Wayne Tilley

Wayne Tilley

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Wayne Tilley

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Cyclin-Dependent Kinase 2 Inhibitors in Cancer Therapy: An Update.

J Med Chem 2019 May 20;62(9):4233-4251. Epub 2018 Dec 20.

Centre for Drug Discovery and Development , University of South Australia Cancer Research Institute , Adelaide , SA 5000 , Australia.

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http://dx.doi.org/10.1021/acs.jmedchem.8b01469DOI Listing
May 2019

Androgen Receptor Signalling Promotes a Luminal Phenotype in Mammary Epithelial Cells.

J Mammary Gland Biol Neoplasia 2019 Mar 12;24(1):99-108. Epub 2018 Aug 12.

Dame Roma Mitchell Cancer Research Laboratories, Faculty of Health & Medical Sciences, The University of Adelaide, Adelaide, SA, 5005, Australia.

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http://dx.doi.org/10.1007/s10911-018-9406-2DOI Listing
March 2019

Author Correction: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.

Authors:
Fredrick R Schumacher Ali Amin Al Olama Sonja I Berndt Sara Benlloch Mahbubl Ahmed Edward J Saunders Tokhir Dadaev Daniel Leongamornlert Ezequiel Anokian Clara Cieza-Borrella Chee Goh Mark N Brook Xin Sheng Laura Fachal Joe Dennis Jonathan Tyrer Kenneth Muir Artitaya Lophatananon Victoria L Stevens Susan M Gapstur Brian D Carter Catherine M Tangen Phyllis J Goodman Ian M Thompson Jyotsna Batra Suzanne Chambers Leire Moya Judith Clements Lisa Horvath Wayne Tilley Gail P Risbridger Henrik Gronberg Markus Aly Tobias Nordström Paul Pharoah Nora Pashayan Johanna Schleutker Teuvo L J Tammela Csilla Sipeky Anssi Auvinen Demetrius Albanes Stephanie Weinstein Alicja Wolk Niclas Håkansson Catharine M L West Alison M Dunning Neil Burnet Lorelei A Mucci Edward Giovannucci Gerald L Andriole Olivier Cussenot Géraldine Cancel-Tassin Stella Koutros Laura E Beane Freeman Karina Dalsgaard Sorensen Torben Falck Orntoft Michael Borre Lovise Maehle Eli Marie Grindedal David E Neal Jenny L Donovan Freddie C Hamdy Richard M Martin Ruth C Travis Tim J Key Robert J Hamilton Neil E Fleshner Antonio Finelli Sue Ann Ingles Mariana C Stern Barry S Rosenstein Sarah L Kerns Harry Ostrer Yong-Jie Lu Hong-Wei Zhang Ninghan Feng Xueying Mao Xin Guo Guomin Wang Zan Sun Graham G Giles Melissa C Southey Robert J MacInnis Liesel M FitzGerald Adam S Kibel Bettina F Drake Ana Vega Antonio Gómez-Caamaño Robert Szulkin Martin Eklund Manolis Kogevinas Javier Llorca Gemma Castaño-Vinyals Kathryn L Penney Meir Stampfer Jong Y Park Thomas A Sellers Hui-Yi Lin Janet L Stanford Cezary Cybulski Dominika Wokolorczyk Jan Lubinski Elaine A Ostrander Milan S Geybels Børge G Nordestgaard Sune F Nielsen Maren Weischer Rasmus Bisbjerg Martin Andreas Røder Peter Iversen Hermann Brenner Katarina Cuk Bernd Holleczek Christiane Maier Manuel Luedeke Thomas Schnoeller Jeri Kim Christopher J Logothetis Esther M John Manuel R Teixeira Paula Paulo Marta Cardoso Susan L Neuhausen Linda Steele Yuan Chun Ding Kim De Ruyck Gert De Meerleer Piet Ost Azad Razack Jasmine Lim Soo-Hwang Teo Daniel W Lin Lisa F Newcomb Davor Lessel Marija Gamulin Tomislav Kulis Radka Kaneva Nawaid Usmani Sandeep Singhal Chavdar Slavov Vanio Mitev Matthew Parliament Frank Claessens Steven Joniau Thomas Van den Broeck Samantha Larkin Paul A Townsend Claire Aukim-Hastie Manuela Gago-Dominguez Jose Esteban Castelao Maria Elena Martinez Monique J Roobol Guido Jenster Ron H N van Schaik Florence Menegaux Thérèse Truong Yves Akoli Koudou Jianfeng Xu Kay-Tee Khaw Lisa Cannon-Albright Hardev Pandha Agnieszka Michael Stephen N Thibodeau Shannon K McDonnell Daniel J Schaid Sara Lindstrom Constance Turman Jing Ma David J Hunter Elio Riboli Afshan Siddiq Federico Canzian Laurence N Kolonel Loic Le Marchand Robert N Hoover Mitchell J Machiela Zuxi Cui Peter Kraft Christopher I Amos David V Conti Douglas F Easton Fredrik Wiklund Stephen J Chanock Brian E Henderson Zsofia Kote-Jarai Christopher A Haiman Rosalind A Eeles

Nat Genet 2019 02;51(2):363

Institute of Cancer Research, London, UK.

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http://www.nature.com/articles/s41588-018-0330-6
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http://dx.doi.org/10.1038/s41588-018-0330-6DOI Listing
February 2019

Interplay between the androgen receptor signalling axis and microRNAs in prostate cancer.

Endocr Relat Cancer 2019 Feb 1. Epub 2019 Feb 1.

L Selth, Medicine, University of Adelaide, Adelaide, 5005, Australia.

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http://dx.doi.org/10.1530/ERC-18-0571DOI Listing
February 2019

New Opportunities for Targeting the Androgen Receptor in Prostate Cancer.

Cold Spring Harb Perspect Med 2018 12 3;8(12). Epub 2018 Dec 3.

