Publications by authors named "Wei Xia"

1,054 Publications

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Effect of fixed-time artificial insemination on corpus luteum gene expression at the day 16 and 25 pregnancy of gilt.

Anim Biotechnol 2021 May 3:1-9. Epub 2021 May 3.

College of Animal Science and Technology, Hebei Agricultural University, Baoding, China.

Utilization of female livestock can be optimized by application of Fixed-Time Artificial Insemination (FTAI), which plays an important role in large-scale livestock production. However, molecular mechanism of FTAI affecting reproductive performance remains unclear. To investigate the effects of FTAI on corpus luteum in 16 and 25 days of pregnancy gilts, 12 pregnancy gilts were selected from Altrenogest + PMSG + GnRH (APG) group and control group. The number of left and right CL in APG group were significantly higher than control ( < 0.05). Furthermore, result showed the number of differentially expressed genes between 16APG group and 16 C group was obviously larger than that between 25APG and 25 C group (2394 vs. 1476). Up regulated genes in APG were mainly associated with cytokine production and secretion, cell communication and transport (day 16) and angiogenesis, cell cycle and cell-cell signaling (day 25). The expression of differentially expressed genes (RPL10, CYP17A1, DCN, IL18, LDLR and PRLR) in luteal tissue were verified by real-time PCR. In summary, APG program significantly improve reproductive efficiency of gilts through up regulation of cytokine production/secretion, cell communication and transport in Day 16 pregnancy and angiogenesis, cell cycle and cell-cell signaling at Day 25 pregnancy in porcine.
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http://dx.doi.org/10.1080/10495398.2021.1914068DOI Listing
May 2021

Comparative Study of Technologies for Tubule Occlusion and Treatment of Dentin Hypersensitivity.

J Funct Biomater 2021 Apr 27;12(2). Epub 2021 Apr 27.

Department of Materials Science and Engineering, Division of Applied Materials Science, Uppsala University, 751 21 Uppsala, Sweden.

This study aimed to evaluate the occluding/remineralization performance and resistance to acid attacks of the mineralization layer formed by a tooth-desensitizing gel containing amorphous calcium magnesium phosphate (ACMP) particles and compare it to six other desensitizing products available on the market. Similar comprehensive studies are few and there is especially a lack of studies that are up to date. A dentin-disc model was used for in vitro evaluation of the desensitizing toothpastes/gels. Application of the products was performed twice daily for seven days. One set of specimens were evaluated using scanning electron microscopy (SEM) directly after the final treatment and another set was evaluated after an acid challenge, exposing specimens to 2 wt% citric acid. The ACMP desensitizing gel was the only product resulting in complete occlusion by the formation of mineralized material on the dentin surface and inside the tubules. Particle deposition was dominant after treatment with the other desensitizing products, with little or no mineralization, resulting in partial occlusion only. Sensodyne Repair & Protect and Oral-B Pro-Expert showed the highest resistance toward acid attacks. Material inside the tubules remained relatively unaffected by acid attacks in all specimens. The results in this study indicated a great variability among the occluding agents in terms of occlusion and acid resistance of the mineralization layer. The high degree of occlusion and intra-tubular mineralization that could mitigate the effect of acid solubilization indicate that the ACMP desensitizing gel may be a superior option for the treatment of dentin hypersensitivity.
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http://dx.doi.org/10.3390/jfb12020027DOI Listing
April 2021

A Pilot Metabolomic Study on Myocardial Injury Caused by Chronic Alcohol Consumption-Alcoholic Cardiomyopathy.

Molecules 2021 Apr 9;26(8). Epub 2021 Apr 9.

Department of Forensic Pathology, School of Forensic Medicine, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang 110122, China.

Chronic alcohol consumption leads to myocardial injury, ventricle dilation, and cardiac dysfunction, which is defined as alcoholic cardiomyopathy (ACM). To explore the induced myocardial injury and underlying mechanism of ACM, the Liber-DeCarli liquid diet was used to establish an animal model of ACM and histopathology, echocardiography, molecular biology, and metabolomics were employed. Hematoxylin-eosin and Masson's trichrome staining revealed disordered myocardial structure and local fibrosis in the ACM group. Echocardiography revealed thinning wall and dilation of the left ventricle and decreased cardiac function in the ACM group, with increased serum levels of brain natriuretic peptide (BNP) and expression of myocardial BNP mRNA measured through enzyme-linked immunosorbent assay and real-time quantitative polymerase chain reaction (PCR), respectively. Through metabolomic analysis of myocardium specimens, 297 differentially expressed metabolites were identified which were involved in KEGG pathways related to the biosynthesis of unsaturated fatty acids, vitamin digestion and absorption, oxidative phosphorylation, pentose phosphate, and purine and pyrimidine metabolism. The present study demonstrated chronic alcohol consumption caused disordered cardiomyocyte structure, thinning and dilation of the left ventricle, and decreased cardiac function. Metabolomic analysis of myocardium specimens and KEGG enrichment analysis further demonstrated that several differentially expressed metabolites and pathways were involved in the ACM group, which suggests potential causes of myocardial injury due to chronic alcohol exposure and provides insight for further research elucidating the underlying mechanisms of ACM.
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http://dx.doi.org/10.3390/molecules26082177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070378PMC
April 2021

Salivary microbial diversity at different stages of human immunodeficiency virus infection.

Microb Pathog 2021 Apr 26:104913. Epub 2021 Apr 26.

Department of Oral Medicine, Beijing Stomatological Hospital, Capital Medical University, Beijing, 100050, China. Electronic address:

Human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) disrupts the host microbial balance. During disease progression, the oral microbial environment is altered in untreated people living with HIV/AIDS (PLWHA); however, no studies have reported changes in salivary microbial diversity during different stages of HIV infection. Therefore, in this study, we aimed to assess the relationships between immune dysfunction and changes in saliva microbiota. To this end, we collected saliva samples from 11 HIV-negative individuals and 44 PLWHA during different stages based on the Centers for Disease Control and Prevention criteria (stage 0, early stage during the first 6 months after infection; stages 1, 2, and 3 associated with CD4 T-lymphocyte counts of ≥500, 200-499, and ≤200 or opportunistic infection, respectively). We analyzed salivary microbial community diversity using polymerase chain reaction amplification and Illumina MiSeq sequencing. We found that HIV-positive individuals had significantly greater alpha-diversity in the microbial community composition compared with HIV-negative controls (P < 0.05) except for AIDS (stage 3); however, the predominant salivary microbiota in the five groups remained similar. Porphyromonas in the four positive groups was the only genus that was significantly less abundant in the HIV-positive groups than in the control group (P < 0.05). There were some consistencies between the general abundance of salivary microbiota and AIDS disease progression. Lots of bacterial abundances in the saliva increased dramatically during the acute HIV infection (stage 0), and some of the minor and abnormally proliferating bacteria in the asymptomatic stage showed a downward trend. Additionally, in the AIDS stage, partial inhibition was observed. Notably, Porphyromonas was closely related to the immune activation of HIV, showing a decline in abundance once infected with HIV. Solobacterium, which induces inflammation, was negatively correlated with CD4 counts. Overall, our findings provided important insights into changes in salivary microbial diversity in PLWHA.
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http://dx.doi.org/10.1016/j.micpath.2021.104913DOI Listing
April 2021

Effectiveness of smoking cessation interventions for smokers with chronic diseases: A systematic review.

