Publications by authors named "Wei Liu"

11,050 Publications

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Measuring spatial accessibility to refuge green space after earthquakes: A case study of Nanjing, China.

PLoS One 2022 28;17(6):e0270035. Epub 2022 Jun 28.

College of Landscape Architecture, Nanjing Forestry University, Nanjing, PR China.

The construction of refuge spaces in rapidly urbanizing historic cities is a challenging task owing to their complex urban form, unique urban fabric, and historic preservation requirements. Refuge green space (RGS) is a green space that can serve as an emergency shelter in cities, providing a flexible means to increase the emergency shelter capacity for rapidly urbanized historic cities. After major earthquakes, spatial accessibility to GRSs is a critical planning strategy for disaster prevention and emergency response in historic cities. To match the RGS planning with the emergency service demand, we must examine the spatial disparity in access to existing RGSs. In this study, the urban area of Nanjing was selected as the target region to analyze the spatial disparity in access to RGSs using the Gaussian two-step floating catchment area method at four evacuation times (10, 20, 30, and 60 min). The results showed that the spatial accessibility exhibited clustering characteristics, where high-accessibility spaces were mainly distributed in the northern and southern regions of Nanjing. The increase in the evacuation time improved accessibility to RGSs, but the existing RGSs still could not sufficiently satisfy the emergency shelter needs of citizens. Based on the bivariate local Moran's I analysis of the RGS accessibility and population density, the spatial mismatch regions were dominant in the center of the urban area. These findings not only are expected to assist emergency planners by improving their strategic plans for emergency shelter investment in Nanjing and their ability to respond to catastrophic earthquakes, but also provide a strong reference for the construction of a safe environment in other rapidly developing historic cities that face earthquake threats.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0270035PLOS
June 2022

Effect of prenatal and postnatal exposure to home renovation on the risk of common cold in preschool children.

Indoor Air 2022 Jun;32(6):e13063

Department of Medical Sciences, Uppsala University, Uppsala, Sweden.

Common cold is usually considered to be associated with outdoor climate, but the evidence linking with indoor environmental factors is lacking. The role of indoor renovations during which critical timing window on childhood common cold remains unclear. Therefore, we investigated the effect of exposure to new furniture and/or redecoration during prenatal and postnatal periods on the occurrence and duration of common cold in preschool children. We conducted a retrospective cohort study of 39 782 children aged 3-6 years in seven cities of China. The occurrence and duration of common cold in children, and their lifetime exposures to indoor new furniture and redecoration (including pregnancy, the first year of life, and after one year old) were assessed using a questionnaire administered by the parents. Associations between high frequency (>5 colds) and long duration (≥2 weeks per cold) of common cold during past 12 months and exposure to indoor new furniture/redecoration were examined by logistic regression models in terms of odds ratio (OR) and 95% confidence interval (CI). We found that the prevalence of high frequency and long duration of common cold in preschool children in China were, respectively, 9.2% and 11.9%. Frequent common cold was significantly associated with exposure to indoor new furniture/redecoration during pregnancy, first year, and after 1 year old, respectively, with the ORs (95% CI) = 1.25 (1.12-1.39), 1.11 (1.00-1.25), and 1.09 (1.01-1.18). Furthermore, childhood long duration per cold was associated with exposure to indoor new furniture/redecoration during pregnancy with OR (95% CI) of 1.14 (1.03-1.25) but not with postnatal exposure. We identified that prenatal exposure to home renovation was more critical than postnatal exposure for an increased risk of high frequency and long duration of common cold. Sensitivity analysis showed that the association between prenatal exposure to indoor renovations and the risk of childhood common cold was consistent and robust, and the associations were modified by some personal and indoor environmental factors. Our findings indicated that prenatal and postnatal exposure to home renovation played an important role in the risk of childhood common cold, supporting the hypothesis of "fetal origin of childhood infection."
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http://dx.doi.org/10.1111/ina.13063DOI Listing
June 2022

Polysaccharides from Cordyceps militaris prevent obesity in association with modulating gut microbiota and metabolites in high-fat diet-fed mice.

Food Res Int 2022 Jul 1;157:111197. Epub 2022 Apr 1.

Department of Food Science and Engineering, Institute of Food Safety and Nutrition, College of Science & Engineering, Jinan University, Guangzhou 510632, China. Electronic address:

Improved gut microbes and nutritious metabolites have been considered as the mediators of health benefits from indigestible polysaccharides, but their role in the anti-obesity effect of polysaccharides from Cordyceps militaris (CMP) remains elusive. This study aims to explore the potential mediators of the anti-obesity effects of CMP in high-fat diet (HFD)-fed mice using 16S rRNA sequencing and untargeted metabolomics analysis. The results showed that CMP supplementation in HFD-fed mice reduced body weight, fat accumulation, pro-inflammatory cytokine levels, and impaired glucose tolerance as well as gut barrier. Moreover, the CMP reversed the HFD-induced gut microbiota dysbiosis, as indicated by the elevated population of Alloprevotella, Parabacteroides, Butyricimonas, and Alistipes; and decreased population of Negativebacillus, in addition to altered levels of metabolites, such as brassicasterol and 4'-O-methylkanzonol W. Notably, CMP prevented obesity in association with the altered gut microbes and metabolites. These findings suggest that CMP may serve as a potential prebiotic agent to modulate specific gut microbes and related metabolites, which play a critical role in its preventing obesity-related diseases.
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http://dx.doi.org/10.1016/j.foodres.2022.111197DOI Listing
July 2022

Recurrent spontaneous pneumoperitoneum secondary to intestinal dilatation caused by allied disorders of Hirschsprung's disease: a case report.

BMC Gastroenterol 2022 Jun 27;22(1):316. Epub 2022 Jun 27.

Division of General Internal Medicine, Department of Primary Care & Family Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, State Key Laboratory of Complex Severe and Rare Diseases (Peking Union Medical College Hospital), Beijing, 100730, China.

