Publications by authors named "Warren C W Chan"

100Publications

DNA-Controlled Encapsulation of Small Molecules in Protein Nanoparticles.

J Am Chem Soc 2020 Oct 6;142(42):17938-17943. Epub 2020 Oct 6.

Institute of Biomedical Engineering, University of Toronto, 164 College Street, Toronto, Ontario M5S 3G9, Canada.

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http://dx.doi.org/10.1021/jacs.0c09914DOI Listing
October 2020

A framework for designing delivery systems.

Nat Nanotechnol 2020 Oct 7;15(10):819-829. Epub 2020 Sep 7.

Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/s41565-020-0759-5DOI Listing
October 2020

The dose threshold for nanoparticle tumour delivery.

Nat Mater 2020 Aug 10. Epub 2020 Aug 10.

Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/s41563-020-0755-zDOI Listing
August 2020

Suppressing Subcapsular Sinus Macrophages Enhances Transport of Nanovaccines to Lymph Node Follicles for Robust Humoral Immunity.

ACS Nano 2020 08 12;14(8):9478-9490. Epub 2020 Jun 12.

Institute of Biomaterials & Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada.

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http://dx.doi.org/10.1021/acsnano.0c02240DOI Listing
August 2020

Flow Rate Affects Nanoparticle Uptake into Endothelial Cells.

Adv Mater 2020 Jun 8;32(24):e1906274. Epub 2020 May 8.

Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, M5S 3G9, Canada.

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http://dx.doi.org/10.1002/adma.201906274DOI Listing
June 2020

An Analysis of the Binding Function and Structural Organization of the Protein Corona.

J Am Chem Soc 2020 May 28;142(19):8827-8836. Epub 2020 Apr 28.

Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada.

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http://dx.doi.org/10.1021/jacs.0c01853DOI Listing
May 2020

Nano Research for COVID-19.

Authors:
Warren C W Chan

ACS Nano 2020 04 31;14(4):3719-3720. Epub 2020 Mar 31.

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http://dx.doi.org/10.1021/acsnano.0c02540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123821PMC
April 2020

Diagnosing COVID-19: The Disease and Tools for Detection.

ACS Nano 2020 04 30;14(4):3822-3835. Epub 2020 Mar 30.

Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada.

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http://dx.doi.org/10.1021/acsnano.0c02624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144809PMC
April 2020

Tunable and precise miniature lithium heater for point-of-care applications.

Proc Natl Acad Sci U S A 2020 03 18;117(9):4632-4641. Epub 2020 Feb 18.

Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada;

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http://dx.doi.org/10.1073/pnas.1916562117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060698PMC
March 2020

Liposome Imaging in Optically Cleared Tissues.

Nano Lett 2020 02 22;20(2):1362-1369. Epub 2020 Jan 22.

Institute of Biomaterials and Biomedical Engineering , University of Toronto , 164 College Street , Toronto , Ontario M5S 3G9 , Canada.

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http://dx.doi.org/10.1021/acs.nanolett.9b04853DOI Listing
February 2020

Endothelialized collagen based pseudo-islets enables tuneable subcutaneous diabetes therapy.

Biomaterials 2020 02 26;232:119710. Epub 2019 Dec 26.

Institute of Biomaterial and Biomedical Engineering, University of Toronto, Toronto, M5S 3G9, Canada; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, M5S 3G9, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2019.119710DOI Listing
February 2020

Nanoparticle Size Influences Antigen Retention and Presentation in Lymph Node Follicles for Humoral Immunity.

Nano Lett 2019 10 17;19(10):7226-7235. Epub 2019 Sep 17.

Institute of Biomaterials & Biomedical Engineering , University of Toronto , Toronto , Ontario M5S 3G9 , Canada.

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https://pubs.acs.org/doi/10.1021/acs.nanolett.9b02834
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http://dx.doi.org/10.1021/acs.nanolett.9b02834DOI Listing
October 2019

Engineering Steps for Mobile Point-of-Care Diagnostic Devices.

Acc Chem Res 2019 09 20;52(9):2406-2414. Epub 2019 Aug 20.

Institute of Biomaterials and Biomedical Engineering (IBBME) , University of Toronto , 164 College St , Toronto , ON M5S 3G9 , Canada.

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https://pubs.acs.org/doi/10.1021/acs.accounts.9b00200
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http://dx.doi.org/10.1021/acs.accounts.9b00200DOI Listing
September 2019

Assessing micrometastases as a target for nanoparticles using 3D microscopy and machine learning.

Proc Natl Acad Sci U S A 2019 07 8;116(30):14937-14946. Epub 2019 Jul 8.

Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada;

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http://dx.doi.org/10.1073/pnas.1907646116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660785PMC
July 2019

Supervised Learning and Mass Spectrometry Predicts the Fate of Nanomaterials.

ACS Nano 2019 07 3;13(7):8023-8034. Epub 2019 Jul 3.

Institute of Biomaterials and Biomedical Engineering , University of Toronto , 164 College Street , Toronto , Ontario M5S 3G9 , Canada.

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http://dx.doi.org/10.1021/acsnano.9b02774DOI Listing
July 2019

Characterizing the protein corona of sub-10 nm nanoparticles.

J Control Release 2019 06 17;304:102-110. Epub 2019 Apr 17.

Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON M5S 3H6, Canada; Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Room 230, Toronto, ON M5S 3E1, Canada; Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College St, Toronto, ON M5S 3G9, Canada; Department of Chemical Engineering, University of Toronto, 200 College Street, Toronto, ON M5S 3E5, Canada; Department of Material Science and Engineering, University of Toronto, 160 College Street, Room 450, Toronto M5S 3E1, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01683659193022
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http://dx.doi.org/10.1016/j.jconrel.2019.04.023DOI Listing
June 2019

Elimination Pathways of Nanoparticles.

ACS Nano 2019 05 26;13(5):5785-5798. Epub 2019 Apr 26.

Institute of Biomaterials and Biomedical Engineering , University of Toronto , Toronto , Ontario M5S 3G9 , Canada.

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http://dx.doi.org/10.1021/acsnano.9b01383DOI Listing
May 2019

Synthesis of Patient-Specific Nanomaterials.

Nano Lett 2019 01 28;19(1):116-123. Epub 2018 Dec 28.

Institute of Biomaterials and Biomedical Engineering , University of Toronto , Rosebrugh Building, Room 407, 164 College Street , Toronto , Ontario M5S 3G9 , Canada.

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http://dx.doi.org/10.1021/acs.nanolett.8b03434DOI Listing
January 2019

Quantifying the Ligand-Coated Nanoparticle Delivery to Cancer Cells in Solid Tumors.

ACS Nano 2018 08 26;12(8):8423-8435. Epub 2018 Jul 26.

Institute of Biomaterials and Biomedical Engineering , University of Toronto , 164 College Street , Toronto , Ontario M5S 3G9 , Canada.

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http://dx.doi.org/10.1021/acsnano.8b03900DOI Listing
August 2018

Effect of removing Kupffer cells on nanoparticle tumor delivery.

Proc Natl Acad Sci U S A 2017 12 5;114(51):E10871-E10880. Epub 2017 Dec 5.

Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada;

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http://dx.doi.org/10.1073/pnas.1713390114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754793PMC
December 2017

Simplifying Assays by Tableting Reagents.

J Am Chem Soc 2017 12 27;139(48):17341-17349. Epub 2017 Nov 27.

Institute of Biomaterials and Biomedical Engineering, ‡Terrence Donnelly Centre for Cellular and Bimolecular Research, §Department of Chemistry, ∥Department of Chemical Engineering, and ⊥Department of Materials Science and Engineering, University of Toronto , 160 College Street, Toronto, Ontario, Canada M5S 3E1.

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http://dx.doi.org/10.1021/jacs.7b07055DOI Listing
December 2017

The Role of Nanoparticle Design in Determining Analytical Performance of Lateral Flow Immunoassays.

Nano Lett 2017 12 15;17(12):7207-7212. Epub 2017 Nov 15.

Department of Mechanical Engineering, University of Minnesota , 111 Church Street SE, Minneapolis, Minnesota 55455, United States.

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http://dx.doi.org/10.1021/acs.nanolett.7b02302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747258PMC
December 2017

Nanomedicine 2.0.

Authors:
Warren C W Chan

Acc Chem Res 2017 03;50(3):627-632

Institute of Biomaterials and Biomedical Engineering, Donnelly Center for Cellular and Biomolecular Research, Department of Chemistry, Department of Chemical Engineering, and Department of Materials Science and Engineering, University of Toronto , 160 College Street, 407, Toronto, Ontario M5S 3G9 Canada.

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http://dx.doi.org/10.1021/acs.accounts.6b00629DOI Listing
March 2017

State of diagnosing infectious pathogens using colloidal nanomaterials.

Biomaterials 2017 Nov 17;146:97-114. Epub 2017 Aug 17.

Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada; Terrence Donnelly Centre for Cellular and Bimolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada; Department of Chemistry, University of Toronto, Toronto, Ontario M5S 3H6, Canada; Department of Chemical Engineering, University of Toronto, Toronto, Ontario M5S 3E5, Canada; Department of Materials Science and Engineering, University of Toronto, Toronto, Ontario M5S 3E4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2017.08.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7124370PMC
November 2017

Making vessels more permeable.

Nat Biomed Eng 2017 Aug;1(8):629-631

Institute of Biomaterials and Biomedical Engineering, Rosebrugh Building, Room 407, 164 College Street, Toronto, Ontario, M5S 3G9, Canada.

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http://dx.doi.org/10.1038/s41551-017-0123-8DOI Listing
August 2017

Three-Dimensional Imaging of Transparent Tissues via Metal Nanoparticle Labeling.

J Am Chem Soc 2017 07 13;139(29):9961-9971. Epub 2017 Jul 13.

Institute of Biomaterials and Biomedical Engineering, University of Toronto , Rosebrugh Building, Room 407, 164 College Street, Toronto, Ontario M5S 3G9, Canada.

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http://dx.doi.org/10.1021/jacs.7b04022DOI Listing
July 2017

Peptide-MHC-based nanomedicines for autoimmunity function as T-cell receptor microclustering devices.

Nat Nanotechnol 2017 07 24;12(7):701-710. Epub 2017 Apr 24.

Julia McFarlane Diabetes Research Centre (JMDRC) and Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada.

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http://dx.doi.org/10.1038/nnano.2017.56DOI Listing
July 2017

Diverse Applications of Nanomedicine.

ACS Nano 2017 03 14;11(3):2313-2381. Epub 2017 Mar 14.

CIC biomaGUNE , Paseo de Miramón 182, 20014, Donostia - San Sebastián, Spain.

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http://dx.doi.org/10.1021/acsnano.6b06040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371978PMC
March 2017

Yeast Populations Evolve to Resist CdSe Quantum Dot Toxicity.

Bioconjug Chem 2017 04 16;28(4):1205-1213. Epub 2017 Feb 16.

Institute of Biomaterials and Biomedical Engineering, Donnelly Center for Cellular and Biomolecular Research, Chemistry, Chemical Engineering, University of Toronto , 160 College Street, Toronto, Ontario M5S 3G9, Canada.

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http://dx.doi.org/10.1021/acs.bioconjchem.7b00056DOI Listing
April 2017

Phenotype Determines Nanoparticle Uptake by Human Macrophages from Liver and Blood.

ACS Nano 2017 03 17;11(3):2428-2443. Epub 2017 Jan 17.

Multi Organ Transplant Program, Toronto General Research Institute, University Health Network , 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4.

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http://dx.doi.org/10.1021/acsnano.6b06245DOI Listing
March 2017

Clarifying intact 3D tissues on a microfluidic chip for high-throughput structural analysis.

Proc Natl Acad Sci U S A 2016 Dec 12;113(52):14915-14920. Epub 2016 Dec 12.

Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada M5S 3G9;

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http://dx.doi.org/10.1073/pnas.1609569114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206515PMC
December 2016

Controlling DNA-nanoparticle serum interactions.

Proc Natl Acad Sci U S A 2016 11 16;113(48):13600-13605. Epub 2016 Nov 16.

Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada M5S 3G9;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1610028113
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http://dx.doi.org/10.1073/pnas.1610028113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137734PMC
November 2016

Exploring Passive Clearing for 3D Optical Imaging of Nanoparticles in Intact Tissues.

Bioconjug Chem 2017 01 5;28(1):253-259. Epub 2016 Dec 5.

Institute of Biomaterials and Biomedical Engineering , Rosebrugh Building, Room 407, 164 College Street, Toronto, Ontario M5S 3G9, Canada.

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http://dx.doi.org/10.1021/acs.bioconjchem.6b00500DOI Listing
January 2017

Mechanism of hard-nanomaterial clearance by the liver.

Nat Mater 2016 11 15;15(11):1212-1221. Epub 2016 Aug 15.

Institute of Biomaterials and Biomedical Engineering, University of Toronto, Rosebrugh Building, Room 407, 164 College Street, Toronto, Ontario M5S 3G9, Canada.

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http://dx.doi.org/10.1038/nmat4718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5132626PMC
November 2016

Thermal Contrast Amplification Reader Yielding 8-Fold Analytical Improvement for Disease Detection with Lateral Flow Assays.

Anal Chem 2016 12 7;88(23):11774-11782. Epub 2016 Nov 7.

Department of Mechanical Engineering, University of Minnesota - Twin Cities , Minneapolis, Minnesota 55455, United States.

