Publications by authors named "Wei Lv"

355 Publications

Cobalt-Doping of Molybdenum Disulfide for Enhanced Catalytic Polysulfide Conversion in Lithium-Sulfur Batteries.

ACS Nano 2021 Apr 9. Epub 2021 Apr 9.

Shenzhen Geim Graphene Center, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China.

Metal sulfides, such as MoS, are widely investigated in lithium-sulfur (Li-S) batteries to suppress the shuttling of lithium polysulfides (LiPSs) due to their chemical adsorption ability and catalytic activity. However, their relatively low conductivity and activity limit the LiPS conversion kinetics. Herein, the Co-doped MoS is proposed to accelerate the catalytic conversion of LiPS as the Co doping can promote the transition from semiconducting 2H phase to metallic 1T phase and introduce the sulfur vacancies in MoS. A one-step hydrothermal process is used to prepare such a Co-doped MoS with more 1T phase and rich sulfur vacancies, which enhances the electron transfer and catalytic activity, thus effectively improving the LiPS adsorption and conversion kinetics. The cathode using the three-dimensional graphene monolith loaded with Co-doped MoS catalyst as the sulfur host shows a high rate capability and long cycling stability. A high capacity of 941 mAh g at 2 C and a low capacity fading of 0.029% per cycle at 1 C over 1000 cycles are achieved, suggesting the effectively suppressed LiPS shuttling and improved sulfur utilization. Good cyclic stability is also maintained under a high sulfur loading indicating the doping is an effective way to optimize the metal sulfide catalysts in Li-S batteries.
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http://dx.doi.org/10.1021/acsnano.1c00896DOI Listing
April 2021

[Clinical Recommendations for Perioperative Immunotherapy-induced Adverse Events in Patients with Non-small Cell Lung Cancer].

Zhongguo Fei Ai Za Zhi 2021 Mar;24(3):141-160

Department of Thoracic Surgery, Peking University Cancer Hospital, Beijing 100142, China.

Background: Perioperative treatment has become an increasingly important aspect of the management of patients with non-small cell lung cancer (NSCLC). Small-scale clinical studies performed in recent years have shown improvements in the major pathological remission rate after neoadjuvant therapy, suggesting that it will soon become an important part of NSCLC treatment. Nevertheless, neoadjuvant immunotherapy may be accompanied by serious adverse reactions that lead to delay or cancelation of surgery, additional illness, and even death, and have therefore attracted much attention. The purpose of the clinical recommendations is to form a diagnosis and treatment plan suitable for the current domestic medical situation for the immune-related adverse event (irAE).

Methods: This recommendation is composed of experts in thoracic surgery, oncologists, thoracic medicine and irAE related departments (gastroenterology, respirology, cardiology, infectious medicine, hematology, endocrinology, rheumatology, neurology, dermatology, emergency section) to jointly complete the formulation. Experts make full reference to the irAE guidelines, large-scale clinical research data published by thoracic surgery, and the clinical experience of domestic doctors and publicly published cases, and repeated discussions in multiple disciplines to form this recommendation for perioperative irAE.

Results: This clinical recommendation covers the whole process of prevention, evaluation, examination, treatment and monitoring related to irAE, so as to guide the clinical work comprehensively and effectively.

Conclusions: Perioperative irAE management is an important part of immune perioperative treatment of lung cancer. With the continuous development of immune perioperative treatment, more research is needed in the future to optimize the diagnosis and treatment of perioperative irAE.
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http://dx.doi.org/10.3779/j.issn.1009-3419.2021.101.06DOI Listing
March 2021

Clinical recommendations for perioperative immunotherapy-induced adverse events in patients with non-small cell lung cancer.

Thorac Cancer 2021 Mar 30. Epub 2021 Mar 30.

Peking University Cancer Hospital, Beijing, China.

Perioperative adjuvant treatment has become an increasingly important aspect of the management of patients with non-small cell lung cancer (NSCLC). In particular, the success of immune checkpoint inhibitors, such as antibodies against PD-1 and PD-L1, in patients with lung cancer has increased our expectations for the success of these therapeutics as neoadjuvant immunotherapy. Neoadjuvant therapy is widely used in patients with resectable stage IIIA NSCLC and can reduce primary tumor and lymph node stage, improve the complete resection rate, and eliminate microsatellite foci; however, complete pathological response is rare. Moreover, because the clinical benefit of neoadjuvant therapy is not obvious and may complicate surgery, it has not yet entered the mainstream of clinical treatment. Small-scale clinical studies performed in recent years have shown improvements in the major pathological remission rate after neoadjuvant therapy, suggesting that it will soon become an important part of NSCLC treatment. Nevertheless, neoadjuvant immunotherapy may be accompanied by serious adverse reactions that lead to delay or cancellation of surgery, additional illness, and even death, and have therefore attracted much attention. In this article, we draw on several sources of information, including (i) guidelines on adverse reactions related to immune checkpoint inhibitors, (ii) published data from large-scale clinical studies in thoracic surgery, and (iii) practical experience and published cases, to provide clinical recommendations on adverse events in NSCLC patients induced by perioperative immunotherapy.
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http://dx.doi.org/10.1111/1759-7714.13942DOI Listing
March 2021

Biological Mediator-Propelled Nanosweeper for Nonpharmaceutical Thrombus Therapy.

ACS Nano 2021 Mar 16. Epub 2021 Mar 16.

Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China.

Traditional thrombolytic drugs offer limited outcomes due to short circulation half-life and low utilization. Herein, we have designed and constructed a biological mediator-propelled nanosweeper for highly efficient nonpharmaceutical thrombolysis and prevention of thrombus recurrence. Under the near-infrared light irradiation, the nanosweepers were activated to trigger nitric oxide (NO) release, which propelled the nanosweepers to penetrate deeply into the thrombus and resulted in enhanced site-pecific mechanical and photothermal thrombolysis. The experimental evidence confirmed that the ingenious nanosweeper displayed excellent site-specific thrombolytic efficacy even when compared with the clinical thrombolytic drug. In the meantime, as a biological mediator, the release of NO could effectively prevent thrombus recurrence . Overall, we anticipated that the nanosweeper would provide a promising strategy for the treatment of thrombi.
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http://dx.doi.org/10.1021/acsnano.0c09939DOI Listing
March 2021

HIF-1/AKT Signaling-Activated PFKFB2 Alleviates Cardiac Dysfunction and Cardiomyocyte Apoptosis in Response to Hypoxia.

