Publications by authors named "Wei-Guang Zhang"

103 Publications

[Clinical anatomical study on the treatment of tarsal tunnel syndrome with four-point vertical acupotomy].

Zhongguo Gu Shang 2022 Jun;35(6):543-7

Department of Acupuncture, China-Japan Friendship Hospital, Beijing 100029, China.

Objective: To explore safety and accuracy of four-point acupotomy for the treatment of tarsal tunnel syndrome regarding release of ankle tunnel flexor retinaculum to provide an anatomical basis of clinical treatment.

Methods: Twenty-nine adult specimens (15 males and 14 females) fixed with 10% formalin, aged from 47 to 98 years old with an average age of (81.10±11.14) years old, 29 on the right side and 29 on the left side, which were selected for the study from September 2020 to October 2020. Simulate the operation of loosening flexor retinaculumt with a needle knife on the human specimen, and place the specimen on the frog position of lower limbs with medial malleolus upward to determine the center of medial malleolus. Choose 4 different positions near the flexor retinaculum to insert the needle so that the needle body was perpendicular to skin and cutting edge direction was perpendicular to the running direction of the flexor retinaculum. The needle knife penetrates the skin and explores slowly. When the flexor retinaculum was reached, the needle tip may touch the tough tissue. At this time, the cutting is loosened for 4 times. After acupotomy release operation was completed, make a lateral incision on the skin surface along acupotomy direction, open the area of the exposed flexor retinaculum, dissecting layer by layer, observe and record the needle knife and its surrounding anatomical structure. The length of acupotomy cutting marks of flexor retinaculum was measured by electronic vernier caliper. The safety and accuracy of acupotomy loosening of ankle canal flexor retinaculum were evaluated by observing the number and degree of ankle canal contents such as tendons and nerves injured by needle knife. The safety is to count the number of cases of acupotomy injury to the contents of the ankle canal, and to calculate the injury rate, that is, the number of injury cases/total cases × 100%. The effective release was defined as the release length L ≥ W/2(W is the width of the flexor retinaculum, defined as 20 mm).

Results: For safety, there were no acupotomy injuries to nerves or blood vessels in 58 cases, 26 cases injuried to posterior tibial tendon which 17 of these tendon injury cases, the tendon was penetrated and severely injured, and flexor digitorum longus tendon was injured in 12 cases. Among these cases, tendon was penetrated and severely injured in 4 cases, and total injury rate was 32.14%. No nerve and vessel injury on c3 and c4 point. For accuracy, 58 specimens were successfully released. The length Lc of releasing trace for acupotomy was (10.40±1.36) cm, and length range 6.38 to 12.88 cm. Among all cases, the length of releasing trace was ≥10 mm in 37 cases. The overall success rate of release was 100.00%. Layered structure of ankle tube flexor retinaculumt:fiber diaphragm from flexor retinaculum divides contents of ankle tube into different chambers inward, and fiber diaphragm meets here to synthesize a complete flexor retinaculum at the midpoint of the line between the medial malleolus tip and calcaneal tubercle(above the neurovascular course).

Conclusion: Four-point needle-knife method of releasing flexor retinaculum for the treatment of tarsal tunnel syndrome is performed at the attachment of the two ends of flexor retinaculum;the tendon, but not the nerves and blood vessels, is easily damaged. It is safe to insert needle on the side of calcaneus. The extent of release is relatively complete, but due to the "layered" structure of the flexor retinaculum, classic surgical technique could only release one layer of flexor retinaculum when a needle is inserted at the edge of the bone and cannot achieve complete release of the full thickness of the flexor. Therefore, it remains to be determined whether the desired effect can be achieved clinically.
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http://dx.doi.org/10.12200/j.issn.1003-0034.2022.06.008DOI Listing
June 2022

Evaluation of Renal Impairment in Patients with Diabetic Kidney Disease by Integrated Chinese and Western Medicine.

Chin J Integr Med 2022 Jun 9. Epub 2022 Jun 9.

Department of Nephrology, First Medical Center of Chinese People's Liberation Army General Hospital, Nephrology Institute of the Chinese People's Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing, 100853, China.

Objective: To investigate the factors related to renal impairment in patients with diabetic kidney disease (DKD) from the perspective of integrated Chinese and Western medicine.

Methods: Totally 492 patients with DKD in 8 Chinese hospitals from October 2017 to July 2019 were included. According to Kidney Disease Improving Global Outcomes (KDIGO) staging guidelines, patients were divided into a chronic kidney disease (CKD) 1-3 group and a CKD 4-5 group. Clinical data were collected, and logistic regression was used to analyze the factors related to different CKD stages in DKD patients.

Results: Demographically, male was a factor related to increased CKD staging in patients with DKD (OR=3.100, P=0.002). In clinical characteristics, course of diabetes >60 months (OR=3.562, P=0.010), anemia (OR=4.176, P<0.001), hyperuricemia (OR=3.352, P<0.001), massive albuminuria (OR=4.058, P=0.002), atherosclerosis (OR=2.153, P=0.007) and blood deficiency syndrome (OR=1.945, P=0.020) were factors related to increased CKD staging in patients with DKD.

Conclusions: Male, course of diabetes >60 months, anemia, hyperuricemia, massive proteinuria, atherosclerosis, and blood deficiency syndrome might indicate more severe degree of renal function damage in patients with DKD. (Registration No. NCT03865914).
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http://dx.doi.org/10.1007/s11655-022-3520-0DOI Listing
June 2022

Enantioselective bioaccumulation, oxidative stress, and thyroid disruption assessment of cis-metconazole enantiomers in zebrafish (Danio rerio).

