Warren S Pear

Warren S Pear

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Warren S Pear

Publications by authors named "Warren S Pear"

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Trib1 regulates T cell differentiation during chronic infection by restraining the effector program.

J Exp Med 2020 May;217(5)

Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1084/jem.20190888DOI Listing
May 2020

TooManyCells identifies and visualizes relationships of single-cell clades.

Nat Methods 2020 Apr 2;17(4):405-413. Epub 2020 Mar 2.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1038/s41592-020-0748-5DOI Listing
April 2020

Transcription factor and cytokine regulation of eosinophil lineage commitment.

Curr Opin Hematol 2020 Jan;27(1):27-33

Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1097/MOH.0000000000000552DOI Listing
January 2020

Oncogenic Notch Promotes Long-Range Regulatory Interactions within Hyperconnected 3D Cliques.

Mol Cell 2019 03 7;73(6):1174-1190.e12. Epub 2019 Feb 7.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765193000
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http://dx.doi.org/10.1016/j.molcel.2019.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485942PMC
March 2019

Can genetics resolve what Notch does in HSCs?

Blood 2018 04;131(15):1633-1635

University of Pennsylvania.

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http://dx.doi.org/10.1182/blood-2018-02-829069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897870PMC
April 2018

Lineage-Determining Transcription Factor TCF-1 Initiates the Epigenetic Identity of T Cells.

Immunity 2018 02;48(2):243-257.e10

Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10747613183003
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http://dx.doi.org/10.1016/j.immuni.2018.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824646PMC
February 2018

The common oncogenomic program of NOTCH1 and NOTCH3 signaling in T-cell acute lymphoblastic leukemia.

PLoS One 2017 12;12(10):e0185762. Epub 2017 Oct 12.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0185762PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638296PMC
October 2017

Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand.

PLoS One 2016 13;11(9):e0161157. Epub 2016 Sep 13.

Department of Neurology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0161157PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021350PMC
August 2017

Trib2 Suppresses Tumor Initiation in Notch-Driven T-ALL.

PLoS One 2016 18;11(5):e0155408. Epub 2016 May 18.

Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Institute of Medicine and Engineering, Institute for Immunology, Center for Personalized Diagnostics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0155408PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871414PMC
July 2017

The Varied Roles of Notch in Cancer.

Annu Rev Pathol 2017 Jan 5;12:245-275. Epub 2016 Dec 5.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115.

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http://dx.doi.org/10.1146/annurev-pathol-052016-100127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933931PMC
January 2017

High selective pressure for Notch1 mutations that induce Myc in T-cell acute lymphoblastic leukemia.

Blood 2016 11 26;128(18):2229-2240. Epub 2016 Sep 26.

Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Institute of Medicine and Engineering, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; and.

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http://dx.doi.org/10.1182/blood-2016-01-692855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095757PMC
November 2016

Structural Basis for Substrate Selectivity of the E3 Ligase COP1.

Structure 2016 05 31;24(5):687-696. Epub 2016 Mar 31.

Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.str.2016.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856590PMC
May 2016

Tribbles at the cross-roads….

Biochem Soc Trans 2015 Oct;43(5):1049-50

Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, PA 19104, U.S.A.

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http://dx.doi.org/10.1042/BST20150122DOI Listing
October 2015

Tribbles in normal and malignant haematopoiesis.

Biochem Soc Trans 2015 Oct;43(5):1112-5

Department of Pathology and Laboratory Medicine, Institute for Immunology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, U.S.A.

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http://dx.doi.org/10.1042/BST20150117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613494PMC
October 2015

Identifying direct Notch transcriptional targets using the GSI-washout assay.

Methods Mol Biol 2014 ;1187:247-54

Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, and Institute for Immunology, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1007/978-1-4939-1139-4_19DOI Listing
March 2015

Loss of oncogenic Notch1 with resistance to a PI3K inhibitor in T-cell leukaemia.

Nature 2014 Sep 20;513(7519):512-6. Epub 2014 Jul 20.

Department of Pediatrics and Benniof Children's Hospital, University of California, San Francisco, California 94143, USA.

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http://dx.doi.org/10.1038/nature13495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213126PMC
September 2014

NOTCH1-RBPJ complexes drive target gene expression through dynamic interactions with superenhancers.

Proc Natl Acad Sci U S A 2014 Jan 27;111(2):705-10. Epub 2013 Dec 27.

Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115.

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http://dx.doi.org/10.1073/pnas.1315023111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896193PMC
January 2014

T cell development requires constraint of the myeloid regulator C/EBP-α by the Notch target and transcriptional repressor Hes1.