Background: Allied disorders of Hirschsprung's disease (ADHD) mainly present with bowel obstruction, intestinal dilatation, and chronic constipation, while recurrent spontaneous pneumoperitoneum was rarely reported. We aimed to report a case of recurrent spontaneous pneumoperitoneum caused by ADHD.

Case Presentation: A 59-year-old female patient presented with progressive and severe constipation in the past 30 years. She suffered from abdominal discomfort, which was described as 'gurgling' during the last three years. Radiography showed free-air and intestinal dilatation, without any other diseases, and she was identified with recurrent spontaneous pneumoperitoneum. Gastrointestinal transit test indicated gastrointestinal motility disorder, and anorectal manometry confirmed the presence of rectal anus-suppressing reflex. Subtotal colectomy was performed to relieve apparent constipation, and the postoperative pathological examination of the colon demonstrated proliferation of nerve fibers and hyperplasia of myenteric plexuses, as well as a relatively scarcity of ganglion cells in the myenteric plexus. Based on the presentations and the postoperative pathology, she was diagnosed with ADHD. The recurrent spontaneous pneumoperitoneum was regarded as the gas escape from dilated intestines, which was in high pressure. All the symptoms and her mental state were improved after the treatment with gastrointestinal decompression and enteral nutrition. However, during follow-up visits, she had intestinal infection, and suffered from severe diarrhea and water-electrolyte imbalance, and the patient eventually died at 17 months after the diagnosis.

Conclusion: ADHD could be a rare cause of recurrent spontaneous pneumoperitoneum, and are mainly undiagnosed or misdiagnosed. A full-thickness biopsy of the gastrointestinal tract (especially the small intestine and sigmoid colon) and differential diagnosis are recommended for the definitive diagnosis. While the ADHD have shown a poor prognosis, timely and long-term treatment with intestinal decompression and nutritional therapy could help relieve symptoms and provide a better quality of life for such patients.
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http://dx.doi.org/10.1186/s12876-022-02376-wDOI Listing
June 2022

Quasi-solid-state Zn-air batteries with an atomically dispersed cobalt electrocatalyst and organohydrogel electrolyte.

Nat Commun 2022 Jun 27;13(1):3689. Epub 2022 Jun 27.

State Key Laboratory of Powder Metallurgy, Central South University, Changsha, PR China.

Quasi-solid-state Zn-air batteries are usually limited to relatively low-rate ability (<10 mA cm), which is caused in part by sluggish oxygen electrocatalysis and unstable electrochemical interfaces. Here we present a high-rate and robust quasi-solid-state Zn-air battery enabled by atomically dispersed cobalt sites anchored on wrinkled nitrogen doped graphene as the air cathode and a polyacrylamide organohydrogel electrolyte with its hydrogen-bond network modified by the addition of dimethyl sulfoxide. This design enables a cycling current density of 100 mA cm over 50 h at 25 °C. A low-temperature cycling stability of over 300 h (at 0.5 mA cm) with over 90% capacity retention at -60 °C and a broad temperature adaptability (-60 to 60 °C) are also demonstrated.
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http://dx.doi.org/10.1038/s41467-022-31383-4DOI Listing
June 2022

Correction to: Transcriptome analysis of skin color variation during and after overwintering of Malaysian red tilapia.

Fish Physiol Biochem 2022 Jun 27. Epub 2022 Jun 27.

Wuxi Fisheries College, Nanjing Agricultural University, Wuxi, Jiangsu, China.

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http://dx.doi.org/10.1007/s10695-022-01092-2DOI Listing
June 2022

Editorial: Barriers to Promoting Physical Activity in Low- and Middle-Income Countries: Alignment With the Sustainable Development Goals.

Authors:
Wei Liu

Front Public Health 2022 9;10:943428. Epub 2022 Jun 9.

Key Research Base of Humanities and Social Sciences in Colleges and Universities in Anhui - Quality Education Research Center for College Students of Anhui Xinhua University, Hefei, China.

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http://dx.doi.org/10.3389/fpubh.2022.943428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221515PMC
June 2022

The Roles of Drug Metabolism-Related ADH1B in Immune Regulation and Therapeutic Response of Ovarian Cancer.

Front Cell Dev Biol 2022 9;10:877254. Epub 2022 Jun 9.

Department of Pathology, Xiangya Hospital, Central South University, Changsha, China.

The different pharmacological effects of drugs in different people can be explained by the polymorphisms of drug metabolism-related genes. Emerging studies have realized the importance of drug metabolism-related genes in the treatment and prognosis of cancers, including ovarian cancer (OV). In this study, using comprehensive bioinformatics and western blot, we identified that the drug metabolism-related gene, ADH1B, was significantly down-regulated in OV cells and tissues. The patients with a high level of ADH1B presented a good prognosis. We also found a negative correlation between ADH1B expression and the activity of chemotherapeutic agents, such as cyclophosphamide. In addition, positive correlations were observed between ADH1B expression and multiple immune checkpoints, including LAG3 and HAVCR2. The immune infiltration analysis further indicated that aberrantly expressed ADH1B might have important roles in regulating the infiltration of macrophages and neutrophils in OV tissues. Then, the co-expression analysis was conducted and the top three enriched KEGG pathways were spliceosome, RNA transport, and DNA replication. In conclusion, the drug metabolism-related gene ADH1B and its interactive network play an essential role in the immune regulation and therapeutic response and maybe identified as promising therapeutic targets for OV patients.
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http://dx.doi.org/10.3389/fcell.2022.877254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218672PMC
June 2022

Metabolic engineering of Yarrowia lipolytica for scutellarin production.

Synth Syst Biotechnol 2022 Sep 6;7(3):958-964. Epub 2022 Jun 6.

Key Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.