Adelaide Medical School and Freemasons Foundation Centre for Men's Health, University of Adelaide, Adelaide SA 5005, Australia.

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http://perspectivesinmedicine.cshlp.org/lookup/doi/10.1101/c
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http://dx.doi.org/10.1101/cshperspect.a030478DOI Listing
December 2018

Patient-derived Models of Abiraterone- and Enzalutamide-resistant Prostate Cancer Reveal Sensitivity to Ribosome-directed Therapy.

Eur Urol 2018 11 23;74(5):562-572. Epub 2018 Jul 23.

Monash Partners Comprehensive Cancer Consortium, Monash Biomedicine Discovery Institute Cancer Program, Prostate Cancer Research Group, Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, Australia; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia; Melbourne Urological Research Alliance (MURAL), Melbourne, VIC, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2018.06.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351078PMC
November 2018

Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.

Authors:
Fredrick R Schumacher Ali Amin Al Olama Sonja I Berndt Sara Benlloch Mahbubl Ahmed Edward J Saunders Tokhir Dadaev Daniel Leongamornlert Ezequiel Anokian Clara Cieza-Borrella Chee Goh Mark N Brook Xin Sheng Laura Fachal Joe Dennis Jonathan Tyrer Kenneth Muir Artitaya Lophatananon Victoria L Stevens Susan M Gapstur Brian D Carter Catherine M Tangen Phyllis J Goodman Ian M Thompson Jyotsna Batra Suzanne Chambers Leire Moya Judith Clements Lisa Horvath Wayne Tilley Gail P Risbridger Henrik Gronberg Markus Aly Tobias Nordström Paul Pharoah Nora Pashayan Johanna Schleutker Teuvo L J Tammela Csilla Sipeky Anssi Auvinen Demetrius Albanes Stephanie Weinstein Alicja Wolk Niclas Håkansson Catharine M L West Alison M Dunning Neil Burnet Lorelei A Mucci Edward Giovannucci Gerald L Andriole Olivier Cussenot Géraldine Cancel-Tassin Stella Koutros Laura E Beane Freeman Karina Dalsgaard Sorensen Torben Falck Orntoft Michael Borre Lovise Maehle Eli Marie Grindedal David E Neal Jenny L Donovan Freddie C Hamdy Richard M Martin Ruth C Travis Tim J Key Robert J Hamilton Neil E Fleshner Antonio Finelli Sue Ann Ingles Mariana C Stern Barry S Rosenstein Sarah L Kerns Harry Ostrer Yong-Jie Lu Hong-Wei Zhang Ninghan Feng Xueying Mao Xin Guo Guomin Wang Zan Sun Graham G Giles Melissa C Southey Robert J MacInnis Liesel M FitzGerald Adam S Kibel Bettina F Drake Ana Vega Antonio Gómez-Caamaño Robert Szulkin Martin Eklund Manolis Kogevinas Javier Llorca Gemma Castaño-Vinyals Kathryn L Penney Meir Stampfer Jong Y Park Thomas A Sellers Hui-Yi Lin Janet L Stanford Cezary Cybulski Dominika Wokolorczyk Jan Lubinski Elaine A Ostrander Milan S Geybels Børge G Nordestgaard Sune F Nielsen Maren Weischer Rasmus Bisbjerg Martin Andreas Røder Peter Iversen Hermann Brenner Katarina Cuk Bernd Holleczek Christiane Maier Manuel Luedeke Thomas Schnoeller Jeri Kim Christopher J Logothetis Esther M John Manuel R Teixeira Paula Paulo Marta Cardoso Susan L Neuhausen Linda Steele Yuan Chun Ding Kim De Ruyck Gert De Meerleer Piet Ost Azad Razack Jasmine Lim Soo-Hwang Teo Daniel W Lin Lisa F Newcomb Davor Lessel Marija Gamulin Tomislav Kulis Radka Kaneva Nawaid Usmani Sandeep Singhal Chavdar Slavov Vanio Mitev Matthew Parliament Frank Claessens Steven Joniau Thomas Van den Broeck Samantha Larkin Paul A Townsend Claire Aukim-Hastie Manuela Gago-Dominguez Jose Esteban Castelao Maria Elena Martinez Monique J Roobol Guido Jenster Ron H N van Schaik Florence Menegaux Thérèse Truong Yves Akoli Koudou Jianfeng Xu Kay-Tee Khaw Lisa Cannon-Albright Hardev Pandha Agnieszka Michael Stephen N Thibodeau Shannon K McDonnell Daniel J Schaid Sara Lindstrom Constance Turman Jing Ma David J Hunter Elio Riboli Afshan Siddiq Federico Canzian Laurence N Kolonel Loic Le Marchand Robert N Hoover Mitchell J Machiela Zuxi Cui Peter Kraft Christopher I Amos David V Conti Douglas F Easton Fredrik Wiklund Stephen J Chanock Brian E Henderson Zsofia Kote-Jarai Christopher A Haiman Rosalind A Eeles

Nat Genet 2018 07 11;50(7):928-936. Epub 2018 Jun 11.

Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1038/s41588-018-0142-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6568012PMC
July 2018

Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants.

