Publications by authors named "Wei Liu"

9,511 Publications

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Changes of microbial community structure during the initial stage of biological clogging in horizontal subsurface flow constructed wetlands.

Bioresour Technol 2021 Jun 12;337:125405. Epub 2021 Jun 12.

State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.

The clogging is a universal problem in constructed wetlands, where microorganisms play an essential role. However, the implication of micro-organism variation due to the clogging is not clear. Four horizontal subsurface flow constructed wetlands (HFCWs) were designed and operated to simulate the process of clogging. The wetland treatment performance and microbial community variation were investigated by regularly monitoring. Results showed the substrate filtration rate and the total phosphorous (TP) removal efficiency consistently decreased and the chemical oxygen demand (COD) and total nitrogen (TN) removal efficiency were at the range of 50%-85% and 10-20%, respectively. The sequencing results indicated that the clogging could affect the richness of bacterial community. The bacterial variation could be attributed to the dissolved oxygen decreasing and organic matter accumulation in the initial clogging period. These findings are expected to provide some theoretical reference for developing the biological methods to indicate the initial clogging in constructed wetlands.
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http://dx.doi.org/10.1016/j.biortech.2021.125405DOI Listing
June 2021

Fabricating Silicon Nanotubes by Electrochemical Exfoliation and Reduction of Layer-Structured CaSiO in Molten Salt.

ACS Appl Mater Interfaces 2021 Jun 24. Epub 2021 Jun 24.

School of Resource and Environmental Sciences, Hubei International Scientific and Technological Cooperation Base of Sustainable Resource and Energy, Wuhan University, Wuhan 430072, P. R. China.

Silicon nanotubes (SNTs) are very attractive in the fields of energy, catalysis, and sensors, but a facile template- and/or catalyst-free preparation method is still absent. Herein, we study a controllable and cost-effective approach for preparing SNTs by electrochemically reducing layer-structured calcium silicate (CaSiO) in molten CaCl/NaCl without any template and catalyst. The underlying mechanism of the SNT formation is uncovered: the layer-structured CaSiO is first electrochemically exfoliated into SiO (0 < < 2) sheets while releasing CaO into the molten salts, and then the SiO sheets are electrochemically reduced and simultaneously crimped into SNTs. The diameter (120-312 nm) and wall thickness (∼40 nm) of the SNTs can be tailorable by manipulating the reduction potential between -1.28 and -1.48 V (vs Ag/AgCl). Lastly, the electrolytic SNTs show a high lithium storage capacity of 3737 mAh g at 0.2 A g, a high rate capability of 1371 mA h g at 10 A g, and stable cycling with a capacity of 974 mAh g after 600 cycles at 1 A g. Overall, the template- and catalyst-free electrochemical method provides a straightforward and facile way to prepare SNTs with a brand-new mechanism that can be applied to other tubular structure materials.
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http://dx.doi.org/10.1021/acsami.1c07031DOI Listing
June 2021

LncRNA XIST is involved in rheumatoid arthritis fibroblast-like synoviocytes by sponging miR-126-3p via the NF-κB pathway.

Autoimmunity 2021 Jun 24:1-10. Epub 2021 Jun 24.

Department of Rheumatology and Immunology, the First hospital of Qiqihar City, Qiqihar City, PR China.

The role and mechanism of lncRNA XIST (XIST) in the development of rheumatoid arthritis (RA) was explored in this study. RT-qPCRs were performed to detect the expression of XIST and miR-126-3p in synovial tissues and cells. Target gene prediction and luciferase gene reporter assay were used to validate downstream target genes of XIST. MTT assay, EdU staining and Annexin V/PI staining were performed to explore the effects of XIST and miR-126-3p on cell proliferation and apoptosis. Western blotting analysis was used to detect the expression of related proteins. We found that the expression levels of XIST in tissues and cells were significantly higher than that in normal tissues and cells. Down-regulation of XIST could inhibit cell proliferation rate and increase apoptosis rate. Luciferase gene reporter assay showed that miR-126-3p was a downstream target gene of XIST. Overexpression of miR-126-3p significantly inhibited RA-FLS cell proliferation and induced RA-FLS cell apoptosis. In addition, down-regulation of XIST could increase the ratio of caspase-3 and Bax/Bcl-2. In addition, overexpression of miR-126-3p could inhibit the NF-κB signalling pathway by reducing the expression levels of p-p65 and p-IκBα in RA-FLS cells. In conclusion, down-regulation of XIST can inhibit the proliferation of synovial fibroblasts by increasing the expression levels of miR-126-3p/NF-κB, thereby inhibiting the occurrence and development of RA.
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http://dx.doi.org/10.1080/08916934.2021.1937608DOI Listing
June 2021

Absorption, metabolism, excretion, and safety of [C]almonertinib in healthy Chinese subjects.

Ann Transl Med 2021 May;9(10):867

Phase I Clinical Trial Unit, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Background: Almonertinib Mesilate Tablets (HS-10296, Hansoh Pharma, Shanghai, China) is a novel and selective third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI). A phase I study of almonertinib in patients with non-small cell lung cancer (NSCLC) demonstrated a linear metabolic trend, a good tolerability/safety profile, and preliminary antitumor activity. However, the metabolism, excretion, and substance balance of almonertinib has not been clearly determined. Here, we investigated the pharmacokinetic characteristics and safety profile of almonertinib following a single oral dose (110 mg/50 µCi) in healthy Chinese male participants.

Methods: Total radioactivity (TRA) in whole blood, plasma, urine, and feces was measured by utilizing a liquid scintillation counter to obtain almonertinib substance balance data. The pharmacokinetic parameters of [C]almonertinib and the parent drug almonertinib in whole blood and plasma were analyzed with noncompartmental analysis in the WinNonlin software (Pharsight Corp). The major metabolites in plasma, urine, and feces were analyzed by high-performance liquid chromatography (HPLC) coupled with an online or offline isotope detector. The safety of the drug was evaluated after administration.

