Wayne W Hancock

Wayne W Hancock

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Wayne W Hancock

Publications by authors named "Wayne W Hancock"

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Sirtuin-1 in immunotherapy: A Janus-headed target.

J Leukoc Biol 2019 Aug 3;106(2):337-343. Epub 2019 Jan 3.

Division of Nephrology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

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http://doi.wiley.com/10.1002/JLB.2RU1118-422R
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http://dx.doi.org/10.1002/JLB.2RU1118-422RDOI Listing
August 2019

Lymphatic impairment leads to pulmonary tertiary lymphoid organ formation and alveolar damage.

J Clin Invest 2019 04 4;129(6):2514-2526. Epub 2019 Apr 4.

Department of Medicine and Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1172/JCI125044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546450PMC
April 2019

Complementary Roles of GCN5 and PCAF in Foxp3+ T-Regulatory Cells.

Cancers (Basel) 2019 Apr 18;11(4). Epub 2019 Apr 18.

Transplant Immunology, Department of Pathology & Laboratory Medicine & Biesecker Center for Study of Pediatric Liver Diseases, Children's Hospital of Philadelphia, and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.3390/cancers11040554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520961PMC
April 2019

MEF2 and the tumorigenic process, hic sunt leones.

Biochim Biophys Acta Rev Cancer 2018 12 5;1870(2):261-273. Epub 2018 Jun 5.

Department of Medicine, Università degli Studi di Udine, P.le Kolbe 4, 33100 Udine, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2018.05.007DOI Listing
December 2018

How little is known about the role of human FOXP3+ Tregs in tumors.

Expert Opin Ther Targets 2018 08 19;22(8):655-658. Epub 2018 Jul 19.

a Pathology and Laboratory Medicine, Perelman School of Medicine , University of Pennsylvania , Philadelphia , PA , USA.

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http://dx.doi.org/10.1080/14728222.2018.1499728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294964PMC
August 2018

Proximity Ligation Assay to Quantify Foxp3 Acetylation in Regulatory T Cells.

Methods Mol Biol 2017 ;1510:287-293

Division of Nephrology, Department of Pediatrics, The Children's Hospital of Philadelphia, University of Pennsylvania, 3615 Civic Center Boulevard, 916C Abramson Research Center, Philadelphia, PA, 19104-4318, USA.

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http://link.springer.com/10.1007/978-1-4939-6527-4_21
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http://dx.doi.org/10.1007/978-1-4939-6527-4_21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353615PMC
January 2018

Utility of IL-2 Complexes in Promoting the Survival of Murine Orthotopic Forelimb Vascularized Composite Allografts.

Transplantation 2018 01;102(1):70-78

Division of Plastic Surgery, Department of Orthopaedic Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1097/TP.0000000000001852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994770PMC
January 2018

Human lung tumor FOXP3+ Tregs upregulate four "Treg-locking" transcription factors.

JCI Insight 2017 Aug 17;2(16). Epub 2017 Aug 17.

Division of Transplant Immunology, Department of Pathology and Laboratory Medicine, and Biesecker Center for Pediatric Liver Diseases, Children's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1172/jci.insight.94075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621877PMC
August 2017

Histone/protein deacetylase 11 targeting promotes Foxp3+ Treg function.

Sci Rep 2017 08 17;7(1):8626. Epub 2017 Aug 17.

Division of Transplant Immunology, Department of Pathology and Laboratory Medicine, and Biesecker Center for Pediatric Liver Diseases, Children's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1038/s41598-017-09211-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561267PMC
August 2017

Regulatory T cell signatures in liver transplant recipients successfully weaned from immunosuppression: Getting from here to there.

Liver Transpl 2017 07;23(7):875-877

Pathology and Laboratory Medicine Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1002/lt.24786DOI Listing
July 2017

Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments.

Cell Metab 2017 Jun 13;25(6):1282-1293.e7. Epub 2017 Apr 13.