Authors:
Tokhir Dadaev Edward J Saunders Paul J Newcombe Ezequiel Anokian Daniel A Leongamornlert Mark N Brook Clara Cieza-Borrella Martina Mijuskovic Sarah Wakerell Ali Amin Al Olama Fredrick R Schumacher Sonja I Berndt Sara Benlloch Mahbubl Ahmed Chee Goh Xin Sheng Zhuo Zhang Kenneth Muir Koveela Govindasami Artitaya Lophatananon Victoria L Stevens Susan M Gapstur Brian D Carter Catherine M Tangen Phyllis Goodman Ian M Thompson Jyotsna Batra Suzanne Chambers Leire Moya Judith Clements Lisa Horvath Wayne Tilley Gail Risbridger Henrik Gronberg Markus Aly Tobias Nordström Paul Pharoah Nora Pashayan Johanna Schleutker Teuvo L J Tammela Csilla Sipeky Anssi Auvinen Demetrius Albanes Stephanie Weinstein Alicja Wolk Niclas Hakansson Catharine West Alison M Dunning Neil Burnet Lorelei Mucci Edward Giovannucci Gerald Andriole Olivier Cussenot Géraldine Cancel-Tassin Stella Koutros Laura E Beane Freeman Karina Dalsgaard Sorensen Torben Falck Orntoft Michael Borre Lovise Maehle Eli Marie Grindedal David E Neal Jenny L Donovan Freddie C Hamdy Richard M Martin Ruth C Travis Tim J Key Robert J Hamilton Neil E Fleshner Antonio Finelli Sue Ann Ingles Mariana C Stern Barry Rosenstein Sarah Kerns Harry Ostrer Yong-Jie Lu Hong-Wei Zhang Ninghan Feng Xueying Mao Xin Guo Guomin Wang Zan Sun Graham G Giles Melissa C Southey Robert J MacInnis Liesel M FitzGerald Adam S Kibel Bettina F Drake Ana Vega Antonio Gómez-Caamaño Laura Fachal Robert Szulkin Martin Eklund Manolis Kogevinas Javier Llorca Gemma Castaño-Vinyals Kathryn L Penney Meir Stampfer Jong Y Park Thomas A Sellers Hui-Yi Lin Janet L Stanford Cezary Cybulski Dominika Wokolorczyk Jan Lubinski Elaine A Ostrander Milan S Geybels Børge G Nordestgaard Sune F Nielsen Maren Weisher Rasmus Bisbjerg Martin Andreas Røder Peter Iversen Hermann Brenner Katarina Cuk Bernd Holleczek Christiane Maier Manuel Luedeke Thomas Schnoeller Jeri Kim Christopher J Logothetis Esther M John Manuel R Teixeira Paula Paulo Marta Cardoso Susan L Neuhausen Linda Steele Yuan Chun Ding Kim De Ruyck Gert De Meerleer Piet Ost Azad Razack Jasmine Lim Soo-Hwang Teo Daniel W Lin Lisa F Newcomb Davor Lessel Marija Gamulin Tomislav Kulis Radka Kaneva Nawaid Usmani Chavdar Slavov Vanio Mitev Matthew Parliament Sandeep Singhal Frank Claessens Steven Joniau Thomas Van den Broeck Samantha Larkin Paul A Townsend Claire Aukim-Hastie Manuela Gago-Dominguez Jose Esteban Castelao Maria Elena Martinez Monique J Roobol Guido Jenster Ron H N van Schaik Florence Menegaux Thérèse Truong Yves Akoli Koudou Jianfeng Xu Kay-Tee Khaw Lisa Cannon-Albright Hardev Pandha Agnieszka Michael Andrzej Kierzek Stephen N Thibodeau Shannon K McDonnell Daniel J Schaid Sara Lindstrom Constance Turman Jing Ma David J Hunter Elio Riboli Afshan Siddiq Federico Canzian Laurence N Kolonel Loic Le Marchand Robert N Hoover Mitchell J Machiela Peter Kraft Matthew Freedman Fredrik Wiklund Stephen Chanock Brian E Henderson Douglas F Easton Christopher A Haiman Rosalind A Eeles David V Conti Zsofia Kote-Jarai

Nat Commun 2018 06 11;9(1):2256. Epub 2018 Jun 11.

The Institute of Cancer Research, London, SW7 3RP, UK.

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http://dx.doi.org/10.1038/s41467-018-04109-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995836PMC
June 2018

Disrupting Androgen Receptor Signaling Induces Snail-Mediated Epithelial-Mesenchymal Plasticity in Prostate Cancer.

Cancer Res 2017 06 16;77(11):3101-3112. Epub 2017 Mar 16.

Department of Urology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-2169DOI Listing
June 2017

Deciphering the divergent roles of progestogens in breast cancer.

Nat Rev Cancer 2017 01 25;17(1):54-64. Epub 2016 Nov 25.

Dame Roma Mitchell Cancer Research Laboratories, Hanson Institute and School of Medicine, University of Adelaide, Adelaide SA 5005, Australia.

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http://dx.doi.org/10.1038/nrc.2016.116DOI Listing
January 2017

Pushing estrogen receptor around in breast cancer.

Endocr Relat Cancer 2016 12 11;23(12):T227-T241. Epub 2016 Oct 11.

Institute of Translational MedicineUniversity of Liverpool, Clatterbridge Cancer Centre, NHS Foundation Trust, and Royal Liverpool University Hospital, Liverpool, Merseyside, UK

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http://dx.doi.org/10.1530/ERC-16-0427DOI Listing
December 2016

Androgen receptor signaling in castration-resistant prostate cancer: a lesson in persistence.

Endocr Relat Cancer 2016 12 31;23(12):T179-T197. Epub 2016 Oct 31.

Dame Roma Mitchell Cancer Research LaboratoriesSchool of Medicine, The University of Adelaide, Adelaide, South Australia, Australia

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http://dx.doi.org/10.1530/ERC-16-0422DOI Listing
December 2016

Novel twists in hormone-mediated carcinogenesis.

Authors:
Wayne D Tilley

Endocr Relat Cancer 2016 12;23(12):E9-E12

Dame Roma Mitchell Cancer Research LaboratoriesSchool of Medicine, Faculty of Health Sciences, The University of Adelaide, Adelaide, Australia

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http://dx.doi.org/10.1530/ERC-16-0466DOI Listing
December 2016

Androgen and Estrogen Receptors in Breast Cancer Coregulate Human UDP-Glucuronosyltransferases 2B15 and 2B17.

Cancer Res 2016 10 5;76(19):5881-5893. Epub 2016 Aug 5.

