Publications by authors named "Warren S Alexander"

100Publications

Downregulation of the GHRH/GH/IGF-1 axis in a mouse model of Börjeson-Forssman-Lehman Syndrome.

Development 2020 Sep 29. Epub 2020 Sep 29.

Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3052, Australia

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http://dx.doi.org/10.1242/dev.187021DOI Listing
September 2020

A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction.

Nat Commun 2020 06 19;11(1):3150. Epub 2020 Jun 19.

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.

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http://dx.doi.org/10.1038/s41467-020-16819-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305203PMC
June 2020

Targeting platelets for improved outcome in KRAS-driven lung adenocarcinoma.

Oncogene 2020 Jul 13;39(29):5177-5186. Epub 2020 Jun 13.

ACRF Cancer Biology & Stem Cells Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1038/s41388-020-1357-6DOI Listing
July 2020

Perturbation of the immune cells and prenatal neurogenesis by the triplication of the Erg gene in mouse models of Down syndrome.

Brain Pathol 2020 01 4;30(1):75-91. Epub 2019 Jul 4.

Department of Pathological Biochemistry, Division of Pathological Sciences, Kyoto Pharmaceutical University, Kyoto, Japan.

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http://dx.doi.org/10.1111/bpa.12758DOI Listing
January 2020

Cytokine control of megakaryopoiesis.

Growth Factors 2018 08 15;36(3-4):89-103. Epub 2018 Oct 15.

a The Walter and Eliza Hall Institute of Medical Research , Parkville , Australia.

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http://dx.doi.org/10.1080/08977194.2018.1498487DOI Listing
August 2018

The combination of reduced MCL-1 and standard chemotherapeutics is tolerable in mice.

Cell Death Differ 2017 12 11;24(12):2032-2043. Epub 2017 Aug 11.

Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.

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http://dx.doi.org/10.1038/cdd.2017.125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686343PMC
December 2017

ROBUST HYPERPARAMETER ESTIMATION PROTECTS AGAINST HYPERVARIABLE GENES AND IMPROVES POWER TO DETECT DIFFERENTIAL EXPRESSION.

Ann Appl Stat 2016 Jun 22;10(2):946-963. Epub 2016 Jul 22.

The Walter and Eliza Hall Institute of Medical Research; The University of Melbourne.

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http://projecteuclid.org/euclid.aoas/1469199900
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http://dx.doi.org/10.1214/16-AOAS920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373812PMC
June 2016

Haematopoietic stem cells: past, present and future.

Cell Death Discov 2017 6;3:17002. Epub 2017 Feb 6.

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, Australia; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia.

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http://dx.doi.org/10.1038/cddiscovery.2017.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292770PMC
February 2017

The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis.

Immunity 2016 09 11;45(3):513-526. Epub 2016 Aug 11.

The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, Victoria 3050, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2016.07.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040700PMC
September 2016

Runx1 downregulates stem cell and megakaryocytic transcription programs that support niche interactions.

Blood 2016 06 13;127(26):3369-81. Epub 2016 Apr 13.

Retroviral Pathogenesis, Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany;

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http://dx.doi.org/10.1182/blood-2015-09-668129DOI Listing
June 2016

In vivo at last: Demonstrating the biological credentials and clinical potential of GM-CSF.

Exp Hematol 2016 Aug 1;44(8):669-73. Epub 2016 Feb 1.

Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia; Department of Medical Biology, University of Melbourne, Victoria, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2016.01.006DOI Listing
August 2016

Acute myeloid leukemia requires Hhex to enable PRC2-mediated epigenetic repression of Cdkn2a.

Genes Dev 2016 Jan;30(1):78-91

Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, Victoria 3050, Australia;

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http://dx.doi.org/10.1101/gad.268425.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701980PMC
January 2016

Necroptosis signalling is tuned by phosphorylation of MLKL residues outside the pseudokinase domain activation loop.

Biochem J 2015 Oct 17;471(2):255-65. Epub 2015 Aug 17.

The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia Department of Medical Biology, University of Melbourne, Parkville, Victoria 3050, Australia

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http://dx.doi.org/10.1042/BJ20150678DOI Listing
October 2015

Polycomb repressive complex 2 component Suz12 is required for hematopoietic stem cell function and lymphopoiesis.