Division of Nephrology and Department of Pediatrics, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.12.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462872PMC
June 2017

Ubiquitin-specific Protease-7 Inhibition Impairs Tip60-dependent Foxp3+ T-regulatory Cell Function and Promotes Antitumor Immunity.

EBioMedicine 2016 Nov 15;13:99-112. Epub 2016 Oct 15.

Division of Transplant Immunology, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2016.10.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264272PMC
November 2016

Standardization, Evaluation, and Area-Under-Curve Analysis of Human and Murine Treg Suppressive Function.

Methods Mol Biol 2016 ;1371:43-78

Division of Transplant Immunology, Department of Pathology and Laboratory Medicine and Biesecker Center for Pediatric Liver Disease, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1007/978-1-4939-3139-2_4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554116PMC
August 2016

Isoform-Selective HDAC Inhibitor Therapy for Transplantation: Are We Ready for HDAC6?

Authors:
Wayne W Hancock

Transplantation 2016 08;100(8):1597-8

1 Division of Transplant Immunology, Department of Pathology and Laboratory Medicine, and Biesecker Center for Pediatric Liver Diseases, Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1097/TP.0000000000001209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961515PMC
August 2016

HDAC5 controls the functions of Foxp3(+) T-regulatory and CD8(+) T cells.

Int J Cancer 2016 May 19;138(10):2477-86. Epub 2016 Jan 19.

Division of Nephrology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1002/ijc.29979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484398PMC
May 2016

Targeting Sirtuin-1 prolongs murine renal allograft survival and function.

Kidney Int 2016 May 16;89(5):1016-1026. Epub 2016 Mar 16.

Division of Nephrology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia and University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2015.12.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834143PMC
May 2016

Regulation of T cell differentiation and alloimmunity by the cyclin-dependent kinase inhibitor p18ink4c.

PLoS One 2014 10;9(3):e91587. Epub 2014 Mar 10.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America; Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia Research Institute, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0091587PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948896PMC
March 2016

Thiol-Based Potent and Selective HDAC6 Inhibitors Promote Tubulin Acetylation and T-Regulatory Cell Suppressive Function.

ACS Med Chem Lett 2015 Nov 5;6(11):1156-61. Epub 2015 Oct 5.

Department of Medicinal Chemistry & Pharmacognosy, University of Illinois at Chicago , Chicago, Illinois 60612, United States.

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http://dx.doi.org/10.1021/acsmedchemlett.5b00303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4645251PMC
November 2015

Essential role of mitochondrial energy metabolism in Foxp3⁺ T-regulatory cell function and allograft survival.

FASEB J 2015 Jun 13;29(6):2315-26. Epub 2015 Feb 13.

*Department of Pediatrics, Division of Nephrology, Center for Mitochondrial and Epigenomic Medicine, and Department of Pathology and Laboratory Medicine, Division of Transplant Immunology, and Biesecker Center for Pediatric Liver Disease, Children's Hospital of Philadelphia and University of Pennsylvania; Department of Medicine, Center for Sleep and Circadian Neurobiology, and Department of Physiology and Institute of Diabetes, Obesity, and Metabolism, University of Pennsylvania; and Division of Traumatology and Surgical Critical Care, Hospital of the University of Pennsylvania, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1096/fj.14-268409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447222PMC
June 2015

The inflammatory phenotype of the fibrous plate is distinct from the liver and correlates with clinical outcome in biliary atresia.

Pathol Res Pract 2015 Mar 6;211(3):252-60. Epub 2015 Jan 6.

Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.prp.2014.12.003DOI Listing
March 2015

An optimized disaggregation method for human lung tumors that preserves the phenotype and function of the immune cells.

J Leukoc Biol 2015 Jan 30;97(1):201-9. Epub 2014 Oct 30.

Departments of *Surgery and Medicine, University of Pennsylvania School of Medicine, and Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA

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http://dx.doi.org/10.1189/jlb.5TA0814-373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4771617PMC
January 2015

Two histone/protein acetyltransferases, CBP and p300, are indispensable for Foxp3+ T-regulatory cell development and function.

