Publications by authors named "Wan-Teck Lim"

91Publications

Molecular Characterization and Clinical Outcomes in RET-Rearranged NSCLC.

J Thorac Oncol 2020 Dec 28;15(12):1928-1934. Epub 2020 Aug 28.

Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore; Duke-NUS Medical School, National University of Singapore, Singapore, Singapore. Electronic address:

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December 2020

Single-Cell Analysis of Circulating Tumor Cells: Why Heterogeneity Matters.

Cancers (Basel) 2019 Oct 19;11(10). Epub 2019 Oct 19.

Division of Medical Oncology, National Cancer Centre Singapore, Singapore 169610, Singapore.

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October 2019

Liquid biopsy: one cell at a time.

NPJ Precis Oncol 2019 2;3:23. Epub 2019 Oct 2.

1NUS Graduate School for Integrative Sciences & Engineering, National University of Singapore, Singapore, Singapore.

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October 2019

Compendiums of cancer transcriptomes for machine learning applications.

Sci Data 2019 10 8;6(1):194. Epub 2019 Oct 8.

NUS Graduate School for Integrative Sciences & Engineering, National University of Singapore, Singapore, Singapore.

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October 2019

Addressing cellular heterogeneity in tumor and circulation for refined prognostication.

Proc Natl Acad Sci U S A 2019 09 15;116(36):17957-17962. Epub 2019 Aug 15.

NUS Graduate School for Integrative Sciences & Engineering, National University of Singapore, 117456 Singapore, Singapore;

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September 2019

Pan-cancer analysis connects tumor matrisome to immune response.

NPJ Precis Oncol 2019 22;3:15. Epub 2019 May 22.

1NUS Graduate School for Integrative Sciences & Engineering, National University of Singapore, Singapore, Singapore.

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May 2019

First-line afatinib for the treatment of mutation-positive non-small-cell lung cancer in the 'real-world' clinical setting.

Ther Adv Med Oncol 2019 15;11:1758835919836374. Epub 2019 Apr 15.

Department of Oncology, National Taiwan University Hospital and National Taiwan University Cancer Center, Taipei, Taiwan.

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April 2019

A merged lung cancer transcriptome dataset for clinical predictive modeling.

Sci Data 2018 07 24;5:180136. Epub 2018 Jul 24.

NUS Graduate School for Integrative Sciences & Engineering (NGS), National University of Singapore, #05-01, 28 Medical Drive, Singapore 117456, Singapore.

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July 2018

Antitumor Activity of Nivolumab in Recurrent and Metastatic Nasopharyngeal Carcinoma: An International, Multicenter Study of the Mayo Clinic Phase 2 Consortium (NCI-9742).

J Clin Oncol 2018 05 27;36(14):1412-1418. Epub 2018 Mar 27.

Brigette B.Y. Ma, Edwin P. Hui, Kwok-Wai Lo, Ka-Fai To, K.C. Allen Chan, Y.M. Dennis Lo, Ann D. King, and Anthony T.C. Chan, The Chinese University of Hong Kong, Shatin, Hong Kong, Special Administrative Region, People's Republic of China; Wan-Teck Lim, National Cancer Centre; Boon-Cher Goh, National University Cancer Institute of Singapore; Alex Y.C. Chang, Johns Hopkins University School of Medicine; Akhil Chopra, OncoCare Cancer Centre, Singapore; Adam Pettinger, Nathan R. Foster, Charles Erlichman, Jun Yin, and Brian A. Costello, Mayo Clinic, Rochester, MN; Jonathan W. Riess, University of California Davis Comprehensive Cancer Center, Sacramento; Barbara J. Gitlitz, University of Southern California Keck School of Medicine, Los Angeles; Dean W. Lim, City of Hope Comprehensive Cancer Center, Duarte, CA; Mark Agulnik, Northwestern University, Evanston, IL; Julie A. Kish and Christine H. Chung, Moffitt Cancer Center, University of South Florida, Tampa, FL; Douglas R. Adkins, Washington University School of Medicine, St Louis, MO; Kevin J. Cullen, University of Maryland, Baltimore, MD.

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May 2018

Primary pulmonary lymphoepithelioma-like carcinoma in Singapore.

