Wei-Chiang Shen

Wei-Chiang Shen

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Wei-Chiang Shen

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The Blue-Light Photoreceptor Gene Regulates the Phototropic Response and Fruiting-Body Development in the Homothallic Ascomycete .

Authors:
Kulsumpun Krobanan Syun-Wun Liang Ho-Chen Chiu Wei-Chiang Shen

Appl Environ Microbiol 2019 Jun 30;85(12). Epub 2019 May 30.

Department of Plant Pathology and Microbiology, National Taiwan University, Taipei, Taiwan

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http://dx.doi.org/10.1128/AEM.02206-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544823PMC
June 2019

Dynamic Insertion of Pot3 in Prevailing in a Field Rice Blast Population in the Philippines Led to the High Virulence Frequency Against the Resistance Gene in Rice.

Authors:
Toluwase Olukayode Berlaine Quime Yin-Chi Shen Mary Jeannie Yanoria Suobing Zhang Jianyuan Yang Xiaoyuan Zhu Wei-Chiang Shen Andreas von Tiedemann Bo Zhou

Phytopathology 2019 May 16;109(5):870-877. Epub 2019 Mar 16.

2 International Rice Research Institute, DAPO Box 7777, Metro Manila, Philippines.

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http://dx.doi.org/10.1094/PHYTO-06-18-0198-RDOI Listing
May 2019

The smut fungus Ustilago esculenta has a bipolar mating system with three idiomorphs larger than 500 kb.

Authors:
Syun-Wun Liang Yen-Hua Huang Jian-Ying Chiu Hsin-Wan Tseng Jin-Hsing Huang Wei-Chiang Shen

Fungal Genet Biol 2019 05 19;126:61-74. Epub 2019 Feb 19.

Department of Plant Pathology and Microbiology, National Taiwan University, Taipei 10617, Taiwan, ROC. Electronic address:

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http://dx.doi.org/10.1016/j.fgb.2019.02.007DOI Listing
May 2019

Genome-wide association study of rice genes and loci conferring resistance to Magnaporthe oryzae isolates from Taiwan.

Authors:
Heng-An Lin Szu-Yu Chen Fang-Yu Chang Chih-Wei Tung Yi-Chia Chen Wei-Chiang Shen Ruey-Shyang Chen Chih-Wen Wu Chia-Lin Chung

Bot Stud 2018 Dec 21;59(1):32. Epub 2018 Dec 21.

Department of Plant Pathology and Microbiology, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei, 10617, Taiwan.

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http://dx.doi.org/10.1186/s40529-018-0248-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303224PMC
December 2018

Population genomic analysis of the rice blast fungus reveals specific events associated with expansion of three main clades.

Authors:
Zhenhui Zhong Meilian Chen Lianyu Lin Yijuan Han Jiandong Bao Wei Tang Lili Lin Yahong Lin Rewish Somai Lin Lu Wenjing Zhang Jian Chen Yonghe Hong Xiaofeng Chen Baohua Wang Wei-Chiang Shen Guodong Lu Justice Norvienyeku Daniel J Ebbole Zonghua Wang

ISME J 2018 08 22;12(8):1867-1878. Epub 2018 Mar 22.

State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou, 350002, China.

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http://www.nature.com/articles/s41396-018-0100-6
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http://dx.doi.org/10.1038/s41396-018-0100-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051997PMC
August 2018

Nuclear dynamics in the homothallic ascomycete Sordaria fimicola.

Authors:
Kulsumpun Krobanan Wei-Chiang Shen

Bot Stud 2018 Jul 3;59(1):17. Epub 2018 Jul 3.

Department of Plant Pathology and Microbiology, National Taiwan University, No. 1 Roosevelt Road, Sec. 4, Taipei, 10617, Taiwan.

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http://dx.doi.org/10.1186/s40529-018-0233-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029984PMC
July 2018

Acid-sensitive hybrid polymeric micelles containing a reversibly activatable cell-penetrating peptide for tumor-specific cytoplasm targeting.

Authors:
Baoqiang Tang Jennica L Zaro Yan Shen Qian Chen Yinglan Yu Pingping Sun Yanqi Wang Wei-Chiang Shen Jiasheng Tu Chunmeng Sun

J Control Release 2018 06 10;279:147-156. Epub 2018 Apr 10.

Center for Research Development, Evaluation of Pharmaceutical Excipients and Generic Drugs, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, China; State Key Laboratory of Nature Medicines, Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01683659183019
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http://dx.doi.org/10.1016/j.jconrel.2018.04.016DOI Listing
June 2018

Biodistribution, activation, and retention of proinsulin-transferrin fusion protein in the liver: Mechanism of liver-targeting as an insulin prodrug.

Authors:
Yuqian Liu Hsuan-Yao Wang Li Zhou Yang Su Wei-Chiang Shen

J Control Release 2018 04 20;275:186-191. Epub 2018 Feb 20.

Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, 1985 Zonal Ave, Los Angeles, CA90089, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2018.02.030DOI Listing
April 2018

Tissue barriers and novel approaches to achieve hepatoselectivity of subcutaneously-injected insulin therapeutics.

Authors:
Juntang Shao Jennica L Zaro Wei-Chiang Shen

Tissue Barriers 2016 Apr-Jun;4(2):e1156804. Epub 2016 Mar 4.

Department of Pharmacology and Pharmaceutical Sciences, University of Southern California , Los Angeles, CA, USA.

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http://dx.doi.org/10.1080/21688370.2016.1156804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910833PMC
February 2018

Characterization and Oral Delivery of Proinsulin-Transferrin Fusion Protein Expressed Using ExpressTec.

Authors:
Yu-Sheng Chen Jennica L Zaro Deshui Zhang Ning Huang Andrew Simon Wei-Chiang Shen

Int J Mol Sci 2018 Jan 26;19(2). Epub 2018 Jan 26.

Department of Pharmacology and Pharmaceutical Sciences, University of Southern California School of Pharmacy, Los Angeles, CA 90089, USA.

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http://dx.doi.org/10.3390/ijms19020378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855600PMC
January 2018

Characterization of Polyelectrolyte Complex Formation Between Anionic and Cationic Poly(amino acids) and Their Potential Applications in pH-Dependent Drug Delivery.

Authors:
Zoë Folchman-Wagner Jennica Zaro Wei-Chiang Shen

Molecules 2017 Jun 30;22(7). Epub 2017 Jun 30.

Department of Pharmaceutical Sciences, University of Southern California School of Pharmacy, 1985 Zonal Avenue, Los Angeles, CA 90089, USA.

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http://dx.doi.org/10.3390/molecules22071089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152117PMC
June 2017

Single chain Fc-dimer-human growth hormone fusion protein for improved drug delivery.

Authors:
Li Zhou Hsuan-Yao Wang Shanshan Tong Curtis T Okamoto Wei-Chiang Shen Jennica L Zaro

Biomaterials 2017 02 27;117:24-31. Epub 2016 Nov 27.

Department of Pharmacology and Pharmaceutical Sciences, University of Southern California School of Pharmacy, 1985 Zonal Ave, Los Angeles, CA 90089-9121, United States; Department of Pharmaceutical Sciences, West Coast University School of Pharmacy, 590 N. Vermont Ave, Los Angeles, CA 90004, United States. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2016.11.051DOI Listing
February 2017

Proinsulin-Transferrin Fusion Protein Exhibits a Prolonged and Selective Effect on the Control of Hepatic Glucose Production in an Experimental Model of Type 1 Diabetes.

Authors:
Juntang Shao Jennica L Zaro Wei-Chiang Shen

Mol Pharm 2016 08 11;13(8):2641-6. Epub 2016 Jul 11.

Department of Pharmacology and Pharmaceutical Sciences, University of Southern California , 1985 Zonal Avenue, Los Angeles, California 90033, United States.

