Webster K Cavenee

Webster K Cavenee

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Webster K Cavenee

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Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling.

Cell Metab 2019 Jul 9. Epub 2019 Jul 9.

Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093, USA; Department of Pathology, UCSD School of Medicine, La Jolla, CA 92093, USA; Moores Cancer Center, UCSD School of Medicine, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2019.06.014DOI Listing
July 2019

Oncogenic mutations at the EGFR ectodomain structurally converge to remove a steric hindrance on a kinase-coupled cryptic epitope.

Proc Natl Acad Sci U S A 2019 May 26;116(20):10009-10018. Epub 2019 Apr 26.

Institute for Research in Biomedicine (IRB Barcelona), the Barcelona Institute of Science and Technology, 08028 Barcelona, Catalonia, Spain;

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http://dx.doi.org/10.1073/pnas.1821442116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525488PMC
May 2019

Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling.

Cell Metab 2019 Jul 9. Epub 2019 Jul 9.

Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093, USA; Department of Pathology, UCSD School of Medicine, La Jolla, CA 92093, USA; Moores Cancer Center, UCSD School of Medicine, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2019.06.014DOI Listing
July 2019

Rethinking Glioblastoma Therapy: MDA-9/Syntenin Targeted Small Molecule.

ACS Chem Neurosci 2019 Mar 25;10(3):1121-1123. Epub 2019 Jan 25.

Department of Human and Molecular Genetics , Virginia Commonwealth University, School of Medicine , Richmond , Virginia 23298 , United States.

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http://dx.doi.org/10.1021/acschemneuro.9b00016DOI Listing
March 2019

Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair.

Cancer Cell 2019 Mar 28;35(3):504-518.e7. Epub 2019 Feb 28.

Ludwig Institute for Cancer Research, San Diego Branch, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0660, USA; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, USA; Department of Pathology, School of Medicine, University of California at San Diego, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.01.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424615PMC
March 2019

MDA-7/IL-24 regulates the miRNA processing enzyme DICER through downregulation of MITF.

Proc Natl Acad Sci U S A 2019 03 6;116(12):5687-5692. Epub 2019 Mar 6.

Department of Human and Molecular Genetics, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298;

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http://dx.doi.org/10.1073/pnas.1819869116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431152PMC
March 2019

Metabolic reprogramming in the pathogenesis of glioma: Update.

Neuropathology 2019 Feb 4;39(1):3-13. Epub 2019 Jan 4.

Department of Pathology, Division of Pathological Neuroscience, Tokyo Women's Medical University, Tokyo, Japan.

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http://doi.wiley.com/10.1111/neup.12535
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http://dx.doi.org/10.1111/neup.12535DOI Listing
February 2019

Reply to Yoshida: Delineating critical roles of MDA-9 in protective autophagy-mediated anoikis resistance in human glioma stem cells.

Proc Natl Acad Sci U S A 2018 08 7;115(33):E7654-E7655. Epub 2018 Aug 7.

Department of Human and Molecular Genetics, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298;

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http://dx.doi.org/10.1073/pnas.1811113115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099876PMC
August 2018

MDA-9/Syntenin regulates protective autophagy in anoikis-resistant glioma stem cells.

Proc Natl Acad Sci U S A 2018 05 14;115(22):5768-5773. Epub 2018 May 14.

Department of Human and Molecular Genetics, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298;

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http://dx.doi.org/10.1073/pnas.1721650115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984507PMC
May 2018

Fluorescence Molecular Tomography for In Vivo Imaging of Glioblastoma Xenografts.

J Vis Exp 2018 04 26(134). Epub 2018 Apr 26.

Ludwig Institute for Cancer Research; Moores Cancer Center, School of Medicine, University of California, San Diego; Department of Medicine, School of Medicine, University of California, San Diego.

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http://dx.doi.org/10.3791/57448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100979PMC
April 2018

Interleukin-13 receptor alpha 2 cooperates with EGFRvIII signaling to promote glioblastoma multiforme.

Nat Commun 2017 12 4;8(1):1913. Epub 2017 Dec 4.