J Adv Nurs 2021 Apr 24. Epub 2021 Apr 24.

School of Nursing, University of Hong Kong, Pokfulam, Hong Kong SAR.

Aims: To systematically summarize seminal studies on the design and effectiveness of smoking cessation interventions targeted at patients with chronic diseases through a critical appraisal of the literature.

Design: A systematic review.

Data Sources: This review included literature identified through a search of six databases up to June 2020.

Review Methods: This review was conducted according to the Cochrane Handbook for Systematic Reviews of Interventions. The literature search was limited to English-language articles on the effectiveness of smoking cessation interventions for smokers who were aged ≥18 years and diagnosed with chronic diseases. Data were extracted using the Cochrane Data collection form for intervention reviews of randomized controlled trials and non-randomized controlled trials. The articles were subjected to a quality assessment.

Results: Ten relevant articles were identified. The designs of the interventions were highly heterogeneous, and only six articles reported a significant increase in smoking abstinence among patients with chronic diseases. In the target population, an intervention delivered by healthcare professionals on an intensive schedule was shown to more effectively induce smoking cessation, compared with minimal counselling. However, methodological flaws were identified in most of the included studies.

Conclusion: The findings of this review suggest that additional efforts are needed to design smoking cessation interventions for patients with chronic diseases and that further examination of the effectiveness and feasibility of these interventions is warranted.

Impact: What problem did the study address? This review evaluated the effectiveness of smoking cessation interventions targeted at patients with chronic diseases. What were the main findings? An intervention with an intensive schedule that was delivered by healthcare professionals was shown to more effectively induce smoking cessation in patients with chronic diseases, compared with minimal counselling. More attention and resources should be directed towards smokers with no intention to quit, especially those with chronic diseases. There is an urgent need for generic smoking cessation interventions that use novel approaches to address the unique needs of this population and to integrate such evidence-based interventions into routine care. Where and on whom will the research have impact? The findings of this review may guide nurses, who play a prominent role in raising the issue of smoking cessation with patients, to design appropriate smoking cessation interventions for patients with chronic diseases. The resulting improvements in patients' health would not only benefit patients themselves but also reduce the burden of chronic diseases on healthcare systems.
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http://dx.doi.org/10.1111/jan.14869DOI Listing
April 2021

Preconceptional and the first trimester exposure to PM and offspring neurodevelopment at 24 months of age: Examining mediation by maternal thyroid hormones in a birth cohort study.

Environ Pollut 2021 Apr 11;284:117133. Epub 2021 Apr 11.

Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, And State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China. Electronic address:

Prenatal fine particulate matter (PM) exposure has been associated with impaired offspring neurodevelopment; however, the association of PM exposure during preconception with offspring's neurodevelopment and factors responsible for this association are still unclear. This study estimated the associations of PM exposure during preconception and the first trimester with offspring neurodevelopment and evaluated whether maternal thyroid hormones mediate these associations. We recruited 1329 mother-child pairs between 2013 and 2015 in Wuhan, China. PM exposure levels of each woman during the 3 months preconception and the first trimester were estimated using land-use regression models. Offspring neurodevelopment characterized by mental developmental index (MDI) and psychomotor developmental index (PDI) were measured at 24 months of age. Maternal serum levels of free thyroxine (FT3), free triiodothyronine (FT4), and thyroid-stimulating hormone (TSH) during early pregnancy were measured of a subset of the 1329 women (551 women). Generalized estimation equation and general linear regression models were used to estimate the associations between maternal PM exposure, thyroid hormones, and offspring neurodevelopment. After adjusting for potential confounders, we found that either among all participants or the subset, PM exposure during preconception and the first trimester was negatively associated with offspring PDI. Double increment in the first trimester PM exposure was significantly associated with 3.43 and 6.48 points decrease in offspring MDI. In the subset, each doubling of PM exposure during preconception and the first trimester was significantly associated with 7.93 and 8.02 points decrease in maternal FT4 level, respectively. Increased maternal FT4, in turn, was associated with increased PDI (β = 16.69, 95% CI: 5.39, 27.99). About 7.7% (95% CI: 2.0%-19.4%) and 8.6% (95% CI: 3.0%, 22.1%) of the effect of PM exposure during preconception on offspring PDI was mediated through maternal FT4 and the FT4/FT3 ratio, respectively.
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http://dx.doi.org/10.1016/j.envpol.2021.117133DOI Listing
April 2021

Injectable tricalcium phosphate/calcium sulfate granule enhances bone repair by reversible setting reaction.

Biochem Biophys Res Commun 2021 Apr 14;557:151-158. Epub 2021 Apr 14.

Department of Engineering Sciences: Applied Materials Sciences, The Ångström Laboratory, SE-751 21, Uppsala, Sweden. Electronic address:

Towards repairing bone defects, calcium sulfate and calcium phosphate cement have been recognized as promising bone grafts. However, the current bone cements are generally lack of proper porosity for cell migration and new tissue formation. On the other hand, porous scaffold cannot be delivered by injection, which limits its use its clinical use. Herein, we develop a novel tricalcium phosphate/calcium sulfate granule to overcome the limitations of injectable cements and traditional scaffolds. The biocompatible granule underwent in situ self-setting to form scaffold with porous structure after injection. It contributes to calcium deposition and upregulation of osteogenic genes of mesenchymal stem cells in a time-dependent manner. Within three months, cavitary bone defects of distal rabbit femurs implanted the granules exhibited better bone formation than those with those implanted with autologous bone.
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http://dx.doi.org/10.1016/j.bbrc.2021.03.145DOI Listing
April 2021

Noninvasive prediction of residual disease for advanced high-grade serous ovarian carcinoma by MRI-based radiomic-clinical nomogram.