Aquat Toxicol 2022 Jul 22;248:106205. Epub 2022 May 22.

School of Chemistry, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, South China Normal University, Guangzhou 510006, China. Electronic address:

Chiral triazole pesticides may cause enantioselectively adverse effects to non-target organisms. In this work, we employed zebrafish as an aquatic organism model to explore stereoselective acute toxicity, bioaccumulation, oxidative stress, and thyroid disruption of cis-metconazole enantiomers. The median lethal concentration values of (1S, 5R)-metconazole, (1R, 5S)-metconazole, and the mixture of them against zebrafish were 4.01, 2.61 and 3.17 mg⋅L, respectively. (1R, 5S)-Metconazole was preferentially bioaccumulated in zebrafish than (1S, 5R)-metconazole, and the bioconcentration factor of (1R, 5S)-metconazole was 1.28-fold larger than that of (1S, 5R)-metconazole. Then, the activity order of catalase, superoxide dismutase, and glutathione-S transferase enzymes in zebrafish was expressed as (1S, 5R)-metconazole > the mixture > (1R, 5S)-metconazole, while the order of malondialdehyde content in zebrafish was (1R, 5S)-metconazole > the mixture > (1S, 5R)-metconazole. Moreover, cis-metconazole exhibited enantioselective regulation effects on the levels of triiodothyronine and thyroxine in zebrafish, and (1R, 5S)-metconazole possessed stronger thyroid disruption ability to zebrafish than the others. By virtue of molecular docking methodology, the binding affair and docking energy results supported that interactions between (1R, 5S)-metconazole and thyroid hormone receptors were much stronger than those between (1S, 5R)-metconazole and same receptors. This study of enantioselective evaluation of cis-metconazole in zebrafish can provide favorable information for risk assessments of chiral pesticides toward environment and health of aquatic organisms.
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http://dx.doi.org/10.1016/j.aquatox.2022.106205DOI Listing
July 2022

Fabrication of cellulose derivative coated spherical covalent organic frameworks as chiral stationary phases for high-performance liquid chromatographic enantioseparation.

J Chromatogr A 2022 Jul 19;1675:463155. Epub 2022 May 19.

School of Chemistry, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, South China Normal University, Guangzhou 510006, PR China; SCNU Qingyuan Institute of Science and Technology Innovation Co., Ltd, Qingyuan 511517, PR China. Electronic address:

Porous spherical silica-based chiral stationary phases (CSPs) have been commercially used in the field of chiral separation, however, the scope of their application is, to some extent, limited by the instability of silica towards mobile phase containing strong base or acid. As such, developing new matrix-based CSPs is one of the effective strategies to overcome this bottleneck in studies of chiral separation materials. In this work, we have demonstrated that stable spherical covalent organic frameworks (SCOFs) can be utilized as matrixes for the fabrication of new CSPs for the first time. Specifically, a porous imine-linked SCOF with good crystallinity, large surface area, and high chemical stability is synthesized at room temperature. Then, cellulose-tris (3,5-dimethylphenylcarbamate) (CDMPC), a typical cellulose derivative, is selected as a potential chiral selector and coated onto the robust SCOFs, giving rise to the fabrication of new [email protected] CSPs. The as-synthesized stable SCOF-based CSPs are exploited for high-performance liquid chromatographic (HPLC) enantioseparation, showing high resolution abilities for the separation of racemic compounds such as metalaxyl, 1-(1-naphthalenyl)ethanol, epoxiconazol, trans-stilbene oxide, and so on. Moreover, the prepared SCOF-based CSPs exhibit more superior acid and base stability than those of the silica-based CSPs. Our work not only uncovers the great potential of SCOFs as matrixes for constructing novel CSPs, but also expands the application of COFs in the field of enantiomeric separation under harsh base and acid conditions.
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http://dx.doi.org/10.1016/j.chroma.2022.463155DOI Listing
July 2022

Further comments on the tubarial glands.

Radiother Oncol 2022 Jul 11;172:50-53. Epub 2022 May 11.

Department of Oral & Maxillofacial Surgery, Peking University School and Hospital of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, China. Electronic address:

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http://dx.doi.org/10.1016/j.radonc.2022.05.010DOI Listing
July 2022

Facile and Site-Selective Synthesis of an Amine-Functionalized Covalent Organic Framework.

ACS Macro Lett 2021 Dec 24;10(12):1590-1596. Epub 2021 Nov 24.

School of Chemistry, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, South China Normal University, Guangzhou 510006, People's Republic of China.

Amine-functionalized covalent organic frameworks (COFs) hold great potential in diversified applications. However, the synthesis is dominated by postsynthetic modification, while the de novo synthesis allowing for direct installation of amine groups remains a formidable challenge. Herein, we develop a site-selective synthetic strategy for the facile preparation of amine-functionalized hydrazone-linked COF for the first time. A new monomer 2-aminoterephthalohydrazide (NH-Th) bearing both amine and hydrazide functionalities is designed to react with benzene-1,3,5-tricarbaldehyde (Bta). Remarkably, the different activity of amine and hydrazide groups toward aldehyde underpin the highly site-selective synthesis of an unprecedented NH-Th-Bta COF with abundant free amine groups anchored in the well-defined pore channels. Interestingly, NH-Th-Bta COF exhibits dramatically enhanced iodine uptake capacity (3.58 g g) in comparison to that of the nonfunctionalized Th-Bta COF counterpart (0.68 g g), and many reported porous adsorbents, despite its low specific surface area. Moreover, NH-Th-Bta COF possesses exceptional cycling capability and retained high iodine uptake, even after six cycles. This work not only provides a simple and straightforward route for the de novo synthesis of amine-functionalized COFs but also uncovers the great potential of amine-functionalized COFs as adsorbents in the efficient removal of radioiodine and beyond.
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http://dx.doi.org/10.1021/acsmacrolett.1c00607DOI Listing
December 2021

Evolution of associating liver partition and portal vein ligation for staged hepatectomy from 2012 to 2021: A bibliometric analysis. Review.

