Publications by authors named "Wei Gong"

822 Publications

Adsorption of Greenhouse Decomposition Products on AgO-SnS and CuO-SnS Surfaces.

ACS Omega 2022 Jun 6;7(24):21043-21051. Epub 2022 Jun 6.

College of Electronic Information Engineering, Chongqing Technology and Business Institute, Chongqing 400052, China.

In this paper, based on density functional theory, the adsorption mechanism and gas sensitivity of AgO/CuO-modified SnS were analyzed. The results were analyzed according to the adsorption energy, total density of states, partial density of states, and frontier molecular orbital theory. The results show that the adsorption of all gas molecules is exothermic. NH, Cl, and CH gases are chemisorbed on the modified SnS surfaces. After gas adsorption, the energy gap of the base changes by more than 10%, which fully shows that the conductivity changes greatly after gas adsorption, which can be reflected in the macroscopic resistance change. AgO-SnS is suitable as a gas sensor for NH gas sensors in terms of moderate adsorption distance, large adsorption energy, charge transfer, and frontier molecular orbital theory, while CuO-SnS is more suitable as a CH gas sensor.
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http://dx.doi.org/10.1021/acsomega.2c01828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9347902PMC
June 2022

Quantitative and direct serum albumin detection by label-free SERS using tunable hydroxyapatite nanostructure for prostate cancer detection.

Anal Chim Acta 2022 Aug 21;1221:340101. Epub 2022 Jun 21.

College of Integrated Traditional Chinese and Western Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China. Electronic address:

With the aid of good biocompatibility and stability with hydroxyapatite (HAp) in protein separation and adsorption fields, we developed a novel extraction-isolation albumin analysis method by relying on the specific adsorption capacity of HAp, combining with surface-enhanced Raman spectroscopy (SERS) for prostate cancer screening. Two different nanostructures of HAp particles, including the HAp flower and HAp sphere, were synthesized with a hydrothermal method, and the targeted binding and extraction abilities of serum albumin of these two HAp particles were compared. By changing the morphology of the nanostructure, the albumin-adsorption capacity of HAp varied significantly. Compared with spherical HAp particles, HAp flower particles have more albumin binding sites per unit area. Thus, the HAp flower displayed the superior capacity for adsorption-release of albumin, which was further employed for clinical prostate cancer screening. Based on the superior adsorption-extraction ability of albumin of HAp flower, serum albumin was adsorbed and extracted by HAp flower from serum samples of prostate cancer patients (n = 30) and healthy volunteers (n = 30), and mixed with silver colloids to perform SERS spectral analysis. The partial least square-support vector machines (PLS-SVM) model is used to analyze the obtained serum albumin SERS spectra and establish the diagnostic model, the diagnostic accuracy was up to 95.00% for differentiating the normal volunteer from prostate patient groups. The results demonstrate that the PLS-SVM model provides superior performance in the classification of a prostate cancer diagnosis. Due to the advantages of simplicity and rapidness, the HAp flower-adsorbed-released albumin combined with SERS was expected to become a promising tool for prostate cancer detection.
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http://dx.doi.org/10.1016/j.aca.2022.340101DOI Listing
August 2022

Scalable and Reconfigurable Green Electronic Textiles with Personalized Comfort Management.

ACS Nano 2022 Aug 5. Epub 2022 Aug 5.

State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, P.R. China.

Electronic textiles, inherited with the wearability of conventional clothes, are deemed fundamental for emerging wearable electronics, particularly in the Internet of Things era. However, the electronic waste produced by electronic textiles will further exacerbate the severe pollution in traditional textiles. Here, we develop a large-scale green electronic textile using renewable bio-based polylactic acid and sustainable eutectic gallium-indium alloys. The green electronic textile is extremely abrasion resistant and can degrade naturally in the environment even if abrasion produces infinitesimal amounts of microplastics. The mass loss and performance change rates of the reconstituted green electronic textiles are all below 5.4% after going through the full-cycle recycling procedure. This green electronic textile delivers high physiological comfort (including electronic comfort and thermal-moisture comfort), enables wireless power supply (without constraints by, e.g., wires and ports), has 2 orders of magnitude better air and moisture permeability than the body requires, and can lower skin temperature by 5.2 °C.
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http://dx.doi.org/10.1021/acsnano.2c04252DOI Listing
August 2022

Coarse sea spray inhibits lightning.

Nat Commun 2022 Aug 2;13(1):4289. Epub 2022 Aug 2.

State Key Laboratory of Information Engineering in Surveying, Mapping, and Remote Sensing, Wuhan University, 430079, Wuhan, China.

The known effects of thermodynamics and aerosols can well explain the thunderstorm activity over land, but fail over oceans. Here, tracking the full lifecycle of tropical deep convective cloud clusters shows that adding fine aerosols significantly increases the lightning density for a given rainfall amount over both ocean and land. In contrast, adding coarse sea salt (dry radius > 1 μm), known as sea spray, weakens the cloud vigor and lightning by producing fewer but larger cloud drops, which accelerate warm rain at the expense of mixed-phase precipitation. Adding coarse sea spray can reduce the lightning by 90% regardless of fine aerosol loading. These findings reconcile long outstanding questions about the differences between continental and marine thunderstorms, and help to understand lightning and underlying aerosol-cloud-precipitation interaction mechanisms and their climatic effects.
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http://dx.doi.org/10.1038/s41467-022-31714-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345860PMC
August 2022

Hepatopancreatoduodenectomy for advanced biliary malignancies.

Chin Med J (Engl) 2022 Aug 2. Epub 2022 Aug 2.

Department of Biliary-Pancreatic Surgery, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.

Background: Hepatopancreatoduodenectomy (HPD) has been considered the only curative treatment for metastatic cholangiocarcinoma and some locally advanced gallbladder cancers (GBCs). However, HPD has not yet been included in treatment guidelines as a standard surgical procedure in consideration of its morbidity and mortality rates. The aim of this study was to evaluate the safety and effectiveness of HPD in treating biliary malignancies.

Methods: The medical records of 57 patients with advanced biliary cancer undergoing HPD from January 2009 to December 2019 were retrospectively retrieved. A case-control analysis was conducted at our department. Patients with advanced GBC who underwent HPD (HPD-GBC group) were compared with a control group (None-HPD-GBC group) Baseline characteristics, preoperative treatments, tumor pathologic features, operative results, and prognosis were assessed.

