Walter J Koch

Walter J Koch

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Walter J Koch

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Aldosterone and Myocardial Pathology.

Vitam Horm 2019 1;109:387-406. Epub 2018 Dec 1.

Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, United States. Electronic address:

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http://dx.doi.org/10.1016/bs.vh.2018.09.005DOI Listing
April 2019

Yap/Taz regulate alveolar regeneration and resolution of lung inflammation.

J Clin Invest 2019 Apr 15;130. Epub 2019 Apr 15.

Department of Pharmacology, Center for Translational Medicine, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1172/JCI125014DOI Listing
April 2019

Echocardiographic Strain Analysis for the Early Detection of Left Ventricular Systolic/Diastolic Dysfunction and Dyssynchrony in a Mouse Model of Physiological Aging.

J Gerontol A Biol Sci Med Sci 2019 Mar;74(4):455-461

Center for Translational Medicine and Department of Pharmacology, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1093/gerona/gly139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417453PMC
March 2019

Sympathetic nervous system in age-related cardiovascular dysfunction: Pathophysiology and therapeutic perspective.

Int J Biochem Cell Biol 2019 Mar 9;108:29-33. Epub 2019 Jan 9.

Center for Translational Medicine and Department of Pharmacology, Lewis Katz School of Medicine, Temple University, Philadelphia, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2019.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383565PMC
March 2019

GRK2 and GRK5 as therapeutic targets and their role in maladaptive and pathological cardiac hypertrophy.

Expert Opin Ther Targets 2019 Mar 13;23(3):201-214. Epub 2019 Feb 13.

a Center for Translational Medicine, Department of Pharmacology, Lewis Katz School of Medicine , Temple University , Philadelphia , PA , USA.

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http://dx.doi.org/10.1080/14728222.2019.1575363DOI Listing
March 2019

Systemic Blockade of ACVR2B Ligands Protects Myocardium from Acute Ischemia-Reperfusion Injury.

Mol Ther 2019 Mar 24;27(3):600-610. Epub 2019 Jan 24.

Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, 90220 Oulu, Finland; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, 90220 Oulu, Finland.

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https://linkinghub.elsevier.com/retrieve/pii/S15250016193001
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http://dx.doi.org/10.1016/j.ymthe.2019.01.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404100PMC
March 2019

Various effects of AAV9-mediated βARKct gene therapy on the heart in dystrophin-deficient (mdx) mice and δ-sarcoglycan-deficient (Sgcd-/-) mice.

Neuromuscul Disord 2019 Mar 20;29(3):231-241. Epub 2018 Dec 20.

Internal Medicine III, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Germany; Department of Internal Medicine III, University of Kiel, Arnold-Heller-Str. 3, 24105 Kiel, Germany.

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http://dx.doi.org/10.1016/j.nmd.2018.12.006DOI Listing
March 2019

Ethyl Pyruvate Modulates Murine Dendritic Cell Activation and Survival Through Their Immunometabolism.

Front Immunol 2019 28;10:30. Epub 2019 Jan 28.

Laboratory of Dendritic Cell Biology, Department of Microbiology-Immunology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, United States.

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http://dx.doi.org/10.3389/fimmu.2019.00030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362406PMC
January 2019

G protein-coupled receptor kinase 2 contributes to impaired fatty acid metabolism in the failing heart.

J Mol Cell Cardiol 2018 Oct 29;123:108-117. Epub 2018 Aug 29.

Center for Translational Medicine, Department of Pharmacology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2018.08.025DOI Listing
October 2018

Pepducin-mediated cardioprotection via β-arrestin-biased β2-adrenergic receptor-specific signaling.

Theranostics 2018 9;8(17):4664-4678. Epub 2018 Sep 9.

Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.

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http://dx.doi.org/10.7150/thno.26619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160776PMC
September 2018

New Insights in Cardiac β-Adrenergic Signaling During Heart Failure and Aging.

Front Pharmacol 2018 10;9:904. Epub 2018 Aug 10.

Department of Pharmacology - Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, United States.

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https://www.frontiersin.org/article/10.3389/fphar.2018.00904
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http://dx.doi.org/10.3389/fphar.2018.00904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095970PMC
August 2018

Designer Approaches for G Protein-Coupled Receptor Modulation for Cardiovascular Disease.

JACC Basic Transl Sci 2018 Aug 28;3(4):550-562. Epub 2018 Aug 28.

