Wataru Kakegawa

Wataru Kakegawa

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Wataru Kakegawa

Wataru Kakegawa

Publications by authors named "Wataru Kakegawa"

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Interneuronal NMDA receptors regulate long-term depression and motor learning in the cerebellum.

J Physiol 2019 Feb 24;597(3):903-920. Epub 2018 Nov 24.

Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.

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http://doi.wiley.com/10.1113/JP276794
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http://dx.doi.org/10.1113/JP276794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355717PMC
February 2019

Optogenetic Control of Synaptic AMPA Receptor Endocytosis Reveals Roles of LTD in Motor Learning.

Neuron 2018 Sep 16;99(5):985-998.e6. Epub 2018 Aug 16.

Department of Physiology, Keio University School of Medicine, Tokyo 160-8582, Japan; Department of Engineering Science, Graduate School of Informatics and Engineering, The University of Electro-Communications, Tokyo 182-8585, Japan; Japan Science and Technology Agency, PRESTO, 4-1-8 Honcho Kawaguchi, Saitama 332-0012, Japan; Brain Science Inspired Life Support Research Center (BLSC), The University of Electro-Communications, Tokyo 182-8585, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.07.034DOI Listing
September 2018

[Molecular Mechanisms for Learning and Memory: What Happens at the Synapses?]

Brain Nerve 2018 Jul;70(7):677-687

Department of Physiology, Keio University School of Medicine.

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http://dx.doi.org/10.11477/mf.1416201069DOI Listing
July 2018

Chemical labelling for visualizing native AMPA receptors in live neurons.

Nat Commun 2017 04 7;8:14850. Epub 2017 Apr 7.

Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku 615-8510, Japan.

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http://dx.doi.org/10.1038/ncomms14850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385570PMC
April 2017

Transsynaptic Modulation of Kainate Receptor Functions by C1q-like Proteins.

Neuron 2016 05 28;90(4):752-67. Epub 2016 Apr 28.

Department of Physiology, Keio University School of Medicine, Tokyo 160-8582, Japan; Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Tokyo 102-0075, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2016.04.001DOI Listing
May 2016

RORα Regulates Multiple Aspects of Dendrite Development in Cerebellar Purkinje Cells In Vivo.

J Neurosci 2015 Sep;35(36):12518-34

Department of Physiology, Keio University School of Medicine, Tokyo 160-8582, Japan, and Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Tokyo 102-0075, Japan

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http://dx.doi.org/10.1523/JNEUROSCI.0075-15.2015DOI Listing
September 2015

Anterograde C1ql1 signaling is required in order to determine and maintain a single-winner climbing fiber in the mouse cerebellum.

Neuron 2015 Jan;85(2):316-29

Department of Physiology, Keio University School of Medicine, Tokyo 160-8582, Japan; Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Tokyo 102-0075, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2014.12.020DOI Listing
January 2015

Stargazin regulates AMPA receptor trafficking through adaptor protein complexes during long-term depression.

Nat Commun 2013 ;4:2759

1] Department of Physiology, School of Medicine, Keio University, Tokyo 160-8582, Japan [2] Japan Science and Technology Agency, PRESTO, 4-1-8 Honcho Kawaguchi, Saitama 332-0012, Japan.

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http://dx.doi.org/10.1038/ncomms3759DOI Listing
June 2014

Reevaluation of the role of parallel fiber synapses in delay eyeblink conditioning in mice using Cbln1 as a tool.

Front Neural Circuits 2013 15;7:180. Epub 2013 Nov 15.

Department of Physiology, School of Medicine, Keio University Shinjuku-ku, Tokyo, Japan ; Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation Kawaguchi, Saitama, Japan.

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http://dx.doi.org/10.3389/fncir.2013.00180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828671PMC
April 2014

Cbln1 downregulates the formation and function of inhibitory synapses in mouse cerebellar Purkinje cells.

Eur J Neurosci 2014 Apr 27;39(8):1268-80. Epub 2014 Jan 27.

Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Corporation, Kawaguchi, Saitama, Japan; Department of Cellular Neurobiology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan; Department of Physiology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.

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http://dx.doi.org/10.1111/ejn.12487DOI Listing
April 2014

Unlocking the secrets of the δ2 glutamate receptor: A gatekeeper for synaptic plasticity in the cerebellum.

Commun Integr Biol 2013 Nov 27;6(6):e26466. Epub 2013 Sep 27.

Department of Physiology; Keio University School of Medicine; Tokyo, Japan.

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http://dx.doi.org/10.4161/cib.26466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916355PMC
November 2013

Deletions in GRID2 lead to a recessive syndrome of cerebellar ataxia and tonic upgaze in humans.