Results: Thirteen patients with cholangiocarcinoma and 44 patients with GBC underwent HPD at our department. Significant postoperative complications (grade III or greater) and postoperative pancreatic fistula were observed in 24 (42.1%) and 15 (26.3%) patients, respectively. One postoperative death occurred in the present study. Overall survival (OS) was longer in patients with advanced cholangiocarcinoma than in those with GBC (median survival time [MST], 31 months vs. 11 months; P  < 0.001). In the subgroup analysis of patients with advanced GBC, multivariate analysis demonstrated that T4 stage tumors (P = 0.012), N2 tumors (P = 0.001), and positive margin status (P = 0.004) were independently associated with poorer OS. Patients with either one or more prognostic factors exhibited a shorter MST than patients without those prognostic factors (P < 0.001).

Conclusion: HPD could be performed with a relatively low mortality rate and an acceptable morbidity rate in an experienced high- volume center. For patients with advanced GBC without an N2 or T4 tumor, HPD can be a preferable treatment option.
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http://dx.doi.org/10.1097/CM9.0000000000002067DOI Listing
August 2022

Co-assembling of natural drug-food homologous molecule into composite hydrogel for accelerating diabetic wound healing.

Biomater Adv 2022 Jul 25;140:213034. Epub 2022 Jul 25.

National Engineering Research Center of Seafood, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, PR China; Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic University, Dalian 116034, PR China. Electronic address:

Diabetic wound healing is a major clinical challenge due to its vulnerability to bacterial infection and the prolonged inflammation in the wound. Traditional dressings for the healing of diabetic wounds are often suffered from unsatisfactory efficacy and frequent dressing changes which may cause secondary damage. Therefore, it is necessary to find a wound dressing that balances material functionality, degradation, safety, and tissue regeneration. Our recent studies demonstrated that gallic acid (GA) could spontaneously form supramolecular hydrogels at a relatively high concentration. However, a single network of GA hydrogel is prone to degradation, poor adhesion, and poor swelling, and may not be suitable for wound healing dressings. In this study, a composite hydrogel (GAK) was constructed by introducing konjac glucomannan (KGM) into the gel system of gallic acid (GA) and applied to promote diabetic wound healing. The composite hydrogel (GAK) with superior surface adhesion, stability, and swelling properties than the single-network of GA hydrogel. Moreover, in vitro experiments showed that GAK hydrogel had excellent biocompatibility and exhibited antibacterial activity against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). Additionally, the GAK hydrogel could significantly accelerate angiogenesis, collagen deposition, and re-epithelialization during wound healing in diabetic mice, reducing the expression of related inflammatory proteins interleukin-1β (IL-1β), tumor necrosis factor-alpha (TNF-α), and cyclooxygenase-2 (COX-2), and improving the wound closure rate. The findings of this study suggest that this composite hydrogel (GAK) can be an ideal dressing material for accelerating diabetic wound healing.
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http://dx.doi.org/10.1016/j.bioadv.2022.213034DOI Listing
July 2022

Converting a mAb downstream process from batch to continuous using process modeling and process analytical technology.

Biotechnol J 2022 Jul 30:e2100351. Epub 2022 Jul 30.

Shanghai Engineering Research Center of Anti-tumor Biological Drugs, Shanghai Henlius Biotech, Inc., Shanghai, China.

The biopharmaceutical market is driving the revolution from traditional batch processes to continuous manufacturing for higher productivity and lower costs. In this work, a batch mAb downstream process has been converted into an integrated continuous process with the combination of multiple techniques. For process intensification, two batch mode unit operations (protein A capture chromatography, ultrafiltration/diafiltration) were converted into continuous ones; for continuity, surge tanks were used between adjacent steps, and level signals were used to trigger process start or stop, forming a holistic continuous process. For process automation, manual operations (e.g., pH and conductivity adjustment) were changed into automatic operation and load mass was controlled with process analytical technology (PAT). A model-based simulation was applied to estimate the loading conditions for the continuous capture process, resulting in 21% resin capacity utilization and 28% productivity improvement as compared to the batch process. Automatic load mass control of cation exchange chromatography (CEX) was achieved through a customized in-line protein quantity monitoring system, with a difference of less than 1.3% as compared to off-line analysis. Total process time was shortened from 4 days (batch process) to less than 24 hours using the continuous downstream process with the overall productivity of 23.8 g mAb per day for the bench-scale system. Comparable yield and quality data were obtained in three test runs, indicating a successful conversion from a batch process to a continuous process. The insight of this work could be a reference to other similar situations.
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http://dx.doi.org/10.1002/biot.202100351DOI Listing
July 2022

Simultaneous Removal of Cr(VI) and Phenol from Water Using Silica-di-Block Polymer Hybrids: Adsorption Kinetics and Thermodynamics.

Polymers (Basel) 2022 Jul 16;14(14). Epub 2022 Jul 16.

Shaanxi Key Laboratory of Comprehensive Utilization of Tailings Resources, Shaanxi Engineering Research Center for Mineral Resources Clean & Efficient Conversion and New Materials, Shangluo University, Shangluo 726000, China.

Heavy metal ions and organic pollutants often coexist in industrial effluents. In this work, silica-di-block polymer hybrids (SiO-g-PBA-b-PDMAEMA) with two ratios (SiO/BA/DMAEMA = 1/50/250 and 1/60/240) were designed and prepared for the simultaneous removal of Cr(VI) and phenol via a surface-initiated atom-transfer radical polymerization process using butyl methacrylate (BA) as a hydrophobic monomer and 2-(Dimethylamino)ethylmethacrylate (DMAEMA) as a hydrophilic monomer. The removal efficiency of Cr(VI) and phenol by the hybrids reached 88.25% and 88.17%, respectively. The sample with a larger proportion of hydrophilic PDMAEMA showed better adsorption of Cr(VI), and the sample with a larger proportion of hydrophobic PBA showed better adsorption of phenol. In binary systems, the presence of Cr(VI) inhibited the adsorption of phenol, yet the presence of phenol had a negligible effect on the adsorption of Cr(VI). Kinetics studies showed that the adsorption of Cr(VI) and phenol fitted the pseudo-second-order model well. Thermodynamic studies showed that the adsorption behavior of Cr(VI) and phenol were better described by the Langmuir adsorption isotherm equation, and the adsorption of Cr(VI) and phenol were all spontaneous adsorptions driven by enthalpy. The adsorbent still possessed good adsorption capacity for Cr(VI) and phenol after six adsorption-desorption cycles. These findings show that SiO-g-PBA-b-PDMAEMA hybrids represent a satisfying adsorption material for the simultaneous removal of heavy metal ions and organic pollutants.
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http://dx.doi.org/10.3390/polym14142894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324752PMC
July 2022

Role of corneal radius of curvature in early identification of fundus tessellation in children with low myopia.

