rays with clinical measurements assessment in standing position.

Methods: 50 candidates for HTO or DFO with deformity of the lower extremities were included in this study. Biplanar X-rays were performed using the EOS imaging system in conventional double-stance full weight-bearing position (DS) and shifted-foot standing position (SF). The results of hip-knee-ankle angle (HKAA), lateral distal femoral angle (LDFA), and medial proximal tibial angle (MPTA) were evaluated by either 2D manual goniometer (MG) based on X-ray in DS standing position or 3D-reconstruction goniometer based on X-rays in SF standing position.

Results: For the reproducibility study, MG and EOS goniometer were both reliable in repeated measures of HKAA, LDFA, and MPTA, with average concordance correlation coefficients (CCCs) all above 0.910. The agreements between MG and EOS measurements were high for HKAA and LDFA with CCCs all above 0.90, while the agreement was low for MPTA with CCC below 0.75. Further linear regression model analysis also revealed a significant correlation between MG and EOS measurements for HKAA (all R ≥ 0.93) and LDFA (all R ≥ 0.90), but not for MPTA (all R ≤ 0.522).

Conclusion: In comparison with the traditional 2D manual goniometer, EOS 3D reconstruction based goniometric measuring could provide equivalent results of HKAA and LDFA, and potentially a more accurate result of MPTA. These findings suggest that EOS 3D reconstruction based goniometric measuring is suitable for preoperative evaluation and planning for HTO/DFO. However, future improvements of the 3D reconstruction method are needed for better detection of the femoral condyles and tibial plates without the requirement of shifted-foot standing position.

The Translational Potential Of This Article: EOS 3D reconstruction based goniometric measuring could provide equivalent or even more accurate results of HKAA, LDFA, and MPTA, in comparison with the traditional 2D manual goniometer, making it suitable for preoperative evaluation and planning for HTO/DFO.
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http://dx.doi.org/10.1016/j.jot.2020.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7390786PMC
September 2020

Dual directions to address the problem of aseptic loosening via electrospun PLGA @ aspirin nanofiber coatings on titanium.

Biomaterials 2020 10 13;257:120237. Epub 2020 Jul 13.

State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing, 100084, People's Republic of China; Key Laboratory of Advanced Materials of Ministry of Education of China, School of Materials Science and Engineering, Tsinghua University, Beijing, 100084, People's Republic of China. Electronic address:

Peri-implant aseptic inflammation and osteolysis can cause aseptic loosening, leading to the failure of implants. Therefore, aseptic loosening of orthopedic implants remains an imminent problem for the development of durable and effective implants. In this work, a common anti-inflammatory drug (aspirin, ASA) was loaded in poly(lactic-co-glycolic acid) (PLGA) to construct nanofiber coatings on titanium (Ti) via electrospinning. The adhesion of the nanofiber coatings to Ti was ensured by polydopamine (PDA) modification. A stable and sustainable release of aspirin from the nanofiber coatings could last up to 60 days. Such electrospun [email protected] nanofiber coatings could promote proliferation and osteogenic differentiation of bone mesenchymal stem cells (BMSCs) as well as inhibit M1 polarization and RANKL-induced osteoclast differentiation of macrophages in vitro. These results indicated that this facile formulation of the [email protected] nanofiber coatings for long-term drug release could be expected to address the problem of aseptic loosening effectively in dual directions of both anti-inflammation and improving osseointegration simultaneously. Notably, the in vivo experiments demonstrated that [email protected] nanofiber coatings did promote osseointegration ability of Ti implants significantly, even in challenging condition with wear particles, and also effectively inhibited Ti particle induced osteolysis around the implants. This work indicates a promising way for the development of durable and effective implants by using [email protected] to address the problem of aseptic loosening in dual directions.
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http://dx.doi.org/10.1016/j.biomaterials.2020.120237DOI Listing
October 2020

Ag-Pi/BiVO heterojunction with efficient interface carrier transport for photoelectrochemical water splitting.