Results: The safety and tolerability of a single oral dose of 110 mg/50 µCi [C] almonertinib suspension were good in healthy Chinese male participants. There was no significant abnormality or special adverse reaction. TRA peaked quickly in plasma, with a T of 4.0 h; however, TRA was cleared slowly , with a mean terminal elimination phase (half-life, T) of up to 863 h. In addition to the parent drug, a total of 26 metabolites in blood, urine, and feces were analyzed. In plasma, parent drug was the major drug-related component, accounting for 69.97% of TRA, and M440 (almonertinib-M2 demethyl product) was the major metabolite, accounting for 5.08% of TRA; in urine, parent drug accounted for 0.48% of the dose administered and HAS-719 was the major metabolite, accounting for 1.20% of the administered dose; in feces, parent drug was about 8.61% of the dose administered and HAS-719 was the major metabolite, accounting for 12.33% of the administered dose, which was followed by M541a/M470a and M617/M575, accounting for 11.8% and 6.76% of the administered dose, respectively.

Conclusions: Almonertinib has a good safety profile, with parent drug as its main circulating component. almonertinib is extensively metabolized before excretion and is excreted as a parent drug and metabolites mainly via feces.

Trial Registration: The trial registration number: CTR20192291.
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http://dx.doi.org/10.21037/atm-21-1606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184462PMC
May 2021

Long non-coding RNA X-inactive specific transcript promotes osteosarcoma metastasis via modulating microRNA-758/Rab16.

Ann Transl Med 2021 May;9(10):841

Department of Orthopedics Trauma, Nanhua Hospital Affiliated to Nanhua University, Hengyang, China.

Background: As a common malignant bone sarcoma, osteosarcoma (OS) affects the health and lives of many people. Here, we probed the effects of long non-coding RNA (lncRNA) X-inactive specific transcript (XIST) and microRNA-758 (miR-758) on OS metastasis, and examined possible downstream effector.

Methods: Quantitative reverse transcription PCR (qRT-PCR) was performed to detect the expressions of XIST and miR-758 in OS tissues and cells. Cell transfection was carried out to alter the levels of XIST and miR-758 in OS cells, and cell viability, migration, and invasion were assessed. Subsequently, qRT-PCR and a dual-luciferase reporter assay were conducted to analyze the regulatory effects of XIST on miR-758 and miR-758 on Rab16. Finally, we investigated whether Rab16 was the downstream effector of XIST/miR-758 axis.

Results: XIST was highly expressed in OS tissues and cells, but the opposite was seen for miR-758. In OS cells, migration, invasion, and epithelial-mesenchymal transformation (EMT) was promoted by overexpression of XIST and miR-758 inhibitor, but were inhibited by XIST knockdown and miR-758 mimics. XIST regulated miR-758 expression, and miR-758 regulated Rab16 expression in OS cells. Overexpression of Rab16 reversed the effects of miR-758 mimics on OS cell migration and invasion.

Conclusions: XIST contributed to OS cell migration, invasion, and EMT via regulation of miR-758/Rab16.
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http://dx.doi.org/10.21037/atm-21-1032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184472PMC
May 2021

SIRT1 coordinates with the CRL4B complex to regulate pancreatic cancer stem cells to promote tumorigenesis.

Cell Death Differ 2021 Jun 23. Epub 2021 Jun 23.

Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.

Pancreatic cancer is a common malignant tumor with poor prognosis. Recently, cancer stem cells (CSCs) were identified in several solid tumors, including pancreatic cancer. Although accumulating evidence indicates that sirtuin 1 (SIRT1) exerts biological functions in various cancers, how it contributes to tumorigenesis and metastasis of pancreatic cancer, as well as its role in CSCs, is still poorly defined. Here we show that SIRT1 interacts with the Cullin 4B (CUL4B)-Ring E3 ligase (CRL4B) complex, which is responsible for H2AK119 monoubiquitination (H2AK119ub1), collaborating as a functional unit. Genome-wide analysis of SIRT1/CUL4B targets identified a cohort of genes, including GRHL3 and FOXO3, critically involved in cell differentiation, growth, and migration. Furthermore, we found that SIRT1 and CUL4B collectively promote the proliferation, autophagy, and invasion of pancreatic cancer cells. Remarkably, we demonstrate that SIRT1/CUL4B promotes CSC-like properties, including increased stemness marker expression and sphere formation. In vivo experiments implied that SIRT1 promoted established tumor xenograft growth, increased tumor-initiating capacity in NOD/SCID mice, and increased CSC frequency. Strikingly, SIRT1 and CUL4B expression is markedly upregulated in a variety of human cancers, including pancreatic cancer. Our data provide a molecular basis for the functional interplay between histone deacetylation and ubiquitination. The results also implicate the SIRT1/CRL4B complex in pancreatic cancer metastasis and stem cell properties, thus supporting SIRT1 as a promising potential target for cancer therapy development.
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http://dx.doi.org/10.1038/s41418-021-00821-zDOI Listing
June 2021

Observer-Based Adaptive Optimized Control for Stochastic Nonlinear Systems With Input and State Constraints.

IEEE Trans Neural Netw Learn Syst 2021 Jun 23;PP. Epub 2021 Jun 23.

In this work, an adaptive neural network (NN) optimized output-feedback control problem is studied for a class of stochastic nonlinear systems with unknown nonlinear dynamics, input saturation, and state constraints. A nonlinear state observer is designed to estimate the unmeasured states, and the NNs are used to approximate the unknown nonlinear functions. Under the framework of the backstepping technique, the virtual and actual optimal controllers are developed by employing the actor-critic architecture. Meanwhile, the tan-type Barrier optimal performance index functions are developed to prevent the nonlinear systems from the state constraints, and all the states are confined within the preselected compact sets all the time. It is worth mentioning that the proposed optimized control is clearly simple since the reinforcement learning (RL) algorithm is derived based on the negative gradient of a simple positive function. Furthermore, the proposed optimal control strategy ensures that all the signals in the closed-loop system are bounded. Finally, a practical simulation example is carried out to further illustrate the effectiveness of the proposed optimal control method.
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http://dx.doi.org/10.1109/TNNLS.2021.3087796DOI Listing
June 2021

Cordycepin inhibits inflammatory responses through suppression of ERK activation in zebrafish.