Br J Ophthalmol 2022 Jul 26. Epub 2022 Jul 26.

Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Eye Diseases, Center of Eye Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, People's Republic of China

Aim: To assess the role of the corneal radius of curvature (CR) in the identification of fundus tessellation in children with low myopia.

Methods: In the cross-sectional study, students aged 9-12 years from 24 primary schools in Shanghai were enrolled by cluster sampling. Participants underwent measurements including cycloplegic refraction and axial length. Fundus images and choroidal thickness were obtained by swept-source optical coherence tomography. Fundus tessellation was classified into four grades according to fundus photographs.

Results: A total of 1127 children with low myopia (spherical equivalence (SE) >-3.00 dioptre (D) but ≤-0.50 D) were included, with a mean age of 10.29±0.60 years and a mean SE of -1.44±0.69 D. Fundus tessellation was found in 591 (52.4%) cases (grade 1: 428, 38.0%; grade 2: 128, 11.4%; grade 3: 35, 3.1%). Choroidal thickness decreased as fundus tessellation grade increased (p trend <0.001). According to regression analysis, higher fundus tessellation grade was independently associated with larger CR (OR, 7.499; 95% CI 2.279 to 24.675, p=0.001). For those with CR >7.9 mm, along with CR, degree and proportion of fundus tessellation increased sharply.

Conclusion: Fundus tessellation existed in more than half of children with low myopia. Preliminary fundus photography conducted in children with low myopia with large CR would be necessary and beneficial to the early management of myopic fundus changes. NCT02980445.
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http://dx.doi.org/10.1136/bjo-2022-321295DOI Listing
July 2022

Cellulose derived Pd nano-catalyst for efficient catalysis.

RSC Adv 2022 Jun 24;12(29):18676-18684. Epub 2022 Jun 24.

School of Materials and Architectural Engineering, Guizhou Normal University Guiyang 550025 China

Using green, environmentally friendly and resource-rich cellulose as a raw material, a ligand-free and highly dispersed palladium (Pd) nano-catalyst was successfully prepared in a facile way. A variety of characterization results showed that the Pd nanoparticles (NPs) were uniformly spread on the cellulose nanoporous microspheres, with an average particle size of ∼2.75 nm. As a carrier, cellulose microspheres with nanoporous structure and rich -OH groups greatly promoted the attachment and distribution of the highly dispersed Pd NPs, along with the diffusion and exchange of reactants, so as to greatly promote the catalytic activity. In the Suzuki-Miyaura coupling reaction, the catalyst of C-Pd exhibited excellent catalytic activity (TOF up to 2126 h), broad applicability, and good recyclability with almost no active loss in 6 continuous runs. This utilizing of bioresources to build catalyst materials is important for sustainable chemistry.
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http://dx.doi.org/10.1039/d2ra02799bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231465PMC
June 2022

Impact of Stress Hyperglycemia on the Timing of Complete Revascularization in Non-diabetes Patients with ST Elevation Myocardial Infarction and Multivessel Disease.

Angiology 2022 Jul 19:33197221115555. Epub 2022 Jul 19.

Department of Cardiology 12667Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Stress hyperglycemia (SHG) is related to an increased risk of mortality in diabetic patients with ST elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). However, data are limited in non-diabetic patients especially in patients with multivessel disease (MVD). In this retrospective study, 742 non-diabetic patients with STEMI and MVD were divided into SHG group and non-SHG group. The overall incidence of SHG was 24.9%. The incidence of no-reflow (NR) phenomenon (18.4% vs 11.8%; = .024) and in-hospital mortality (1.6% vs .2%; = .020) in SHG group were significantly higher than those in non-SHG group. SHG was associated with 30-day MACE (hazard ratio, 4.265; 95% confidence interval (CI), 1.354-13.439; = .013), but not 1-year. Multivariate logistic analysis showed that SHG (odds ratio: 1.691, 95% CI: 1.072-2.667, = .024) was an independent predictor of NR. If complete revascularization (CR) was performed during PPCI, the incidence of NR would be significantly higher. In non-diabetic patients with STEMI and MVD, SHG is associated with increased SF-NR and short-term adverse events, and CR during PPCI further increases the risk of NR.
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http://dx.doi.org/10.1177/00033197221115555DOI Listing
July 2022

Biochemical Characterization and Synthetic Application of WciN and Its Mutants From Serotype 6B.

Front Chem 2022 15;10:914698. Epub 2022 Jun 15.

National Glycoengineering Research Center, Shandong Provincial Key Laboratory of Carbohydrate Chemistry and Glycobiology, Shandong University, Qingdao, China.

The biochemical properties of α-1,3-galactosyltransferase WciN from serotype 6B were systemically characterized with the chemically synthesized Glcα-PP-(CH)-OPh as an acceptor substrate. The site-directed mutation of D38 and A150 residues of WciN was further investigated, and the enzymatic activities of those WciN mutants revealed that A150 residue was the pivotal residue responsible for nucleotide donor recognition and the single-site mutation could completely cause pneumococcus serotype switch. Using WciN and WciN mutants as useful tool enzymes, the disaccharides Galα1,3Glcα-PP-(CH)-OPh and Glcα1,3Glcα-PP-(CH)-OPh were successfully prepared in multi-milligram scale in high yields.
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http://dx.doi.org/10.3389/fchem.2022.914698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240355PMC
June 2022

Field attenuation characteristics of hearing protectors and differences in estimating their attenuation with different methods.