Mol Cell Biol 2014 Nov 25;34(21):3993-4007. Epub 2014 Aug 25.

Division of Transplant Immunology, Department of Pathology and Laboratory Medicine and Biesecker Center for Study of Pediatric Liver Diseases, Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA

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http://dx.doi.org/10.1128/MCB.00919-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386456PMC
November 2014

Effects of histone deacetylase inhibitors on alloresponses.

Authors:
Wayne W Hancock

Lancet Oncol 2014 Jan 30;15(1):10-1. Epub 2013 Nov 30.

Division of Transplantation Immunology, Department of Pathology and Laboratory Medicine, Biesecker Center for Pediatric Liver Diseases, Children's Hospital of Philadelphia, and University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(13)70537-0DOI Listing
January 2014

Mbd2 promotes foxp3 demethylation and T-regulatory-cell function.

Mol Cell Biol 2013 Oct 26;33(20):4106-15. Epub 2013 Aug 26.

Division of Transplantation Immunology, Department of Pathology and Laboratory Medicine & Biesecker Center for Pediatric Liver Diseases.

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http://dx.doi.org/10.1128/MCB.00144-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811679PMC
October 2013

Inhibition of p300 impairs Foxp3⁺ T regulatory cell function and promotes antitumor immunity.

Nat Med 2013 Sep 18;19(9):1173-7. Epub 2013 Aug 18.

1] Division of Transplant Immunology, Department of Pathology and Laboratory Medicine and Biesecker Center for Study of Pediatric Liver Diseases, Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA. [2].

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http://dx.doi.org/10.1038/nm.3286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793393PMC
September 2013

Foxp3+ T-regulatory cells require DNA methyltransferase 1 expression to prevent development of lethal autoimmunity.

Blood 2013 May 26;121(18):3631-9. Epub 2013 Feb 26.

Division of Transplant Immunology, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

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http://dx.doi.org/10.1182/blood-2012-08-451765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643763PMC
May 2013

Cyclin-dependent kinase 2 controls peripheral immune tolerance.

J Immunol 2012 Dec 7;189(12):5659-66. Epub 2012 Nov 7.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.4049/jimmunol.1202313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518671PMC
December 2012

Indoleamine 2,3-dioxygenase and metabolites protect murine lung allografts and impair the calcium mobilization of T cells.

Am J Respir Cell Mol Biol 2012 Oct 19;47(4):405-16. Epub 2012 Apr 19.

Division of Pulmonary Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.

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http://www.atsjournals.org/doi/abs/10.1165/rcmb.2011-0438OC
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http://dx.doi.org/10.1165/rcmb.2011-0438OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488632PMC
October 2012

Substrate rigidity regulates human T cell activation and proliferation.

J Immunol 2012 Aug 25;189(3):1330-9. Epub 2012 Jun 25.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.4049/jimmunol.1102757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401283PMC
August 2012

Inhibitory effects of pirfenidone on dendritic cells and lung allograft rejection.

Transplantation 2012 Jul;94(2):114-22

Division of Respiratory Medicine, Department of Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1097/TP.0b013e3182584879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402635PMC
July 2012

Histone deacetylases 6 and 9 and sirtuin-1 control Foxp3+ regulatory T cell function through shared and isoform-specific mechanisms.

Sci Signal 2012 Jun 19;5(229):ra45. Epub 2012 Jun 19.

Division of Nephrology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

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http://stke.sciencemag.org/cgi/doi/10.1126/scisignal.2002873
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http://dx.doi.org/10.1126/scisignal.2002873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603571PMC
June 2012

Structural and biological features of FOXP3 dimerization relevant to regulatory T cell function.

Cell Rep 2012 Jun 15;1(6):665-75. Epub 2012 Jun 15.

State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China 200031.