Scutellarin related drugs have superior therapeutic effects on cerebrovascular and cardiovascular diseases. Here, an optimal biosynthetic pathway for scutellarin was constructed in platform due to its excellent metabolic potential. By integrating multi-copies of core genes from different species, the production of scutellarin was increased from 15.11 mg/L to 94.79 mg/L and the ratio of scutellarin to the main by-product was improved about 110-fold in flask condition. Finally, the production of scutellarin was improved 23-fold and reached to 346 mg/L in fed-batch bioreactor, which was the highest reported titer for production of scutellarin in microbes. Our results represent a solid basis for further production of natural products on unconventional yeasts and have a potential of industrial implementation.
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http://dx.doi.org/10.1016/j.synbio.2022.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184295PMC
September 2022

Relationship of DNA aneuploidy with distinctive features of oral potentially malignant disorders: A cytological analysis of 748 cases.

J Dent Sci 2022 Apr 26;17(2):1035-1038. Epub 2021 Oct 26.

College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai, China.

Our previous study reported that clinical features, including the lateral/ventral tongue and non-homogeneous lesions, were associated with increased risk of malignant changes in cytological samples from oral potentially malignant disorders (OPMDs). This cross-sectional study aimed to evaluate the frequency and risk of DNA aneuploidy in the series of 748 patients with OPMD. The cut-off value of aneuploidy was defined as DNA index ≥3.5. We found that the frequency of DNA aneuploidy was higher in OPMD patients >60 years old, and in those with lateral/ventral tongue sites, non-homogeneous lesions, and high-grade dysplasia, than in control group ( < 0.01). Consistently, the risk of aneuploidy occurrence was higher in patients >60 years old (1.69-fold;  = 0.022), in those with lateral/ventral tongue sites (2.35-fold;  < 0.001), and in those with high-grade dysplasia (3.19-fold;  < 0.001). Collectively, increased frequency and risk of DNA aneuploidy occurred in OPMD patients aged over 60 years with high-grade dysplasia located at the lateral/ventral tongue. These patients should be required to intensive management and follow-up.
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http://dx.doi.org/10.1016/j.jds.2021.10.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9201530PMC
April 2022

Dancing in Shackles: The Double-Edged Sword Effect of Felt Accountability on Work Outcomes and Individual Wellbeing.

Front Psychol 2022 10;13:904946. Epub 2022 Jun 10.

Department of Organization and Human Resource Management, Business School, Central University of Finance and Economics, Beijing, China.

Accountability is a core element for groups and societies to operate efficiently. However, there have been confusing findings in previous studies on felt accountability, and few efforts have been made to clarify its complicated role. Drawing on self-determination theory, we developed an integrative model to examine the double-edged sword effect of felt accountability on work outcomes and individual wellbeing. We utilized a three-wave sample of 294 employees to test our hypotheses. The findings supported our hypotheses. Specifically, felt accountability is positively related to both task performance and emotional exhaustion, and obsessive passion mediates the positive relationship between felt accountability and task performance, while work overload mediates the positive relationship between felt accountability and emotional exhaustion. This study integrates the positive and dark sides of felt accountability, provides new insights into its mechanism and expands the application of self-determination theory.
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http://dx.doi.org/10.3389/fpsyg.2022.904946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226577PMC
June 2022

Genomic and Biocontrol Potential of the Crude Lipopeptide by HD-087 Against .

Front Microbiol 2022 9;13:888645. Epub 2022 Jun 9.

Engineering Research Center of Agricultural Microbiology Technology, Ministry of Education, Heilongjiang University, Harbin, China.

Rice blast caused by is one of the most destructive plant diseases. The secondary metabolites of have potential as biological control agents against . However, no commercial secondary antimicrobial products of have been found by gene prediction, and, particularly relevant for this study, a biocontrol agent obtained from has yet to be found. In this research, genomic analysis was used to predict the secondary metabolites of , and the ability to develop biocontrol pharmaceuticals rapidly was demonstrated. The complete genome of the HD-087 strain was sequenced and revealed a number of key functional gene clusters that contribute to the biosynthesis of active secondary metabolites. The crude extract of lipopeptides (CEL) predicted by NRPS gene clusters was extracted from the fermentation liquid of HD-087 by acid precipitation followed by methanol extraction, and surfactins, iturins, and fengycins were identified by liquid chromatography-mass spectrometry (LC-MS). , the CEL of this strain inhibited spore germination and appressorial formation of by destroying membrane integrity and through the leakage of cellular components. , this CEL reduced the disease index of rice blast by approximately 76.9% on detached leaves, whereas its control effect on leaf blast during pot experiments was approximately 60%. Thus, the CEL appears to be a highly suitable alternative to synthetic chemical fungicides for controlling .
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http://dx.doi.org/10.3389/fmicb.2022.888645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218715PMC
June 2022

Alleviates the Production of Inflammatory Cytokines and MUC5AC in Rats with Chronic Obstructive Pulmonary Disease.

Evid Based Complement Alternat Med 2022 16;2022:2135487. Epub 2022 Jun 16.

Geriatric Respiratory Department, Henan Electric Power Hospital, Zhengzhou, China.

Background: (RC), a perennial evergreen herb which belongs to Kunth (Liliaceae), can be used for clearing the lungs and relieving cough, reducing phlegm and anti-inflammatory effects. Moreover, chronic obstructive pulmonary disease (COPD) is characterized by airway and lung inflammation and increased secretion of airway mucus. Therefore, RC has the potential to treat COPD.

Methods: NR8383 cells were cultured and treated with various concentrations of RC (100 mg/mL, 10 mg/mL, 1 mg/mL, 100 g/mL, 10 g/mL, 1 g/mL, 100 ng/mL, and 10 ng/mL). Cell viability and levels of interleukin (IL)-1 cyclooxygenase-2 (COX-2), and prostaglandin E2 (PGE2) in the cell culture supernatant or rat serum were analyzed using CCK-8 and enzyme-linked immunosorbent assay (ELISA), respectively. Sprague Dawley rats were assigned to mock, COPD model, RC (0.67 g/kg, 1.35 g/kg, and 2.7 g/kg), and ambroxol (5.4 mg/kg) groups. Western blot and quantitative polymerase chain reaction (qPCR) analyses were used to evaluate the protein and mRNA expression levels of mucin 5AC (MUC5AC) and Toll-like receptor 4 (TLR4).