Eur Radiol 2021 Apr 16. Epub 2021 Apr 16.

Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, 215163, China.

Objectives: To develop a preoperative MRI-based radiomic-clinical nomogram for prediction of residual disease (RD) in patients with advanced high-grade serous ovarian carcinoma (HGSOC).

Methods: In total, 217 patients with advanced HGSOC were enrolled from January 2014 to June 2019 and randomly divided into a training set (n = 160) and a validation set (n = 57). Finally, 841 radiomic features were extracted from each tumor on T2-weighted imaging (T2WI) and contrast-enhanced T1-weighted imaging (CE-T1WI) sequence, respectively. We used two fusion methods, the maximal volume of interest (MV) and the maximal feature value (MF), to fuse the radiomic features of bilateral tumors, so that patients with bilateral tumors have the same kind of radiomic features as patients with unilateral tumors. The radiomic signatures were constructed by using mRMR method and LASSO classifier. Multivariable logistic regression analysis was used to develop a radiomic-clinical nomogram incorporating radiomic signature and conventional clinico-radiological features. The performance of the nomogram was evaluated on the validation set.

Results: In total, 342 tumors from 217 patients were analyzed in this study. The MF-based radiomic signature showed significantly better prediction performance than the MV-based radiomic signature (AUC = 0.744 vs. 0.650, p = 0.047). By incorporating clinico-radiological features and MF-based radiomic signature, radiomic-clinical nomogram showed favorable prediction ability with an AUC of 0.803 in the validation set, which was significantly higher than that of clinico-radiological signature and MF-based radiomic signature (AUC = 0.623, 0.744, respectively).

Conclusions: The proposed MRI-based radiomic-clinical nomogram provides a promising way to noninvasively predict the RD status.

Key Points: • MRI-based radiomic-clinical nomogram is feasible to noninvasively predict residual disease in patients with advanced HGSOC. • The radiomic signature based on MF showed significantly better prediction performance than that based on MV. • The radiomic-clinical nomogram showed a favorable prediction ability with an AUC of 0.803.
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http://dx.doi.org/10.1007/s00330-021-07902-0DOI Listing
April 2021

Optimal gestational weight gain in Chinese pregnant women by Chinese-specific body mass index categories: a multicenter prospective cohort study.

Public Health Nutr 2021 Apr 12:1-26. Epub 2021 Apr 12.

Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.

Objective: To establish optimal gestational weight gain (GWG) in Chinese pregnant women by Chinese-specific body mass index (BMI) categories and compare the new recommendations with the Institute of Medicine (IOM) 2009 guidelines.

Design: Multicenter, prospective cohort study. Unconditional logistic regression analysis was used to evaluate the odds ratios (ORs), 95% confidence intervals (CIs) and the predicted probabilities of adverse pregnancy outcomes. The optimal GWG range was defined as the range that did not exceed a 1% increase from the lowest predicted probability in each pre-pregnancy BMI group.

Setting: From nine cities in mainland China.

Participants: A total of 3731 women with singleton pregnancy were recruited from April 2013 to December 2014.

Results: The optimal GWG (ranges) by Chinese-specific BMI was 15.0 (12.8-17.1), 14.2 (12.1-16.4) and 12.6 (10.4-14.9) kg for underweight, normal weight and overweight pregnant women, respectively. Inappropriate GWG was associated with several adverse pregnancy outcomes. Compared with women gaining weight within our proposed recommendations, women with excessive GWG had higher risk for macrosomia, large for gestational age and cesarean section; whereas those with inadequate GWG had higher risk for low birth weight, small for gestational age and preterm delivery. The comparison between our proposed recommendations and IOM 2009 guidelines showed that our recommendations were comparable with the IOM 2009 guidelines and could well predict the risk of several adverse pregnancy outcomes.

Conclusions: Inappropriate GWG was associated with higher risk of several adverse pregnancy outcomes. Optimal GWG recommendations proposed in the present study could be applied to Chinese pregnant women.
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http://dx.doi.org/10.1017/S1368980021001622DOI Listing
April 2021

Genetic variability of human papillomavirus type 39 based on E6, E7 and L1 genes in Southwest China.

Virol J 2021 Apr 8;18(1):72. Epub 2021 Apr 8.

Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, 610065, Sichuan, People's Republic of China.

Background: Human papillomavirus type 39 associated with genital intraepithelial neoplasia and invasive cancers, has a high prevalence in Southwest China. HPV E6, E7 are two main papillomavirus oncoproteins, closely relate to the function of HPV immortalization, cell transformation, and carcinogenesis. L1 is the major capsid protein, can reflect the replication status of the virus in cells and the progression of cervical lesions. The purpose of this study is to reveal the prevalence of HPV 39 and the genetic polymorphisms of HPV39 based on E6, E7 and L1 gene in southwest China.

Methods: Cell samples were collected by cervical scraped for HPV detecting and typing, and HPV39 positive samples were selected out. Important E6, E7 and L1 genes of HPV39 were sequenced and analyzed for the study of HPV39 genetic polymorphisms. Phylogenetic trees were constructed by Maximum-likelihood and Kimura 2-parameters methods in Molecular Evolutionary Genetics Analysis version 6.0. The selection pressures of E6, E7 and L1 genes were estimated by Datamonkey web server. The secondary and three-dimensional structure of HPV39 E6, E7 proteins were created by sopma server and SWISS-MODEL software.

Results: 344 HPV39 positive samples were selected from 5718 HPV positive cell samples. Among HPV39 E6-E7 sequences, 20 single nucleotide mutations were detected, including 10 non-synonymous and 10 synonymous mutations; 26 single nucleotide mutations were detected in HPV39 L1 sequences, including 7 non-synonymous and 19 synonymous mutations respectively. 11 novel variants of HPV39 E6-E7 (5 in E6 and 6 in E7) and 14 novel variants of HPV39 L1 were identified in this study. A-branch was the most frequent HPV39 lineage in southwest China during our investigation. Selective pressure analysis showed that codon sites 26, 87, 151 in E6 and 75, 180, 222, 272, 284, 346, 356 in L1 were positively selected sites, as well as codon sites 45, 138, 309, 381 were negative selection sites in L1 gene, E7 has neither positive selection sites nor negative selection sites. A certain degree of secondary and three-dimensional structure dislocation was existed due to the non-synonymous mutations.