Nat Immunol 2013 Dec 3;14(12):1277-84. Epub 2013 Nov 3.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1038/ni.2760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038953PMC
December 2013

Notch simultaneously orchestrates multiple helper T cell programs independently of cytokine signals.

Immunity 2013 Jul;39(1):148-59

Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.immuni.2013.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762693PMC
July 2013

The expression of Sox17 identifies and regulates haemogenic endothelium.

Nat Cell Biol 2013 May 21;15(5):502-10. Epub 2013 Apr 21.

McEwen Centre for Regenerative Medicine, University Health Network, Toronto, Ontario M5G 1L7, Canada.

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http://dx.doi.org/10.1038/ncb2724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011511PMC
May 2013

Brief report: Blockade of Notch signaling in muscle stem cells causes muscular dystrophic phenotype and impaired muscle regeneration.

Stem Cells 2013 Apr;31(4):823-8

Department of Molecular Genetics and Microbiology, Shands Cancer Center, University of Florida, Gainesville, Florida 32610-3633, USA.

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http://dx.doi.org/10.1002/stem.1319DOI Listing
April 2013

Divergent effects of supraphysiologic Notch signals on leukemia stem cells and hematopoietic stem cells.

Blood 2013 Feb 31;121(6):905-17. Epub 2012 Oct 31.

Division of Hematology-Oncology and the University of Michigan Cancer Center, University of Michigan, Ann Arbor, MI, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2012-03-41
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http://dx.doi.org/10.1182/blood-2012-03-416503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567338PMC
February 2013

Mastermind-like transcriptional co-activator-mediated Notch signaling is indispensable for maintaining conjunctival epithelial identity.

Development 2013 Feb;140(3):594-605

Edith J. Crawley Vision Research Center/Department of Ophthalmology, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.

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http://dx.doi.org/10.1242/dev.082842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561782PMC
February 2013

Notch and PI3K: how is the road traveled?

Blood 2012 Aug;120(7):1349-50

University of Pennsylvania Perelman School of Medicine.

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http://dx.doi.org/10.1182/blood-2012-06-435099DOI Listing
August 2012

Critical roles of NOTCH1 in acute T-cell lymphoblastic leukemia.

Int J Hematol 2011 Aug 5;94(2):118-125. Epub 2011 Aug 5.

Department of Pathology and Laboratory Medicine and Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA, 19104, USA.

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http://www.springerlink.com/index/k104563m626u5tv8.pdf
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http://link.springer.com/content/pdf/10.1007/s12185-011-0899
Web Search
http://link.springer.com/10.1007/s12185-011-0899-3
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http://dx.doi.org/10.1007/s12185-011-0899-3DOI Listing
August 2011

RBP-J promotes the maturation of neuronal progenitors.

Dev Biol 2011 Jun 2;354(1):44-54. Epub 2011 Apr 2.

Laboratory of Molecular Neuroscience, School of Biomedical Science and Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.ydbio.2011.03.020DOI Listing
June 2011

Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies.

J Pathol 2011 Jan 21;223(2):262-73. Epub 2010 Oct 21.

Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://doi.wiley.com/10.1002/path.2789
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http://dx.doi.org/10.1002/path.2789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996483PMC
January 2011

Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding.

Blood 2010 Dec 30;116(23):4948-57. Epub 2010 Aug 30.

Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1182/blood-2009-10-247361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012589PMC
December 2010

Notch dimerization is required for leukemogenesis and T-cell development.

Genes Dev 2010 Nov 8;24(21):2395-407. Epub 2010 Oct 8.

Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1101/gad.1975210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964750PMC
November 2010

Hooked on Hes: a T-ALL of addiction.

Authors:
Warren S Pear

Immunity 2010 Nov;33(5):645-7

Department of Pathology and Laboratory Medicine and Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.immuni.2010.11.018DOI Listing
November 2010

Notch regulation of early thymocyte development.

Semin Immunol 2010 Oct 13;22(5):261-9. Epub 2010 Jul 13.

The Department of Pathology & Laboratory Medicine and the Abramson Family Cancer Research Institute at the University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1016/j.smim.2010.04.015DOI Listing
October 2010

Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia.

Blood 2010 Aug 21;116(8):1321-8. Epub 2010 Apr 21.

Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Institute for Medicine & Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1182/blood-2009-07-229450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938240PMC
August 2010

HIV-1 Rev-binding protein accelerates cellular uptake of iron to drive Notch-induced T cell leukemogenesis in mice.

J Clin Invest 2010 Jul;120(7):2537-48

Department of Biochemistry and Molecular Biology, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1172/JCI41277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898592PMC
July 2010

New roles for Notch in tuberous sclerosis.

