Warren J Leonard

Warren J Leonard

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Warren J Leonard

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Fine-Tuning Cytokine Signals.

Annu Rev Immunol 2019 Apr 16;37:295-324. Epub 2019 Jan 16.

Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-1674, USA; email: ,

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https://www.annualreviews.org/doi/10.1146/annurev-immunol-04
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http://dx.doi.org/10.1146/annurev-immunol-042718-041447DOI Listing
April 2019

IL-21/type I interferon interplay regulates neutrophil-dependent innate immune responses to .

Elife 2019 Apr 16;8. Epub 2019 Apr 16.

Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, United States.

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http://dx.doi.org/10.7554/eLife.45501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504231PMC
April 2019

The γ Family of Cytokines: Basic Biology to Therapeutic Ramifications.

Immunity 2019 Apr;50(4):832-850

Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Metabolic, and Skin Diseases, National Institutes of Health, Bethesda, MD 20892-1674, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10747613193014
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http://dx.doi.org/10.1016/j.immuni.2019.03.028DOI Listing
April 2019

Defective IgA response to atypical intestinal commensals in IL-21 receptor deficiency reshapes immune cell homeostasis and mucosal immunity.

Mucosal Immunol 2019 01 7;12(1):85-96. Epub 2018 Aug 7.

Mucosal Immunobiology Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/s41385-018-0056-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301133PMC
January 2019

Chromatin Accessibility and Interactions in the Transcriptional Regulation of T Cells.

Front Immunol 2018 22;9:2738. Epub 2018 Nov 22.

Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States.

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http://dx.doi.org/10.3389/fimmu.2018.02738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262064PMC
November 2018

Biology and regulation of IL-2: from molecular mechanisms to human therapy.

Nat Rev Immunol 2018 Oct;18(10):648-659

Laboratory of Molecular Immunology and The Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/s41577-018-0046-yDOI Listing
October 2018

The Common Cytokine Receptor γ Chain Family of Cytokines.

Cold Spring Harb Perspect Biol 2018 Sep 4;10(9). Epub 2018 Sep 4.

Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-1674.

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http://dx.doi.org/10.1101/cshperspect.a028449DOI Listing
September 2018

Biology of IL-2 and its therapeutic modulation: Mechanisms and strategies.

J Leukoc Biol 2018 04 9;103(4):643-655. Epub 2018 Mar 9.

Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1002/JLB.2RI0717-278RDOI Listing
April 2018

TSLP signaling in CD4 T cells programs a pathogenic T helper 2 cell state.

Sci Signal 2018 Mar 13;11(521). Epub 2018 Mar 13.

Division of Immunobiology and the Center for Systems Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1126/scisignal.aam8858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039124PMC
March 2018

STAT5-mediated chromatin interactions in superenhancers activate IL-2 highly inducible genes: Functional dissection of the gene locus.

Proc Natl Acad Sci U S A 2017 11 24;114(46):12111-12119. Epub 2017 Oct 24.

Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health (NIH), Bethesda, MD 20892;

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http://dx.doi.org/10.1073/pnas.1714019114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699083PMC
November 2017

Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells.

Nat Commun 2017 11 6;8(1):1320. Epub 2017 Nov 6.

Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, 20892-1674, USA.

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http://dx.doi.org/10.1038/s41467-017-01477-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673064PMC
November 2017

The γ  family of cytokines: fine-tuning signals from IL-2 and IL-21 in the regulation of the immune response.

F1000Res 2017 23;6:1872. Epub 2017 Oct 23.

Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.12688/f1000research.12202.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657018PMC
October 2017

Genetic background-dependent role of for eyelid development.

Proc Natl Acad Sci U S A 2017 08 4;114(34):E7131-E7139. Epub 2017 Aug 4.

Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892;

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http://dx.doi.org/10.1073/pnas.1705848114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576810PMC
August 2017

Molecular Models of STAT5A Tetramers Complexed to DNA Predict Relative Genome-Wide Frequencies of the Spacing between the Two Dimer Binding Motifs of the Tetramer Binding Sites.

PLoS One 2016 18;11(8):e0160339. Epub 2016 Aug 18.

Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20892-4264, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0160339PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990345PMC
July 2017

Skin-derived TSLP systemically expands regulatory T cells.

J Autoimmun 2017 May 23;79:39-52. Epub 2017 Jan 23.

Department of Pathology & Laboratory Medicine, University of Pennsylvania, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2017.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386815PMC
May 2017

A TSLP-complement axis mediates neutrophil killing of methicillin-resistant .

Sci Immunol 2016 Nov;1(5)

Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1674, USA.

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http://dx.doi.org/10.1126/sciimmunol.aaf8471DOI Listing
November 2016

Cutting Edge: IL-4, IL-21, and IFN-γ Interact To Govern T-bet and CD11c Expression in TLR-Activated B Cells.

J Immunol 2016 08 18;197(4):1023-8. Epub 2016 Jul 18.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;

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http://dx.doi.org/10.4049/jimmunol.1600522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975960PMC
August 2016

Interleukin-21 signaling in B cells, but not in T cells, is indispensable for the development of collagen-induced arthritis in mice.

Arthritis Res Ther 2016 08 17;18:188. Epub 2016 Aug 17.

Division of Host Defense, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi Higashi-ku, Fukuoka, 812-8582, Japan.

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http://dx.doi.org/10.1186/s13075-016-1086-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989522PMC
August 2016

Immunology: JAK3 inhibition—is it sufficient?

Nat Chem Biol 2016 May;12(5):308-10

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May 2016

Endothelial interleukin-21 receptor up-regulation in peripheral artery disease.

Vasc Med 2016 Apr 24;21(2):99-104. Epub 2015 Dec 24.

Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, USA Division of Cardiovascular Medicine, Department of Medicine, University of Virginia, Charlottesville, VA, USA

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http://dx.doi.org/10.1177/1358863X15621798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347532PMC
April 2016

Cutting Edge: Expression of IRF8 in Gastric Epithelial Cells Confers Protective Innate Immunity against Helicobacter pylori Infection.

J Immunol 2016 Mar 3;196(5):1999-2003. Epub 2016 Feb 3.

Virology and Cellular Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852;

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http://dx.doi.org/10.4049/jimmunol.1500766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761481PMC
March 2016

IL-21 Signaling in Immunity.

F1000Res 2016 26;5. Epub 2016 Feb 26.

Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethseda, Maryland, 20892, USA.

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http://dx.doi.org/10.12688/f1000research.7634.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770986PMC
March 2016

T Follicular Helper Cell Plasticity Shapes Pathogenic T Helper 2 Cell-Mediated Immunity to Inhaled House Dust Mite.

Immunity 2016 Feb 26;44(2):259-73. Epub 2016 Jan 26.

Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2015.11.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758890PMC
February 2016

Cutting Edge: IL-1 Receptor Signaling is Critical for the Development of Autoimmune Uveitis.

J Immunol 2016 Jan 7;196(2):543-6. Epub 2015 Dec 7.

Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892; and

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http://dx.doi.org/10.4049/jimmunol.1502080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707108PMC
January 2016

New insights into heterogeneity of peritoneal B-1a cells.

Ann N Y Acad Sci 2015 Dec 18;1362:68-76. Epub 2015 May 18.

The Virology and Cellular Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland.

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http://dx.doi.org/10.1111/nyas.12791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651667PMC
December 2015

William E. Paul, MD (1936-2015).

Trends Immunol 2015 Dec;36(12):751-3

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December 2015

William E. Paul, M.D. (1936–2015).

Immunity 2015 Oct;43(4):617-9

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October 2015

Possible Human Papillomavirus 38 Contamination of Endometrial Cancer RNA Sequencing Samples in The Cancer Genome Atlas Database.

J Virol 2015 Sep 17;89(17):8967-73. Epub 2015 Jun 17.

Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA

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http://jvi.asm.org/lookup/doi/10.1128/JVI.00822-15
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http://dx.doi.org/10.1128/JVI.00822-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524064PMC
September 2015

Comprehensive assembly of novel transcripts from unmapped human RNA-Seq data and their association with cancer.

