Publications by authors named "Wayne A Phillips"

78Publications

Control of Glucocorticoid Receptor Levels by PTEN Establishes a Failsafe Mechanism for Tumor Suppression.

Mol Cell 2020 Oct;80(2):279-295.e8

Cancer Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC 3800, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2020.09.027DOI Listing
October 2020

GRB7 is an oncogenic driver and potential therapeutic target in oesophageal adenocarcinoma.

J Pathol 2020 Nov 15;252(3):317-329. Epub 2020 Sep 15.

Division of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1002/path.5528DOI Listing
November 2020

Mouse Models for Exploring the Biological Consequences and Clinical Significance of Mutations.

Biomolecules 2019 04 23;9(4). Epub 2019 Apr 23.

Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.

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http://dx.doi.org/10.3390/biom9040158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523081PMC
April 2019

MEK Inhibition Induces Therapeutic Iodine Uptake in a Murine Model of Anaplastic Thyroid Cancer.

J Nucl Med 2019 07 21;60(7):917-923. Epub 2018 Nov 21.

Institute for Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland

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http://dx.doi.org/10.2967/jnumed.118.216721DOI Listing
July 2019

Preclinical models for the study of Barrett's carcinogenesis.

Ann N Y Acad Sci 2018 12 5;1434(1):139-148. Epub 2018 Jul 5.

Division of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1111/nyas.13916DOI Listing
December 2018

Salvage Surgery for Locoregional Failure in Anal Squamous Cell Carcinoma.

Dis Colon Rectum 2018 Feb;61(2):179-186

Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1097/DCR.0000000000001010DOI Listing
February 2018

Inhibiting system x and glutathione biosynthesis - a potential Achilles' heel in mutant-p53 cancers.

Mol Cell Oncol 2017 5;4(5):e1344757. Epub 2017 Jul 5.

Division of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1080/23723556.2017.1344757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644480PMC
July 2017

Preclinical models of esophageal adenocarcinoma for drug development.

Discov Med 2016 12;22(123):371-379

Division of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria 3000, Australia.

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December 2016

The Genetics of Barrett's Esophagus: A Familial and Population-Based Perspective.

Dig Dis Sci 2016 07 12;61(7):1826-34. Epub 2016 Mar 12.

Division of Cancer Surgery, Peter MacCallum Cancer Centre, A'Beckett Street, Locked bag 1, East Melbourne, VIC, 8006, Australia.

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http://dx.doi.org/10.1007/s10620-016-4109-2DOI Listing
July 2016

Identification of the CIMP-like subtype and aberrant methylation of members of the chromosomal segregation and spindle assembly pathways in esophageal adenocarcinoma.

Carcinogenesis 2016 Apr 10;37(4):356-65. Epub 2016 Feb 10.

Surgical Oncology Group, School of Medicine, The University of Queensland, Translational Research Institute at the Princess Alexandra Hospital, Woolloongabba, Brisbane, Queensland 4102, Australia, Department of Surgery, School of Medicine, The University of Queensland, Princess Alexandra Hospital, Woolloongabba, Brisbane, Queensland 4102, Australia and.

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http://dx.doi.org/10.1093/carcin/bgw018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806711PMC
April 2016

Molecular biology of anal squamous cell carcinoma: implications for future research and clinical intervention.

Lancet Oncol 2015 Dec;16(16):e611-21

Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia; Surgical Oncology Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Victoria, Australia; Department of Surgery, St Vincent's Hospital, University of Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1016/S1470-2045(15)00292-2DOI Listing
December 2015

APR-246 potently inhibits tumour growth and overcomes chemoresistance in preclinical models of oesophageal adenocarcinoma.

Gut 2015 Oct 17;64(10):1506-16. Epub 2015 Jul 17.

Surgical Oncology Research Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia University of Melbourne Department of Surgery, St. Vincent's Hospital, Melbourne, Victoria, Australia.

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http://gut.bmj.com/content/64/10/1506.full.pdf
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http://gut.bmj.com/lookup/doi/10.1136/gutjnl-2015-309770
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http://dx.doi.org/10.1136/gutjnl-2015-309770DOI Listing
October 2015

Heterozygous expression of the oncogenic Pik3ca(H1047R) mutation during murine development results in fatal embryonic and extraembryonic defects.