Laboratory of Cancer Gene Therapy, Cellular and Molecular Research Division, Humphrey Oei Institute of Cancer Research, National Cancer Centre, 11, Hospital Drive, Singapore, 169610, Singapore.

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http://dx.doi.org/10.1038/s41467-017-01392-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715073PMC
December 2017

Selective replication of oncolytic virus M1 results in a bystander killing effect that is potentiated by Smac mimetics.

Proc Natl Acad Sci U S A 2017 06 12;114(26):6812-6817. Epub 2017 Jun 12.

Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China;

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http://dx.doi.org/10.1073/pnas.1701002114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495246PMC
June 2017

Precision cancer therapy is impacted by oncogene-dependent epigenome remodeling.

NPJ Precis Oncol 2017 20;1(1). Epub 2017 Mar 20.

2Ludwig Institute for Cancer Research, La Jolla, CA 92093 USA.

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http://dx.doi.org/10.1038/s41698-017-0005-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871882PMC
March 2017

An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers.

Cancer Cell 2016 Nov 13;30(5):683-693. Epub 2016 Oct 13.

Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093, USA; Department of Pathology, UCSD School of Medicine, La Jolla, CA 92093, USA; Moores Cancer Center, UCSD School of Medicine, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479636PMC
November 2016

mTORC2 activity in brain cancer: Extracellular nutrients are required to maintain oncogenic signaling.

Bioessays 2016 09 18;38(9):839-44. Epub 2016 Jul 18.

Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.1002/bies.201600026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501721PMC
September 2016

Cancer metabolism as a central driving force of glioma pathogenesis.

Brain Tumor Pathol 2016 Jul 13;33(3):161-8. Epub 2016 Jun 13.

Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA, 92093, USA.

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http://dx.doi.org/10.1007/s10014-016-0265-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488809PMC
July 2016

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary.

Acta Neuropathol 2016 06 9;131(6):803-20. Epub 2016 May 9.

Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1007/s00401-016-1545-1DOI Listing
June 2016

mTORC2 dictates Warburg effect and drug resistance.

Cell Cycle 2014 28;13(7):1053-4. Epub 2014 Feb 28.

Ludwig Institute for Cancer Research; University of California, San Diego; La Jolla, CA USA; Moores Cancer Center; University of California, San Diego; La Jolla, CA USA; Department of Pathology; University of California, San Diego; La Jolla, CA USA.

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http://dx.doi.org/10.4161/cc.28377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013152PMC
May 2016

mTORC2 and Metabolic Reprogramming in GBM: at the Interface of Genetics and Environment.

Brain Pathol 2015 Nov;25(6):755-9

Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA.

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http://dx.doi.org/10.1111/bpa.12307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636016PMC
November 2015

EGFR Mutation Promotes Glioblastoma through Epigenome and Transcription Factor Network Remodeling.

Mol Cell 2015 Oct 8;60(2):307-18. Epub 2015 Oct 8.

Ludwig Institute for Cancer Research, La Jolla, CA 92093, USA; Department of Pathology, UCSD School of Medicine, La Jolla, CA 92093, USA; Moores Cancer Center, UCSD School of Medicine, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609298PMC
October 2015

PRUNE2 is a human prostate cancer suppressor regulated by the intronic long noncoding RNA PCA3.

Proc Natl Acad Sci U S A 2015 Jul 15;112(27):8403-8. Epub 2015 Jun 15.

David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030; University of New Mexico Cancer Center, University of New Mexico School of Medicine, Albuquerque, NM 87131; Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM 87131; Department of Genitourinary Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030; Division of Hematology/Oncology, University of New Mexico School of Medicine, Albuquerque, NM 87131;

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http://dx.doi.org/10.1073/pnas.1507882112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500257PMC
July 2015

Glucose-dependent acetylation of Rictor promotes targeted cancer therapy resistance.

Proc Natl Acad Sci U S A 2015 Jul 13;112(30):9406-11. Epub 2015 Jul 13.

Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093; Moores Cancer Center, University of California San Diego, La Jolla, CA 92093; Department of Pathology, University of California San Diego, La Jolla, CA 92093

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http://dx.doi.org/10.1073/pnas.1511759112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522814PMC
July 2015

Heterogeneity of epidermal growth factor receptor signalling networks in glioblastoma.

Nat Rev Cancer 2015 May 9;15(5):302-10. Epub 2015 Apr 9.

Ludwig Institute for Cancer Research and the Department of Pathology, University of California San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1038/nrc3918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4875778PMC
May 2015

A urokinase receptor-Bim signaling axis emerges during EGFR inhibitor resistance in mutant EGFR glioblastoma.

Cancer Res 2015 Jan 28;75(2):394-404. Epub 2014 Nov 28.

Ludwig Institute for Cancer Research, La Jolla, California. Department of Pathology, University of California San Diego, La Jolla, California. The Moores Cancer Center, University of California San Diego, La Jolla, California.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297573PMC
January 2015

Mutational landscape of gastric adenocarcinoma in Chinese: implications for prognosis and therapy.

Proc Natl Acad Sci U S A 2015 Jan 12;112(4):1107-12. Epub 2015 Jan 12.

Department of Epidemiology and Biostatistics, Department of Pathology, and Department of Gastrointestinal Surgery, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, People's Republic of China;

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http://dx.doi.org/10.1073/pnas.1422640112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313862PMC
January 2015

Emerging function of mTORC2 as a core regulator in glioblastoma: metabolic reprogramming and drug resistance.

Cancer Biol Med 2014 Dec;11(4):255-63

1 Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093, USA ; 2 Neuro-Oncology Program, University of California, Los Angeles, CA 90095, USA.

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http://www.cancerbiomed.org/index.php/cocr/article/view/823/
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http://dx.doi.org/10.7497/j.issn.2095-3941.2014.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296088PMC
December 2014

mTORC2 in the center of cancer metabolic reprogramming.

Trends Endocrinol Metab 2014 Jul 21;25(7):364-73. Epub 2014 May 21.

Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tem.2014.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077930PMC
July 2014

Efficient synthesis of chloro-derivatives of sialosyllactosylceramide, and their enhanced inhibitory effect on epidermal growth factor receptor activation.

Oncol Lett 2014 Apr 17;7(4):933-940. Epub 2014 Feb 17.

Institute of Paris Molecular Chemistry, University Pierre & Marie Curie Paris 6, Paris 75005, France ; Institute for Interdisciplinary Research, Jianghan University, Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, P.R. China.

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http://dx.doi.org/10.3892/ol.2014.1887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961331PMC
April 2014

Glioblastoma: from molecular pathology to targeted treatment.

Annu Rev Pathol 2014 5;9:1-25. Epub 2013 Aug 5.

Department of Neurology and Neuro-Oncology Program, University of California, Los Angeles, California 90095; email:

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http://dx.doi.org/10.1146/annurev-pathol-011110-130324DOI Listing
March 2014

Suppression of microRNA-9 by mutant EGFR signaling upregulates FOXP1 to enhance glioblastoma tumorigenicity.

Cancer Res 2014 Mar 16;74(5):1429-39. Epub 2014 Jan 16.

Authors' Affiliations: Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, California; Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio; Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri; and Department of Neurosurgery, Memorial Sloan-Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-2117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947420PMC
March 2014

Therapeutic resistance in cancer: microRNA regulation of EGFR signaling networks.

Cancer Biol Med 2013 Dec;10(4):192-205

Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.7497/j.issn.2095-3941.2013.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860350PMC
December 2013

The mTOR kinase inhibitors, CC214-1 and CC214-2, preferentially block the growth of EGFRvIII-activated glioblastomas.

Clin Cancer Res 2013 Oct 12;19(20):5722-32. Epub 2013 Sep 12.

