Wei-Ping Gai

Wei-Ping Gai

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Wei-Ping Gai

Wei-Ping Gai

Publications by authors named "Wei-Ping Gai"

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52Publications

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Axonal dystrophy in the brain of mice with Sanfilippo syndrome.

Exp Neurol 2017 09 8;295:243-255. Epub 2017 Jun 8.

Lysosomal Diseases Research Unit, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA 5001, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.expneurol.2017.06.010DOI Listing
September 2017

Neuroprotective Activities of Marine Natural Products from Marine Sponges.

Curr Med Chem 2016 ;23(4):360-82

Department of Medical Biotechnology, School of Medicine, Flinders University, Adelaide 5001, South Australia, Australia.

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http://dx.doi.org/10.2174/0929867323666151127201249DOI Listing
October 2016

Interference of α-Synuclein Uptake by Monomeric β-Amyloid1-40 and Potential Core Acting Site of the Interference.

Neurotox Res 2016 10 30;30(3):479-85. Epub 2016 Jun 30.

Department of Surgery and Centre for Neuroscience, School of Medicine, Flinders University, Bedford Park, SA, 5042, Australia.

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http://dx.doi.org/10.1007/s12640-016-9644-2DOI Listing
October 2016

Caspase-1 causes truncation and aggregation of the Parkinson's disease-associated protein α-synuclein.

Proc Natl Acad Sci U S A 2016 08 1;113(34):9587-92. Epub 2016 Aug 1.

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202; Department of Neurology, Indiana University School of Medicine, Indianapolis, IN 46202

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http://dx.doi.org/10.1073/pnas.1610099113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003239PMC
August 2016

Quantitative protein profiling of hippocampus during human aging.

Neurobiol Aging 2016 Mar 8;39:46-56. Epub 2015 Dec 8.

Department of Human Anatomy, Histology and Embryology, Institute of Basic Medical Sciences, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2015.11.029DOI Listing
March 2016

Identification of synaptosomal proteins binding to monomeric and oligomeric α-synuclein.

PLoS One 2015 6;10(2):e0116473. Epub 2015 Feb 6.

University of Aarhus, DANDRITE-Danish Research Institute of Translational Neuroscience & Department of Biomedicine, Aarhus, Denmark.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0116473PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319895PMC
January 2016

Aggregation-induced emission fluorogens as biomarkers to assess the viability of microalgae in aquatic ecosystems.

Chem Commun (Camb) 2015 Dec;51(97):17257-60

Centre for NanoScale Science and Technology, School of Computer Science, Engineering and Mathematics, Flinders University, Adelaide 5042, Australia.

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http://dx.doi.org/10.1039/c5cc07012kDOI Listing
December 2015

Generation and characterization of novel conformation-specific monoclonal antibodies for α-synuclein pathology.

Neurobiol Dis 2015 Jul 30;79:81-99. Epub 2015 Apr 30.

Department of Biochemistry, College of Medicine and Health Science, United Arab Emirates University, Al Ain, United Arab Emirates; College of Science, Engineering and Technology, HBKU, Education City, Qatar Foundation, Doha, Qatar. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2015.04.009DOI Listing
July 2015

Non-neuronal and neuronal BACE1 elevation in association with angiopathic and leptomeningeal β-amyloid deposition in the human brain.

BMC Neurol 2015 May 2;15:71. Epub 2015 May 2.

Department of Anatomy and Neurobiology, Central South University School of Basic Medical Science, Changsha, Hunan, 410013, China.

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http://dx.doi.org/10.1186/s12883-015-0327-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428107PMC
May 2015

Dipeptidyl peptidase 10 (DPP10(789)): a voltage gated potassium channel associated protein is abnormally expressed in Alzheimer's and other neurodegenerative diseases.

Biomed Res Int 2014 16;2014:209398. Epub 2014 Jun 16.

School of Biological Sciences, Flinders University, GPO Box 2100, Adelaide, SA 5001, Australia.