Dev Comp Immunol 2021 Jun 19:104178. Epub 2021 Jun 19.

College of Animal Science and Technology, Anhui Agricultural University, No. 130 Changjiang West Road, Hefei 230036, China; Anhui Province Key Laboratory of Local Livestock and Poultry Genetic Resource Conservation and Bio-breeding, College of Animal Science and Technology, Anhui Agricultural University, Hefei, 230036, China. Electronic address:

As a natural extract, cordycepin has been shown to play important regulatory roles in many life activities. In the study, the effects of cordycepin on inflammatory responses and the underlying mechanisms was explored using a zebrafish model. In the model of LPS-induced inflammation, cordycepin was found to significantly inhibited the expression of pro-inflammatory cytokines such as tnf-α, il-1β, il-6, and il-8. Using in vivo imaging model, cordycepin significantly inhibited fluorescent-labeled neutrophils migrating towards injury sites. Furthermore, results showed that the phosphorylation level of ERK protein dramatically decreased after cordycepin treatment. Meanwhile, the ERK inhibitor, PD0325901, significantly inhibited the expression of pro-inflammatory cytokines in LPS-induced inflammatory model and neutrophils migration in the caudal fin injury model. This study indicated the important roles of cordycepin in inhibiting LPS and injury-induced inflammation and preliminarily explained the role of ERK protein in this process.
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http://dx.doi.org/10.1016/j.dci.2021.104178DOI Listing
June 2021

Outdoor Sunscreen Testing with High-intensity Solar Exposure in a Chinese and Caucasian Population.

Photodermatol Photoimmunol Photomed 2021 Jun 22. Epub 2021 Jun 22.

Department of Dermatology, Henry Ford Hospital, Detroit, Michigan, USA.

Background: Currently, sunscreens' sun protection factor (SPF) and ultraviolet (UV) A protection are tested separately under indoor conditions, without considering external conditions that may affect performance. Studies are often conducted in Caucasian individuals; other racial groups may respond differently.

Methods: An outdoor, double-blind, intra-individual study was performed in 63 healthy Chinese and Caucasian volunteers in Singapore. Subjects underwent one outdoor sun exposure lasting 2-3 hours. ISO reference products P3 (SPF 15), P5 (SPF 30) and P8 (SPF 50+) applied at 2 mg/cm were compared against each other and against an untreated exposed area (positive control) and an unexposed area (negative control). Endpoints were investigator global assessment (IGA) of erythema at 24 hours, IGA of pigmentation at 1 week, and colorimetry (a*, L* and ITA) at 24 hours and 1 week.

Results: Clinical erythema and pigmentation scores were statistically significantly different among the three sunscreens, with the highest SPF product providing the highest protection, confirming the discriminatory capacity of the model used. Colorimetric assessment correlated well with clinical evaluation.

Conclusion: This study confirmed the feasibility of ranking sunscreens (at 2 mg/cm ) based on clinical effects of high-intensity outdoor solar radiation. Larger studies are needed to look at differences in erythema and pigmentation reactions between Chinese and Caucasian individuals, which could be relevant for photoprotection.
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http://dx.doi.org/10.1111/phpp.12710DOI Listing
June 2021

Incorporation of an Emissive CuI Core into Cross-Linked Networks: An Effective Strategy for Luminescent Organic-Inorganic Hybrid Coatings.

Inorg Chem 2021 Jun 22. Epub 2021 Jun 22.

School of Chemical Engineering and Technology, Sun Yat-Sen University, Zhuhai 519082, China.

Here, an effective strategy for the preparation of luminescent organic-inorganic hybrid coatings (OIHCs) by the incorporation of an emissive CuI core into cross-linked coating networks through coordination bonds is reported. The luminescent coatings obtained show potential application in a variety of areas, and such a synthetic strategy of the incorporation of an emissive inorganic core into extended networks has proven to be an efficient method for the synthesis of luminescent OIHCs.
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http://dx.doi.org/10.1021/acs.inorgchem.1c00909DOI Listing
June 2021

SPR sensor based on Bessel-like beam.

Opt Express 2021 Jun;29(12):18305-18314

A proposal toward the enhancement in the sensitivity of a fiber-based surface plasma resonance (SPR) refractive index (RI) sensor is explored experimentally using a Bessel-like beam as the input source. We splice a section of single-mode fiber and a section of multimode fiber to construct the Bessel-like beam, which contains a series of concentric rings for the consistency of the resonance angle configuration to improve the performance of the SPR sensor. We fabricate a dual-truncated-cone (DTC) structure of the fiber to excite and receive the SPR signals. The larger the number of concentric rings, the higher the sensitivity. The number of concentric ring is determined by the length of the multimode fiber. When the grinding angle of the DTC-sensing probe is 15 and the length of the multimode fiber is 500 µm, the maximum testing average sensitivity is 6908.3 nm/RIU, which is more sensitive than the previous SPR sensor introduced by the Gaussian beam as the input source in multimode fibers.
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http://dx.doi.org/10.1364/OE.423760DOI Listing
June 2021

Effect of Adrenocorticotropic Hormone Stimulation During Simultaneous Bilateral Adrenal Vein Sampling in Primary Aldosteronism.

Horm Metab Res 2021 Jun 21;53(6):364-370. Epub 2021 Jun 21.

National Clinical Research Center for Metabolic Diseases, Institute of Metabolism and Endocrinology, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Hunan, China.