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http://dx.doi.org/10.1021/acs.molpharmaceut.6b00168DOI Listing
August 2016

Selective Intracellular Delivery of Recombinant Arginine Deiminase (ADI) Using pH-Sensitive Cell Penetrating Peptides To Overcome ADI Resistance in Hypoxic Breast Cancer Cells.

Authors:
Tzyy-Harn Yeh Yun-Ru Chen Szu-Ying Chen Wei-Chiang Shen David K Ann Jennica L Zaro Li-Jiuan Shen

Mol Pharm 2016 Jan 17;13(1):262-71. Epub 2015 Dec 17.

School of Pharmacy, College of Medicine, National Taiwan University , Taipei, Taiwan.

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http://dx.doi.org/10.1021/acs.molpharmaceut.5b00706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544535PMC
January 2016

Proinsulin-transferrin fusion protein as a novel long-acting insulin analog for the inhibition of hepatic glucose production.

Authors:
Yan Wang Juntang Shao Jennica L Zaro Wei-Chiang Shen

Diabetes 2014 May 18;63(5):1779-88. Epub 2013 Dec 18.

Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA.

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http://dx.doi.org/10.2337/db13-0973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994961PMC
May 2014

Interaction between cell-penetrating peptides and acid-sensitive anionic oligopeptides as a model for the design of targeted drug carriers.

Authors:
Chunmeng Sun Wei-Chiang Shen Jiasheng Tu Jennica L Zaro

Mol Pharm 2014 May 15;11(5):1583-90. Epub 2014 Apr 15.

State Key Laboratory of Natural Medicines, Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University , 24 Tong Jia Xiang, Nanjing 210009, China.

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http://dx.doi.org/10.1021/mp400747kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012841PMC
May 2014

Tumor targeting of a cell penetrating peptide by fusing with a pH-sensitive histidine-glutamate co-oligopeptide.

Authors:
Likun Fei Li-Peng Yap Peter S Conti Wei-Chiang Shen Jennica L Zaro

Biomaterials 2014 Apr 6;35(13):4082-7. Epub 2014 Feb 6.

Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 1985 Zonal Ave, Los Angeles, CA 90033, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2014.01.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954778PMC
April 2014

Fatty acids as therapeutic auxiliaries for oral and parenteral formulations.

Authors:
Michael J Hackett Jennica L Zaro Wei-Chiang Shen Patrick C Guley Moo J Cho

Adv Drug Deliv Rev 2013 Oct 17;65(10):1331-9. Epub 2012 Aug 17.

University of North Carolina, Chapel Hill, School of Pharmacy, Division of Molecular Pharmaceutics, USA.

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http://dx.doi.org/10.1016/j.addr.2012.07.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537895PMC
October 2013

Fusion protein linkers: property, design and functionality.

Authors:
Xiaoying Chen Jennica L Zaro Wei-Chiang Shen

Adv Drug Deliv Rev 2013 Oct 29;65(10):1357-69. Epub 2012 Sep 29.

Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA.

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http://dx.doi.org/10.1016/j.addr.2012.09.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726540PMC
October 2013

Vesicle-to-cytosol transport of disulfide-linked cargo mediated by an amphipathic cell-penetrating peptide.

Authors:
Randall Kenien Wei-Chiang Shen Jennica L Zaro

J Drug Target 2012 Nov 20;20(9):793-800. Epub 2012 Sep 20.

Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA.

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http://dx.doi.org/10.3109/1061186X.2012.719899DOI Listing
November 2012

Characterization of transferrin receptor-mediated endocytosis and cellular iron delivery of recombinant human serum transferrin from rice (Oryza sativa L.).

Authors:
Deshui Zhang Hsin-Fang Lee Steven C Pettit Jennica L Zaro Ning Huang Wei-Chiang Shen

BMC Biotechnol 2012 Nov 30;12:92. Epub 2012 Nov 30.

Ventria Bioscience, Fort Collins, CO 80524, USA.

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http://dx.doi.org/10.1186/1472-6750-12-92DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521190PMC
November 2012

Mass spectrometry study of a transferrin-based protein drug reveals the key role of protein aggregation for successful oral delivery.

Authors:
Cedric E Bobst Shunhai Wang Wei-Chiang Shen Igor A Kaltashov

Proc Natl Acad Sci U S A 2012 Aug 6;109(34):13544-8. Epub 2012 Aug 6.

Department of Chemistry, University of Massachusetts, Amherst, MA 01003, USA.

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http://dx.doi.org/10.1073/pnas.1206924109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427120PMC
August 2012

Effects of Lipofectamine 2000/siRNA complexes on autophagy in hepatoma cells.

Authors:
Robert H Mo Jennica L Zaro Jing-Hsiung James Ou Wei-Chiang Shen

Mol Biotechnol 2012 May;51(1):1-8

Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA.

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http://dx.doi.org/10.1007/s12033-011-9422-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469361PMC
May 2012

MAP-mediated nuclear delivery of a cargo protein.

Authors:
Randall Kenien Jennica L Zaro Wei-Chiang Shen

J Drug Target 2012 May 9;20(4):329-37. Epub 2012 Jan 9.

Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA.

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http://dx.doi.org/10.3109/1061186X.2011.649481DOI Listing
May 2012

Pharmacokinetics of recombinant bifunctional fusion proteins.

Authors:
Xiaoying Chen Jennica L Zaro Wei-Chiang Shen

Expert Opin Drug Metab Toxicol 2012 May 20;8(5):581-95. Epub 2012 Mar 20.

University of Southern California School of Pharmacy, Department of Pharmacology and Pharmaceutical Sciences, CA 90089-9121, USA.

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http://dx.doi.org/10.1517/17425255.2012.673585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718553PMC
May 2012

Guidelines for the use and interpretation of assays for monitoring autophagy.

