Walter H A Kahr

Walter H A Kahr

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Walter H A Kahr

Walter H A Kahr

Publications by authors named "Walter H A Kahr"

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Abnormal fibrinolysis recognized by thromboelastography in a case of severe bleeding with normal coagulation and platelet function, leads to detection of a novel SERPINF2 variant causing severe alpha-2-antiplasmin deficiency.

Br J Haematol 2019 Sep 8;186(6):e198-e201. Epub 2019 Jul 8.

Division of Haematology/Oncology, Department of Paediatrics, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1111/bjh.16077DOI Listing
September 2019

Recent advances in inherited platelet disorders.

Curr Opin Hematol 2019 Sep;26(5):313-319

Cell Biology Program, Research Institute.

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http://dx.doi.org/10.1097/MOH.0000000000000525DOI Listing
September 2019

A Hypoxia-Inducible HIF1-GAL3ST1-Sulfatide Axis Enhances ccRCC Immune Evasion via Increased Tumor Cell-Platelet Binding.

Mol Cancer Res 2019 Aug 19. Epub 2019 Aug 19.

Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/1541-7786.MCR-19-0461DOI Listing
August 2019

Imaging Platelets and Megakaryocytes by High-Resolution Laser Fluorescence Microscopy.

Methods Mol Biol 2018 ;1812:13-31

Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1007/978-1-4939-8585-2_2DOI Listing
March 2019

NBEAL2 (Neurobeachin-Like 2) Is Required for Retention of Cargo Proteins by α-Granules During Their Production by Megakaryocytes.

Arterioscler Thromb Vasc Biol 2018 10;38(10):2435-2447

From the Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, ON, Canada (R.W.L., L.L., R.L., F.G.P., W.H.A.K.).

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.118.311270
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http://dx.doi.org/10.1161/ATVBAHA.118.311270DOI Listing
October 2018

NBEAL2 mutations and bleeding in patients with gray platelet syndrome.

Platelets 2018 Sep 5;29(6):632-635. Epub 2018 Jun 5.

a Cell Biology Program , Research Institute, Hospital for Sick Children , Toronto , ON , Canada.

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http://dx.doi.org/10.1080/09537104.2018.1478405DOI Listing
September 2018

Glanzmann thrombasthenia platelets compete with transfused platelets, reducing the haemostatic impact of platelet transfusions.

Br J Haematol 2018 05 3;181(3):410-413. Epub 2017 May 3.

Division of Haematology/Oncology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1111/bjh.14623DOI Listing
May 2018

Relative antibacterial functions of complement and NETs: NETs trap and complement effectively kills bacteria.

Mol Immunol 2018 05 20;97:71-81. Epub 2018 Mar 20.

Cell Biology Program, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada; Department of Paediatrics, University of Toronto, Toronto, ON, Canada; Division of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.molimm.2018.02.019DOI Listing
May 2018

The Birth and Death of Platelets in Health and Disease.

Physiology (Bethesda) 2018 05;33(3):225-234

Cell Biology Program, Research Institute, Hospital for Sick Children , Toronto, Ontario , Canada.

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http://dx.doi.org/10.1152/physiol.00005.2018DOI Listing
May 2018

Balancing the yin and yang of SINE.

Blood 2017 08;130(9):1077-1078

UNIVERSITY OF TORONTO.

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http://dx.doi.org/10.1182/blood-2017-07-793398DOI Listing
August 2017

Molecular structural analysis of a novel and de-novo mutation in the SERPINC1 gene associated with type 1 antithrombin deficiency.

Br J Haematol 2017 05 21;177(4):654-656. Epub 2016 Apr 21.

Department of Pediatrics, Division of Hematology/Oncology, Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA.

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http://dx.doi.org/10.1111/bjh.14090DOI Listing
May 2017

α-granule biogenesis: from disease to discovery.

Platelets 2017 Mar 22;28(2):147-154. Epub 2017 Feb 22.

a Department of Biochemistry , University of Toronto , Toronto , ON , Canada.