The aim of the study was to investigate the significance and influence of adrenocorticotropic hormone (ACTH) stimulation in primary aldosteronism (PA) patients with simultaneous bilateral adrenal vein sampling (AVS). All patients diagnosed with PA underwent simultaneous bilateral AVS with ACTH. In 95 patients, the post-ACTH SI significantly increased (p<0.001), and it gradually decreased from t10-t30 after ACTH stimulation (p<0.001). The unsuccessful catheterization decreased after ACTH stimulation. Time points within 20 min after ACTH stimulation were better for sampling, and the selectivity did not increase over longer periods. According to lateralization before and after ACTH stimulation, the patients could be divided into 3 groups (U, unilateral; B, bilateral): U/U , U/B or B/U, and B/B. Compared with the U/U group, in the U/B or B/U and B/B groups, the lateralization index (LI) was lower both at baseline and after ACTH stimulation (p<0.0001), the contralateral index (CLI) was higher after ACTH stimulation (p<0.003), the serum potassium level was higher (p<0.001), and the carbon dioxide combining power (CO2CP) and base excess (BE) levels were lower. In conclusion, in simultaneous bilateral AVS, ACTH stimulation had significant effects on increasing the catheterization selectivity. Lateralization change was observed after stimulation. After ACTH stimulation, fewer patients could be diagnosed with lateralized PA. Patients with consistent lateralized PA showed a more serious phenotype.
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http://dx.doi.org/10.1055/a-1498-6958DOI Listing
June 2021

Effective oral delivery of Exenatide-Zn complex through distal ileum-targeted double layers nanocarriers modified with deoxycholic acid and glycocholic acid in diabetes therapy.

Biomaterials 2021 Jun 7;275:120944. Epub 2021 Jun 7.

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. Electronic address:

The oral administration route is popular with T2DM patients because they need convenience in lifelong medication. At present, oral Exenatide is not available on the market and therefore the relevant studies are valuable. Herein, we constructed a novel dual cholic acid-functionalized nanoparticle for oral delivery of Exenatide, which was based on the functionalized materials of deoxycholic acid-low molecular weight protamine and glycocholic acid-poly (ethylene glycol)-b-polysialic acid. The hydrophobic deoxycholic acid strengthened the nanoparticles and the hydrophilic glycolic acid targeted to specific transporter. We first condensed Exenatide-Zn complex with deoxycholic acid-low molecular weight protamine to prepare nanocomplexes with ζ-potentials of +8 mV and sizes of 95 nm. Then, we used glycocholic acid-poly (ethylene glycol)-b-polysialic acid copolymers masking the positive charge of nanocomplexes to prepare nanoparticles with negative charges of -22 mV and homogeneous sizes of 140 nm. As a result, this dual cholic acid-functionalized nanoparticle demonstrated enhanced uptake and transport of Exenatide, and a special targeting to apical sodium-dependent cholic acid transporter in vitro. Moreover, in vivo studies showed that the nanoparticle effectively accumulated in distal ileum, raised the plasma concentration of Exenatide, prolonged hypoglycemic effect, reduced blood lipid levels, and lightened organ lesions.
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http://dx.doi.org/10.1016/j.biomaterials.2021.120944DOI Listing
June 2021

PPARγ mediates the anti-pulmonary fibrosis effect of icaritin.

Toxicol Lett 2021 Jun 18. Epub 2021 Jun 18.

Xiangya Nursing School, Central South University, Changsha, Hunan, China. Electronic address:

Background: Pulmonary fibrosis is a fatal lung disease with limited treatment options. Icaritin is the active ingredient derived from the traditional Chinese medical plant Epimedium and possesses many biomedical activities. This study aimed to investigate the effects and molecular mechanisms of icaritin on bleomycin-induced pulmonary fibrosis in mice.

Methods: To assess its preventative effects, bleomycin treated mice received 0, 0.04, 0.2, and 1 mg/kg of icaritin from day 1 onwards. To assess its therapeutic effects, bleomycin treated mice received 0 and 1 mg/kg of icaritin from day 15 onwards. Mice were sacrificed on day 21 and lung tissues were collected, stained with HE, Masson and immunohistochemistry. Q-PCR was used to measure Collagen I and Collagen III expression, western blotting was used to quantify α-SMA, Collagen I expression. Hydroxyproline content was measured using a biochemical method. NIH3T3 and HLF-1 cells were treated with TGF-β1with or without icaritin, and α-SMA, Collagen I were tested. PPARγ antagonist GW9662 and PPARγ-targeted siRNA were used to investigate the mechanism of icaritin in inhibiting myofibroblast differentiation.

Results: Both preventative and therapeutic administration of icaritin improved the histopathological changes, decreased Collagen and α-SMA, lowered hydroxyproline content in bleomycin-treated lung tissues. Icaritin decreased α-SMA and Collagen I expression in TGF-β1-stimulated NIH3T3 and HLF-1 cells. However, its effect in reducing α-SMA and Collagen I expression was suppressed when expression or activity of PPARγ was inhibited.

Conclusions: Icaritin has therapeutic potential against pulmonary fibrosis via the inhibition of myofibroblast differentiation, which may be mediated by PPARγ.
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http://dx.doi.org/10.1016/j.toxlet.2021.06.014DOI Listing
June 2021

Drug-drug interaction comparison between Tacrolimus and Phenobarbital in different formulations for pediatrics and adults.

Xenobiotica 2021 Jun 21:1-29. Epub 2021 Jun 21.

Tianjin Children's Hospital, Tianjin, China.

To compare drug-drug interaction (DDI) between tacrolimus and different formulations of phenobarbital in pediatrics and adults.Physiologically-based pharmacokinetics (PBPK) models were used to evaluate DDI between phenobarbital (oral (p.o.) and intravenous (i.v.) formulations) and tacrolimus in pediatrics and adults. All dosing regimens were maintained for 7 days.Compared to i.v. phenobarbital, p.o. phenobarbital could decrease pharmacokinetic (PK) parameters of tacrolimus much more in both pediatrics and adults. On day 7, the results showed that the ratio of C for tacrolimus in the presence and absence of phenobarbital were 0.13 (p.o.) and 0.48 (i.v.) respectively in pediatrics, while 0.54 (p.o.) and 0.73 (i.v.) in adults, respectively. The ratios of the area under the concentration-time curve (AUC) were 0.06 (p.o.) and 0.18 (i.v.) in pediatrics, while 0.46 (p.o.) and 0.53 (i.v.) in adults, respectively. PK parameters of tacrolimus decreased more significantly in pediatrics compared to adults.In pediatric, phenobarbital had a greater impact on PK of tacrolimus than that in adults. P.o. phenobarbital reduced PK parameters of tacrolimus even more than i.v. administration. In clinical practice, the concentration monitoring and dosage adjustment of tacrolimus should be emphasized when co-administrated with phenobarbital, especially in pediatric or in p.o. formulation. The results indicated that p.o. and i.v. phenobarbital both had a significant DDI with tacrolimus in pediatrics and adults. Phenobarbital had a greater impact on the PK of tacrolimus over time in pediatrics. P.o. administration of phenobarbital can reduce the PK parameters of tacrolimus more.
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http://dx.doi.org/10.1080/00498254.2021.1943564DOI Listing
June 2021

Spatially Bandgap-Graded MoSSe Homojunctions for Self-Powered Visible-Near-Infrared Phototransistors.