Int Heart J 2021 Mar 6;62(2):350-358. Epub 2021 Mar 6.

Department of Cardiology, Central Hospital Affiliated to Shandong First Medical University.

Myocardial infarction (MI) is the most prevalent disease with severe mortality, and hypoxia-induced cardiac injury and cardiomyocyte apoptosis are the significant and harmful consequences of this disease. The cross talk between hypoxia signaling and glycolysis energy flux plays a critical role in modulating MI-related heart disorder. However, the underlying mechanism remains unclear. Here, we aimed to explore the effect of a key glycolytic enzyme of 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2 (PFKFB2) on cardiac dysfunction and apoptosis in response to hypoxia. Our data demonstrated that the mRNA and protein expression of PFKFB2 were significantly elevated in the MI mice. The MI treatment promoted the activation of PFKFB2 in vivo, as presented by the remarkably increased phosphorylation levels of PFKFB2. PFKFB2 depletion enhanced MI-induced cardiac dysfunction and cardiomyocyte apoptosis in the MI mouse model. Moreover, hypoxia treatment dramatically upregulated the expression and activation of PFKFB2 in a time-dependent manner in cardiomyocytes. Hypoxia-stimulated PFKFB2 relieved hypoxia-induced cardiomyocyte apoptosis in vitro. PFKFB2 activated the fructose-2, 6-bisphosphate (Fru-2, 6-p2) /PFK/anaerobic adenosine triphosphate (ATP) glycolysis energy flux in response to hypoxia in cardiomyocytes. Mechanically, hypoxia-activated PFKFB2 by stimulating the hypoxia-inducible factor 1 (HIF-1) /ATK signaling. Thus, we conclude that HIF-1/AKT axis-activated PFKFB2 alleviates cardiac dysfunction and cardiomyocyte apoptosis in response to hypoxia. Our finding presents a new insight into the mechanism by which HIF-1/AKT/PFKFB2 signaling modulates MI-related heart disorder under the hypoxia condition, providing potential therapeutic targets and strategy for hypoxia-related myocardial injury.
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http://dx.doi.org/10.1536/ihj.20-315DOI Listing
March 2021

Morphological speculation of the MHPD and related clinical projections.

Surg Radiol Anat 2021 Mar 4. Epub 2021 Mar 4.

Department of Hepatobiliary Surgery, General Rocket Hospital of Chinese People's Liberation Army, Beijing, People's Republic of China.

Objective: The concept of mesopancreas has been brought into focus nowadays. Studies on membrane morphology of pancreas are clinically significant in determining an ideal surgical route for a "holy plane". In this paper, we aimed to observe the structure of the peripancreatic membranes and its interactions with adjacent tissues; tentatively put forward the proposition of mesohepatopancreaticoduodenum (MHPD) and explore in depth in surgical local resection.

Methods: 33 cadavers were examined in the experiment, including 30 for gross anatomy and 3 for histological observation after transection. The histological characteristics of the membrane covering the pancreas were proved by Masson and Bielschowsky silver staining and further explored in clinical application and testified in a surgical scenario. All above were carried out through traditional procedures.

Results: The anterior surface membrane of the pancreas was intact and the posterior portion expanding to the pancreaticoduodenum enclosed the surface of the duodenum and the pancreatic head, which could be easily isolated from the posterior abdominal wall. The posterior surface membrane around the body and tail wrapped the pancreatic parenchyma, which created a soft-tissue window for the posterior abdominal wall. Then, dense connective tissue adhesions were detected between the celiac artery and the superior mesenteric artery.

Conclusions: The embryonic origin of the mesopancreas and the surgical procedures were reviewed and inspected based on the proposition of MHPD and above results. We hope that this study could stir up our interest in the advancement of imaging diagnoses and minimally invasive surgical treatment of pancreas.
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http://dx.doi.org/10.1007/s00276-021-02725-6DOI Listing
March 2021

A bibliometric analysis of occupational low back pain studies from 2000 to 2020.

Arch Environ Occup Health 2021 Mar 3:1-10. Epub 2021 Mar 3.

School of Industrial Engineering, Purdue University, West Lafayette, Indiana, USA.

This study aimed to explore the evolution tracks of occupational low back pain (OLBP) studies during 2000 ∼ 2020 through strict and systematic bibliometric analysis. The analysis began with data retrieval in Web of Science using defined search terms associated with OLBP. Bibliometric tools, including BibExcel and CiteSpace, were employed to conduct performance analysis and co-citation network analysis. Totally, 4,127 documents were identified from 2000 to 2020. The United States contributed the most publications. The leading journals mainly focused on medicine and ergonomics. The co-citation analysis illuminated the development of OLBP studies and the top three published keywords were musculoskeletal disorder, risk factors, and fear avoidance. This paper can help researchers have a broader and deeper understanding of OLBP studies, provide a general insight into aggregate performance in the OLBP field, and find further research directions.
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http://dx.doi.org/10.1080/19338244.2021.1893634DOI Listing
March 2021

Photocatalytic degradation of ranitidine and reduction of nitrosamine dimethylamine formation potential over MXene-TiC/MoS under visible light irradiation.

J Hazard Mater 2021 Feb 13;413:125424. Epub 2021 Feb 13.