Blood 2015 Jul 2;126(2):167-75. Epub 2015 Jun 2.

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; Department of Medical Biology and.

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http://dx.doi.org/10.1182/blood-2014-12-615898DOI Listing
July 2015

Mouse prenatal platelet-forming lineages share a core transcriptional program but divergent dependence on MPL.

Blood 2015 Aug 20;126(6):807-16. Epub 2015 May 20.

Molecular Medicine Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia; and Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1182/blood-2014-12-616607DOI Listing
August 2015

Early lineage priming by trisomy of Erg leads to myeloproliferation in a Down syndrome model.

PLoS Genet 2015 May 14;11(5):e1005211. Epub 2015 May 14.

The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1371/journal.pgen.1005211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431731PMC
May 2015

Brief Report: Factors Released by Megakaryocytes Thrombin Cleave Osteopontin to Negatively Regulate Hematopoietic Stem Cells.

Stem Cells 2015 Jul 15;33(7):2351-7. Epub 2015 May 15.

Manufacturing Flagship, Commonwealth Scientific and Industrial Research Organization, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1002/stem.2038DOI Listing
July 2015

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL.

Nat Commun 2015 Feb 18;6:6282. Epub 2015 Feb 18.

1] Inflammation Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia [2] Department of Medical Biology, the University of Melbourne, Parkville, Victoria 3050, Australia.

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http://dx.doi.org/10.1038/ncomms7282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346630PMC
February 2015

Jarid2 regulates hematopoietic stem cell function by acting with polycomb repressive complex 2.

Blood 2015 Mar 2;125(12):1890-900. Epub 2015 Feb 2.

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia;

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http://dx.doi.org/10.1182/blood-2014-10-603969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424268PMC
March 2015

Key role of suppressor of cytokine signaling 3 in regulating gp130 cytokine-induced signaling and limiting chondrocyte responses during murine inflammatory arthritis.

Arthritis Rheumatol 2014 Sep;66(9):2391-402

The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia and University of Melbourne, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1002/art.38701DOI Listing
September 2014

Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation.

Proc Natl Acad Sci U S A 2014 Apr 7;111(16):5884-9. Epub 2014 Apr 7.

Divisions of Cancer and Haematology, and Molecular Medicine, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.

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http://dx.doi.org/10.1073/pnas.1404354111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000844PMC
April 2014

Functional characterization of c-Mpl ectodomain mutations that underlie congenital amegakaryocytic thrombocytopenia.

Growth Factors 2014 Feb 20;32(1):18-26. Epub 2014 Jan 20.

The Walter and Eliza Hall Institute of Medical Research , Parkville, Victoria , Australia and.

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http://dx.doi.org/10.3109/08977194.2013.874347DOI Listing
February 2014

Transgenic expression of GM-CSF in T cells causes disseminated histiocytosis.

Am J Pathol 2014 Jan 30;184(1):184-99. Epub 2013 Oct 30.

Inflammation Division, the Reid Rheumatology Laboratory, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia; Department of Medical Biology, University of Melbourne, Parkville, Australia; Rheumatology Unit, Melbourne Health, PO Royal Melbourne Hospital, Parkville, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029440130066
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http://dx.doi.org/10.1016/j.ajpath.2013.09.014DOI Listing
January 2014

The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism.

Immunity 2013 Sep 5;39(3):443-53. Epub 2013 Sep 5.

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3050, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2013.06.018DOI Listing
September 2013

Polycomb repressive complex 2 (PRC2) suppresses Eμ-myc lymphoma.

Blood 2013 Oct 27;122(15):2654-63. Epub 2013 Aug 27.

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; and.

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http://dx.doi.org/10.1182/blood-2013-02-484055DOI Listing
October 2013

Lymphotoxin α induces apoptosis, necroptosis and inflammatory signals with the same potency as tumour necrosis factor.

FEBS J 2013 Nov 2;280(21):5283-97. Epub 2013 Aug 2.

The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia; Department of Medical Biology, University of Melbourne, Parkville, Australia.