Authors:
Daniel J Klionsky Fabio C Abdalla Hagai Abeliovich Robert T Abraham Abraham Acevedo-Arozena Khosrow Adeli Lotta Agholme Maria Agnello Patrizia Agostinis Julio A Aguirre-Ghiso Hyung Jun Ahn Ouardia Ait-Mohamed Slimane Ait-Si-Ali Takahiko Akematsu Shizuo Akira Hesham M Al-Younes Munir A Al-Zeer Matthew L Albert Roger L Albin Javier Alegre-Abarrategui Maria Francesca Aleo Mehrdad Alirezaei Alexandru Almasan Maylin Almonte-Becerril Atsuo Amano Ravi Amaravadi Shoba Amarnath Amal O Amer Nathalie Andrieu-Abadie Vellareddy Anantharam David K Ann Shailendra Anoopkumar-Dukie Hiroshi Aoki Nadezda Apostolova Giuseppe Arancia John P Aris Katsuhiko Asanuma Nana Y O Asare Hisashi Ashida Valerie Askanas David S Askew Patrick Auberger Misuzu Baba Steven K Backues Eric H Baehrecke Ben A Bahr Xue-Yuan Bai Yannick Bailly Robert Baiocchi Giulia Baldini Walter Balduini Andrea Ballabio Bruce A Bamber Edward T W Bampton Gábor Bánhegyi Clinton R Bartholomew Diane C Bassham Robert C Bast Henri Batoko Boon-Huat Bay Isabelle Beau Daniel M Béchet Thomas J Begley Christian Behl Christian Behrends Soumeya Bekri Bryan Bellaire Linda J Bendall Luca Benetti Laura Berliocchi Henri Bernardi Francesca Bernassola Sébastien Besteiro Ingrid Bhatia-Kissova Xiaoning Bi Martine Biard-Piechaczyk Janice S Blum Lawrence H Boise Paolo Bonaldo David L Boone Beat C Bornhauser Karina R Bortoluci Ioannis Bossis Frédéric Bost Jean-Pierre Bourquin Patricia Boya Michaël Boyer-Guittaut Peter V Bozhkov Nathan R Brady Claudio Brancolini Andreas Brech Jay E Brenman Ana Brennand Emery H Bresnick Patrick Brest Dave Bridges Molly L Bristol Paul S Brookes Eric J Brown John H Brumell Nicola Brunetti-Pierri Ulf T Brunk Dennis E Bulman Scott J Bultman Geert Bultynck Lena F Burbulla Wilfried Bursch Jonathan P Butchar Wanda Buzgariu Sergio P Bydlowski Ken Cadwell Monika Cahová Dongsheng Cai Jiyang Cai Qian Cai Bruno Calabretta Javier Calvo-Garrido Nadine Camougrand Michelangelo Campanella Jenny Campos-Salinas Eleonora Candi Lizhi Cao Allan B Caplan Simon R Carding Sandra M Cardoso Jennifer S Carew Cathleen R Carlin Virginie Carmignac Leticia A M Carneiro Serena Carra Rosario A Caruso Giorgio Casari Caty Casas Roberta Castino Eduardo Cebollero Francesco Cecconi Jean Celli Hassan Chaachouay Han-Jung Chae Chee-Yin Chai David C Chan Edmond Y Chan Raymond Chuen-Chung Chang Chi-Ming Che Ching-Chow Chen Guang-Chao Chen Guo-Qiang Chen Min Chen Quan Chen Steve S-L Chen WenLi Chen Xi Chen Xiangmei Chen Xiequn Chen Ye-Guang Chen Yingyu Chen Yongqiang Chen Yu-Jen Chen Zhixiang Chen Alan Cheng Christopher H K Cheng Yan Cheng Heesun Cheong Jae-Ho Cheong Sara Cherry Russ Chess-Williams Zelda H Cheung Eric Chevet Hui-Ling Chiang Roberto Chiarelli Tomoki Chiba Lih-Shen Chin Shih-Hwa Chiou Francis V Chisari Chi Hin Cho Dong-Hyung Cho Augustine M K Choi DooSeok Choi Kyeong Sook Choi Mary E Choi Salem Chouaib Divaker Choubey Vinay Choubey Charleen T Chu Tsung-Hsien Chuang Sheau-Huei Chueh Taehoon Chun Yong-Joon Chwae Mee-Len Chye Roberto Ciarcia Maria R Ciriolo Michael J Clague Robert S B Clark Peter G H Clarke Robert Clarke Patrice Codogno Hilary A Coller María I Colombo Sergio Comincini Maria Condello Fabrizio Condorelli Mark R Cookson Graham H Coombs Isabelle Coppens Ramon Corbalan Pascale Cossart Paola Costelli Safia Costes Ana Coto-Montes Eduardo Couve Fraser P Coxon James M Cregg José L Crespo Marianne J Cronjé Ana Maria Cuervo Joseph J Cullen Mark J Czaja Marcello D'Amelio Arlette Darfeuille-Michaud Lester M Davids Faith E Davies Massimo De Felici John F de Groot Cornelis A M de Haan Luisa De Martino Angelo De Milito Vincenzo De Tata Jayanta Debnath Alexei Degterev Benjamin Dehay Lea M D Delbridge Francesca Demarchi Yi Zhen Deng Jörn Dengjel Paul Dent Donna Denton Vojo Deretic Shyamal D Desai Rodney J Devenish Mario Di Gioacchino Gilbert Di Paolo Chiara Di Pietro Guillermo Díaz-Araya Inés Díaz-Laviada Maria T Diaz-Meco Javier Diaz-Nido Ivan Dikic Savithramma P Dinesh-Kumar Wen-Xing Ding Clark W Distelhorst Abhinav Diwan Mojgan Djavaheri-Mergny Svetlana Dokudovskaya Zheng Dong Frank C Dorsey Victor Dosenko James J Dowling Stephen Doxsey Marlène Dreux Mark E Drew Qiuhong Duan Michel A Duchosal Karen Duff Isabelle Dugail Madeleine Durbeej Michael Duszenko Charles L Edelstein Aimee L Edinger Gustavo Egea Ludwig Eichinger N Tony Eissa Suhendan Ekmekcioglu Wafik S El-Deiry Zvulun Elazar Mohamed Elgendy Lisa M Ellerby Kai Er Eng Anna-Mart Engelbrecht Simone Engelender Jekaterina Erenpreisa Ricardo Escalante Audrey Esclatine Eeva-Liisa Eskelinen Lucile Espert Virginia Espina Huizhou Fan Jia Fan Qi-Wen Fan Zhen Fan Shengyun Fang Yongqi Fang Manolis Fanto Alessandro Fanzani Thomas Farkas Jean-Claude Farré Mathias Faure Marcus Fechheimer Carl G Feng Jian Feng Qili Feng Youji Feng László Fésüs Ralph Feuer Maria E Figueiredo-Pereira Gian Maria Fimia Diane C Fingar Steven Finkbeiner Toren Finkel Kim D Finley Filomena Fiorito Edward A Fisher Paul B Fisher Marc Flajolet Maria L Florez-McClure Salvatore Florio Edward A Fon Francesco Fornai Franco Fortunato Rati Fotedar Daniel H Fowler Howard S Fox Rodrigo Franco Lisa B Frankel Marc Fransen José M Fuentes Juan Fueyo Jun Fujii Kozo Fujisaki Eriko Fujita Mitsunori Fukuda Ruth H Furukawa Matthias Gaestel Philippe Gailly Malgorzata Gajewska Brigitte Galliot Vincent Galy Subramaniam Ganesh Barry Ganetzky Ian G Ganley Fen-Biao Gao George F Gao Jinming Gao Lorena Garcia Guillermo Garcia-Manero Mikel Garcia-Marcos Marjan Garmyn Andrei L Gartel Evelina Gatti Mathias Gautel Thomas R Gawriluk Matthew E Gegg Jiefei Geng Marc Germain Jason E Gestwicki David A Gewirtz Saeid Ghavami Pradipta Ghosh Anna M Giammarioli Alexandra N Giatromanolaki Spencer B Gibson Robert W Gilkerson Michael L Ginger Henry N Ginsberg Jakub Golab Michael S Goligorsky Pierre Golstein Candelaria Gomez-Manzano Ebru Goncu Céline Gongora Claudio D Gonzalez Ramon Gonzalez Cristina González-Estévez Rosa Ana González-Polo Elena Gonzalez-Rey Nikolai V Gorbunov Sharon Gorski Sandro Goruppi Roberta A Gottlieb Devrim Gozuacik Giovanna Elvira Granato Gary D Grant Kim N Green Aleš Gregorc Frédéric Gros Charles Grose Thomas W Grunt Philippe Gual Jun-Lin Guan Kun-Liang Guan Sylvie M Guichard Anna S Gukovskaya Ilya Gukovsky Jan Gunst Asa B Gustafsson Andrew J Halayko Amber N Hale Sandra K Halonen Maho Hamasaki Feng Han Ting Han Michael K Hancock Malene Hansen Hisashi Harada Masaru Harada Stefan E Hardt J Wade Harper Adrian L Harris James Harris Steven D Harris Makoto Hashimoto Jeffrey A Haspel Shin-ichiro