Int J Surg 2022 Jul 3;103:106648. Epub 2022 May 3.

Department of Liver Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College (PUMC) Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Beijing, 100730, China. Electronic address:

Background: Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) has become increasingly popular during the past few decades, and its indications have extended from patients with normal liver to post-chemotherapy patients and even patients with cirrhosis. However, few studies have assessed the publications in relation to ALPPS.

Methods: Web of Science was searched to identify studies related to ALPPS published from 2012 to 2021. The analysis was performed using the bibliometric package (Version 3.1.0) in R software.

Results: In total, 486 publications were found. These articles were published in 159 journals and authored by 2157 researchers from 694 organizations. The most prolific journal was Annals of Surgery (24 articles and 1170 citations). The most frequently cited article was published in Annals of Surgery (average citations, 72.7; total citations, 727). China was the most productive country for ALPPS publications but had comparatively less interaction with other countries. Both thematic evolution and co-occurrence network analysis showed low numbers of topics such as failure, resection, and safety among the publications but large numbers of highly cited papers on outcomes, prediction, mechanisms, multicenter analysis, and novel procedures such as liver venous deprivation. A total of 196 studies focused the clinical application of ALPPS, and most studies were IDEAL Stages I and II. The specific mechanism of ALPPS liver regeneration remains unclear.

Conclusions: This is the first bibliometric analysis offering an overview of the development of ALPPS research publications. Our findings identified prominent studies, countries, institutions, journals, and authors to indicate the future direction of ALPPS research. The role of ALPPS in liver regeneration and the long-term results of ALPPS need further study. Future research directions include comparison of ALPPS with portal vein embolization, liver venous deprivation, and other two-stage hepatectomies as well as patients' quality of life after ALPPS.
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http://dx.doi.org/10.1016/j.ijsu.2022.106648DOI Listing
July 2022

Amorphous metal-organic frameworks obtained from a crystalline precursor for the capture of iodine with high capacities.

Chem Commun (Camb) 2022 Apr 19;58(32):5013-5016. Epub 2022 Apr 19.

School of Chemistry, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, South China Normal University, Guangzhou, 510006, China. zhengsr-scnu.edu.cn.

Two amorphous metal-organic frameworks (MOFs) were obtained from crystalline Co-MOF (SCNU-Z6) temperature-induced (-SCNU-Z6) and water-immersed (-SCNU-Z6) approaches. They exhibited high iodine uptake, with the adsorption capacities of -SCNU-Z6 and -SCNU-Z6 reaching 2.05 and 5.04 g g, respectively. This work is the first report of iodine uptake by MOFs.
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http://dx.doi.org/10.1039/d1cc07229cDOI Listing
April 2022

Interactions of diclazuril enantiomers with serum albumins: Multi-spectroscopic and molecular docking approaches.

J Mol Recognit 2022 04 30;35(4):e2948. Epub 2022 Jan 30.

School of Chemistry, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, South China Normal University, Guangzhou, China.

In this work, multi-spectroscopic and molecular docking methods have been conducted in the investigation of enantioselective interactions between diclazuril enantiomers and human/bovine serum albumins (HSA/BSA). The binding constants between serum albumins (SAs) and diclazuril enantiomers revealed that SAs exhibited stronger binding affinity for (R)-diclazuril than (S)-enantiomer. In addition, the fluorescence quenching of SAs induced by diclazuril enantiomers was ascribed to static quenching mechanism, in which hydrogen bonds and Van der Waals forces were the main interactions. According to the thermodynamic study, binding of diclazuril enantiomers and SAs was an exothermic process driven by enthalpy change. Then, circular dichroism spectroscopy of SAs with diclazuril enantiomers revealed that the SAs conformation had changed in the presence of diclazuril. Moreover, molecular docking technology was applied in exploration of interactions between SAs and diclazuril enantiomers. The docking energy between SAs and (R)-diclazuril was larger than (S)-diclazuril, which indicated that the affinity of SAs with (R)-diclazuril was stronger than (S)-enantiomer. This work may provide valuable information for explaining differences in pharmacokinetics and residue elimination of diclazuril enantiomers in living organisms.
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http://dx.doi.org/10.1002/jmr.2948DOI Listing
April 2022

Letter to the editor: The role of aquaporin 9 in modeling of ornithine transcarbamylase deficiency.

Hepatology 2022 04 12;75(4):1058-1059. Epub 2022 Jan 12.

Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

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http://dx.doi.org/10.1002/hep.32293DOI Listing
April 2022

Zinc Complexes Derived from 5-Bromo-2-(((2-isopropylamino)ethyl)imino)methyl)phenol: Microwave-Assisted Synthesis, Characterization, Crystal Structures and Antibacterial Activities.

Acta Chim Slov 2021 Dec 15;68(4):921-929. Epub 2021 Dec 15.