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http://dx.doi.org/10.1016/j.celrep.2012.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401381PMC
June 2012

Two lysines in the forkhead domain of foxp3 are key to T regulatory cell function.

PLoS One 2012 11;7(1):e29035. Epub 2012 Jan 11.

Laboratory of Medicine, Division of Transplant Immunology, Department of Pathology, School of Medicine, University of Pennsylvania, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0029035PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256141PMC
May 2012

HDAC inhibitor therapy in autoimmunity and transplantation.

Ann Rheum Dis 2012 Apr;71 Suppl 2:i46-54

Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4318, USA.

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http://dx.doi.org/10.1136/annrheumdis-2011-200593DOI Listing
April 2012

Histone/protein deacetylases and T-cell immune responses.

Blood 2012 Mar 12;119(11):2443-51. Epub 2012 Jan 12.

Division of Transplant Immunology, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104-4318, USA.

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http://dx.doi.org/10.1182/blood-2011-10-292003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311271PMC
March 2012

Helios expression is a marker of T cell activation and proliferation.

PLoS One 2011 30;6(8):e24226. Epub 2011 Aug 30.

Division of Transplant Immunology, Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0024226PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168881PMC
February 2012

Serum cytokine profiles associated with early allograft dysfunction in patients undergoing liver transplantation.

Liver Transpl 2012 Feb;18(2):166-76

Penn Transplant Institute, Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://doi.wiley.com/10.1002/lt.22451
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http://dx.doi.org/10.1002/lt.22451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266982PMC
February 2012

Second-generation histone deacetylase 6 inhibitors enhance the immunosuppressive effects of Foxp3+ T-regulatory cells.

J Med Chem 2012 Jan 5;55(2):639-51. Epub 2012 Jan 5.

Drug Discovery Program, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois 60612, United States.

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http://pubs.acs.org/doi/10.1021/jm200773h
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http://dx.doi.org/10.1021/jm200773hDOI Listing
January 2012

Herpesvirus entry mediator regulates hypoxia-inducible factor-1α and erythropoiesis in mice.

J Clin Invest 2011 Dec 14;121(12):4810-9. Epub 2011 Nov 14.

Marlene and Stewart Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1172/JCI57332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225994PMC
December 2011

Rationale for HDAC inhibitor therapy in autoimmunity and transplantation.

Authors:
Wayne W Hancock

Handb Exp Pharmacol 2011 ;206:103-23

Division of Transplant Immunology, Department of Pathology and Laboratory Medicine, 916B Abramson Research Center, Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4318, USA.

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http://dx.doi.org/10.1007/978-3-642-21631-2_6DOI Listing
November 2011

Histone/protein deacetylases control Foxp3 expression and the heat shock response of T-regulatory cells.

Curr Opin Immunol 2011 Oct 26;23(5):670-8. Epub 2011 Jul 26.

Division of Nephrology, Department of Pediatrics, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, USA.

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http://dx.doi.org/10.1016/j.coi.2011.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3190028PMC
October 2011

Immunogenetics and transplantation.

Curr Opin Immunol 2011 Oct 8;23(5):639-40. Epub 2011 Aug 8.

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http://dx.doi.org/10.1016/j.coi.2011.07.009DOI Listing
October 2011

Histone deacetylase 6 and heat shock protein 90 control the functions of Foxp3(+) T-regulatory cells.

Mol Cell Biol 2011 May 28;31(10):2066-78. Epub 2011 Mar 28.

Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine, 3615 Civic Center Boulevard, Philadelphia, Pennsylvania 19104-4318, USA.

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http://dx.doi.org/10.1128/MCB.05155-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3133361PMC
May 2011

Sirtuin-1 targeting promotes Foxp3+ T-regulatory cell function and prolongs allograft survival.

Mol Cell Biol 2011 Mar 3;31(5):1022-9. Epub 2011 Jan 3.

Division of Nephrology, Department of Pediatrics, The Children’s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-4318, USA.