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http://dx.doi.org/10.1155/2014/209398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084682PMC
March 2015

Detection of oligomers and fibrils of α-synuclein by AIEgen with strong fluorescence.

Chem Commun (Camb) 2015 Feb;51(10):1866-9

HKUST Shenzhen Research Institute, No. 9 Yuexing 1st RD, South Area, Hi-tech Park Nanshan, Shenzhen 518057, China.

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http://dx.doi.org/10.1039/c4cc07911fDOI Listing
February 2015

Brain banking as a cornerstone of neuroscience in China.

Lancet Neurol 2015 Feb;14(2):136

Department of Human Physiology and Centre for Neuroscience, Flinders University School of Medicine, Bedford Park, SA, Australia.

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http://dx.doi.org/10.1016/S1474-4422(14)70259-5DOI Listing
February 2015

Can BACE1 inhibition mitigate early axonal pathology in neurological diseases?

J Alzheimers Dis 2014 ;38(4):705-18

Department of Anatomy and Neurobiology, Central South University Xiangya School of Medicine, Changsha, Hunan, China.

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http://dx.doi.org/10.3233/JAD-131400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995167PMC
August 2014

Evidence that the LRRK2 ROC domain Parkinson's disease-associated mutants A1442P and R1441C exhibit increased intracellular degradation.

J Neurosci Res 2014 Apr 24;92(4):506-16. Epub 2013 Dec 24.

Centre for Neuromuscular and Neurological Disorders, The University of Western Australia, Australian Neuro-Muscular Research Institute, Nedlands, Western Australia, Australia.

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http://dx.doi.org/10.1002/jnr.23331DOI Listing
April 2014

Alpha-synuclein transmission and mitochondrial toxicity in primary human foetal enteric neurons in vitro.

Neurotox Res 2014 Feb 12;25(2):170-82. Epub 2013 Sep 12.

Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, NSW, Australia,

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http://dx.doi.org/10.1007/s12640-013-9420-5DOI Listing
February 2014

Amyloid beta₁₋₄₂ (Aβ₄₂) up-regulates the expression of sortilin via the p75(NTR)/RhoA signaling pathway.

J Neurochem 2013 Oct 22;127(2):152-62. Epub 2013 Aug 22.

School of Pharmacy and Medical Sciences, Faculty of Health Sciences, University of South Australia, Adelaide, SA, Australia; Department of Human Physiology, Centre for Neuroscience, University of Flinders, Adelaide, SA, Australia.

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http://dx.doi.org/10.1111/jnc.12383DOI Listing
October 2013

Tenuigenin attenuates α-synuclein-induced cytotoxicity by down-regulating polo-like kinase 3.

CNS Neurosci Ther 2013 Sep 27;19(9):688-94. Epub 2013 May 27.

Department of Neurobiology, Key Laboratory for Neurodegenerative Disorders of the Ministry of Education, Capital Medical University, Beijing, China.

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http://dx.doi.org/10.1111/cns.12124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6493467PMC
September 2013

Selective coexpression of synaptic proteins, α-synuclein, cysteine string protein-α, synaptophysin, synaptotagmin-1, and synaptobrevin-2 in vesicular acetylcholine transporter-immunoreactive axons in the guinea pig ileum.

J Comp Neurol 2013 Aug;521(11):2523-37

Department of Human Physiology and Centre for Neuroscience, Flinders Medical Science and Technology, School of Medicine, Flinders University, Bedford Park, South Australia 5042, Australia.

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http://dx.doi.org/10.1002/cne.23296DOI Listing
August 2013

LRRK2 interactions with α-synuclein in Parkinson's disease brains and in cell models.

J Mol Med (Berl) 2013 Apr 27;91(4):513-22. Epub 2012 Nov 27.

Cell and Molecular Neuroscience Unit, Instituto de Medicina Molecular, Lisbon 04250, Portugal.

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http://dx.doi.org/10.1007/s00109-012-0984-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3611031PMC
April 2013

SUMO-1 is associated with a subset of lysosomes in glial protein aggregate diseases.

