Wei Peng Yong

Wei Peng Yong

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Wei Peng Yong

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DNA epigenetic signature predictive of benefit from neoadjuvant chemotherapy in oesophageal adenocarcinoma: results from the MRC OE02 trial.

Eur J Cancer 2019 Dec 23;123:48-57. Epub 2019 Oct 23.

Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore; Cancer Science Institute of Singapore, National University of Singapore, Singapore; Biomedical Research Council, Agency for Science, Technology and Research, Singapore; SingHealth/Duke-NUS Institute of Precision Medicine, National Heart Centre Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2019.09.016DOI Listing
December 2019

Predictors of survival outcome following radical gastrectomy for gastric cancer.

ANZ J Surg 2019 01 28;89(1-2):84-89. Epub 2019 Jan 28.

Department of Surgery, National University Hospital, Singapore.

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http://doi.wiley.com/10.1111/ans.15011
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http://dx.doi.org/10.1111/ans.15011DOI Listing
January 2019

The Role of Liver-Directed Therapy in Metastatic Colorectal Cancer.

Curr Colorectal Cancer Rep 2018 13;14(5):129-137. Epub 2018 Sep 13.

Department of Haematology-Oncology, National University Cancer Institute, Singapore (NCIS), National University Health System, 1E Kent Ridge Road, Singapore, 119228 Singapore.

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http://link.springer.com/10.1007/s11888-018-0409-6
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http://dx.doi.org/10.1007/s11888-018-0409-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153585PMC
September 2018

Resisting resistance to cancer immunotherapy.

Thorac Cancer 2018 05 7;9(5):507-508. Epub 2018 Mar 7.

Department of Haematology-Oncology, National University Cancer Institute, Singapore.

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http://dx.doi.org/10.1111/1759-7714.12614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928381PMC
May 2018

Prospective International Randomized Phase II Study of Low-Dose Abiraterone With Food Versus Standard Dose Abiraterone In Castration-Resistant Prostate Cancer.

J Clin Oncol 2018 05 28;36(14):1389-1395. Epub 2018 Mar 28.

Russell Z. Szmulewitz, Abiola Ibraheem, Elia Martinez, Mark F. Kozloff, Chadi Nabhan, Theodore Karrison, Walter M. Stadler, and Mark J. Ratain, The University of Chicago, Chicago; Mark F. Kozloff, Ingalls Hospital, Harvey; Paul Fishkin, Illinois Cancer Care, Peoria, IL; Cody J. Peer and William D. Figg, National Cancer Institute, Rockville, MD; Bradley Carthon and R. Donald Harvey, Winship Cancer Institute of Emory University, Atlanta, GA; and Wei Peng Yong and Edmund Chiong, National University Cancer Institute, Singapore, Singapore.

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http://ascopubs.org/doi/10.1200/JCO.2017.76.4381
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http://dx.doi.org/10.1200/JCO.2017.76.4381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941614PMC
May 2018

Pan-HDAC inhibition by panobinostat mediates chemosensitization to carboplatin in non-small cell lung cancer via attenuation of EGFR signaling.

Cancer Lett 2018 03 4;417:152-160. Epub 2018 Jan 4.

Cancer Science Institute of Singapore, National University of Singapore, Singapore; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Haematology-Oncology, National University Cancer Institute, Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2017.12.030DOI Listing
March 2018

A phase I/Ib study of OTSGC-A24 combined peptide vaccine in advanced gastric cancer.

BMC Cancer 2018 03 27;18(1):332. Epub 2018 Mar 27.

Department of Haematology-Oncology, National University Health System, 5 Lower Kent Ridge Road, Main Building Level 2, Singapore, S119074, Singapore.

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http://dx.doi.org/10.1186/s12885-018-4234-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870101PMC
March 2018

Identification of Gastric Cancer Biomarkers Using 1H Nuclear Magnetic Resonance Spectrometry.

PLoS One 2016 9;11(9):e0162222. Epub 2016 Sep 9.

Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0162222PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017672PMC
August 2017

Chemotherapy for advanced gastric cancer.

Cochrane Database Syst Rev 2017 08 29;8:CD004064. Epub 2017 Aug 29.

Department of Oncology, Lausanne University Hospitals and Clinics, Rue du Bugnon 46, Lausanne, Switzerland, 1011.

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http://dx.doi.org/10.1002/14651858.CD004064.pub4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483552PMC
August 2017

Anti-tumor efficacy evaluation of a novel monoclonal antibody targeting neutral amino acid transporter ASCT2 using patient-derived xenograft mouse models of gastric cancer.

Am J Transl Res 2017 15;9(7):3399-3410. Epub 2017 Jul 15.

Singapore Translational Research Laboratory, Kyowa Hakko Kirin (Singapore) Pte. Ltd.11, Biopolis Way, 138667, #05-08 Helios, Singapore.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527254PMC
July 2017

Upregulation of thioredoxin-1 in activated human NK cells confers increased tolerance to oxidative stress.

Cancer Immunol Immunother 2017 May 21;66(5):605-613. Epub 2017 Feb 21.

Department of Surgery, National University of Singapore, 1E Kent Ridge Road, Singapore, Singapore.

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http://dx.doi.org/10.1007/s00262-017-1969-zDOI Listing
May 2017

Intraperitoneal chemotherapy for gastric cancer with peritoneal disease: experience from Singapore and Japan.

Gastric Cancer 2017 Mar 20;20(Suppl 1):122-127. Epub 2016 Oct 20.

Department of Surgery, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.1007/s10120-016-0660-yDOI Listing
March 2017

Conversion Surgery Post-Intraperitoneal Paclitaxel and Systemic Chemotherapy for Gastric Cancer Carcinomatosis Peritonei. Are We Ready?

J Gastrointest Surg 2017 03 15;21(3):425-433. Epub 2016 Dec 15.

Department of Haematology-Oncology, National University Cancer Institute, Singapore, Singapore.

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http://dx.doi.org/10.1007/s11605-016-3336-3DOI Listing
March 2017

ATM Expression Predicts Veliparib and Irinotecan Sensitivity in Gastric Cancer by Mediating P53-Independent Regulation of Cell Cycle and Apoptosis.

Mol Cancer Ther 2016 12 16;15(12):3087-3096. Epub 2016 Sep 16.

Cancer Science Institute of Singapore, Yong loo Lin School of Medicine, National University of Singapore, Singapore.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-1002DOI Listing
December 2016

Knockdown of POLA2 increases gemcitabine resistance in lung cancer cells.

BMC Genomics 2016 12 22;17(Suppl 13):1029. Epub 2016 Dec 22.

National University Cancer Institute Singapore, National University Health System, Singapore, Singapore.

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http://dx.doi.org/10.1186/s12864-016-3322-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260101PMC
December 2016

Accumulation of CD11c+CD163+ Adipose Tissue Macrophages through Upregulation of Intracellular 11β-HSD1 in Human Obesity.

J Immunol 2016 11 3;197(9):3735-3745. Epub 2016 Oct 3.

Center for Translational Medicine, Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599;

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http://dx.doi.org/10.4049/jimmunol.1600895DOI Listing
November 2016

A novel combinatorial strategy using Seliciclib(®) and Belinostat(®) for eradication of non-small cell lung cancer via apoptosis induction and BID activation.

Cancer Lett 2016 10 25;381(1):49-57. Epub 2016 Jul 25.

Cancer Science Institute of Singapore, National University of Singapore, Singapore; Department of Pharmacology, National University of Singapore, Singapore; Department of Hematology & Oncology, National University Health System, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2016.07.023DOI Listing
October 2016

Capecitabine pharmacogenetics: historical milestones and progress toward clinical implementation.

Pharmacogenomics 2016 10 27;17(15):1607-1610. Epub 2016 Sep 27.

