Walter Fiedler

Walter Fiedler

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Walter Fiedler

Walter Fiedler

Publications by authors named "Walter Fiedler"

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Interaction of PVR/PVRL2 with TIGIT/DNAM-1 as a novel immune checkpoint axis and therapeutic target in cancer.

Mamm Genome 2018 12 21;29(11-12):694-702. Epub 2018 Aug 21.

Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald University Cancer Center, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.

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http://dx.doi.org/10.1007/s00335-018-9770-7DOI Listing
December 2018

Acute Myeloid Leukemia and the Bone Marrow Niche-Take a Closer Look.

Front Oncol 2018 12;8:444. Epub 2018 Oct 12.

Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald University Cancer Center, University Medical Center Hamburg Eppendorf, Hamburg, Germany.

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https://www.frontiersin.org/article/10.3389/fonc.2018.00444/
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http://dx.doi.org/10.3389/fonc.2018.00444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195156PMC
October 2018

Acute hepatitis as a prequel to very severe aplastic anemia.

Z Gastroenterol 2018 01 9;56(1):51-54. Epub 2018 Jan 9.

Department of Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1055/s-0043-121737DOI Listing
January 2018

Combined inhibition of GLI and FLT3 signaling leads to effective anti-leukemic effects in human acute myeloid leukemia.

Oncotarget 2017 Apr;8(17):29187-29201

Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald University Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.18632/oncotarget.16304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438723PMC
April 2017

Improved Outcomes With Retinoic Acid and Arsenic Trioxide Compared With Retinoic Acid and Chemotherapy in Non-High-Risk Acute Promyelocytic Leukemia: Final Results of the Randomized Italian-German APL0406 Trial.

J Clin Oncol 2017 Feb 31;35(6):605-612. Epub 2016 Oct 31.

Uwe Platzbecker, Christian Thiede, Christoph Röllig, and Gerhard Ehninger, Universitätsklinikum Carl Gustav Carus der Technischen Universität Dresden; Uwe Platzbecker and Gerhard Ehninger, Study Alliance Leukemia, Dresden; Walter Fiedler, University Hospital Hamburg-Eppendorf; Norbert Schmitz, Asklepios Klinik St Georg Hamburg, Hamburg; Peter Brossart, Innere Medizin mit deSchwerpunkten Onkologie, Haematollogie un Rheumatologie, Bonn; Bernd Hertenstein, Klinikum Bremen Mitte, Bremen; Helmut R. Salih, University Hospital Tubingen; Mohammed Wattad, Kliniken Essen Süd, Essen; Michael Lübbert, University Medical Center, Freiburg; Christian H. Brandts, Goethe University Frankfurt, Frankfurt; Mathias Hänel, Klinikum Chemnitz gGmbH, Chemnitz; Hartmut Link, Klinik für Innere Medizin I, Westpfalz-Klinikum, Kaiserslautern; Konstanze Döhner, Hartmut Döhner, and Richard F. Schlenk, University Hospital Ulm, Ulm; Arnold Ganser, Hannover Medical School, Hannover, Germany; Giuseppe Avvisati, University Campus Bio-Medico; Laura Cicconi, Mariadomenica Divona, Sergio Amadori, and Francesco Lo-Coco, University Tor Vergata; Francesca Paoloni, Marco Vignetti, Fabio Efficace, Paola Fazi, and Franco Mandelli, Gruppo Italiano Malattie Ematologiche dell'Adulto Central Office; Marco Vignetti and Massimo Breccia, Sapienza University, Rome; Felicetto Ferrara, Cardarelli Hospital, Naples; Francesco Albano, University of Bari, Bari; Marco Sborgia, U.O. di Ematologia Clinica, Pescara; Eros Di Bona, San Bortolo Hospital, Vicenza; Erika Borlenghi, U.O. di Ematologia, Spedali Civili, Brescia; Roberto Cairoli, Ospedale Niguarda, Ca' Granda, SC Ematologia; Agostino Cortelezzi, Foundation Istituto di Ricovero e Cura a Carattere Scientifico Ca' Granda Ospedale Maggiore Policlinico and University of Milan, Milano; Alessandro Rambaldi, Azienda Opsedaliera Papa Giovanni XXIII, Bergamo; Lorella Melillo, Casa Sollievo della Sofferenza Hospital, IRCCS, San Giovanni Rotondo; Giorgio La Nasa, Centro Trapianti Midollo Osseo, Ospedale R. Binaghi, Università di Cagliari, Cagliari; Chiara Frairia, Hematology, Città della Salute e della Scienza, Torino; Enrico Maria Pogliani, Ospedale San Gerardo, Università degli Studi Milano Bicocca, Monza; Claudio Fozza, University of Sassari, Sassari; Alfonso Maria D'Arco, U.O. Medicina Interna e Onco-Ematologica P.O. "Umberto I," Nocera Inferiore, Nocera Inferiore; Nicola Di Renzo, Ospedale Vito Fazzi, Lecce; and Francesco Fabbiano, Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy.

