Publications by authors named "Weidong Fei"

45 Publications

Bifunctional Electrocatalysts Based on Mo-Doped NiCoP Nanosheet Arrays for Overall Water Splitting.

Nanomicro Lett 2019 Jul 13;11(1):55. Epub 2019 Jul 13.

State Key Laboratory of Advanced Welding and Joining, Harbin Institute of Technology, Harbin, 150001, People's Republic of China.

Rational design of efficient bifunctional electrocatalysts is highly imperative but still a challenge for overall water splitting. Herein, we construct novel freestanding Mo-doped NiCoP nanosheet arrays by the hydrothermal and phosphation processes, serving as bifunctional electrocatalysts for overall water splitting. Notably, Mo doping could effectively modulate the electronic structure of NiCoP, leading to the increased electroactive site and improved intrinsic activity of each site. Furthermore, an electrochemical activation strategy is proposed to form Mo-doped (Ni,Co)OOH to fully boost the electrocatalytic activities for oxygen evolution reaction. Benefiting from the unique freestanding structure and Mo doping, Mo-doped NiCoP and (Ni,Co)OOH show the remarkable electrochemical performances, which are competitive among current researches. In addition, an overall water splitting device assembled by both electrodes only requires a cell voltage of 1.61 V to reach a current density of 10 mA cm. Therefore, this work opens up new avenues for designing nonprecious bifunctional electrocatalysts by Mo doping and in situ electrochemical activation.
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http://dx.doi.org/10.1007/s40820-019-0289-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7770736PMC
July 2019

A highly conductive Ni(OH) nano-sheet wrapped CuCoS nano-tube electrode with a core-shell structure for high performance supercapacitors.

Dalton Trans 2021 Jun;50(24):8476-8486

School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, China.

The design of microstructures and the optimum selection of electrode materials have substantial effects on the electrochemical performances of supercapacitors. A core-shell structured [email protected](OH)2 electrode material was designed, with CuCo2S4 nanotubes as the core wrapped by interlaced Ni(OH)2 nano-sheets as the shell. The hydrothermal and electro-deposition processes were adopted to synthesize [email protected](OH)2 materials. The CuCo2S4 nanotubes can both provide specific capacitance and act as a "superhighway" for electrons due to their highly conductive skeleton structure. The Ni(OH)2 nano-sheets will boost the electrochemically active sites and enhance the specific surface area. Meanwhile, the mutually restricted core-shell [email protected](OH)2 electrode could regulate the volume deformation to improve its stability. The [email protected](OH)2 electrode had a maximum specific capacitance of 2668.4 F g-1 at a current density of 1 A g-1 and a superior cycling stability of 90.3% after 10 000 cycles. Moreover, a [email protected](OH)2//active carbon asymmetric supercapacitor with a maximum energy density of 44 W h kg-1 was assembled, suggesting that [email protected](OH)2 is a successful binder-free electrode material for high performance supercapacitors.
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http://dx.doi.org/10.1039/d1dt01075aDOI Listing
June 2021

Extracellular Matrix: Emerging Roles and Potential Therapeutic Targets for Breast Cancer.

Front Oncol 2021 22;11:650453. Epub 2021 Apr 22.

Department of Pharmacy, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Increasing evidence shows that the extracellular matrix (ECM) is an important regulator of breast cancer (BC). The ECM comprises of highly variable and dynamic components. Compared with normal breast tissue under homeostasis, the ECM undergoes many changes in composition and organization during BC progression. Induced ECM proteins, including fibrinogen, fibronectin, hyaluronic acid, and matricellular proteins, have been identified as important components of BC metastatic cells in recent years. These proteins play major roles in BC progression, invasion, and metastasis. Importantly, several specific ECM molecules, receptors, and remodeling enzymes are involved in promoting resistance to therapeutic intervention. Additional analysis of these ECM proteins and their downstream signaling pathways may reveal promising therapeutic targets against BC. These potential drug targets may be combined with new nanoparticle technologies. This review summarizes recent advances in functional nanoparticles that target the ECM to treat BC. Accurate nanomaterials may offer a new approach to BC treatment.
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http://dx.doi.org/10.3389/fonc.2021.650453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100244PMC
April 2021

Engineering of bioactive metal sulfide nanomaterials for cancer therapy.

J Nanobiotechnology 2021 Mar 31;19(1):93. Epub 2021 Mar 31.

Department of Pharmacy, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China.

Metal sulfide nanomaterials (MeSNs) are a novel class of metal-containing nanomaterials composed of metal ions and sulfur compounds. During the past decade, scientists found that the MeSNs engineered by specific approaches not only had high biocompatibility but also exhibited unique physicochemical properties for cancer therapy, such as Fenton catalysis, light conversion, radiation enhancement, and immune activation. To clarify the development and promote the clinical transformation of MeSNs, the first section of this paper describes the appropriate fabrication approaches of MeSNs for medical science and analyzes the features and limitations of each approach. Secondly, we sort out the mechanisms of functional MeSNs in cancer therapy, including drug delivery, phototherapy, radiotherapy, chemodynamic therapy, gas therapy, and immunotherapy. It is worth noting that the intact MeSNs and the degradation products of MeSNs can exert different types of anti-tumor activities. Thus, MeSNs usually exhibit synergistic antitumor properties. Finally, future expectations and challenges of MeSNs in the research of translational medicine are spotlighted.
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http://dx.doi.org/10.1186/s12951-021-00839-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8011210PMC
March 2021

Preparation and Biological Property Evaluation of Novel Cationic Lipid-Based Liposomes for Efficient Gene Delivery.