Dame Roma Mitchell Cancer Research Laboratories, School of Medicine, The University of Adelaide, South Australia, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-3372DOI Listing
October 2016

Renewed interest in the progesterone receptor in breast cancer.

Br J Cancer 2016 10 22;115(8):909-911. Epub 2016 Sep 22.

Dame Roma Mitchell Cancer Research Laboratories, School of Medicine, University of Adelaide, Adelaide, SA, Australia.

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http://dx.doi.org/10.1038/bjc.2016.303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061913PMC
October 2016

Small Glutamine-Rich Tetratricopeptide Repeat-Containing Protein Alpha (SGTA) Ablation Limits Offspring Viability and Growth in Mice.

Sci Rep 2016 06 30;6:28950. Epub 2016 Jun 30.

Adelaide Prostate Cancer Research Centre and Dame Roma Mitchell Cancer Research Laboratories, Faculty of Health Sciences, University of Adelaide, Adelaide, Australia.

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http://dx.doi.org/10.1038/srep28950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928056PMC
June 2016

Choline Kinase Alpha as an Androgen Receptor Chaperone and Prostate Cancer Therapeutic Target.

J Natl Cancer Inst 2016 May 11;108(5). Epub 2015 Dec 11.

Affiliations of authors:Cancer Research UK Cambridge Institute, University of Cambridge , Cambridge, UK (MA, CEM, NP, HIZ, AQ, AB, SM, BM, CE, SL, SW, VRZ, GS, RR, HM, AGL, CD, CT, AL, RS, JY, RS, JSC, JRG, ST, DEN); School of Medical Sciences, University of Aberdeen , Aberdeen, UK (FO, IJM); Department of Pathology, Addenbrooke's Hospital , Cambridge, UK (AYW, NS); Institute of Human Genetics, Jena University Hospital , Jena , Germany (ME, KL, WH, AB); Dame Roma Mitchell Cancer Research Laboratories, School of Medicine, Faculty of Health Sciences, University of Adelaide , Australia (LAS, WDT); Freemasons Foundation Centre for Men's Health, School of Medicine, Faculty of Health Sciences, University of Adelaide , Australia (LAS, WDT); Diatherix , Huntsville, AL (EG); Masonic Cancer Center, University of Minnesota , Minneapolis, MN (SMD); The Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia , Vancouver BC , Canada (PSR); Centre for Molecular Medicine Norway, Nordic EMBL Partnership, University of Oslo and Oslo University Hospital , Oslo , Norway (IGM); Department of Cancer Prevention, Institute of Cancer Research and Department of Urology, Oslo University Hospital , Oslo , Norway (IGM); Prostate Cancer UK/Movember Centre of Excellence, Queens University , Belfast , UK (IGM); Department of Oncology, Addenbrooke's Hospital , Cambridge, UK (MA, DEN).

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http://jnci.oxfordjournals.org/content/108/5/djv371.full.pdf
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http://jnci.oxfordjournals.org/lookup/doi/10.1093/jnci/djv37
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http://dx.doi.org/10.1093/jnci/djv371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849803PMC
May 2016

Erratum to: IκBα mediates prostate cancer cell death induced by combinatorial targeting of the androgen receptor.

BMC Cancer 2016 Mar 3;16:177. Epub 2016 Mar 3.

Dame Roma Mitchell Cancer Research Laboratories, Adelaide Prostate Cancer Research Centre and Freemason's Foundation Centre for Men's Health, School of Medicine, University of Adelaide and Hanson Institute, Adelaide, SA, 5005, Australia.

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http://dx.doi.org/10.1186/s12885-016-2215-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776442PMC
March 2016

IκBα mediates prostate cancer cell death induced by combinatorial targeting of the androgen receptor.

BMC Cancer 2016 Feb 23;16:141. Epub 2016 Feb 23.

Dame Roma Mitchell Cancer Research Laboratories, Adelaide Prostate Cancer Research Centre and Freemason's Foundation Centre for Men's Health, School of Medicine, University of Adelaide and Hanson Institute, Adelaide, SA, 5005, Australia.

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http://dx.doi.org/10.1186/s12885-016-2188-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785192PMC
February 2016

Regulators of genetic risk of breast cancer identified by integrative network analysis.

Nat Genet 2016 Jan 30;48(1):12-21. Epub 2015 Nov 30.

Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.

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http://dx.doi.org/10.1038/ng.3458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697365PMC
January 2016

Co-targeting AR and HSP90 suppresses prostate cancer cell growth and prevents resistance mechanisms.

Endocr Relat Cancer 2015 Oct 17;22(5):805-18. Epub 2015 Jul 17.

Dame Roma Mitchell Cancer Research Laboratories Adelaide Prostate Cancer Research Centre and Freemason's Foundation Centre for Men's Health, School of Medicine, University of Adelaide, Adelaide, Australia South Australian Health and Medical Research Institute PO Box 11060, Adelaide, South Australia 5001, Australia Dame Roma Mitchell Cancer Research Laboratories Adelaide Prostate Cancer Research Centre and Freemason's Foundation Centre for Men's Health, School of Medicine, University of Adelaide, Adelaide, Australia South Australian Health and Medical Research Institute PO Box 11060, Adelaide, South Australia 5001, Australia

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http://dx.doi.org/10.1530/ERC-14-0541DOI Listing
October 2015

Targeting chromatin binding regulation of constitutively active AR variants to overcome prostate cancer resistance to endocrine-based therapies.

Nucleic Acids Res 2015 Jul 23;43(12):5880-97. Epub 2015 Apr 23.

Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55905, USA Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55905, USA

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http://dx.doi.org/10.1093/nar/gkv262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499120PMC
July 2015

Hormone-sensing mammary epithelial progenitors: emerging identity and hormonal regulation.

J Mammary Gland Biol Neoplasia 2015 Jun 21;20(1-2):75-91. Epub 2015 Sep 21.