Department of Haematology-Oncology, National University Cancer Institute, Singapore 119228.

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http://dx.doi.org/10.2217/pgs-2016-0133DOI Listing
October 2016

Strategies and Advancements in Harnessing the Immune System for Gastric Cancer Immunotherapy.

J Immunol Res 2015 22;2015:308574. Epub 2015 Oct 22.

Cancer Science Institute of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228 ; Department of Haematology-Oncology, National University Hospital, Singapore 119228.

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http://dx.doi.org/10.1155/2015/308574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633567PMC
August 2016

Evolving landscape of tumor molecular profiling for personalized cancer therapy: a comprehensive review.

Expert Opin Drug Metab Toxicol 2016 Aug 13;12(8):911-22. Epub 2016 Jun 13.

a Department of Haematology-Oncology , National University Cancer Institute, National University Health System , Singapore , Singapore.

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http://dx.doi.org/10.1080/17425255.2016.1196187DOI Listing
August 2016

Genetic factors affecting drug disposition in Asian cancer patients.

Expert Opin Drug Metab Toxicol 2015 7;11(12):1879-92. Epub 2015 Nov 7.

a Department of Haematology-Oncology , National University Cancer Institute , Singapore 119228.

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http://dx.doi.org/10.1517/17425255.2015.1108964DOI Listing
July 2016

Melanoma associated antigen (MAGE)-A3 promotes cell proliferation and chemotherapeutic drug resistance in gastric cancer.

Cell Oncol (Dordr) 2016 Apr 11;39(2):175-86. Epub 2016 Feb 11.

Department of Haematology-Oncology, National University Hospital, Level 7, NUHS Tower Block, 1E, Kent Ridge Road, Singapore, 119228, Singapore.

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http://dx.doi.org/10.1007/s13402-015-0261-5DOI Listing
April 2016

Translating gastric cancer genomics into targeted therapies.

Crit Rev Oncol Hematol 2016 Apr 18;100:141-6. Epub 2016 Feb 18.

Cancer Science Institute of Singapore, National University of Singapore, Singapore; Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, Singapore; Cancer Therapeutics and Stratified Oncology, Genomic Institute of Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.critrevonc.2016.02.007DOI Listing
April 2016

Signatures of tumour immunity distinguish Asian and non-Asian gastric adenocarcinomas.

Gut 2015 Nov 10;64(11):1721-31. Epub 2014 Nov 10.

Department of Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Singapore, Singapore Cancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School, Singapore, Singapore Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore Cellular and Molecular Research, National Cancer Centre, Singapore, Singapore.

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http://dx.doi.org/10.1136/gutjnl-2014-308252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4680172PMC
November 2015

GTSE1 expression represses apoptotic signaling and confers cisplatin resistance in gastric cancer cells.

BMC Cancer 2015 Jul 25;15:550. Epub 2015 Jul 25.

Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.1186/s12885-015-1550-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514980PMC
July 2015

An integrative approach identified genes associated with drug response in gastric cancer.

Carcinogenesis 2015 Apr 5;36(4):441-51. Epub 2015 Mar 5.

Centre for Quantitative Medicine, Duke-National University of Singapore Graduate Medical School, Singapore, Singapore; Laboratory of Computational Biology, Cancer and Stem Cell Biology Program, Duke-National University of Singapore Graduate Medical School, Singapore, Singapore, Department of Medical Oncology, National Cancer Centre, Singapore, Singapore, Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.1093/carcin/bgv014DOI Listing
April 2015

CT volumetry for gastric carcinoma: association with TNM stage.

Eur Radiol 2014 Dec 21;24(12):3105-14. Epub 2014 Jul 21.

Diagnostic Radiology, National University Health System (NUHS), Singapore, Singapore.

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http://dx.doi.org/10.1007/s00330-014-3316-5DOI Listing
December 2014

Therapeutic potential of highly cytotoxic natural killer cells for gastric cancer.