AAPS PharmSciTech 2021 Jan 3;22(1):22. Epub 2021 Jan 3.

Pharmacy Department, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, 310006, China.

Novel cationic lipid-based liposomes prepared using an amphiphilic cationic lipid material, N,N-dimethyl-(N',N'-di-stearoyl-1-ethyl)1,3-diaminopropane (DMSP), have been proposed to enhance the transfection of nucleic acids. Herein, we designed and investigated liposomes prepared using DMSP, soybean phosphatidylcholine, and cholesterol. This novel gene vector has high gene loading capabilities and excellent protection against nuclease degradation. An in vitro study showed that the liposomes had lower toxicity and superior cellular uptake and transfection efficiency compared with Lipofectamine 2000. An endosomal escape study revealed that the liposomes demonstrated high endosomal escape and released their genetic payload in the cytoplasm efficiently. Mechanistic studies indicated that the liposome/nucleic acid complexes entered cells through energy-dependent endocytosis that was mediated by fossa proteins. These results suggest that such cationic lipid-based liposome vectors have potential for clinical gene delivery.
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http://dx.doi.org/10.1208/s12249-020-01868-wDOI Listing
January 2021

Regulating Gut Microbiome: Therapeutic Strategy for Rheumatoid Arthritis During Pregnancy and Lactation.

Front Pharmacol 2020 11;11:594042. Epub 2020 Nov 11.

Department of Pharmacy, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial inflammation and bone destruction. Microbial infection is considered to be the most important inducement of RA. The pregnancy planning of women in childbearing age is seriously affected by the disease activity of RA. Gut microbiome, related to immunity and inflammatory response of the host. At present, emerging evidence suggested there are significant differences in the diversity and abundance of gut microbiome during pregnancy and lactation, which may be associated with the fluctuation of RA disease activity. Based on these research foundations, we pioneer the idea of regulating gut microbiome for the treatment of RA during pregnancy and lactation. In this review, we mainly introduce the potential treatment strategies for controlling the disease activity of RA based on gut microbiome during pregnancy and lactation. Besides, we also briefly generalize the effects of conventional anti-rheumatic drugs on gut microbiome, the effects of metabolic changes during pregnancy on gut microbiome, alteration of gut microbiome during pregnancy and lactation, and the effects of anti-rheumatic drugs commonly used during pregnancy and lactation on gut microbiome. These will provide a clear knowledge framework for researchers in immune-related diseases during pregnancy. Regulating gut microbiome may be a potential and effective treatment to control the disease activity of RA during pregnancy and lactation.
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http://dx.doi.org/10.3389/fphar.2020.594042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7748111PMC
November 2020

The role of short-chain fatty acids in immunity, inflammation and metabolism.

Crit Rev Food Sci Nutr 2020 Dec 1:1-12. Epub 2020 Dec 1.

Department of Pharmacy, Women's Hospital School of Medicine Zhejiang University, Hangzhou, China.

Short-chain fatty acids (SCFAs) are carboxylic acids with carbon atom numbers less than 6, which are important metabolites of gut microbiome. Existing research shows that SCFAs play a vital role in the health and disease of the host. First, SCFAs are the key energy source for colon and ileum cells, and affect the intestinal epithelial barrier and defense functions by regulating related gene expression. Second, SCFAs regulate the function of innate immune cells to participate in the immune system, such as macrophages, neutrophils and dendritic cells. Third, SCFAs can also regulate the differentiation of T cells and B cells and the antigen-specific adaptive immunity mediated by them. Besides, SCFAs are raw materials for sugar and lipid synthesis, which provides a theoretical basis for studying the potential role of SCFAs in regulating energy homeostasis and metabolism. There are also studies showing that SCFAs inhibit tumor cell proliferation and promote apoptosis. In this article, we summarized in detail the role of SCFAs in immunity, inflammation and metabolism, and briefly introduced the role of SCFAs in tumor cell survival. It provides a systematic theoretical basis for the study of SCFAs as potential drugs to promote human health.
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http://dx.doi.org/10.1080/10408398.2020.1854675DOI Listing
December 2020

Bioactive metal-containing nanomaterials for ferroptotic cancer therapy.

J Mater Chem B 2020 12;8(46):10461-10473

Department of Pharmacy, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.

The clinical performance of the current cancer therapies is still far from satisfactory. The emerging ferroptosis-driven therapy strategies reignite the hope of chemotherapy in tumor treatment due to their incredible tumor suppression. Among ferroptosis-based cancer therapies, metal elements have attracted remarkable attention due to their inherent physicochemical properties in inducing ferroptosis of tumor cells quickly and strongly without complex cellular signal transduction. Although the discovery and applications of ferroptosis for tumor treatment have been discussed in many reviews, the unique advantages of metal-containing nanomaterials interfering ferroptotic cancer therapies (MIFCT) have seldom been mentioned. Here, we outline the latest advances of MIFCT comprehensively. Firstly, the functions of different kinds of metal elements or their ions are introduced to illustrate their advantages in MIFCT. Secondly, the emerging metal-containing nanomaterials that are designed to achieve ferroptosis-driven therapy are overviewed, including their ability to boost the Fenton or Fenton-like reaction for reactive oxygen species generation, act as hydrogen peroxide self-providers, damage the reducing system, and disturb cellular communication. Moreover, metal-containing nanomaterials with external energy conversion features for MIFCT are discussed. Finally, the future expectations and challenges of MIFCT for clinical cancer therapy are spotlighted.
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http://dx.doi.org/10.1039/d0tb02138eDOI Listing
December 2020

Recent Progress in Graphene/Polymer Nanocomposites.