Conclusions: Amino acid substitution affected the secondary and three-dimensional structure of HPV39, and resulting in the differences of carcinogenic potential and biological functions as well as the immune response due to the antigen epitopes difference, the antigen epitopes with stronger adaptability in Southwest will be screened out based on the above research results for the later vaccine development. And gene polymorphism of HPV39 in Southwest China may improve the effectiveness of clinical test and vaccine design, specifically for women in Southwest China.
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http://dx.doi.org/10.1186/s12985-021-01528-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027298PMC
April 2021

A Proteomics Study on the Mechanism of Nutmeg-Induced Hepatotoxicity.

Molecules 2021 Mar 20;26(6). Epub 2021 Mar 20.

School of Forensic Medicine, China Medical University, Shenyang 110122, China.

Nutmeg is a traditional spice and medicinal plant with a variety of pharmacological activities. However, nutmeg abuse due to its hallucinogenic characteristics and poisoning cases are frequently reported. Our previous metabolomics study proved the hepatotoxicity of nutmeg and demonstrated that high-dose nutmeg can affect the synthesis and secretion of bile acids and cause oxidative stress. In order to further investigate the hepatotoxicity of nutmeg, normal saline, 1 g/kg, 4 g/kg nutmeg were administrated to male Kunming mice by intragastrical gavage for 7 days. Histopathological investigation of liver tissue, proteomics and biochemical analysis were employed to explore the mechanism of liver damage caused by nutmeg. The results showed that a high-dose (4 g/kg) of nutmeg can cause significant increased level of CYP450s and depletion of antioxidants, resulting in obvious oxidative stress damage and lipid metabolism disorders; but this change was not observed in low-dose group (1 g/kg). In addition, the increased level of malondialdehyde and decreased level of glutathione peroxidase were found after nutmeg exposure. Therefore, the present study reasonably speculates that nutmeg exposure may lead to liver injury through oxidative stress and the degree of this damage is related to the exposure dose.
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http://dx.doi.org/10.3390/molecules26061748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003901PMC
March 2021

A Graphene-Based Stopband FSS with Suppressed Mutual Coupling in Dielectric Resonator Antennas.

Materials (Basel) 2021 Mar 18;14(6). Epub 2021 Mar 18.

Hubei Engineering Research Center of RF-Microwave Technology and Application, Wuhan University of Technology, Wuhan 430070, China.

A novel stopband frequency-selective surface (FSS) made of high-conductivity graphene assemble films (HCGFs) for reducing the mutual coupling between dielectric resonator antennas (DRAs) is investigated and presented. The FSS is a "Hamburg" structure consisting of a two-layer HCGF and a one-layer dielectric substrate. A laser-engraving technology is applied to fabricate the FSS. The proposed improved Jerusalem cross FSS, compared with cross FSS and Jerusalem cross FSS, can effectively reduce the size of the unit cell by 88.89%. Moreover, the FSS, composing of 2 × 10-unit cells along the E-plane, is proposed and embedded between two DRAs, which nearly has no effect on the reflection coefficient of the antenna. However, the mutual coupling is reduced by more than 7 dB on average (7.16 dB at 3.4 GHz, 7.42 dB at 3.5 GHz, 7.71 dB at 3.6 GHz) with the FSS. The patterns of the antenna are also measured. Therefore, it is suggested that the proposed FSS is a good candidate to reduce mutual coupling in the multiple-input-multiple-output (MIMO) antenna system for 5G communication.
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http://dx.doi.org/10.3390/ma14061490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002884PMC
March 2021

One-Dimensional Metal Embedded in Two-Dimensional Semiconductor in NbSiTe.

ACS Nano 2021 Apr 19;15(4):7149-7154. Epub 2021 Mar 19.

School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, China.

The ternary van der Waals material NbSiTe demonstrates many interesting properties as the content of Si is changed, ranging from metallic NbSiTe ( = 5/3) to narrow-gap semiconductor NbSiTe ( = 2) and with the emergence of one-dimensional Dirac fermion excitations in between. An in-depth understanding of their properties with different stoichiometry is important. Here we use scanning tunneling microscopy and spectroscopy to reveal that NbSiTe is a system with spontaneously developed and self-aligned one-dimensional metallic chains embedded in a two-dimensional semiconductor. Electron quasiparticles form one- and two-dimensional standing waves side by side. This special microscopic structure results in strong transport anisotropy. Along the chain direction the material behaves like a metal, while perpendicular to the chain direction, it behaves like a semiconductor. These findings provide an important basis for further investigation of this intriguing system.
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http://dx.doi.org/10.1021/acsnano.1c00320DOI Listing
April 2021

Nanoengineering Metal-Organic Framework-Based Materials for Use in Electrochemical CO Reduction Reactions.

Small 2021 Apr 19;17(16):e2006590. Epub 2021 Mar 19.

School of Chemistry and Molecular Engineering, Shanghai Key Laboratory of Green Chemistry and Chemical Processes, East China Normal University, Shanghai, 200062, China.

Electrocatalytic reduction of carbon dioxide to valuable chemicals is a sustainable technology that can achieve a carbon-neutral energy cycle in the environment. Electrochemical CO  reduction reaction (CO RR) processes using metal-organic frameworks (MOFs), featuring atomically dispersed active sites, large surface area, high porosity, controllable morphology, and remarkable tunability, have attracted considerable research attention. Well-defined MOFs can be constructed to improve conductivity, introduce active centers, and form carbon-based single-atom catalysts (SACs) with enhanced active sites that are accessible for the development of CO  conversion. In this review, the progress on pristine MOFs, MOF hybrids, and MOF-derived carbon-based SACs is summarized for the electrocatalytic reduction of CO . Finally, the limitations and potential improvement directions with respect to the advancement of MOF-related materials for the field of research are discussed. These summaries are expected to provide inspiration on reasonable design to develop stable and high-efficiency MOFs-based electrocatalysts for CO RR.
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http://dx.doi.org/10.1002/smll.202006590DOI Listing
April 2021

Sequential macrophage transition facilitates endogenous bone regeneration induced by Zn-doped porous microcrystalline bioactive glass.

J Mater Chem B 2021 03 15;9(12):2885-2898. Epub 2021 Mar 15.

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.