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http://dx.doi.org/10.1080/09537104.2017.1280599DOI Listing
March 2017

Complement Activation Induces Neutrophil Adhesion and Neutrophil-Platelet Aggregate Formation on Vascular Endothelial Cells.

Kidney Int Rep 2017 Jan 31;2(1):66-75. Epub 2016 Aug 31.

Cell Biology Program, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.ekir.2016.08.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678626PMC
January 2017

The Association Between Cyanosis and Thromboelastometry (ROTEM) in Children With Congenital Heart Defects: A Retrospective Cohort Study.

Anesth Analg 2017 01;124(1):23-29

From the *Department of Anesthesia, University of Toronto, Toronto, Ontario, Canada; †Division of Cardiac Anesthesia, The Hospital for Sick Children, Toronto, Ontario, Canada; ‡Department of Paediatrics and Biochemistry, University of Toronto, Toronto, Ontario, Canada; and §Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1213/ANE.0000000000001708DOI Listing
January 2017

Von Willebrand factor regulates complement on endothelial cells.

Kidney Int 2016 07 25;90(1):123-34. Epub 2016 May 25.

Division of Nephrology, The Hospital for Sick Children, Toronto, Ontario, Canada; Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada; Cell Biology Program, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2016.03.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591736PMC
July 2016

Impact of aerobic exercise on haemostatic indices in paediatric patients with haemophilia.

Thromb Haemost 2016 06 25;115(6):1120-8. Epub 2016 Feb 25.

Manuel Carcao, MD, MSc, Division of Haematology-Oncology, The Hospital for Sick Children, 555 University Avenue, Toronto, ON - M5G 1X8, Canada, Tel.: +1 416 813 5367, Fax: +1 416 813 5327, E-mail:

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http://dx.doi.org/10.1160/TH15-09-0757DOI Listing
June 2016

Intracellular Trafficking, Localization, and Mobilization of Platelet-Borne Thiol Isomerases.

Arterioscler Thromb Vasc Biol 2016 06 14;36(6):1164-73. Epub 2016 Apr 14.

From the School of Biological Sciences, University of Reading, Reading, United Kingdom (M.C., M.P.S., L.M.H., S.L., M.S.A., S.V., I.M.J., J.M.G.); Program in Cell Biology, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada (F.G.P., L.L., R.W.L., W.H.A.K.); Departments of Paediatrics and Biochemistry, University of Toronto, Toronto, Ontario, Canada (R.W.L., W.H.A.K.); School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom (T.G.W., A.W.P.); and Division of Hematology, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, Boston, MA (H.F.).

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http://dx.doi.org/10.1161/ATVBAHA.116.307461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407363PMC
June 2016

NETosing Neutrophils Activate Complement Both on Their Own NETs and Bacteria via Alternative and Non-alternative Pathways.

Front Immunol 2016 14;7:137. Epub 2016 Apr 14.

Cell Biology Program, The Hospital for Sick Children Research Institute, Toronto, ON, Canada; Program in Physiology and Experimental Medicine, The Hospital for Sick Children Research Institute, Toronto, ON, Canada; Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada; Department of Paediatrics, University of Toronto, Toronto, ON, Canada; Division of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada.

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http://dx.doi.org/10.3389/fimmu.2016.00137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831636PMC
May 2016

Platelet production: new players in the field.

Blood 2016 Feb;127(7):797-9

UNIVERSITY OF TORONTO.

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http://dx.doi.org/10.1182/blood-2016-01-687707DOI Listing
February 2016

c.1058C>T variant in the SERPINC1 gene is pathogenic for antithrombin deficiency.

Br J Haematol 2015 Jul 19;170(1):123-5. Epub 2014 Dec 19.

Department of Paediatrics, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1111/bjh.13261DOI Listing
July 2015

Postthrombotic syndrome following upper extremity deep vein thrombosis in children.

Blood 2014 Aug 23;124(7):1166-73. Epub 2014 Jun 23.

Division of Hematology/Oncology, Department of Pediatrics, and.

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http://dx.doi.org/10.1182/blood-2014-04-570531DOI Listing
August 2014

Clinical presentation and molecular basis of congenital antithrombin deficiency in children: a cohort study.