Results: The results showed that (RC) extract (RCE) inhibited the proliferation of NR8383 cells and suppressed the production of IL-1, PGE2, and COX-2 in NR8383 cells. Moreover, RCE decreased the levels of IL-1 PGE2, and COX-2 in the serum of rats with COPD and alleviated the expression of TLR4 and MUC5AC induced by COPD in rat lung tissue.

Conclusion: RCE alleviated COPD by inhibiting the expression of COPD-induced inflammatory cytokines and MUC5AC in rats.
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http://dx.doi.org/10.1155/2022/2135487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9225912PMC
June 2022

The Xiangya equation could not replace the Asian modified CKD-EPI equation in estimating glomerular filtration rate in Chinese patients with chronic kidney disease.

Int Urol Nephrol 2022 Jun 26. Epub 2022 Jun 26.

Department of Nuclear Medicine, The Third Hospital of Hebei Medical University, No.139, ZiQiang Road, Shijiazhuang, 050051, Hebei Province, People's Republic of China.

Background: To evaluate the clinical practicability of the Xiangya equation in estimating glomerular filtration rate (GFR) and compare with the Asian modified Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) equation, assessing whether the Xiangya equation could replace the Asian modified CKD-EPI equation as the preferred method for predicting GFR in the Chinese CKD patients in an external validation study.

Methods: The GFR was determined simultaneously by two methods: (a) the Asian modified CKD-EPI equation (GFR); (b) the Xiangya equation (GFR); diagnostic performance of the two models was compared by the regression analysis, the Bland-Altman plot, bias, precision and P under the background of Tc-diethylenetriaminepentaacetic acid (Tc-DTPA) dual plasma sample clearance method as reference method for GFR measurement (mGFR).

Results: A total of 158 Chinese CKD patients were included in our external study. The GFR was highly related with mGFR, with the correlation coefficient of 0.92. The regression equation was GFR = 0.55*mGFR + 28.25, where the regression coefficient was far away from one and the intercept was wide. Compared with the Asian modified CKD-EPI equation, the performance of the Xiangya equation demonstrated a poorer bias (9.5 vs - 3.3 ml/min/1.73 m, P < 0.001), an inferior precision (23.9 vs 13.0 ml/min/1.73 m, P < 0.001), a lower P (51.3% vs 73.4%, P < 0.001) and a wider 95% limit of agreement in Bland-Altman analysis (65.0 vs 44.9 ml/min/1.73 m).

Conclusion: Due to relatively inferior performance, the Xiangya equation could not replace the Asian modified CKD-EPI equation in estimating GFR in Chinese patients with chronic kidney disease in our external cohort.
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http://dx.doi.org/10.1007/s11255-022-03248-8DOI Listing
June 2022

Health-related quality of life among adults with haemophilia in China: A comparison with age-matched general population.

Haemophilia 2022 Jun 25. Epub 2022 Jun 25.

State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin Key Laboratory of Gene Therapy for Blood Diseases, CAMS Key Laboratory of Gene Therapy for Blood Diseases, Tianjin, China.

Introduction: Evaluating health-related quality of life (HRQoL) is vital for informing the improvement of the overall health of people with haemophilia (PwH). While there is lacking such data in China and comparisons with the general population.

Aim: To evaluate the HRQoL and its associated factors among adults with haemophilia, and compare it with a sample of the general population in China.

Methods: PwH were recruited in this study using telephone-based interviews. Demographic and clinical characteristics were first collected. HRQoL was then evaluated using the self-reported Short Form 6-dimensions version 2 (SF-6Dv2) instrument. An age and gender-matched sample of the general population in China was also included as the comparator group. Linear regression was used to assess the association between the SF-6Dv2 utility value and the demographic and clinical variables of the patients.

Results: This study included 206 PwH (mean [SD] age: 41.36 [14.48] years) and 206 respondents from the general population. PwH reported worse levels in physical functioning, role limitation, social functioning, and mental health dimensions on SF-6Dv2 than the general respondents. The mean (SD) utility of patients was .650 (.251), which was significantly lower than the general respondents (.786 [.183], P < .001). Being a student, having a higher monthly income, absence of comorbidities, having no target joints and requiring no treatment are independent predictors of a higher HRQoL for PwH.

Conclusion: This study provides the first practical evidence of a significantly lower level of HRQoL in PwH than in the general population in China.
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http://dx.doi.org/10.1111/hae.14615DOI Listing
June 2022

Effectiveness and Safety of Sofosbuvir/Velpatasvir/Voxilaprevir as a Hepatitis C Virus Infection Salvage Therapy in the Real World: A Systematic Review and Meta-analysis.

Infect Dis Ther 2022 Jun 24. Epub 2022 Jun 24.

Department of Pharmacy, Beijing Youan Hospital, Capital Medical University, No. 8 Xitoutiao, Youanmenwai, Fengtai District, Beijing, China.

Introduction: Sofosbuvir/Velpatasvir/Voxilaprevir (SOF/VEL/VOX) is the first direct-acting antiviral (DAA) therapy approved for patients who have previously failed a DAA-containing regimen including NS5A inhibitors. In clinical trials, SOF/VEL/VOX was associated with high rates of sustained virologic response at post-treatment week 12 (SVR12) and was well tolerated. However, the effectiveness and safety of SOF/VEL/VOX in the real world remained uncertain. We aimed to perform a systematic review and meta-analysis to assess the real world effectiveness and safety of SOF/VEL/VOX.