Adv Mater 2021 Feb 6;33(6):e2001105. Epub 2020 Sep 6.

National Key Laboratory of Science and Technology on Advanced Composites in Special Environments, Harbin Institute of Technology, Harbin, 150080, P. R. China.

Nanocomposites, multiphase solid materials with at least one nanoscaled component, have been attracting ever-increasing attention because of their unique properties. Graphene is an ideal filler for high-performance multifunctional nanocomposites in light of its superior mechanical, electrical, thermal, and optical properties. However, the 2D nature of graphene usually gives rise to highly anisotropic features, which brings new opportunities to tailor nanocomposites by making full use of its excellent in-plane properties. Here, recent progress on graphene/polymer nanocomposites is summarized with emphasis on strengthening/toughening, electrical conduction, thermal transportation, and photothermal energy conversion. The influence of the graphene configuration, including layer number, defects, and lateral size, on its intrinsic properties and the properties of graphene/polymer nanocomposites is systematically analyzed. Meanwhile, the role of the interfacial interaction between graphene and polymer in affecting the properties of nanocomposites is also explored. The correlation between the graphene distribution in the matrix and the properties of the nanocomposite is discussed in detail. The key challenges and possible solutions are also addressed. This review may provide a constructive guidance for preparing high-performance graphene/polymer nanocomposite in the future.
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http://dx.doi.org/10.1002/adma.202001105DOI Listing
February 2021

Sustained delivery of 17β-estradiol by human amniotic extracellular matrix (HAECM) scaffold integrated with PLGA microspheres for endometrium regeneration.

Drug Deliv 2020 Dec;27(1):1165-1175

Department of Pharmacy, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

The endometrial injury usually results in intrauterine adhesions (IUAs). However, there is no effective treatment to promote the regeneration of the endometrium currently. The decellularized amnion membrane (AM) is a promising material in human tissue repair and regeneration due to its biocompatibility, biodegradability, as well as the preservation of abundant bioactive components. Here, an innovative drug-delivering system based on human amniotic extracellular matrix (HAECM) scaffolds were developed to facilitate endometrium regeneration. The 17β-estradiol (E) loaded PLGA microspheres (E-MS) were well dispersed in the scaffolds without altering their high porosity. E released from E-MS-HAECM scaffolds showed a decreased initial burst release followed with a sustained release for 21 days, which coincided with the female menstrual cycle. Results of cell proliferation suggested E-MS-HAECM scaffolds had good biocompatibility and provided more biologic guidance of endometrial cell proliferation except for mechanical supports. Additionally, the mRNA expression of growth factors in endometrial cells indicated that HAECM scaffolds could upregulate the expression of EGF and IGF-1 to achieve endometrium regeneration. Therefore, these advantages provide the drug-loaded bioactive scaffolds with new choices for the treatments of IUAs.
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http://dx.doi.org/10.1080/10717544.2020.1801891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470125PMC
December 2020

Targeted GSH-exhausting and hydroxyl radical self-producing manganese-silica nanomissiles for MRI guided ferroptotic cancer therapy.

Nanoscale 2020 Aug;12(32):16738-16754

Department of Pharmacy, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.

Ferroptosis, a cell death path induced by the generation of reactive oxygen species (ROS), will cause the accumulation of lipid peroxides (PL-PUFA-OOH) and achieve potent tumor-regression. However, glutathione (GSH)-dependent glutathione peroxidase 4 (GPx4) can reduce PL-PUFA-OOH and antagonize the ferroptosis inducing effect of ROS. Herein, folate-PEG modified dihydroartemisinin (DHA) loaded manganese doped mesoporous silica nanoparticles (described as nanomissiles) were constructed for integrating the effect of GSH exhaustion and ROS generation. After endocytosis by tumor cells, intracellular GSH triggered the degradation of nanomissiles, which allowed the simultaneous release of DHA and Fenton catalytic Mn2+ due to the redox reaction between the manganese-oxygen bonds and GSH. The degradation would lead to GSH exhaustion, activation of Mn2+-based magnetic resonance imaging (MRI), and DHA-driven ˙OH generation. The GSH-free environment inhibited the activity of GPx4 and enhanced the accumulation of PL-PUFA-OOH oxidized by ˙OH. Furthermore, the cooperative effects suppressed tumor metastasis by destroying the structure of polyunsaturated fatty acids in the cell membranes and showed potent antitumor activity. This innovative ferroptotic therapy integrating the GSH exhaustion and ROS generation will be a promising strategy for cancer therapy.
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http://dx.doi.org/10.1039/d0nr02396eDOI Listing
August 2020

The Role of Microbiomes in Pregnant Women and Offspring: Research Progress of Recent Years.

Front Pharmacol 2020 8;11:643. Epub 2020 May 8.