Hayashi Lori A Hazelhurst Congcong He You-Wen He Marie-Joseé Hébert Kim A Heidenreich Miep H Helfrich Gudmundur V Helgason Elizabeth P Henske Brian Herman Paul K Herman Claudio Hetz Sabine Hilfiker Joseph A Hill Lynne J Hocking Paul Hofman Thomas G Hofmann Jörg Höhfeld Tessa L Holyoake Ming-Huang Hong David A Hood Gökhan S Hotamisligil Ewout J Houwerzijl Maria Høyer-Hansen Bingren Hu Chien-An A Hu Hong-Ming Hu Ya Hua Canhua Huang Ju Huang Shengbing Huang Wei-Pang Huang Tobias B Huber Won-Ki Huh Tai-Ho Hung Ted R Hupp Gang Min Hur James B Hurley Sabah N A Hussain Patrick J Hussey Jung Jin Hwang Seungmin Hwang Atsuhiro Ichihara Shirin Ilkhanizadeh Ken Inoki Takeshi Into Valentina Iovane Juan L Iovanna Nancy Y Ip Yoshitaka Isaka Hiroyuki Ishida Ciro Isidoro Ken-ichi Isobe Akiko Iwasaki Marta Izquierdo Yotaro Izumi Panu M Jaakkola Marja Jäättelä George R Jackson William T Jackson Bassam Janji Marina Jendrach Ju-Hong Jeon Eui-Bae Jeung Hong Jiang Hongchi Jiang Jean X Jiang Ming Jiang Qing Jiang Xuejun Jiang Xuejun Jiang Alberto Jiménez Meiyan Jin Shengkan Jin Cheol O Joe Terje Johansen Daniel E Johnson Gail V W Johnson Nicola L Jones Bertrand Joseph Suresh K Joseph Annie M Joubert Gábor Juhász Lucienne Juillerat-Jeanneret Chang Hwa Jung Yong-Keun Jung Kai Kaarniranta Allen Kaasik Tomohiro Kabuta Motoni Kadowaki Katarina Kagedal Yoshiaki Kamada Vitaliy O Kaminskyy Harm H Kampinga Hiromitsu Kanamori Chanhee Kang Khong Bee Kang Kwang Il Kang Rui Kang Yoon-A Kang Tomotake Kanki Thirumala-Devi Kanneganti Haruo Kanno Anumantha G Kanthasamy Arthi Kanthasamy Vassiliki Karantza Gur P Kaushal Susmita Kaushik Yoshinori Kawazoe Po-Yuan Ke John H Kehrl Ameeta Kelekar Claus Kerkhoff David H Kessel Hany Khalil Jan A K W Kiel Amy A Kiger Akio Kihara Deok Ryong Kim Do-Hyung Kim Dong-Hou Kim Eun-Kyoung Kim Hyung-Ryong Kim Jae-Sung Kim Jeong Hun Kim Jin Cheon Kim John K Kim Peter K Kim Seong Who Kim Yong-Sun Kim Yonghyun Kim Adi Kimchi Alec C Kimmelman Jason S King Timothy J Kinsella Vladimir Kirkin Lorrie A Kirshenbaum Katsuhiko Kitamoto Kaio Kitazato Ludger Klein Walter T Klimecki Jochen Klucken Erwin Knecht Ben C B Ko Jan C Koch Hiroshi Koga Jae-Young Koh Young Ho Koh Masato Koike Masaaki Komatsu Eiki Kominami Hee Jeong Kong Wei-Jia Kong Viktor I Korolchuk Yaichiro Kotake Michael I Koukourakis Juan B Kouri Flores Attila L Kovács Claudine Kraft Dimitri Krainc Helmut Krämer Carole Kretz-Remy Anna M Krichevsky Guido Kroemer Rejko Krüger Oleg Krut Nicholas T Ktistakis Chia-Yi Kuan Roza Kucharczyk Ashok Kumar Raj Kumar Sharad Kumar Mondira Kundu Hsing-Jien Kung Tino Kurz Ho Jeong Kwon Albert R La Spada Frank Lafont Trond Lamark Jacques Landry Jon D Lane Pierre Lapaquette Jocelyn F Laporte Lajos László Sergio Lavandero Josée N Lavoie Robert Layfield Pedro A Lazo Weidong Le Laurent Le Cam Daniel J Ledbetter Alvin J X Lee Byung-Wan Lee Gyun Min Lee Jongdae Lee Ju-Hyun Lee Michael Lee Myung-Shik Lee Sug Hyung Lee Christiaan Leeuwenburgh Patrick Legembre Renaud Legouis Michael Lehmann Huan-Yao Lei Qun-Ying Lei David A Leib José Leiro John J Lemasters Antoinette Lemoine Maciej S Lesniak Dina Lev Victor V Levenson Beth Levine Efrat Levy Faqiang Li Jun-Lin Li Lian Li Sheng Li Weijie Li Xue-Jun Li Yan-bo Li Yi-Ping Li Chengyu Liang Qiangrong Liang Yung-Feng Liao Pawel P Liberski Andrew Lieberman Hyunjung J Lim Kah-Leong Lim Kyu Lim Chiou-Feng Lin Fu-Cheng Lin Jian Lin Jiandie D Lin Kui Lin Wan-Wan Lin Weei-Chin Lin Yi-Ling Lin Rafael Linden Paul Lingor Jennifer Lippincott-Schwartz Michael P Lisanti Paloma B Liton Bo Liu Chun-Feng Liu Kaiyu Liu Leyuan Liu Qiong A Liu Wei Liu Young-Chau Liu Yule Liu Richard A Lockshin Chun-Nam Lok Sagar Lonial Benjamin Loos Gabriel Lopez-Berestein Carlos López-Otín Laura Lossi Michael T Lotze Peter Lőw Binfeng Lu Bingwei Lu Bo Lu Zhen Lu Frédéric Luciano Nicholas W Lukacs Anders H Lund Melinda A Lynch-Day Yong Ma Fernando Macian Jeff P MacKeigan Kay F Macleod Frank Madeo Luigi Maiuri Maria Chiara Maiuri Davide Malagoli May Christine V Malicdan Walter Malorni Na Man Eva-Maria Mandelkow Stéphen Manon Irena Manov Kai Mao Xiang Mao Zixu Mao Philippe Marambaud Daniela Marazziti Yves L Marcel Katie Marchbank Piero Marchetti Stefan J Marciniak Mateus Marcondes Mohsen Mardi Gabriella Marfe Guillermo Mariño Maria Markaki Mark R Marten Seamus J Martin Camille Martinand-Mari Wim Martinet Marta Martinez-Vicente Matilde Masini Paola Matarrese Saburo Matsuo Raffaele Matteoni Andreas Mayer Nathalie M Mazure David J McConkey Melanie J McConnell Catherine McDermott Christine McDonald Gerald M McInerney Sharon L McKenna BethAnn McLaughlin Pamela J McLean Christopher R McMaster G Angus McQuibban Alfred J Meijer Miriam H Meisler Alicia Meléndez Thomas J Melia Gerry Melino Maria A Mena Javier A Menendez Rubem F S Menna-Barreto Manoj B Menon Fiona M Menzies Carol A Mercer Adalberto Merighi Diane E Merry Stefania Meschini Christian G Meyer Thomas F Meyer Chao-Yu Miao Jun-Ying Miao Paul A M Michels Carine Michiels Dalibor Mijaljica Ana Milojkovic Saverio Minucci Clelia Miracco Cindy K Miranti Ioannis Mitroulis Keisuke Miyazawa Noboru Mizushima Baharia Mograbi Simin Mohseni Xavier Molero Bertrand Mollereau Faustino Mollinedo Takashi Momoi Iryna Monastyrska Martha M Monick Mervyn J Monteiro Michael N Moore Rodrigo Mora Kevin Moreau Paula I Moreira Yuji Moriyasu Jorge Moscat Serge Mostowy Jeremy C Mottram Tomasz Motyl Charbel E-H Moussa Sylke Müller Sylviane Muller Karl Münger Christian Münz Leon O Murphy Maureen E Murphy Antonio Musarò Indira Mysorekar Eiichiro Nagata Kazuhiro Nagata Aimable Nahimana Usha Nair Toshiyuki Nakagawa Kiichi Nakahira Hiroyasu Nakano Hitoshi Nakatogawa Meera Nanjundan Naweed I Naqvi Derek P Narendra Masashi Narita Miguel Navarro Steffan T Nawrocki Taras Y Nazarko Andriy Nemchenko Mihai G Netea Thomas P Neufeld Paul A Ney Ioannis P Nezis Huu Phuc Nguyen Daotai Nie Ichizo Nishino Corey Nislow Ralph A Nixon Takeshi Noda Angelika A Noegel Anna Nogalska Satoru Noguchi Lucia Notterpek Ivana Novak Tomoyoshi Nozaki Nobuyuki Nukina Thorsten Nürnberger Beat Nyfeler Keisuke Obara Terry D Oberley Salvatore Oddo Michinaga Ogawa Toya Ohashi Koji Okamoto Nancy L Oleinick F Javier Oliver Laura J Olsen Stefan Olsson Onya Opota Timothy F Osborne Gary K Ostrander Kinya Otsu Jing-hsiung James Ou Mireille Ouimet Michael Overholtzer Bulent Ozpolat Paolo Paganetti Ugo Pagnini Nicolas Pallet Glen E Palmer Camilla Palumbo Tianhong Pan Theocharis Panaretakis Udai Bhan Pandey Zuzana Papackova Issidora Papassideri Irmgard Paris Junsoo Park Ohkmae K