J Acoust Soc Am 2022 06;151(6):3979

Personal Safety Division, 3M China Ltd., No. 9 Nanxiang Er Road, Science City, Guangzhou, Guangdong 510663, People's Republic of China.

This study investigated the field attenuation characteristics of hearing protection devices (HPDs), differences in estimating the protection provided by HPDs with different rating methods, and suggested potential solutions on proper use of attenuation ratings to estimate the protection provided by HPDs. The binaural octave-band personal attenuation values obtained from 1583 field users with 3985 fits on seven HPDs were used to compute the field-rating values as described in the International Organization for Standardization standard ISO 4869-2:2018, and the octave-band noise reduction (OB NR) values of each fit for 100 noises. The estimated protection for 100 noises was compared within different rating methods. The OB NR values varied with quality of fit, noise spectra, and HPD. The quality of fit was a crucial factor. Deviations in estimating the protection given by different rating methods varied with HPD and quality of fit. The misuse of subtracting the single number rating (SNR) from A-weighted noise level magnified these deviations. The multiple-number rating gave a more accurate estimation of protection provided by the earmuff compared to SNR. Improving the quality of fit and including C-weighted noise level can reduce the variability and deviation in protection estimation for different noises.
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http://dx.doi.org/10.1121/10.0011512DOI Listing
June 2022

Circulating MMP-12 as Potential Biomarker in Evaluating Disease Severity and Efficacy of Sublingual Immunotherapy in Allergic Rhinitis.

Mediators Inflamm 2022 12;2022:3378035. Epub 2022 Jun 12.

Department of Otolaryngology Head and Neck Surgery, The Affiliated Changsha Central Hospital, Hengyang Medical School of University of South China, Changsha, Hunan 410000, China.

Background: Allergic rhinitis (AR) is a highly heterogeneous disease, and allergen-specific immunotherapy (AIT) is an effective treatment. This study aims to evaluate the circulating mas-related G protein-coupled receptor-X2 (MRGPRX2) and matrix metalloproteinase-12 (MMP-12) levels in evaluating disease severity and predicting efficacy of SLIT in AR patients.

Methods: We enrolled 110 moderate-severe persist AR patients (AR group) and 40 healthy controls (HC group). Circulating levels of MRGPRX2 and MMP-12 were measured, and their associations with disease severity were evaluated. All AR patients were assigned to receive sublingual immunotherapy (SLIT), and the efficacy was evaluated, and serum samples were collected at 1 year and 3 years after treatment. The correlations between serum MRGPRX2 and MMP-12 and clinical efficacy were assessed.

Results: The serum concentrations of MRGPRX2 and MMP-12 were significantly higher in the AR group than the HC group, and the elevated MMP-12 levels were correlated with VAS and TNSS, and serum MRGPRX2 levels were correlated with VAS. Finally, 100 and 80 patients completed 1-year and 3-year follow-up and were classified into effective and ineffective groups. Serum MRGPRX2 and MMP-12 levels were lower in the effective group than the ineffective group. Although serum MRGPRX2 and MMP-12 levels did not significantly change after 1 year SLIT, serum MMP-12 levels were decreased 3 years post-SLIT than baseline and 1 year post-SLIT levels. Receiver operating characteristic (ROC) showed that serum MMP-12 was a potential biomarker for predicting the efficacy of SLIT.

Conclusion: Serum MRGPRX2 and MMP-12 appeared to be promising biological indicators in reflecting disease severity in AR patients. Moreover, circulating MMP-12 might serve as a reliable predictor for clinical responsiveness of SLIT.
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http://dx.doi.org/10.1155/2022/3378035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9207019PMC
June 2022

Intracranial drainage versus extracranial shunt in the treatment of intracranial arachnoid cysts: a meta-analysis.

Childs Nerv Syst 2022 Jun 20. Epub 2022 Jun 20.

Department of Neurosurgery, The First College of Clinical Medical Science, China Three Gorges University & Institute of Neurology, Yichang Central People's Hospital, China Three Gorges University, Yichang, 443003, China.

Objective: To review the literature and analyze the efficacy and safety of two surgery procedures, intracranial drainage and extracranial shunt, for intracranial arachnoid cysts.

Methods: We searched the online Medlars, PubMed, and Cochrane Central electronic databases and collected studies of patients with intracranial arachnoid cysts treated with two surgical methods.

Results: The meta-analysis results shows that there were not statistically significant in clinical symptoms improvement, cyst reduction, the improvement of epilepsy, epidural hematoma, cerebrospinal fluid leak, and recurrence rate (P > 0.05, with RR values are 0.99, 0.94, 1.00, 0.94, 1.21, and 0.75 respectively). There was statistically significant in the occurrence rate of intracranial infection (P = 0.0004, RR = 0.28). The intracranial drainage group was lower than extracranial shunt group.

Conclusion: The results indicated that the efficacy and safety of two surgery procedures are similar in the treatment of intracranial arachnoid cysts, but the intracranial drainage was better than extracranial shunt in reducing the risk of intracranial infection.
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http://dx.doi.org/10.1007/s00381-022-05585-6DOI Listing
June 2022

Contextual Fear Learning and Extinction in the Primary Visual Cortex of Mice.

Neurosci Bull 2022 Jun 15. Epub 2022 Jun 15.

Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310012, China.

Fear memory contextualization is critical for selecting adaptive behavior to survive. Contextual fear conditioning (CFC) is a classical model for elucidating related underlying neuronal circuits. The primary visual cortex (V1) is the primary cortical region for contextual visual inputs, but its role in CFC is poorly understood. Here, our experiments demonstrated that bilateral inactivation of V1 in mice impaired CFC retrieval, and both CFC learning and extinction increased the turnover rate of axonal boutons in V1. The frequency of neuronal Ca activity decreased after CFC learning, while CFC extinction reversed the decrease and raised it to the naïve level. Contrary to control mice, the frequency of neuronal Ca activity increased after CFC learning in microglia-depleted mice and was maintained after CFC extinction, indicating that microglial depletion alters CFC learning and the frequency response pattern of extinction-induced Ca activity. These findings reveal a critical role of microglia in neocortical information processing in V1, and suggest potential approaches for cellular-based manipulation of acquired fear memory.
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http://dx.doi.org/10.1007/s12264-022-00889-8DOI Listing
June 2022

Safety of a Sustainably Produced, Bioengineered, Nature-Identical Salidroside Compound.