Ann Thorac Med 2018 Jan-Mar;13(1):30-35

Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore.

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February 2018

An extracellular matrix-related prognostic and predictive indicator for early-stage non-small cell lung cancer.

Nat Commun 2017 11 23;8(1):1734. Epub 2017 Nov 23.

NUS Graduate School for Integrative Sciences & Engineering (NGS), National University of Singapore, #05-01, 28 Medical Drive, Singapore, 117456, Singapore.

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November 2017

Personalized Treatment Through Detection and Monitoring of Genetic Aberrations in Single Circulating Tumor Cells.

Adv Exp Med Biol 2017 ;994:255-273

Mechanobiology Institute of Singapore, 5A Engineering Drive 1, Singapore, 117411, Singapore.

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October 2017

Influence of the KDM4A rs586339 polymorphism on overall survival in Asian non-small-cell lung cancer patients.

Pharmacogenet Genomics 2017 03;27(3):120-123

aLaboratory of Clinical Pharmacology, Division of Medical Sciences, Humphrey Oei Institute of Cancer Research bNational Cancer Centre, Division of Medical Oncology cClinical Pharmacology, SingHealth dDepartment of Clinical Sciences, Duke-NUS Medical School, Singapore.

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March 2017

Metronomic chemotherapy: A relook at its basis and rationale.

Cancer Lett 2017 03 18;388:328-333. Epub 2016 Dec 18.

Division of Medical Oncology, National Cancer Centre, Singapore. Electronic address:

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March 2017

EGFR Mutation Subtypes Influence Survival Outcomes following First-Line Gefitinib Therapy in Advanced Asian NSCLC Patients.

J Thorac Oncol 2017 03 28;12(3):529-538. Epub 2016 Nov 28.

Clinical Pharmacology, SingHealth, Singapore; Laboratory of Clinical Pharmacology, Division of Medical Sciences, Humphrey Oei Institute of Cancer Research, National Cancer Centre, Singapore; Office of Clinical Sciences, Duke-National University of Singapore Medical School, Singapore. Electronic address:

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March 2017

Evaluation of BGJ398, a Fibroblast Growth Factor Receptor 1-3 Kinase Inhibitor, in Patients With Advanced Solid Tumors Harboring Genetic Alterations in Fibroblast Growth Factor Receptors: Results of a Global Phase I, Dose-Escalation and Dose-Expansion Study.

J Clin Oncol 2017 Jan 21;35(2):157-165. Epub 2016 Nov 21.

Lucia Nogova, Reinhard Buettner, and Jürgen Wolf, University Hospital Cologne, Cologne; Martin Schuler, University Hospital Essen, and German Cancer Consortium (DKTK), Essen, Germany; Lecia V. Sequist, Massachusetts General Hospital; Geoffrey I. Shapiro, Dana-Farber Cancer Institute, Boston, MA; Jose Manuel Perez Garcia, Vall d'Hebron Institut d'Oncologia, Barcelona; Manuel Hidalgo, Spanish National Cancer Research Centre, Madrid, Spain; Fabrice Andre, Gustave Roussy, Villejuif; Jean-Pierre Delord, Institute Universitaire du Cancer de Toulouse, Toulouse; Philippe A. Cassier, Centre Regional Leon-Berard, Lyon; Mario Campone, Institute de Cancerologie de l'Ouest-René Gauducheau, Nantes, France; Jan H.M. Schellens, Netherlands Cancer Institute, Amsterdam, and Utrecht University, Utrecht, the Netherlands; D. Ross Camidge, University of Colorado, Aurora, CO; Ulka Vaishampayan, Barbara Ann Karmanos Cancer Institute, Detroit, MI; Howard Burris, Sarah Cannon Research Institute, Nashville; G. Gary Tian, The West Clinic, Memphis, TN; Zev A. Wainberg, UCLA School of Medicine, Los Angeles, CA; Wan-Teck Lim, National Cancer Centre, Singapore; Patricia LoRusso, Yale Cancer Center, New Haven, CT; Katie Parker, Xueying Chen, Somesh Choudhury, and Randi Isaacs, Novartis Pharmaceuticals Corporation, East Hanover, NJ; Dale Porter, Novartis Institutes for Biomedical Research, Cambridge, MA; Francois Ringeisen, Novartis Pharma AG; and Diana Graus-Porta, Novartis Institutes for Biomedical Research, Basel, Switzerland.