Park Jan B Parys Katherine R Parzych Susann Patschan Cam Patterson Sophie Pattingre John M Pawelek Jianxin Peng David H Perlmutter Ida Perrotta George Perry Shazib Pervaiz Matthias Peter Godefridus J Peters Morten Petersen Goran Petrovski James M Phang Mauro Piacentini Philippe Pierre Valérie Pierrefite-Carle Gérard Pierron Ronit Pinkas-Kramarski Antonio Piras Natik Piri Leonidas C Platanias Stefanie Pöggeler Marc Poirot Angelo Poletti Christian Poüs Mercedes Pozuelo-Rubio Mette Prætorius-Ibba Anil Prasad Mark Prescott Muriel Priault Nathalie Produit-Zengaffinen Ann Progulske-Fox Tassula Proikas-Cezanne Serge Przedborski Karin Przyklenk Rosa Puertollano Julien Puyal Shu-Bing Qian Liang Qin Zheng-Hong Qin Susan E Quaggin Nina Raben Hannah Rabinowich Simon W Rabkin Irfan Rahman Abdelhaq Rami Georg Ramm Glenn Randall Felix Randow V Ashutosh Rao Jeffrey C Rathmell Brinda Ravikumar Swapan K Ray Bruce H Reed John C Reed Fulvio Reggiori Anne Régnier-Vigouroux Andreas S Reichert John J Reiners Russel J Reiter Jun Ren José L Revuelta Christopher J Rhodes Konstantinos Ritis Elizete Rizzo Jeffrey Robbins Michel Roberge Hernan Roca Maria C Roccheri Stephane Rocchi H Peter Rodemann Santiago Rodríguez de Córdoba Bärbel Rohrer Igor B Roninson Kirill Rosen Magdalena M Rost-Roszkowska Mustapha Rouis Kasper M A Rouschop Francesca Rovetta Brian P Rubin David C Rubinsztein Klaus Ruckdeschel Edmund B Rucker Assaf Rudich Emil Rudolf Nelson Ruiz-Opazo Rossella Russo Tor Erik Rusten Kevin M Ryan Stefan W Ryter David M Sabatini Junichi Sadoshima Tapas Saha Tatsuya Saitoh Hiroshi Sakagami Yasuyoshi Sakai Ghasem Hoseini Salekdeh Paolo Salomoni Paul M Salvaterra Guy Salvesen Rosa Salvioli Anthony M J Sanchez José A Sánchez-Alcázar Ricardo Sánchez-Prieto Marco Sandri Uma Sankar Poonam Sansanwal Laura Santambrogio Shweta Saran Sovan Sarkar Minnie Sarwal Chihiro Sasakawa Ausra Sasnauskiene Miklós Sass Ken Sato Miyuki Sato Anthony H V Schapira Michael Scharl Hermann M Schätzl Wiep Scheper Stefano Schiaffino Claudio Schneider Marion E Schneider Regine Schneider-Stock Patricia V Schoenlein Daniel F Schorderet Christoph Schüller Gary K Schwartz Luca Scorrano Linda Sealy Per O Seglen Juan Segura-Aguilar Iban Seiliez Oleksandr Seleverstov Christian Sell Jong Bok Seo Duska Separovic Vijayasaradhi Setaluri Takao Setoguchi Carmine Settembre John J Shacka Mala Shanmugam Irving M Shapiro Eitan Shaulian Reuben J Shaw James H Shelhamer Han-Ming Shen Wei-Chiang Shen Zu-Hang Sheng Yang Shi Kenichi Shibuya Yoshihiro Shidoji Jeng-Jer Shieh Chwen-Ming Shih Yohta Shimada Shigeomi Shimizu Takahiro Shintani Orian S Shirihai Gordon C Shore Andriy A Sibirny Stan B Sidhu Beata Sikorska Elaine C M Silva-Zacarin Alison Simmons Anna Katharina Simon Hans-Uwe Simon Cristiano Simone Anne Simonsen David A Sinclair Rajat Singh Debasish Sinha Frank A Sinicrope Agnieszka Sirko Parco M Siu Efthimios Sivridis Vojtech Skop Vladimir P Skulachev Ruth S Slack Soraya S Smaili Duncan R Smith Maria S Soengas Thierry Soldati Xueqin Song Anil K Sood Tuck Wah Soong Federica Sotgia Stephen A Spector Claudia D Spies Wolfdieter Springer Srinivasa M Srinivasula Leonidas Stefanis Joan S Steffan Ruediger Stendel Harald Stenmark Anastasis Stephanou Stephan T Stern Cinthya Sternberg Björn Stork Peter Strålfors Carlos S Subauste Xinbing Sui David Sulzer Jiaren Sun Shi-Yong Sun Zhi-Jun Sun Joseph J Y Sung Kuninori Suzuki Toshihiko Suzuki Michele S Swanson Charles Swanton Sean T Sweeney Lai-King Sy Gyorgy Szabadkai Ira Tabas Heinrich Taegtmeyer Marco Tafani Krisztina Takács-Vellai Yoshitaka Takano Kaoru Takegawa Genzou Takemura Fumihiko Takeshita Nicholas J Talbot Kevin S W Tan Keiji Tanaka Kozo Tanaka Daolin Tang Dingzhong Tang Isei Tanida Bakhos A Tannous Nektarios Tavernarakis Graham S Taylor Gregory A Taylor J Paul Taylor Lance S Terada Alexei Terman Gianluca Tettamanti Karin Thevissen Craig B Thompson Andrew Thorburn Michael Thumm FengFeng Tian Yuan Tian Glauco Tocchini-Valentini Aviva M Tolkovsky Yasuhiko Tomino Lars Tönges Sharon A Tooze Cathy Tournier John Tower Roberto Towns Vladimir Trajkovic Leonardo H Travassos Ting-Fen Tsai Mario P Tschan Takeshi Tsubata Allan Tsung Boris Turk Lorianne S Turner Suresh C Tyagi Yasuo Uchiyama Takashi Ueno Midori Umekawa Rika Umemiya-Shirafuji Vivek K Unni Maria I Vaccaro Enza Maria Valente Greet Van den Berghe Ida J van der Klei Wouter van Doorn Linda F van Dyk Marjolein van Egmond Leo A van Grunsven Peter Vandenabeele Wim P Vandenberghe Ilse Vanhorebeek Eva C Vaquero Guillermo Velasco Tibor Vellai Jose Miguel Vicencio Richard D Vierstra Miquel Vila Cécile Vindis Giampietro Viola Maria Teresa Viscomi Olga V Voitsekhovskaja Clarissa von Haefen Marcela Votruba Keiji Wada Richard Wade-Martins Cheryl L Walker Craig M Walsh Jochen Walter Xiang-Bo Wan Aimin Wang Chenguang Wang Dawei Wang Fan Wang Fen Wang Guanghui Wang Haichao Wang Hong-Gang Wang Horng-Dar Wang Jin Wang Ke Wang Mei Wang Richard C Wang Xinglong Wang Xuejun Wang Ying-Jan Wang Yipeng Wang Zhen Wang Zhigang Charles Wang Zhinong Wang Derick G Wansink Diane M Ward Hirotaka Watada Sarah L Waters Paul Webster Lixin Wei Conrad C Weihl William A Weiss Scott M Welford Long-Ping Wen Caroline A Whitehouse J Lindsay Whitton Alexander J Whitworth Tom Wileman John W Wiley Simon Wilkinson Dieter Willbold Roger L Williams Peter R Williamson Bradly G Wouters Chenghan Wu Dao-Cheng Wu William K K Wu Andreas Wyttenbach Ramnik J Xavier Zhijun Xi Pu Xia Gengfu Xiao Zhiping Xie Zhonglin Xie Da-zhi Xu Jianzhen Xu Liang Xu Xiaolei Xu Ai Yamamoto Akitsugu Yamamoto Shunhei Yamashina Michiaki Yamashita Xianghua Yan Mitsuhiro Yanagida Dun-Sheng Yang Elizabeth Yang Jin-Ming Yang Shi Yu Yang Wannian Yang Wei Yuan Yang Zhifen Yang Meng-Chao Yao Tso-Pang Yao Behzad Yeganeh Wei-Lien Yen Jia-jing Yin Xiao-Ming Yin Ook-Joon Yoo Gyesoon Yoon Seung-Yong Yoon Tomohiro Yorimitsu Yuko Yoshikawa Tamotsu Yoshimori Kohki Yoshimoto Ho Jin You Richard J Youle Anas Younes Li Yu Long Yu Seong-Woon Yu Wai Haung Yu Zhi-Min Yuan Zhenyu Yue Cheol-Heui Yun Michisuke Yuzaki Olga Zabirnyk Elaine Silva-Zacarin David Zacks Eldad Zacksenhaus Nadia Zaffaroni Zahra Zakeri Herbert J Zeh Scott O Zeitlin Hong Zhang Hui-Ling Zhang Jianhua Zhang Jing-Pu Zhang Lin Zhang Long Zhang Ming-Yong Zhang Xu Dong Zhang Mantong Zhao Yi-Fang Zhao Ying Zhao Zhizhuang J Zhao Xiaoxiang Zheng Boris Zhivotovsky Qing Zhong Cong-Zhao Zhou Changlian Zhu Wei-Guo Zhu Xiao-Feng Zhu Xiongwei Zhu Yuangang Zhu Teresa Zoladek Wei-Xing Zong Antonio Zorzano Jürgen Zschocke Brian Zuckerbraun