Nutrients 2022 Jun 1;14(11). Epub 2022 Jun 1.

DoubleRainbow Biosciences Inc., Lexington, MA 02421, USA.

Bioactive phytochemicals such as salidroside have been studied to understand the beneficial effects of , an herbaceous plant used in traditional medicine to increase energy and treat a variety of health issues. However, Rhodiola plants are often slow-growing, and many are endangered in their native habitats. Thus, there is a need for safe, alternative supplies of key phytochemicals from Rhodiola. The salidroside subject of this safety study is a synthetic biology product from fermentation of a bioengineered that produces salidroside. Here, we present comprehensive test results that support the safety of salidroside manufactured via a patented sustainable bioengineering manufacturing process. In vitro bacterial reverse mutation assays with the bioengineered salidroside show no mutagenicity in any of the concentrations tested. In vivo toxicity studies in rats show no adverse effects from the salidroside product. Based on the results of these studies, we conclude that the bioengineered salidroside discussed here is not genotoxic and demonstrates a no-observed-adverse-effect level (NOAEL) at least 2000 mg/kg bw/day in male and female Sprague-Dawley rats. This study supports that the salidroside compound produced using bioengineered is a viable alternative to salidroside produced from harvested Rhodiola plants for use as a dietary supplement, food ingredient, or potentially as a pharmaceutical product.
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http://dx.doi.org/10.3390/nu14112330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9183058PMC
June 2022

Preparation, characterization, and pharmacokinetics of rivaroxaban cocrystals with enhanced in vitro and in vivo properties in beagle dogs.

Int J Pharm X 2022 Dec 21;4:100119. Epub 2022 May 21.

State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.

Rivaroxaban (RIV) is a direct Factor Xa inhibitor anticoagulant, but the oral bioavailability of RIV is estimated to be only 60% due to its poor solubility. The aim of the present study was to improve the solubility and bioavailability of RIV. Five cocrystals-p-hydroxybenzoic acid (HBA), 2,4-dihydroxybenzoic acid (DBA), nicotinamide (NA), isonicotinamide (IA), and succinic acid (SA)-were used as cofomers and were successfully obtained and characterized by powder X-ray diffraction, thermal analysis, and Fourier transform infrared spectra. RIV-DBA and RIV-HBA cocrystals showed obvious improvements in solubility, dissolution (under sink conditions), and intrinsic dissolution rates versus RIV. Moreover, the dissolution of RIV-HBA, RIV-DBA, and RIV-SA cocrystals under non-sink conditions showed obvious "spring and parachute" patterns. The in vitro permeability levels in a Caco-2 cell model of RIV-DBA and RIV-IA cocrystals were significantly improved versus RIV. Pharmacokinetic studies in beagle dogs showed that RIV-DBA and RIV-HBA cocrystals had higher bioavailability than RIV. The enhancements in solubility and bioavailability indicate the potential of RIV cocrystals as a better candidate for the treatment of thrombosis versus RIV.
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http://dx.doi.org/10.1016/j.ijpx.2022.100119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160491PMC
December 2022

Epigenetic alterations of CXCL5 in Cr(VI)-induced carcinogenesis.

Sci Total Environ 2022 Sep 1;838(Pt 1):155713. Epub 2022 Jun 1.

Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address:

Chronic exposure to hexavalent chromium compounds [Cr(VI)] is associated with an increased risk of cancers, but the molecular mechanisms remain to be elucidated. In this study, we found that CXCL5 levels in peripheral blood monocytes (PBMCs) and plasma from workers with occupational exposure to Cr(VI) were dramatically upregulated compared to non-exposure healthy subjects, and plasma C-X-C Motif Chemokine Ligand 5 (CXCL5) CXCL5 levels were positively correlated with Cr concentrations in subjects' toenails. Zinc chromate exposed mice showed higher levels of CXCL5 and its receptor CXCR2 in lung tissues, and in PBMCs. Similar CXCL5 upregulation was evident in Cr(VI)-induced transformed (Cr-T) cells with long-term Cr(VI) treatment. Mechanistic studies showed that elevated CXCL5 expression levels were regulated by Cr(VI)-induced histone modifications and DNA hypomethylation, and that the c-Myc/p300 complex was a key upstream regulator of histone H3 acetylation. CXCL5 overexpression promoted Cr(VI)-induced the epithelial to mesenchyme transition (EMT) by upregulating zinc finger E-box binding homeobox 1 (ZEB1) to promote tumor development. Our findings identify a novel mechanism by which CXCL5 is upregulated and promotes EMT and carcinogenesis upon chronic Cr(VI) exposure. Our work also implies that CXCL5 mRNA and protein levels will elevate in PBMCs and serum after occupational Cr(VI) exposure, which may be a potential target and biomarker for cancer prevention and health surveillance among populations exposed to Cr(VI).
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http://dx.doi.org/10.1016/j.scitotenv.2022.155713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9290188PMC
September 2022

Nonocclusive mesenteric ischemia caused by type B aortic dissection: a case report.

BMC Surg 2022 Jun 3;22(1):214. Epub 2022 Jun 3.

Second Affiliated Hospital of Soochow University, Suzhou, China.

Background: Nonocclusive mesenteric ischemia (NOMI) is defined as acute intestinal ischemia because of decreased blood flow in mesenteric vessels. Only a few cases of NOMI that occur secondary to aortic dissection (AD) have been reported, resulting in the lack of sufficient knowledge of diagnosis and treatment.

Case Presentation: We aimed to report a case of NOMI caused by type B Aortic Dissection. A 26-year-old male patient was transferred to our hospital with the diagnose of NOMI and aortic dissection in April 2018. The abdominal computed tomography (CT) assists the diagnosis of paralytic intestinal obstruction, intestinal wall pneumatosis, and perforation. Emergency laparotomy revealed that the bowel wall supplied by the superior mesenteric artery (SMA) was pale with the palpable but weak pulsation of the parietal artery. The small intestine was extremely dilated with a paper-thin, fragile wall that was ruptured easily and could not be sutured. In this case, extensive resection and segmental drainage were done. Postoperatively, the digestive tract was reconstructed. However, the patient suffered from iron deficiency anemia and short bowel syndrome eight months later, and unfortunately died from long-term complications.