Dame Roma Mitchell Cancer Research Laboratories (DRMCRL), School of Medicine, Faculty of Health Sciences, The University of Adelaide, Adelaide, SA, 5005, Australia.

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http://dx.doi.org/10.1007/s10911-015-9344-1DOI Listing
June 2015

Expression and localisation of c-kit and KITL in the adult human ovary.

J Ovarian Res 2015 May 26;8:31. Epub 2015 May 26.

Robinson Research Institute, School of Paediatrics and Reproductive Health, Adelaide, South Australia, Australia.

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http://dx.doi.org/10.1186/s13048-015-0159-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460643PMC
May 2015

Mouse GDF9 decreases KITL gene expression in human granulosa cells.

Endocrine 2015 Mar 2;48(2):686-95. Epub 2014 Jul 2.

School of Paediatrics and Reproductive Health, Robinson Research Institute, University of Adelaide, Adelaide, SA, 5005, Australia,

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http://dx.doi.org/10.1007/s12020-014-0335-6DOI Listing
March 2015

Epithelial plasticity in prostate cancer: principles and clinical perspectives.

Trends Mol Med 2014 Nov 25;20(11):643-51. Epub 2014 Sep 25.

Dame Roma Mitchell Cancer Research Laboratories and Adelaide Prostate Cancer Research Centre, The University of Adelaide, South Australia, Australia; Freemasons Foundation Centre for Men's Health, The University of Adelaide, South Australia, Australia; Discipline of Medicine, The University of Adelaide, South Australia, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2014.09.004DOI Listing
November 2014

Estrogen receptor beta in prostate cancer: friend or foe?

Endocr Relat Cancer 2014 Aug 8;21(4):T219-34. Epub 2014 Jan 8.

Cancer Research UKCambridge Institute, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UKDepartment of UrologyAddenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UKDame Roma Mitchell Cancer Research LaboratoriesFaculty of Health Sciences, School of Medicine, The University of Adelaide, Level 4, Hanson Institute Building, DX Number 650 801, Adelaide, South Australia 5000, AustraliaDepartment of OncologyUniversity of Cambridge, Cambridge CB2 2QQ, UKCancer Research UKCambridge Institute, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UKDepartment of UrologyAddenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UKDame Roma Mitchell Cancer Research LaboratoriesFaculty of Health Sciences, School of Medicine, The University of Adelaide, Level 4, Hanson Institute Building, DX Number 650 801, Adelaide, South Australia 5000, AustraliaDepartment of OncologyUniversity of Cambridge, Cambridge CB2 2QQ, UK.

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http://dx.doi.org/10.1530/ERC-13-0508DOI Listing
August 2014

Human seminal fluid as a source of prostate cancer-specific microRNA biomarkers.

Endocr Relat Cancer 2014 Aug 23;21(4):L17-21. Epub 2014 May 23.

Dame Roma Mitchell Cancer Research Laboratories and Adelaide Prostate Cancer Research CentreSchool of Medicine, The University of AdelaideLevel 4 Hanson Institute Building, DX Number 650 801, Adelaide, South Australia, SA 5005AustraliaFreemasons Foundation Centre for Men's Health, The University of Adelaide Adelaide, South AustraliaAustraliaRoyal Brisbane Hospital, University of Queensland Centre for Clinical ResearchLevel 6, Building 71/918, Herston, Brisbane, Queensland, QLD 4006AustraliaDepartment of UrologyRoyal Brisbane and Women's HospitalBrisbane, QueenslandAustraliaQueensland Institute of Medical ResearchHerston, Brisbane, QueenslandAustraliaSchool of Population Health, The University of QueenslandBrisbane, QueenslandAustraliaDepartment of EndocrinologyPrincess Alexandra HospitalBrisbane, QueenslandAustraliaDame Roma Mitchell Cancer Research Laboratories and Adelaide Prostate Cancer Research CentreSchool of Medicine, The University of AdelaideLevel 4 Hanson Institute Building, DX Number 650 801, Adelaide, South Australia, SA 5005AustraliaFreemasons Foundation Centre for Men's Health, The University of Adelaide Adelaide, South AustraliaAustraliaRoyal Brisbane Hospital, University of Queensland Centre for Clinical ResearchLevel 6, Building 71/918, Herston, Brisbane, Queensland, QLD 4006AustraliaDepartment of UrologyRoyal Brisbane and Women's HospitalBrisbane, QueenslandAustraliaQueensland Institute of Medical ResearchHerston, Brisbane, QueenslandAustraliaSchool of Population Health, The University of QueenslandBrisbane, QueenslandAustraliaDepartment of EndocrinologyPrincess Alexandra HospitalBrisbane, QueenslandAustralia

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http://dx.doi.org/10.1530/ERC-14-0234DOI Listing
August 2014

Complexities of androgen receptor signalling in breast cancer.

Endocr Relat Cancer 2014 Aug 20;21(4):T161-81. Epub 2014 Jun 20.

Department of PathologyTohoku University School of Medicine, Miyagi, Sendai, JapanDame Roma Mitchell Cancer Research LaboratoriesDiscipline of Medicine, The University of Adelaide and Hanson Institute, DX 650801, Adelaide, South Australia 5005, Australia

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http://dx.doi.org/10.1530/ERC-14-0243DOI Listing
August 2014

Bringing androgens up a NOTCH in breast cancer.

Endocr Relat Cancer 2014 Aug 7;21(4):T183-202. Epub 2014 Jul 7.

Dame Roma Mitchell Cancer Research Laboratories (DRMCRL)Faculty of Health Sciences, School of Medicine, The University of Adelaide, Adelaide, South Australia 5005, Australia.

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http://dx.doi.org/10.1530/ERC-14-0248DOI Listing
August 2014

Androgen signalling and steroid receptor crosstalk in endocrine cancers.