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http://dx.doi.org/10.1200/JCO.2016.67.1982DOI Listing
February 2017

Deoxycytidine kinase is downregulated under hypoxic conditions and confers resistance against cytarabine in acute myeloid leukaemia.

Eur J Haematol 2016 Sep 28;97(3):239-44. Epub 2015 Dec 28.

Department of Oncology, Haematology and Bone Marrow Transplantation with section Pneumology, Hubertus Wald University Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1111/ejh.12711DOI Listing
September 2016

Hodgkin's lymphoma as a rare variant of Richter's transformation in chronic lymphocytic leukemia: A case report and review of the literature.

Mol Clin Oncol 2016 Mar 8;4(3):390-392. Epub 2016 Jan 8.

Department of Oncology and Hematology, BMT with Section of Pneumology, Hubertus Wald Tumorzentrum, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

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http://dx.doi.org/10.3892/mco.2016.727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4774418PMC
March 2016

Intrinsic BMP Antagonist Gremlin-1 as a Novel Circulating Marker in Pulmonary Arterial Hypertension.

Lung 2015 Aug 30;193(4):567-70. Epub 2015 Apr 30.

Department of Hematology, Oncology and Stem Cell Transplantation with Section Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany,

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http://dx.doi.org/10.1007/s00408-015-9735-5DOI Listing
August 2015

ErbB2 signaling activates the Hedgehog pathway via PI3K-Akt in human esophageal adenocarcinoma: identification of novel targets for concerted therapy concepts.

Cell Signal 2015 Feb 27;27(2):373-81. Epub 2014 Nov 27.

Hubertus Wald Tumorzentrum, Department of Oncology-Hematology, Bone Marrow Transplantation and Pneumology, University Cancer Center, Hamburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2014.11.022DOI Listing
February 2015

Thrombin generation in a patient with an acquired high-titre factor V inhibitor.

Blood Coagul Fibrinolysis 2015 Jan;26(1):81-7

aUtrecht University Medical Center, Utrecht, The Netherlands bII. Medizinische Klinik und Poliklinik cInstitut für Klinische Chemie, Universitätsklinikum Eppendorf, Hamburg, Germany dDepartment for Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden *David E. Schmidt and Friederike Steinhagen contributed equally to this work.

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http://dx.doi.org/10.1097/MBC.0000000000000181DOI Listing
January 2015

Volasertib for the treatment of acute myeloid leukemia: a review of preclinical and clinical development.

Future Oncol 2014 May;10(7):1157-65

Department of Hematology, Oncology & Bone Marrow Transplantation with Section Pneumology, Hubertus Wald University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Martinistrasse 52 D-20246, Hamburg, Germany.

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http://dx.doi.org/10.2217/fon.14.53DOI Listing
May 2014

New antiangiogenic strategies beyond inhibition of vascular endothelial growth factor with special focus on axon guidance molecules.

Oncology 2014 3;86(1):46-52. Epub 2014 Jan 3.

Department of Internal Medicine V, Hematology and Oncology, Medical University Innsbruck, Innsbruck, Austria.