Institute of Environmental Engineering & Nano-Technology, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, Guangdong, China; School of Environment, Tsinghua University, Beijing 100084, China. Electronic address:

Photocatalysis is an effective method to degrade ranitidine (RAN), which is a typical precursor of nitrosamine dimethylamine (NDMA), an extremely potent human carcinogen. Herein, MXene-TiC/MoS composites were prepared by a hydrothermal treatment aiming to use them for the photocatalytic degradation of RAN and the reduction of NDMA formation potential (NDMA-FP) under visible light irradiation for the first time. The analysis of the morphology, chemical composition and structure of these composites as well as the results of electrochemical experiments showed that a heterojunction was formed between MoS and TiC, which facilitated the separation of electron-hole pairs and charge transfer, and thereby the photocatalytic performance. The MXene-TiC/MoS composite (MT-4) exhibited the best photocatalytic performance in 60 min, with the highest RAN degradation and mineralization efficiencies of 88.4% and 73.58%, and the lowest NDMA-FP of 2.01%. Active species, including •O radicals, h and •OH radicals, all contributed to the degradation of RAN, among which •OH radicals were the main active species involved in the photocatalytic activity. The mechanism of the photocatalytic degradation of RAN over MXene-TiC/MoS photocatalyst under visible light irradiation was proposed. This work opens up a new perspective on the applications of MXene-based materials for photocatalytic degradation of challenging pollutants.
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http://dx.doi.org/10.1016/j.jhazmat.2021.125424DOI Listing
February 2021

Functional Non-coding RNA During Embryonic Myogenesis and Postnatal Muscle Development and Disease.

Front Cell Dev Biol 2021 28;9:628339. Epub 2021 Jan 28.

Key Laboratory of Swine Genetics and Breeding of the Ministry of Agriculture and Rural Affairs, Huazhong Agricultural University, Wuhan, China.

Skeletal muscle is a highly heterogeneous tissue that plays a crucial role in mammalian metabolism and motion maintenance. Myogenesis is a complex biological process that includes embryonic and postnatal development, which is regulated by specific signaling pathways and transcription factors. Various non-coding RNAs (ncRNAs) account for the majority of total RNA in cells and have an important regulatory role in myogenesis. In this review, we introduced the research progress in miRNAs, circRNAs, and lncRNAs related to embryonic and postnatal muscle development. We mainly focused on ncRNAs that regulate myoblast proliferation, differentiation, and postnatal muscle development through multiple mechanisms. Finally, challenges and future perspectives related to the identification and verification of functional ncRNAs are discussed. The identification and elucidation of ncRNAs related to myogenesis will enrich the myogenic regulatory network, and the effective application of ncRNAs will enhance the function of skeletal muscle.
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http://dx.doi.org/10.3389/fcell.2021.628339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876409PMC
January 2021

Incomplete ablation of colon cancer cells may induce activation of dormant cells: Evidence from bioinformatics analysis.

J Cancer Res Ther 2020 ;16(7):1596-1602

Department of Oncology, Jinan Central Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Purpose: It is not yet verified whether incomplete radiofrequency ablation (iRFA) induces tumor progression and hypoxia related to tumor dormancy. This study showed the relationship between iRFA and tumor dormancy.

Materials And Methods: To identify the candidate genes in the control and iRFA-treated colon cancer cells, microarray datasets GSE138224 were downloaded from Gene Expression Omnibus database. Using NetworkAnalyst, the differentially expressed genes (DEGs) were identified, function enrichment analyses were performed, and the protein-protein interaction (PPI) network and key PPI network were constructed.

Results: A total of 656 DEGs were identified, comprising 637 downregulated and 19 upregulated genes. The enriched functions and pathways of the upregulated DEGs include an immune effector process, regulation of tyrosine phosphorylation of signal transducer and activator of transcription (STAT) protein, tyrosine phosphorylation of STAT protein, JAK-STAT cascade, and regulating JAK-STAT cascade, and CCL5 gene participated in regulating the JAK-STAT signaling pathway. The downregulated DEGs were mainly enriched in extracellular matrix-receptor interaction, PI3K-Akt signaling, Wnt signaling, transforming growth factor-beta signaling, and mitogen-activated protein kinase signaling pathways. There are three key PPI networks of DEGs (degree ≥10 and hub genes >3). The dormancy-related genes Bmp4 and Ccl5 were regarded as hub genes in the PPI network with Bmp4 as a downregulated gene and CCL5 as an upregulated gene.

Conclusion: The identified DEGs and function enrichment analyses in this study aid the understanding of molecular mechanisms underlying the relationship between iRFA and tumor dormancy.
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http://dx.doi.org/10.4103/jcrt.JCRT_729_20DOI Listing
January 2020

Id3 and Bcl6 Promote the Development of Long-Term Immune Memory Induced by Tuberculosis Subunit Vaccine.

Vaccines (Basel) 2021 Feb 5;9(2). Epub 2021 Feb 5.

Gansu Provincial Key Laboratory of Evidence Based Medicine and Clinical Translation & Lanzhou Center for Tuberculosis Research, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China.

Long-lived memory cell formation and maintenance are usually regulated by cytokines and transcriptional factors. Adjuvant effects of IL-7 have been studied in the vaccines of influenza and other pathogens. However, few studies investigated the adjuvant effects of cytokines and transcriptional factors in prolonging the immune memory induced by a tuberculosis (TB) subunit vaccine. To address this research gap, mice were treated with the () subunit vaccine Mtb10.4-HspX (MH) plus ESAT6-Ag85B-MPT64-Mtb8.4-Rv2626c (LT70), together with adeno-associated virus-mediated IL-7 or lentivirus-mediated transcriptional factor Id3, Bcl6, Bach2, and Blimp1 at 0, 2, and 4 weeks, respectively. Immune responses induced by the vaccine were examined at 25 weeks after last immunization. The results showed that adeno-associated virus-mediated IL-7 allowed the TB subunit vaccine to induce the formation of long-lived memory T cells. Meanwhile, IL-7 increased the expression of , , and -the three key transcription factors for the generation of long-lived memory T cells. The adjuvant effects of transcriptional factors, together with TB fusion protein MH/LT70 vaccination, showed that both Bcl6 and Id3 increased the production of antigen-specific antibodies and long-lived memory T cells, characterized by high proliferative potential of antigen-specific CD4 and CD8 T cells, and IFN-γ secretion in CD4 and CD8 T cells, respectively, after re-exposure to the same antigen. Overall, our study suggests that IL-7 and transcriptional factors Id3 and Bcl6 help the TB subunit vaccine to induce long-term immune memory, which contributes to providing immune protection against infection.
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http://dx.doi.org/10.3390/vaccines9020126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914852PMC
February 2021

Molecular characterization and serodiagnostic potential of Echinococcus granulosus hexokinase.

Parasit Vectors 2021 Feb 8;14(1):105. Epub 2021 Feb 8.

Institute of Pathogenic Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China.