Mol Syst Biol 2015 Aug 7;11(8):826. Epub 2015 Aug 7.

Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute National Institutes of Health, Bethesda, MD, USA

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562499PMC
http://dx.doi.org/10.15252/msb.156172DOI Listing
August 2015

IL-21-mediated non-canonical pathway for IL-1β production in conventional dendritic cells.

Nat Commun 2015 Aug 13;6:7988. Epub 2015 Aug 13.

Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung and Blood Institute, National Institutes of Health, 10 Center Drive, Building 10, Room 7B05, Bethesda, Maryland 20892-1674 USA.

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http://dx.doi.org/10.1038/ncomms8988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555999PMC
August 2015

Opposing roles of STAT1 and STAT3 in IL-21 function in CD4+ T cells.

Proc Natl Acad Sci U S A 2015 Jul 13;112(30):9394-9. Epub 2015 Jul 13.

Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1674;

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http://dx.doi.org/10.1073/pnas.1511711112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522759PMC
July 2015

Loss of interleukin-21 receptor activation in hypoxic endothelial cells impairs perfusion recovery after hindlimb ischemia.

Arterioscler Thromb Vasc Biol 2015 May 2;35(5):1218-25. Epub 2015 Apr 2.

From the Robert M. Berne Cardiovascular Research Center (T.W., A.C., A.O.D., S.H., K.H., L.C., R.J.L., B.H.A.) and Division of Cardiovascular Medicine, Department of Medicine (S.H., B.H.A.), University of Virginia, Charlottesville; and Laboratory of Molecular Immunology and the Immunology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD (R.S., W.J.L.).

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http://dx.doi.org/10.1161/ATVBAHA.115.305476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865891PMC
May 2015

Thymic stromal lymphopoietin and interleukin-4 mediate the pathogenesis of halothane-induced liver injury in mice.

Hepatology 2014 Nov 20;60(5):1741-52. Epub 2014 May 20.

Molecular and Cellular Toxicology Section, Laboratory of Molecular Immunology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1002/hep.27169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451830PMC
November 2014

EGR2 is critical for peripheral naïve T-cell differentiation and the T-cell response to influenza.

Proc Natl Acad Sci U S A 2014 Nov 3;111(46):16484-9. Epub 2014 Nov 3.

Laboratory of Molecular Immunology and Immunology Center, and

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http://dx.doi.org/10.1073/pnas.1417215111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246296PMC
November 2014

Potential role of myeloid cell/eosinophil-derived IL-17 in LPS-induced endotoxin shock.

Biochem Biophys Res Commun 2014 Oct 6;453(1):1-6. Epub 2014 Sep 6.

Laboratory of Systems Biology, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan; Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency, Saitama 332-0012, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2014.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250284PMC
October 2014

Complex interactions of transcription factors in mediating cytokine biology in T cells.

Immunol Rev 2014 Sep;261(1):141-56

Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1111/imr.12199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174316PMC
September 2014

Autoimmunity: regulatory B cells--IL-35 and IL-21 regulate the regulators.

Nat Rev Rheumatol 2014 Aug 17;10(8):452-3. Epub 2014 Jun 17.

Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 208921674, USA.

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http://www.nature.com/articles/nrrheum.2014.95
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http://dx.doi.org/10.1038/nrrheum.2014.95DOI Listing
August 2014

Interleukin-21: a double-edged sword with therapeutic potential.

Nat Rev Drug Discov 2014 May 22;13(5):379-95. Epub 2014 Apr 22.

Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute (NHLBI), US National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/nrd4296DOI Listing
May 2014

Opposing actions of IL-2 and IL-21 on Th9 differentiation correlate with their differential regulation of BCL6 expression.

Proc Natl Acad Sci U S A 2014 Mar 18;111(9):3508-13. Epub 2014 Feb 18.

Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1674.

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http://dx.doi.org/10.1073/pnas.1301138111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948278PMC
March 2014

A profibrotic role for thymic stromal lymphopoietin in systemic sclerosis.

Ann Rheum Dis 2013 Dec 14;72(12):2018-23. Epub 2013 Feb 14.

Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (i+12), , Madrid, Spain.