Center for Translational Medicine and Department of Pharmacology, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania.

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https://linkinghub.elsevier.com/retrieve/pii/S2452302X173031
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http://dx.doi.org/10.1016/j.jacbts.2017.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115700PMC
August 2018

PH domain leucine-rich repeat protein phosphatase 2 (PHLPP2) regulates G-protein-coupled receptor kinase 5 (GRK5)-induced cardiac hypertrophy .

J Biol Chem 2018 05 8;293(21):8056-8064. Epub 2018 Apr 8.

From the Department of Pharmacology, School of Medicine, University of California San Diego, La Jolla, California 92093 and

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http://dx.doi.org/10.1074/jbc.M117.809913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971445PMC
May 2018

S-Nitrosylation of β-Arrestins Biases Receptor Signaling and Confers Ligand Independence.

Mol Cell 2018 05;70(3):473-487.e6

Institute for Transformative Molecular Medicine, Case Western Reserve University, Cleveland, OH 44106, USA; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2018.03.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940012PMC
May 2018

Long-Term Caloric Restriction Improves Cardiac Function, Remodeling, Adrenergic Responsiveness, and Sympathetic Innervation in a Model of Postischemic Heart Failure.

Circ Heart Fail 2018 Mar;11(3):e004153

From the Division of Geriatrics, Department of Translational Medical Sciences, Federico II University of Naples, Italy (C.d.L., G.G., L.P., A.E., K.K., G.D.F., M.L.D., R.F., D. Liccardo, D. Leosco, N.F., G.R.); Center for Translational Medicine (C.d.L., D. Liccardo, W.J.K.), Department of Pharmacology (C.d.L., D. Liccardo, W.J.K.) and Cardiovascular Research Center (G.B., S.R.H.), Lewis Katz School of Medicine, Temple University, Philadelphia, PA; Salvatore Maugeri Foundation, IRCCS, Scientific Institute of Telese Terme (BN), Italy (G.G., A.E., M.L.D., M.N., N.F., G.R.); and Neurology Imaging Unit, Imperial College London, United Kingdom (G.D.F.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.117.004153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858906PMC
March 2018

GRK2 as negative modulator of NO bioavailability: Implications for cardiovascular disease.

Cell Signal 2018 01 7;41:33-40. Epub 2017 Jan 7.

Center for Translational Medicine and Department of Pharmacology, Lewis Katz School of Medicine, Temple University, Philadelphia, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2017.01.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500446PMC
January 2018

Structural Determinants Influencing the Potency and Selectivity of Indazole-Paroxetine Hybrid G Protein-Coupled Receptor Kinase 2 Inhibitors.

Mol Pharmacol 2017 12 25;92(6):707-717. Epub 2017 Oct 25.

Life Sciences Institute (R.B., H.V.W., M.C.C., J.J.G.T.), Departments of Medicinal Chemistry (H.V.W., S.D.L., J.J.G.T.), Pharmacology (R.B., J.J.G.T.), Biological Chemistry (M.C.C., J.J.G.T.), and Vahlteich Medicinal Chemistry Core, College of Pharmacy (H.V.W., S.D.L.), University of Michigan, Ann Arbor, Michigan; Department of Chemistry, Georgia State University, Atlanta, Georgia (X.-Q.Y.); Center for Translational Medicine, Temple University, Philadelphia, Pennsylvania (A.C., J.S., J.Y.C, W.J.K.); and Department of Biological Sciences, Purdue University, West Lafayette Indiana (J.J.G.T.)

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http://molpharm.aspetjournals.org/lookup/doi/10.1124/mol.117
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http://dx.doi.org/10.1124/mol.117.110130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691592PMC
December 2017

β-Arrestin2 Improves Post-Myocardial Infarction Heart Failure via Sarco(endo)plasmic Reticulum Ca-ATPase-Dependent Positive Inotropy in Cardiomyocytes.

Hypertension 2017 11 5;70(5):972-981. Epub 2017 Sep 5.

From the Laboratory for the Study of Neurohormonal Control of the Circulation, Department of Pharmaceutical Sciences, Nova Southeastern University College of Pharmacy, Fort Lauderdale, FL (K.A.M., J.M., A.V., M.J., C.M., A.B., A.B.-S., S.D., A.L.); and Department of Pharmacology, Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA (W.J.K.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.117.09817DOI Listing
November 2017

Impact of paroxetine on proximal β-adrenergic receptor signaling.