Neurotox Res 2013 Jan 15;23(1):1-21. Epub 2012 Nov 15.

School of Medical Science, Griffith Health Institute, Griffith University, Gold Coast Campus, Gold Coast, QLD 4222, Australia.

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http://dx.doi.org/10.1007/s12640-012-9358-zDOI Listing
January 2013

Transmission of Synucleinopathies in the Enteric Nervous System of A53T Alpha-Synuclein Transgenic Mice.

Exp Neurobiol 2011 Dec 29;20(4):181-8. Epub 2011 Dec 29.

Department of Anatomy, School of Medicine, Konkuk University, Seoul 143-701, Korea.

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http://dx.doi.org/10.5607/en.2011.20.4.181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268152PMC
December 2011

Changes in the solubility and phosphorylation of α-synuclein over the course of Parkinson's disease.

Acta Neuropathol 2011 Jun 13;121(6):695-704. Epub 2011 Mar 13.

Neuroscience Research Australia, The University of New South Wales, Sydney, Australia.

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http://dx.doi.org/10.1007/s00401-011-0815-1DOI Listing
June 2011

Alpha-synuclein aggregation and Ser-129 phosphorylation-dependent cell death in oligodendroglial cells.

J Biol Chem 2009 Apr 9;284(15):10211-22. Epub 2009 Feb 9.

Department of Medical Biochemistry, University of Aarhus, DK-8000 Aarhus, Denmark, Lundbeck A/S, DK-2500 Valby, Denmark.

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http://dx.doi.org/10.1074/jbc.M809671200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665075PMC
April 2009

Real-time analysis of amyloid fibril formation of alpha-synuclein using a fibrillation-state-specific fluorescent probe of JC-1.

Biochem J 2009 Mar;418(2):311-23

School of Chemical and Biological Engineering, College of Engineering, Seoul National University, Gwanak-Ku, Seoul 151-744, South Korea.

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http://biochemj.org/lookup/doi/10.1042/BJ20081572
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http://dx.doi.org/10.1042/BJ20081572DOI Listing
March 2009

NSF, Unc-18-1, dynamin-1 and HSP90 are inclusion body components in neuronal intranuclear inclusion disease identified by anti-SUMO-1-immunocapture.

Acta Neuropathol 2008 Dec 3;116(6):603-14. Epub 2008 Oct 3.

School of Medical Science, Griffith Institute of Health and Medical Research, Griffith University, Gold Coast Campus, Queensland, QLD, 4222, Australia.

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http://link.springer.com/10.1007/s00401-008-0437-4
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http://dx.doi.org/10.1007/s00401-008-0437-4DOI Listing
December 2008

LRRK2 and parkin immunoreactivity in multiple system atrophy inclusions.

Acta Neuropathol 2008 Dec 21;116(6):639-46. Epub 2008 Oct 21.

Prince of Wales Medical Research Institute, Barker Street, Randwick, NSW, 2031, Australia.

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http://dx.doi.org/10.1007/s00401-008-0446-3DOI Listing
December 2008

Proteomic analysis of Myrmecia pilosula (jack jumper) ant venom.

Toxicon 2006 Feb 27;47(2):208-17. Epub 2005 Dec 27.

Department of Pharmacy, Flinders Medical Centre, Flinders Drive, Bedford Park 5042, Australia.

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http://dx.doi.org/10.1016/j.toxicon.2005.10.018DOI Listing
February 2006

Molecular characterization of a novel dipeptidyl peptidase like 2-short form (DPL2-s) that is highly expressed in the brain and lacks dipeptidyl peptidase activity.

Biochim Biophys Acta 2006 Jan 28;1764(1):33-43. Epub 2005 Oct 28.

School of Biological Sciences, Flinders University, GPO BOX 2100, Adelaide, South Australia 5001, Australia.