Dev Biol 2015 Aug 7;404(1):14-26. Epub 2015 May 7.

Cancer Biology and Surgical Oncology Research Laboratory, Peter MacCallum Cancer Centre, St. Andrew's Place, Melbourne, Victoria 3002, Australia; Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton, Victoria 3800, Australia; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria 3010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2015.04.022DOI Listing
August 2015

Intramuscular Transplantation Improves Engraftment Rates for Esophageal Patient-Derived Tumor Xenografts.

Ann Surg Oncol 2016 Jan 18;23(1):305-11. Epub 2015 Feb 18.

Surgical Oncology Research Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1245/s10434-015-4425-3DOI Listing
January 2016

Ubiquitous expression of the Pik3caH1047R mutation promotes hypoglycemia, hypoinsulinemia, and organomegaly.

FASEB J 2015 Apr 30;29(4):1426-34. Epub 2014 Dec 30.

*Surgical Oncology Research Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia; University of Melbourne Department of Medicine, Austin Health, Heidelberg, Victoria, Australia; Translational Research Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia; St. Vincent's Institute of Medical Research and University of Melbourne Department of Medicine, St. Vincent's Hospital, Fitzroy, Victoria, Australia; Bone Research Program, ANZAC Research Institute, The University of Sydney, Sydney, New South Wales, Australia; Differentiation and Transcription Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia; **Department of Pathology, University of Melbourne, Parkville, Victoria, Australia; Molecular Oncology Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia; and University of Melbourne Department of Surgery, St. Vincent's Hospital, Fitzroy, Victoria, Australia

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http://www.fasebj.org/content/29/4/1426.full.pdf
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http://www.fasebj.org/cgi/doi/10.1096/fj.14-262782
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http://dx.doi.org/10.1096/fj.14-262782DOI Listing
April 2015

PI3'-kinase inhibition forestalls the onset of MEK1/2 inhibitor resistance in BRAF-mutated melanoma.

Cancer Discov 2015 Feb 3;5(2):143-53. Epub 2014 Dec 3.

Helen Diller Family Comprehensive Cancer Center and Department of Cell and Molecular Pharmacology, University of California, San Francisco, San Francisco, California.

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http://dx.doi.org/10.1158/2159-8290.CD-14-0856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320669PMC
February 2015

Molecular epidemiology of and genetic susceptibility to esophageal cancer.

Ann N Y Acad Sci 2014 Sep;1325:40-8

Division of GI/Hepatology, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey.

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http://dx.doi.org/10.1111/nyas.12517DOI Listing
September 2014

Esophageal stem cells and genetics/epigenetics in esophageal cancer.

Ann N Y Acad Sci 2014 Sep;1325:8-14

Surgical Oncology Research Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Australia; Department of Surgery (St. Vincent's Hospital), University of Melbourne, Melbourne, Australia.

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http://dx.doi.org/10.1111/nyas.12521DOI Listing
September 2014

Activating BRAF and PIK3CA mutations cooperate to promote anaplastic thyroid carcinogenesis.

Mol Cancer Res 2014 Jul 25;12(7):979-86. Epub 2014 Apr 25.

Authors' Affiliations: Helen Diller Family Comprehensive Cancer Center; Departments of Cell and Molecular Pharmacology, and

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http://dx.doi.org/10.1158/1541-7786.MCR-14-0158-TDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635659PMC
July 2014

Advances in understanding the pathogenesis of Barrett's esophagus.

Discov Med 2014 Jan;17(91):7-14

Surgical Oncology Research Laboratory, Division of Cancer Research, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia and Sir Peter MacCallum Department of Oncology and Department of Surgery (St. Vincent's Hospital), University of Melbourne, Parkville, Victoria 3010, Australia.

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January 2014

Mutationally activated PIK3CA(H1047R) cooperates with BRAF(V600E) to promote lung cancer progression.

Cancer Res 2013 Nov 9;73(21):6448-61. Epub 2013 Sep 9.