Cell Signal 2017 10 12;38:127-133. Epub 2017 Jul 12.

Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08986568173018
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http://dx.doi.org/10.1016/j.cellsig.2017.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646168PMC
October 2017

Noncanonical Roles of G Protein-coupled Receptor Kinases in Cardiovascular Signaling.

J Cardiovasc Pharmacol 2017 Sep;70(3):129-141

*Department of Pharmacology, Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA; and †Department of Pharmacology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA.

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http://dx.doi.org/10.1097/FJC.0000000000000483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591054PMC
September 2017

Interleukin-10 Inhibits Bone Marrow Fibroblast Progenitor Cell-Mediated Cardiac Fibrosis in Pressure-Overloaded Myocardium.

Circulation 2017 Sep 30;136(10):940-953. Epub 2017 Jun 30.

From Center for Translational Medicine (S.K.V., V.N.S.G., S.M.S., L.A.G., M.C., Z.C., M.K., Y.Y., C.B., M.M.T., J.E.R., D.A.G., D.T., W.J.K., R.K.) and Department of Pharmacology (D.T., W.J.K., R.K.), Lewis Katz School of Medicine, Temple University, Philadelphia, PA; and Department of Biomedical Engineering, School of Medicine, University of Alabama at Birmingham (P.K.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.027889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736130PMC
September 2017

G protein-coupled receptor kinase 2 promotes cardiac hypertrophy.

PLoS One 2017 31;12(7):e0182110. Epub 2017 Jul 31.

Department of Internal Medicine III, Cardiology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0182110PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536362PMC
September 2017

microRNA in Cardiovascular Aging and Age-Related Cardiovascular Diseases.

Front Med (Lausanne) 2017 12;4:74. Epub 2017 Jun 12.

Division of Geriatrics, Department of Translational Medical Sciences, Federico II University of Naples, Naples, Italy.

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http://dx.doi.org/10.3389/fmed.2017.00074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466994PMC
June 2017

Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine.

J Med Chem 2017 04 29;60(7):3052-3069. Epub 2017 Mar 29.

Department of Medicinal Chemistry, College of Pharmacy, ‡Departments of Pharmacology and Biological Chemistry, Life Sciences Institute, §Ph.D. Program in Chemical Biology, ⊥Vahlteich Medicinal Chemistry Core, University of Michigan , Ann Arbor, Michigan 48109, United States.

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http://pubs.acs.org/doi/10.1021/acs.jmedchem.7b00112
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http://dx.doi.org/10.1021/acs.jmedchem.7b00112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641445PMC
April 2017

Targeting β3-Adrenergic Receptors in the Heart: Selective Agonism and β-Blockade.

J Cardiovasc Pharmacol 2017 Feb;69(2):71-78

Department of Pharmacology, Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/FJC.0000000000000444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295490PMC
February 2017

Mitochondrial fusion dynamics is robust in the heart and depends on calcium oscillations and contractile activity.

Proc Natl Acad Sci U S A 2017 01 17;114(5):E859-E868. Epub 2017 Jan 17.

MitoCare Center, Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107;

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http://dx.doi.org/10.1073/pnas.1617288114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293028PMC
January 2017

β2-Adrenergic receptor-dependent chemokine receptor 2 expression regulates leukocyte recruitment to the heart following acute injury.

Proc Natl Acad Sci U S A 2016 12 12;113(52):15126-15131. Epub 2016 Dec 12.

Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140

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http://dx.doi.org/10.1073/pnas.1611023114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206565PMC
December 2016

Skeletal Muscle-specific G Protein-coupled Receptor Kinase 2 Ablation Alters Isolated Skeletal Muscle Mechanics and Enhances Clenbuterol-stimulated Hypertrophy.

J Biol Chem 2016 Oct 26;291(42):21913-21924. Epub 2016 Aug 26.

From the Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania 19140-4106

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http://dx.doi.org/10.1074/jbc.M116.721282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063976PMC
October 2016

Cardiac Fibroblast GRK2 Deletion Enhances Contractility and Remodeling Following Ischemia/Reperfusion Injury.

Circ Res 2016 Oct 6;119(10):1116-1127. Epub 2016 Sep 6.

From the Department of Pharmacology, Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA (M.C.W., B.P.W., E.G., A.Y., W.J.K.); and Department of Cardiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, China (A.Y.).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085864PMC
http://dx.doi.org/10.1161/CIRCRESAHA.116.309538DOI Listing
October 2016

The expanding GRK interactome: Implications in cardiovascular disease and potential for therapeutic development.