Authors' Affiliations: Laboratory of Molecular Pathology, Ludwig Institute for Cancer Research; Moores Cancer Center; University of California San Diego, La Jolla; Celgene Corporation, San Diego; Department of Neurological Surgery and Brain Tumor Research Center, University of California at San Francisco, San Francisco; California Institute of Technology, Pasadena; Henry Singleton Brain Tumor Program; Jonsson Comprehensive Cancer Center; Department of Neurology, David Geffen UCLA School of Medicine; Department of Molecular and Medical Pharmacology; UCLA Medical Scientist Training Program, University of California, Los Angeles, Los Angeles, California; Celgene Corporation, Summit, New Jersey; Department of Radiation Oncology, Ohio State University Comprehensive Cancer Center and Arthur G. James Cancer Hospital, Columbus, Ohio; Department of Neurological, Neuropsychological, Morphological and Movement Sciences, University of Verona, Verona, Italy; INSERM; Metabolomics Platform, Institut Gustave Roussy, Villejuif; Université Paris Descartes/Sorbonne Paris Cité; Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers; and Pôle de Biologie, Hôpital Européen Georges Pompidou, Paris, France.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815450PMC
October 2013

Genetic driver events in premalignancy: LOH validated for marking the risk of oral cancer.

Cancer Prev Res (Phila) 2012 Sep 21;5(9):1073-4. Epub 2012 Aug 21.

Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.1158/1940-6207.CAPR-12-0220DOI Listing
September 2012

Crosstalk between the urokinase-type plasminogen activator receptor and EGF receptor variant III supports survival and growth of glioblastoma cells.

Proc Natl Acad Sci U S A 2011 Sep 6;108(38):15984-9. Epub 2011 Sep 6.

Department of Pathology, University of California at San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1073/pnas.1113416108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179096PMC
September 2011

MicroRNA-138 modulates DNA damage response by repressing histone H2AX expression.

Mol Cancer Res 2011 Aug 21;9(8):1100-11. Epub 2011 Jun 21.

Howard Hughes Medical Institute, Division of Human Biology, University of Washington, Seattle, Washington, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-11-0007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157593PMC
August 2011

Heterogeneity maintenance in glioblastoma: a social network.

Cancer Res 2011 Jun 31;71(12):4055-60. Epub 2011 May 31.

Department of Pathology, University of California, San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-0153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117065PMC
June 2011

Analysis of phosphotyrosine signaling in glioblastoma identifies STAT5 as a novel downstream target of ΔEGFR.

J Proteome Res 2011 Mar 14;10(3):1343-52. Epub 2011 Feb 14.

Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1021/pr101075eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049961PMC
March 2011

Therapeutic targeting of epidermal growth factor receptor in human cancer: successes and limitations.

Chin J Cancer 2011 Jan;30(1):5-12

Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, California 92093-0660, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359794PMC
January 2011

KLF6 Gene and early melanoma development in a collagen I-rich extracellular environment.

J Natl Cancer Inst 2010 Aug 21;102(15):1131-47. Epub 2010 Jul 21.

Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.

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http://dx.doi.org/10.1093/jnci/djq218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2914760PMC
August 2010

Escape from targeted inhibition: the dark side of kinase inhibitor therapy.

Cell Cycle 2010 May 16;9(9):1661-2. Epub 2010 May 16.

Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.4161/cc.9.9.11592DOI Listing
May 2010

Mutant EGFR is required for maintenance of glioma growth in vivo, and its ablation leads to escape from receptor dependence.

Proc Natl Acad Sci U S A 2010 Feb 21;107(6):2616-21. Epub 2010 Jan 21.

Ludwig Institute for Cancer Research, University of California, San Diego, CA 92039, USA.

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http://dx.doi.org/10.1073/pnas.0914356107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823874PMC
February 2010

A drosophila model for EGFR-Ras and PI3K-dependent human glioma.

PLoS Genet 2009 Feb 13;5(2):e1000374. Epub 2009 Feb 13.

Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1000374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2636203PMC
February 2009

Guilt by association: PAX3-FOXO1 regulates gene expression through selective destabilization of the EGR1 transcription factor.

Cell Cycle 2008 Apr 22;7(7):837-41. Epub 2008 Jan 22.

The Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.4161/cc.7.7.5652DOI Listing
April 2008

Genome-wide mapping and analysis of active promoters in mouse embryonic stem cells and adult organs.

Genome Res 2008 Jan 27;18(1):46-59. Epub 2007 Nov 27.

Ludwig Institute for Cancer Research, UCSD School of Medicine, La Jolla, California 92093-0653, USA.

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http://dx.doi.org/10.1101/gr.6654808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2134779PMC
January 2008

Malignant astrocytic glioma: genetics, biology, and paths to treatment.

Genes Dev 2007 Nov;21(21):2683-710

Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1101/gad.1596707DOI Listing
November 2007

PAX3-FOXO1 controls expression of the p57Kip2 cell-cycle regulator through degradation of EGR1.

Proc Natl Acad Sci U S A 2007 Nov 6;104(46):18085-90. Epub 2007 Nov 6.

Ludwig Institute for Cancer Research, Biomedical Sciences Graduate Program, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0660, USA.

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http://dx.doi.org/10.1073/pnas.0708910104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2084300PMC
November 2007

Uncovering therapeutic targets for glioblastoma: a systems biology approach.

Cell Cycle 2007 Nov 20;6(22):2750-4. Epub 2007 Aug 20.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://www.cdpcenter.org/files/pubs/Huang2007Cell%20Cycle.pd
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http://dx.doi.org/10.4161/cc.6.22.4922DOI Listing
November 2007

The 2007 WHO classification of tumours of the central nervous system.

Acta Neuropathol 2007 Aug 6;114(2):97-109. Epub 2007 Jul 6.

Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1007/s00401-007-0243-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1929165PMC
August 2007

Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma.

Proc Natl Acad Sci U S A 2007 Jul 23;104(31):12867-72. Epub 2007 Jul 23.

Department of Biological Engineering and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1073/pnas.0705158104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1937558PMC
July 2007

The efficacy of epidermal growth factor receptor-specific antibodies against glioma xenografts is influenced by receptor levels, activation status, and heterodimerization.

Clin Cancer Res 2007 Mar;13(6):1911-25

Oncogenic Signalling Laboratory and Tumor Targeting Program, Ludwig Institute for Cancer Research, Melbourne Centre, Austin Hospital, Heidelberg, Melbourne, Australia.

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http://dx.doi.org/10.1158/1078-0432.CCR-06-1453DOI Listing
March 2007

Transgenic mice expressing PAX3-FKHR have multiple defects in muscle development, including ectopic skeletal myogenesis in the developing neural tube.

Transgenic Res 2006 Oct 2;15(5):595-614. Epub 2006 Sep 2.

Childrens Hospital Los Angeles Research Institute, Los Angeles, CA 90027, USA.

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http://dx.doi.org/10.1007/s11248-006-9011-9DOI Listing
October 2006

PCAF modulates PTEN activity.

J Biol Chem 2006 Sep 7;281(36):26562-8. Epub 2006 Jul 7.

Ludwig Institute for Cancer Research, San Diego Branch, CA, USA.

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http://dx.doi.org/10.1074/jbc.M605391200DOI Listing
September 2006

Mammalian target of rapamycin inhibition promotes response to epidermal growth factor receptor kinase inhibitors in PTEN-deficient and PTEN-intact glioblastoma cells.

Cancer Res 2006 Aug;66(16):7864-9

Department of Pathology and Laboratory Medicine, Henry E. Singleton Brain Tumor Program, Howard Hughes Medical Institute, David Geffen School of Medicine, University of California at Los Angeles, CA 90095-1732, USA.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-04-4392DOI Listing
August 2006

Identification of EGFRvIII-derived CTL epitopes restricted by HLA A0201 for dendritic cell based immunotherapy of gliomas.

J Neurooncol 2006 Jan;76(1):23-30

Department of Neurosurgery, University of Minnesota Medical School, 2001 Sixth Street, Minneapolis, SE, MN 55455, USA.

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http://dx.doi.org/10.1007/s11060-005-3280-7DOI Listing
January 2006