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http://dx.doi.org/10.1136/annrheumdis-2012-202279DOI Listing
December 2013

Enhanced T cell lymphoma in NOD.Stat5b transgenic mice is caused by hyperactivation of Stat5b in CD8+ thymocytes.

PLoS One 2013 14;8(2):e56600. Epub 2013 Feb 14.

Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Georgia Regents University, Augusta, Georgia, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0056600PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572980PMC
August 2013

Excessive Th1 responses due to the absence of TGF-β signaling cause autoimmune diabetes and dysregulated Treg cell homeostasis.

Proc Natl Acad Sci U S A 2013 Apr 8;110(17):6961-6. Epub 2013 Apr 8.

Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.

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http://dx.doi.org/10.1073/pnas.1304498110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637710PMC
April 2013

The cytokines IL-21 and GM-CSF have opposing regulatory roles in the apoptosis of conventional dendritic cells.

Immunity 2013 Mar 28;38(3):514-27. Epub 2013 Feb 28.

Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1674, USA.

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http://dx.doi.org/10.1016/j.immuni.2013.02.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705920PMC
March 2013

Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy.

Immunity 2013 Jan;38(1):13-25

Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1674, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S10747613130001
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http://dx.doi.org/10.1016/j.immuni.2013.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610532PMC
January 2013

Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15.

Nat Immunol 2012 Dec 28;13(12):1187-95. Epub 2012 Oct 28.

Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California, USA.

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http://dx.doi.org/10.1038/ni.2449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501574PMC
December 2012

TSLP: A Key Regulator of Asthma Pathogenesis.

Drug Discov Today Dis Mech 2012 Dec;9(3-4)

Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1674, USA.

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http://dx.doi.org/10.1016/j.ddmec.2012.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859144PMC
December 2012

BATF-JUN is critical for IRF4-mediated transcription in T cells.

Nature 2012 Oct 19;490(7421):543-6. Epub 2012 Sep 19.

Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-1674, USA.

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http://dx.doi.org/10.1038/nature11530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537508PMC
October 2012

Th17 cell-derived IL-17 is dispensable for B cell antibody production.

Cytokine 2012 Jul 13;59(1):108-14. Epub 2012 Apr 13.

Department of Medical Genomics, Graduate School of Frontier Sciences, The University of Tokyo, Chiba 277-8561, Japan.

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http://dx.doi.org/10.1016/j.cyto.2012.03.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746348PMC
July 2012

Cd14 SNPs regulate the innate immune response.

Mol Immunol 2012 Jun 23;51(2):112-27. Epub 2012 Mar 23.

Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1016/j.molimm.2012.02.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341513PMC
June 2012

Critical Role of STAT5 transcription factor tetramerization for cytokine responses and normal immune function.

Immunity 2012 Apr;36(4):586-99

Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1674, USA.

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http://dx.doi.org/10.1016/j.immuni.2012.02.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551341PMC
April 2012

Unusual timing of CD127 expression by mouse uterine natural killer cells.

J Leukoc Biol 2012 Mar 6;91(3):417-26. Epub 2012 Jan 6.

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 25 Orde St., Toronto, ON, Canada.

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http://dx.doi.org/10.1189/jlb.1011501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289395PMC
March 2012

IL-21 promotes the pathologic immune response to pneumovirus infection.

J Immunol 2012 Feb 11;188(4):1924-32. Epub 2012 Jan 11.

Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.4049/jimmunol.1100767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277853PMC
February 2012

IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation.

Curr Opin Immunol 2011 Oct 31;23(5):598-604. Epub 2011 Aug 31.

Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1674, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S095279151100106
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http://dx.doi.org/10.1016/j.coi.2011.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405730PMC
October 2011

Thymic stromal lymphopoietin is produced by dendritic cells.

J Immunol 2011 Aug 20;187(3):1207-11. Epub 2011 Jun 20.

Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.4049/jimmunol.1100355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140600PMC
August 2011

Role of thymic stromal lymphopoietin (TSLP) in palifermin-mediated immune modulation and protection from acute murine graft-versus-host disease.