Autophagy 2012 Apr;8(4):445-544

Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.

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April 2012

Recombinant peptide constructs for targeted cell penetrating peptide-mediated delivery.

Authors:
Jennica L Zaro Likun Fei Wei-Chiang Shen

J Control Release 2012 Mar 1;158(3):357-61. Epub 2012 Feb 1.

Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, 1985 Zonal Ave, Los Angeles, CA 90033, United States.

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March 2012

Comparison of cationic and amphipathic cell penetrating peptides for siRNA delivery and efficacy.

Authors:
Robert H Mo Jennica L Zaro Wei-Chiang Shen

Mol Pharm 2012 Feb 28;9(2):299-309. Epub 2011 Dec 28.

Department of Pharmacology and Pharmaceutical Sciences, University of Southern California School of Pharmacy, Los Angeles, California 90033, USA.

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February 2012

Receptor-mediated activation of a proinsulin-transferrin fusion protein in hepatoma cells.

Authors:
Yan Wang Yu-Sheng Chen Jennica L Zaro Wei-Chiang Shen

J Control Release 2011 Nov 2;155(3):386-92. Epub 2011 Jul 2.

Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, United States.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196267PMC
November 2011

The influence of net charge and charge distribution on cellular uptake and cytosolic localization of arginine-rich peptides.

Authors:
Likun Fei Ling Ren Jennica L Zaro Wei-Chiang Shen

J Drug Target 2011 Sep 9;19(8):675-80. Epub 2010 Dec 9.

Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA.

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http://dx.doi.org/10.3109/1061186X.2010.531729DOI Listing
September 2011

Fast preparation of fungal DNA for PCR screening.

Authors:
Kuang-Hung Liu Yu-Ling Yeh Wei-Chiang Shen

J Microbiol Methods 2011 May 17;85(2):170-2. Epub 2011 Feb 17.

Department of Plant Pathology and Microbiology, National Taiwan University, Taipei, Taiwan.

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http://dx.doi.org/10.1016/j.mimet.2011.01.029DOI Listing
May 2011

Arsenite-oxidizing and arsenate-reducing bacteria associated with arsenic-rich groundwater in Taiwan.

Authors:
Vivian Hsiu-Chuan Liao Yu-Ju Chu Yu-Chen Su Sung-Yun Hsiao Chia-Cheng Wei Chen-Wuing Liu Chung-Min Liao Wei-Chiang Shen Fi-John Chang

J Contam Hydrol 2011 Apr 21;123(1-2):20-9. Epub 2010 Dec 21.

Department of Bioenvironmental Systems Engineering, National Taiwan University, 1 Roosevelt Road, Sec. 4, Taipei 106, Taiwan.

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April 2011

Effects of receptor binding on plasma half-life of bifunctional transferrin fusion proteins.

Authors:
Xiaoying Chen Hsin-Fang Lee Jennica L Zaro Wei-Chiang Shen

Mol Pharm 2011 Apr 22;8(2):457-65. Epub 2011 Feb 22.

Department of Pharmacology and Pharmaceutical Sciences, University of Southern California School of Pharmacy, Los Angeles, California 90089-9121, USA.

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April 2011

Cryptococcus neoformans mediator protein Ssn8 negatively regulates diverse physiological processes and is required for virulence.

Authors:
Lin-Ing Wang Yu-Sheng Lin Kung-Hung Liu Ambrose Y Jong Wei-Chiang Shen

PLoS One 2011 Apr 29;6(4):e19162. Epub 2011 Apr 29.

Department of Plant Pathology and Microbiology, National Taiwan University, Taipei, Taiwan.

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April 2011

Mating differentiation in Cryptococcus neoformans is negatively regulated by the Crk1 protein kinase.

Authors:
Kuang-Hung Liu Wei-Chiang Shen

Fungal Genet Biol 2011 Mar 24;48(3):225-40. Epub 2010 Nov 24.

Department of Plant Pathology and Microbiology, National Taiwan University, No. 1 Roosevelt Road, Taipei, Taiwan.

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March 2011

Design of an in vivo cleavable disulfide linker in recombinant fusion proteins.

Authors:
Xiaoying Chen Yun Bai Jennica L Zaro Wei-Chiang Shen

Biotechniques 2010 Jul;49(1):513-8

Department of Pharmacology and Pharmaceutical Sciences, University of Southern California School of Pharmacy, Los Angeles, CA 90089, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111088PMC
July 2010

Human growth hormone-transferrin fusion protein for oral delivery in hypophysectomized rats.

Authors:
Nurmamet Amet Wei Wang Wei-Chiang Shen

J Control Release 2010 Jan 15;141(2):177-82. Epub 2009 Sep 15.

Department of Pharmacology and Pharmaceutical Sciences, University of Southern California School of Pharmacy, PSC 404B, 1985 Zonal Avenue, Los Angeles, CA 90089-9121, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815093PMC
January 2010

Conjugation with cationic cell-penetrating peptide increases pulmonary absorption of insulin.

Authors:
Leena N Patel Jeffrey Wang Kwang-Jin Kim Zea Borok Edward D Crandall Wei-Chiang Shen

Mol Pharm 2009 Mar-Apr;6(2):492-503

Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, Will Rogers Institute Pulmonary Research Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089-9121, USA.

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September 2009

Nuclear localization of cell-penetrating peptides is dependent on endocytosis rather than cytosolic delivery in CHO cells.

Authors:
Jennica L Zaro Jacqueline E Vekich Thuy Tran Wei-Chiang Shen

Mol Pharm 2009 Mar-Apr;6(2):337-44

Department of Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, PSC 404B, Los Angeles, California 90033-1039, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638978PMC
September 2009

Phylogenetic study of two truffles, Tuber formosanum and Tuber furfuraceum, identified from Taiwan.

Authors:
Jing-Yang Huang Hung-Tao Hu Wei-Chiang Shen

FEMS Microbiol Lett 2009 May 1;294(2):157-71. Epub 2009 Apr 1.