Methods: We systematically searched the PubMed, Embase, Cochrane Library, Web of Science, and ClinicalTrials.gov databases for relevant real world studies published before January 28, 2022. Patients with previous treatment failure who received SOF/VEL/VOX were included. The primary outcome was the percentage of patients achieving SVR12. Secondary outcome included adverse events (AEs) during treatment.

Results: Fifteen studies with a total of 1796 HCV-infected patients with previous treatment failure were included. SVR12 rates were 93% (95% CI 91-95) in the ITT populations (n = 1517, 11 cohorts) and 96% (95% CI 95-97) in the PP populations (n = 1187, 10 cohorts). SVR12 rates were significantly higher in non-GT3-infected patients (OR = 2.29, 95% CI 1.23-4.27, P = 0.009) and non-cirrhotic patients (OR = 2.22, 95% CI 1.07-4.60, P = 0.03) than in GT3-infected patients and cirrhotic patients. Furthermore, the SVR12 rates of previous treatment of SOF/VEL were significantly lower than those of other regimens in both ITT and PP populations (P ≤ 0.001). Adverse events (AEs) were reported in 30% (228/760) of patients. Serious AEs (SAEs) were reported in 3.82% (29/760) of patients. The most frequently reported AEs were headache, asthenia, nausea, fatigue, and diarrhea, which were mostly mild in severity. AE-related treatment discontinuations were reported in 0.66% (5/760) of patients.

Conclusions: Consistent with clinical trials, the real world evidence indicates that SOF/VEL/VOX is a well-tolerated and highly effective salvage therapy for HCV-infected patients with previous treatment failure. However, there may still be a risk of treatment failure for patients with GT3 infection, cirrhosis, or SOF/VEL treatment failure. The protocol of this study was registered at PROSPERO, registration no. CRD 42022306828.
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http://dx.doi.org/10.1007/s40121-022-00666-0DOI Listing
June 2022

Interfacially Locked Metal Aerogel Inside Porous Polymer Composite for Sensitive and Durable Flexible Piezoresistive Sensors.

Adv Sci (Weinh) 2022 Jun 24:e2201912. Epub 2022 Jun 24.

The Key Laboratory of Low-Carbon Chemistry & Energy Conservation of Guangdong Province, Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, State Key Laboratory of Optoelectronic Materials and Technologies, School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou, 510006, P. R. China.

Flexible pressure sensors play significant roles in wearable devices, electronic skins, and human-machine interface (HMI). However, it remains challenging to develop flexible piezoresistive sensors with outstanding comprehensive performances, especially with excellent long-term durability. Herein, a facile "interfacial locking strategy" has been developed to fabricate metal aerogel-based pressure sensors with excellent sensitivity and prominent stability. The strategy broke the bottleneck of the intrinsically poor mechanical properties of metal aerogels by grafting them on highly elastic melamine sponge with the help of a thin polydimethylsiloxane (PDMS) layer as the interface-reinforcing media. The hierarchically porous conductive structure of the ensemble offered the as-prepared flexible piezoresistive sensor with a sensitivity as high as 12 kPa , a response time as fast as 85 ms, and a prominent durability over 23 000 compression cycles. The excellent comprehensive performance enables the successful application of the flexible piezoresistive sensor as two-dimensional (2D) array device as well as three-dimensional (3D) force-detecting device for real-time monitoring of HMI activities.
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http://dx.doi.org/10.1002/advs.202201912DOI Listing
June 2022

Renal Protective Effects of Melatonin in Animal Models of Diabetes Mellitus-Related Kidney Damage: A Systematic Review and Meta-Analysis.

J Diabetes Res 2022 14;2022:3770417. Epub 2022 Jun 14.

Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100700, China.

Diabetic nephropathy (DN)-chronic kidney damage caused by hyperglycemia-eventually develops into end-stage renal disease (ESRD). Melatonin is a powerful antioxidant that has a wide range of biological activities. Potentially helpful effects of melatonin on diabetic kidney disease have been found in several studies. However, its protective mechanisms are not clear and remain to be explored. In this review (CRD42021285429), we conducted a meta-analysis to estimate the effects and relevant mechanisms of melatonin for diminishing renal injuries in diabetes mellitus models. The Cochrane Library, PubMed, and EMBASE databases up to September 2021 were used. Random- or fixed-effects models were used for calculating the standardized mean difference (SMD) or 90% confidence interval (CI). The risk of bias was estimated using the SYRCLE's RoB tool. Statistical analysis was conducted with RevMan. A total of 15 studies including 224 animals were included in the analysis. The experimental group showed a remarkable decrease in serum creatinine ( = 0.002), blood urea nitrogen ( = 0.02), and urinary albumin excretion rate (UAER) ( < 0.00001) compared with the control group, while the oxidative stress index improved. The experimental group also showed a remarkable increase in superoxide dismutase ( = 0.21), glutathione ( < 0.0001), and catalase ( = 0.04) and a remarkable decrease in MDA ( < 0.00001) content compared with the control group. We concluded that melatonin plays a role in renal protection in diabetic animals by inhibiting oxidative stress. Moreover, it should be noted that fasting blood glucose was reduced in the experimental group compared with the control group. The kidney and body weights of the animals were not decreased in the diabetic animal model compared with the control group.
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http://dx.doi.org/10.1155/2022/3770417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213184PMC
June 2022

Characterization of Chronic Hepatitis E Virus Infection in Immunocompetent Rabbits.

Viruses 2022 Jun 9;14(6). Epub 2022 Jun 9.

Division of HIV/AIDS and Sex-Transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing 102629, China.