Neurology 2013 Oct 27;81(16):1378-86. Epub 2013 Sep 27.

From the Division of Genetics (L.B.H., A.-T.N.L., R.S.H., J.N.P., M.A.-S., J.M.S., G.H.M.) and Division of Developmental Medicine (R.N.), Department of Medicine, and Howard Hughes Medical Institute (J.N.P.), Boston Children's Hospital, Boston, MA; Division of Child Neurology (A.M.), Department of Pediatrics, Jordan University Hospital, Amman, Jordan; Department of Anatomy (K.K., M.W.), Hokkaido University Graduate School of Medicine, Sapporo, Japan; Department of Physiology (W.K., M.Y.), School of Medicine, Keio University, Tokyo, Japan; Department of Pediatrics (E.L.-M., N.C.), New York Medical College, Valhalla, NY; Department of Pediatrics (M.A.-S.), Faculty of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates; Department of Pediatrics (R.N., J.M.S., G.H.M.), Harvard Medical School, Boston, MA; Department of Radiology and Biomedical Imaging (A.J.B.), University of California, San Francisco; and Pediatric Neurology Unit (G.H.M.), Department of Neurology, Massachusetts General Hospital, Boston.

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http://dx.doi.org/10.1212/WNL.0b013e3182a841a3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806907PMC
October 2013

CAPS1 deficiency perturbs dense-core vesicle trafficking and Golgi structure and reduces presynaptic release probability in the mouse brain.

J Neurosci 2013 Oct;33(44):17326-34

Advanced Scientific Research Leaders Development Unit and Department of Molecular and Cellular Neurobiology, Graduate School of Medicine, Gunma University, Maebashi, Gunma 371-8511, Japan, Japan Science and Technology Agency/Core Research for Evolutional Science and Technology, Kawaguchi, Saitama 332-0012, Japan, Department of Physiology, School of Medicine, Keio University, Tokyo 160-8582, Japan, Department of Applied Biological Science, Tokyo University of Science, Noda, Chiba 278-8510, Japan, Graduate School of Medical Science, Department of Molecular Virology and Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa 920-1192, Japan, Department of Biochemistry, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka 537-8511, Japan, Laboratory for Behavioral Genetics, Funding Program for World-Leading Innovative R&D on Science and Technology, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan, Department of Developmental Genetics, National Institute of Genetics, Mishima, Shizuoka 411-8540, Japan, and Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan.

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http://dx.doi.org/10.1523/JNEUROSCI.2777-13.2013DOI Listing
October 2013

The δ2 glutamate receptor gates long-term depression by coordinating interactions between two AMPA receptor phosphorylation sites.

Proc Natl Acad Sci U S A 2013 Mar 19;110(10):E948-57. Epub 2013 Feb 19.

Department of Physiology, School of Medicine, Keio University, Shinjuku-ku, Tokyo 160-8582, Japan.

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http://dx.doi.org/10.1073/pnas.1218380110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3593918PMC
March 2013

Selective and regulated gene expression in murine Purkinje cells by in utero electroporation.

Eur J Neurosci 2012 Oct 10;36(7):2867-76. Epub 2012 Jul 10.

Department of Physiology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

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http://dx.doi.org/10.1111/j.1460-9568.2012.08203.xDOI Listing
October 2012

Cerebellar long-term depression requires dephosphorylation of TARP in Purkinje cells.

Eur J Neurosci 2012 Feb 12;35(3):402-10. Epub 2012 Jan 12.

Department of Physiology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

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http://dx.doi.org/10.1111/j.1460-9568.2011.07963.xDOI Listing
February 2012

NMDA receptor-mediated PIP5K activation to produce PI(4,5)P₂ is essential for AMPA receptor endocytosis during LTD.

Neuron 2012 Jan;73(1):135-48

Department of Physiological Chemistry, Graduate School of Comprehensive Human Sciences and Institute of Basic Medical Sciences, University of Tsukuba, 1-1-1 Ten-nohdai, Tsukuba 305-8571, Japan.

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http://dx.doi.org/10.1016/j.neuron.2011.09.034DOI Listing
January 2012

A new rapid protocol for eyeblink conditioning to assess cerebellar motor learning.

Neurochem Res 2011 Jul 9;36(7):1314-22. Epub 2011 Jan 9.

Department of Physiology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.

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http://dx.doi.org/10.1007/s11064-010-0392-zDOI Listing
July 2011

D-serine regulates cerebellar LTD and motor coordination through the δ2 glutamate receptor.

Nat Neurosci 2011 May 3;14(5):603-11. Epub 2011 Apr 3.

Department of Physiology, School of Medicine, Keio University, Shinjuku-ku, Tokyo, Japan.