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January 2017

Novel therapeutic targets on the horizon for lung cancer.

Lancet Oncol 2016 08;17(8):e347-e362

Division of Medical Oncology, National Cancer Centre Singapore, Singapore; Cancer Therapeutics Research Laboratory, National Cancer Centre Singapore, Singapore; Genome Institute of Singapore, A*STAR, Singapore. Electronic address:

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August 2016

Microfluidic enrichment for the single cell analysis of circulating tumor cells.

Sci Rep 2016 Feb 29;6:22076. Epub 2016 Feb 29.

Department of Biomedical Engineering, National University of Singapore, 4 Engineering Drive 3, Block E4, #04-08, Singapore 117583, Singapore.

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February 2016

Impact of Smoking and Brain Metastasis on Outcomes of Advanced EGFR Mutation Lung Adenocarcinoma Patients Treated with First Line Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors.

PLoS One 2015 8;10(5):e0123587. Epub 2015 May 8.

Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore; Cancer Therapeutics Research Laboratory, Division of Medical Sciences, National Cancer Centre Singapore, Singapore, Singapore; Cancer Stem Cell Biology, Genome Institute of Singapore, Singapore, Singapore.

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February 2016

Do elderly patients benefit from enrollment into Phase I Trials?

J Geriatr Oncol 2015 May 14;6(3):241-8. Epub 2015 Mar 14.

Department of Medical Oncology, National Cancer Centre, Singapore.

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May 2015

Clinical validation of an ultra high-throughput spiral microfluidics for the detection and enrichment of viable circulating tumor cells.

PLoS One 2014 7;9(7):e99409. Epub 2014 Jul 7.

Mechanobiology Institute, National University of Singapore, Singapore, Singapore; BioSystems and Micromechanics (BioSyM) IRG, Singapore-MIT Alliance for Research and Technology (SMART) Centre, Singapore, Singapore; Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore; Clearbridge BioMedics Pte Ltd, Singapore, Singapore.

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November 2015

Trajectory and risk factors for chemotherapy-induced nausea and vomiting in Asian patients with head and neck cancer.

Head Neck 2015 Sep 21;37(9):1349-57. Epub 2014 Jul 21.

Department of Medical Oncology, National Cancer Centre Singapore, Singapore.

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September 2015

Intertumor heterogeneity of non-small-cell lung carcinomas revealed by multiplexed mutation profiling and integrative genomics.

Int J Cancer 2014 Sep 3;135(5):1092-100. Epub 2014 Apr 3.

Department of Medical Oncology, National Cancer Centre, Singapore; Cancer Therapeutics Research Laboratory, National Cancer Centre, Singapore; Cancer Stem Cell Biology, Genome Institute of Singapore, Singapore.

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September 2014

Bosutinib inhibits migration and invasion via ACK1 in KRAS mutant non-small cell lung cancer.

Mol Cancer 2014 Jan 24;13:13. Epub 2014 Jan 24.

Singapore OncoGenome Laboratory, Institute of Medical Biology, Agency of Science Technology and Research, Singapore, Singapore.

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January 2014

Molecular profiling for druggable genetic abnormalities in carcinoma of unknown primary.

J Clin Oncol 2013 May 1;31(14):e237-9. Epub 2013 Apr 1.

Department of Medical Oncology, National Cancer Center Singapore, 11 Hospital Dr, Singapore.

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May 2013

Isolation and retrieval of circulating tumor cells using centrifugal forces.

Sci Rep 2013 12;3:1259. Epub 2013 Feb 12.

Department of Electrical Engineering & Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA.

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August 2013

Influence of SLCO1B3 haplotype-tag SNPs on docetaxel disposition in Chinese nasopharyngeal cancer patients.

Br J Clin Pharmacol 2012 Apr;73(4):606-18

Laboratory of Clinical Pharmacology, Division of Medical Sciences, Humphrey Oei Institute of Cancer Research, National Cancer Centre, 11 Hospital Drive, Singapore.