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http://dx.doi.org/10.1111/febs.12419DOI Listing
November 2013

Epigenetic regulator Smchd1 functions as a tumor suppressor.

Cancer Res 2013 Mar 26;73(5):1591-9. Epub 2012 Dec 26.

The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-3019DOI Listing
March 2013

Hematopoietic overexpression of the transcription factor Erg induces lymphoid and erythro-megakaryocytic leukemia.

Proc Natl Acad Sci U S A 2012 Sep 30;109(38):15437-42. Epub 2012 Aug 30.

Cancer and Hematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, VIC, Australia.

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http://dx.doi.org/10.1073/pnas.1213454109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458381PMC
September 2012

Characterization of thrombopoietin (TPO)-responsive progenitor cells in adult mouse bone marrow with in vivo megakaryocyte and erythroid potential.

Proc Natl Acad Sci U S A 2012 Feb 30;109(7):2364-9. Epub 2012 Jan 30.

The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1073/pnas.1121385109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289343PMC
February 2012

Thrombocytopenia and erythrocytosis in mice with a mutation in the gene encoding the hemoglobin β minor chain.

Proc Natl Acad Sci U S A 2012 Jan 27;109(2):576-81. Epub 2011 Dec 27.

Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, 3052, Australia.

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http://dx.doi.org/10.1073/pnas.1119146109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258592PMC
January 2012

SOCS3 deletion in B cells alters cytokine responses and germinal center output.

J Immunol 2011 Dec 9;187(12):6318-26. Epub 2011 Nov 9.

Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.4049/jimmunol.1102057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3254674PMC
December 2011

Erg is required for self-renewal of hematopoietic stem cells during stress hematopoiesis in mice.

Blood 2011 Sep 14;118(9):2454-61. Epub 2011 Jun 14.

Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.

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http://dx.doi.org/10.1182/blood-2011-03-344739DOI Listing
September 2011

Mouse models of diseases of megakaryocyte and platelet homeostasis.

Mamm Genome 2011 Aug 11;22(7-8):449-65. Epub 2011 Jun 11.

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.

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http://link.springer.com/10.1007/s00335-011-9336-4
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http://dx.doi.org/10.1007/s00335-011-9336-4DOI Listing
August 2011

Gastrin-deficient mice have disturbed hematopoiesis in response to iron deficiency.

Endocrinology 2011 Aug 7;152(8):3062-73. Epub 2011 Jun 7.

University of Melbourne Department of Surgery, Austin Health, Heidelberg, Victoria 3084, Australia.

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http://dx.doi.org/10.1210/en.2010-1474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3138233PMC
August 2011

IL-6 promotes acute and chronic inflammatory disease in the absence of SOCS3.

Immunol Cell Biol 2012 Jan 26;90(1):124-9. Epub 2011 Apr 26.

Department of Inflammation, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.

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http://doi.wiley.com/10.1038/icb.2011.29
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http://dx.doi.org/10.1038/icb.2011.29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146962PMC
January 2012

Regulation of hematopoietic stem cells by their mature progeny.

Proc Natl Acad Sci U S A 2010 Dec 29;107(50):21689-94. Epub 2010 Nov 29.

Molecular Medicine Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1016166108
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http://dx.doi.org/10.1073/pnas.1016166108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003054PMC
December 2010

SOCS3 regulates graft-versus-host disease.

Blood 2010 Jul 30;116(2):287-96. Epub 2010 Apr 30.

The Queensland Institute of Medical Research, 300 Herston Rd., Brisbane, Queensland 4006, Australia.

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http://dx.doi.org/10.1182/blood-2009-12-259598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910612PMC
July 2010

Trisomy of Erg is required for myeloproliferation in a mouse model of Down syndrome.

Blood 2010 May 9;115(19):3966-9. Epub 2009 Dec 9.

Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.

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http://dx.doi.org/10.1182/blood-2009-09-242107DOI Listing
May 2010

Regulation of multiple cytokine signalling pathways by SOCS3 is independent of SOCS2.

Growth Factors 2009 Dec;27(6):384-93

Division of Cancer and Haematology, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, 3050, Australia.