Authors' Affiliations: Helen Diller Family Comprehensive Cancer Center; Departments of Cell and Molecular Pharmacology, Hematology and Oncology, and Pathology, University of California, San Francisco, San Francisco, California; and Surgical Oncology Research Laboratory, Sir Peter MacCallum Department of Oncology, Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-0681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825323PMC
November 2013

Synergistic inhibition of ovarian cancer cell growth by combining selective PI3K/mTOR and RAS/ERK pathway inhibitors.

Eur J Cancer 2013 Dec 3;49(18):3936-44. Epub 2013 Sep 3.

Oncogenic Signalling and Growth Control Program, Peter MacCallum Cancer Centre, Locked Bag 1, A'Beckett St, Melbourne, Victoria 8006, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria 3010, Australia; Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria 3010, Australia.

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http://dx.doi.org/10.1016/j.ejca.2013.08.007DOI Listing
December 2013

Molecular changes in the phosphatidylinositide 3-kinase (PI3K) pathway are common in gastric cancer.

J Surg Oncol 2013 Aug 28;108(2):113-20. Epub 2013 Jun 28.

Surgical Oncology Research Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1002/jso.23357DOI Listing
August 2013

Signaling pathways in the molecular pathogenesis of adenocarcinomas of the esophagus and gastroesophageal junction.

Cancer Biol Ther 2013 Sep 17;14(9):782-95. Epub 2013 Jun 17.

St. Vincent's Centre for Applied Medical Research; Sydney, Australia; Notre Dame University School of Medicine; Sydney, Australia.

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http://dx.doi.org/10.4161/cbt.25362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909547PMC
September 2013

Human perforin mutations and susceptibility to multiple primary cancers.

Oncoimmunology 2013 Apr;2(4):e24185

Cancer Immunology Program; Peter MacCallum Cancer Institute; East Melbourne, VIC Australia; and Sir Peter MacCallum Department of Oncology; The University of Melbourne; Melbourne, VIC Australia ; Research Division; Peter MacCallum Cancer Centre; East Melbourne, VIC Australia.

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http://dx.doi.org/10.4161/onci.24185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654607PMC
April 2013

Sox9 drives columnar differentiation of esophageal squamous epithelium: a possible role in the pathogenesis of Barrett's esophagus.

Am J Physiol Gastrointest Liver Physiol 2012 Dec 11;303(12):G1335-46. Epub 2012 Oct 11.

Surgical Oncology Research Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1152/ajpgi.00291.2012DOI Listing
December 2012

Developing a quantitative in vivo tissue reconstitution assay to assess the relative potency of candidate populations of mouse oesophageal epithelial cells.

Methods Mol Biol 2012 ;879:73-88

Surgical Oncology Research Laboratory, MacCllum Cancer Centre, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1007/978-1-61779-815-3_5DOI Listing
September 2012

The developing clinical problem of chemotherapy-induced hepatic injury.

ANZ J Surg 2012 Jan-Feb;82(1-2):23-9. Epub 2011 May 17.

Division of Cancer Surgery, Peter MacCallum Cancer, Melbourne, Australia.

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http://dx.doi.org/10.1111/j.1445-2197.2011.05789.xDOI Listing
August 2012

Targeting PI3 kinase/AKT/mTOR signaling in cancer.

Crit Rev Oncog 2012 ;17(1):69-95

Division of Cancer Research, Peter MacCallum Cancer Centre, Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia.

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http://dx.doi.org/10.1615/critrevoncog.v17.i1.60DOI Listing
May 2012

mRNA gene expression correlates with histologically diagnosed chemotherapy-induced hepatic injury.

HPB (Oxford) 2011 Nov 2;13(11):811-6. Epub 2011 Aug 2.

Division of Cancer Surgery, The Alfred Hospital Department of Pathology, The Alfred Hospital, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1111/j.1477-2574.2011.00365.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3238016PMC
November 2011

Pretreatment transcriptional profiling for predicting response to neoadjuvant chemoradiotherapy in rectal adenocarcinoma.

Clin Cancer Res 2011 May 11;17(9):3039-47. Epub 2011 Jan 11.

Division of Cancer Research, Department of Pathology, and Centre for Molecular Imaging, Radiation Oncology Victoria, East Melbourne, Australia.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-2915DOI Listing
May 2011

Barrett's esophagus.