Background: Cystic echinococcosis (CE), caused by the larval stage of Echinococcus granulosus (sensu stricto), is a life-threatening but neglected zoonosis. Glycolytic enzymes are crucial molecules for the survival and development of E. granulosus. The aim of this study was to investigate the molecular characterization, immunogenicity, tissue distribution and serodiagnostic potential of E. granulosus hexokinase (EgHK), the first key enzyme in the glycolytic pathway.

Methods: EgHK was cloned and expressed in Escherichia coli. Specific serum antibodies were evaluated in mice immunized with recombinant EgHK (rEgHK). The location of EgHK in the larval stage of E. granulosus was determined using fluorescence immunohistochemistry, and the potential of rEgHK as a diagnostic antigen was investigated in patients with CE using indirect enzyme-linked immunosorbent assay (ELISA).

Results: Recombinant EgHK could be identified in the sera of patients with CE and in mouse anti-rEgHK sera. High titers of specific immunoglobulin G were induced in mice after immunization with rEgHK. EgHK was mainly located in the tegument, suckers and hooklets of protoscoleces and in the germinal layer and laminated layer of the cyst wall. The sensitivity and specificity of the rEgHK-ELISA reached 91.3% (42/46) and 87.8% (43/49), respectively.

Conclusions: We have characterized the sequence, structure and location of EgHK and investigated the immunoreactivity, immunogenicity and serodiagnostic potential of rEgHK. Our results suggest that EgHK may be a promising candidate for the development of vaccines against E. granulosus and an effective antigen for the diagnosis of human CE.
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http://dx.doi.org/10.1186/s13071-021-04606-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7869421PMC
February 2021

Secondary prevention medication persistence and prognosis of acute ischaemic stroke or transient ischaemic attack.

Stroke Vasc Neurol 2021 Feb 1. Epub 2021 Feb 1.

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

Introduction: The risk of disability and mortality is high among recurrent stroke, which highlights the importance of secondary prevention measures. We aim to evaluate medication persistence for secondary prevention and the prognosis of acute ischaemic stroke or transient ischaemic attack (TIA) in China.

Methods: Patients with acute ischaemic stroke or TIA from the China National Stroke Registry II were divided into 3 groups based on the percentage of persistence in secondary prevention medication classes from discharge to 3 months after onset (level I: persistence=0%, level II: 0%
Results: 18 344 patients with acute ischaemic stroke or TIA were included, 315 (1.7%) of whom experienced recurrent strokes. Compared with level I, the adjusted HR of recurrent stroke for level II was 0.41 (95% CI 0.31 to 0.54) and level III 0.37 (0.28 to 0.48); composite events for level II 0.41 (0.32 to 0.53) and level III 0.38 (0.30 to 0.49); all-cause death for level II 0.28 (0.23 to 0.35) and level III 0.20 (0.16-0.24). Compared with level I, the adjusted OR of disability for level II was 0.89 (0.77 to 1.03) and level III 0.82 (0.72 to 0.93).

Conclusions: Persistence in secondary prevention medications, especially in all classes of medications prescribed by the physician, was associated with lower hazard of recurrent stroke, composite events, all-cause death and lower odds of disability in patients with acute ischaemic stroke or TIA.
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http://dx.doi.org/10.1136/svn-2020-000471DOI Listing
February 2021

Associations of Prenatal Exposure to Triclosan and Maternal Thyroid Hormone Levels: A Systematic Review and Meta-Analysis.

Front Endocrinol (Lausanne) 2020 13;11:607055. Epub 2021 Jan 13.

Department of Obstetrics, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China.

Objective: To quantitatively evaluate associations between exposure to triclosan during pregnancy and maternal thyroid hormone levels.

Method: The databases of PubMed, Embase, Web of Science and Cochrane Library were systematically searched to identify relevant studies on the relationship between prenatal exposure to triclosan and maternal levels of serum thyroid hormone published before October 22, 2019. Stata 12.0 was used to examine the heterogeneity among the eligible studies.

Results: Seven studies involving a total of 4,136 participants were included. Overall, descriptive analysis provided no indication that exposure to TCS during pregnancy was related to either maternal FT4 levels (ES = 0.01, 95% CI: -0.03 to 0.05, = 0.00) or TSH levels (ES = -0.03, 95% CI: -0.13 to 0.07, = 0.412). Although the results were statistically insignificant, with the increase of urine TCS concentration, maternal FT4 levels exhibited a tendency to increase while TSH levels had a tendency to decrease during pregnancy.

Conclusion: The results indicated that exposure to triclosan during pregnancy has no significant influence on maternal levels of thyroid hormone. On account of the inconsistency of existing research designs and study locations, further studies and replication are necessary to confirm these findings.
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http://dx.doi.org/10.3389/fendo.2020.607055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7839534PMC
January 2021

Characterization of volatile compounds in differently coloured Chenopodium quinoa seeds before and after cooking by headspace-gas chromatography-ion mobility spectrometry.

Food Chem 2021 Jun 18;348:129086. Epub 2021 Jan 18.

Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, China. Electronic address:

Aroma is an important feature of quinoa that influences consumer preferences. Differently coloured quinoa seeds exhibit diverse nutritional characteristics; however, their aromatic profile differences are poorly investigated. The volatile components of 11 quinoa samples were characterized by headspace-gas chromatography-ion mobility spectrometry (HS-GC-IMS). A total of 120 peaks were detected, with 61 compounds identified. White quinoa liberated a high concentration of volatiles with grass (n-hexanol) and green ((E)-2-octenal, (E)-2-heptenal, etc.) aromas before and after cooking, respectively. Raw flaxen samples uniquely released a caramel compound (cyclotene) and exhibited several sweet and caramel volatiles (decanal, 5-methyl-furfural, and 2-furfural) after cooking. Additionally, cooked black quinoa exerted more fruity substances (methyl hexanoate and phenylacetaldehyde). Orthogonal partial least square discriminant analysis clearly distinguished the samples before and after cooking and differentiated the seeds into different colours. The results confirm the potential of HS-GC-IMS to evaluate volatiles in quinoa and are meaningful for quinoa consumption.
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http://dx.doi.org/10.1016/j.foodchem.2021.129086DOI Listing
June 2021

Multiple 'omics'-analysis reveals the role of prostaglandin E2 in Hirschsprung's disease.