J Colloid Interface Sci 2020 Nov 30;579:619-627. Epub 2020 Jun 30.

School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, PR China. Electronic address:

The limitation of pristine BiVO photoanode severely causes the high carrier recombination efficiency and low energy conversion efficiency in the photoelectrochemical (PEC) system. In this work, the Ag-Pi/BiVOn-n heterojunction has been rationally designed and fabricated for efficient PEC water splitting, through successive ionic layer adsorption reaction method. The built-in field of Ag-Pi/BiVO significantly promotes the separation efficiency of photogenerated carriers, benefiting for the participation of abundant holes in water oxidation. The photocurrent density of 40-Ag-Pi/BiVO has been enhanced to 2.32 mA/cm, which is 4.5 times than that of the pristine BiVO. Compared with the pristine BiVO (6.5%), the IPCE value of 40-Ag-Pi/BiVO achieves 22% (410 nm, 1.23V). In addition, the charge injection efficiency (η) and charge separation efficiency (η) of 40-Ag-Pi/BiVO have been achieved to 74.36% (1.23 V) and 31.57% (1.23 V), respectively, revealing the excellent carriers' transfer behavior in the both bulk and interface. The desirable stability endows Ag-Pi/BiVO system with a great potential in the practical application in PEC water splitting, and the corresponding mechanism for in-depth understanding the process of carriers' transfer in Ag-Pi/BiVO structure has been also proposed. Therefore, the construction of Ag-Pi/BiVO heterojunction will provide a new insight for the configuration of efficient PEC system.
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http://dx.doi.org/10.1016/j.jcis.2020.06.108DOI Listing
November 2020

Low Temperature CO Reforming with Methane Reaction over CeO-Modified [email protected] Catalysts.

ACS Appl Mater Interfaces 2020 Aug 22;12(31):35022-35034. Epub 2020 Jul 22.

School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China.

Developing high performance catalysts for the low temperature CO reforming with methane (CRM) reaction is a challenge due to the occurrences of metal sintering and carbon deposition. In this study, we synthesized CeO modified [email protected] catalysts with excellent properties of sintering-resistance and low carbon deposition for high performance low temperature CRM. The [email protected] catalysts displayed a size effect from tiny Ni nanoparticles to enhance CRM performance and a confinement effect from silica encapsulation to limit Ni sintering and exhibited oxygen storage capacity from ceria to reduce carbon deposition. Performance and characterization results revealed that the [email protected] catalyst with smaller ceria size exhibited higher performance and lower carbon deposition than the [email protected] catalyst with bigger ceria size, because the smaller ceria nanoparticles activated more CO. This work provided a simple strategy to deposit small sized ceria on the [email protected] catalyst surface for the performance enhancement of low temperature CRM.
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http://dx.doi.org/10.1021/acsami.0c09371DOI Listing
August 2020

Exploration of prognostic index based on immune-related genes in patients with liver hepatocellular carcinoma.

Biosci Rep 2020 07;40(7)

Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.

The present study aimed to screen the immune-related genes (IRGs) in patients with liver hepatocellular carcinoma (LIHC) and construct a synthetic index for indicating the prognostic outcomes. The bioinformatic analysis was performed on the data of 374 cancer tissues and 50 normal tissues, which were downloaded from TCGA database. We observed that 17 differentially expressed IRGs were significantly associated with survival in LIHC patients. These LIHC-specific IRGs were validated with function analysis and molecular characteristics. Cox analysis was applied for constructing a RiskScore for predicting the survival. The RiskScore involved six IRGs and corresponding coefficients, which was calculated with the following formula: RiskScore = [Expression level of FABP5 *(0.064)] + [Expression level of TRAF3 * (0.198)] + [Expression level of CSPG5 * (0.416)] + [Expression level of IL17D * (0.197)] + [Expression level of STC2 * (0.036)] + [Expression level of BRD8 * (0.140)]. The RiskScore was positively associated with the poor survival, which was verified with the dataset from ICGC database. Further analysis revealed that the RiskScore was independent of any other clinical feature, while it was linked with the infiltration levels of six types of immune cells. Our study reported the survival-associated IRGs in LIHC and then constructed IRGs-based RiskScore as prognostic indicator for screening patients with high risk of short survival. Both the screened IRGs and IRGs-based RiskScore were clinically significant, which may be informative for promoting the individualized immunotherapy against LIHC.
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http://dx.doi.org/10.1042/BSR20194240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327182PMC
July 2020

FBXL6 governs c-MYC to promote hepatocellular carcinoma through ubiquitination and stabilization of HSP90AA1.