J Clin Immunol 2011 Jun 15;31(3):406-13. Epub 2010 Dec 15.

Department of Pathology, Faculty of Medicine, University of Manitoba, 401 Brodie Center, 727 McDermot Avenue, Winnipeg, MB, Canada.

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http://link.springer.com/10.1007/s10875-010-9491-5
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http://dx.doi.org/10.1007/s10875-010-9491-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3133792PMC
June 2011

Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages.

Nat Immunol 2011 Jun 24;12(6):551-9. Epub 2011 Apr 24.

Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1038/ni.2030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3304099PMC
June 2011

p90RSK2 is essential for FLT3-ITD- but dispensable for BCR-ABL-induced myeloid leukemia.

Blood 2011 Jun 28;117(25):6885-94. Epub 2011 Apr 28.

Department of Hematology and Medical Oncology, Emory University School of Medicine, Winship Cancer Institute of Emory, Atlanta, GA, USA.

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http://dx.doi.org/10.1182/blood-2010-10-315721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128480PMC
June 2011

IL-13 induces skin fibrosis in atopic dermatitis by thymic stromal lymphopoietin.

J Immunol 2011 Jun 16;186(12):7232-42. Epub 2011 May 16.

Division of Allergy and Clinical Immunology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.4049/jimmunol.1100504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399513PMC
June 2011

Key role for IL-21 in experimental autoimmune uveitis.

Proc Natl Acad Sci U S A 2011 Jun 18;108(23):9542-7. Epub 2011 May 18.

Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.1018182108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111309PMC
June 2011

Analysis of the role of IL-21 in development of murine B cell progenitors in the bone marrow.

J Immunol 2011 May 23;186(9):5244-53. Epub 2011 Mar 23.

Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, Ontario M5G 2M9, Canada.

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http://dx.doi.org/10.4049/jimmunol.1004040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080450PMC
May 2011

Thymic stromal lymphopoietin is a key mediator of breast cancer progression.

J Immunol 2011 May 13;186(10):5656-62. Epub 2011 Apr 13.

Immunotherapeutics Unit, Laboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.4049/jimmunol.1100463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401482PMC
May 2011

IL-21 is an immune activator that also mediates suppression via IL-10.

Crit Rev Immunol 2010 ;30(6):559-70

Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, Bethesda, MD 20892-1674, USA.

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January 2011

Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling.

Proc Natl Acad Sci U S A 2010 Nov 25;107(45):19455-60. Epub 2010 Oct 25.

Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1674, USA.

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http://dx.doi.org/10.1073/pnas.1008271107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2984176PMC
November 2010

Cutting edge: spontaneous development of IL-17-producing gamma delta T cells in the thymus occurs via a TGF-beta 1-dependent mechanism.

J Immunol 2010 Feb 8;184(4):1675-9. Epub 2010 Jan 8.

Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.

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http://dx.doi.org/10.4049/jimmunol.0903539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844788PMC
February 2010

IL-21 and T follicular helper cells.

Int Immunol 2010 Jan 23;22(1):7-12. Epub 2009 Nov 23.

Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, Bethesda, MD 20892-1674, USA.

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http://dx.doi.org/10.1093/intimm/dxp112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795365PMC
January 2010

IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells.

Proc Natl Acad Sci U S A 2009 Aug 29;106(32):13463-8. Epub 2009 Jul 29.

Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.0906988106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726336PMC
August 2009

New insights into the regulation of T cells by gamma(c) family cytokines.

Nat Rev Immunol 2009 Jul;9(7):480-90

National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-1674, USA.

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http://www.nature.com/articles/nri2580
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http://dx.doi.org/10.1038/nri2580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814538PMC
July 2009

IL-21 mediates suppressive effects via its induction of IL-10.

J Immunol 2009 Mar;182(5):2859-67

Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.4049/jimmunol.0802978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756221PMC
March 2009

Cytokine mediators of Th17 function.

Eur J Immunol 2009 Mar;39(3):658-61

Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethsda, MD, USA.

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http://doi.wiley.com/10.1002/eji.200839066
Publisher Site
http://dx.doi.org/10.1002/eji.200839066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735233PMC
March 2009