Free Radic Biol Med 2021 Feb 16;164:390-398. Epub 2021 Jan 16.

State Key Laboratory of Reproductive Medicine, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 211166, China. Electronic address:

The etiology and pathogenesis of Hirschsprung's disease (HSCR) remain largely unknown. We examined colon tissues from three independent populations with a combined analysis of metabolomics, transcriptomics and proteomics to understand HSCR pathogenesis, according to which mouse model was used to examine prostaglandin E2 (PGE2) induced clinical presentation of HSCR. SH-SY5Y and SK-N-BE(2) cell lines were studied for PGE2 inhibited cell migration through EP2. Our integrated multiple 'omics'-analysis suggests that the levels of PGE2, the expression of the gene encoding PGE2 receptor (EP2), and PGE2 synthesis enzyme genes (PTGS1 and PTGES) increased in HSCR colon tissues, together with a decreased synthesis of PGE2-related byproducts. In vivo, the pregnant mice treated with PGE2 gave birth to offspring with the decrease of ganglion cells in their colon and gut function. In in vitro study, when EP2 was blocked, the PGE2-inhibited cell migration was recovered. Our study identified a novel pathway highlighting the link between expression of PTGS1 and PTGES, levels of PGE2, expression of PTGER2, and neural crest cell migration in HSCR, providing a novel strategy for future diagnosis and prevention of HSCR.
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http://dx.doi.org/10.1016/j.freeradbiomed.2020.12.456DOI Listing
February 2021

Relationship between CYP17A1-Mediated DNA Demethylation and Proliferation, Invasion and Metastasis of Glioma Cells.

Crit Rev Eukaryot Gene Expr 2020 ;30(6):475-482

Department of Neurosurgery, Wuhan Asia General Hospital, Wuhan, Hubei, China.

Objective: We investigated the relationship between CYP17A1-mediated DNA demethylation and proliferation, invasion, and metastasis of glioma cells.

Methods: The expression of CYP17A1 mRNA and protein in cells was determined by PCR and Western blot assays. The methylation status of CYP17A1 was detected by the MSP method. Cell proliferation and apoptosis were detected by MTT assays and flow cytometry. Cell invasion and metastasis were measured by cell invasion assays.

Results: The relative expression of CYP17A1 mRNA was significantly different among the model, experimental, and normal groups (P < 0.05). Relative expression was significantly decreased in the experimental group relative to the cancer model group (P < 0.05). Immunohistochemistry showed that expression of CYP17A1 in glioma was significantly higher than in the normal group (P < 0.05). Methylation analysis showed that CYP17A1 was not detected in normal cells, and the methylation rate in the model group was 89.03%. The methylation rate in the experimental group was 43.93%, which was significantly lower than that of the model group (P < 0.05). MTT assays showed that DHEA plus temozolomide (TMZ) pretreatment significantly inhibited cell proliferation rate (P < 0.05). Flow cytometry showed that DHEA plus TMZ pretreatment significantly increased apoptosis rate (P < 0.05). In colony formation assays, the number of CYP17A1 colonies in the model and experimental groups was 78.09% ± 10.21% and 38.97% ± 11.32%, respectively. The number of colonies in the experimental group was significantly lower than in the model group (P < 0.05). The migration ability of the model group was significantly higher than that of the control group (P < 0.05). The invasion rate of the experimental group was significantly lower than that of the model group (P < 0.05).

Conclusion: CYP17A1-induced DNA demethylation can inhibit proliferation, invasion, and metastasis of glioma cells.
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http://dx.doi.org/10.1615/CritRevEukaryotGeneExpr.2020035994DOI Listing
January 2020

pH-Dependent Morphology Control of Cellulose Nanofiber/Graphene Oxide Cryogels.

Small 2021 Jan 22;17(3):e2005564. Epub 2020 Dec 22.

Nanoyang Group, State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin University, Tianjin, 300072, China.

The precise control of the ice crystal growth during a freezing process is of essential importance for achieving porous cryogels with desired architectures. The present work reports a systematic study on the achievement of multi-structural cryogels from a binary dispersion containing 50 wt% 2,2,6,6-tetramethylpiperidin-1-oxyl, radical-mediated oxidized cellulose nanofibers (TOCNs), and 50 wt% graphene oxide (GO) via the unidirectional freeze-drying (UDF) approach. It is found that the increase in the sol's pH imparts better dispersion of the two components through increased electrostatic repulsion, while also causing progressively weaker gel networks leading to micro-lamella cryogels from the UDF process. At the pH of 5.2, an optimum between TOCN and GO self-aggregation and dispersion is achieved, leading to the strongest TOCN-GO interactions and their templating into the regular micro-honeycomb structures. A two-faceted mechanism for explaining the cryogel formation is proposed and it is shown that the interplay of the maximized TOCN-GO interactions and the high affinity of the dispersoid complexes for the ice crystals are necessary for obtaining a micro-honeycomb morphology along the freezing direction. Further, by linking the microstructure and rheology of the corresponding precursor sols, a diagram for predicting the microstructure of TOCN-GO cryogels obtained through the UDF process is proposed.
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http://dx.doi.org/10.1002/smll.202005564DOI Listing
January 2021

CO combining power and outcomes in patients with acute ischaemic stroke or transient ischaemic attack.

Stroke Vasc Neurol 2020 Dec 9. Epub 2020 Dec 9.

China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

Background And Purpose: The clinical significance of carbon dioxide combining power (COCP) in ischaemic cerebrovascular disease is not well established, and the role of COCP in the prognosis of acute ischaemic stroke (AIS) or transient ischaemic attack (TIA) has not been reported. The objective of the study was to investigate the associations between COCP and clinical outcomes in patients with AIS or TIA.

Methods: Data were derived from the China National Stroke Registry III. Patients were classified into five groups by quintiles of COCP levels and three groups according to the normal range of COCP (23-29 mmol/L). Multivariable Cox and logistic regressions were adopted to explore the associations of COCP levels with all-cause death and poor functional outcomes (modified Rankin Scale (mRS) 3-6/2-6) at 3 months and 1 year.