Cell Commun Signal 2020 06 23;18(1):100. Epub 2020 Jun 23.

Department of Integrative Oncology, Fudan University Shanghai Cancer Center, 270 Dong An Road, Shanghai, 200032, China.

Background: Heat shot protein 90 (HSP90) AA1 functions as an onco-protein to regulate the assembly, manipulation, folding and degradation of its client proteins, including c-MYC. However, little is known about the mechanism of HSP90AA1 regulation.

Methods: Transcriptome RNA-sequencing data of hepatocellular carcinoma (HCC) samples were used to detect the mRNA expression of FBXL6. Immunoprecipitation/Mass Spectrum (IP/MS) method was used to identify the interacting proteins of FBXL6. The co-immunoprecipitation assay was used to determine the interaction between FBXL6 and HSP90AA1. The in vivo ubiquitination assay was performed to determine the regulation of HSP90AA1 by FBXL6. Luciferase reporter and chromatin immunoprecipitation (ChIP) assays were used to determine the transcriptional regulation of FBXL6 by c-MYC. Immunohistochemical (IHC) staining was performed to study the correlation of FBXL6 and HSP90AA1 protein expression in 87 HCC samples. Cell counting and colony formation assays were implemented to detect the biological effects of FBXL6 on the growth of HCC cells in vitro. The effect of FBXL6 on HCC tumor growth in vivo was studied in a tumor xenograft model in mice.

Results: Here, we identified the orphan F-box protein FBXL6, a substrate recognition subunit of an SCF (Skp1-Cul1-F-box protein) complex, as the ubiquitin ligase for HSP90AA1. FBXL6 promoted K63-dependent ubiquitination of HSP90AA1 to stabilize it. Through analysis of the TCGA dataset, we found that FBXL6 was significantly increased in HCC tissues and positively correlated with c-MYC pathway. FBXL6 accumulation in HCC causes the stabilization and activation of c-MYC by preventing HSP90AA1 degradation. The activated c-MYC directly binds to the promoter region of FBXL6 to induce its mRNA expression.

Conclusion: Collectively, our data revealed an unknown FBXL6-HSP90AA1-c-MYC axis which might contribute to the oncogenesis of HCC, and we propose that inhibition of FBXL6 might represent an effective therapeutic strategy for HCC treatment. Video abstract.
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http://dx.doi.org/10.1186/s12964-020-00604-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310287PMC
June 2020

Hierarchical [email protected](OH)·0.75HO core-shell nanosheet arrays on carbon cloth for high-performance supercapacitors.

J Colloid Interface Sci 2020 Oct 30;578:1-9. Epub 2020 May 30.

School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, PR China. Electronic address:

The research on the structure tuning of CoP in supercapacitors has received extensive attention. However, low specific capacitance and energy density limit its further development. Here, we successfully synthesize the [email protected](OH)·0.75HO core-shell nanosheets structure on carbon cloth. CoP nanowires, as the core, can provide efficient charge transportation path for electron transfer, while the thin Ni(OH)·0.75HO nanosheets shell can increase the specific surface area and curtail the transport distance. As a result, the as-prepared [email protected](OH)·0.75HO nanosheet arrays electrode presents an outstanding specific capacity of 168.61 mAh g at 1 A g. The assembled asymmetric supercapacitor (ASC) of [email protected](OH)·0.75HO//activated carbon displays the highest energy density of 33.78 W h kg at 800 W kg, as well as the remarkable cycling stability (capacitance retention of 98.5% after 10,000 cycles). Furthermore, ten parallel LEDs can be powered up by two ASCs connected in series. Thus, this article provides a new idea for the core-shell structure prepared by using CoP as the skeleton.
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http://dx.doi.org/10.1016/j.jcis.2020.05.107DOI Listing
October 2020

Holey Cobalt-Iron Nitride Nanosheet Arrays as High-Performance Bifunctional Electrocatalysts for Overall Water Splitting.