Endocr Relat Cancer 2014 Aug;21(4):E3-5

Molecular Endocrinology LaboratoryDepartment of Cellular and Molecular Medicine, KU Leuven, Herestraat 49, Campus GHB ON1, PO Box 901, 3000 Leuven, BelgiumDame Roma Mitchell Cancer Research LaboratoriesSchool of Medicine, University of Adelaide, Adelaide, South Australia 5000, Australia.

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http://dx.doi.org/10.1530/ERC-14-0274DOI Listing
August 2014

Tailoring peptidomimetics for targeting protein-protein interactions.

Mol Cancer Res 2014 Jul 18;12(7):967-78. Epub 2014 Mar 18.

Authors' Affiliations: Department of Urology, University of Texas Southwestern Medical Center, Dallas;

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http://mcr.aacrjournals.org/lookup/doi/10.1158/1541-7786.MCR
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http://dx.doi.org/10.1158/1541-7786.MCR-13-0611DOI Listing
July 2014

Breast cancer prognosis predicted by nuclear receptor-coregulator networks.

Mol Oncol 2014 Jul 4;8(5):998-1013. Epub 2014 Apr 4.

Westmead Millennium Institute, Sydney Medical School - Westmead, University of Sydney, NSW, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2014.03.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528526PMC
July 2014

PRMT2 and RORγ expression are associated with breast cancer survival outcomes.

Mol Endocrinol 2014 Jul 9;28(7):1166-85. Epub 2014 Jun 9.

Institute for Molecular Bioscience (T.G.O., P.B., J.G., N.E., S.G., D.H.D., G.E.O.M.) and School of Biomedical Science (A.G.S.), The University of Queensland, Brisbane, Queensland 4072, Australia; Institute of Health and Biomedical Innovation (E.D.), Queensland University of Technology, Translational Research Institute, Brisbane, Queensland 4102, Australia; Prince Henry's Institute of Medical Research (J.W.F., P.J.F., E.R.S.), Clayton, Victoria 3168, Australia; Dame Roma Mitchell Cancer Research Laboratory (W.D.T.), School of Medicine, The University of Adelaide, Adelaide 5005, South Australia, Australia; Western Australian Institute for Medical Research (P.J.L.), University of Western Australia, Perth, Western Australia 6009, Australia; Westmead Millennium Institute (C.L.C.), Sydney Medical School, Westmead, University of Sydney, New South Wales 2006, Australia; and Department of Molecular and Clinical Medicine/Wallenberg Laboratory (G.E.O.M.), University of Gothenburg, S-405 30 Gothenburg, Sweden.

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http://dx.doi.org/10.1210/me.2013-1403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414829PMC
July 2014

Identification of androgen receptor splice variant transcripts in breast cancer cell lines and human tissues.

Horm Cancer 2014 Apr 26;5(2):61-71. Epub 2014 Feb 26.

Department of Clinical Pharmacology, Flinders Medical Centre, Flinders University School of Medicine, Bedford Park, SA, 5042, Australia,

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http://dx.doi.org/10.1007/s12672-014-0171-4DOI Listing
April 2014

Antiandrogenic actions of medroxyprogesterone acetate on epithelial cells within normal human breast tissues cultured ex vivo.

Menopause 2014 Jan;21(1):79-88

From the 1Dame Roma Mitchell Cancer Research Laboratories, Hanson Institute, Discipline of Medicine, Faculty of Health Sciences, University of Adelaide, Adelaide, SA, Australia; and 2Emphron Informatics, Toowong, QLD, Australia.

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http://dx.doi.org/10.1097/GME.0b013e3182936ef4DOI Listing
January 2014

Peptidomimetic targeting of critical androgen receptor-coregulator interactions in prostate cancer.

Nat Commun 2013 ;4:1923

Department of Urology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA.

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http://dx.doi.org/10.1038/ncomms2912DOI Listing
December 2013

Identification of prostate cancer-associated microRNAs in circulation using a mouse model of disease.

Methods Mol Biol 2013 ;1024:235-46

Dame Roma Mitchell Cancer Research Laboratories, The University of Adelaide, Adelaide, SA, Australia.

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http://dx.doi.org/10.1007/978-1-62703-453-1_19DOI Listing
December 2013

Knockdown of the cochaperone SGTA results in the suppression of androgen and PI3K/Akt signaling and inhibition of prostate cancer cell proliferation.

Int J Cancer 2013 Dec 6;133(12):2812-23. Epub 2013 Jul 6.

Cancer Biology Group, Freemasons Foundation Centre for Men's Health, Basil Hetzel Institute for Translational Health Research, Department of Medicine, University of Adelaide, Adelaide, Australia.

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http://dx.doi.org/10.1002/ijc.28310DOI Listing
December 2013

SGTA: a new player in the molecular co-chaperone game.

Horm Cancer 2013 Dec 2;4(6):343-57. Epub 2013 Jul 2.

Adelaide Prostate Cancer Research Centre and Dame Roma Mitchell Cancer Research Laboratories, School of Medicine, Faculty of Health Sciences, The University of Adelaide, Level 4, Hanson Institute Building, DX Number 650 801, Adelaide, South Australia, 5000, Australia.

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http://dx.doi.org/10.1007/s12672-013-0151-0DOI Listing
December 2013

Ex vivo culture of human prostate tissue and drug development.

Nat Rev Urol 2013 Aug 11;10(8):483-7. Epub 2013 Jun 11.

Dame Roma Mitchell Cancer Research Laboratories and Adelaide Prostate Cancer Research Centre, University of Adelaide, SA 5000, Australia.

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http://dx.doi.org/10.1038/nrurol.2013.126DOI Listing
August 2013

Small glutamine-rich tetratricopeptide repeat-containing protein alpha is present in human ovaries but may not be differentially expressed in relation to polycystic ovary syndrome.

Fertil Steril 2013 Jun 20;99(7):2076-83.e1. Epub 2013 Feb 20.

Dame Roma Mitchell Cancer Research Laboratories, School of Medicine, University of Adelaide, Adelaide, South Australia, Australia.