Results: Among 9531 patients included in the study, the median (IQR) COCP was 24.9 (23.0-27.0) mmol/L. After adjustment for potential confounders, patients in the first COCP quintile (21.1-23.3 mmol/L) had higher risk of all-cause death and poor functional outcomes (mRS score of 3-6/2-6) (HR or OR with 95% CI 2.37 (1.32 to 4.25), 1.49 (1.20 to 1.83) and 1.21 (1.03 to 1.42), respectively) compared with those in the fourth quintile. Similar results were found for outcomes at 1 year. Furthermore, all associations were also significant when COCP was <23 mmol/L compared with COCP of 23-29 mmol/L.

Conclusions: Decreased COCP was associated with high risk of all-cause death and poor functional outcomes in patients with AIS or TIA.
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http://dx.doi.org/10.1136/svn-2020-000476DOI Listing
December 2020

Clinical Characteristics and Surgical Outcomes of Sinonasal Lesions Associated With Tumor-Induced Osteomalacia.

Otolaryngol Head Neck Surg 2020 Dec 8:194599820975432. Epub 2020 Dec 8.

Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Objective: To investigate the clinical characteristics and surgical outcomes of sinonasal tumors associated with tumor-induced osteomalacia (TIO).

Study Design: Retrospective case series.

Setting: Single tertiary center.

Methods: We studied the clinical characteristics and surgical outcomes of 43 patients (22 male, 21 female) who had lesions in the nasal cavity and paranasal sinus associated with TIO and underwent surgery between August 2006 and November 2019.

Results: The mean ± SD duration between the onset of symptoms and surgery was 3.9 ± 2.6 years. The most common tumor site was the ethmoid sinus (76.7%), and the skull base was involved in 12 cases. Phosphaturic mesenchymal tumors were diagnosed in 41 patients, among whom there was 1 multifocal case. Another 2 cases involved odontogenic fibroma and hemangiofibroma, respectively. Serum phosphorus normalized in 39 cases within 4.4 ± 2.3 days, and serum fibroblastic growth factor 23 normalized within 1 day; clinical symptoms, however, gradually improved within several months after the first operation. There was no significant difference in the recovery rate between endoscopic and open surgery ( = 0.639). Two patients with recurrent cases and 2 with nonremission cases recovered after a sinonasal reoperation. The patient with a multifocal case recovered after the resection of the tumors in the ethmoid sinus and mandible. The overall recovery rate was 97.7%.

Conclusion: Most sinonasal tumors associated with TIO are located in the ethmoid sinus, and the skull base is involved in some cases. Complete excision of the tumor leads to recovery, and endoscopic surgery could achieve recovery rates similar to those of open surgery.
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http://dx.doi.org/10.1177/0194599820975432DOI Listing
December 2020

Hydrophobic Modification on the Surface of SiO Nanoparticle: Wettability Control.

Langmuir 2020 Dec 3;36(49):14924-14932. Epub 2020 Dec 3.

College of Chemistry & Chemical Engineering, Xi'an Shiyou University, Xi'an 710065, China.

Good control of the morphology, particle size, and wettability of silica nanoparticles is of increasing importance to their use in a variety of fields. Here, we propose a strategy to tune the surface wettability of nanosilica by changing the dosage of a chemical modifier. A series of measurements, including scanning electron microscopy (SEM), laser scatting technique, Fourier transform infrared (FTIR) spectroscopy, thermogravimetry, and surface hydroxyl number and water contact angle measurement, were conducted to verify the surface chemistry and wettability of these nanoparticles. Through controlled chemical modification, the contact angle of the treated nanoparticles increases from 34.7 to 155° with increasing amount of dichlorodimethylsilane (DCDMS) within a molar ratio (MR) between DCDMS and nanoparticles of 5.17. The number of hydroxyl groups covered on the particle surface decreases gradually from 1.79 to 0.47, and the surface grafting rate could reach 73.7%. As the addition of dichlorodimethylsilane equals MR 5.17, the contact angle reaches the maximum value of 155°, which displays excellent superhydrophobicity. After surpassing the point of MR 5.17, the contact angle does not increase but starts to decrease, ultimately remaining stable at 135°. It can be concluded that the surface wettability of nano-SiO particles can be precisely modulated by varying the amounts of the modifier. Furthermore, the modulating mechanism of the process occurring on the surface of SiO particles has been investigated at the molecular level.
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http://dx.doi.org/10.1021/acs.langmuir.0c02118DOI Listing
December 2020

SlWHY2 interacts with SlRECA2 to maintain mitochondrial function under drought stress in tomato.

Plant Sci 2020 Dec 12;301:110674. Epub 2020 Sep 12.

State Key Laboratory of Crop Biology, College of Life Sciences, Shandong Agricultural University, Tai' an, Shandong 271018, China. Electronic address:

Drought stress in plants leads to inhibition of photosynthesis and respiration, accumulation of reactive oxygen species (ROS), and reprogramming of gene expression. Here, we established that the tomato (Solanum lycopersicum) WHIRLY2 (SlWHY2) gene, which encodes a mitochondrial single-stranded DNA-binding protein, was significantly induced by drought stress. Under drought conditions, SlWHY2 RNAi plants showed more wilting and lower fresh weight, chlorophyll content, quantum yield of photosystem I (PSI; YI), and maximal photochemical efficiency of PSII (Fv/Fm) than the wild type (WT). Drought treatment also caused the SlWHY2 RNAi lines to accumulate more ROS than the WT, and the silenced lines had lower AOX (alternative oxidase) activity. As expected, the mitochondrial membrane potential (MMP) was less stable in the SlWHY2 RNAi lines. The expression levels of seven genes in the mitochondrial genome (SYCF15, NAD7, NAD4, COS2, COX1, COX2, and COX3) were decreased even more in the SlWHY2 RNAi lines than they were in the WT under drought stress. SlWHY2 interacted directly in vivo and in vitro with SlRECA2, a mitochondrial recombinase A that is important for mitochondrial DNA recombination and repair. These results suggest that SlWHY2 plays an essential role in maintaining mitochondrial function and enhancing drought tolerance in tomato.
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http://dx.doi.org/10.1016/j.plantsci.2020.110674DOI Listing
December 2020

SlSGRL, a tomato SGR-like protein, promotes chlorophyll degradation downstream of the ABA signaling pathway.