Chronic hepatitis E virus (HEV) infection is frequently reported in immunocompromised patients, but has also been increasingly reported in non-immunocompromised individuals. We characterized the course of chronic HEV infection in immunocompetent rabbits. In two independent experiments, 40 specific-pathogen-free rabbits were infected with a rabbit HEV genotype 3 strain in serial diluted titers (10 to 10 copies/mL). Serum and fecal samples were collected weekly and were tested for HEV RNA, antigen, anti-HEV and liver enzymes. Rabbits that spontaneously cleared the infection before 10 weeks post-inoculation (wpi) were kept to the end of the study as recovery control. Liver tissues were collected from HEV-infected rabbits at 5, 10 and 26 wpi for histopathological analysis. Nineteen rabbits (47.5%) developed chronic HEV infection with persistent viraemia and fecal HEV shedding for >6 months. Seroconversion to anti-HEV was observed in 84.2% (16/19) of the chronically infected rabbits. Serum levels of aminotransferase were persistently elevated in most of the rabbits. Characterizations of chronic HEV infection in immunocompetent settings could be recapitulated in rabbits, which can serve as a valuable tool for future studies on pathogenesis.
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http://dx.doi.org/10.3390/v14061252DOI Listing
June 2022

Optimization of PBFT Algorithm Based on QoS-Aware Trust Service Evaluation.

Sensors (Basel) 2022 Jun 17;22(12). Epub 2022 Jun 17.

Department of Software Engineering, Wenchang Satellite Launch Center, Wenchang 571300, China.

In service-transaction scenarios, blockchain technology is widely used as an effective tool for establishing trust between service providers and consumers. The consensus algorithm is the core technology of blockchain. However, existing consensus algorithms, such as the practical Byzantine fault tolerance (PBFT) algorithm, still suffer from high resource consumption and latency. To solve this problem, in this study, we propose an improved PBFT blockchain consensus algorithm based on quality of service (QoS)-aware trust service evaluation for secure and efficient service transactions. The proposed algorithm, called the QoS-aware trust practical Byzantine fault tolerance (QTPBFT) algorithm, efficiently achieves consensus, significantly reduces resource consumption, and enhances consensus efficiency. QTPBFT incorporates a QoS-aware trust service global evaluation mechanism that implements service reliability ranking by conducting a dynamic evaluation according to the real-time performance of the services. To reduce the traffic of the blockchain, it uses a mechanism that selects nodes with higher values to form a consensus group that votes for consensus according to the global evaluation result of the trust service. A practical protocol is also constructed for the proposed algorithm. The results of extensive simulations and comparison with other schemes verify the efficacy and efficiency of the proposed scheme.
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http://dx.doi.org/10.3390/s22124590DOI Listing
June 2022

Heparin Protects Severe Acute Pancreatitis by Inhibiting HMGB-1 Active Secretion from Macrophages.

Polymers (Basel) 2022 Jun 17;14(12). Epub 2022 Jun 17.

Department of Critical Care Medicine, Zhongda Hospital, Southeast University, Nanjing 210009, China.

Heparin has shown benefits in severe acute pancreatitis (SAP) therapy, but the underlying mechanisms were unknown. Extracellular high-mobility group protein-1 (HMGB-1) has been regarded as a central mediator contributing to inflammation exacerbation and disease aggravation. We hypothesized heparin attenuated the disease by targeting HMGB-1-related pathways. In the present study, the possible therapeutic roles of heparin and its non-anticoagulant derivatives, 6-O-desulfulted heparin and N-acylated-heparin, were determined on mouse models induced by "Two-Hit" of L-arginine. The compounds exhibited potent efficiency by substantially decreasing the pancreatic necrosis, macrophage infiltration, and serum inflammatory cytokine (IL-6 and TNF-α) concentration. Moreover, they greatly reduced the rapidly increasing extracellular HMGB-1 levels in the L-arginine injured pancreases. As a result, multiple organ failure and mortality of the mice were inhibited. Furthermore, the drugs were incubated with the RAW264.7 cells activated with damaged pancreatic tissue of SAP mice in vitro. They were found to inhibit HMGB-1 transfer from the nucleus to the plasma, a critical step during HMGB-1 active secretion from macrophages. The results were carefully re-examined with a caerulein and LPS induced mouse model, and similar results were found. The paper demonstrated heparin alleviated SAP independent of the anti-coagulant functions. Therefore, non-anticoagulant heparin derivatives might become promising approaches to treat patients suffering from SAP.
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http://dx.doi.org/10.3390/polym14122470DOI Listing
June 2022

Poling-Free Hydroxyapatite/Polylactide Nanogenerator with Improved Piezoelectricity for Energy Harvesting.

Micromachines (Basel) 2022 May 31;13(6). Epub 2022 May 31.

State Key Laboratory of Mechanics and Control of Mechanical Structures, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China.

Polylactide-based piezoelectric nanogenerators were designed and fabricated with improved piezoelectric performances by blending polylactide with hydroxyapatite. The addition of hydroxyapatite significantly improves the crystallinity of polylactide and helps to form hydrogen bonds, which further improved the piezoelectric output performance of these piezoelectric nanogenerators with over three times the open circuit voltage compared with that of pure-polylactide-based devices. Such excellent piezoelectricity of hydroxyapatite/polylactide-based nanogenerators give them great potential for energy harvesting fields.
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http://dx.doi.org/10.3390/mi13060889DOI Listing
May 2022

Dynamic Variation of Ecosystem Services Value under Land Use/Cover Change in the Black Soil Region of Northeastern China.

Int J Environ Res Public Health 2022 Jun 20;19(12). Epub 2022 Jun 20.

School of Public Administration, China University of Geosciences, Wuhan 430074, China.