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http://dx.doi.org/10.1016/j.fertnstert.2013.01.140DOI Listing
June 2013

Androgen receptor protein levels are significantly reduced in serous ovarian carcinomas compared with benign or borderline disease but are not altered by cancer stage or metastatic progression.

Horm Cancer 2013 Jun 27;4(3):154-64. Epub 2013 Feb 27.

Dame Roma Mitchell Cancer Research Laboratories, School of Medicine, Faculty of Health Sciences, Level 4, Hanson Institute Building, DX NUMBER 650 801, The University of Adelaide, Adelaide, SA, 5005, Australia.

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http://dx.doi.org/10.1007/s12672-013-0135-0DOI Listing
June 2013

Constitutively-active androgen receptor variants function independently of the HSP90 chaperone but do not confer resistance to HSP90 inhibitors.

Oncotarget 2013 May;4(5):691-704

Dame Roma Mitchell Cancer Research Laboratories and Adelaide Prostate Cancer Research Centre, University of Adelaide and Hanson Institute, Adelaide, South Australia, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742830PMC
http://dx.doi.org/10.18632/oncotarget.975DOI Listing
May 2013

Hsp90: still a viable target in prostate cancer.

Biochim Biophys Acta 2013 Apr 31;1835(2):211-8. Epub 2012 Dec 31.

Adelaide Prostate Cancer Research Centre, University of Adelaide, Adelaide, Australia.

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http://dx.doi.org/10.1016/j.bbcan.2012.12.005DOI Listing
April 2013

Characterization of the prostate cancer susceptibility gene KLF6 in human and mouse prostate cancers.

Prostate 2013 Jan 10;73(2):182-93. Epub 2012 Jul 10.

Dame Roma Mitchell Cancer Research Laboratories and Adelaide Prostate Cancer Research Centre, Discipline of Medicine, The University of Adelaide and Hanson Institute, Adelaide, Australia.

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http://dx.doi.org/10.1002/pros.22554DOI Listing
January 2013

Research resource: interplay between the genomic and transcriptional networks of androgen receptor and estrogen receptor α in luminal breast cancer cells.

Mol Endocrinol 2012 Nov 28;26(11):1941-52. Epub 2012 Sep 28.

Molecular Ageing Laboratory, The Freemasons Foundation Centre for Men’s Health, Basil Hetzel Institute for Translational Research, Australia.

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http://dx.doi.org/10.1210/me.2011-1314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487621PMC
November 2012

Subdomain structure of the co-chaperone SGTA and activity of its androgen receptor client.

J Mol Endocrinol 2012 Oct 25;49(2):57-68. Epub 2012 Jul 25.

Cancer Biology Group, Level 1 Basil Hetzel Institute for Translational Health Research, Freemasons Foundation Centre for Men's Health, Queen Elizabeth Hospital, University of Adelaide, 28 Woodville Road, Woodville South, Adelaide, South Australia 5011, Australia.

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http://dx.doi.org/10.1530/JME-11-0152DOI Listing
October 2012

Discovery of circulating microRNAs associated with human prostate cancer using a mouse model of disease.

Int J Cancer 2012 Aug 3;131(3):652-61. Epub 2011 Nov 3.

Dame Roma Mitchell Cancer Research Laboratories, Discipline of Medicine, University of Adelaide, Hanson Institute, Adelaide, South Australia, Australia.

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http://dx.doi.org/10.1002/ijc.26405DOI Listing
August 2012

A gene signature identified using a mouse model of androgen receptor-dependent prostate cancer predicts biochemical relapse in human disease.

Int J Cancer 2012 Aug 24;131(3):662-72. Epub 2012 Jan 24.

Dame Roma Mitchell Cancer Research Laboratories and Adelaide Prostate Cancer Research Centre, Discipline of Medicine, University of Adelaide, Hanson Institute, Adelaide, South Australia, Australia.

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http://dx.doi.org/10.1002/ijc.26414DOI Listing
August 2012

Circulating microRNAs: macro-utility as markers of prostate cancer?

Endocr Relat Cancer 2012 Aug 18;19(4):R99-R113. Epub 2012 Jun 18.

Dame Roma Mitchell Cancer Research Laboratories and Adelaide Prostate Cancer Research Centre, University of Adelaide and Hanson Institute, Adelaide 5000, Australia.

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http://dx.doi.org/10.1530/ERC-12-0010DOI Listing
August 2012

Protein arginine methyltransferase 6-dependent gene expression and splicing: association with breast cancer outcomes.

Endocr Relat Cancer 2012 Aug 22;19(4):509-26. Epub 2012 Jul 22.

Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.

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http://dx.doi.org/10.1530/ERC-12-0100DOI Listing
August 2012

An androgen receptor mutation in the MDA-MB-453 cell line model of molecular apocrine breast cancer compromises receptor activity.

Endocr Relat Cancer 2012 Aug 22;19(4):599-613. Epub 2012 Jul 22.

Dame Roma Mitchell Cancer Research Laboratories, Discipline of Medicine, The University of Adelaide and Hanson Institute, PO Box 14, Rundle Mall, Adelaide, South Australia 5000, Australia.

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http://dx.doi.org/10.1530/ERC-12-0065DOI Listing
August 2012

Therapeutic response to CDK4/6 inhibition in breast cancer defined by ex vivo analyses of human tumors.

Cell Cycle 2012 Jul 15;11(14):2756-61. Epub 2012 Jul 15.

Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA.

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http://dx.doi.org/10.4161/cc.21195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409015PMC
July 2012

Multiple nuclear receptor signaling pathways mediate the actions of synthetic progestins in target cells.

Mol Cell Endocrinol 2012 Jun 16;357(1-2):60-70. Epub 2011 Sep 16.

Dame Roma Mitchell Cancer Research Laboratories, School of Medicine, The University of Adelaide, Hanson Institute, Adelaide, South Australia 5000, Australia.