Department of Pharmacy, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Pregnancy is a complicated and delicate process, the maternal body undergoes changes on hormones, immunity, and metabolism during pregnancy to support fetal development. Microbiomes in the human body mainly live in the intestine, and the human gut microbiomes are complex, which composed of more than 500 to 1500 different bacteria, archaea, fungi, and viruses. Studies have shown that these microbiomes are not only involved in the digestion and absorption of food but also indispensable in regulating host health. In recent years, there has been increasing evidence that microbiomes are important for pregnant women and fetuses. During pregnancy, there will be great changes in gut microbiomes. Regulating gut microbiomes is beneficial to the health of the mother and the fetus. In addition, many complications during pregnancy are related to gut microbiomes, such as gestational diabetes, obesity, preeclampsia, digestive disorders, and autoimmune diseases. Moreover, the microbiomes in mother's milk and vagina are closely related to the colonization of microbiomes in the early life of infants. In this review, we systematically review the role of maternal microbiomes in different gestational complications, and elucidate the function and mechanism of maternal microbiomes in the neural development and immune system of offspring. These will provide a clear knowledge framework or potential research direction for researchers in related fields.
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http://dx.doi.org/10.3389/fphar.2020.00643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225329PMC
May 2020

Construction of arsenic-metal complexes loaded nanodrugs for solid tumor therapy: A mini review.

Int J Pharm 2020 Jun 4;583:119385. Epub 2020 May 4.

Department of Pharmacy, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China. Electronic address:

Arsenic trioxide (AsO), a front-line therapeutic agent against acute promyelocytic leukemia, has a broad spectrum against malignancies. Unfortunately, the clinical application of AsO in treating hematological cancers has not been transformed to solid tumors, for its dose-limited toxicity and undesirable pharmacokinetics. The ordinary AsO loaded nanodrugs (such as liposomes, polymer micelles, albumin-based nanodrugs, and silica-based nanodrugs, etc.) still could not fuel up pharmaceuticals and eradicate toxicity for low delivery efficiency caused by the instability and severe drug leakage of formulations during circulation. Recently, the approach of forming and delivering arsenic-metal complexes which will dissociate in the tumoral environment caught our mind. This is the most effective strategy to reduce drug leakage in circulation and accumulate arsenite ions in tumor sites, therefore promote the anti-tumor effect and lighten the toxicity of the drug. This review aims to explain the formation mechanism of arsenic-metal nanocomposites and summarize the constructing strategies of the arsenic-metal nanocomplexes (arsenic-nickel, arsenic-manganese, arsenic-platinum, arsenic-gadolinium, arsenic-zinc, and arsenic-iron nanobins) loaded nanodrugs for solid tumor therapy. Furthermore, the expectations and challenges of arsenic-metal complexes containing nanodrugs for cancer therapy in the future were discussed.
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http://dx.doi.org/10.1016/j.ijpharm.2020.119385DOI Listing
June 2020

The 16-year experience in treating low-risk gestational trophoblastic neoplasia patients with failed primary methotrexate chemotherapy.

J Gynecol Oncol 2020 Jul 7;31(4):e36. Epub 2020 Jan 7.

Department of Gynecologic Oncology, Women's Hospital, School of Medicine Zhejiang University, Hangzhou, China.

Objective: To assess the outcomes and toxic effects of 5-day actinomycin D (Act-D) salvage therapy and to explore the predictors of Act-D resistance in patients with low-risk gestational trophoblastic neoplasia (GTN)who failed 5-day methotrexate (MTX) chemotherapy.

Methods: This retrospective study analyzed patients with low-risk GTN administered Act-D salvage therapy after failing MTX chemotherapy at Women's Hospital, School of Medicine Zhejiang University between January 2000 and December 2015. The clinical parameters of these patients were collected and analyzed.

Results: The final analysis included 89 cases. Of these, 73 cases (82.02%) responded to salvage Act-D. The remaining 16 resistant cases were switched to etoposide, MTX, Act-D/cyclophosphamide, and vincristine chemotherapy and achieved complete remission. Serum human chorionic gonadotrophin levels before Act-D salvage therapy (hCG)in the Act-D-resistant cases were significantly higher than those in the Act-D responders (median 605 vs. 103 IU/L, p=0.009). However, the range of hCG values in Act-D responders was wider than that in Act-D-resistant cases (5.76-16,664 IU/L vs. 11.43-6,732 IU/L). Thus, assigning a general cut-off value was difficult considering the individual setting. Except for 2 cases requiring other salvage regimens due to Act-D toxicity, 97.80% of cases (89/91) tolerated the toxicity. During at least 1-year follow-up, the survival rate was 100.00% and no case developed recurrence.

Conclusion: Based on the good therapeutic effect and tolerable toxicity, we recommend Act-D salvage therapy for all patients with low-risk GTN who fail primary MTX chemotherapy. The higher serum hCG levels before Act-D salvage therapy may be associated with resistance to this treatment.
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http://dx.doi.org/10.3802/jgo.2020.31.e36DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286751PMC
July 2020

Effects of high-shear mixing and the graphene oxide weight fraction on the electrochemical properties of the GO/Ni(OH) electrode.

Dalton Trans 2020 Feb;49(6):1752-1764

School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, China.

A high-shear mixer was used in the process of chemical precipitation to prepare graphene oxide (GO) and Ni(OH)2 composites with different weight fractions of GO from 0 wt% to 2.6 wt%. The GO/Ni(OH)2 composite with 1.5 wt% GO prepared by high-shear mixing (1.5GO/Ni(OH)2-H) displayed a high specific capacitance (1836 F g-1 at 2 mV s-1), which was beyond that (1581 F g-1 at 2 mV s-1) of GO/Ni(OH)2 obtained by impeller agitator stirring (1.5GO/Ni(OH)2-M). 1.5GO/Ni(OH)2-H also showed excellent cycling stability, retaining 91.7% of its initial specific capacitance after 2000 cycles. Furthermore, the asymmetric device (the 1.5GO/Ni(OH)2-H as the positive electrode and active carbon as the negative electrode) exhibited a high energy density of 41.2 W h kg-1 at a power density of 1500 W kg-1 with a voltage of 1.5 V. In addition, the effects of high-shear mixing and impeller agitator stirring on the microstructures and electrochemical properties of the composites were discussed, which indicated that high-shear mixing could exfoliate graphene oxide and restrain the grain growth of Ni(OH)2, thus leading to excellent electrochemical performance.
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http://dx.doi.org/10.1039/c9dt04525bDOI Listing
February 2020

Defects and Aliovalent Doping Engineering in Electroceramics.