A better understanding of the dynamic variation in the ecosystem service value (ESV) under land use/cover change (LUCC) is conductive to improving ecosystem services and environmental protection. The present study took Landsat TM/ETM remote sensing images and socio-economic statistic data as data sources and extracted land-use data using RS and GIS technology at 5-year intervals from 1990 to 2020. Then, we interpreted the spatio-temporal characteristics of LUCC and analyzed ESV changes using the value equivalence method in the black soil region of northeastern China (BSRNC). The main results showed that land use changed significantly during the study period. Cultivated land continued to expand, especially paddy areas, which increased by 1.72 × 10 ha, with a relative change of 60.9% over 30 years. However, grassland decreased by 2.47 × 10 ha, with a relative change of -60.6% over 30 years. The ESV showed a declining trend, which decreased by CNY 607.96 million during 1990-2020. The decline in forest and grassland caused a significant decline in the ESV. Furthermore, the ESV sensitivity coefficients were less than one for all of the different categories of ecosystem services. LUCC has a considerable impact on ESV in the BSRNC, resulting in ecosystem function degradation. As a result, future policies must emphasize the relationship between food security and environmental protection in situations of significant land-use change.
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http://dx.doi.org/10.3390/ijerph19127533DOI Listing
June 2022

Epidemiology, Diagnosis, and Prevention of Sparganosis in Asia.

Animals (Basel) 2022 Jun 18;12(12). Epub 2022 Jun 18.

Hunan Provincial the Key Laboratory of Protein Engineering in Animal Vaccine, College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China.

Sparganosis is a zoonotic parasitic disease caused by the larvae (spargana) of the genus , which is widely distributed globally and threatens human health. More than 60 species of have already been identified, and over 2000 cases have been reported. This review summarizes the prevalence of humans, frogs, snakes, and other animals with spargana. Furthermore, the infection mode, distribution, and site are summarized and analyzed. We also describe the epidemiology, molecular diagnosis, and other aspects which are of considerable significance to preventing sparganum.
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http://dx.doi.org/10.3390/ani12121578DOI Listing
June 2022

F-FDG PET visualizes systemic STING agonist-induced lymphocyte activation in preclinical models.

J Nucl Med 2022 Jun 23. Epub 2022 Jun 23.

Department of Molecular and Medical Pharmacology, University of California, United States.

Stimulator of Interferon Genes (STING) is an essential mediator of innate immune recognition of cytosolic DNA, which plays important roles in cancer, cytotoxic therapies, and infections with certain pathogens. While pharmacological STING activation stimulates potent anti-tumor immune responses in animal models, clinically applicable pharmacodynamic biomarkers that inform on the magnitude, duration, and location of immune activation elicited by systemic STING agonists are yet to be described. We investigated whether systemic STING activation induces metabolic alterations in immune cells that can be visualized by Positron Emission Tomography (PET) imaging. C57BL/6 mice were treated with systemic STING agonists and imaged with [F]fluorodeoxyglucose ([F]FDG) PET 24 hrs later. Splenocytes were harvested 6 hrs after STING agonist administration and analyzed by single-cell RNA sequencing and flow cytometry. [F]FDG uptake in total splenocytes and immunomagnetically-enriched splenic B and T lymphocytes from STING agonist-treated mice was measured by gamma counting. In mice bearing prostate or pancreas cancer tumors, the effects of STING agonist treatment on [F]FDG uptake, T lymphocyte activation marker levels, and tumor growth were evaluated. Systemic delivery of structurally distinct STING agonists in mice significantly increased [F]FDG uptake in the spleen. The average spleen SUV in control mice was 1.90 (range 1.56-2.34) compared to 4.55 (range 3.35-6.2) in STING agonist-treated mice ( < 0.0001). Single-cell transcriptional and flow cytometry analyses of immune cells from systemic STING agonist-treated mice revealed enrichment of a glycolytic transcriptional signature in both T and B lymphocytes which correlated with the induction of immune cell activation markers. In tumor-bearing mice, STING agonist administration significantly delayed tumor growth and increased [F]FDG uptake in secondary lymphoid organs. These findings reveal hitherto unknown functional links between STING signaling and immunometabolism and suggest that [F]FDG PET could provide a widely applicable approach to measure the pharmacodynamic effects of systemic STING agonists at a whole-body level and guide their clinical development.
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http://dx.doi.org/10.2967/jnumed.122.264121DOI Listing
June 2022

Associations of polychlorinated biphenyls exposure with plasma glucose and diabetes in general Chinese population: The mediating effect of lipid peroxidation.

Environ Pollut 2022 Jun 20;308:119660. Epub 2022 Jun 20.

Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China. Electronic address:

Polychlorinated biphenyls (PCBs) exposure has been related to the abnormal glucose metabolism and the risk of diabetes. However, the joint effects of various PCBs are uncertain and the potential mechanisms remain unclear. Our objectives were to evaluate the associations of serum PCBs with fasting plasma glucose (FPG) and the risk of diabetes among a general Chinese population, and to estimate the mediating effects of oxidative stress in the above associations. Serum levels of seven indicator-PCBs (PCB-28, 52, 101, 118, 138, 153, and 180) and FPG values were determined among 4498 subjects from the Wuhan-Zhuhai cohort. Oxidative DNA damage biomarker (urinary 8-hydroxy-2'-deoxyguanosine, 8-OHdG) and lipid peroxidation biomarker (urinary 8-isoprostane, 8-iso-PGF) were also measured. Positive relationships of serum PCBs with FPG values as well as the risk of diabetes were observed. With each 1% increment in the natural log-transformed values of wet weight serum PCBs, FPG levels increased a 0.125% for PCB-52, 0.168% for PCB-118, 0.221% for PCB-138, 0.273% for PCB-153, and 0.379% for ΣPCB (the sum of seven PCBs). The adjusted odds ratios of diabetes associated with wet weight PCBs were 1.186 for PCB-52, 1.373 for PCB-118, 1.635 for PCB-153, and 1.456 for ΣPCB. The seven serum PCBs showed positive overall effect on the risk of diabetes. Elevated PCB-28, PCB-52, PCB-118, PCB-138, PCB-153, and ΣPCB were associated with the increased urinary 8-iso-PGF, which was positively related with FPG values. Furthermore, urinary 8-iso-PGF partially mediated the positive associations between PCBs and FPG values, with the mediated proportions ranged from 3.20 to 12.93%. In conclusion, our results suggested that serum PCBs were positively related with increased oxidative stress, FPG values, and the risk of diabetes among a general Chinese population. Serum PCBs mixture had positive overall effect on the risk of diabetes. Lipid peroxidation partly mediated the FPG elevation induced by PCB exposure.
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http://dx.doi.org/10.1016/j.envpol.2022.119660DOI Listing
June 2022

Transcriptomic Characterization of × and Its Implications for Energy Crop Development in the Semiarid Mine Area.