Pharmacol Res 2016 08 12;110:52-64. Epub 2016 May 12.

Center for Translational Medicine, Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, United States. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2016.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914454PMC
August 2016

β-arrestin-biased signaling through the β2-adrenergic receptor promotes cardiomyocyte contraction.

Proc Natl Acad Sci U S A 2016 07 27;113(28):E4107-16. Epub 2016 Jun 27.

Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107;

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http://dx.doi.org/10.1073/pnas.1606267113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948363PMC
July 2016

Leukocyte-Expressed β2-Adrenergic Receptors Are Essential for Survival After Acute Myocardial Injury.

Circulation 2016 Jul 30;134(2):153-67. Epub 2016 Jun 30.

From Center for Translational Medicine (L.A.G., A.M.G., C.J.T., J.E.G., A.A.R., E.G., R.L.C., J.E.R., W.J.K., D.G.T.), Department of Pharmacology (E.G., J.E.R., W.J.K., D.G.T.), and Department of Clinical Sciences (D.Y.), Temple University School of Medicine, Philadelphia, PA; Department of Surgery, Division of Cardiothoracic Surgery, Emory University School of Medicine and Carlyle Fraser Heart Center, Atlanta, GA (J.W.C.); and Spanish National Center for Cardiovascular Research, Madrid, Spain (A.P.G., B.I.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.022304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120587PMC
July 2016

Mitochondrial Reactive Oxygen Species Mediate Lysophosphatidylcholine-Induced Endothelial Cell Activation.

Arterioscler Thromb Vasc Biol 2016 06 28;36(6):1090-100. Epub 2016 Apr 28.

From the Centers for Metabolic Disease Research, Cardiovascular Research, Thrombosis Research (X.L., P.F., Y.L., G.N., C.J., H.F., H.S., F.D., S.E., X.J., H.W., X.Y.), Department of Pharmacology (X.L., P.F., Y.L., G.N., C.J., H.F., H.S., F.D., W.J.K., X.J., H.W., X.Y.), Department of Biochemistry (N.E.H., M.M.), Department of Physiology (S.E.), Center for Translational Medicine (N.E.H., M.M., W.J.K.), and Department of Clinical Sciences (D.Y.), Temple University School of Medicine, Philadelphia, PA; Department of Cancer Biology, Fox Chase Cancer Center, Temple University Health System, Philadelphia, PA (Y.-M.K., A.J.A.); and Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA (J.S.).

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http://dx.doi.org/10.1161/ATVBAHA.115.306964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882253PMC
June 2016

Prognostic Value of Lymphocyte G Protein-Coupled Receptor Kinase-2 Protein Levels in Patients With Heart Failure.

Circ Res 2016 Apr 16;118(7):1116-24. Epub 2016 Feb 16.

From the Division of Cardiology, Salvatore Maugeri Foundation, IRCCS, Scientific Institute of Telese Terme (BN), Italy (G.R., G.G., D.F.V., N.F.); Division of Geriatrics, Department of Translational Medical Sciences (G.R., G.P., G.D.F., V.P., A.C., D. Liccardo, K.K., G.G., M.L.D.'A., C.d.L., N.F., D. Leosco), Division of Cardiology, Department of Advanced Biomedical Sciences (P.P.F., B.T.), Federico II University of Naples, Naples, Italy; SDN Foundation IRCCS, Institute of Diagnostic and Nuclear Development, Naples, Italy (S.P.); and Department of Pharmacology, Center of Translational Medicine, Temple University, Philadelphia, PA (A.C., D. Liccardo, W.J.K.).

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http://dx.doi.org/10.1161/CIRCRESAHA.115.308207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818176PMC
April 2016

Structure-activity relationship study of angiotensin II analogs in terms of β-arrestin-dependent signaling to aldosterone production.

Pharmacol Res Perspect 2016 Apr 8;4(2):e00226. Epub 2016 Mar 8.

Department of Pharmaceutical Sciences Laboratory for the Study of Neurohormonal Control of the Circulation Nova Southeastern University College of Pharmacy Fort Lauderdale Florida 33328.

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http://dx.doi.org/10.1002/prp2.226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804318PMC
April 2016

BAG3 regulates contractility and Ca(2+) homeostasis in adult mouse ventricular myocytes.