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http://dx.doi.org/10.1159/000356871DOI Listing
March 2014

Late recurrence of a pineal germinoma 14 years after radiation and chemotherapy: a case report and review of the literature.

Onkologie 2013 21;36(6):371-3. Epub 2013 May 21.

Department of Oncology and Hematology, Hubertus Wald Tumor Center - University Cancer Center Hamburg, Germany.

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http://dx.doi.org/10.1159/000351255DOI Listing
January 2014

Combination therapy targeting integrins reduces glioblastoma tumor growth through antiangiogenic and direct antitumor activity and leads to activation of the pro-proliferative prolactin pathway.

Mol Cancer 2013 Nov 20;12(1):144. Epub 2013 Nov 20.

Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, University Cancer Center Hamburg (UCCH), Universtity Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://molecular-cancer.biomedcentral.com/articles/10.1186/1
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http://dx.doi.org/10.1186/1476-4598-12-144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176123PMC
November 2013

Axl, a prognostic and therapeutic target in acute myeloid leukemia mediates paracrine crosstalk of leukemia cells with bone marrow stroma.

Blood 2013 Oct 27;122(14):2443-52. Epub 2013 Aug 27.

Department of Hematology, Oncology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Tumorzentrum, University Comprehensive Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;

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http://dx.doi.org/10.1182/blood-2013-03-491431DOI Listing
October 2013

Acute megakaryoblastic leukemia in a patient with xeroderma pigmentosum: discussion of pathophysiological, prognostic, and toxicological aspects.

Acta Haematol 2013 28;129(2):121-5. Epub 2012 Nov 28.

Department of Oncology and Hematology, BMT with Section of Pneumology, Hubertus Wald Tumorzentrum, University Cancer Center Hamburg, Hamburg, Germany.

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http://dx.doi.org/10.1159/000342897DOI Listing
April 2013

Prognostic significance of expression levels of stem cell regulators MSI2 and NUMB in acute myeloid leukemia.

Ann Hematol 2013 Mar 12;92(3):315-23. Epub 2012 Dec 12.

Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Carl-Neuberg Str. 1, 30625, Hannover, Germany.

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http://dx.doi.org/10.1007/s00277-012-1637-5DOI Listing
March 2013

VEGFR-1 expression levels predict occurrence of disseminated tumor cells in the bone marrow of patients with esophageal carcinoma.

Clin Exp Metastasis 2012 Dec 8;29(8):879-87. Epub 2012 Apr 8.

Department of Hematology and Oncology with Sections BMT and Pneumology, Hubertus Wald Tumorzentrum, University Comprehensive Cancer Center Hamburg, Hamburg, Germany.

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http://dx.doi.org/10.1007/s10585-012-9477-1DOI Listing
December 2012

The metabolite 3-hydroxiglutaric acid effectively reduces glioblastoma growth in vivo by affecting the structural integrity of tumor vasculature.

Cancer Lett 2012 Dec 16;326(2):161-7. Epub 2012 Aug 16.

Department of Oncology and Hematology with Section Pneumology, Oncology Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S03043835120044
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http://dx.doi.org/10.1016/j.canlet.2012.08.002DOI Listing
December 2012

Critical imbalance of TNF-α and soluble TNF receptor 1 in a patient with macrophage activation syndrome: potential implications for diagnostics and treatment.

Acta Haematol 2012 6;128(2):69-72. Epub 2012 Jun 6.

Departments of Oncology and Hematology, University Medical Center Hamburg-Eppendorf, Hubertus Wald Cancer Center, Hamburg, Germany.

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http://dx.doi.org/10.1159/000338179DOI Listing
October 2012

CD146: a new partner for VEGFR2.

Blood 2012 Sep;120(11):2164-5

Hubertus Wald University Cancer Center, University Medical Center Hamburg-Eppendorf.

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http://dx.doi.org/10.1182/blood-2012-07-439646DOI Listing
September 2012

Clinical importance and potential use of small molecule inhibitors of focal adhesion kinase.