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http://dx.doi.org/10.1021/acs.analchem.6b03406DOI Listing
December 2016

Patients, Here Comes More Nanotechnology.

ACS Nano 2016 09 30;10(9):8139-42. Epub 2016 Aug 30.

Fachbereich Physik, Philipps Universität Marburg , Marburg D-35032, Germany.

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http://dx.doi.org/10.1021/acsnano.6b05610DOI Listing
September 2016

Tuning the Drug Loading and Release of DNA-Assembled Gold-Nanorod Superstructures.

Adv Mater 2016 Oct 9;28(38):8511-8518. Epub 2016 Aug 9.

Department of Material Science and Engineering, University of Toronto, Toronto, M5S 3E1, Canada.

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http://dx.doi.org/10.1002/adma.201600773DOI Listing
October 2016

Quantitative Comparison of Photothermal Heat Generation between Gold Nanospheres and Nanorods.

Sci Rep 2016 07 21;6:29836. Epub 2016 Jul 21.

Department of Mechanical Engineering, University of Minnesota, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1038/srep29836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956767PMC
July 2016

Highly efficient adenoviral transduction of pancreatic islets using a microfluidic device.

Lab Chip 2016 08 5;16(15):2921-34. Epub 2016 Jul 5.

Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College St., Toronto, Ontario M5S 3G9, Canada.

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http://dx.doi.org/10.1039/c6lc00345aDOI Listing
August 2016

A versatile plasmonic thermogel for disinfection of antimicrobial resistant bacteria.

Biomaterials 2016 08 22;97:154-63. Epub 2016 Apr 22.

Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College St. 407, Toronto, ON, Canada; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 164 College St. 407, Toronto, ON, Canada; Chemistry, University of Toronto, 164 College St. 407, Toronto, ON, Canada; Chemical Engineering, University of Toronto, 164 College St. 407, Toronto, ON, Canada; Materials Science and Engineering, University of Toronto, 164 College St. 407, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2016.04.009DOI Listing
August 2016

Three-Dimensional Optical Mapping of Nanoparticle Distribution in Intact Tissues.

ACS Nano 2016 05 28;10(5):5468-78. Epub 2016 Apr 28.

Institute of Biomaterials and Biomedical Engineering, University of Toronto , Rosebrugh Building, Room 407, 164 College Street, Toronto, Ontario M5S 3G9, Canada.

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http://dx.doi.org/10.1021/acsnano.6b01879DOI Listing
May 2016

Clinical Validation of Quantum Dot Barcode Diagnostic Technology.

ACS Nano 2016 04 14;10(4):4742-53. Epub 2016 Apr 14.

Institute of Biomaterials and Biomedical Engineering, University of Toronto , Toronto, Ontario M5S 3G9, Canada.

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http://dx.doi.org/10.1021/acsnano.6b01254DOI Listing
April 2016

Engineering the Structure and Properties of DNA-Nanoparticle Superstructures Using Polyvalent Counterions.

J Am Chem Soc 2016 Apr 28;138(13):4565-72. Epub 2016 Mar 28.

Institute of Biomaterials and Biomedical Engineering, Rosebrugh Building , Room 407, 164 College Street, Toronto, Ontario M5S 3G9, Canada.

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http://dx.doi.org/10.1021/jacs.6b00751DOI Listing
April 2016

DNA-controlled dynamic colloidal nanoparticle systems for mediating cellular interaction.

Science 2016 Feb;351(6275):841-5

Institute of Biomaterials and Biomedical Engineering, Donnelly Center for Cellular and Biomolecular Research, University of Toronto, 164 College Street, Toronto, ON M5S 3G9, Canada. Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON M5S 3H6, Canada. Department of Chemical Engineering, University of Toronto, 200 College Street, Toronto, ON M5S 3E5, Canada. Department of Material Science and Engineering, University of Toronto, 160 College Street, Room 450, University of Toronto, Toronto, ON M5S 3E1, Canada.

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https://tspace.library.utoronto.ca/bitstream/1807/73441/1/DN
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http://dx.doi.org/10.1126/science.aad4925DOI Listing
February 2016

Tailoring nanoparticle designs to target cancer based on tumor pathophysiology.

Proc Natl Acad Sci U S A 2016 Mar 16;113(9):E1142-51. Epub 2016 Feb 16.

Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada M5S 3G9; Donnelly Center for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada M5S 3E1; Department of Chemistry, University of Toronto, ON, Canada M5S 3H6; Department of Chemical Engineering, University of Toronto, ON, Canada M5S 3E5; Department of Materials Science and Engineering, University of Toronto, ON, Canada M5S 3E4

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http://dx.doi.org/10.1073/pnas.1521265113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780626PMC
March 2016

Nanoparticle-blood interactions: the implications on solid tumour targeting.