Conclusion: Aortic dissection leads to continuous decrease in blood pressure and blood flow to the SMA, considering as a predisposing factor for NOMI. During the treatment, extensive resection and segmental drainage are the optimal surgical strategy, which can make benefit in emergencies especially.
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http://dx.doi.org/10.1186/s12893-022-01656-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166441PMC
June 2022

Janus wireframe DNA cube-based 3D nanomachine for rapid and stable fluorescence detection of exosomal microRNA.

Biosens Bioelectron 2022 Sep 20;212:114405. Epub 2022 May 20.

Chongqing Medical University, Chongqing, 400016, China; Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, 400714, China; Department of Clinical Laboratory, Chongqing General Hospital, Chongqing, 400016, China. Electronic address:

Exosomal microRNAs (miRNAs) have been demonstrated to be credible biomarkers for the diagnosis and monitoring of tumors. Nevertheless, developing simple, rapid, and stable biosensing strategies that are capable of accurately detecting exosomal miRNAs remains a challenge. Herein, an accelerated and biostable three-dimensional (3D) nanomachine based on Janus wireframe DNA cube was constructed for sensitive fluorescence measurement of exosomal miRNA. The Janus wireframe DNA cube could propel target exosomal miRNA-21 rapid movement on its surface by catalytic hairpin assembly (CHA), releasing a massive fluorescence signal. Benefiting from the Janus wireframe DNA cube, the developed 3D nanomachine exhibited significantly improved reaction rate and enhanced biostability in complex biofluids compared to conventional CHA. As a result, this fluorescence biosensing strategy achieved rapid, stable, and single-step detection of exosomal miRNA-21 with the detection limit down to the picomole level. Therefore, this work offers a brief sensing tool for nucleic acid biomarkers detection, which has great application potential in tumor diagnosis.
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http://dx.doi.org/10.1016/j.bios.2022.114405DOI Listing
September 2022

Limiting Factors of Detectivity in Near-Infrared Colloidal Quantum Dot Photodetectors.

ACS Appl Mater Interfaces 2022 Jun 26;14(22):25812-25823. Epub 2022 May 26.

Faculty of Information Technology, Key Laboratory of Opto-Electronics Technology, Ministry of Education, Beijing University of Technology, Beijing 100124, China.

Lead sulfide colloidal quantum dots (PbS CQDs) have shown great potential in photodetectors owing to their promising optical properties, especially their strong and tunable absorption. However, the limitation of the specific detectivity (*) in CQD near-infrared (NIR) photodetectors remains unknown due to the ambiguous noise analysis. Therefore, a clear understanding of the noise current is critically demanded. Here, we elucidate that the noise current is the predominant factor limiting *, and the noise is highly dependent on the trap densities in halide-passivated PbS films and the carriers injected from the Schottky contact (EDT-passivated PbS films/metal). It is found that the thickness of CQDs is proportional to their interface trap density, while it is inversely proportional to their minimal bulk trap density. A balance point can be reached at a certain thickness (136 nm) to minimize the trap density, giving rise to the improvement of *. Utilizing thicker PbS-EDT films broadens the width of the tunneling barrier and thereby reduces the carrier injection, contributing to a further enhancement of *. The limiting factors of * determined in this work not only explain the physical mechanism of the influence on detection sensitivity but also give guidance to the design of high-performance CQD photodetectors.
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http://dx.doi.org/10.1021/acsami.2c06620DOI Listing
June 2022

Multifactor Logistic Analysis to Explore the Risk Factors of Safety Risks in the Transport of Critically Ill Patients with ICU and the Improvement of Nursing Strategies.

Comput Math Methods Med 2022 14;2022:3330667. Epub 2022 May 14.

Department of Cardiac Intensive Care Unit, Yantai Yuhuangding Hospital, Yantai 264000, Shandong Province, China.

Objective: Multivariate logistic analysis was employed to explore the risk factors of safety risks in the transport of critically ill patients with ICU and the improvement of nursing strategies.

Methods: Two hundred critical transport patients with ICU treated in our hospital from January 2019 to April 2021 were enrolled. According to the occurrence of unsafe events in transit, the patients were assigned to the control group (165 cases without unsafe events, = 165) and the study group (35 cases with safety incidents, = 35). Multivariate logistic analysis was employed to explore the risk factors of safety risks in the transport of critically ill patients with ICU and to enhance nursing strategies.

Results: (1) General data of the subjects: among the 200 critically ill patients with ICU who needed in-hospital transport, the age ranged from 18 to 85 years with an average age of 52.48 ± 3.31, including 89 males and 111 females. There were 35 cases of gastrointestinal bleeding, 16 cases of respiratory failure, 23 cases of heart failure, 43 cases of myocardial infarction, 26 cases of cerebrovascular accident, 14 cases of ectopic pregnancy, 25 cases of severe injury, and 18 cases of mechanical ventilation. There were 35 cases in the study group with accidents and 45 cases in group B without accidents. (2) Among the 200 patients, 35 patients had complications during the transit process in the intermediate people's court, with an incidence rate of 17.5%. It included blood pressure fluctuation ( = 6), artificial airway obstruction ( = 6), decrease in blood oxygen saturation ( = 10), dyspnea ( = 5), fall pain ( = 3), elevated intracranial pressure ( = 2), and other factors ( = 3). There exhibited no significant difference in blood oxygen saturation at each time point during transport ( > 0.05). There exhibited no significant difference in SpO before transport. The comparison of 5 min and 10 min blood oxygen saturation during transit in the study group was lower compared to the control group ( < 0.05). (3) In a univariate analysis of safety risks for critically ill ICU patients, home escorts did not show significant differences in hospital transport for critically ill ICU patients ( > 0.05). There were significant differences in terms of age, patient's condition, transport escort, auxiliary ventilation, means of transport, uncarried drugs and goods, and carrying pipeline ( < 0.05). The results of multivariate logistic regression analysis indicated that age, patient's condition, transport escort, auxiliary ventilation, means of transport, uncarried drugs and goods, and carrying pipeline were the risk factors affecting the safe transport of critically ill patients ( < 0.05).