Anticancer Agents Med Chem 2011 Sep;11(7):593-9

University Medical Center Hamburg - Eppendorf, Hubertus Wald University Cancer Center Hamburg, Department of Oncology/Hematology with Sections BMT and Pneumology, Hamburg, Germany.

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September 2011

Primary tumor dependent inhibition of tumor growth, angiogenesis, and perfusion of secondary breast cancer in bone.

J Orthop Res 2011 Aug 4;29(8):1251-8. Epub 2011 Mar 4.

Orthopaedic Spine Surgery, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany.

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http://dx.doi.org/10.1002/jor.21402DOI Listing
August 2011

Tgf-Beta superfamily receptors-targets for antiangiogenic therapy?

J Oncol 2010 13;2010:317068. Epub 2010 May 13.

Sections of Pneumonology and Bone Marrow Transplantation, Department of Oncology and Hematology, Hubertus Wald University Cancer Center, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

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http://dx.doi.org/10.1155/2010/317068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871186PMC
July 2011

A phase I study of recombinant human interleukin-21 (rIL-21) in combination with sunitinib in patients with metastatic renal cell carcinoma (RCC).

Acta Oncol 2011 Jan;50(1):121-6

Medical School Hannover, Clinic for Hematology, Hemostaseology, Oncology and Stem Cell Transplantation, Germany.

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http://dx.doi.org/10.3109/0284186X.2010.509104DOI Listing
January 2011

TAE226-mediated inhibition of focal adhesion kinase interferes with tumor angiogenesis and vasculogenesis.

Invest New Drugs 2010 Dec 26;28(6):825-33. Epub 2009 Sep 26.

University Medical Center Hamburg-Eppendorf, Hubertus Wald University Cancer Center Hamburg, Dept. of Oncology/Hematology with sections BMT and Pneumology, Hamburg, Germany.

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http://link.springer.com/content/pdf/10.1007/s10637-009-9326
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http://link.springer.com/10.1007/s10637-009-9326-5
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http://dx.doi.org/10.1007/s10637-009-9326-5DOI Listing
December 2010

Heterogenous high-level HER-2 amplification in a small subset of colorectal cancers.

Hum Pathol 2010 Nov 24;41(11):1577-85. Epub 2010 Jul 24.

Institute for Pathology, Hubertus Wald Tumorzentrum-University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany.

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http://dx.doi.org/10.1016/j.humpath.2010.02.018DOI Listing
November 2010

Microcirculation of secondary bone tumors in vivo: the impact of minor surgery at a distal site.

J Orthop Res 2010 Nov;28(11):1515-21

Orthopaedic Spine Surgery, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.

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http://dx.doi.org/10.1002/jor.21166DOI Listing
November 2010

Prognostic impact of IDH2 mutations in cytogenetically normal acute myeloid leukemia.

Blood 2010 Jul 26;116(4):614-6. Epub 2010 Apr 26.

Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Carl-Neuberg Strasse 1, Hannover, Germany.

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http://dx.doi.org/10.1182/blood-2010-03-272146DOI Listing
July 2010

Therapeutic potential and limitations of new FAK inhibitors in the treatment of cancer.

Expert Opin Investig Drugs 2010 Jun;19(6):777-88

University Medical Center Hamburg-Eppendorf, Hubertus Wald Tumorzentrum-University Cancer Center Hamburg, Department of Oncology/Hematology, Hamburg, Germany.

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http://dx.doi.org/10.1517/13543784.2010.489548DOI Listing
June 2010

FLT3 - ITD positive acute lymphocytic leukemia, does it impact on disease´s course?

Turk J Haematol 2010 Jun;27(2):133-4

Petersgraben 4 4057 Basel, Switzerland, Phone: +41-61 3286099 Office: +41 612652525 E-mail:

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http://dx.doi.org/10.5152/tjh.2010.18DOI Listing
June 2010

Isolated limb perfusion with melphalan for the treatment of intractable primary cutaneous diffuse large B-cell lymphoma leg type.

Acta Haematol 2010 11;123(3):179-81. Epub 2010 Mar 11.