J Gastroenterol Hepatol 2011 Apr;26(4):639-48

Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1111/j.1440-1746.2010.06602.xDOI Listing
April 2011

Selective inhibition of proliferation in colorectal carcinoma cell lines expressing mutant APC or activated B-Raf.

Int J Cancer 2009 Jul;125(2):297-307

Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Centre for Medical Research, Victoria, Australia.

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http://dx.doi.org/10.1002/ijc.24289DOI Listing
July 2009

Esophageal stem cells--a review of their identification and characterization.

Stem Cell Rev 2008 Dec 5;4(4):261-8. Epub 2008 Aug 5.

Surgical Oncology Research Laboratory, Peter MacCallum Cancer Centre, Locked Bag 1, A'Beckett Street, Melbourne, Victoria 8006, Australia.

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http://dx.doi.org/10.1007/s12015-008-9031-3DOI Listing
December 2008

Reconstitution of stratified murine and human oesophageal epithelia in an in vivo transplant culture system.

Scand J Gastroenterol 2008 ;43(10):1158-68

Peter MacCallum Cancer Centre, Surgical Oncology Research Laboratory, Melbourne, Victoria, Australia.

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http://www.tandfonline.com/doi/full/10.1080/0036552080210248
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http://dx.doi.org/10.1080/00365520802102489DOI Listing
February 2009

Pretreatment gene expression profiles can be used to predict response to neoadjuvant chemoradiotherapy in esophageal cancer.

Ann Surg Oncol 2007 Dec 26;14(12):3602-9. Epub 2007 Sep 26.

Division of Surgical Oncology, Peter MacCallum Cancer Centre, St. Andrew's Place, East Melbourne, Victoria, 3002, Australia.

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http://dx.doi.org/10.1245/s10434-007-9550-1DOI Listing
December 2007

Gene expression profiling of esophageal cancer: comparative analysis of Barrett's esophagus, adenocarcinoma, and squamous cell carcinoma.

Int J Cancer 2007 May;120(9):1914-21

Division of Surgical Oncology, Peter MacCallum Cancer Centre, St. Andrew's Place, East Melbourne, Vic, Australia.

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http://dx.doi.org/10.1002/ijc.22501DOI Listing
May 2007

A specific role for AKT3 in the genesis of ovarian cancer through modulation of G(2)-M phase transition.

Cancer Res 2006 Dec;66(24):11718-25

Growth Control and Differentiation Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-1968DOI Listing
December 2006

Identification of candidate murine esophageal stem cells using a combination of cell kinetic studies and cell surface markers.

Stem Cells 2007 Feb 12;25(2):313-8. Epub 2006 Oct 12.

Surgical Oncology Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1634/stemcells.2006-0421DOI Listing
February 2007

Genetic and epigenetic analysis of the putative tumor suppressor km23 in primary ovarian, breast, and colorectal cancers.

Clin Cancer Res 2006 Jun;12(12):3713-5

Victorian Breast Cancer Research Consortium Cancer Genetics Laboratory, Research Division, Peter MacCallum Cancer Centre, Melbourne, 8006, Australia.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-06-0800DOI Listing
June 2006

Mutation analysis of PIK3CA and PIK3CB in esophageal cancer and Barrett's esophagus.

Int J Cancer 2006 May;118(10):2644-6

Surgical Oncology Laboratory, Peter MacCallum Cancer Centre, and Department of Surgery (St. Vincent's Hospital), University of Melbourne, Parkville, VIC, Australia.

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http://dx.doi.org/10.1002/ijc.21706DOI Listing
May 2006

PIK3CA mutations in ovarian cancer.

Clin Cancer Res 2005 Oct;11(19 Pt 1):7042; author reply 7042-3

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http://dx.doi.org/10.1158/1078-0432.CCR-05-1024DOI Listing
October 2005

Mutation of the PIK3CA gene in ovarian and breast cancer.

Cancer Res 2004 Nov;64(21):7678-81

VBCRC Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-2933DOI Listing
November 2004

Regulation of phosphoinositide 3-kinase by its intrinsic serine kinase activity in vivo.

Mol Cell Biol 2004 Feb;24(3):966-75

Department of Biochemistry and Molecular Biology, University College London, London WC1E 6BT, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC321424PMC
http://dx.doi.org/10.1128/mcb.24.3.966-975.2004DOI Listing
February 2004