Br J Haematol 2014 Jul 29;166(1):130-9. Epub 2014 Mar 29.

Department of Pediatrics, Division of Hematology/Oncology, Nationwide Children's Hospital, The Ohio State University, OH, USA.

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http://dx.doi.org/10.1111/bjh.12842DOI Listing
July 2014

Congenital thrombocytopenia: clinical manifestations, laboratory abnormalities, and molecular defects of a heterogeneous group of conditions.

Hematol Oncol Clin North Am 2013 Jun;27(3):465-94

Division of Haematology/Oncology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.hoc.2013.02.004DOI Listing
June 2013

Coagulation assessment in children with diabetic ketoacidosis.

Pediatr Crit Care Med 2013 Mar;14(3):256-60

Critical Care Unit, Department of Paediatrics, Children's Hospital, University of Western Ontario, London, Ontario, Canada.

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http://dx.doi.org/10.1097/PCC.0b013e318271fcb7DOI Listing
March 2013

Interstitial deletion of 11q-implicating the KIRREL3 gene in the neurocognitive delay associated with Jacobsen syndrome.

Am J Med Genet A 2012 Oct 10;158A(10):2551-6. Epub 2012 Sep 10.

Division of Clinical and Metabolic Genetics, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/ajmg.a.35621DOI Listing
October 2012

The cell motility modulator Slit2 is a potent inhibitor of platelet function.

Circulation 2012 Sep 3;126(11):1385-95. Epub 2012 Aug 3.

The Hospital for Sick Children, 555 University Ave, Toronto, ON, Canada M5G 1X8.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.112.105452DOI Listing
September 2012

Gray platelet syndrome: macrothrombocytopenia with deficient α-granules.

Blood 2012 Sep;120(13):2543

Hospital for Sick Children and University of Toronto.

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http://dx.doi.org/10.1182/blood-2012-03-415778DOI Listing
September 2012

Extracellular matrix and platelet function in patients with musculocontractural Ehlers-Danlos syndrome caused by mutations in the CHST14 gene.

Am J Med Genet A 2012 Jun 11;158A(6):1344-54. Epub 2012 May 11.

Division of Clinical and Metabolic Genetics, Department of Paediatrics, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/ajmg.a.35339DOI Listing
June 2012

The role of prothrombotic factors in the ocular manifestations of abusive and non-abusive head trauma: a feasibility study.

Child Abuse Negl 2012 Apr 8;36(4):333-41. Epub 2012 May 8.

Institute of Medical Science, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1016/j.chiabu.2011.11.009DOI Listing
April 2012

Inherited platelet disorders: a clinical approach to diagnosis and management.

Expert Rev Hematol 2011 Aug;4(4):455-72

Department of Pediatrics, IWK Health Centre, Dalhousie University, Halifax, Canada.

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http://dx.doi.org/10.1586/ehm.11.41DOI Listing
August 2011

Platelet disorders in children: A diagnostic approach.

Pediatr Blood Cancer 2011 Jun 3;56(6):975-83. Epub 2011 Feb 3.

Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada.

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http://doi.wiley.com/10.1002/pbc.22988
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http://dx.doi.org/10.1002/pbc.22988DOI Listing
June 2011

The full-of-bacteria gene is required for phagosome maturation during immune defense in Drosophila.

J Cell Biol 2011 Feb 31;192(3):383-90. Epub 2011 Jan 31.

Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1083/jcb.201008119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101095PMC
February 2011

Complement halts angiogenesis gone wild.

Authors:
Walter H A Kahr

Blood 2010 Nov;116(22):4393-4

University OF Toronto, Canada.

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http://dx.doi.org/10.1182/blood-2010-08-297648DOI Listing
November 2010

Mutations in TTC37 cause trichohepatoenteric syndrome (phenotypic diarrhea of infancy).

Gastroenterology 2010 Jun 20;138(7):2388-98, 2398.e1-2. Epub 2010 Feb 20.