Chem Rev 2020 Feb 3;120(3):1710-1787. Epub 2020 Jan 3.

State Key Laboratory of Advanced Welding and Joining , Harbin Institute of Technology , Harbin 150001 , P. R. China.

Since the positive influences of defects on the performance of electroceramics were discovered, investigations concerning on defects and aliovalent doping routes have grown rapidly in the fields of inorganic chemistry and condensed matter physics. In this article, we summarized the types of defects in electroceramics as well as characterization tools of defects and highlighted the effects of intrinsic and extrinsic defects on the material performances with the emphasis on dielectric, ferroelectric, and piezoelectric properties. We mainly introduced defect related theoretical simulation and experimental results in several typical incipient ferroelectrics, ferroelectrics, and antiferroelectrics. Hence, the influences of defects on the crystal lattice were summed up, and then the main physical mechanisms were highlighted. Particularly, the performance enhancements of aliovalently doped electroceramics were also evaluated and reviewed. Finally, the outlook and challenges were discussed on the basis of their current developments. This article covers not only an overview of the state-of-the-art advances of defects and aliovalent doping routes in electroceramics but also the future prospects that may open another window to tune the electrical performance of electroceramics via intentionally introducing certain defects.
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http://dx.doi.org/10.1021/acs.chemrev.9b00507DOI Listing
February 2020

Mannose-Modified PLGA Nanoparticles for Sustained and Targeted Delivery in Hepatitis B Virus Immunoprophylaxis.

AAPS PharmSciTech 2019 Dec 5;21(1):13. Epub 2019 Dec 5.

Women's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China.

The launched hepatitis B vaccine could induce powerful antibodies, whereas it failed to improve potent cellular immune responses due to that the Th2-type response-induced aluminum adjuvant was adopted. Here, to target antigen-presenting cells under the epidermis and induce potent cellular and humoral immune responses, mannose-modified poly D,L-lactide-co-glycolic acid (PLGA) was synthesized and nanoparticle (MNP)-loaded hepatitis B surface antigen (HBsAg) protein was prepared. HBsAg could be slowly released and highly presented to lymphocytes which facilitated to produce long-lasting immunity based on characters of PLGA. In vitro uptake test results showed that MNPs could enhance internalization in bone marrow-derived dendritic cells (BMDCs) and RAW 264.7 cells. Subcutaneous delivery of MNPs into mice kept humoral immune and strengthened cellular immune responses. Experimental results indicated that MNPs showed significantly modified properties compared with parental PLGA nanoparticles. Thus, the obtained MNPs could be a promising vehicle for hepatitis B vaccine delivery.
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http://dx.doi.org/10.1208/s12249-019-1526-5DOI Listing
December 2019

A free-standing manganese cobalt [email protected] nickel layered double hydroxide core-shell heterostructure for an asymmetric supercapacitor.

Dalton Trans 2020 Jan 6;49(1):196-202. Epub 2019 Dec 6.

State Key Laboratory of Advanced Welding and Joining, Harbin Institute of Technology, Harbin 150001, China.

Rational design of self-supported electrode materials is important to develop high-performance supercapacitors. Herein, a free-standing [email protected] LDH ([email protected] LDH) core-shell heterostructure is successfully prepared on Ni foam using the hydrothermal reaction and electrodeposition. In this architecture, the inner MnCoS nanotube provides an ultra-high electrical conductivity and the CoNi LDH nanosheets can offer more electrochemical active sites for better faradaic reactions. Moreover, the core-shell heterostructure can also maintain the structural integrity during the processes of continuous charge/discharge. The [email protected] LDH electrode displays a satisfactory specific capacitance of 1206 C g and excellent cycling performance with ∼92% retention after 10 000 cycles. In addition, an asymmetric supercapacitor (ASC), in which [email protected] LDH and N-doped rGO are used as the positive electrode and the negative electrode, was assembled which exhibits an energy density of 48.8 W h kg with superior cycling stability, indicating the potential of this electrode in practical energy storage.
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http://dx.doi.org/10.1039/c9dt03974kDOI Listing
January 2020

Dual GSH-exhausting sorafenib loaded manganese-silica nanodrugs for inducing the ferroptosis of hepatocellular carcinoma cells.

Int J Pharm 2019 Dec 31;572:118782. Epub 2019 Oct 31.