Macrophages play an important role in the immune microenvironment during bone healing, and sequential macrophage phenotypic transition could achieve superior osteogenic outcomes. Microcrystalline bioactive glasses (MCBGs) with osteoimmunomodulatory effects show potential in bone tissue regeneration. Zinc (Zn) has been approved to coordinate innate and adaptive immunity. Therefore, in this study, different amounts of ZnO were incorporated into microcrystalline bioactive glass to improve its immunomodulatory ability. The effect of Zn-MCBG ionic extracts on macrophage transition was studied, and the 5Zn-MCBG extracts could orchestrate sequential M1-to-M2 macrophage transition and promote the expression of proinflammatory and anti-inflammatory genes and cytokine expression to induce human bone marrow stromal cells (hBMSCs) osteogenic differentiation in vitro. Macroporous Zn-MCBG scaffolds containing mesopores were fabricated and showed good cell adhesion and feasible apatite formation when immersed in SBF in vitro. Furthermore, a rat calvarial defect model was used to confirm that the Zn-MCBG scaffold could modulate macrophage phenotypic transition and create a desirable osteogenic microenvironment to promote osteogenesis in vivo.
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http://dx.doi.org/10.1039/d0tb02884cDOI Listing
March 2021

Multiple-fingerprint analysis of Poria cocos polysaccharide by HPLC combined with chemometrics methods.

J Pharm Biomed Anal 2021 May 6;198:114012. Epub 2021 Mar 6.

Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, China. Electronic address:

In this study, the multiple fingerprints, which were integrated with HPGFC-ELSD (high performance gel filtration chromatography - evaporative light scattering detector) fingerprint, PMP-HPLC-DAD (1-phenyl-3-methyl-5-pyrazolone-high performance liquid chromatography - diode array detector) fingerprint of complete acid hydrolysates and HILIC-HPLC-ELSD (hydrophilic interaction - high performance liquid chromatography - evaporative light scattering detector) fingerprint of enzyme hydrolysates, were established to evaluate the quality of polysaccharides from Poria cocos (PCPs). The similarity evaluation showed that 16 batches of PCPs from different origins had high similarity in structural characteristics based on the multiple fingerprints. The chromatographic data of multiple fingerprints of PCPs were fused, processed and analyzed by chemometric methods including HCA (hierarchical cluster analysis), PCA (principal component analysis) and PLS-DA (partial least squares discriminant analysis). The 16 batches of PCPs were divided into 3 categories in PCA, indicating a certain relationship between the structural characteristics and the origins. PLS-DA analysis indicated that Man, Glc, Gal, Fuc, the components with m/z of 2.22 × 10∼1.53 × 10 Da and 3.46 × 10∼2.69 × 10 Da, oligosaccharides with DPs of 6 and 7, respectively, could be regarded as potential chemical markers for the classification of PCPs from different origins. According to the multiple fingerprints and chemometric analysis, the two commercial samples were proved to be adulterants.
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http://dx.doi.org/10.1016/j.jpba.2021.114012DOI Listing
May 2021

Hierarchical Metal-Polymer Hybrids for Enhanced CO Electroreduction.

Angew Chem Int Ed Engl 2021 May 1;60(19):10977-10982. Epub 2021 Apr 1.

Shanghai Key Laboratory of Green Chemistry and Chemical, Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062, China.

The design of catalysts with high activity, selectivity, and stability is key to the electroreduction of CO . Herein, we report the synthesis of 3D hierarchical metal/polymer-carbon paper (M/polymer-CP) electrodes by in situ electrosynthesis. The 3D polymer layer on CP (polymer-CP) was first prepared by in situ electropolymerization, then a 3D metal layer was decorated on the polymer-CP to produce the M/polymer-CP electrode. Electrodes with different metals (e.g. Cu, Pd, Zn, Sn) and various polymers could be prepared by this method. The electrodes could efficiently reduce CO to desired products, such as C H , CO, and HCOOH, depending on the metal used. For example, C H could be formed with a Faradaic efficiency of 59.4 % and a current density of 30.2 mA cm by using a very stable Cu/PANI-CP electrode in an H-type cell. Control experiments and theoretical calculations showed that the 3D hierarchical structure of the metals and in situ formation of the electrodes are critical for the excellent performance.
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http://dx.doi.org/10.1002/anie.202102193DOI Listing
May 2021

Deep Learning for Automatic Differential Diagnosis of Primary Central Nervous System Lymphoma and Glioblastoma: Multi-Parametric Magnetic Resonance Imaging Based Convolutional Neural Network Model.

J Magn Reson Imaging 2021 Mar 11. Epub 2021 Mar 11.

Academy for Engineering and Technology, Fudan University, Shanghai, China.

Background: Differential diagnosis of primary central nervous system lymphoma (PCNSL) and glioblastoma (GBM) is useful to guide treatment strategies.

Purpose: To investigate the use of a convolutional neural network (CNN) model for differentiation of PCNSL and GBM without tumor delineation.

Study Type: Retrospective.

Population: A total of 289 patients with PCNSL (136) or GBM (153) were included, the average age of the cohort was 54 years, and there were 173 men and 116 women.

Field Strength/sequence: 3.0 T Axial contrast-enhanced T -weighted spin-echo inversion recovery sequence (CE-T WI), T -weighted fluid-attenuation inversion recovery sequence (FLAIR), and diffusion weighted imaging (DWI, b = 0 second/mm , 1000 seconds/mm ).

Assessment: A single-parametric CNN model was built using CE-T WI, FLAIR, and the apparent diffusion coefficient (ADC) map derived from DWI, respectively. A decision-level fusion based multi-parametric CNN model (DF-CNN) was built by combining the predictions of single-parametric CNN models through logistic regression. An image-level fusion based multi-parametric CNN model (IF-CNN) was built using the integrated multi-parametric MR images. The radiomics models were developed. The diagnoses by three radiologists with 6 years (junior radiologist Y.Y.), 11 years (intermediate-level radiologist Y.T.), and 21 years (senior radiologist Y.L.) of experience were obtained.

Statistical Analysis: The 5-fold cross validation was used for model evaluation. The Pearson's chi-squared test was used to compare the accuracies. U-test and Fisher's exact test were used to compare clinical characteristics.

Results: The CE-T WI, FLAIR, and ADC based single-parametric CNN model had accuracy of 0.884, 0.782, and 0.700, respectively. The DF-CNN model had an accuracy of 0.899 which was higher than the IF-CNN model (0.830, P = 0.021), but had no significant difference in accuracy compared to the radiomics model (0.865, P = 0.255), and the senior radiologist (0.906, P = 0.886).

Data Conclusion: A CNN model can differentiate PCNSL from GBM without tumor delineation, and comparable to the radiomics models and radiologists.