Nanomicro Lett 2020 Jan 18;12(1):26. Epub 2020 Jan 18.

Department of Electronic and Electrical Engineering, University College London, Torrington Place, London, WC1E 7JE, UK.

Ternary transition metal dichalcogenide alloys with spatially graded bandgaps are an emerging class of two-dimensional materials with unique features, which opens up new potential for device applications. Here, visible-near-infrared and self-powered phototransistors based on spatially bandgap-graded MoSSe alloys, synthesized by a simple and controllable chemical solution deposition method, are reported. The graded bandgaps, arising from the spatial grading of Se composition and thickness within a single domain, are tuned from 1.83 to 1.73 eV, leading to the formation of a homojunction with a built-in electric field. Consequently, a strong and sensitive gate-modulated photovoltaic effect is demonstrated, enabling the homojunction phototransistors at zero bias to deliver a photoresponsivity of 311 mA W, a specific detectivity up to ~ 10 Jones, and an on/off ratio up to ~ 10. Remarkably, when illuminated by the lights ranging from 405 to 808 nm, the biased devices yield a champion photoresponsivity of 191.5 A W, a specific detectivity up to ~ 10 Jones, a photoconductive gain of 10-10, and a photoresponsive time in the order of ~ 50 ms. These results provide a simple and competitive solution to the bandgap engineering of two-dimensional materials for device applications without the need for p-n junctions.
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http://dx.doi.org/10.1007/s40820-019-0361-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7770748PMC
January 2020

Cell Membrane Coating Technology: A Promising Strategy for Biomedical Applications.

Nanomicro Lett 2019 Nov 16;11(1):100. Epub 2019 Nov 16.

Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, People's Republic of China.

Cell membrane coating technology is an approach to the biomimetic replication of cell membrane properties, and is an active area of ongoing research readily applicable to nanoscale biomedicine. Nanoparticles (NPs) coated with cell membranes offer an opportunity to unite natural cell membrane properties with those of the artificial inner core material. The coated NPs not only increase their biocompatibility but also achieve effective and extended circulation in vivo, allowing for the execution of targeted functions. Although cell membrane-coated NPs offer clear advantages, much work remains before they can be applied in clinical practice. In this review, we first provide a comprehensive overview of the theory of cell membrane coating technology, followed by a summary of the existing preparation and characterization techniques. Next, we focus on the functions and applications of various cell membrane types. In addition, we collate model drugs used in cell membrane coating technology, and review the patent applications related to this technology from the past 10 years. Finally, we survey future challenges and trends pertaining to this technology in an effort to provide a comprehensive overview of the future development of cell membrane coating technology.
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http://dx.doi.org/10.1007/s40820-019-0330-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7770915PMC
November 2019

Rational Design of Layered SnS on Ultralight Graphene Fiber Fabrics as Binder-Free Anodes for Enhanced Practical Capacity of Sodium-Ion Batteries.

Nanomicro Lett 2019 Aug 3;11(1):66. Epub 2019 Aug 3.

College of Aerospace Engineering, The State Key Laboratory of Mechanical Transmissions, Chongqing University, Chongqing, 400044, People's Republic of China.

Generally, the practical capacity of an electrode should include the weight of non-active components such as current collector, polymer binder, and conductive additives, which were as high as 70 wt% in current reported works, seriously limiting the practical capacity. This work pioneered the usage of ultralight reduced graphene fiber (rGF) fabrics as conductive scaffolds, aiming to reduce the weight of non-active components and enhance the practical capacity. Ultrathin SnS nanosheets/rGF hybrids were prepared and used as binder-free electrodes of sodium-ion batteries (SIBs). The interfused graphene fibers endow the electrode a porous, continuous, and conductive network. The in situ phase transformation from SnO to SnS could preserve the strong interfacial interactions between SnS and graphene. Benefitting from these, the designed binder-free electrode delivers a high specific capacity of 500 mAh g after 500 cycles at a current rate of 0.5 A g with almost 100% Coulombic efficiency. Furthermore, the weight percentage of SnS in the whole electrode could reach up to 67.2 wt%, much higher than that of common electrode configurations using Cu foil, Al foil, or carbon cloth, significantly highlighting the ultralight characters and advantages of the rGF fabrics for using as binder-free electrodes of SIBs.
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http://dx.doi.org/10.1007/s40820-019-0297-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7770950PMC
August 2019

Lead-Free Halide Double Perovskite Materials: A New Superstar Toward Green and Stable Optoelectronic Applications.

Nanomicro Lett 2019 Feb 27;11(1):16. Epub 2019 Feb 27.

New Energy Technology Engineering Laboratory of Jiangsu Province & School of Science, Nanjing University of Posts and Telecommunications (NJUPT), Nanjing, 210023, People's Republic of China.

Lead-based halide perovskites have emerged as excellent semiconductors for a broad range of optoelectronic applications, such as photovoltaics, lighting, lasing and photon detection. However, toxicity of lead and poor stability still represent significant challenges. Fortunately, halide double perovskite materials with formula of AM(I)M(III)X or AM(IV)X could be potentially regarded as stable and green alternatives for optoelectronic applications, where two divalent lead ions are substituted by combining one monovalent and one trivalent ions, or one tetravalent ion. Here, the article provides an up-to-date review on the developments of halide double perovskite materials and their related optoelectronic applications including photodetectors, X-ray detectors, photocatalyst, light-emitting diodes and solar cells. The synthesized halide double perovskite materials exhibit exceptional stability, and a few possess superior optoelectronic properties. However, the number of synthesized halide double perovskites is limited, and more limited materials have been developed for optoelectronic applications to date. In addition, the band structures and carrier transport properties of the materials are still not desired, and the films still manifest low quality for photovoltaic applications. Therefore, we propose that continuing efforts are needed to develop more halide double perovskites, modulate the properties and grow high-quality films, with the aim of opening the wild practical applications.
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http://dx.doi.org/10.1007/s40820-019-0244-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7770810PMC
February 2019

Biomass-Derived Porous Carbon-Based Nanostructures for Microwave Absorption.