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http://dx.doi.org/10.1016/j.mce.2011.09.019DOI Listing
June 2012

GSTP1 DNA methylation and expression status is indicative of 5-aza-2'-deoxycytidine efficacy in human prostate cancer cells.

PLoS One 2011 28;6(9):e25634. Epub 2011 Sep 28.

Dame Roma Mitchell Cancer Research Laboratories, Discipline of Medicine, University of Adelaide, Hanson Institute, Adelaide, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0025634PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182253PMC
January 2012

Specific medical conditions associated with clinically significant depressive symptoms in men.

Soc Psychiatry Psychiatr Epidemiol 2011 Dec 26;46(12):1303-12. Epub 2010 Oct 26.

Royal Adelaide Hospital/Institute of Medical and Veterinary Science, South Australia Health, Government of South Australia, Adelaide, Australia.

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http://dx.doi.org/10.1007/s00127-010-0302-3DOI Listing
December 2011

Breast and prostate cancer: more similar than different.

Nat Rev Cancer 2010 Mar 11;10(3):205-12. Epub 2010 Feb 11.

Department of Anatomy & Developmental Biology, Monash University Clayton Campus, Melbourne 3800, Victoria, Australia.

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http://dx.doi.org/10.1038/nrc2795DOI Listing
March 2010

Circulating steroid hormone levels and risk of breast cancer for postmenopausal women.

Cancer Epidemiol Biomarkers Prev 2010 Feb 19;19(2):492-502. Epub 2010 Jan 19.

Cancer Epidemiology Centre, The Cancer Council Victoria, Victoria, Melbourne, Australia.

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http://dx.doi.org/10.1158/1055-9965.EPI-09-0532DOI Listing
February 2010

Serum testosterone bioassay evaluation in a large male cohort.

Clin Endocrinol (Oxf) 2010 Jan 28;72(1):87-98. Epub 2009 Mar 28.

Molecular Ageing Laboratory, The Freemasons Foundation Centre for Mens Health, The University of Adelaide, Adelaide, Australia.

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http://dx.doi.org/10.1111/j.1365-2265.2009.03595.xDOI Listing
January 2010

Finding the place of histone deacetylase inhibitors in prostate cancer therapy.

Expert Rev Clin Pharmacol 2009 Nov;2(6):619-30

Dame Roma Mitchell Cancer Research Laboratories, School of Medicine, University of Adelaide and Hanson Institute, Adelaide, SA 5000, Australia.

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http://dx.doi.org/10.1586/ecp.09.44DOI Listing
November 2009

Androgen receptor inhibits estrogen receptor-alpha activity and is prognostic in breast cancer.

Cancer Res 2009 Aug 28;69(15):6131-40. Epub 2009 Jul 28.

Dame Roma Mitchell Cancer Research Laboratories, Discipline of Medicine, University of Adelaide, Hanson Institute, Adelaide, South Australia, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-0452DOI Listing
August 2009

A novel androgen receptor amino terminal region reveals two classes of amino/carboxyl interaction-deficient variants with divergent capacity to activate responsive sites in chromatin.

Endocrinology 2009 Jun 12;150(6):2674-82. Epub 2009 Mar 12.

Molecular Ageing Laboratory, Freemasons Foundation Centre for Mens Health, Dame RomaMitchell Cancer Research Laboratories, University of Adelaide/Hanson Institute, Adelaide, Australia.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2008-1181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689802PMC
June 2009

Circulating steroid hormone concentrations in postmenopausal women in relation to body size and composition.

Breast Cancer Res Treat 2009 May 29;115(1):171-9. Epub 2008 May 29.

Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1007/s10549-008-0069-3DOI Listing
May 2009

Prostatic chondroitin sulfate is increased in patients with metastatic disease but does not predict survival outcome.

Prostate 2009 May;69(7):761-9

Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, University of Adelaide, Adelaide, SA, Australia.

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http://dx.doi.org/10.1002/pros.20926DOI Listing
May 2009

The dynamic and static modification of the epigenome by hormones: a role in the developmental origin of hormone related cancers.

Biochim Biophys Acta 2009 Apr 2;1795(2):104-9. Epub 2009 Jan 2.

Dame Roma Mitchell Cancer Research Laboratories, Discipline of Medicine, The University of Adelaide, Hanson Institute, PO Box 14 Rundle Mall, Adelaide, South Australia, 5000, Australia.

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http://dx.doi.org/10.1016/j.bbcan.2008.12.001DOI Listing
April 2009

The contribution of different androgen receptor domains to receptor dimerization and signaling.

Mol Endocrinol 2008 Nov 10;22(11):2373-82. Epub 2008 Jul 10.

Dame Roma Mitchell Cancer Research Laboratories, Discipline of Medicine, The University of Adelaide and Hanson Institute, PO Box 14, Rundle Mall, Adelaide, South Australia 5000, Australia.

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http://dx.doi.org/10.1210/me.2008-0017DOI Listing
November 2008

Elevated levels of HER-2/neu and androgen receptor in clinically localized prostate cancer identifies metastatic potential.

Prostate 2008 Jun;68(8):830-8

Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, University of Adelaide, Adelaide, Australia.

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http://doi.wiley.com/10.1002/pros.20747
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http://dx.doi.org/10.1002/pros.20747DOI Listing
June 2008

Antiproliferative actions of the synthetic androgen, mibolerone, in breast cancer cells are mediated by both androgen and progesterone receptors.

J Steroid Biochem Mol Biol 2008 Jun 20;110(3-5):236-43. Epub 2008 Apr 20.

Dame Roma Mitchell Cancer Research Laboratories, Discipline of Medicine, University of Adelaide and Hanson Institute, Adelaide, South Australia 5000, Australia.

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http://linkinghub.elsevier.com/retrieve/pii/S096007600800103
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http://dx.doi.org/10.1016/j.jsbmb.2007.10.014DOI Listing
June 2008