Qiqihar University.

Three new zinc complexes [Zn3L2(μ2-η1:η1-CH3COO)2(μ2-η2:η0-CH3COO)2] (1), [ZnCl2(HL)] (2) and [ZnBr2(HL)] (3), where L = 5-bromo-2-(((2-isopropylamino)ethyl)imino)methyl)phenolate, HL = 5-bromo-2-(((2-isopropylammonio)ethyl)imino)methyl)phenolate, have been synthesized under microwave irradiation. The complexes were characterized by elemental analyses, IR, UV-Vis spectra, molar conductivity, and single crystal X-ray diffraction. X-ray analysis revealed that the Zn atoms in complex 1 are in square pyramidal and octahedral coordination, and those in complexes 2 and 3 are in tetrahedral coordination. The molecules of the complexes are linked through hydrogen bonds and π···π interactions. In order to evaluate the biological activity of the complexes, in vitro antibacterial against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa was assayed.
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http://dx.doi.org/10.17344/acsi.2021.6902DOI Listing
December 2021

Comment on "Liver Venous Deprivation (LVD) or Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS)? A Retrospective Multicentric Study": How to Choose a Way to Enhance the Growth of Future Liver Remnant in the Future.

Ann Surg 2021 Nov 16. Epub 2021 Nov 16.

Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Department of Human Anatomy, Histology & Embryology, School of Basic Medical Sciences, Peking University, Beijing, China Department of Human Anatomy, Histology & Embryology, School of Basic Medical Sciences, Peking University, Beijing, China Department of Human Anatomy, Histology & Embryology, School of Basic Medical Sciences, Peking University, Beijing, China Department of Human Anatomy, Histology & Embryology, School of Basic Medical Sciences, Peking University, Beijing, China.

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http://dx.doi.org/10.1097/SLA.0000000000005298DOI Listing
November 2021

Letter to the Editor: Is Aspirin a Drug or Just a Marker for Biliary Cancer?

Hepatology 2021 11 26;74(5):2924. Epub 2021 Aug 26.

Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

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http://dx.doi.org/10.1002/hep.32052DOI Listing
November 2021

Image quality and lesion detectability in low-dose pediatric F-FDG scans using total-body PET/CT.

Eur J Nucl Med Mol Imaging 2021 10 18;48(11):3378-3385. Epub 2021 Mar 18.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, China.

Purpose: To investigate the effects of dose reduction on image quality and lesion detectability of oncological F-FDG total-body PET/CT in pediatric oncological patients and explore the minimum threshold of administered tracer activity.

Methods: A total of 33 pediatric patients (weight 8.5-58.5 kg; age 0.8-17.6 years) underwent total-body PET/CT using uEXPLORER scanner with an F-FDG administered dose of 3.7 MBq/kg and an acquisition time of 600 s were retrospectively enrolled. Low-dose images (0.12-1.85 MBq/kg) were simulated by truncating the list-mode PET data to reducing count density. Subjective image quality was rated on a 5-point scale. Semi-quantitative uptake metrics for low-dose images were assessed using region-of-interest (ROI) analysis of healthy liver and suspected lesions and were compared with full-dose images. The micro-lesion detectability was compared among the dose-dependent PET images.

Results: Our analysis shows that sufficient subjective image quality and lesion conspicuity could be maintained down to 1/30th (0.12 MBq/kg) of the administered dose of F-FDG, where good image quality scores were given to 1/2- and 1/10- dose groups. The image noise was significantly more deranged than the overall quality and lesion conspicuity in 1/30- to 1/10-dose groups (all p < 0.05). With reduced doses, quantitative analysis of ROIs showed that SUV and SD in the liver increased gradually (p < 0.05), but SUV in the lesions and lesion-to-background ratio (LBR) showed no significant deviation down to 1/30-dose. One hundred percent of the F-FDG-avid micro-lesions identified in full-dose images were localized down to 1/15-dose images, while 97% of the lesion were localized in 1/30-dose images.

Conclusion: The total-body PET/CT might significantly decrease the administered dose upon maintaining the image quality and diagnostic performance of micro-lesions in pediatric patients. Data suggests that using total-body PET/CT, optimal image quality could be achieved with an administered dose-reduction down to 1/10-dose (0.37 MBq/kg).
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http://dx.doi.org/10.1007/s00259-021-05304-4DOI Listing
October 2021

Covalent Cross-Linking of Metal-Organic Cages: Formation of an Amorphous Cationic Porous Extended Framework for the Uptake of Oxo-Anions from Water.

Chempluschem 2021 Mar 18;86(5):699. Epub 2021 Mar 18.

School of Chemistry, South China Normal University, Guangzhou, 510006, P. R. China.

Invited for this month's cover are the collaborating groups of Sheng-Run Zheng and Wei-Guang Zhang from South China Normal University, China. The cover picture shows an amorphous cationic porous metal-organic material that constructed from the covalent linking of large cationic metal-organic cage for the removal of toxic oxo-anions from water with high capacities and rapid kinetics. Read the full text of the article at 10.1002/cplu.202000570.
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http://dx.doi.org/10.1002/cplu.202100056DOI Listing
March 2021

Covalent Cross-Linking of Metal-Organic Cages: Formation of an Amorphous Cationic Porous Extended Framework for the Uptake of Oxo-Anions from Water.

Chempluschem 2020 Nov 24;86(5):709-715. Epub 2020 Nov 24.

School of Chemistry, South China Normal University, Guangzhou, 510006, P. R. China.