Nanomicro Lett 2019 Mar 15;11(1):24. Epub 2019 Mar 15.

School of Materials Sciences and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore, 639798, Singapore.

Currently, electromagnetic (EM) pollution poses severe complication toward the operation of electronic devices and biological systems. To this end, it is pertinent to develop novel microwave absorbers through compositional and structural design. Porous carbon (PC) materials demonstrate great potential in EM wave absorption due to their ultralow density, large surface area, and excellent dielectric loss ability. However, the large-scale production of PC materials through low-cost and simple synthetic route is a challenge. Deriving PC materials through biomass sources is a sustainable, ubiquitous, and low-cost method, which comes with many desired features, such as hierarchical texture, periodic pattern, and some unique nanoarchitecture. Using the bio-inspired microstructure to manufacture PC materials in mild condition is desirable. In this review, we summarize the EM wave absorption application of biomass-derived PC materials from optimizing structure and designing composition. The corresponding synthetic mechanisms and development prospects are discussed as well. The perspective in this field is given at the end of the article.
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http://dx.doi.org/10.1007/s40820-019-0255-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7770762PMC
March 2019

De novo donor-specific HLA antibodies reduce graft survival rates and increase the risk of kidney transplant rejection: A single-center retrospective study.

Transpl Immunol 2021 Jun 18;68:101430. Epub 2021 Jun 18.

Department of Blood Transfusion, Tianjin First Central Hospital, Tianjin, China. Electronic address:

Background: We investigated the impact of de novo donor-specific anti-human leukocyte antigen antibodies (dnDSAs) on long-term death-censored graft survival and renal allograft rejection in kidney transplant recipients.

Methods: The sample for this retrospective cohort study comprised 121 recipients of kidney transplants with negative complement-dependent cytotoxicity crossmatches to their deceased donors. Recipients were divided into two groups: dnDSAs+ (n = 31) and dnDSAs- (n = 90). We evaluated rejection and long-term graft survival rates in the recipients along with pathologic changes in the transplanted kidneys.

Results: DnDSAs were identified in 31/121 patients (25.6%). The graft survival rate in the dnDSAs+ group was 87.1% (27/31) and that of the dnDSAs- group was 97.8% (88/90). The dnDSAs+ group had lower graft survival rates than patients without dnDSAs (p = 0.007). There was no difference in the graft survival rates between patients with high DSA mean fluorescence intensity (≥4000) and those with low intensity (<4000) (p = 0.669). There was also no difference in the graft survival rates of patients with HLA class I, II, and I + II dnDSAs (p = 0.571). The presence of dnDSA in serum was associated with a higher incidence of antibody- and T-cell-mediated rejection (p < 0.0001). Banff scores for arterial fibrointimal and arteriolar hyalin, thickening as well as C4d deposition differed for the dnDSAs+ and dnDSAs- groups (p < 0.05).

Conclusion: DnDSAs were found to be associated with decreased long-term graft survival rates and increased rejection rates, often accompanied by C4d deposition.
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http://dx.doi.org/10.1016/j.trim.2021.101430DOI Listing
June 2021

Estimation of in-scanner head pose changes during structural MRI using a convolutional neural network trained on eye tracker video.

Magn Reson Imaging 2021 Jun 17. Epub 2021 Jun 17.

Comprehensive Epilepsy Center, Department of Neurology, NYU Grossman School of Medicine, New York, USA.

Introduction: In-scanner head motion is a common cause of reduced image quality in neuroimaging, and causes systematic brain-wide changes in cortical thickness and volumetric estimates derived from structural MRI scans. There are few widely available methods for measuring head motion during structural MRI. Here, we train a deep learning predictive model to estimate changes in head pose using video obtained from an in-scanner eye tracker during an EPI-BOLD acquisition with participants undertaking deliberate in-scanner head movements. The predictive model was used to estimate head pose changes during structural MRI scans, and correlated with cortical thickness and subcortical volume estimates.

Methods: 21 healthy controls (age 32 ± 13 years, 11 female) were studied. Participants carried out a series of stereotyped prompted in-scanner head motions during acquisition of an EPI-BOLD sequence with simultaneous recording of eye tracker video. Motion-affected and motion-free whole brain T1-weighted MRI were also obtained. Image coregistration was used to estimate changes in head pose over the duration of the EPI-BOLD scan, and used to train a predictive model to estimate head pose changes from the video data. Model performance was quantified by assessing the coefficient of determination (R). We evaluated the utility of our technique by assessing the relationship between video-based head pose changes during structural MRI and (i) vertex-wise cortical thickness and (ii) subcortical volume estimates.

Results: Video-based head pose estimates were significantly correlated with ground truth head pose changes estimated from EPI-BOLD imaging in a hold-out dataset. We observed a general brain-wide overall reduction in cortical thickness with increased head motion, with some isolated regions showing increased cortical thickness estimates with increased motion. Subcortical volumes were generally reduced in motion affected scans.

Conclusions: We trained a predictive model to estimate changes in head pose during structural MRI scans using in-scanner eye tracker video. The method is independent of individual image acquisition parameters and does not require markers to be to be fixed to the patient, suggesting it may be well suited to clinical imaging and research environments. Head pose changes estimated using our approach can be used as covariates for morphometric image analyses to improve the neurobiological validity of structural imaging studies of brain development and disease.
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http://dx.doi.org/10.1016/j.mri.2021.06.010DOI Listing
June 2021

Risk spillover networks in financial system based on information theory.

PLoS One 2021 18;16(6):e0252601. Epub 2021 Jun 18.

School of Economics, Wuhan Textile University, Wuhan, Hubei, China.