Chem Commun (Camb) 2015 Feb;51(14):2756-67

Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College Street, Toronto, ON M5S 3G9, Canada. and Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 164 College Street, Toronto, ON M5S 3G9, Canada and Chemistry, University of Toronto, 164 College Street, Toronto, ON M5S 3G9, Canada and Chemical Engineering, University of Toronto, 164 College Street, Toronto, ON M5S 3G9, Canada and Materials Science and Engineering, University of Toronto, 164 College Street, Toronto, ON M5S 3G9, Canada.

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http://dx.doi.org/10.1039/c4cc07644cDOI Listing
February 2015

Improving nanoparticle diffusion through tumor collagen matrix by photo-thermal gold nanorods.

Nanoscale 2016 Jul 29;8(25):12524-30. Epub 2016 Jan 29.

Department of Material Science and Engineering, University of Toronto, Toronto M5S 3E1, Canada.

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http://dx.doi.org/10.1039/c5nr08463fDOI Listing
July 2016

Nanoparticle-liver interactions: Cellular uptake and hepatobiliary elimination.

J Control Release 2016 10 13;240:332-348. Epub 2016 Jan 13.

Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College Street, Toronto, ON M5S 3G9, Canada; Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 164 College Street, Toronto, ON M5S 3G9, Canada; Department of Chemistry, University of Toronto, 164 College Street, Toronto, ON M5S 3G9, Canada; Department of Chemical Engineering & Applied Chemistry, University of Toronto, 164 College Street, Toronto, ON M5S 3G9, Canada; Department of Materials Science and Engineering, University of Toronto, 164 College Street, Toronto, ON M5S 3G9, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2016.01.020DOI Listing
October 2016

Prediction of nanoparticles-cell association based on corona proteins and physicochemical properties.

Nanoscale 2015 Jun;7(21):9664-75

Center for Environmental Implications of Nanotechnology, University of California, Los Angeles, CA90095, USA.

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http://dx.doi.org/10.1039/c5nr01537eDOI Listing
June 2015

How nanoparticles interact with cancer cells.

Cancer Treat Res 2015 ;166:227-44

Institute of Biomaterials and Biomedical Engineering, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 164 College St., 407, Toronto, ON, M5S 3G9, Canada.

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http://dx.doi.org/10.1007/978-3-319-16555-4_10DOI Listing
July 2015

Integrated quantum dot barcode smartphone optical device for wireless multiplexed diagnosis of infected patients.

ACS Nano 2015 Mar 16;9(3):3060-74. Epub 2015 Feb 16.

†Institute of Biomaterials and Biomedical Engineering, ‡Terrence Donnelly Centre for Cellular and Biomolecular Research, Departments of §Chemistry, ∥Chemical Engineering, ⊥Materials Science and Engineering, #Department of Immunology, ¶Laboratory Medicine and Pathobiology, and △Sandra Rotman Centre for Global Health, University of Toronto, 160 College Street, Toronto, ON M5S 3E1, Canada.

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http://dx.doi.org/10.1021/nn5072792DOI Listing
March 2015

The role of ligand density and size in mediating quantum dot nuclear transport.

Small 2014 Oct 2;10(20):4182-92. Epub 2014 Jul 2.

Institute of Biomaterials and Biomedical Engineering, Donnelly Center for Cellular and Biomolecular Research, Chemistry, Chemical Engineering, Materials Science and Engineering, University of Toronto, 160 College St., 4th Floor, Toronto, ON, M5S 3G9, Canada.

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http://dx.doi.org/10.1002/smll.201401056DOI Listing
October 2014

Nanoparticle exposure in animals can be visualized in the skin and analysed via skin biopsy.

Nat Commun 2014 May 13;5:3796. Epub 2014 May 13.

1] Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada M5S3G9 [2] Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada M5S3E1 [3] Department of Chemical Engineering, University of Toronto, Toronto, Ontario, Canada M5S3E5 [4] Department of Chemistry, University of Toronto, Toronto, Ontario, Canada M5S3H6 [5] Department of Material Science and Engineering, University of Toronto, Toronto, Ontario, Canada M5S3E4.

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http://dx.doi.org/10.1038/ncomms4796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071057PMC
May 2014

Investigating the impact of nanoparticle size on active and passive tumor targeting efficiency.

ACS Nano 2014 Jun 22;8(6):5696-706. Epub 2014 May 22.