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April 2012

The effects of CYP3A4, CYP3A5, ABCB1, ABCC2, ABCG2 and SLCO1B3 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of docetaxel in nasopharyngeal carcinoma patients.

Cancer Chemother Pharmacol 2011 Jun 6;67(6):1471-8. Epub 2011 Apr 6.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 10 Medical Drive, Singapore 117597, Singapore.

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June 2011

Versatile label free biochip for the detection of circulating tumor cells from peripheral blood in cancer patients.

Biosens Bioelectron 2010 Dec 22;26(4):1701-5. Epub 2010 Jul 22.

NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, 12 Medical Drive, Singapore 117598, Singapore.

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December 2010

Phase II clinical trials in oncology: are we hitting the target?

Expert Rev Anticancer Ther 2010 Mar;10(3):427-38

National Cancer Centre Singapore, 11 Hospital Drive, Singapore.

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March 2010

Truth about ERCC1 in lung cancer.

J Clin Oncol 2010 Apr 16;28(10):e162; author reply e164. Epub 2010 Feb 16.

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April 2010

Impact of comorbidities on clinical outcomes in non-small cell lung cancer patients who are elderly and/or have poor performance status.

Crit Rev Oncol Hematol 2010 Oct 24;76(1):53-60. Epub 2009 Nov 24.

Department of Medical Oncology, National Cancer Centre Singapore, Singapore.

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October 2010

First-line systemic treatment of advanced stage non-small-cell lung cancer in Asia: consensus statement from the Asian Oncology Summit 2009.

Lancet Oncol 2009 Nov;10(11):1102-10

Department of Haematology-Oncology, National University Hospital, and Cancer Science Institute of Singapore, National University of Singapore, Singapore.

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November 2009

Assessment of human papillomavirus and Epstein-Barr virus in lung adenocarcinoma.

Oncol Rep 2009 Apr;21(4):971-5

Department of Medical Oncology, National Cancer Centre Singapore, Singapore 169610, Republic of Singapore.

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April 2009

Osteoradionecrosis of the cervical spine complicated by pneumocephalus and meningitis in a nasopharyngeal cancer patient radically treated with radiotherapy 11 years ago.

BMJ Case Rep 2009 12;2009. Epub 2009 May 12.

Singapore General Hospital, Singhealth Services, Medical Oncology, National Cancer Centre, 11 Hospital Drive, Singapore, 169610, Singapore.

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November 2011

A Phase I trial of weekly docetaxel and topotecan for solid tumors.

Acta Oncol 2008 ;47(2):311-5

Alvin J Siteman Cancer Center, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA.

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May 2008

Differences between small-cell lung cancer and non-small-cell lung cancer among tobacco smokers.

Lung Cancer 2007 May 31;56(2):161-6. Epub 2007 Jan 31.

Department of Medical Oncology, National Cancer Centre, 11 Hospital Drive, Singapore 169610, Singapore.

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May 2007

Electroacupuncture for refractory acute emesis caused by chemotherapy.

J Altern Complement Med 2006 Dec;12(10):963-9

Department of Medical Oncology, National Cancer Centre, Singapore.

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December 2006

Pharmacogenetics of target genes across the warfarin pharmacological pathway.

Clin Pharmacokinet 2006 ;45(12):1189-200

National Cancer Centre, Laboratory of Clinical Pharmacology, Division of Medical Sciences, Singapore, Singapore.

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February 2007

Paraneoplastic pemphigus resembling linear IgA bullous dermatosis.

Int J Dermatol 2006 Sep;45(9):1093-5

National Skin Centre and Department of Medical Oncology, National Cancer Centre, Singapore.

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September 2006

Lung cancer in never-smokers.

J Clin Pathol 2007 Apr 17;60(4):337-40. Epub 2006 Aug 17.

Department of Medical Oncology, National Cancer Centre, Singapore.

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April 2007

CASE 3. Benign pleural nodules in a patient with esophageal cancer.

J Clin Oncol 2006 Jan;24(3):525

National Cancer Center Singapore, Singapore, Singapore.

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January 2006