Conclusion: Age, patient's condition, transport escort, auxiliary ventilation, means of transport, uncarried drugs and goods, and carrying pipeline are the independent risk factors that affect the safe transport of emergency or ICU critically ill patients. Therefore, in order to reduce the risk of transshipment, we must enhance the safety awareness of escorts, strengthen the management and training of escorts, promote rules and regulations, and formulate dangerous plans, so as to eliminate the occurrence of unsafe factors.
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http://dx.doi.org/10.1155/2022/3330667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124074PMC
May 2022

PREX1 depletion ameliorates high-fat diet-induced non-alcoholic fatty liver disease in mice and mitigates palmitic acid-induced hepatocellular injury via suppressing the NF-κB signaling pathway.

Toxicol Appl Pharmacol 2022 Aug 20;448:116074. Epub 2022 May 20.

Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. Electronic address:

Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver diseases worldwide. Oxidative stress has been considered a key factor in the pathogenesis of NAFLD. Phosphatidylinositol (3,4,5)-trisphosphate-dependent Rac exchanger 1 (PREX1), a guanine nucleotide exchange factor for Rac, has been associated with inflammation and oxidative stress. This study aimed to investigate the biological function of PREX1 in the progression of NAFLD. Male C57BL/6 mice were fed a high-fat diet for 12 weeks to induce NAFLD in vivo. Adeno-associated virus type 8-mediated liver-specific PREX1 depletion was employed to investigate the role of PREX1 in the progression of high-fat diet-induced NAFLD. Murine hepatocyte cell line AML-12 was stimulated with palmitic acid for 24 h to induce steatosis in vitro. PREX1 depletion was carried out by transfection with PREX1 small interfering RNA. Results showed that PREX1 depletion exerted protective effects against lipid accumulation, oxidative stress and inflammation and inhibited activation of the nuclear factor-κB (NF-κB) signaling pathway in vivo and in vitro. Subsequently, NF-κB inhibitor BAY11-7082 was applied to investigate the role of the NF-κB signaling pathway in the protective effect of PREX1 inhibition against NAFLD. We confirmed that PREX1 inhibition mitigated palmitic acid-induced hepatocellular inflammation mainly via the NF-κB signaling pathway and lipid accumulation and oxidative stress at least partly via the NF-κB signaling pathway. This study highlights the biological function of PREX1 in the pathogenesis of NAFLD.
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http://dx.doi.org/10.1016/j.taap.2022.116074DOI Listing
August 2022

Alizarin, a nature compound, inhibits the growth of pancreatic cancer cells by abrogating NF-κB activation.

Int J Biol Sci 2022 28;18(7):2759-2774. Epub 2022 Mar 28.

Department of General Surgery, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.

The current performance of nature compounds in antitumor field is gradually attracted more and more attention, we discovered a nature active ingredient alizarin possess potent natural reductive NF-κB activity to against pancreatic cancer. However, the preclinical pharmacology and therapeutic effect, and the underlying mechanisms of alizarin in inhibiting pancreatic cancer are still unclear. After high-throughput screening, this is the first report that alizarin can induce a potent inhibitory effect against pancreatic cancer cells. Alizarin induced cell cycle arrest and promoted cell apoptosis by inhibiting TNF-α-stimulated NF-κB activity and nuclear translocation, and inactivated its related TNF-α-TAK1-NF-κB signaling cascade followed by downregulation of NF-κB target genes involved in cell apoptosis (Bcl-2, Bcl-xL, XIAP) and in the cell cycle and growth (cyclin D, c-myc). Due to the abrogation of NF-κB activity, combination of alizarin and gemcitabine exerted a better inhibitory effect on pancreatic cancer. In summary, natural component alizarin, inhibited cell proliferation and induced apoptosis and through targeting of the NF-κB signaling cascade with minimal toxicity, which combine with gemcitabine, can significantly enhance the antitumor capability, playing a synergistic effect. Therefore, alizarin may play a role in reversing gemcitabine resistance caused by overactivated NF-κB in clinical application in the future.
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http://dx.doi.org/10.7150/ijbs.70567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066114PMC
March 2022

Long non-coding RNA LSAMP-1 is down-regulated in non-small cell lung cancer and predicts a poor prognosis.

Cancer Cell Int 2022 May 6;22(1):181. Epub 2022 May 6.

The State Key Lab of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, 151 Yanjiangxi Road, Guangzhou, 510120, China.

Background: Long noncoding RNAs (lncRNAs) are emerging as master regulators for gene expression and thus play a vital role in human tumorigenesis and progression. But the involvement of novel lncRNAs in non-small cell lung cancer (NSCLC) remains largely unelucidated.

Methods: A total of 170 NSCLC and their adjacent non-tumor tissues were enrolled to detect the expression of Lnc-LSAMP-1 by RT-qPCR. The effects of Lnc-LSAMP-1 on cell proliferation, migration, invasion and drug-sensitivity were determined by in vitro and in vivo experiments. The proteins that interact with Lnc-LSAMP-1were confirmed by RNA pull-down assay. RNA-sequencing were used to identify the potential targets of Lnc-LSAMP-1 in NSCLC.

Results: We found that Lnc-LSAMP-1 was significantly down-regulated in 170 cases of NSCLC tissues when compared to their adjacent non-cancerous tissues. Loss expression of Lnc-LSAMP-1 was notably correlated with unfavorable prognosis of NSCLC patients. The ectopic expression of Lnc-LSAMP-1 drastically inhibited lung cancer cell proliferation, viability, invasion and migration ability, arrested cell cycle and facilitated apoptosis. Chemotherapy sensitization experiments showed that over-expressed Lnc-LSAMP-1 enhanced the inhibition of cell proliferation induced by TKI. Mechanistically, Lnc-LSAMP-1-LSAMP formed a complex which could protect the degradation of LSAMP gene, and thus exerted crucial roles in NSCLC progression and TKI targeted treatment.

Conclusions: Consequently, our findings highlight the function and prognostic value of Lnc-LSAMP-1 in NSCLC and provide potential novel therapeutic targets and prognostic biomarkers for patients with NSCLC.
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http://dx.doi.org/10.1186/s12935-022-02592-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9074231PMC
May 2022

Effect of obstructive sleep apnoea on coronary collateral vessel development in patients with ST-segment elevation myocardial infarction.