Department of Medical and Molecular Genetics, School of Clinical and Experimental Medicine, University of Birmingham College of Medical and Dental School, Institute of Biomedical Research, Edgbaston, Birmingham, UK.

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http://dx.doi.org/10.1053/j.gastro.2010.02.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166659PMC
June 2010

Megakaryocyte and platelet abnormalities in a patient with a W33C mutation in the conserved SH3-like domain of myosin heavy chain IIA.

Thromb Haemost 2009 Dec;102(6):1241-50

Department of Paediatrics, Division of Haematology/Oncology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1160/TH09-02-0119DOI Listing
December 2009

Idiopathic suppurative pylephlebitis: interventional radiological diagnosis and management.

Cardiovasc Intervent Radiol 2009 Nov 16;32(6):1304-7. Epub 2009 May 16.

Division of Image Guided Therapy, Department of Diagnostic Imaging, The Hospital for Sick Children, The University of Toronto, 555 University Avenue, Toronto, ON, M5G 1X8, Canada.

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http://dx.doi.org/10.1007/s00270-009-9586-7DOI Listing
November 2009

Platelet-associated complement factor H in healthy persons and patients with atypical HUS.

Blood 2009 Nov 24;114(20):4538-45. Epub 2009 Aug 24.

Department of Paediatrics, Division of Nephrology, Program in Cell Biology, The Hospital for Sick Children, and University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1182/blood-2009-03-205096DOI Listing
November 2009

The use of elastic compression stockings for post-thrombotic syndrome in a child.

Pediatr Blood Cancer 2009 Sep;53(3):462-3

Department of Haematology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada.

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http://dx.doi.org/10.1002/pbc.22077DOI Listing
September 2009

Fibrinogen is required for maintenance of platelet intracellular and cell-surface P-selectin expression.

Blood 2009 Jul 30;114(2):425-36. Epub 2009 Mar 30.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1182/blood-2008-03-145821DOI Listing
July 2009

Granules and thrombus formation.

Authors:
Walter H A Kahr

Blood 2009 Jul;114(5):932-3

University of Toronto.

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http://dx.doi.org/10.1182/blood-2009-05-220665DOI Listing
July 2009

Exercise-induced deep vein thrombosis of the upper extremity. 1. Literature review.

Acta Haematol 2006 ;115(3-4):214-20

Division of Haematology/Oncology, Department of Paediatrics, The Hospital for Sick Children, Toronto, Ont., Canada.

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http://dx.doi.org/10.1159/000090938DOI Listing
April 2006

Exercise-induced deep vein thrombosis of the upper extremity. 2. A case series in children.

Acta Haematol 2006 ;115(3-4):221-9

Division of Haematology/Oncology, Department of Paediatrics, The Hospital for Sick Children, Toronto, Ont., Canada.

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https://www.karger.com/Article/FullText/90939
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http://dx.doi.org/10.1159/000090939DOI Listing
April 2006

Requirement of VPS33B, a member of the Sec1/Munc18 protein family, in megakaryocyte and platelet alpha-granule biogenesis.

Blood 2005 Dec 25;106(13):4159-66. Epub 2005 Aug 25.

Department of Paediatrics, Division of Clinical and Metabolic Genetics, Programme in Cell Biology, The Hospital for Sick Children, University of Toronto, 555 University Ave, Toronto, ON, M5G 1X8, Canada.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2005-04-13
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http://dx.doi.org/10.1182/blood-2005-04-1356DOI Listing
December 2005

Liver biopsy complicated by hemorrhage in a patient with ARC syndrome.

Paediatr Anaesth 2004 Nov;14(11):960-3

Department of Anesthesia, Hospital for Sick Children, University Avenue, Toronto, Ontario, Canada.

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http://doi.wiley.com/10.1111/j.1460-9592.2004.01301.x
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http://dx.doi.org/10.1111/j.1460-9592.2004.01301.xDOI Listing
November 2004

Intracellular activation of the fibrinolytic cascade in the Quebec Platelet Disorder.

Thromb Haemost 2003 Aug;90(2):293-8

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1160/TH02-12-0323DOI Listing
August 2003