Department of Pharmacy, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China. Electronic address:

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths. Unfortunately, there is still no completely effective treatment. Ferroptosis could affect the development of HCC by regulating the level of glutathione (GSH), intracellular lipid peroxidation, and other related substances. This paper introduced a new one-pot reaction for the synthesis of manganese doped mesoporous silica nanoparticles (manganese-silica nanoparticles, MMSNs) which could induce ferroptosis of the tumor cells through the consumption of intracellular GSH caused by the degradation of MMSNs. The more amount of MnCl added during the preparation, the larger doping amount of manganese presented in MMSNs. When the molar ratio of TEOS to MnCl was 5:1, the prepared MMSNs had a small size (102.6 ± 3.06 nm), uniform structure (pore sizes of 3.67 nm) and large pore volume. Manganese-oxidation bonds of MMSNs could break in high GSH concentration, which in turn consume GSH in the environment rapidly. Sorafenib (SO), an inhibitor of X transport system was loaded in the MMSNs ([email protected]) with a drug loading rate of 2.68 ± 0.32%. [email protected] achieved on-demand drug release in the tumor microenvironment due to the degradation of MMSNs. Subsequently, a significant tumor cell (HepG2) suppression effect of [email protected] was achieved through the consumption of GSH and synthesis inhibition of intracellular GSH. The depletion of GSH led to the inactivity of glutathione peroxidase 4 and increase of intracellular lipid peroxide, which could induce the ferroptosis of HCC cells. In summary, such dual GSH-exhausting nanodrugs have a great potential to induce ferroptosis of HCC cells.
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http://dx.doi.org/10.1016/j.ijpharm.2019.118782DOI Listing
December 2019

In situ synthesis of core-shell vanadium [email protected] carbon microsheet sponges as high-performance anode materials for solid-state supercapacitors.

J Colloid Interface Sci 2020 Feb 18;560:122-129. Epub 2019 Oct 18.

State Key Laboratory of Advanced Welding and Joining, Harbin Institute of Technology, Harbin 150001, China.

Vanadium nitride (VN) with high conductivity exhibits the potential promising as anode materials for supercapacitors, but VN suffered the obvious performance fading due to the dissolution of VN in aqueous electrolyte. In this work, we solve these problems through realizing 3D structural VN microsheets shelled with N-doped carbon layer ([email protected]) by introducing melamine as nitrogen source and PVP as carbon source. The as-prepared [email protected] electrode display high capacitance of 368 F g and good rate property. A solid-state asymmetric supercapacitor (ASC) with NiCoO nanowires as cathode materials and [email protected] as anode materials was fabricated. The ASC device exhibits the high energy density of 65.3 W h kg, and good cycling stability (92% capacitance retention) after 4000 cycles. Moreover, the ASC device shows good mechanical flexibility with negligible capacitance loss after 1000 bending cycles.
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http://dx.doi.org/10.1016/j.jcis.2019.10.061DOI Listing
February 2020

Perovskite Sr(NaBi)TiMnO Thin Films with Defect Dipoles for High Energy-Storage and Electrocaloric Performance.

ACS Appl Mater Interfaces 2019 Oct 3;11(41):37947-37954. Epub 2019 Oct 3.

Dielectric capacitors have received more and more attention because of fast charge/discharge capability. However, the energy-storage performance still cannot meet the demand. In this work, lead-free perovskite Sr(NaBi)TiMnO ( = 0, 0.005, 0.01, and 0.02) thin films prepared by the sol-gel method were carefully studied. Defect dipoles and local lattice distortion were created by doping Mn at the B-site, enabling ferroelectric polarization behavior. To further enhance polarization, co-substitution at the A-site was adopted. Na and Bi can make up Na-Bi ion pairs. Meanwhile, off-center Na and Bi ions with a small radius can lead to the distortion of the octahedral [TiO] in the lattice to induce local polarization regions. Under the combined action of A-site and B-site doping, polarization and breakdown strength were greatly improved. Finally, a high energy density (53 J cm) and good thermal stability were achieved. Furthermore, the negative electrocaloric effect was also achieved. The adiabatic temperature change is about -8.5 at 300 K. This work demonstrates that the Sr(NaBi)(TiMn)O thin film with excellent energy-storage performance and the negative electrocaloric effect is a promising multifunctional material.
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http://dx.doi.org/10.1021/acsami.9b14815DOI Listing
October 2019

Defect-Rich Heterogeneous MoS/NiS Nanosheets Electrocatalysts for Efficient Overall Water Splitting.

Adv Sci (Weinh) 2019 Jul 20;6(14):1900246. Epub 2019 May 20.

School of Materials Science and Engineering Harbin Institute of Technology Harbin 150001 China.

Designing and constructing bifunctional electrocatalysts is vital for water splitting. Particularly, the rational interface engineering can effectively modify the active sites and promote the electronic transfer, leading to the improved splitting efficiency. Herein, free-standing and defect-rich heterogeneous MoS/NiS nanosheets for overall water splitting are designed. The abundant heterogeneous interfaces in MoS/NiS can not only provide rich electroactive sites but also facilitate the electron transfer, which further cooperate synergistically toward electrocatalytic reactions. Consequently, the optimal MoS/NiS nanosheets show the enhanced electrocatalytic performances as bifunctional electrocatalysts for overall water splitting. This study may open up a new route for rationally constructing heterogeneous interfaces to maximize their electrochemical performances, which may help to accelerate the development of nonprecious electrocatalysts for overall water splitting.
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http://dx.doi.org/10.1002/advs.201900246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661938PMC
July 2019

High energy-storage density of lead-free (SrBi)TiMnO thin films induced by Bi-V dipolar defects.

Phys Chem Chem Phys 2019 Jul;21(29):16359-16366

School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, People's Republic of China. and State Key Laboratory of Advanced Welding and Joining, Harbin Institute of Technology, Harbin 150001, P. R. China.