J Mol Cell Cardiol 2016 Mar 19;92:10-20. Epub 2016 Jan 19.

Center of Translational Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA; Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2016.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789075PMC
March 2016

"Canonical and non-canonical actions of GRK5 in the heart".

J Mol Cell Cardiol 2016 Mar 29;92:196-202. Epub 2016 Jan 29.

Center for Translational Medicine, Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, United States. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2016.01.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789097PMC
March 2016

Myocardial pathology induced by aldosterone is dependent on non-canonical activities of G protein-coupled receptor kinases.

Nat Commun 2016 Mar 2;7:10877. Epub 2016 Mar 2.

Department of Pharmacology and Center for Translational Medicine, Temple University School of Medicine, N. Broad Street, Philadelphia, Pennsylvania 19140, USA.

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http://dx.doi.org/10.1038/ncomms10877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778065PMC
March 2016

c-kit+ Cardiac Stem Cells: Spontaneous Creation or a Perplexing Reality.

Circ Res 2016 Mar;118(5):783-5

From the Center for Translational Medicine (M.K., W.J.K.) and Department of Pharmacology (W.J.K.), Lewis Katz School of Medicine, Temple University, Philadelphia, PA.

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http://dx.doi.org/10.1161/CIRCRESAHA.115.308103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780045PMC
March 2016

A peptide of the RGS domain of GRK2 binds and inhibits Gα(q) to suppress pathological cardiac hypertrophy and dysfunction.

Sci Signal 2016 Mar 22;9(420):ra30. Epub 2016 Mar 22.

Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA. Department of Pharmacology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.

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http://dx.doi.org/10.1126/scisignal.aae0549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015886PMC
March 2016

β Adrenergic Receptor Kinase C-Terminal Peptide Gene-Therapy Improves β2-Adrenergic Receptor-Dependent Neoangiogenesis after Hindlimb Ischemia.

J Pharmacol Exp Ther 2016 Feb 24;356(2):503-13. Epub 2015 Nov 24.

Division of Geriatrics, Department of Translational Medical Sciences, Federico II University of Naples, Italy (A.C., D.Li., G.G., M.L.D.A., D.Le., N.F., G.R.); Center for Translational Medicine, Temple University, Philadelphia, Pennsylvania (A.C., D.Li., W.J.K.); Department of Pharmaceutical Sciences, Nova Southeastern University College of Pharmacy, Fort Lauderdale, Florida (A.L.); Salvatore Maugeri Foundation, IRCCS, Scientific Institute of Telese Terme BN, Italy (F.R., G.R.).

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http://dx.doi.org/10.1124/jpet.115.228411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047230PMC
February 2016

GRK2 compromises cardiomyocyte mitochondrial function by diminishing fatty acid-mediated oxygen consumption and increasing superoxide levels.

J Mol Cell Cardiol 2015 Dec 23;89(Pt B):360-4. Epub 2015 Oct 23.

Center for Translational Medicine & Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2015.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689631PMC
December 2015

Differential Role of G Protein-Coupled Receptor Kinase 5 in Physiological Versus Pathological Cardiac Hypertrophy.

Circ Res 2015 Dec 29;117(12):1001-12. Epub 2015 Oct 29.

From the Center for Translational Medicine, Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA (C.J.T., A.C., A.G.V., B.P.W., J.H., J.I., J.I.G., J.K.C., E.G., W.J.K.); and Department of Biostatistics and Bioinformatics, Fox Chase Cancer Center, Philadelphia, PA (Y.Z.).

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http://dx.doi.org/10.1161/CIRCRESAHA.115.306961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825669PMC
December 2015

Interleukin-10 inhibits chronic angiotensin II-induced pathological autophagy.

J Mol Cell Cardiol 2015 Dec 6;89(Pt B):203-13. Epub 2015 Nov 6.

Center for Translational Medicine, Temple University, Philadelphia 19140, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689660PMC
December 2015

Eating Away at Heart Failure.

J Am Coll Cardiol 2015 Dec;66(22):2534-5

Department of Pharmacology, Center for Translational Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1016/j.jacc.2015.09.085DOI Listing
December 2015

Walter J. Koch: two decades, one mission.

Circ Res 2015 Nov;117(11):917-20

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http://dx.doi.org/10.1161/CIRCRESAHA.115.307772DOI Listing
November 2015

SPG7 Is an Essential and Conserved Component of the Mitochondrial Permeability Transition Pore.