Int J Cancer 2014 Sep 28;135(6):1390-8. Epub 2014 Feb 28.

Department of Surgery, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.1002/ijc.28780DOI Listing
September 2014

SPHK1 regulates proliferation and survival responses in triple-negative breast cancer.

Oncotarget 2014 Aug;5(15):5920-33

Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore; National University Cancer Institute, Singapore.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171602PMC
http://dx.doi.org/10.18632/oncotarget.1874DOI Listing
August 2014

Potential therapeutic significance of HER-family in esophageal squamous cell carcinoma.

Ann Thorac Cardiovasc Surg 2012 17;18(6):506-13. Epub 2012 Nov 17.

Department of Surgery, National University of Singapore, Singapore.

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http://dx.doi.org/10.5761/atcs.ra.12.01995DOI Listing
June 2013

UGT1A6 polymorphisms modulated lung cancer risk in a Chinese population.

PLoS One 2012 17;7(8):e42873. Epub 2012 Aug 17.

Department of Haematology-Oncology, National University Cancer Institute of Singapore, Singapore, Singapore.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0042873PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422233PMC
April 2013

Clinical impact of drug-drug interaction between aspirin and prednisolone at a cancer center.

Clin Ther 2012 Dec 28;34(12):2259-67. Epub 2012 Nov 28.

Department of Pharmacy, National University of Singapore, Singapore.

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http://dx.doi.org/10.1016/j.clinthera.2012.11.002DOI Listing
December 2012

Validation of the functional assessment of cancer therapy-gastric module for the Chinese population.

Health Qual Life Outcomes 2012 Nov 30;10:145. Epub 2012 Nov 30.

Saw Swee Hock School of Public Health, National University of Singapore, 16 Medical Drive, Block MD3, Singapore 117597, Singapore.

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http://dx.doi.org/10.1186/1477-7525-10-145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520860PMC
November 2012

Systemic therapies for pancreatic cancer--the role of pharmacogenetics.

Curr Drug Targets 2012 Jun;13(6):811-28

Department of Hematology-Oncology, National University Health System, Singapore.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795429PMC
http://dx.doi.org/10.2174/138945012800564068DOI Listing
June 2012

Tamoxifen-induced eccrine squamous syringometaplasia.

J Cutan Pathol 2012 May 6;39(5):554-7. Epub 2012 Mar 6.

University Medicine Cluster, National University Health System, Singapore.

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http://dx.doi.org/10.1111/j.1600-0560.2011.01860.xDOI Listing
May 2012

Gemcitabine and platinum pathway pharmacogenetics in Asian breast cancer patients.

Cancer Genomics Proteomics 2011 Sep-Oct;8(5):255-9

Department of Hematology-Oncology, National University Cancer Institute of Singapore.

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February 2012

Population pharmacokinetics of modafinil and its acid and sulfone metabolites in Chinese males.

Ther Drug Monit 2011 Dec;33(6):719-29

Bioengineering Laboratory, Defence Medical and Environmental Research Institute, DSO National Laboratories, Singapore.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/FTD.0b013e318237a9e9DOI Listing
December 2011

Recent progress and clinical importance on pharmacogenetics in cancer therapy.

Clin Chem Lab Med 2011 Oct 28;49(10):1621-32. Epub 2011 Sep 28.

Department of Hematology-Oncology, National University Cancer Institute, Singapore.

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http://dx.doi.org/10.1515/CCLM.2011.715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858908PMC
October 2011

Germline genetic testing to predict drug response and toxicity in oncology--reality or fiction?

Ann Acad Med Singapore 2011 Aug;40(8):350-5

Department of Hematology-Oncology, National University Cancer Institute Singapore.

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August 2011

Impact of sample heterogeneity on methylation analysis.

Diagn Mol Pathol 2010 Dec;19(4):243-7

Cancer Science Institute of Singapore, National University of Singapore, Singapore.

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http://dx.doi.org/10.1097/PDM.0b013e3181de4396DOI Listing
December 2010

Clinical pharmacology and pharmacogenetics of gemcitabine.