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http://dx.doi.org/10.3109/08977190903210954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412171PMC
December 2009

SOCS-1 binding to tyrosine 441 of IFN-gamma receptor subunit 1 contributes to the attenuation of IFN-gamma signaling in vivo.

J Immunol 2009 Oct 4;183(7):4537-44. Epub 2009 Sep 4.

Signal Transduction Laboratory, St Vincent's Institute, 9 Princes Street, Fitzroy, Victoria 3065, Australia.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.0901010
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http://dx.doi.org/10.4049/jimmunol.0901010DOI Listing
October 2009

Dual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage.

Proc Natl Acad Sci U S A 2009 Aug 31;106(33):13814-9. Epub 2009 Jul 31.

Divisions of Molecular Medicine and Cancer and Haematology, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3052, Australia.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0906556106
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http://dx.doi.org/10.1073/pnas.0906556106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728977PMC
August 2009

Mutational inhibition of c-Myb or p300 ameliorates treatment-induced thrombocytopenia.

Blood 2009 May 27;113(22):5599-604. Epub 2009 Feb 27.

Molecular Medicine Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.

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http://dx.doi.org/10.1182/blood-2008-12-195255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689056PMC
May 2009

Platelets kill intraerythrocytic malarial parasites and mediate survival to infection.

Science 2009 Feb;323(5915):797-800

Menzies Research Institute, University of Tasmania, Private Bag 23, Hobart, Tasmania 7000, Australia.

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http://dx.doi.org/10.1126/science.1166296DOI Listing
February 2009

Hematopoietic defects in the Ts1Cje mouse model of Down syndrome.

Blood 2009 Feb 24;113(9):1929-37. Epub 2008 Dec 24.

Molecular Medicine, Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2008-06-16
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http://dx.doi.org/10.1182/blood-2008-06-161422DOI Listing
February 2009

The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells.

Nat Immunol 2008 Jul 25;9(7):810-9. Epub 2008 May 25.

Division of Molecular Medicine, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia.

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http://dx.doi.org/10.1038/ni.1617DOI Listing
July 2008

Socs3 maintains the specificity of biological responses to cytokine signals during granulocyte and macrophage differentiation.

Exp Hematol 2008 Jul 8;36(7):786-98. Epub 2008 Apr 8.

Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1016/j.exphem.2008.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2556307PMC
July 2008

Critical role of thrombopoietin in maintaining adult quiescent hematopoietic stem cells.

Cell Stem Cell 2007 Dec 20;1(6):671-84. Epub 2007 Nov 20.

Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, 221 84, Sweden.

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http://dx.doi.org/10.1016/j.stem.2007.10.008DOI Listing
December 2007

Perturbed thymopoiesis in vitro in the absence of suppressor of cytokine signalling 1 and 3.

Mol Immunol 2008 May 5;45(10):2888-96. Epub 2008 Mar 5.

Signal Transduction Laboratory, St Vincent's Institute, 9 Princes Street, Fitzroy, Victoria 3065, Australia.

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http://dx.doi.org/10.1016/j.molimm.2008.01.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291229PMC
May 2008

Mechanism of crosstalk inhibition of IL-6 signaling in response to LPS and TNFalpha.

Growth Factors 2007 Oct;25(5):319-28

Division of Cancer and Hematology, The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic., Australia.

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http://dx.doi.org/10.1080/08977190701830151DOI Listing
October 2007

Clonogenic mast cell progenitors and their excess numbers in chimeric BALB/c mice with inactivated GATA-1.

Proc Natl Acad Sci U S A 2007 Nov 13;104(47):18642-7. Epub 2007 Nov 13.

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3050, Victoria, Australia.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0709625104
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http://dx.doi.org/10.1073/pnas.0709625104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2141830PMC
November 2007

Mice rendered severely deficient in megakaryocytes through targeted gene deletion of the thrombopoietin receptor c-Mpl have a normal skeletal phenotype.

Calcif Tissue Int 2007 Sep 4;81(3):224-31. Epub 2007 Aug 4.

Anatomy and Clinical Sciences North Bristol, University of Bristol, Southwell Street, Bristol, BS2 8EJ, UK.

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http://dx.doi.org/10.1007/s00223-007-9051-zDOI Listing
September 2007