ACS Appl Mater Interfaces 2020 Jul 17;12(26):29253-29263. Epub 2020 Jun 17.

Institute for Energy Research, Jiangsu University, Zhenjiang 212013, China.

Designing efficient metal nitride electrocatalysts with advantageous nanostructures toward overall water splitting is of great significance for energy conversion. In this work, holey cobalt-iron nitride nanosheet arrays grown on Ni foam substrate (CoFeN HNAs/NF) are prepared via a facile hydrothermal and subsequent thermal nitridation method. This unique HNA architecture can not only expose abundant active sites but also facilitate the charge/mass transfer. Resulting from these merits, the CoFeN HNAs/NF exhibits high catalytic performance with overpotentials of 200 and 260 mV at 10 mA cm for the hydrogen evolution reaction (HER) and 50 mA cm for the oxygen evolution reaction (OER), respectively. Furthermore, when using CoFeN-500 HNAs/NF as both anode and cathode, the alkaline electrolyzer could afford a current density of 10 mA cm at 1.592 V, higher than many other metal nitride-based electrocatalysts. This work signifies a simple approach to prepare holey metal nitride nanosheet arrays, which can be applied in various fields of energy conversion and storage.
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http://dx.doi.org/10.1021/acsami.0c05219DOI Listing
July 2020

miR-125b suppresses cell proliferation and metastasis by targeting HAX-1 in esophageal squamous cell carcinoma.

Pathol Res Pract 2020 Feb 17;216(2):152792. Epub 2019 Dec 17.

Department of Thoracic Surgery, The Second People's Hospital of Nantong, Nantong, Jiangsu, China. Electronic address:

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http://dx.doi.org/10.1016/j.prp.2019.152792DOI Listing
February 2020

The novel HLA-B*58:118 allele was identified during high-resolution HLA typing.

HLA 2020 03 9;95(3):214-215. Epub 2019 Dec 9.

Science and Education Section, Wuhan Institute of Dermatology and Venereology, Wuhan, Hubei, China.

HLA-B*58:118 differs from HLA-B*58:01:01:01 by one nucleotide exchange at position 556(G>A) with an amino exchange.
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http://dx.doi.org/10.1111/tan.13758DOI Listing
March 2020

Multiple Doped Carbon Nitrides with Accelerated Interfacial Charge/Mass Transportation for Boosting Photocatalytic Hydrogen Evolution.

ACS Appl Mater Interfaces 2019 Jun 12;11(25):22255-22263. Epub 2019 Jun 12.

The interaction of water molecule with catalysts is crucial to photocatalysis, but the surface property manipulation still remains a great challenge. In this study, we report an in situ multiple heteroelement (sodium, oxygen, and iodide) doping strategy based on a molten salt-assisted route to prepare a green-colored carbon nitride (GCN). The as-prepared GCN yields 25.5 times higher H evolution rate than that of bulk polymeric carbon nitride under visible light. Experimental characterization data demonstrate that the GCN delivers upshift of the conduction band and increased specific surface area and hydrophilicity. As confirmed by time-resolved PL spectra, DMPO spin-trapping EPR analysis, and so on, the excellent activity is dominantly ascribed to the greatly enhanced hydrophilicity and, subsequently, efficient interfacial charge transfer and hydrogen liberation. Moreover, through surface charge modification, the GCN also shows an increased degradation activity of rhodamine B. This work highlights the importance of surface modulation through multiple earth-abundant element incorporation for designing of advanced and practical photocatalysts.
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http://dx.doi.org/10.1021/acsami.9b03745DOI Listing
June 2019
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