Institute of Biomaterials and Biomedical Engineering, ‡Donnelly Centre for Cellular and Biomolecular Research, §Department of Chemical Engineering, ¶Department of Chemistry, ⊥Department of Material Science and Engineering, and ∥Department of Medical Biophysics, University of Toronto , Toronto, Canada M5S 3G9.

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http://dx.doi.org/10.1021/nn500299pDOI Listing
June 2014

Secreted biomolecules alter the biological identity and cellular interactions of nanoparticles.

ACS Nano 2014 Jun 14;8(6):5515-26. Epub 2014 May 14.

Institute of Biomaterials and Biomedical Engineering, University of Toronto , Toronto, Ontario M5R 0A3, Canada.

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http://dx.doi.org/10.1021/nn4061012DOI Listing
June 2014

Polyethylene glycol backfilling mitigates the negative impact of the protein corona on nanoparticle cell targeting.

Angew Chem Int Ed Engl 2014 May 2;53(20):5093-6. Epub 2014 Apr 2.

Institute of Biomaterials and Biomedical Engineering; Terrence Donnelly Center for Cellular and Biomolecular Research; Department of Chemistry, Materials Science and Engineering; and Department of Chemical Engineering University of Toronto, Toronto, M5S 3G9 (Canada).

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http://dx.doi.org/10.1002/anie.201309464DOI Listing
May 2014

Some food for thought on nanoeducation.

ACS Nano 2014 Feb;8(2):1075-7

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http://dx.doi.org/10.1021/nn500808mDOI Listing
February 2014

Protein corona fingerprinting predicts the cellular interaction of gold and silver nanoparticles.

ACS Nano 2014 Mar 25;8(3):2439-55. Epub 2014 Feb 25.

Institute of Biomaterials and Biomedical Engineering, ‡Banting and Best Department of Medical Research, §Donnelly Centre for Cellular and Biomolecular Research, ⊥Department of Chemical Engineering, ∥Department of Chemistry, #Department of Materials Science and Engineering, University of Toronto , Toronto, Ontario, Canada M5S 3G9.

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March 2014

DNA assembly of nanoparticle superstructures for controlled biological delivery and elimination.

Nat Nanotechnol 2014 Feb 26;9(2):148-55. Epub 2014 Jan 26.

1] Institute of Biomaterials and Biomedical Engineering, Rosebrugh Building, Room 407, 164 College Street, Toronto, Ontario M5S 3G9, Canada [2] Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Room 230, Toronto, Ontario M5S 3E1, Canada [3] Department of Chemical Engineering, 200 College Street, Toronto, Ontario M5S 3E5, Canada [4] Department of Chemistry, 80 St George Street, Toronto, Ontario M5S 3H6, Canada [5] Department of Material Science and Engineering, 160 College Street, Room 450, University of Toronto, Toronto M5S 3E1, Canada.

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http://dx.doi.org/10.1038/nnano.2013.309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947377PMC
February 2014

Tumour-on-a-chip provides an optical window into nanoparticle tissue transport.

Nat Commun 2013 ;4:2718

1] Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada [2] Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada [3].

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http://dx.doi.org/10.1038/ncomms3718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947376PMC
July 2014

Bioimaging: illuminating the deep.

Nat Mater 2013 Apr;12(4):285-7

Institute of Biomaterials and Biomedical Engineering, Terrence Donnelly Centre for Cellular and Biomolecular Research, Department of Chemical Engineering, Materials Science and Engineering, and Chemistry, Toronto, Ontario, Canada.

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April 2013

Automating quantum dot barcode assays using microfluidics and magnetism for the development of a point-of-care device.

ACS Appl Mater Interfaces 2013 Apr 25;5(8):2853-60. Epub 2013 Feb 25.

Institute of Biomaterials and Biomedical Engineering, Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Fourth Floor, Toronto, Ontario M5S 3E1, Canada.

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http://dx.doi.org/10.1021/am302633hDOI Listing
April 2013

A plasmonic DNAzyme strategy for point-of-care genetic detection of infectious pathogens.

Angew Chem Int Ed Engl 2013 Mar 10;52(11):3168-71. Epub 2013 Feb 10.

Institute of Biomaterials and Biomedical Engineering, Terrence Donnelly Centre for Cellular and Biomolecular Research, Chemistry, Chemical Engineering, Materials Science and Engineering, University of Toronto, Toronto, ON M5S3E1, Canada.

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http://doi.wiley.com/10.1002/anie.201208715
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March 2013

Complexities abound.