Capacitors with high energy storage density, low cost, ultrafast charge-discharge capability, and environmental friendliness are in high demand for application in new energy vehicles, modern electrical systems, and high-energy laser weapons. Here, lead-free (Sr1-1.5xBix)Ti0.99Mn0.01O3 (x = 0.01, 0.05, 0.1) thin films grown on Pt/Ti/SiO2/Si substrates were obtained by a sol-gel method. All the thin films have a relatively high dielectric breakdown strength (BDS) due to the added 1% Mn and pinched polarization hysteresis loops can be observed in 5 and 10 mol% Bi-doped SrTiO3 thin films. The ferroelectric behaviors of the Bi-doped SrTiO3 thin films come from the rotation of the TiO6-octahedra induced by the formation of Bi3+-VSr dipolar defects. With the increase of doping concentration, the Pmax-Pr values of the Bi-doped SrTiO3 thin films increased dramatically and can reach 34.3 μC cm-2 upon doping with 10 mol% Bi. A high recoverable energy-storage density of 24.4 J cm-3 with excellent temperature stability was obtained for the 10 mol% Bi-doped ST thin film, which shows that the (Sr0.85Bi0.1)Ti0.99Mn0.01O3 thin film is a promising candidate for high-power energy storage applications. This finding demonstrates an improved energy density of SrTiO3-based thin film systems and a reasonable explanation for the source of the ferroelectricity based on first-principles calculations is given.
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http://dx.doi.org/10.1039/c9cp01368gDOI Listing
July 2019

Oxygen-vacancy-rich nickel-cobalt layered double hydroxide electrode for high-performance supercapacitors.

J Colloid Interface Sci 2019 Oct 29;554:59-65. Epub 2019 Jun 29.

State Key Laboratory of Advanced Welding and Joining, Harbin Institute of Technology, Harbin 150001, China.

The introduction of oxygen vacancies into electrode materials has been proven to be a valid way to enhance the electrochemical performance. However, the traditional methods to introduce oxygen vacancies require severe conditions that may be harmful to hydroxides. Herein, the oxygen vacancy-rich nickel-cobalt (NiCo) layered double hydroxide (denoted as V-NiCo LDH) nanowire array electrode is synthesized using the chemical reduction method. Owing to the reduction of NaBH solution, we can create oxygen vacancies under milder conditions, thus avoiding any damage to the hydroxide. The as-synthesized electrode shows a specific capacitance of 1563.1 F g at 1 A g, which is much higher than that of the pristine electrode (995.4 F g at 1 A g). Moreover, the cycling performance and rate performance are also enhanced. The as-fabricated asymmetric supercapacitor (V-NiCo LDH//FeO) is able to deliver a maximum energy density of 56.2 W h kg at a power density of 800 W kg with a voltage window of 1.6 V.
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http://dx.doi.org/10.1016/j.jcis.2019.06.095DOI Listing
October 2019

Free-standing porous NiP-NiP heterostructured arrays for efficient electrocatalytic water splitting.

J Colloid Interface Sci 2019 Sep 21;552:332-336. Epub 2019 May 21.

State Key Laboratory of Advanced Welding and Joining, Harbin Institute of Technology, Harbin 150001, China.

Constructing heterointerfaces in heterostructures could effectively enlarge the electroactive sites and enhance the interfacial charge transfer, and thus improve the electrocatalytic performances. Herein, free-standing porous NiP-NiP heterostructured arrays are successfully prepared through in situ phosphating Ni(OH) arrays by simply tuning the reaction temperatures. Contributing from the interfacial coupling effects of two phases, large surface areas, highly conductive support of carbon cloth substrates and unique free-standing arrays, NiP-NiP heterostructured arrays show the enhanced kinetics and electrocatalytic performances for the hydrogen evolution reaction, oxygen evolution reaction and overall water splitting. Our research might offer insight into constructing heterophase junctions for efficient overall water splitting.
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http://dx.doi.org/10.1016/j.jcis.2019.05.064DOI Listing
September 2019

"One-for-All" strategy to design oxygen-deficient triple-shelled MnO and hollow FeO microcubes for high energy density asymmetric supercapacitors.

Dalton Trans 2019 Jun 20;48(24):8623-8632. Epub 2019 May 20.

College of Materials Science and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China.

Intrinsically poor conductivity, sluggish ion transfer kinetics, and limited specific area are the three main obstacles that confine the electrochemical performance of metal oxides in supercapacitors. Engineered hollow metal oxide nanostructures can effectively satisfy the increasing power demand of modern electronics. In this work, both triple-shelled MnO and hollow FeO microcubes have been synthesized from a single MnCO template. The oxygen vacancies are introduced in both the positive and negative electrodes through a facile method. The oxygen vacancies can not only improve the conductivity and facilitate ion diffusion but also increase the electrode/electrolyte interfaces and electrochemically active sites. Consequently, both the oxygen-deficient triple-shelled MnO and hollow FeO exhibit larger capacitance and rate capability than the samples without oxygen vacancies. Moreover, due to the matchable specific capacitance and potential window between the positive and negative electrodes, the asymmetric supercapacitor exhibits high specific capacitance (240 F g), excellent energy density of 133 W h kg at 1176 W kg, excellent power density (23 529 W kg at 73 W h kg), and high cycling stability (90.9% after 5000 cycles). This strategy is highly reproducible in oxide-based electrodes, which have the potential to meet the requirements of practical application.
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http://dx.doi.org/10.1039/c9dt01682aDOI Listing
June 2019

Angiopep-2-Conjugated "Core-Shell" Hybrid Nanovehicles for Targeted and pH-Triggered Delivery of Arsenic Trioxide into Glioma.

Mol Pharm 2019 02 24;16(2):786-797. Epub 2019 Jan 24.

College of Pharmaceutical Science , Zhejiang Chinese Medical University , Hangzhou 311402 , China.