Mol Cell 2015 Oct 17;60(1):47-62. Epub 2015 Sep 17.

Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA 19140, USA; Center for Translational Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA; Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, PA 19140, USA. Electronic address:

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http://linkinghub.elsevier.com/retrieve/pii/S109727651500655
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http://dx.doi.org/10.1016/j.molcel.2015.08.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592475PMC
October 2015

Comparative effects of urocortins and stresscopin on cardiac myocyte contractility.

J Mol Cell Cardiol 2015 Sep 29;86:179-86. Epub 2015 Jul 29.

Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, PA 19140, USA; Department of Physiology, Temple University School of Medicine, Philadelphia, PA 19140, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2015.07.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558371PMC
September 2015

S100A1 DNA-based Inotropic Therapy Protects Against Proarrhythmogenic Ryanodine Receptor 2 Dysfunction.

Mol Ther 2015 Aug 25;23(8):1320-1330. Epub 2015 May 25.

Molecular and Translational Cardiology, Department of Internal Medicine III, Heidelberg University Hospital, Heidelberg, Germany; Center for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA; German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany; uniQure GmbH Germany, Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1038/mt.2015.93DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817858PMC
August 2015

Crystal Structure of G Protein-coupled Receptor Kinase 5 in Complex with a Rationally Designed Inhibitor.

J Biol Chem 2015 Aug 1;290(34):20649-59. Epub 2015 Jun 1.

From the Life Sciences Institute and the Departments of Pharmacology and Biological Sciences, University of Michigan, Ann Arbor, Michigan 48109,

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http://www.jbc.org/content/290/34/20649.full.pdf
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543626PMC
August 2015

AdipoRon, the first orally active adiponectin receptor activator, attenuates postischemic myocardial apoptosis through both AMPK-mediated and AMPK-independent signalings.

Am J Physiol Endocrinol Metab 2015 Aug 2;309(3):E275-82. Epub 2015 Jun 2.

Department of Physiology, Key Laboratory of Cellular Physiology, Ministry of Education, Shanxi Medical University, Taiyuan, China; Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania; and

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http://dx.doi.org/10.1152/ajpendo.00577.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525114PMC
August 2015

Cardiac Dysfunction in HIV-1 Transgenic Mouse: Role of Stress and BAG3.

Clin Transl Sci 2015 Aug 24;8(4):305-10. Epub 2015 Aug 24.

Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1111/cts.12331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841629PMC
August 2015

Embryonic stem cell-derived exosomes promote endogenous repair mechanisms and enhance cardiac function following myocardial infarction.

Circ Res 2015 Jun 22;117(1):52-64. Epub 2015 Apr 22.

From the Center for Translational Medicine (M.K., E.N., J.J., S.K.V., P.K., E.V., V.N.S.G., C.B., E.G., T.L., J.E., W.J.K.), Cardiovascular Research Center (S.R.H.), Department of Physiology (S.R.H.), and Department of Pharmacology (T.L., W.J.K., R.K.), Temple University School of Medicine, Philadelphia, PA; and Feinberg Cardiovascular Research Institute, Northwestern University, Chicago, IL (T.A., A.R.M., E.V., V.R., E.L., A.I., S.M., G.Q., R.K.).

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http://circres.ahajournals.org/content/circresaha/early/2015
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http://dx.doi.org/10.1161/CIRCRESAHA.117.305990DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482130PMC
June 2015

Consequence of the tumor-associated conversion to cyclin D1b.

EMBO Mol Med 2015 May;7(5):628-47

Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA Department of Urology, Thomas Jefferson University, Philadelphia, PA, USA Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, USA

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http://dx.doi.org/10.15252/emmm.201404242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492821PMC
May 2015

G-protein-coupled receptor kinase 2-mediated desensitization of adiponectin receptor 1 in failing heart.

Circulation 2015 Apr 18;131(16):1392-404. Epub 2015 Feb 18.

From Department of Emergency Medicine (Y.W., W.B.L., Y.W., G.L., J.-J.L., X.W., Y.Y., X.-L.M.) and Center for Translational Medicine, Department of Medicine (X.-L.M.), Thomas Jefferson University, Philadelphia, PA; and Center for Translational Medicine, Temple University, Philadelphia, PA (E.G., W.J.K.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.114.015248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406820PMC
April 2015

The evolving impact of g protein-coupled receptor kinases in cardiac health and disease.