Cationic amorphous metal-organic cage (MOC)-based materials capable of removing anionic pollutants from water are receiving increasing attention but they are still relatively less reported. Herein, for the first time, a cationic porous MOC-based extended framework, namely, CL-aMOC-1, was constructed by covalent linking of a cationic Pd L (L=3,5-di-pyridin-4-yl-benzaldehyde) cage with a 1,4-bis(4-aminophenyl)benzene (BAPB) linker. Interestingly, the reaction could be completed within 15 min using an amorphous MOC-based solid (aMOC-1) and BAPB as reactant via a low-temperature solid-state reaction. The CL-aMOC-1 showed improved stability, lower solubility and higher oxo-anion uptake in water compared with the original aMOC-1. The adsorption capacities for CrO , Cr O and ReO on CL-aMOC-1 were 245.1, 311.5 and 452.5 mg/g, respectively, in which the uptake of Cr(VI)-containing oxo-anions was among the highest compared with those of other metal-organic materials. The CL-aMOC-1 can selectively capture oxo-anions in the presence of competitive anions. It exhibits good reusability as over 85 % of the uptake capacity is retained after 5 cycles. Finally, it shows the ability to remove Cr(VI) ions from electroplating wastewater.
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http://dx.doi.org/10.1002/cplu.202000570DOI Listing
November 2020

Dihydromyricetin ameliorates chronic liver injury by reducing pyroptosis.

World J Gastroenterol 2020 Nov;26(41):6346-6360

Department of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China.

Background: Chronic liver injury (CLI) is now a worldwide disease. However, there is no effective treatment. Pyroptosis plays an essential role in CLI. Dihydromyricetin (DHM) resists oxidation and protects the liver. We hypothesize that the beneficial effect of DHM on CLI is related to its effect on the expression of pyroptosis-related molecules. Therefore, we studied the influence of DHM on CLI and pyroptosis.

Aim: To study the role of pyroptosis in the pathogenesis of CLI and the therapeutic mechanism of DHM.

Methods: Thirty-two mice were randomly divided into four groups: The control group was injected with olive oil, the carbon tetrachloride (CCl) group was injected with CCl, the vehicle group was injected with hydroxypropyl-β-cyclodextrin while injecting CCl and the DHM group was injected with DHM while injecting CCl. After four weeks of treatment, liver tissues from the mice were stained with hematoxylin and eosin, and oil red O. Blood was collected from the angular vein for serological analysis. The severity of CLI was estimated. Some liver tissue was sampled for immunohistochemistry, Western blotting and quantitative reverse transcription PCR to observe the changes in pyroptosis-related molecules.

Results: Serum total cholesterol, low density lipoprotein, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in the CCl group were higher than those in the control group, and serum total cholesterol, low density lipoprotein, AST and ALT in the DHM group were lower than those in the vehicle group. Hematoxylin and eosin and oil red O staining showed that there were more lipid droplets in the CCl group than in the control group, and there were fewer lipid droplets in the DHM group than in the vehicle group. Western blotting showed that the expression of the pyroptosis-related molecules caspase-1, NOD-, LRR- and pyrin domain-containing 3 (NLRP3) and gasdermin D (GSDMD)-N in the CCl group was higher than that in the control group, while expression of these proteins in the DHM group was lower than that in the vehicle group. Quantitative reverse transcription PCR results showed that the expression of the pyroptosis-related genes caspase-1, NLRP3, GSDMD and interleukin-1β (IL-1β) in the CCl group was higher than that in the control group, while there was no significant change in NLRP3 and caspase-1 expression in the DHM group compared with that in the vehicle group, and the expression of GSDMD and IL-1β was decreased.

Conclusion: DHM improves CCl-induced CLI and regulates the pyroptosis pathway in hepatocytes. DHM may be a potential therapeutic agent for CLI.
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http://dx.doi.org/10.3748/wjg.v26.i41.6346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7656208PMC
November 2020

[Clinical anatomical study on the treatment of carpal tunnel syndrome with classic Acupotomy].

Zhongguo Gu Shang 2020 Aug;33(8):745-9

Department of Acupuncture and Moxibustion, China-Japan Friendship Hospital, Beijing 100029, China.

Objective: To explore the safety of classic Acupotomy in the treatment of carpal tunnel syndrome.

Methods: Twenty six adult specimens (15 males and 11 females), aged 60 to 95(82.54±6.94) years old, were selected from 10% formalin antiseptic fixation. There were 52 sides(two of them could not be tested). The study period was from November 2017 to May 2018. The specimens were collected from the body donation center of the school of basic medicine, Peking University. The operation of releasing the transverse carpal ligament on the human body specimen was simulated by the classic acupotomy, and the distance from the four points to the surrounding anatomical structure was measured to calculate the direct injury rate to the nerve and blood vessels, and the shortest distance between the acupotomy and the nerve and blood vessels was defined as ≥2 mm as safety.

Results: In the experimental operation, the direct injury rate of nerve and blood vessel was 14% and 12% respectively. There was significant difference in the rate of direct nerve injury between the four injection points (<0.05). There was no significant difference in the rate of direct vascular injury between the four injection points (>0.05). Among the four points, there was a statistically significant difference in the safety of nerves(<0.05), and the safety of point 1 and point 3 of radial injection was higher than that of point 2 and point 4 of ulnar injection(<0.05). There was significant difference in the safety of blood vessels between the four points(<0.05), and the safety of radial point 1 was higher than that of ulnar point 2 and point 4 (<0.05).