Authors:
Warren S Pear

J Clin Invest 2010 Jan 28;120(1):84-7. Epub 2009 Dec 28.

Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104-6160, USA.

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http://dx.doi.org/10.1172/JCI41897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798710PMC
January 2010

Murine Jagged1/Notch signaling in the second heart field orchestrates Fgf8 expression and tissue-tissue interactions during outflow tract development.

J Clin Invest 2009 Jul 8;119(7):1986-96. Epub 2009 Jun 8.

Department of Cell and Developmental Biology, Cardiovascular Institute, and Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1172/JCI38922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701882PMC
July 2009

Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A.

Genes Dev 2009 Jul;23(14):1665-76

Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://genesdev.cshlp.org/content/23/14/1665.full.pdf
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http://genesdev.cshlp.org/cgi/doi/10.1101/gad.1793709
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http://dx.doi.org/10.1101/gad.1793709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714710PMC
July 2009

Menin regulates the function of hematopoietic stem cells and lymphoid progenitors.

Blood 2009 Feb;113(8):1661-9

Center for Stem Cell Biology, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1182/blood-2009-01-135012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647667PMC
February 2009

Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia.

J Clin Invest 2008 Sep;118(9):3181-94

Division of Hematology-Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1172/JCI35090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2491459PMC
September 2008

Notch signaling specifies megakaryocyte development from hematopoietic stem cells.

Cell Stem Cell 2008 Sep;3(3):314-26

Department of Medicine, Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 20115, USA.

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http://dx.doi.org/10.1016/j.stem.2008.07.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970322PMC
September 2008

Notch2 paves the way to mast cells by Hes1 and Gata3.

Proc Natl Acad Sci U S A 2008 Jun 30;105(22):7629-30. Epub 2008 May 30.

Abramson Family Cancer Research Institute, Department of Pathology and Laboratory Medicine, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1073/pnas.0803439105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409425PMC
June 2008

Notch signaling in leukemia.

Annu Rev Pathol 2008 ;3:587-613

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1146/annurev.pathmechdis.3.121806.154300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934586PMC
May 2008

Tribbles homolog 2 (Trib2) and HoxA9 cooperate to accelerate acute myelogenous leukemia.

Blood Cells Mol Dis 2008 Jan-Feb;40(1):119-21. Epub 2007 Nov 7.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104-6160, USA.

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http://dx.doi.org/10.1016/j.bcmd.2007.06.005DOI Listing
February 2008

Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development.

Proc Natl Acad Sci U S A 2008 Feb 1;105(6):1955-9. Epub 2008 Feb 1.

Department of Cell and Developmental Biology and Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1073/pnas.0709663105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2538864PMC
February 2008

The transcriptional coactivator Maml1 is required for Notch2-mediated marginal zone B-cell development.

Blood 2007 Nov 15;110(10):3618-23. Epub 2007 Aug 15.

Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2007-06-09
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http://dx.doi.org/10.1182/blood-2007-06-097030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2077311PMC
November 2007

Notch1 co-opts lymphoid enhancer factor 1 for survival of murine T-cell lymphomas.

Blood 2007 Oct 21;110(7):2650-8. Epub 2007 Jun 21.

Department of Pathology, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1182/blood-2007-04-084202DOI Listing
October 2007

Notch signaling in vascular smooth muscle cells is required to pattern the cerebral vasculature.

Proc Natl Acad Sci U S A 2007 Oct 1;104(41):16275-80. Epub 2007 Oct 1.

Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1073/pnas.0707950104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2042197PMC
October 2007

Notch directly regulates Gata3 expression during T helper 2 cell differentiation.

Immunity 2007 Jul 19;27(1):100-10. Epub 2007 Jul 19.

Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S10747613070033
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http://dx.doi.org/10.1016/j.immuni.2007.04.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801546PMC
July 2007

Immunology. Keeping a tight leash on Notch.

Science 2007 May;316(5826):840-2

Division of Hematology-Oncology, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1126/science.1143336DOI Listing
May 2007

Notch activity synergizes with B-cell-receptor and CD40 signaling to enhance B-cell activation.

Blood 2007 Apr 19;109(8):3342-50. Epub 2006 Dec 19.

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 36th and Hamilton Walk, Philadelphia, PA 19104, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2006-09-04
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http://dx.doi.org/10.1182/blood-2006-09-046698DOI Listing
April 2007

The multifaceted role of Notch in cancer.

Curr Opin Genet Dev 2007 Feb 18;17(1):52-9. Epub 2006 Dec 18.

Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0959437X0600236
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http://dx.doi.org/10.1016/j.gde.2006.12.001DOI Listing
February 2007

Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription.

Proc Natl Acad Sci U S A 2007 Feb 6;104(7):2103-8. Epub 2007 Feb 6.

Department of Pathology, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.0611092104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892977PMC
February 2007

Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia.

Cancer Cell 2006 Nov;10(5):401-11

Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1016/j.ccr.2006.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839500PMC
November 2006

Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1.

Mol Cell Biol 2006 Aug;26(16):6261-71

Department of Hematology/Oncology, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.02478-05
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http://dx.doi.org/10.1128/MCB.02478-05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1592797PMC
August 2006

Impaired notch signaling promotes de novo squamous cell carcinoma formation.

Cancer Res 2006 Aug;66(15):7438-44

Cardiovascular Institute, and Department of Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-06-0793DOI Listing
August 2006

The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression.

Proc Natl Acad Sci U S A 2006 Jan 13;103(4):1018-23. Epub 2006 Jan 13.

Abramson Family Cancer Research Institute, Department of Cancer Biology, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104-6160, USA.

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http://dx.doi.org/10.1073/pnas.0510347103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1326489PMC
January 2006

Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies.

Blood 2005 Dec 23;106(12):3898-906. Epub 2005 Aug 23.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, 611 BRB II/III, 421 Curie Blvd, Philadelphia, PA 19104-6160, USA.

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http://dx.doi.org/10.1182/blood-2005-01-0355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895093PMC
December 2005

Lasting longer without oxygen: The influence of hypoxia on Notch signaling.

Cancer Cell 2005 Dec;8(6):435-7

Abramson Family Cancer Research Institute, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1016/j.ccr.2005.11.016DOI Listing
December 2005

Notch signaling is an important regulator of type 2 immunity.

J Exp Med 2005 Oct;202(8):1037-42

Department of Pathology and Laboratory Medicine, School of Veterinary Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1084/jem.20050923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213210PMC
October 2005

Notch signaling controls the generation and differentiation of early T lineage progenitors.

Nat Immunol 2005 Jul 12;6(7):663-70. Epub 2005 Jun 12.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1038/ni1216DOI Listing
July 2005

Regulation of lymphoid development, differentiation, and function by the Notch pathway.

Annu Rev Immunol 2005 ;23:945-74

Division of Hematology-Oncology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6160, USA.

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http://dx.doi.org/10.1146/annurev.immunol.23.021704.115747DOI Listing
June 2005

Cancer genetics: activated notch takes center stage in T-cell leukemogenesis.

Eur J Hum Genet 2005 Apr;13(4):393-5

Division of Hematology and Oncology, Department of Medicine, University of Pennsylvania Medical Center, 611 BRB 2/3, 421 Curie Blvd, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1038/sj.ejhg.5201380DOI Listing
April 2005

Notch signaling represses myocardin-induced smooth muscle cell differentiation.

J Biol Chem 2005 Mar 4;280(10):8994-9004. Epub 2005 Jan 4.

Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://www.jbc.org/cgi/doi/10.1074/jbc.M413316200
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http://dx.doi.org/10.1074/jbc.M413316200DOI Listing
March 2005

T cell acute lymphoblastic leukemia/lymphoma: a human cancer commonly associated with aberrant NOTCH1 signaling.

Curr Opin Hematol 2004 Nov;11(6):426-33

Abramson Center Cancer Research Institute, Institute for Medicine & Engineering and Department of Pathology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1097/01.moh.0000143965.90813.70DOI Listing
November 2004

Notch and T cell malignancy.

Semin Cancer Biol 2004 Oct;14(5):329-40

Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.semcancer.2004.04.012DOI Listing
October 2004

Mastermind critically regulates Notch-mediated lymphoid cell fate decisions.

Blood 2004 Sep 8;104(6):1696-702. Epub 2004 Jun 8.

Division of Hematology-Oncology, Abramson Family Cancer Research Institute, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104-6160, USA.

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http://dx.doi.org/10.1182/blood-2004-02-0514DOI Listing
September 2004

Notch 1 signaling regulates peripheral T cell activation.

Immunity 2004 Apr;20(4):407-15

Diabetes Center and Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 USA.

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http://dx.doi.org/10.1016/s1074-7613(04)00081-0DOI Listing
April 2004

NF-kB inhibitor blocks B cell development at two checkpoints.

Med Immunol 2004 Mar 29;3(1). Epub 2004 Mar 29.

Division of Immunology, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA.

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http://dx.doi.org/10.1186/1476-9433-3-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC419369PMC
March 2004