Physiol Rev 2015 Apr;95(2):377-404

Center for Translational Medicine and Department of Pharmacology, Temple University School of Medicine, Philadelphia, Pennsylvania; and Advanced Institutes of Convergence Technology, Suwon, South Korea.

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http://dx.doi.org/10.1152/physrev.00015.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551214PMC
April 2015

Ca²⁺ entry via Trpm2 is essential for cardiac myocyte bioenergetics maintenance.

Am J Physiol Heart Circ Physiol 2015 Mar 9;308(6):H637-50. Epub 2015 Jan 9.

Center of Translational Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania; Division of Nephrology, Temple University School of Medicine, Philadelphia, Pennsylvania;

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http://dx.doi.org/10.1152/ajpheart.00720.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360055PMC
March 2015

Paroxetine-mediated GRK2 inhibition reverses cardiac dysfunction and remodeling after myocardial infarction.

Sci Transl Med 2015 Mar;7(277):277ra31

Center for Translational Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA. Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaa0154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768806PMC
March 2015

A microRNA-Hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice.

Sci Transl Med 2015 Mar;7(279):279ra38

Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA19104, USA. Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1126/scitranslmed.3010841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295313PMC
March 2015

Guidelines for translational research in heart failure.

J Cardiovasc Transl Res 2015 Feb 21;8(1):3-22. Epub 2015 Jan 21.

Cardiovascular Development and Repair Department, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Melchor Fernandez Almagro 3, 28029, Madrid, Spain,

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http://dx.doi.org/10.1007/s12265-015-9606-8DOI Listing
February 2015

Suppression of adrenal βarrestin1-dependent aldosterone production by ARBs: head-to-head comparison.

Sci Rep 2015 Jan 29;5:8116. Epub 2015 Jan 29.

Laboratory for the Study of Neurohormonal Control of the Circulation, Department of Pharmaceutical Sciences, Nova Southeastern University College of Pharmacy, Fort Lauderdale, FL 33328, USA.

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http://dx.doi.org/10.1038/srep08116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309955PMC
January 2015

Downregulation of G protein-coupled receptor kinase 2 levels enhances cardiac insulin sensitivity and switches on cardioprotective gene expression patterns.

Biochim Biophys Acta 2014 Dec 18;1842(12 Pt A):2448-56. Epub 2014 Sep 18.

Departamento de Biología Molecular and Centro de Biología Molecular Severo Ochoa (UAM-CSIC), Madrid, Spain; Instituto de Investigación Sanitaria La Princesa, Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2014.09.004DOI Listing
December 2014

GRK5-mediated exacerbation of pathological cardiac hypertrophy involves facilitation of nuclear NFAT activity.

Circ Res 2014 Dec 20;115(12):976-85. Epub 2014 Oct 20.

From the Center for Translational Medicine, Thomas Jefferson University, Philadelphia, PA (J.E.H., J.I.G.); and Center for Translational Medicine (J.E.H., L.A.G., E.G. J.I.G., J.K.C., D.G.T., W.J.K.) and Cardiovascular Research Center (C.A.M., S.R.H.), Temple University School of Medicine, Philadelphia, PA.

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http://dx.doi.org/10.1161/CIRCRESAHA.116.304475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258119PMC
December 2014

GRK2 in the heart: a GPCR kinase and beyond.

Antioxid Redox Signal 2014 Nov 13;21(14):2032-43. Epub 2014 May 13.

Department of Pharmacology and Center for Translational Medicine, Temple University School of Medicine , Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1089/ars.2014.5876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208598PMC
November 2014

β-adrenergic receptor-mediated cardiac contractility is inhibited via vasopressin type 1A-receptor-dependent signaling.

Circulation 2014 Nov 9;130(20):1800-11. Epub 2014 Sep 9.

From the Center for Translational Medicine (D.G.T., E.G., J.S, R.L.C., L.A.G., W.J.K., J.Y.C.), Department of Pharmacology (D.G.T., W.J.K.), Cardiovascular Research Center (W.Z., V.D.M., L.A.B., C.A.M., C.D.T., R.C.C., S.R.H.), Department of Physiology (L.A.B., C.A.M., S.R.H., A.M.F.), Department of Clinical Sciences (D.Y.), and Department of Medicine (J.Y.C., A.M.F.), Temple University School of Medicine, Philadelphia, PA; and the Division of Cardiology, Fourth Military Medical University, Xian, People's Republic of China (X.L.).