Drug Metab Rev 2009 ;41(2):77-88

Department of Hematology-Oncology, National University Hospital, Singapore.

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http://dx.doi.org/10.1080/03602530902741828DOI Listing
September 2009

Targeted therapeutics-oriented tumor classification: a paradigm shift.

Per Med 2009 Sep;6(5):465-468

Department of Pathology, National University Health System and National University of Singapore, 5 Lower Kent Ridge Road, Singapore 119074, Republic of Singapore. 2Cancer Science Institute, National University of Singapore, Singapore.

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http://dx.doi.org/10.2217/pme.09.34DOI Listing
September 2009

R(+)XK469 inhibits hydroxylation of S-warfarin by CYP2C9.

Eur J Cancer 2009 Jul 21;45(11):1904-8. Epub 2009 May 21.

Committee on Clinical Pharmacology and Pharmacogenomics, The University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1016/j.ejca.2009.04.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758059PMC
July 2009

Distribution of gemcitabine pathway genotypes in ethnic Asians and their association with outcome in non-small cell lung cancer patients.

Lung Cancer 2009 Jan 5;63(1):121-7. Epub 2008 Jun 5.

Department of Haematology-Oncology, National University of Hospital, 5 Lower Kent Ridge Road, Singapore 119074, Singapore.

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http://dx.doi.org/10.1016/j.lungcan.2008.04.010DOI Listing
January 2009

A phase I study of docetaxel with ketoconazole modulation in patients with advanced cancers.

Cancer Chemother Pharmacol 2008 Jul 2;62(2):243-51. Epub 2007 Oct 2.

Cancer Therapeutics Research Group, Department of Haematology-Oncology, National University Hospital, 5 Lower Kent Ridge Road, Singapore, Singapore, 119074.

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http://dx.doi.org/10.1007/s00280-007-0598-1DOI Listing
July 2008

Pharmacokinetic modulation of oral etoposide by ketoconazole in patients with advanced cancer.

Cancer Chemother Pharmacol 2007 Nov 17;60(6):811-9. Epub 2007 Feb 17.

Committee on Clinical Pharmacology and Pharmacogenomics, University of Chicago, 5841 S Maryland Ave, MC2115, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1007/s00280-007-0428-5DOI Listing
November 2007

Translation of pharmacogenetic knowledge into cancer therapeutics.

Clin Adv Hematol Oncol 2007 Sep;5(9):698-706

Department of Haematology-Oncology, National University Hospital, Singapore 119074.

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September 2007

The role of pharmacogenetics in cancer therapeutics.

Br J Clin Pharmacol 2006 Jul;62(1):35-46

University of Chicago, Committee on Clinical Pharmacology and Pharmacogenomics, Department of Medicine and Cancer Research Center, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1111/j.1365-2125.2006.02591.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885075PMC
July 2006

Ketoconazole renders poor CYP3A phenotype status with midazolam as probe drug.

Ther Drug Monit 2006 Apr;28(2):255-61

Department of Hematology-Oncology, National University Hospital, Singapore.

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http://dx.doi.org/10.1097/01.ftd.0000194497.55269.d9DOI Listing
April 2006

Acceptance, motivators, and barriers in attending breast cancer genetic counseling in Asians.

Cancer Detect Prev 2005 23;29(5):412-8. Epub 2005 Sep 23.

Department of Haematology-Oncology, National University Hospital, 5, Lower Kent Ridge Road, Singapore 119074, Singapore.

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http://dx.doi.org/10.1016/j.cdp.2005.06.009DOI Listing
December 2005

Effects of ketoconazole on glucuronidation by UDP-glucuronosyltransferase enzymes.

Clin Cancer Res 2005 Sep;11(18):6699-704

Committee on Clinical Pharmacology and Pharmacogenomics, The University of Chicago, IL 60637, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-05-0703DOI Listing
September 2005