Level Of Evidence: 4 TECHNICAL EFFICACY: Stage 2.
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http://dx.doi.org/10.1002/jmri.27592DOI Listing
March 2021

Humanin alleviates insulin resistance in polycystic ovary syndrome: a human and rat model-based study.

Endocrinology 2021 Mar 10. Epub 2021 Mar 10.

Department of Reproduction and Genetics, the First Affiliated Hospital of Kunming Medical University, Kunming, China.

Polycystic ovary syndrome (PCOS), the most common endocrine disorder in women of reproductive age, is characterized by hyperandrogenism and insulin resistance (IR); however, the pathogenesis of local ovarian IR in PCOS remains largely unclear. Humanin, a mitochondria-derived peptide, has been reported to be associated with IR. Our previous study confirmed that humanin is expressed in multiple cell types and is present in follicular fluid. However, it remains unknown whether humanin participates in the pathogenesis of local ovarian IR or whether humanin supplementation can improve IR in PCOS patients. In this study, we compared humanin concentrations in follicular fluid from PCOS patients with and without IR. We further investigated the effect of humanin analogue (HNG) supplementation on IR in a rat model of dehydroepiandrosterone-induced PCOS. Humanin concentrations in the follicular fluid were found to be significantly lower in PCOS patients with IR than in those without IR. HNG supplementation attenuated both the increases in the levels of fasting plasma glucose and fasting insulin in rats with PCOS and the decreases in phosphorylation of IRS1, PI3K, AKT, and GLUT4 proteins in the granulosa cells of these rats. Combined supplementation with HNG and insulin significantly improved glucose consumption in normal and humanin-siRNA-transfected COV434 cells. In conclusion, downregulated humanin in the ovaries may be involved in the pathogenesis of IR in PCOS, and exogenous supplementation with HNG improved local ovarian IR through modulation of the IRS1/PI3K/Akt signaling pathway in a rat model. This finding supports the potential future use of HNG as a therapeutic drug for PCOS.
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http://dx.doi.org/10.1210/endocr/bqab056DOI Listing
March 2021

Fine particulate matter exposure and perturbation of serum metabolome: A longitudinal study in Baoding, China.

Chemosphere 2021 Feb 26;276:130102. Epub 2021 Feb 26.

Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430000, Hubei, PR China; State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430000, Hubei, PR China.

Metabolomics represents a powerful tool for measuring environmental exposures and biological responses to unveil potential mechanisms. Few studies have investigated the effects of exposure to fine particulate matter (PM) longitudinally on serum metabolomics in regions with high-level PM. Therefore, we examined the changes of serum metabolomics corresponding to individual PM exposure levels in spring and autumn among 63 healthy college students in Baoding city, Hebei, China. The metabolic profiling was determined by ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry. The average level of individual PM in the spring was 1.82-fold higher than in the autumn (240 μg/m vs 132 μg/m). Males were exposed to a higher level of PM than females in the spring. Metabolic profiling was clearly separated by orthogonal partial least square-discriminant analysis in males but not in females. In the analysis of the associations between the metabolome and PM of the two seasons, the changes of 14 serum metabolites were significantly associated with PM in males. The metabolites related to heme metabolism (bilirubin, biliverdin), energy metabolism and oxidative stress (2-Octenoylcarnitine, N-Heptanoylglycine, and acetylcysteine), phospholipid metabolism (lysophosphatidic acid, phospholipid acid, and lysophosphatidylethanolamine), and tryptophan metabolism (N-Acetylserotonin, indolepyruvate, and melatonin) were decreased in the range of 2.16%-6.80% for each 10 μg/m increase of PM, while thyrotropin-releasing hormone, glutathione, and phosphatidylethanolamine related to energy metabolism and oxidative stress, and phospholipid metabolism were increased in the range of 2.95%-4.90% for each 10 μg/m increase of PM. This longitudinal study suggests that higher PM exposure may induce perturbations in serum metabolic signaling related to oxidative stress and inflammation, and males may be more prone to these metabolic perturbations.
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http://dx.doi.org/10.1016/j.chemosphere.2021.130102DOI Listing
February 2021

Trimester-specific and sex-specific effects of prenatal exposure to di(2-ethylhexyl) phthalate on fetal growth, birth size, and early-childhood growth: A longitudinal prospective cohort study.

Sci Total Environ 2021 Feb 28;777:146146. Epub 2021 Feb 28.

State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong, China. Electronic address:

Prenatal exposure to di(2-ethylhexyl) phthalate (DEHP) may cause adverse health outcomes. However, trimester-specific impacts of DEHP exposure on offspring growth from fetal to early childhood stage have not been thoroughly evaluated. In this study, participants who provided a full series of urine specimens at three trimesters were selected from a birth cohort conducted at Wuhan, China from 2014 to 2015. 814 mother-offspring pairs were included in the study. Urinary concentrations of DEHP metabolites were determined using liquid chromatography-tandem mass spectrometry. Z-scores for ultrasound-measured fetal growth parameters at 14.0-18.9, 22.6-27.0, and 29.0-33.9 weeks of gestation, were calculated. Weight, height, and body mass index (BMI) at 6, 12, and 24 months were standardized to z-scores using sex-specific and age-specific WHO child growth standards. Linear regressions with generalized estimating equations were used to assess the relationships of DEHP levels per trimester to fetal growth, birth size, and growth at 6, 12, and 24 months to explore the trimester-specific impacts of DEHP exposure on offspring development. Among males, the1-trimester DEHP was negatively related to fetal growth (β < 0, p < 0.05), but positively related to 24-month BMI. The 2nd-trimester DEHP was negatively related to birth weight and birth length, but positively related to weight gain rates from birth to 24 months old. The 3rd-trimester DEHP was positively (β > 0, p < 0.05) associated with birth weight and BMI at 6 and 12 months. Among females, the 1st-trimester DEHP was associated with increased birth length, while the 2nd-trimester DEHP was negatively associated with BMI at 6 and 12 months. A negative association between DEHP and weight gain rates at 6 months was noted among females. This prospective cohort revealed the sex-specific and trimester-specific relationships of DEHP exposure to offspring growth from fetal to early-childhood stage.
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http://dx.doi.org/10.1016/j.scitotenv.2021.146146DOI Listing
February 2021

A Novel Time-Incremental End-to-End Shared Neural Network with Attention-Based Feature Fusion for Multiclass Motor Imagery Recognition.

Comput Intell Neurosci 2021 17;2021:6613105. Epub 2021 Feb 17.

Cixi Institute of Biomedical Engineering, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, Zhejiang 315201, China.