Since the financial system has illustrated an increasingly prominent characteristic of inextricable connections, information theory is gradually utilized to study the financial system. By collecting the daily data of industry index (2005-2020) and region index (2012-2020) listed in China as samples, this paper applies an innovative measure named partial mutual information on mixed embedding to generate directed networks. Based on the analysis of nonlinear relationships among sectors, this paper realizes the accurate construction of "time-varying" financial network from the perspective of risk spillover. The results are presented as follow: (1) interactions can be better understood through the nonlinear networks among distinct sectors, and sectors in the networks could be classified into different types according to their topological properties connected to risk spillover; (2) in the rising stage, information is transmitted rapidly in the network, so the risk is fast diffused and absorbed; (3) in the declining stage, the network topology is more complex and panic sentiments have long term impact leading to more connections; (4) The US market, Japan market and Hongkong market have significant affect on China's market. The results suggest that this nonlinear measure is an effective approach to develop financial networks and explore the mechanism of risk spillover.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0252601PLOS
June 2021

Euphatexols C - G, five new triterpenoids from the latex of .

J Asian Nat Prod Res 2021 Jun 18:1-10. Epub 2021 Jun 18.

The Laboratory of Effective Substances of Jiangxi Genuine Medicinal Materials, College of Life Sciences, Jiangxi Normal University, Nanchang 330022, China.

Five new triterpenoids named as euphatexols C - G (-) were isolated from the latex of . Their chemical structures were determined by extensive spectroscopic analysis, including IR, HRMS, 1 D and 2 D NMR data. Compounds showed moderate anti-inflammatory activity with IC values of 22.30, 48.04, 21.89, 38.15 and 41.15 μM, respectively.
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http://dx.doi.org/10.1080/10286020.2021.1935894DOI Listing
June 2021

Targeting E3 Ubiquitin-Ligase WWP1 Prevents Cardiac Hypertrophy Through Destabilizing DVL2 via Inhibition of K27-Linked Ubiquitination.

Circulation 2021 Jun 18. Epub 2021 Jun 18.

State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, China.

Without adequate treatment, pathological cardiac hypertrophy induced by sustained pressure overload eventually leads to HF (HF). WW domain- containing E3 ubiquitin protein ligase 1 (WWP1) is an important regulator of aging-related pathologies, including cancer and cardiovascular diseases. However, the role of WWP1 in pressure overload-induced cardiac remodeling and HF is yet to be determined. To examine the correlation of WWP1 with hypertrophy, we analyzed WWP1 expression in patients with HF and mice subjected to transverse aortic constriction (TAC) by Western blotting and immunohistochemical staining. TAC surgery was performed on WWP1 knockout (KO) mice to assess the role of WWP1 in cardiac hypertrophy, heart function was examined by echocardiography and related cellular and molecular markers were examined. Mass spectrometry and coimmunoprecipitation assays were conducted to identify the proteins that interacted with WWP1. Pulse-chase assay, ubiquitination assay, reporter gene assay and an mouse model via adeno-associated virus serotype 9 (AAV9) were used to explore the mechanisms by which WWP1 regulates cardiac remodeling. AAV9 carrying cTnT promoter driven small hairpin RNA targeting WWP1 (AAV9-cTnT-shWWP1) was administered to investigate its rescue role in TAC-induced cardiac dysfunction. The WWP1 level was significantly increased in the hypertrophic hearts from patients with HF and mice subjected to TAC. The results of echocardiography and histology demonstrated that WWP1 KO protected the heart from TAC-induced hypertrophy. There was a direct interaction between WWP1 and disheveled segment polarity protein 2 (DVL2). DVL2 was stabilized by WWP1 mediated K27-linked polyubiquitination. The role of WWP1 in pressure overload-induced cardiac hypertrophy was mediated by the DVL2/CaMKII/HDAC4/MEF2C signaling pathway. Therapeutic targeting WWP1 almost abolished TAC induced heart dysfunction, suggesting WWP1 as a potential target for treating cardiac hypertrophy and failure. We identified WWP1 as a key therapeutic target for pressure overload induced cardiac remodeling. We also found a novel mechanism regulated by WWP1. WWP1 promotes atypical K27-linked ubiquitin multichain assembly on DVL2 and exacerbates cardiac hypertrophy by the DVL2/CaMKII/HDAC4/MEF2C pathway.
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http://dx.doi.org/10.1161/CIRCULATIONAHA.121.054827DOI Listing
June 2021

Racial and Ethnic Disparities Persist in the Current Era of Pediatric Heart Transplantation.

J Card Fail 2021 Jun 14. Epub 2021 Jun 14.

Kaufman Center for Heart Failure, Department of Cardiology, Cleveland Clinic, Cleveland, Ohio.

Background: Older studies demonstrated that children in the U.S. from racial and ethnic minorities have inferior waitlist and post-heart transplant (HT) outcomes. Whether these disparities still exist in the contemporary era of increased ventricular assist device utilization remains unknown.

Methods: All children (age <18 years) in the SRTR database listed for HT from December 2011 to February 2019 were included and separated into 5 race/ethnicities: Caucasian, African American, Hispanic, Asian and Other. Differences in clinical characteristics and survival amongst children of different racial/ethnic groups were compared at listing and at HT.

Results: The waitlist cohort consisted of 2134 (52.2%) Caucasian, 840 (20.5%) African American, 808 (19.8%) Hispanic, 161 (3.9%) Asian, and 146 children of Other races (3.6%). At listing, Asian children mostly had cardiomyopathy (70.8%) while Caucasian children had congenital heart disease (58.7%). African American children were most likely to be listed Status 1A, have renal dysfunction and hypoalbuminemia at listing. African American and Hispanic children were most likely to be on Medicaid. On multivariable analysis, only African American children were at increased risk for waitlist mortality compared to Caucasian children (aHR = 1.25; p = 0.029). Post-HT, there were no disparities in early and mid-term graft survival among groups, however, African American children had increased number of rejection episodes compared to Caucasian and Hispanic children.