Authors:
Warren C W Chan

Nat Nanotechnol 2013 Feb;8(2):72-3

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February 2013

Fluorescence-tagged gold nanoparticles for rapidly characterizing the size-dependent biodistribution in tumor models.

Adv Healthc Mater 2012 Nov 20;1(6):714-21. Epub 2012 Aug 20.

Terrence Donnelly Centre for Cellular and Biomolecular Research, Toronto, Ontario, Canada.

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http://doi.wiley.com/10.1002/adhm.201200084
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November 2012

Three-color fluorescence cross-correlation spectroscopy for analyzing complex nanoparticle mixtures.

Anal Chem 2012 Nov 24;84(21):9623-31. Epub 2012 Oct 24.

Department of Chemistry, University of Calgary, 2500 University Drive NW, T3A 0J1, Calgary, Alberta, Canada.

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http://pubs.acs.org/doi/10.1021/ac302572k
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November 2012

Simultaneous quantification of cells and nanomaterials by inductive-coupled plasma techniques.

J Lab Autom 2013 Feb 29;18(1):99-104. Epub 2012 Aug 29.

Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.

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February 2013

Are quantum dots toxic? Exploring the discrepancy between cell culture and animal studies.

Acc Chem Res 2013 Mar 1;46(3):662-71. Epub 2012 Aug 1.

Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, M5S 3G9, Canada.

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http://pubs.acs.org/doi/10.1021/ar300040z
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March 2013

Nonblinking plasmonic quantum dot assemblies for multiplex biological detection.

Angew Chem Int Ed Engl 2012 Aug 29;51(35):8773-7. Epub 2012 Jul 29.

Institute of Biomaterials and Biomedical Engineering, Donnelly Centre for Cellular and Biomolecular Research, Chemical Engineering, Chemistry, Materials Science and Engineering, University of Toronto, Toronto, ON, M5S 3G9 Canada.

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http://dx.doi.org/10.1002/anie.201201872DOI Listing
August 2012

Nanotoxicology. No signs of illness.

Nat Nanotechnol 2012 Jul 4;7(7):416-7. Epub 2012 Jul 4.

University of Toronto, Ontario, ON, Canada.

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http://www.nature.com/articles/nnano.2012.110
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July 2012

The effect of nanoparticle size, shape, and surface chemistry on biological systems.

Annu Rev Biomed Eng 2012 18;14:1-16. Epub 2012 Apr 18.

Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1146/annurev-bioeng-071811-150124DOI Listing
November 2012

Significantly improved analytical sensitivity of lateral flow immunoassays by using thermal contrast.

Angew Chem Int Ed Engl 2012 Apr 23;51(18):4358-61. Epub 2012 Mar 23.

Department of Mechanical Engineering, University of Minnesota, 111 Church St. SE, Minneapolis, MN 55455, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337364PMC
April 2012

The development of direct multicolour fluorescence cross-correlation spectroscopy: towards a new tool for tracking complex biomolecular events in real-time.

Phys Chem Chem Phys 2012 Mar 17;14(10):3290-4. Epub 2012 Jan 17.

Department of Chemistry, University of Calgary, 2500 University Dr NW, Calgary, AB, Canada T2N 1N4.

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http://dx.doi.org/10.1039/c2cp23278bDOI Listing
March 2012

Nanoparticle size and surface chemistry determine serum protein adsorption and macrophage uptake.

J Am Chem Soc 2012 Feb 23;134(4):2139-47. Epub 2012 Jan 23.

Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada M5S 3G9.

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http://pubs.acs.org/doi/10.1021/ja2084338
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February 2012

Principles of conjugating quantum dots to proteins via carbodiimide chemistry.

Nanotechnology 2011 Dec 21;22(49):494006. Epub 2011 Nov 21.

Institute of Biomaterials and Biomedical Engineering, Donelly Center for Cellular and Biomolecular Research, Materials Science and Engineering, Chemical Engineering, Chemistry, University of Toronto, Toronto, ON, M5S 3G9, Canada.

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December 2011

Understanding and controlling the interaction of nanomaterials with proteins in a physiological environment.

Chem Soc Rev 2012 Apr 15;41(7):2780-99. Epub 2011 Nov 15.

Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada.

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April 2012

Effect of gold nanoparticle aggregation on cell uptake and toxicity.

ACS Nano 2011 Jul 21;5(7):5478-89. Epub 2011 Jun 21.

Institute of Biomaterials and Biomedical Engineering, Terrence Donnelly Centre for Cellular and Biomolecular Research, Materials Science and Engineering, University of Toronto, 160 College Street, Toronto, Ontario, Canada.