Conclusion: The safety of the classic Acupotomy for carpal tunnel syndrome is related to the location of the needle entry point, and the safety of theradial proximal end of the needle is the highest.
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http://dx.doi.org/10.12200/j.issn.1003-0034.2020.08.012DOI Listing
August 2020

A Mn(II)-MOF with inherent missing metal-ion defects based on an imidazole-tetrazole tripodal ligand and its application in supercapacitors.

Dalton Trans 2020 Sep;49(35):12150-12155

School of Chemistry, South China Normal University, Guangzhou, 510006, China. zhengsr-scnu.edu.cn wgzhang-scnu.edu.cn.

A metal-organic framework (MOF), namely SCNU-Z3, based on an imidazole-tetrazole tripodal ligand and Mn(ii), has been constructed. It exhibits a porous 3D framework composed of truncated octahedron cage subunits. Unexpected ligand-induced missing metal-ion defects were observed in the framework. In addition, the application of SCNU-Z3 in a supercapacitor was performed.
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http://dx.doi.org/10.1039/d0dt01666gDOI Listing
September 2020

N-methoxy-β-carboline alkaloids with inhibitory activities against Aβ aggregation and acetylcholinesterase from the stems of Picrasma quassioides.

Bioorg Chem 2020 08 25;101:104043. Epub 2020 Jun 25.

Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, People's Republic of China; College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China. Electronic address:

Nine new N-methoxy-β-carboline alkaloids (NMCAs) (1a/1b-3a/3b and 4-6) and two known NMCAs (7 and 8) were isolated from the stems of Picrasma quassioides. Their structures were elucidated by spectroscopic data analyses, quantum chemical calculations, and single-crystal X-ray crystallographic data. An analysis of the C NMR chemical shifts of the N-methoxy groups in these NMCAs and 41 gathered known compounds reveals the phenomenon that the chemical shifts of all these N-methoxy groups are greater than δ 62, which can be used to recognize the N-methoxy group rapidly. In addition, the acetylcholinesterase (AChE) and Aβ aggregation inhibitory activities of 1-8 were evaluated. Compounds 1, 2, 7, and 8 displayed AChE inhibitory activity with IC values of 14.9, 13.2, 17.6, and 43.9 μM, respectively. Compound 2 showed inhibition activity against Aβ aggregation with an IC value of 10.1 μM.
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http://dx.doi.org/10.1016/j.bioorg.2020.104043DOI Listing
August 2020

Sporormielones A-E, bioactive novel C-C coupled orsellinic acid derivative dimers, and their biosynthetic origin.

Chem Commun (Camb) 2020 Apr 25;56(33):4607-4610. Epub 2020 Mar 25.

Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China.

Sporormielones A-E (1-5), novel C-C coupled orsellinic acid derivative dimers containing tricyclic cores with a dimethylcyclopentenone unit, were obtained, of which 1-3 and 5 showed obvious short-term memory improvement activity in AD flies. Based on transcriptome analysis, C labelling, and gene deletion, their plausible biosynthetic mechanism was proposed.
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http://dx.doi.org/10.1039/d0cc00855aDOI Listing
April 2020

Anatomical and clinical study of a new mallet fracture classification method.

Chin Med J (Engl) 2020 Mar(6):657-663

Department of Hand Surgery, Beijing Jishuitan Hospital, Beijing 100035, China.

Background: Mallet fracture is avulsion of the terminal extensor tendon from the base of the distal phalangeal bone with a bony fragment. This study was performed to evaluate the anatomical characteristics of mallet fractures, investigate a new mallet fracture classification system using anatomical and imaging methods, and discuss the treatment schemes for different types of mallet fracture.

Methods: Sixty-four fresh cadaveric fingers were divided into four groups, and models of different types of mallet fracture with distal interphalangeal joint instability were established by dissecting 25%, 50%, 75%, and 100% of the bilateral collateral ligaments. The effect of mallet fractures on the stability of the distal interphalangeal joint was then observed. The lateral radiographs of mallet fractures in 168 patients were analyzed and classified according to the involvement of the joint surface in the fracture, the thickness of fracture, the untreated time after injury, and the complication of distal interphalangeal joint palmar subluxation. Forty-seven patients were surgically treated by reconstruction of extensor tendon insertion, the Ishiguro method, or single Kirschner wire fixation.

Results: The established mallet fracture model showed that the distal interphalangeal joint was stable when the bilateral collateral ligaments were cut off by 25% (t = -0.415, P = 0.684) and significantly unstable when this range was ≥50% (50% transection: t = -6.363, P < 0.001; 75% transection: t = -17.036, P < 0.001; 100% transection: t = -30.977, P < 0.001, respectively). The mallet fractures were divided into Types I, II, and III (fracture involving <20%, 20%-50%, and >50% of the joint surface, respectively). Type II was further divided into Types IIa and IIb according to whether the course of injury was < or ≥2 weeks, respectively. The mean post-operative flexion of the distal interphalangeal joint was 63.4° ± 7.9°, and the mean extension lag was 6.7° ± 4.6°.

Conclusions: The lateral collateral ligament is the main factor that maintains the stability of the distal interphalangeal joint. Classification that combines the involvement of the joint surface in the fracture, the thickness of the fracture, and the untreated time after injury is reasonable and will help to choose an appropriate operational method.
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http://dx.doi.org/10.1097/CM9.0000000000000676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190220PMC
March 2020

Rational design of ultra-small photoluminescent copper nano-dots loaded PLGA micro-vessels for targeted co-delivery of natural piperine molecules for the treatment for epilepsy.