The poor capability of drugs to permeate through the blood-brain barrier (BBB) and further release inside glioma greatly limits the curative effects of glioma chemotherapies. In this study, we prepared angiopep-2-conjugated liposome-silica hybrid nanovehicles for targeted delivery and increased the permeation of arsenic trioxide (ATO) in glioma. Polyacrylic acid (PAA) was grafted on mesoporous silica nanoparticles (MSN) for pH-sensitive release and supporting the lipid membrane. The prepared "core-shell" nanovehicles (ANG-LP-PAA-MSN) were characterized with uniform size, high drug loading efficiency (8.19 ± 0.51%), and superior pH-sensitive release feature. From the experiments, the enhanced targeted delivery of ATO by ANG-LP-PAA-MSN ([email protected]) was evidenced by the improvement of transport, enhanced cellular uptake, and apoptosis in vitro. In addition, the pharmacokinetic study was creatively carried out through the blood-glioma synchronous microdialysis and revealed that the half-life ( t) of blood and glioma tissue in the [email protected] treatment group was extended by 1.65 and 2.34 times compared with the ATO solution group (ATO-Sol). The targeting efficiency of [email protected] (24.96%) was dramatically stronger than that of the ATO-Sol (5.94%). Importantly, [email protected] had a higher accumulation (4.6 ± 2.6% ID per g) in tumor tissues and showed a better therapeutic efficacy in intracranial C6 glioma bearing rats. Taken together, the blood-glioma synchronous microdialysis was successful used for the pharmacokinetic study and real-time monitoring of drug concentrations in blood and glioma; ANG-LP-PAA-MSN could be a promising targeted drug delivery system for glioma therapy.
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http://dx.doi.org/10.1021/acs.molpharmaceut.8b01056DOI Listing
February 2019

Designing and constructing core-shell [email protected] on Ni foam by facile one-step strategy as advanced battery-type electrodes for supercapattery.

J Colloid Interface Sci 2019 Feb 25;536:456-462. Epub 2018 Oct 25.

State Key Laboratory of Advanced Welding and Joining, Harbin Institute of Technology, Harbin 150001, China.

Herein, we successfully design and construct core-shell nanostructured [email protected] directly on Ni foam by a scalable and effective one-step strategy. Further, through simply and accurately controlling the concentration of sulfur source, various nanostructures of [email protected] arrays in situ on Ni foam are successfully synthesized. The intriguing core-shell structures and integrated electrode configurations endow [email protected] electrode a large electroactive sites, fast electron transport path and sufficient contacts with electrolyte. Serving as free-standing electrode, as-fabricated [email protected] arrays exhibit the high specific capacity (4.55 C cm at 5 mA cm), good rate performance and good cycling stability. Impressively, current research provides a general, scalable and effective one-step strategy for constructing core-shell nanostructures for energy storage devices.
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http://dx.doi.org/10.1016/j.jcis.2018.10.072DOI Listing
February 2019

Mesostructured Carbon Nanotube-on-MnO Nanosheet Composite for High-Performance Supercapacitors.

ACS Appl Mater Interfaces 2018 Nov 5;10(45):38963-38969. Epub 2018 Nov 5.

State Key Laboratory of Advanced Welding and Joining , Harbin Institute of Technology , Harbin 150001 , China.

Carbon nanomaterials have been widely used to enhance the performance of MnO-based supercapacitors. However, it still remains a challenge to directly fabricate high combining strength, mesostructured and high-performance MnO/carbon nanotube (CNT)-nanostructured composite electrodes with a little weight percentage of carbon materials. Here, we report a novel mesostructured composite of the CNT-on-MnO nanosheet with a high MnO percentage, which consists of vertically aligned MnO nanosheets with nanopores and in situ formed oriented CNTs on MnO nanosheets (tube-on-sheet). The optimized CNTs/MnO possesses favorable features, namely, vertically aligned nanosheets to shorted ion diffusion path, a hierarchical porous structure for increased specific surface areas and active sites, and in situ formed CNTs for enhanced conductivity and robust structural stability. It is found that the unique tube-on-sheet CNTs/MnO nanocomposites with the high MnO percentage (>90 wt %) exhibit a high specific capacity of 1131 F g based on total electrodes and 1229 F g based on MnO at a current density of 1 A g, high rate capability, and ultrastable cycling life (94.4%@10 000 cycles). This electrode design strategy in this paper demonstrates a new way for high-performance electrodes for supercapacitors with high active material percentage.
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http://dx.doi.org/10.1021/acsami.8b14109DOI Listing
November 2018

High strength and ductility of graphene-like carbon nanosheet/copper composites fabricated directly from commercial oleic acid coated copper powders.

Nanoscale 2018 Sep;10(36):16990-16995

State Key Laboratory of Advanced Welding and Joining, Harbin Institute of Technology, Harbin, 150001, China.

Recently, copper matrix composites reinforced with graphene or graphene-like carbon nanosheets (GNS) have attracted great attention due to their excellent properties. However, the fabrication technologies of the composites are generally complex and expensive; it is necessary to develop facile and cheap synthesis methods for industrial applications of the composites with high performance. Here, we present a very simple method to fabricate GNS reinforced copper composites: commercial Cu powders with oleic acid coating are directly fabricated into GNS/Cu composites by spark plasma sintering. This work provides a facile method with low cost and high efficiency for the preparation of GNS reinforced metal matrix composites with high performance, which opens a new window for the large-scale production of graphene based composites.
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http://dx.doi.org/10.1039/c8nr04451aDOI Listing
September 2018