Respirology 2022 Aug 4;27(8):653-660. Epub 2022 May 4.

Center for Coronary Artery Disease, Division of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Background And Objective: The impact of obstructive sleep apnoea (OSA) in the setting of acute ST-segment elevation myocardial infarction (STEMI) is complex and divergent. This study aimed to investigate the association between OSA and coronary collateral vessel (CCV) development in patients with STEMI.

Methods: The present study prospectively screened 282 STEMI patients with an overnight sleep study. OSA was defined as apnoea-hypopnoea index (AHI) ≥15 events/h. The coronary angiograms were used for the assessment of Rentrop grades representing CCVs.

Results: Among 119 patients enrolled, 60 patients had OSA (50.4%). The prevalence of CCV development (Rentrop grade ≥ 2) was significantly higher in OSA group than in the non-OSA group (43.3% vs. 5.1%, p < 0.001). There was a parallel increase in the Rentrop grades associated with OSA severity and worsening of hypoxaemia indicators (minimum arterial oxygen saturation [SaO ], mean SaO and time with SaO below 90%). After adjustment for clinical and angiographic characteristics, and pre-procedure medications that might interact with OSA, AHI as a continuous variable (OR 1.11, 95% CI 1.08-1.21, p < 0.001) and the presence of OSA (OR 11.41, 95% CI 2.70-48.15, p = 0.001) were both associated with dramatically higher incidence of CCV development.

Conclusion: Our study demonstrated that the presence of OSA might augment CCV development in STEMI patients. The potential protective effects and mechanisms of OSA in the acute setting of STEMI should be further investigated in larger studies.
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http://dx.doi.org/10.1111/resp.14277DOI Listing
August 2022

Rheological behavior, crystallization properties, and foaming performance of chain-extended poly (lactic acid) by functionalized epoxy.

RSC Adv 2021 Oct 5;11(52):32799-32809. Epub 2021 Oct 5.

The Institute of Materials and Construction of Guizhou Normal University Guiyang China

The inherently linear poly (lactic acid) suffers unsatisfying foaming behavior due to its low melt strength and poor crystallization properties. To overcome this drawback, a random terpolymer of ethylene, acrylic ester and glycidyl methacrylate (EGMA) was employed to improve the rheological behavior, crystallization properties, and foaming performance of poly (lactic acid) (PLA) through a chain extension reaction. The branched/micro-crosslinked structure formed by the chain extension reaction between EGMA and PLA effectively improved the dynamic rheological properties of PLA. As the content of EGMA increased from 0 wt% to 20 wt%, the crystal nucleation and crystal growth rate of various PLA samples have been significantly accelerated, resulting in a larger number and smaller size of spherulites, and the crystallinity of various PLA samples increased from 7.9% to 38.54%. The cell size of various PLA foams decreased from 53.5 to 22.0 μm and the cell density increased from 3.5 × 10 cells per cm to 2.5 × 10 cells per cm, meanwhile, the cellular morphology of PLA foam was obviously improved. Moreover, the actual weight loss of PLA foams reached 26.1%, which is higher than the theoretical weight loss.
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http://dx.doi.org/10.1039/d1ra06382kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9042192PMC
October 2021

Estimation of Occupational Noise-Induced Hearing Loss Using Kurtosis-Adjusted Noise Exposure Levels.

Ear Hear 2022 Apr 21. Epub 2022 Apr 21.

Auditory Research Laboratory, State University of New York at Plattsburgh, NY, USA.

Objectives: Studies have shown that in addition to energy, kurtosis plays an important role in the assessment of hearing loss caused by complex noise. The objective of this study was to investigate how to use noise recordings and audiometry collected from workers in industrial environments to find an optimal kurtosis-adjusted algorithm to better evaluate hearing loss caused by both continuous noise and complex noise.

Design: In this study, the combined effects of energy and kurtosis on noise-induced hearing loss (NIHL) were investigated using data collected from 2601 Chinese workers exposed to various industrial noises. The cohort was divided into three subgroups based on three kurtosis (β) levels (K1: 3 ≤ β ≤ 10, K2: 10 <β ≤ 50, and K3: β > 50). Noise-induced permanent threshold shift at test frequencies 3, 4, and 6 kHz (NIPTS346) was used as the indicator of NIHL. Predicted NIPTS346 was calculated using the ISO 1999 model for each participant, and the actual NIPTS was obtained by correcting for age and sex using non-noise-exposed Chinese workers (n = 1297). A kurtosis-adjusted A-weighted sound pressure level normalized to a nominal 8-hour working day (LAeq,8h) was developed based on the kurtosis categorized group data sets using multiple linear regression. Using the NIPTS346 and the LAeq.8h metric, a dose-response relationship for three kurtosis groups was constructed, and the combined effect of noise level and kurtosis on NIHL was investigated.

Results: An optimal kurtosis-adjusted LAeq,8h formula with a kurtosis adjustment coefficient of 6.5 was established by using the worker data. The kurtosis-adjusted LAeq,8h better estimated hearing loss caused by various complex noises. The analysis of the dose-response relationships among the three kurtosis groups showed that the NIPTS of K2 and K3 groups was significantly higher than that of K1 group in the range of 70 dBA ≤ LAeq,8h < 85 dBA. For 85 dBA ≤ LAeq,8h ≤ 95 dBA, the NIPTS346 of the three groups showed an obvious K3 > K2 > K1. For LAeq,8h >95 dBA, the NIPTS346 of the K2 group tended to be consistent with that of the K1 group, while the NIPTS346 of the K3 group was significantly larger than that of the K1 and K2 groups. When LAeq,8h is below 70 dBA, neither continuous noise nor complex noise produced significant NIPTS346.

Conclusions: Because non-Gaussian complex noise is ubiquitous in many industries, the temporal characteristics of noise (i.e., kurtosis) must be taken into account in evaluating occupational NIHL. A kurtosis-adjusted LAeq,8h with an adjustment coefficient of 6.5 allows a more accurate prediction of high-frequency NIHL. Relying on a single value (i.e., 85 dBA) as a recommended exposure limit does not appear to be sufficient to protect the hearing of workers exposed to complex noise.
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http://dx.doi.org/10.1097/AUD.0000000000001223DOI Listing
April 2022
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