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http://dx.doi.org/10.1128/MCB.01206-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3067815PMC
March 2011

Histone acetyltransferase mediated regulation of FOXP3 acetylation and Treg function.

Curr Opin Immunol 2010 Oct 24;22(5):583-91. Epub 2010 Sep 24.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.coi.2010.08.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967626PMC
October 2010

Histone/protein deacetylase inhibitors increase suppressive functions of human FOXP3+ Tregs.

Clin Immunol 2010 Sep 15;136(3):348-63. Epub 2010 May 15.

Division of Transplant Immunology, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA 19104-4318, USA.

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http://dx.doi.org/10.1016/j.clim.2010.04.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917523PMC
September 2010

Inhibition of HDAC9 increases T regulatory cell function and prevents colitis in mice.

Gastroenterology 2010 Feb 29;138(2):583-94. Epub 2009 Oct 29.

Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, Pennsylvania 19104-4318, USA.

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http://dx.doi.org/10.1053/j.gastro.2009.10.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369426PMC
February 2010

Immunomodulatory effects of deacetylase inhibitors: therapeutic targeting of FOXP3+ regulatory T cells.

Nat Rev Drug Discov 2009 Dec 26;8(12):969-81. Epub 2009 Oct 26.

Division of Transplant Immunology, Children's Hospital of Philadelphia, Philadelphia 19104, USA.

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http://dx.doi.org/10.1038/nrd3031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2884987PMC
December 2009

Three distinct domains contribute to nuclear transport of murine Foxp3.

PLoS One 2009 Nov 18;4(11):e7890. Epub 2009 Nov 18.

Division of Transplant Immunology, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0007890PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774276PMC
November 2009

Deacetylase inhibition increases regulatory T cell function and decreases incidence and severity of collagen-induced arthritis.

Exp Mol Pathol 2009 Oct 3;87(2):99-104. Epub 2009 Jul 3.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104-6082, USA.

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http://dx.doi.org/10.1016/j.yexmp.2009.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753738PMC
October 2009

Pirfenidone inhibits T-cell activation, proliferation, cytokine and chemokine production, and host alloresponses.

Transplantation 2009 Aug;88(3):330-8

Department of Medicine, Children's Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, MA, USA.

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http://dx.doi.org/10.1097/TP.0b013e3181ae3392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726969PMC
August 2009

BTLA targeting modulates lymphocyte phenotype, function, and numbers and attenuates disease in nonobese diabetic mice.

J Leukoc Biol 2009 Jul 21;86(1):41-51. Epub 2009 Apr 21.

Surgical Medical Research Institute, Department of Surgery, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada.

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http://doi.wiley.com/10.1189/jlb.1107753
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http://dx.doi.org/10.1189/jlb.1107753DOI Listing
July 2009

Reduced cytotoxic function of effector CD8+ T cells is responsible for indoleamine 2,3-dioxygenase-dependent immune suppression.

J Immunol 2009 Jul 29;183(2):1022-31. Epub 2009 Jun 29.

Division of Pulmonary Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.4049/jimmunol.0900408DOI Listing
July 2009

Using histone deacetylase inhibitors to enhance Foxp3(+) regulatory T-cell function and induce allograft tolerance.

Immunol Cell Biol 2009 Mar-Apr;87(3):195-202. Epub 2009 Jan 27.

Department of Pathology and Laboratory Medicine, Stokes Research Institute and Biesecker Pediatric Liver Center, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104-4318, USA.

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http://dx.doi.org/10.1038/icb.2008.106DOI Listing
May 2009

Foxp3 processing by proprotein convertases and control of regulatory T cell function.

J Biol Chem 2009 Feb 24;284(9):5709-16. Epub 2008 Dec 24.

Division of Gastroenterology Hepatology and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA 19104-4318, USA.

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http://dx.doi.org/10.1074/jbc.M807322200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2645825PMC
February 2009

TGF-beta and IL-6 signals modulate chromatin binding and promoter occupancy by acetylated FOXP3.