Conclusion: African American children continue to experience increased waitlist mortality and have increased rejection episodes post-HT. Studies exploring barriers to healthcare access and implicit bias as reasons for these disparities need to be explored.
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http://dx.doi.org/10.1016/j.cardfail.2021.05.027DOI Listing
June 2021

Transductive Relation-Propagation With Decoupling Training for Few-Shot Learning.

IEEE Trans Neural Netw Learn Syst 2021 Jun 17;PP. Epub 2021 Jun 17.

Few-shot learning, aiming to learn novel concepts from one or a few labeled examples, is an interesting and very challenging problem with many practical advantages. Existing few-shot methods usually utilize data of the same classes to train the feature embedding module and in a row, which is unable to learn adapting to new tasks. Besides, traditional few-shot models fail to take advantage of the valuable relations of the support-query pairs, leading to performance degradation. In this article, we propose a transductive relation-propagation graph neural network (GNN) with a decoupling training strategy (TRPN-D) to explicitly model and propagate such relations across support-query pairs, and empower the few-shot module the ability of transferring past knowledge to new tasks via the decoupling training. Our few-shot module, namely TRPN, treats the relation of each support-query pair as a graph node, named relational node, and resorts to the known relations between support samples, including both intraclass commonality and interclass uniqueness. Through relation propagation, the model could generate the discriminative relation embeddings for support-query pairs. To the best of our knowledge, this is the first work that decouples the training of the embedding network and the few-shot graph module with different tasks, which might offer a new way to solve the few-shot learning problem. Extensive experiments conducted on several benchmark datasets demonstrate that our method can significantly outperform a variety of state-of-the-art few-shot learning methods.
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http://dx.doi.org/10.1109/TNNLS.2021.3082928DOI Listing
June 2021

Photocoagulation-associated spontaneous release of epiretinal membrane secondary to retinal vascular tumor: case series of 8 cases.

Lasers Med Sci 2021 Jun 17. Epub 2021 Jun 17.

Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, 200031, China.

To evaluate the secondary epiretinal membrane (ERM) response after photocoagulation in retinal vascular tumor. This retrospective interventional case series included 8 patients (8 eyes) who were diagnosed with retinal vascular tumor and secondary ERM. All eyes were treated with photocoagulation and underwent comprehensive ophthalmologic examinations at baseline and at each follow-up. Of the 8 eyes with retinal vascular tumor and associated ERM, 4 eyes (50%) were von Hippel and 4 eyes (50%) were vasoproliferative tumor of the retina. The mean follow-up time was 12.63 ± 14.64 (range, 4-51) months. The BCVA in the eyes at baseline was 1.16 ± 1.10 logMAR (range, HM to 20/40). ERM located in the macular region in 100% of the eyes and led to CME with a mean central foveal thickness of 497.6 ± 147.7 μm (range, 294-736 μm) at presentation. After photocoagulation, the ERM spontaneously peeled in 7 of 8 eyes (87.5%), among which one case required surgical treatment due to complicating tractional retinal detachment. After ERM peeling without complications, 6 eyes recovered normal macular structure, with an improved BCVA in 5 eyes and a stable BCVA in 1 eye. Laser photocoagulation is necessary and effective treatment for retinal vascular tumor. After laser photocoagulation, retinal vascular tumor-related ERM spontaneously released in 75% of the cases, without complication and surgical intervention.
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http://dx.doi.org/10.1007/s10103-021-03351-9DOI Listing
June 2021

Carbon-Based MOF Derivatives: Emerging Efficient Electromagnetic Wave Absorption Agents.

Nanomicro Lett 2021 Jun 6;13(1):135. Epub 2021 Jun 6.

School of Materials Science and Engineering, Shandong University, Jinan, 250061, People's Republic of China.

To tackle the aggravating electromagnetic wave (EMW) pollution issues, high-efficiency EMW absorption materials are urgently explored. Metal-organic framework (MOF) derivatives have been intensively investigated for EMW absorption due to the distinctive components and structures, which is expected to satisfy diverse application requirements. The extensive developments on MOF derivatives demonstrate its significantly important role in this research area. Particularly, MOF derivatives deliver huge performance superiorities in light weight, broad bandwidth, and robust loss capacity, which are attributed to the outstanding impedance matching, multiple attenuation mechanisms, and destructive interference effect. Herein, we summarized the relevant theories and evaluation methods, and categorized the state-of-the-art research progresses on MOF derivatives in EMW absorption field. In spite of lots of challenges to face, MOF derivatives have illuminated infinite potentials for further development as EMW absorption materials.
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http://dx.doi.org/10.1007/s40820-021-00658-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8180543PMC
June 2021

Non-Magnetic Bimetallic MOF-Derived Porous Carbon-Wrapped TiO/ZrTiO Composites for Efficient Electromagnetic Wave Absorption.

Nanomicro Lett 2021 Feb 17;13(1):75. Epub 2021 Feb 17.

School of Materials Science and Engineering, Shandong University, Jinan, 250061, People's Republic of China.

Highlights: Non-magnetic bimetallic MOF-derived porous carbon-wrapped TiO/ZrTiO composites are firstly used for efficient electromagnetic wave absorption. The electromagnetic wave absorption mechanisms including enhanced interfacial polarization and essential conductivity are intensively discussed. Modern communication technologies put forward higher requirements for electromagnetic wave (EMW) absorption materials. Metal-organic framework (MOF) derivatives have been widely concerned with its diverse advantages. To break the mindset of magnetic-derivative design, and make up the shortage of monometallic non-magnetic derivatives, we first try non-magnetic bimetallic MOFs derivatives to achieve efficient EMW absorption. The porous carbon-wrapped TiO/ZrTiO composites derived from PCN-415 (TiZr-MOFs) are qualified with a minimum reflection loss of - 67.8 dB (2.16 mm, 13.0 GHz), and a maximum effective absorption bandwidth of 5.9 GHz (2.70 mm). Through in-depth discussions, the synergy of enhanced interfacial polarization and other attenuation mechanisms in the composites is revealed. Therefore, this work confirms the huge potentials of non-magnetic bimetallic MOFs derivatives in EMW absorption applications.
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http://dx.doi.org/10.1007/s40820-021-00606-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187513PMC
February 2021