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http://pubs.acs.org/doi/10.1021/nn2007496
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July 2011

Design and potential application of PEGylated gold nanoparticles with size-dependent permeation through brain microvasculature.

Nanomedicine 2011 Dec 4;7(6):992-1000. Epub 2011 May 4.

The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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December 2011

A strategy to assemble nanoparticles with polymers for mitigating cytotoxicity and enabling size tuning.

Nanomedicine (Lond) 2011 Jul 24;6(5):767-75. Epub 2011 May 24.

Institute of Biomaterials & Biomedical Engineering, Terrence Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.2217/nnm.11.58DOI Listing
July 2011

Porphysome nanovesicles generated by porphyrin bilayers for use as multimodal biophotonic contrast agents.

Nat Mater 2011 Apr 20;10(4):324-32. Epub 2011 Mar 20.

Institute of Biomaterials and Biomedical Engineering, University of Toronto, Ontario M5G 1L7, Canada.

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http://dx.doi.org/10.1038/nmat2986DOI Listing
April 2011

Engineering multifunctional magnetic-quantum dot barcodes by flow focusing.

Chem Commun (Camb) 2011 Apr 2;47(14):4195-7. Epub 2011 Mar 2.

Institute of Biomaterials & Biomedical Engineering & Terrence Donnelly Center for Cellular and Biomolecular Research Chemistry, Chemical Engineering, Materials Science and Engineering, University of Toronto, 160 College Street, 4th floor Toronto, ON M5S 3G9, Canada.

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http://dx.doi.org/10.1039/c0cc05336hDOI Listing
April 2011

Rapid screening of genetic biomarkers of infectious agents using quantum dot barcodes.

ACS Nano 2011 Mar 28;5(3):1580-7. Epub 2011 Feb 28.

Institute of Biomaterials and Biomedical Engineering, Terrence Donnelly Centre for Biomolecular Research, Materials Science and Engineering, Chemical Engineering, Chemistry, University of Toronto, 164 College Street, Toronto, Ontario, M5S 3G9, Canada.

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http://dx.doi.org/10.1021/nn102873wDOI Listing
March 2011

Nanomedicine.

N Engl J Med 2010 Dec;363(25):2434-43

Institute of Biomaterials and Biomedical Engineering, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1056/NEJMra0912273DOI Listing
December 2010

Quantum-dot-encoded microbeads for multiplexed genetic detection of non-amplified DNA samples.

Small 2011 Jan;7(1):137-46

Institute of Biomaterials & Biomedical Engineering, University of Toronto, Toronto, ON, M5S 3G9, Canada.

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http://dx.doi.org/10.1002/smll.201000909DOI Listing
January 2011

Strategies for the intracellular delivery of nanoparticles.

Chem Soc Rev 2011 Jan 30;40(1):233-45. Epub 2010 Sep 30.

Institute of Biomaterials and Biomedical Engineering, Donnelly Center for Cellular and Biomolecular Research, Materials Science and Engineering, Chemical Engineering, Chemistry, University of Toronto, Toronto, ON M5S 3G9, Canada.

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http://dx.doi.org/10.1039/c0cs00003eDOI Listing
January 2011

In vivo assembly of nanoparticle components to improve targeted cancer imaging.

Proc Natl Acad Sci U S A 2010 Jun 7;107(25):11194-9. Epub 2010 Jun 7.

Institute of Biomaterials and Biomedical Engineering, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, ON, Canada M5S 3E1.

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http://dx.doi.org/10.1073/pnas.1001367107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895069PMC
June 2010

Rough around the edges: the inflammatory response of microglial cells to spiky nanoparticles.

ACS Nano 2010 May;4(5):2490-3

Department of Chemical Engineering, Institute of Biomaterials and Biomedical Engineering, University of Toronto, Donnelly Centre for Cellular and Biomolecular Research, Toronto, Ontario M5S 3G9, Canada.

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http://dx.doi.org/10.1021/nn100776zDOI Listing
May 2010

Exploring primary liver macrophages for studying quantum dot interactions with biological systems.

Adv Mater 2010 Jun;22(23):2520-4

Institute of Biomaterials & Biomedical Engineering, University of Toronto, Wallberg Building, Toronto, ON M5S3G9, Canada.

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http://dx.doi.org/10.1002/adma.200904231DOI Listing
June 2010

Application of semiconductor and metal nanostructures in biology and medicine.

Hematology Am Soc Hematol Educ Program 2009 :701-7

Institute of Biomaterials & Biomedical Engineering, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1182/asheducation-2009.1.701DOI Listing
March 2010