Proc Natl Acad Sci U S A 2008 Sep 8;105(37):14023-7. Epub 2008 Sep 8.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104-6082, USA.

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http://dx.doi.org/10.1073/pnas.0806726105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2544572PMC
September 2008

Prolongation of cardiac and islet allograft survival by a blocking hamster anti-mouse CXCR3 monoclonal antibody.

Transplantation 2008 Jul;86(1):137-47

Department of Otolaryngology, Washington University School of Medicine and John Cochran VA Medical Center, St. Louis, MO, USA.

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http://dx.doi.org/10.1097/TP.0b013e31817b8e4bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140461PMC
July 2008

Strategies to cure experimental autoimmune colitis using antigen-specific Foxp3+ regulatory T cells.

Gastroenterology 2008 Jun 13;134(7):2171-4. Epub 2008 May 13.

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http://dx.doi.org/10.1053/j.gastro.2008.04.030DOI Listing
June 2008

Regulatory T cell expression of herpesvirus entry mediator suppresses the function of B and T lymphocyte attenuator-positive effector T cells.

J Immunol 2008 May;180(10):6649-55

Department of Pathology and Laboratory Medicine, Joseph Stokes Jr Research Institute and Biesecker Pediatric Liver Center, The Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.4049/jimmunol.180.10.6649DOI Listing
May 2008

Resistance of Foxp3+ regulatory T cells to Nur77-induced apoptosis promotes allograft survival.

PLoS One 2008 May 28;3(5):e2321. Epub 2008 May 28.

Department of Pathology and Laboratory Medicine, Stokes Research Institute and Biesecker Pediatric Liver Center, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0002321PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386419PMC
May 2008

Primary coenzyme Q deficiency in Pdss2 mutant mice causes isolated renal disease.

PLoS Genet 2008 Apr 25;4(4):e1000061. Epub 2008 Apr 25.

Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1000061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291193PMC
April 2008

Deacetylase inhibition promotes the generation and function of regulatory T cells.

Nat Med 2007 Nov 7;13(11):1299-307. Epub 2007 Oct 7.

Division of Transplantation Immunology, Department of Pathology and Laboratory Medicine and Biesecker Center for Studies of Pediatric Liver Diseases, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104-4318, USA.

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http://dx.doi.org/10.1038/nm1652DOI Listing
November 2007

Negative and positive co-signaling with anti-BTLA (PJ196) and CTLA4Ig prolongs islet allograft survival.

Transplantation 2007 Nov;84(10):1368-72

The Surgical Medical Research Institute, Department of Surgery, Faculty of Medicine, The University of Alberta, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1097/01.tp.0000289995.70390.20DOI Listing
November 2007

Biochemistry and therapeutic implications of mechanisms involved in FOXP3 activity in immune suppression.

Curr Opin Immunol 2007 Oct 20;19(5):583-8. Epub 2007 Aug 20.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, 252 John Morgan Building, 36th and Hamilton Walk, Philadelphia, PA 19104-6082, USA.

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http://dx.doi.org/10.1016/j.coi.2007.07.006DOI Listing
October 2007

Histone deacetylase inhibitors and transplantation.

Curr Opin Immunol 2007 Oct 24;19(5):589-95. Epub 2007 Aug 24.

Division of Transplant Immunology, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104-4318, USA.

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http://dx.doi.org/10.1016/j.coi.2007.07.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693068PMC
October 2007

Programmed cell death 1 (PD-1) and its ligand PD-L1 are required for allograft tolerance.

Eur J Immunol 2007 Oct;37(10):2983-90

Department of Pathology and Laboratory Medicine, Joseph Stokes Jr Research Institute and Biesecker Pediatric Liver Center, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA 19104-4318, USA.

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http://dx.doi.org/10.1002/eji.200737583DOI Listing
October 2007

Delayed and deficient dermal maturation in mice lacking the CXCR3 ELR-negative CXC chemokine receptor.