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http://www.nature.com/articles/nn.2791
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http://dx.doi.org/10.1038/nn.2791DOI Listing
May 2011

Reevaluation of neurodegeneration in lurcher mice: constitutive ion fluxes cause cell death with, not by, autophagy.

J Neurosci 2010 Feb;30(6):2177-87

Department of Physiology, School of Medicine, Keio University, Tokyo 160-8582, Japan.

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http://dx.doi.org/10.1523/JNEUROSCI.6030-09.2010DOI Listing
February 2010

Phosphorylation of delta2 glutamate receptors at serine 945 is not required for cerebellar long-term depression.

Keio J Med 2008 Jun;57(2):105-10

Department of Physiology, School of Medicine, Keio University, Department of Psychiatry, University of Tokyo, Tokyo, Japan.

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June 2008

Accumulation of AMPA receptors in autophagosomes in neuronal axons lacking adaptor protein AP-4.

Neuron 2008 Mar;57(5):730-45

Department of Physiology, School of Medicine, Keio University, Tokyo 160-8582, Japan.

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http://dx.doi.org/10.1016/j.neuron.2008.02.012DOI Listing
March 2008

The delta2 'ionotropic' glutamate receptor functions as a non-ionotropic receptor to control cerebellar synaptic plasticity.

J Physiol 2007 Oct 16;584(Pt 1):89-96. Epub 2007 Aug 16.

Department of Physiology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

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http://dx.doi.org/10.1113/jphysiol.2007.141291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2277055PMC
October 2007

Ho15J: a new hotfoot allele in a hot spot in the gene encoding the delta2 glutamate receptor.

Brain Res 2007 Apr 2;1140:153-60. Epub 2006 May 2.

Department of Physiology, Keio University School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.brainres.2006.03.068DOI Listing
April 2007

The extreme C-terminus of GluRdelta2 is essential for induction of long-term depression in cerebellar slices.

Eur J Neurosci 2007 Mar;25(5):1357-62

Department of Physiology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

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http://dx.doi.org/10.1111/j.1460-9568.2007.05412.xDOI Listing
March 2007

ERK1/2 but not p38 MAP kinase is essential for the long-term depression in mouse cerebellar slices.

Eur J Neurosci 2006 Sep;24(6):1617-22

Department of Physiology, School of Medicine, Keio University, 35 Shinano-machi, Shinjuku-ku, Tokyo 160-8582, Tokyo 160-8582, Japan.

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http://dx.doi.org/10.1111/j.1460-9568.2006.05055.xDOI Listing
September 2006

A mechanism underlying AMPA receptor trafficking during cerebellar long-term potentiation.

Proc Natl Acad Sci U S A 2005 Dec 22;102(49):17846-51. Epub 2005 Nov 22.

Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

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http://dx.doi.org/10.1073/pnas.0508910102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1308917PMC
December 2005

Induction of long-term depression and phosphorylation of the delta2 glutamate receptor by protein kinase C in cerebellar slices.

Eur J Neurosci 2005 Oct;22(7):1817-20

Molecular Neurophysiology, Neuroscience Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba 305-8566, Japan.

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http://dx.doi.org/10.1111/j.1460-9568.2005.04319.xDOI Listing
October 2005

Differential roles of glial and neuronal glutamate transporters in Purkinje cell synapses.

J Neurosci 2005 Sep;25(38):8788-93

Department of Neurophysiology, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511, Japan.

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http://dx.doi.org/10.1523/JNEUROSCI.1020-05.2005DOI Listing
September 2005

Rescue of abnormal phenotypes of the delta2 glutamate receptor-null mice by mutant delta2 transgenes.

EMBO Rep 2005 Jan;6(1):90-5

Deptartment of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1038/sj.embor.7400312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1299222PMC
January 2005

Input- and subunit-specific AMPA receptor trafficking underlying long-term potentiation at hippocampal CA3 synapses.

Eur J Neurosci 2004 Jul;20(1):101-10

Department of Neurophysiology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan.

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http://dx.doi.org/10.1111/j.1460-9568.2004.03461.xDOI Listing
July 2004

Functional NMDA receptor channels generated by NMDAR2B gene transfer in rat cerebellar Purkinje cells.

Eur J Neurosci 2003 Feb;17(4):887-91

Department of Physiology, Gunma University School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan.

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February 2003

Postsynaptic expression of a new calcium pathway in hippocampal CA3 neurons and its influence on mossy fiber long-term potentiation.

J Neurosci 2002 Jun;22(11):4312-20

Department of Physiology, Gunma University School of Medicine, Maebashi, Gunma 371-8511, Japan.

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http://dx.doi.org/20026460DOI Listing
June 2002