J Photochem Photobiol B 2020 Apr 23;205:111805. Epub 2020 Jan 23.

Department of neurology, Mudanjiang Second Hospital, China.

In recent days, reported researches demonstrated that encapsulation of natural hydrophobic drug molecules (Piperine) into the biodegradable polymer system with nanoformulations opens a novel prospect in bio-nanomedicine field. Generally, the nanostructured materials embedded with the drug molecules could render enhanced efficiency in therapies. Piperine is a chief alkaloid compound of natural black pepper exhibits excellent anti-convulsant efficiency in the anti-epileptic treatment. Nonetheless, the poor water solubility of the piperine molecules has some difficulties in drug delivery and clinical applications. Herein we report the synthesis of Copper oxide quantum dots coated Hyaluronic acid (HA)/ Poly(lactic-co-glycolic acid) (PLGA) with for the effective delivery of piperine in the targeted drug delivery for epilepsy treatment. The physicochemical characterization was performed using the as prepared material. The crystal structure, surface morphology and the elemental composition were investigated from XRD, SEM, TEM and EDX analyses respectively. The surface morphology clearly stated the loading of CuO QDs loaded HA/PLGA microspheres. The capping of the polymer matrix was also studied using FTIR analysis. A Photoluminescence spectrum is also recorded. This study was illustrating that Piperine loaded [email protected]/PLGA nanostructures exhibit improved neuroprotection and encourage the activation of astrocytes in chemical kindling model of epilepsy. This proposed material could be a novel and effective therapeutic platform for the targeted drug delivery systems.
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http://dx.doi.org/10.1016/j.jphotobiol.2020.111805DOI Listing
April 2020

Cu-MOF derived Cu-C nanocomposites towards high performance electrochemical supercapacitors.

RSC Adv 2020 Jan 28;10(8):4621-4629. Epub 2020 Jan 28.

School of Chemistry, South China Normal University Guangzhou 510006 China

For the development of asymmetric supercapacitors with higher energy density, the study of new electrode materials with high capacitance is a priority. Herein, the electrochemical behavior of nano copper in alkaline electrolyte is first discovered. It is found that there are two obvious reversible redox symmetric peaks in the range of -0.8-0.2 V in the alkaline electrolyte, corresponding to the conversion of copper into cuprous ions, and then converting cuprous ions into copper ions, indicating that the nanocomposite electrode has the characteristics of a pseudocapacitive reaction. It has a specific capacitance of up to 318 F g at a current density of 1 A g, which remains at nearly 100% after 10 000 cycles at the same current density. When assembled with a Ni(OH)-based electrode into an asymmetric supercapacitor, the device shows excellent capacitive behavior and good reaction reversibility. At 0.4 A g, the supercapacitor delivers a reversible capacity of 8.33 F g with an energy density of 13.5 mW h g. This study first discovers the electrochemical behavior of nano copper, which can provide a new research idea for further expanding the negative electrodes of supercapacitors with higher energy density.
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http://dx.doi.org/10.1039/c9ra09738dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9049291PMC
January 2020

A new QCM signal enhancement strategy based on [email protected] framework complex for miRNA detection.

Anal Chim Acta 2020 Jan 19;1095:212-218. Epub 2019 Oct 19.

School of Chemistry, South China Normal University, Guangzhou, 510006, China. Electronic address:

Sensitive and selective detection of miRNA is of great significance for the early diagnosis of human diseases, especially for cancers. Quartz crystal microbalance (QCM) is an effective tool for detecting biological molecules; however, the application of QCM for miRNA detection is still very limited. One of the great needs for QCM detection is to further improve the QCM signal. Herein, for the first time, we promote a new signal enhancement strategy for the detection of miRNA by QCM. First, a hairpin biotin-modified DNA was used as a probe DNA, which exposes the biotin site when interacting with target miRNA. Then, a [email protected] framework ([email protected]) complex formed by electrostatic attractions between SA and a MOF was introduced into the QCM detection system. The [email protected] complexes serve as both a signal amplifier and a specific recognition element via specific biotin-SA interactions. The strategy was applied to the detection of a colorectal cancer marker, miR-221, by using a stable Zr(IV)-MOF, UiO-66-NH. The detection linear range was 10 fM-1 nM, the detection limit was 6.9 fM, and the relative standard deviation (RSD) (n = 5) was lower than 10% in both simulated conditions and the real serum environment. Furthermore, the detection limit reached 0.79 aM when coupled with the isothermal exponential amplification reaction (EXPAR).
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http://dx.doi.org/10.1016/j.aca.2019.10.034DOI Listing
January 2020

The interaction of an amorphous metal-organic cage-based solid (aMOC) with miRNA/DNA and its application on a quartz crystal microbalance (QCM) sensor.

Chem Commun (Camb) 2020 Jan 12;56(4):591-594. Epub 2019 Dec 12.

School of Chemistry, South China Normal University, Guangzhou, 510006, China. zhengsr-scnu.edu.cn wgzhang-scnu.edu.cn.

The interaction between an aMOC and miRNA/DNA is studied and the use of a signal probe DNA (spDNA)@aMOC complex as an effective amplifier in a QCM sensor to detect miRNA is developed. The signal can be significantly enhanced, which leads to improved performance when detecting and distinguishing miRNAs.
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http://dx.doi.org/10.1039/c9cc08014gDOI Listing
January 2020

Diagnostic efficacy of serum anti-phospholipase A2 receptor antibodies for idiopathic membranous nephropathy in patients with diabetic kidney disease.