Am J Pathol 2007 Aug 28;171(2):484-95. Epub 2007 Jun 28.

Department of Pathology, University of Pittsburgh and Pittsburgh VAMC, Pittsburgh, Pennsylvania 15261, USA.

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http://dx.doi.org/10.2353/ajpath.2007.061092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1934531PMC
August 2007

Regulating regulatory T cells to achieve transplant tolerance.

Hepatobiliary Pancreat Dis Int 2007 Aug;6(4):348-57

Division of Transplantation Immunology, Department of Pathology and Laboratory Medicine, Joseph Stokes, Jr., Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.

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August 2007

Selective targeting of the LIGHT-HVEM costimulatory system for the treatment of graft-versus-host disease.

Blood 2007 May 19;109(9):4097-104. Epub 2006 Dec 19.

Department of Molecular Biology and Biochemistry, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1182/blood-2006-09-047332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1874563PMC
May 2007

FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression.

Proc Natl Acad Sci U S A 2007 Mar 7;104(11):4571-6. Epub 2007 Mar 7.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, 36th and Hamilton Walk, Philadelphia, PA 19104-6082, USA.

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http://dx.doi.org/10.1073/pnas.0700298104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1838642PMC
March 2007

Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylation.

J Biol Chem 2006 Dec 6;281(48):36828-34. Epub 2006 Oct 6.

Joseph Stokes, Jr. Research Institute, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.

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http://www.jbc.org/content/281/48/36828.full.pdf
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http://dx.doi.org/10.1074/jbc.M608848200DOI Listing
December 2006

The cyclin-dependent kinase inhibitor p27kip1 is required for transplantation tolerance induced by costimulatory blockade.

J Immunol 2006 Oct;177(8):5169-76

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.4049/jimmunol.177.8.5169DOI Listing
October 2006

PTEN inhibits IL-2 receptor-mediated expansion of CD4+ CD25+ Tregs.

J Clin Invest 2006 Sep 17;116(9):2521-31. Epub 2006 Aug 17.

Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6144, USA.

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http://www.jci.org/cgi/doi/10.1172/JCI28057
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http://dx.doi.org/10.1172/JCI28057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1550279PMC
September 2006

Safety and efficacy of a calcineurin inhibitor avoidance regimen in pediatric renal transplantation.

J Am Soc Nephrol 2006 Jun 10;17(6):1735-45. Epub 2006 May 10.

Transplantation Research Center, Children's Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1681/ASN.2006010049DOI Listing
June 2006

Coinhibitory T-cell signaling in islet allograft rejection and tolerance.

Cell Transplant 2006 ;15(2):105-19

Department of Surgery, Faculty of Medicine, University of Alberta, Edmonton, AB, Canada.

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http://dx.doi.org/10.3727/000000006783982160DOI Listing
June 2006

CXCR3+CD4+ T cells mediate innate immune function in the pathophysiology of liver ischemia/reperfusion injury.

J Immunol 2006 May;176(10):6313-22

Department of Surgery, Division of Liver and Pancreas Transplantation, The Dumont-University of California Los Angeles (UCLA) Transplant Center, David Geffen School of Medicine, UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.4049/jimmunol.176.10.6313DOI Listing
May 2006

Differential expression of profibrotic and growth factors in chronic allograft nephropathy.

Transplantation 2006 Feb;81(3):342-9

Pediatric Nephrology, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1097/01.tp.0000195773.24217.95DOI Listing
February 2006

Costimulation blockade of both inducible costimulator and CD40 ligand induces dominant tolerance to islet allografts and prevents spontaneous autoimmune diabetes in the NOD mouse.

Diabetes 2006 Jan;55(1):27-33

Roberts Centre, 2000 College Plaza, University of Alberta, 2000 College Plaza, 8215 112 St., Edmonton, Alberta, Canada T6G 2C8.

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January 2006