Plant Physiol Biochem 2020 Dec 29;157:316-327. Epub 2020 Oct 29.

State Key Laboratory of Crop Biology, College of Life Science, Shandong Agricultural University, Daizong Street, Tai'an 271018, Shandong, PR China. Electronic address:

Chlorophyll (chl) degradation plays a vital role during green plant growth and development, including nutrient metabolism, fruit and seed maturation, and phototoxic detoxification. STAY-GREEN (SGR) is a plant-specific regulator involved in chl degradation. Previous studies showed that SlSGR1 functioned in chl degradation and lycopene accumulation during fruit ripening of tomato (Solanum lycopersicum). However, little is known about SlSGR-LIKE (SlSGRL) gene, which is a homolog of SlSGR1. We cloned the SlSGRL gene and created transgenic tomato plants overexpressing (OE) SlSGRL. Expression analysis showed that SlSGRL was up-regulated by abscisic acid (ABA). Our data showed that SlSGRL-OE lines exhibited earlier leaf yellowing than wild-type (WT) lines under ABA treatment. Yeast two-hybrid (Y2H) assay revealed that SlSGRL interacted with pheophytin pheophorbide hydrolase (SlPPH) and light-harvesting complex a2 (SlLHCa2) to promote the chl degradation. Further analysis demonstrated that ABA-INSENSITIVE5 (SlABI5) and SlABI5-LIKE regulated SlSGRL expression by directly binding to the sequence (-611 to -582) of the SlSGRL promoter that included an ABRE cis-element. We proposed that SlSGRL, which was regulated by SlABI5/SlABI5-LIKE, mainly acted in ABA-induced chl degradation via interacting with SlPPH and SlLHCa2.
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http://dx.doi.org/10.1016/j.plaphy.2020.10.028DOI Listing
December 2020

Spatial differentiation of gully clusters based on the regional scale: an example from northeastern China.

PeerJ 2020 19;8:e9907. Epub 2020 Oct 19.

Sichuan Provincial Engineering Laboratory of Monitoring and Control for Soil Erosion on Dry Valleys, China West Normal University, Nanchong, China.

Gully erosion represents a serious environmental threat around the world, but their spatial distribution law are unclear at the regional scale. To quantitatively characterize the spatial distribution model of gullies and determine the regularity of regional differentiation, this paper used spatial analyst and statistics method to study the spatial distribution of gullies in 34 sample areas of northeastern China based on interpretations of high-resolution remote sensing images. The results showed that the kernel density could quantitatively describe the continuous spatial clustering of gullies. Gullies in northeastern China had the characteristics of a spatially unbalanced distribution at the scale of the sample area. The average kernel density of the 34 sample areas (Moran's was 0.43, P¡0.01 < 0.01) also indicated clustering distribution at the regional scale. The horizontal clustering characteristics of gullies exhibited an azonal distribution of being low values in the middle plain and high values on the three mountainous areas. The average kernel density in the southeastern part of the study area was highest (maximum value of 2.38). In the vertical direction, gullies were relatively undeveloped in low- and high-altitude areas, while middle-altitude areas were beneficial to the development of gullies. The effect of height differences on gully development was more significant than altitude. As the height difference increased, gullies tended to be more clustered, which can be expressed by a power function. The results of this study will not only help to understand the regional differentiation characteristics of gullies but will also provide a scientific reference for the study of spatial distribution of gullies in future.
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http://dx.doi.org/10.7717/peerj.9907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7580587PMC
October 2020

Cellular and molecular imaging for stem cell tracking in neurological diseases.

Stroke Vasc Neurol 2021 Mar 29;6(1):121-127. Epub 2020 Oct 29.

China National Clinical Research Center for Neurological Diseases, Capital Medical University, Beijing Tiantan Hospital, Beijing, China

Stem cells (SCs) are cells with strong proliferation ability, multilineage differentiation potential and self-renewal capacity. SC transplantation represents an important therapeutic advancement for the treatment strategy of neurological diseases, both in the preclinical experimental and clinical settings. Innovative and breakthrough SC labelling and tracking technologies are widely used to monitor the distribution and viability of transplanted cells non-invasively and longitudinally. Here we summarised the research progress of the main tracers, labelling methods and imaging technologies involved in current SC tracking technologies for various neurological diseases. Finally, the applications, challenges and unresolved problems of current SC tracing technologies were discussed.
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http://dx.doi.org/10.1136/svn-2020-000408DOI Listing
March 2021

Demonstration of intracellular trafficking, cytosolic bioavailability, and target manipulation of an antibody delivery platform.

Nanomedicine 2020 Oct 13;32:102315. Epub 2020 Oct 13.

School of Chemical & Biomolecular Engineering and Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, United States. Electronic address:

Intracellular antibody delivery into live cells has significant implications for research and therapeutic applications. However, many delivery systems lack potency due to low uptake and/or endosomal entrapment and understanding of intracellular delivery processes is lacking. Herein, we studied the cellular uptake, intracellular trafficking and targeting of antibodies using our previously developed Hex antibody nanocarrier. We demonstrated Hex-antibodies were internalized through multiple endocytic routes into lysosomes and provide evidence of endo/lysosomal disruption and Hex-antibody release to the cytosol. Cytosolic antibodies retained their bioactivity for at least 24 h. Functional effect of Hex delivered anti-STAT3 antibodies was evidenced by inhibition of nuclear translocation of cytosolic transcription factor STAT3. This study has generated understanding of key steps in the Hex intracellular antibody delivery system and will facilitate the development of effective cytosolic antibody delivery and applications in both the therapeutic and research domains.
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http://dx.doi.org/10.1016/j.nano.2020.102315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041925PMC
October 2020

Inhibition of Androgen Receptor Signaling Promotes Prostate Cancer Cell Migration via Upregulation of Annexin A1 Expression.

Arch Med Res 2021 02 13;52(2):174-181. Epub 2020 Oct 13.

Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, PR China; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an, PR China; Key Laboratory for Tumor Precision Medicine of Shaanxi Province, Xi'an, PR China. Electronic address:

Background: Recent studies indicate that androgen deprivation therapy (ADT), the main therapeutic approach for metastatic prostate cancer (PCa), accelerates PCa invasion and metastasis. Annexin A1 (ANXA1) is a Ca-regulated phospholipid-binding protein that can promote PCa migration and invasion.

Aim Of The Study: The aim of this study is to determine whether ANXA1 is regulated by ADT and participates in PCa progression after ADT, and to explore the possible mechanism of ANXA1-mediated PCa migration.

Methods: Expression of ANXA1 and androgen receptor (AR) in PCa cell lines and tissues was detected, and the association between these two proteins were analyzed. Expression of ANXA1 was evaluated after AR knockdown or AR inhibition in PCa cell lines. Cell migration of PCa cell liness after ANXA1 knockdown or overexpression was determined by in vitro migration assay. Transcriptome analysis was used to explore the possible mechanism of ANXA1-mediated PCa migration.

Results: ANXA1 expression in PCa cell lines and tissues was reversely associated with AR. In vitro studies revealed an increase in ANXA1 expression after AR knockdown or treatment with AR antagonist. Moreover, functional assays indicated that ANXA1 knockdown in PCa cells significantly inhibited cell migration, while ANXA1 overexpression in PCa cells significantly accelerated cell migration. Transcriptome analysis showed that ANXA1 regulated multiple genes involved in cell junction organization, such as CADM1, LIMCH1 and PPM1F.

Conclusions: Our results indicate that ADT might accelerate PCa metastasis via ANXA1 expression and PCa cell migration.
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http://dx.doi.org/10.1016/j.arcmed.2020.10.005DOI Listing
February 2021

Magnetic anisotropy in square pyramidal cobalt(II) complexes supported by a tetraazo macrocyclic ligand.

Dalton Trans 2020 Nov;49(42):14837-14846

State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.

Two five-coordinate mononuclear Co(ii) complexes [Co(12-TMC)X][B(C6H5)4] (L = 1,4,7,10-tetramethyl-1,4,7,10-tetraazacyclododecane (12-TMC), X = Cl- (1), Br- (2)) have been studied by X-ray single crystallography, magnetic measurements, high-frequency and -field EPR (HF-EPR) spectroscopy and theoretical calculations. Both complexes have a distorted square pyramidal geometry with the Co(ii) ion lying above the basal plane constrained by the rigid tetradentate macrocyclic ligand. In contrast to the reported five-coordinate Co(ii) complex [Co(12-TMC)(NCO)][B(C6H5)4] (3) exhibiting easy-axis anisotropy, an easy-plane magnetic anisotropy was found for 1 and 2via the analyses of the direct-current magnetic data and HF-EPR spectroscopy. Frequency- and temperature-dependent alternating-current magnetic susceptibility measurements demonstrated that complexes 1 and 2 show slow magnetic relaxation at an applied dc field. Ab initio calculations were performed to reveal the impact of the terminal ligands on the nature of the magnetic anisotropies of this series of five-coordinate Co(ii) complexes.
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http://dx.doi.org/10.1039/d0dt01954bDOI Listing
November 2020

LncLocation: Efficient Subcellular Location Prediction of Long Non-Coding RNA-Based Multi-Source Heterogeneous Feature Fusion.

Int J Mol Sci 2020 Oct 1;21(19). Epub 2020 Oct 1.

Key Laboratory of Symbol Computation and Knowledge Engineering of Ministry of Education, College of Computer Science and Technology, Jilin University, Changchun 130012, China.

Recent studies uncover that subcellular location of long non-coding RNAs (lncRNAs) can provide significant information on its function. Due to the lack of experimental data, the number of lncRNAs is very limited, experimentally verified subcellular localization, and the numbers of lncRNAs located in different organelle are wildly imbalanced. The prediction of subcellular location of lncRNAs is actually a multi-classification small sample imbalance problem. The imbalance of data results in the poor recognition effect of machine learning models on small data subsets, which is a puzzling and challenging problem in the existing research. In this study, we integrate multi-source features to construct a sequence-based computational tool, lncLocation, to predict the subcellular location of lncRNAs. Autoencoder is used to enhance part of the features, and the binomial distribution-based filtering method and recursive feature elimination (RFE) are used to filter some of the features. It improves the representation ability of data and reduces the problem of unbalanced multi-classification data. By comprehensive experiments on different feature combinations and machine learning models, we select the optimal features and classifier model scheme to construct a subcellular location prediction tool, lncLocation. LncLocation can obtain an 87.78% accuracy using 5-fold cross validation on the benchmark data, which is higher than the state-of-the-art tools, and the classification performance, especially for small class sets, is improved significantly.
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http://dx.doi.org/10.3390/ijms21197271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582431PMC
October 2020

Intercalation-Induced Conversion Reactions Give High-Capacity Potassium Storage.

ACS Nano 2020 Oct 5;14(10):14026-14035. Epub 2020 Oct 5.

Shenzhen Geim Graphene Center, Tsinghua-Berkeley Shenzhen Institute & Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.

Potassium ion batteries (PIBs) have shown great potential as a next-generation electrochemical energy storage system, due to the natural abundance of potassium and the relatively low redox potential of K ions. To accommodate the large ionic radius of K ions, conversion-type electrode materials are regarded as suitable candidates for K ion storage. However, the triggering mechanism of a conversion reaction in most anode materials of PIBs is unclear, which limits their further development. To reveal the mechanism, in this work, MoSe, MoS, and MoO were selected as model materials, guided by theoretical calculations, to investigate the K ion storage process. Through characterization, it was found that intercalation reactions preferentially occur in MoSe and MoS, while an adsorption reaction preferentially occurs in MoO. This is because of the larger interlayer spacing and lower K ion intercalation barrier in MoSe and MoS than in MoO. The preferential intercalation reactions are able to induce a further conversion reaction by reducing the reaction barrier, thereby realizing high K ion storage capacities. As a result, the MoSe-rGO and MoS-rGO hybrids showed higher reversible capacities than the MoO-rGO hybrid. By demonstrating a relationship between intercalation and the conversion reaction and understanding the mechanism, guidance is provided for selecting the electrode materials to obtain PIBs with high performance.
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http://dx.doi.org/10.1021/acsnano.0c06606DOI Listing
October 2020