In the research of motor imagery brain-computer interface (MI-BCI), traditional electroencephalogram (EEG) signal recognition algorithms appear to be inefficient in extracting EEG signal features and improving classification accuracy. In this paper, we discuss a solution to this problem based on a novel step-by-step method of feature extraction and pattern classification for multiclass MI-EEG signals. First, the training data from all subjects is merged and enlarged through autoencoder to meet the need for massive amounts of data while reducing the bad effect on signal recognition because of randomness, instability, and individual variability of EEG data. Second, an end-to-end sharing structure with attention-based time-incremental shallow convolution neural network is proposed. Shallow convolution neural network (SCNN) and bidirectional long short-term memory (BiLSTM) network are used to extract frequency-spatial domain features and time-series features of EEG signals, respectively. Then, the attention model is introduced into the feature fusion layer to dynamically weight these extracted temporal-frequency-spatial domain features, which greatly contributes to the reduction of feature redundancy and the improvement of classification accuracy. At last, validation tests using BCI Competition IV 2a data sets show that classification accuracy and kappa coefficient have reached 82.7 ± 5.57% and 0.78 ± 0.074, which can strongly prove its advantages in improving classification accuracy and reducing individual difference among different subjects from the same network.
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http://dx.doi.org/10.1155/2021/6613105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906822PMC
February 2021

Copper Nanoparticles Induce Oxidative Stress via the Heme Oxygenase 1 Signaling Pathway in vitro Studies.

Int J Nanomedicine 2021 26;16:1565-1573. Epub 2021 Feb 26.

Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.

Purpose: The toxicity of copper nanoparticle (CuNP) exposure in the ovaries has attracted attention recently, but the precise molecular mechanism involved requires further investigation. We investigated the cytotoxicity of CuNPs in ovarian granulosa cells and the protective effect of heme oxygenase 1 (HO-1) against CuNP-induced damage.

Methods: Human ovarian granulosa cells (COV434) were treated with CuNPs, and cytotoxicity was evaluated using Cell Counting Kit-8 and flow cytometry assays. Oxidative stress was identified using biochemical markers of oxidation and anti-oxidation. The protein levels of mitogen-activated protein kinase 14 (MAPK14), phospho-MAPK14, nuclear factor erythroid 2-related factor 2 (Nrf2), and HO-1 were measured by immunoblotting. Subsequently, for oxidative stress parameter detection, the cells were pre-treated with hemin to induce HO-1 expression prior to CuNP treatment.

Results: Exposure to CuNPs decreased cell viability and the mitochondrial membrane potential, increased the apoptosis rate, and induced oxidative stress. Furthermore, hemin pretreatment induced HO-1 expression in cells, which partially reduced the accumulation of reactive oxygen species induced by CuNPs and increased the levels of antioxidant enzymes.

Conclusion: CuNPs exert cytotoxic effects on human ovarian granulosa cells by inducing oxidative stress, and may induce HO-1 expression via the MAPK14-Nrf2 signaling pathway. Moreover, HO-1 protects against oxidative stress induced by CuNPs.
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http://dx.doi.org/10.2147/IJN.S292319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7924257PMC
March 2021

Emergence and prevalence of naturally occurring lower virulent African swine fever viruses in domestic pigs in China in 2020.

Sci China Life Sci 2021 Feb 26. Epub 2021 Feb 26.

State Key Laboratory of Veterinary Biotechnology, National High Containment Facilities for Animal Diseases Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China.

African swine fever virus (ASFV) has been circulating in China for more than two years, and it is not clear whether the biological properties of the virus have changed. Here, we report on our surveillance of ASFVs in seven provinces of China, from June to December, 2020. A total of 22 viruses were isolated and characterized as genotype II ASFVs, with mutations, deletions, insertions, or short-fragment replacement occurring in all isolates compared with Pig/HLJ/2018 (HLJ/18), the earliest isolate in China. Eleven isolates had four different types of natural mutations or deletion in the EP402R gene and displayed a non-hemadsorbing (non-HAD) phenotype. Four isolates were tested for virulence in pigs; two were found to be as highly lethal as HLJ/18. However, two non-HAD isolates showed lower virulence but were highly transmissible; infection with 10 TCID dose was partially lethal and caused acute or sub-acute disease, whereas 10 TCID dose caused non-lethal, sub-acute or chronic disease, and persistent infection. The emergence of lower virulent natural mutants brings greater difficulty to the early diagnosis of ASF and creates new challenges for ASFV control.
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http://dx.doi.org/10.1007/s11427-021-1904-4DOI Listing
February 2021

Distribution characteristics of soil particle size in alpine steppe and alpine meadow in the source region of the Yangtze River, China.

Ying Yong Sheng Tai Xue Bao 2021 Feb;32(2):433-440

College of Earth Environmental Sciences, Lanzhou University, Lanzhou 730000, China.

To explore the heterogeneity of spatial distribution and particle size distribution (PSD) in the main underlying surface soil in the source area of the Yangtze River, we used the fractal theory to describe the soil particle size distribution of alpine steppe and alpine meadow, and analyzed the difference of fractal dimension characteristics of soil of two different underlying surface and its relationship with soil particle composition. The results showed that soil particle size in the study area was mainly concentrated in 100-800 μm. The single fractal dimension () of alpine steppe soil was 2.429-2.508, and that of alpine meadow soil was 2.697-2.743. The soil texture of alpine steppe was coarse, while that of alpine meadow soil was fine. Soil texture was the finest in the 20-30 cm depth, and the coarsest in the 0-10 cm layer. The multi-fractal dimension (capacity dimension , information entropy dimension , correlation dimension ) of alpine steppe (0.896-0.961, 0.828-0.887, 0.725-0.819) was higher than that of alpine meadow (0.890-0.914, 0.693-0.744, 0.540-0.603). Compared with the alpine meadow, the alpine steppe had wider soil PSD, more complex soil structure, and higher soil heterogeneity. was positively correlated to clay and silt contents, and negatively correlated to sand content. and were negatively correlated with clay and silt contents, and positively correlated with sand content. Sand content was the main factor accounting for the non-uniform distribution of PSD and the changes of fractal dimension.
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http://dx.doi.org/10.13287/j.1001-9332.202102.010DOI Listing
February 2021

Artificial Intelligence Segmented Dynamic Video Images for Continuity Analysis in the Detection of Severe Cardiovascular Disease.

Front Neurosci 2020 10;14:618481. Epub 2021 Feb 10.

Clinical Medical College, Yangzhou University, Yangzhou, China.