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May 2009

Insertion of the designed helical linker led to increased expression of tf-based fusion proteins.

Authors:
Nurmamet Amet Hsin-Fang Lee Wei-Chiang Shen

Pharm Res 2009 Mar 11;26(3):523-8. Epub 2008 Nov 11.

Department of Pharmacology and Pharmaceutical Sciences, University of Southern California School of Pharmacy, PSC 404B, 1985 Zonal Avenue, Los Angeles, California, 90089-9121, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121561PMC
March 2009

Disulfide and thioether linked cytochrome c-oligoarginine conjugates in HeLa cells.

Authors:
Maureen P Barnes Wei-Chiang Shen

Int J Pharm 2009 Mar 19;369(1-2):79-84. Epub 2008 Nov 19.

University of Southern California, School of Pharmacy, Department of Pharmacology and Pharmaceutical Sciences, Los Angeles, CA 90033, United States.

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March 2009

A screening for suppressor mutants reveals components involved in the blue light-inhibited sexual filamentation in Cryptococcus neoformans.

Authors:
Yu-Ling Yeh Yu-Sheng Lin Bei-Jia Su Wei-Chiang Shen

Fungal Genet Biol 2009 Jan 25;46(1):42-54. Epub 2008 Oct 25.

Department of Plant Pathology and Microbiology, National Taiwan University, Room 216, Building Number 1, No. 1 Roosevelt Road, Sec. 4, 10617 Taipei, Taiwan.

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January 2009

Reversible lipidization of somatostatin analogues for the liver targeting.

Authors:
Liyun Yuan Jeff Wang Wei-Chiang Shen

Eur J Pharm Biopharm 2008 Oct 17;70(2):615-20. Epub 2008 May 17.

Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90089, USA.

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http://dx.doi.org/10.1016/j.ejpb.2008.05.004DOI Listing
October 2008

Characterization of protein factor(s) in rat bronchoalveolar lavage fluid that enhance insulin transport via transcytosis across primary rat alveolar epithelial cell monolayers.

Authors:
Rana Bahhady Kwang-Jin Kim Zea Borok Edward D Crandall Wei-Chiang Shen

Eur J Pharm Biopharm 2008 Aug 6;69(3):808-16. Epub 2008 Feb 6.

Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90089-9121, USA.

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August 2008

Lipidization of human interferon-alpha: a new approach toward improving the delivery of protein drugs.

Authors:
Liyun Yuan Jeff Wang Wei-Chiang Shen

J Control Release 2008 Jul 26;129(1):11-7. Epub 2008 Mar 26.

Department of Pharmacology and Pharmaceutical Sciences, University of Southern, California, Los Angeles, CA 90089, USA.

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http://dx.doi.org/10.1016/j.jconrel.2008.03.014DOI Listing
July 2008

Molecular and functional expression of multidrug resistance-associated protein-1 in primary cultured rat alveolar epithelial cells.

Authors:
Leena N Patel Tomomi Uchiyama Kwang-Jin Kim Zea Borok Edward D Crandall Wei-Chiang Shen Vincent H L Lee

J Pharm Sci 2008 Jun;97(6):2340-9

Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, California 90089-9121, USA.

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http://dx.doi.org/10.1002/jps.21134DOI Listing
June 2008

Tyrphostin A8 stimulates a novel trafficking pathway of apically endocytosed transferrin through Rab11-enriched compartments in Caco-2 cells.

Authors:
Fariba Norouziyan Wei-Chiang Shen Sarah F Hamm-Alvarez

Am J Physiol Cell Physiol 2008 Jan 24;294(1):C7-21. Epub 2007 Oct 24.

Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, California 90033, USA.

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http://dx.doi.org/10.1152/ajpcell.00372.2006DOI Listing
January 2008

Cell penetrating peptides: intracellular pathways and pharmaceutical perspectives.

Authors:
Leena N Patel Jennica L Zaro Wei-Chiang Shen

Pharm Res 2007 Nov 19;24(11):1977-92. Epub 2007 Apr 19.

Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California 90089, USA.

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November 2007

Accumulation of transferrin in Caco-2 cells: a possible mechanism of intestinal transferrin absorption.

Authors:
Ching-Jou Lim Fariba Norouziyan Wei-Chiang Shen

J Control Release 2007 Oct 11;122(3):393-8. Epub 2007 Apr 11.

Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90033, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2128747PMC
October 2007

Enhancement of insulin transport across primary rat alveolar epithelial cell monolayers by endogenous cellular factor(s).

Authors:
Rana Bahhady Kwang-Jin Kim Zea Borok Edward D Crandall Wei-Chiang Shen

Pharm Res 2007 Sep 19;24(9):1713-9. Epub 2007 Apr 19.

Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, California 90089-9121, USA.

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September 2007

Improving the oral efficacy of recombinant granulocyte colony-stimulating factor and transferrin fusion protein by spacer optimization.

Authors:
Yun Bai Wei-Chiang Shen

Pharm Res 2006 Sep 9;23(9):2116-21. Epub 2006 Aug 9.

Department of Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California 90033, USA.

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http://dx.doi.org/10.1007/s11095-006-9059-5DOI Listing
September 2006

Membrane transduction of oligoarginine in HeLa cells is not mediated by macropinocytosis.

Authors:
Jennica L Zaro Thejani E Rajapaksa Curtis T Okamoto Wei-Chiang Shen

Mol Pharm 2006 Mar-Apr;3(2):181-6

Department of Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California 90033-1039, USA.

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http://dx.doi.org/10.1021/mp0500869DOI Listing
June 2006

Drug evaluation: ADI-PEG-20--a PEGylated arginine deiminase for arginine-auxotrophic cancers.

Authors:
Li-Jiuan Shen Wei-Chiang Shen

Curr Opin Mol Ther 2006 Jun;8(3):240-8

School of Pharmacy, College of Medicine, National Taiwan University, 12F 1 Ren-Ai Road, Sec 1, Taipei 100, Taiwan.

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June 2006

Reversible lipidization for the oral delivery of leu-enkephalin.

Authors:
Jeffrey Wang Derk J Hogenkamp Minhtam Tran Wen-Yen Li Ryan F Yoshimura Timothy B C Johnstone Wei-Chiang Shen Kelvin W Gee

J Drug Target 2006 Apr;14(3):127-36

College of Pharmacy, Western University of Health Sciences, Department of Pharmaceutical Sciences, Pomona, CA 91766, USA. jwangwesternu.edu

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http://dx.doi.org/10.1080/10611860600648221DOI Listing
April 2006

Modulation of arginine metabolic pathways as the potential anti-tumor mechanism of recombinant arginine deiminase.

Authors:
Li-Jiuan Shen Karin Beloussow Wei-Chiang Shen

Cancer Lett 2006 Jan;231(1):30-5

Department of Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, 404B, Los Angeles, CA 90089-9121, USA.

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http://dx.doi.org/10.1016/j.canlet.2005.01.007DOI Listing
January 2006

Cytosolic delivery of a p16-peptide oligoarginine conjugate for inhibiting proliferation of MCF7 cells.

Authors:
Jennica L Zaro Wei-Chiang Shen

J Control Release 2005 Nov 3;108(2-3):409-17. Epub 2005 Oct 3.

University of Southern California, School of Pharmacy, Department of Pharmaceutical Sciences, 1985 Zonal Avenue, PSC 404B, Los Angeles, CA 90033-1039, USA.

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http://dx.doi.org/10.1016/j.jconrel.2005.08.028DOI Listing
November 2005

Comparison of monomeric and oligomeric transferrin as potential carrier in oral delivery of protein drugs.

Authors:
Ching-Jou Lim Wei-Chiang Shen

J Control Release 2005 Sep;106(3):273-86

Department of Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA.

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http://dx.doi.org/10.1016/j.jconrel.2005.05.001DOI Listing
September 2005

Evidence that membrane transduction of oligoarginine does not require vesicle formation.