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http://linkinghub.elsevier.com/retrieve/pii/S157096390500342
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http://dx.doi.org/10.1016/j.bbapap.2005.09.013DOI Listing
January 2006

Phosphorylated IkappaBalpha is a component of Lewy body of Parkinson's disease.

Biochem Biophys Res Commun 2005 May;331(1):309-17

Department of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2005.03.167DOI Listing
May 2005

Annular alpha-synuclein oligomers are potentially toxic agents in alpha-synucleinopathy. Hypothesis.

Neurotox Res 2005 ;7(1-2):59-67

Department of Human Physiology and School of Chemistry, Physics and Earth Sciences, Flinders University, Bedford Park SA 5042, Australia.

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April 2005

Insoluble alpha-synuclein in Alzheimer's disease without Lewy body formation.

Neurotox Res 2005 ;7(1-2):69-76

Prince of Wales Medical Research Institute, Sydney, 2031 Australia.

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April 2005

p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies.

J Biol Chem 2005 Feb 7;280(7):5703-15. Epub 2004 Dec 7.

Institute of Medical Biochemistry and Stereological Research and Electron Microscopy Laboratory, University of Aarhus, Aarhus, DK-8000, Denmark.

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http://dx.doi.org/10.1074/jbc.M410409200DOI Listing
February 2005

Calcium(II) selectively induces alpha-synuclein annular oligomers via interaction with the C-terminal domain.

Protein Sci 2004 Dec 10;13(12):3245-52. Epub 2004 Nov 10.

School of Chemistry, Physics and Earth Sciences, Flinders University, Bedford Park, SA 5042, Australia.

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http://dx.doi.org/10.1110/ps.04879704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2287302PMC
December 2004

alpha-Synuclein filaments bind the transcriptional regulator HMGB-1.

Neuroreport 2004 Dec;15(18):2735-9

Department of Medical Biochemistry, University of Aarhus, DK-8000 Aarhus C, Denmark.

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December 2004

Septin 3 (G-septin) is a developmentally regulated phosphoprotein enriched in presynaptic nerve terminals.

J Neurochem 2004 Nov;91(3):579-90

Cell Signalling Unit, Children's Medical Research Institute, New South Wales 2145, Australia.

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http://dx.doi.org/10.1111/j.1471-4159.2004.02755.xDOI Listing
November 2004

Dominantly-inherited adult-onset leukodystrophy with palatal tremor caused by a mutation in the glial fibrillary acidic protein gene.

Mov Disord 2004 Oct;19(10):1244-8

Department of Neurology, Flinders Medical Centre and Flinders University, South Australia, Australia.

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http://dx.doi.org/10.1002/mds.20161DOI Listing
October 2004

Annular alpha-synuclein species from purified multiple system atrophy inclusions.

J Neurochem 2004 Jul;90(2):502-12

Department of Human Physiology, Flinders University, Adelaide, Australia.

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http://dx.doi.org/10.1111/j.1471-4159.2004.02533.xDOI Listing
July 2004

Alpha-synuclein expression localizes to the Golgi apparatus in bovine adrenal medullary chromaffin cells.

Brain Res 2003 Sep;984(1-2):233-6

Department of Anatomy and Structural Biology, School of Medical Sciences, University of Otago, P.O. Box 913, Dunedin, New Zealand.

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http://dx.doi.org/10.1016/s0006-8993(03)03040-3DOI Listing
September 2003

Nonselenium glutathione peroxidase in human brain : elevated levels in Parkinson's disease and dementia with lewy bodies.

Am J Pathol 2002 Sep;161(3):885-94

Department of Human Physiology, School of Medicine, Flinders University, Bedford Park, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1867235PMC
http://dx.doi.org/10.1016/S0002-9440(10)64249-6DOI Listing
September 2002

Platelet alpha- and gamma-synucleins in Parkinson's disease and normal control subjects.

J Alzheimers Dis 2002 Aug;4(4):309-15

Department of Pathology, The University of Melbourne, and The Mental Health Research Institute of Victoria, Parkville, Vic 3010, Australia.

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August 2002