In this paper, an artificial intelligence segmented dynamic video image based on the process of intensive cardiovascular and cerebrovascular disease monitoring is deeply investigated, and a sparse automatic coding deep neural network with a four layers stack structure is designed to automatically extract the deep features of the segmented dynamic video image shot, and six categories of normal, atrial premature, ventricular premature, right bundle branch block, left bundle branch block, and pacing are achieved through hierarchical training and optimization. Accurate recognition of heartbeats with an average accuracy of 99.5%. It provides technical assistance for the intelligent prediction of high-risk cardiovascular diseases like ventricular fibrillation. An intelligent prediction algorithm for sudden cardiac death based on the echolocation network was proposed. By designing an echolocation network with a multilayer serial structure, an intelligent distinction between sudden cardiac death signal and non-sudden death signal was realized, and the signal was predicted 5 min before sudden death occurred, with an average prediction accuracy of 94.32%. Using the self-learning capability of stack sparse auto-coding network, a large amount of label-free data is designed to train the stack sparse auto-coding deep neural network to automatically extract deep representations of plaque features. A small amount of labeled data then introduced to micro-train the entire network. Through the automatic analysis of the fiber cap thickness in the plaques, the automatic identification of thin fiber cap-like vulnerable plaques was achieved, and the average overlap of vulnerable regions reached 87%. The overall time for the automatic plaque and vulnerable plaque recognition algorithm was 0.54 s. It provides theoretical support for accurate diagnosis and endogenous analysis of high-risk cardiovascular diseases.
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http://dx.doi.org/10.3389/fnins.2020.618481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902880PMC
February 2021

Association of fine particulate matter with glucose and lipid metabolism: a longitudinal study in young adults.

Occup Environ Med 2021 Feb 26. Epub 2021 Feb 26.

Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Objectives: This study aimed to evaluate whether PM exposure in a highly polluted area (>100 µg/m) affects glucose and lipid metabolism in healthy adults.

Methods: We recruited 110 healthy adults in Baoding city, Hebei, China, and followed them up between 2017 and 2018. Personal air samplers were used to monitor personal PM levels. Eight glucose and lipid metabolism parameters were quantified. We performed the linear mixed-effect models to investigate the relationships between PM and glucose and lipid metabolism parameters. Stratified analyses were further performed according to sex and body mass index (BMI).

Results: The concentration of PM was the highest in spring, with a median of 232 μg/m and the lowest in autumn (139 μg/m). After adjusting for potential confounders, we found that for each twofold increase in PM, the median of insulin concentration decreased by 5.89% (95% CI -10.91% to -0.58%; p<0.05), and ox-LDL increased by 6.43% (95% CI 2.21% to 10.82%; p<0.05). Stratified analyses indicated that the associations were more pronounced in females, overweight and obese participants.

Conclusions: Exposure to high PM may have deleterious effects on glucose and lipid metabolism. Females, overweight and obese participants are more vulnerable.
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http://dx.doi.org/10.1136/oemed-2020-107039DOI Listing
February 2021

Multiview Subspace Clustering by an Enhanced Tensor Nuclear Norm.

IEEE Trans Cybern 2021 Feb 26;PP. Epub 2021 Feb 26.

Despite the promising preliminary results, tensor-singular value decomposition (t-SVD)-based multiview subspace is incapable of dealing with real problems, such as noise and illumination changes. The major reason is that tensor-nuclear norm minimization (TNNM) used in t-SVD regularizes each singular value equally, which does not make sense in matrix completion and coefficient matrix learning. In this case, the singular values represent different perspectives and should be treated differently. To well exploit the significant difference between singular values, we study the weighted tensor Schatten p-norm based on t-SVD and develop an efficient algorithm to solve the weighted tensor Schatten p-norm minimization (WTSNM) problem. After that, applying WTSNM to learn the coefficient matrix in multiview subspace clustering, we present a novel multiview clustering method by integrating coefficient matrix learning and spectral clustering into a unified framework. The learned coefficient matrix well exploits both the cluster structure and high-order information embedded in multiview views. The extensive experiments indicate the efficiency of our method in six metrics.
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http://dx.doi.org/10.1109/TCYB.2021.3052352DOI Listing
February 2021

The relationship between 2019-nCoV and psychological distress among parents of children with autism spectrum disorder.

Global Health 2021 02 25;17(1):23. Epub 2021 Feb 25.

Department of Children's and Adolescent Health, Public Health College, Harbin Medical University, Harbin, 150081, China.

Objectives: The psychological distress caused by COVID-19 may be pronounced among the parents of children with autism spectrum disorder (ASD). This study aimed to investigate psychological distress among parents of children with ASD during the COVID-19 pandemic.

Methods: A total of 1764 parents of children with ASD and 4962 parents of typically developing (TD) children were recruited. The participants completed an online survey which contained demographic information, the impact due to COVID-19 crisis, resilience, coping styles, anxiety and depression. Hierarchical linear regression was used to assess the contributions of these variables to anxiety and depression.

Results: After adjusting for demographic variables, the following factors were associated with parents' anxiety and depression symptoms: (i) Whether or not the participants had a child with ASD; (ii) resilience; (iii) coping strategies, and; (iv) the impact due to COVID-19. Among these, the psychological stress caused by COVID-19 played the most important role in parental anxiety (β = 0.353) and depression (β = 0.242) symptoms. Parents of children with ASD had lower levels of resilience and positive coping, and used more negative coping strategies than parents of TD children. Among all participants, 8.0 and 24.2% of parents had symptoms of anxiety and depression, respectively. Compared to parents of TD children, more parents of children with ASD exhibited symptoms of anxiety and depression (12.2% vs. 6.6%; 31.0% vs. 21.7%, respectively).

Conclusions: During the COVID-19 pandemic, parents experienced varying levels of anxiety and depression, particularly, parents of children with ASD. More specific attention should be paid to parental mental health and long-term effective intervention programs, that are targeted towards parents of children with ASD, and such programs should be promoted around China in the wake of the COVID-19 crisis.
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http://dx.doi.org/10.1186/s12992-021-00674-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7905970PMC
February 2021

Impacts of Ambient Fine Particulate Matter on Blood Pressure Pattern and Hypertensive Disorders of Pregnancy: Evidence From the Wuhan Cohort Study.

Hypertension 2021 Apr 22;77(4):1133-1140. Epub 2021 Feb 22.

From the Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China (Y.Z., J. Li, J. Liao, C.H., W.X., S.X., Y.L.).

[Figure: see text].
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.120.15608DOI Listing
April 2021