Plants (Basel) 2022 Jun 14;11(12). Epub 2022 Jun 14.

College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 410128, China.

interspecific hybrids have been proved to have better adaptability in marginal lands than their parents. and were used as the parents to develop hybrids. We performed the transcriptome for 110 F1 hybrids of and their parents that had been established on the Loess Plateau mine area, to estimate the population's genetic expression variation, and illuminate the adaptive mechanism of the F1 population. The result speculated that the F1 population has mainly inherited the stress response metabolic pathway of its female parent (), which may be responsible for its higher environmental adaptability and biomass yield compared with male parents. Based on PopART, we assembled a leaf reference transcriptome for (LRTMS) and obtained 8116 high-quality transcripts. When we analyze the differential expression of genes between F1 population and parent, 39 and 56 differentially expressed genes were screened out in the female parent and male parent, respectively. The enrichment analysis showed that pathways of carbohydrate metabolism, lipid metabolism, biosynthesis of secondary metabolites and circadian rhythm-plant played a key role in resisting the harsh environment. The carbohydrate metabolism and lipid metabolism were also significantly enriched, and the synthesis of these substances facilitated the yield. The results provided an insight into breeding hybrids more suited to the harsh environment of the Loess Plateau.
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http://dx.doi.org/10.3390/plants11121568DOI Listing
June 2022

A Liquid Metal-Enhanced Wearable Thermoelectric Generator.

Bioengineering (Basel) 2022 Jun 14;9(6). Epub 2022 Jun 14.

State Grid Jiangsu Electric Power Co., Ltd. Research Institute, Nanjing 211103, China.

It is a key challenge to continuously power personal wearable health monitoring systems. This paper reports a novel liquid metal-enhanced wearable thermoelectric generator (LM-WTEG that directly converts body heat into electricity for powering the wearable sensor system. The gallium-based liquid metal alloys with room-temperature melting point (24~30 °C) and high latent heat density (about 500 MJ/m) are used to design a new flexible finned heat sink, which not only absorbs the heat through the solid-liquid phase change of the LM and enhances the heat release to the ambient air due to its high thermal conduction. The LM finned is integrated with WTEG to present high biaxial flexibility, which could be tightly in contact with the skin. The LM-WTEG could achieve a super high output power density of 275 μW/cm for the simulated heat source (37 °C) with the natural convective heat transfer condition. The energy management unit, the multi-parameter sensors (including temperature, humidity, and accelerometer), and Bluetooth module with a total energy consumption of about 65 μW are designed, which are fully powered from LM-WTEG through harvesting body heat.
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http://dx.doi.org/10.3390/bioengineering9060254DOI Listing
June 2022

Synergistically Enhanced Single-Atom Nickel Catalysis for Alkaline Hydrogen Evolution Reaction.

ACS Appl Mater Interfaces 2022 Jun 22. Epub 2022 Jun 22.

State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, China.

The feature endowing atomic Ni-N-C electrocatalysts with exceptional intrinsic alkaline hydrogen evolution activity is hitherto not well-documented and remains elusive. To this end, we rationally exploited the hierarchical porous carbon microstructures as scaffolds to construct unique Ni-N-S active sites to boost the sluggish Volmer reaction kinetics. Density functional theory reveals an obvious d-band center (ϵ) upshift of the edge-hosted Ni-N-S sites compared with pristine Ni-N, which translates to a more stabilized OH adsorption. Moreover, the synergetic dual-site (Ni and S atom) interplay gives rise to a decoupled regulation of the adsorption strength of intermediate species (OH, H) and thereby energetic water dissociation kinetics. Bearing these in mind, sodium thiosulfate was deliberately adopted as an additive in the molten salt system for controllable synthesis, considering the simultaneous catalyst morphology and active-site modulation. The target Ni-N-S catalyst delivers a low working overpotential (83 [email protected] mA cm) and Tafel slope (100.5 mV dec) comparable to those of representative transition metal-based electrodes in alkaline media. The present study provides insights into the metal active-site geometry and promising synergistic effects over single-atom catalysis.
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http://dx.doi.org/10.1021/acsami.2c05817DOI Listing
June 2022

Effects of cell wall polysaccharides on the bioaccessibility of carotenoids, polyphenols, and minerals: an overview.

Crit Rev Food Sci Nutr 2022 Jun 22:1-14. Epub 2022 Jun 22.

State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi, PR China.

Carotenoids, polyphenols, and minerals (CPMs) are representative bioactive compounds and micronutrients in plant-based foods, showing many potentially positive bioactivities. Bioaccessibility is a prerequisite for bioactivities of CPMs. Cell wall polysaccharides (CWPs) are major structural components of plant cell wall, and they have been proven to affect the bioaccessibility of CPMs in different ways. This review summarizes recent literatures about the effects of CWPs on the bioaccessibility of CPMs and discusses the potential mechanisms. Based on the current findings, CWPs can inhibit the bioaccessibility of CPMs in gastrointestinal tract. The effects of CWPs on the bioaccessibility of polyphenols and minerals mainly attributes to bind between them, while CWPs affect the bioaccessibility of carotenoids by changing the digestive environment. Further, this review overviews the factors (environmental conditions, CWPs properties and CPMs characteristics) affecting the interactions between CWPs and CWPs. This review may help to better design healthy and nutritious foods precisely.
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http://dx.doi.org/10.1080/10408398.2022.2089626DOI Listing
June 2022
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