Clin Chim Acta 2020 Mar 13;502:222-226. Epub 2019 Nov 13.

Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Diseases, Beijing, China. Electronic address:

Aim: Serum anti-phospholipase A2 receptor (anti-PLA2R) antibodies are highly accurate in diagnosing idiopathic membranous nephropathy (IMN) in populations with kidney disease. However, the diagnostic value of anti-PLA2R antibodies for IMN in diabetic kidney disease (DKD) is unclear. The objective of this study is to determine the diagnostic efficacy and the optimal cut-off value of this marker in populations with DKD.

Methods: This study included 227 patients with type 2 diabetes who were admitted to the Department of Nephrology of the Chinese People's Liberation Army General Hospital from May 2016 to January 2018 and underwent pathological diagnosis by renal biopsy. Anti-PLA2R antibodies were detected by enzyme-linked immunosorbent assay in this population. According to the pathological results, the participants were divided into an IMN group and non-membranous nephropathy (non-MN) group. The clinical characteristics were analyzed, the diagnostic ability of anti-PLA2R antibodies was evaluated, and the receiver operating characteristic (ROC) curve was constructed to obtain the optimal cut-off value.

Results: There were 45 patients in the IMN group, accounting for 19.8% of the study sample. The patients in this group were older at the time of renal biopsy than the non-MN group and presented a shorter duration of diabetes, better glycemic control, lower blood pressure and uric acid, and better renal function; in addition, their clinical symptoms indicated nephrotic syndrome. The optimal cut-off value for anti-PLA2R antibodies for the diagnosis of IMN in DKD was 2.71 Ru/ml, sensitivity was 0.800, specificity was 0.951, positive predictive value was 0.800, negative predictive value was 0.951, accuracy was 0.921, and the Yoden index was 0.750. The area under the ROC curve was 0.87 (95% CI, 0.788-0.952) (p < 0.001).

Conclusions: Patients in the IMN group were older, had better renal function and general condition, and the clinical symptoms indicated nephrotic syndrome. Anti-PLA2R antibodies had a good diagnostic performance for IMN in the population with DKD, and the optimal cut-off value was 2.71.
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http://dx.doi.org/10.1016/j.cca.2019.11.004DOI Listing
March 2020

Features of intra-hamate vascularity and its possible relationship with avascular risk of hamate fracture.

Chin Med J (Engl) 2019 Nov;132(21):2572-2580

Department of Hand Surgery, Beijing Jishuitan Hospital, Beijing 100035, China.

Background: The angiography with micro-computed tomography (micro-CT) has been proved its great advantages on investigating the intra-osseous vascularity of carpal bones. But few researches have focused on the intra-hamate vascularity. This study aimed to illustrate the intra-osseous arteries of the hamate and the relationship between the intra-hamate vascularity and the avascular risk of different types of hamate fractures.

Methods: Six normal cadaveric hamates were investigated with red lead (Pb3O4) micro-CT angiography. The intra-osseous arteries of specimens were clearly enhanced and the three-dimensional model was reconstructed. In order to study the features of the arterial entrances and intra-hamate vascularity, the diameters, quantities, locations of enhanced arteries, and the locations of transversal/proximal pole fracture lines on the body of the hamate were statistically compared. Besides, in order to analyze the relationship between intra-hamate vascularities and different hamate fractures, 127 cases of hamate fractures who presented in our hospital from March 2003 to June 2017 were retrospectively studied.

Results: A total of 94 cases were followed up (range: 4-37 months; mean: 12.4 months) effectively. The overall union rate of hamate fractures was as high as 92.6% (87 of 94 cases), while non-union of fracture on hamate hook was more common (P = 0.031). The arterial entrances were located around the dorsal, volar, radial, ulnar non-articular surfaces of the hamate body and the hook of the hamate. Generally, there were one to two trunk arteries on the volar non-articular surface and one to three trunk arteries on the dorsal non-articular surface. They formed one or two arterial arches, from which some branches were emitted and supplied the proximal parts. The intra-osseous vascularities of the hamate body were generally located in the radial part. The blood supply of the hook was mainly from the volar non-articular surface in most specimens. Hamate fractures could be classified into four types: fractures of the transversal/proximal pole, medial tuberosity, dorsal coronal of the hamate body, and fractures of the hamate hook.

Conclusions: This study showed new features of intra-hamate vascularity and the results will guide surgeons to reduce the vascular damage during the hamate fracture operations. The fracture lines of different types of hamate fractures may disrupt the intra-hamate arteries. The intra-hamate vascularities will have different influences on the avascular risks of different hamate fractures.
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http://dx.doi.org/10.1097/CM9.0000000000000417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6846259PMC
November 2019

An unprecedented 2D covalent organic framework with an htb net topology.

Chem Commun (Camb) 2019 Nov 24;55(89):13454-13457. Epub 2019 Oct 24.

School of Chemistry, South China Normal University, Guangzhou 510006, P. R. China.

A 2D imine-linked COF with a hitherto unreported htb type topology was synthesized from a linear diamine linker and a judiciously designed tetra-aldehyde building block. This work opens the door to the development of COFs with unprecedented topologies and may broaden the scope of COF functional materials by pore size and pore surface engineering.
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http://dx.doi.org/10.1039/c9cc06780aDOI Listing
November 2019
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