Authors:
Jennica L Zaro Wei-Chiang Shen

Exp Cell Res 2005 Jul 29;307(1):164-73. Epub 2005 Mar 29.

University of Southern California, School of Pharmacy, Department of Pharmaceutical Sciences, 1985 Zonal Avenue, PSC 404B, Los Angeles, CA 90033-1039, USA.

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http://dx.doi.org/10.1016/j.yexcr.2005.02.024DOI Listing
July 2005

Recombinant granulocyte colony-stimulating factor-transferrin fusion protein as an oral myelopoietic agent.

Authors:
Yun Bai David K Ann Wei-Chiang Shen

Proc Natl Acad Sci U S A 2005 May 3;102(20):7292-6. Epub 2005 May 3.

Department of Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA.

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http://dx.doi.org/10.1073/pnas.0500062102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1129103PMC
May 2005

Blue light negatively regulates the sexual filamentation via the Cwc1 and Cwc2 proteins in Cryptococcus neoformans.

Authors:
Ying-Ku Lu Kai-Hui Sun Wei-Chiang Shen

Mol Microbiol 2005 Apr;56(2):480-91

Department of Plant Pathology and Microbiology, National Taiwan University, 106 Taipei, Taiwan.

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http://dx.doi.org/10.1111/j.1365-2958.2005.04549.xDOI Listing
April 2005

Reversible lipidization prolongs the pharmacological effect, plasma duration, and liver retention of octreotide.

Authors:
Liyun Yuan Jeff Wang Wei-Chiang Shen

Pharm Res 2005 Feb;22(2):220-7

Department of Pharmaceutical Sciences, University of Southern California, Los Angeles, California 90033, USA.

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http://dx.doi.org/10.1007/s11095-004-1189-zDOI Listing
February 2005

Accessibility of endothelial and inducible nitric oxide synthase to the intracellular citrulline-arginine regeneration pathway.

Authors:
Li-Jiuan Shen Karin Beloussow Wei-Chiang Shen

Biochem Pharmacol 2005 Jan;69(1):97-104

Department of Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, 404B Los Angeles, CA 90089-9121, USA.

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http://dx.doi.org/10.1016/j.bcp.2004.09.003DOI Listing
January 2005

A homolog of Ste6, the a-factor transporter in Saccharomyces cerevisiae, is required for mating but not for monokaryotic fruiting in Cryptococcus neoformans.

Authors:
Yen-Ping Hsueh Wei-Chiang Shen

Eukaryot Cell 2005 Jan;4(1):147-55

Department of Plant Pathology and Microbiology, National Taiwan University, Taipei, Taiwan.

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http://dx.doi.org/10.1128/EC.4.1.147-155.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC544149PMC
January 2005

Transferrin-oligomers as potential carriers in anticancer drug delivery.

Authors:
Ching-Jou Lim Wei-Chiang Shen

Pharm Res 2004 Nov;21(11):1985-92

Department of Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angles, California 90089, USA.

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http://dx.doi.org/10.1023/b:pham.0000048188.69785.94DOI Listing
November 2004

The transepithelial transport of a G-CSF-transferrin conjugate in Caco-2 cells and its myelopoietic effect in BDF1 mice.

Authors:
Adam Widera Yun Bai Wei-Chiang Shen

Pharm Res 2004 Feb;21(2):278-84

Department of Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California 90033, USA.

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http://dx.doi.org/10.1023/b:pham.0000016240.81059.ecDOI Listing
February 2004

Effects of spermine-conjugated Bowman-Birk inhibitor (spermine-BBI) on carcinogenesis and cholesterol biosynthesis in mice.

Authors:
Ann R Kennedy David Kritchevsky Wei-Chiang Shen

Pharm Res 2003 Dec;20(12):1908-10

Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1023/b:pham.0000008035.02046.cbDOI Listing
December 2003

Recombinant arginine deiminase as a differential modulator of inducible (iNOS) and endothelial (eNOS) nitric oxide synthetase activity in cultured endothelial cells.

Authors:
Li-Jiuan Shen Wen-Chun Lin Karin Beloussow Ken-Ichi Hosoya Tetsuya Terasaki David K Ann Wei-Chiang Shen

Biochem Pharmacol 2003 Nov;66(10):1945-52

Department of Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 1985 Zonal Avenue 404B, Los Angeles, CA 90089-9121, USA.

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http://dx.doi.org/10.1016/s0006-2952(03)00555-0DOI Listing
November 2003

Transcytosis of GCSF-transferrin across rat alveolar epithelial cell monolayers.

Authors:
Adam Widera Kwang-Jin J Kim Edward D Crandall Wei-Chiang Shen

Pharm Res 2003 Aug;20(8):1231-8

Department of Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California 90033, USA.

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http://dx.doi.org/10.1023/a:1025005232421DOI Listing
August 2003

Quantitative comparison of membrane transduction and endocytosis of oligopeptides.

Authors:
Jennica L Zaro Wei-Chiang Shen

Biochem Biophys Res Commun 2003 Jul;307(2):241-7

Department of Pharmaceutical Sciences, University of Southern California, School of Pharmacy, Los Angeles, CA 90033-9121, USA.

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http://dx.doi.org/10.1016/s0006-291x(03)01167-7DOI Listing
July 2003

Oral peptide and protein delivery: unfulfilled promises?

Authors:
Wei-Chiang Shen

Drug Discov Today 2003 Jul;8(14):607-8

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http://dx.doi.org/10.1016/s1359-6446(03)02692-8DOI Listing
July 2003

Resistance to the anti-proliferative activity of recombinant arginine deiminase in cell culture correlates with the endogenous enzyme, argininosuccinate synthetase.

Authors:
Li-Jiuan Shen Wen-Chun Lin Karin Beloussow Wei-Chiang Shen

Cancer Lett 2003 Mar;191(2):165-70

Department of Pharmaceutical Sciences, University of Southern California School of Pharmacy, PSC 404B, 1985 Zonal Avenue, Los Angeles, CA 90089-9121, USA.

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http://dx.doi.org/10.1016/s030-43835(02)00693-6DOI Listing
March 2003

Reversible lipidization for the oral delivery of salmon calcitonin.

Authors:
Jeff Wang Donald Chow Hashem Heiati Wei-Chiang Shen

J Control Release 2003 Mar;88(3):369-80

Department of Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Room 404B, 1985 Zonal Avenue, Los Angeles, CA 90033, USA.

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http://dx.doi.org/10.1016/s0168-3659(03)00008-7DOI Listing
March 2003

Recombinant arginine deiminase as a potential anti-angiogenic agent.

Authors:
Karin Beloussow Li Wang Jun Wu David Ann Wei Chiang Shen

Cancer Lett 2002 Sep;183(2):155-62

Department of Pharmaceutical Sciences, University of Southern California School of Pharmacy, PSC 404B, 1985 Zonal Avenue, Los Angeles, CA 90089-9121, USA.

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http://dx.doi.org/10.1016/s0304-3835(01)00793-5DOI Listing
September 2002

Pulmonary drug delivery.

Authors:
Wei-Chiang Shen

IDrugs 2002 Sep;5(9):908-9

University of Southern California School of Pharmacy, Los Angeles 90033, USA.

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September 2002

Pheromones stimulate mating and differentiation via paracrine and autocrine signaling in Cryptococcus neoformans.

Authors:
Wei-Chiang Shen Robert C Davidson Gary M Cox Joseph Heitman

Eukaryot Cell 2002 Jun;1(3):366-77

Department of Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC118021PMC
http://dx.doi.org/10.1128/ec.1.3.366-377.2002DOI Listing
June 2002

Structure-activity relationship of reversibly lipidized peptides: studies of fatty acid-desmopressin conjugates.

Authors:
Jeff Wang Daphne Wu Wei-Chiang Shen

Pharm Res 2002 May;19(5):609-14

Department of Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles 90033, USA.

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http://dx.doi.org/10.1023/a:1015397811161DOI Listing
May 2002