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http://circ.ahajournals.org/content/early/2014/09/09/CIRCULA
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http://dx.doi.org/10.1161/CIRCULATIONAHA.114.010434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229385PMC
November 2014

Activation of liver-X-receptor α but not liver-X-receptor β protects against myocardial ischemia/reperfusion injury.

Circ Heart Fail 2014 Nov 2;7(6):1032-41. Epub 2014 Oct 2.

From the Department of Cardiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China (Q.H., J.P., A.Y., B.H.); Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA (W.B.L., X.-L.M.); and Center for Translational Medicine, Temple University School of Medicine, Philadelphia, PA (E.G., W.J.K.).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527689PMC
November 2014

Methods to improve cardiac gene therapy expression.

Expert Rev Cardiovasc Ther 2014 Nov;12(11):1317-26

Temple University, School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1586/14779072.2014.967683DOI Listing
November 2014

Identification and characterization of amlexanox as a G protein-coupled receptor kinase 5 inhibitor.

Molecules 2014 Oct 22;19(10):16937-49. Epub 2014 Oct 22.

Life Sciences Institute and the Departments of Pharmacology and Biological Sciences, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.3390/molecules191016937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621012PMC
October 2014

Adiponectin regulates SR Ca(2+) cycling following ischemia/reperfusion via sphingosine 1-phosphate-CaMKII signaling in mice.

J Mol Cell Cardiol 2014 Sep 20;74:183-92. Epub 2014 May 20.

Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China. Electronic address:

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September 2014

Inhibition of Let-7 microRNA attenuates myocardial remodeling and improves cardiac function postinfarction in mice.

Pharmacol Res Perspect 2014 Aug 12;2(4):e00056. Epub 2014 Jun 12.

Department of Pharmacology and Toxicology, Institute of Biomedicine, University of Oulu Oulu, Finland ; Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, University of Oulu Oulu, Finland.

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http://dx.doi.org/10.1002/prp2.56DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186442PMC
August 2014

Gi proteins mediate activation of the canonical hedgehog pathway in the myocardium.

Am J Physiol Heart Circ Physiol 2014 Jul 9;307(1):H66-72. Epub 2014 May 9.

Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania; Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania

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http://dx.doi.org/10.1152/ajpheart.00166.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080174PMC
July 2014

Apelin receptor: its responsiveness to stretch mechanisms and its potential for cardiovascular therapy.

Expert Rev Cardiovasc Ther 2014 Jun 5;12(6):733-41. Epub 2014 May 5.

Temple University School of Medicine, Philadelphia, PA, USA.

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http://www.tandfonline.com/doi/full/10.1586/14779072.2014.91
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http://dx.doi.org/10.1586/14779072.2014.911661DOI Listing
June 2014

Urotensin II promotes vagal-mediated bradycardia by activating cardiac-projecting parasympathetic neurons of nucleus ambiguus.

J Neurochem 2014 May 6;129(4):628-36. Epub 2014 Mar 6.

Department of Pharmaceutical Sciences, Thomas Jefferson University, Jefferson School of Pharmacy, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1111/jnc.12679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000260PMC
May 2014

G protein-coupled receptor kinase 2: a link between myocardial contractile function and cardiac metabolism.

Circ Res 2014 May;114(10):1661-70

From the Department of Pharmacology, Center for Translational Medicine, Temple University, Philadelphia, PA (M.C.W., B.P.W., W.J.K.); and Department of Medicine and Surgery, University of Salerno, Salerno, Italy (M.C.).

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http://dx.doi.org/10.1161/CIRCRESAHA.114.300513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4095756PMC
May 2014

Dynamic mass redistribution analysis of endogenous β-adrenergic receptor signaling in neonatal rat cardiac fibroblasts.

Pharmacol Res Perspect 2014 Feb;2(1)

Center for Translational Medicine (R.L.C., L.A.G., J.E.Y., A.A.R., M.W., J.I., W.J.K. and D.G.T.) and Department of Pharmacology (W.J.K. and D.G.T.), Temple University School of Medicine, and Moulder Center for Drug Discovery Research and Temple University School of Pharmacy (M.A.J.), Philadelphia, PA 19140, USA.

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http://doi.wiley.com/10.1002/prp2.24
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http://dx.doi.org/10.1002/prp2.24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968527PMC
February 2014