Department of Oncology, Hematology and Bone Marrow Transplantation, University Medical Center Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1159/000294963DOI Listing
April 2010

An open-label, Phase I study of cediranib (RECENTIN) in patients with acute myeloid leukemia.

Leuk Res 2010 Feb 11;34(2):196-202. Epub 2009 Aug 11.

Department of Oncology, Hematology, BMT with section Pneumology Hubertus Wald Tumorzentrum - University Cancer Center Hamburg University Medical Center Hamburg Eppendorf 20246 Hamburg, Germany.

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http://dx.doi.org/10.1016/j.leukres.2009.07.020DOI Listing
February 2010

Primary NK/T cell lymphoma nasal type of the stomach with skin involvement: a case report.

Rare Tumors 2009 Dec 28;1(2):e58. Epub 2009 Dec 28.

Department of Oncology/Hematology/ Bone Marrow Transplantation/ Pneumology, University Medical Center Eppendorf;

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http://dx.doi.org/10.4081/rt.2009.e58DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994465PMC
December 2009

Cilengitide induces cellular detachment and apoptosis in endothelial and glioma cells mediated by inhibition of FAK/src/AKT pathway.

J Exp Clin Cancer Res 2008 Dec 29;27:86. Epub 2008 Dec 29.

Department of Oncology and Hematology with Section Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1186/1756-9966-27-86DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648308PMC
December 2008

Blood outgrowth endothelial cells from chronic myeloid leukaemia patients are BCR/ABL1 negative.

Br J Haematol 2008 Jul 8;142(1):115-8. Epub 2008 May 8.

Department of Internal Medicine II, Cancer Centre, University Hospital Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1111/j.1365-2141.2008.07195.xDOI Listing
July 2008

Managing side effects of angiogenesis inhibitors in renal cell carcinoma.

Onkologie 2007 Oct 21;30(10):519-24. Epub 2007 Sep 21.

Department of Hematology, Hemostaseology and Oncology, Hannover Medical School, Germany.

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http://dx.doi.org/10.1159/000107721DOI Listing
October 2007

Cilengitide inhibits proliferation and differentiation of human endothelial progenitor cells in vitro.

Biochem Biophys Res Commun 2007 Jun 19;357(4):1016-20. Epub 2007 Apr 19.

University Hospital Hamburg-Eppendorf, Department of Medicine, Hamburg, Germany.

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http://dx.doi.org/10.1016/j.bbrc.2007.04.060DOI Listing
June 2007

Quantitative multiplexed profiling of cellular signaling networks using phosphotyrosine-specific DNA-tagged SH2 domains.

Nat Methods 2006 Sep;3(9):737-44

Department of Clinical Chemistry, Center of Clinical Pathology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany.

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http://dx.doi.org/10.1038/nmeth917DOI Listing
September 2006

Detection of N-RAS and K-RAS in their active GTP-bound form in acute myeloid leukemia without activating RAS mutations.

Leuk Lymphoma 2006 Jul;47(7):1387-91

Center of Experimental Medicine, Institute of Biochemistry and Molecular Biology I, Cellular Signal Transduction, University Hospital Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1080/10428190600565925DOI Listing
July 2006

Extracellular KIT receptor mutants, commonly found in core binding factor AML, are constitutively active and respond to imatinib mesylate.

Blood 2005 Dec 4;106(12):3958-61. Epub 2005 Aug 4.

Molecular Pathology Group, Heinrich-Pette-Institut, PO Box 201 652, D-20206 Hamburg, Germany.

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http://dx.doi.org/10.1182/blood-2005-02-0583DOI Listing
December 2005

Long-term observation reveals time-course-dependent characteristics of tumour vascularisation.

Eur J Cancer 2005 May;41(7):1073-85

Department of Orthopedic Surgery, University Hospital Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.

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http://dx.doi.org/10.1016/j.ejca.2004.12.034DOI Listing
May 2005

Case 2. Hemangioblastomas: diagnosis of von Hippel-Lindau disease and antiangiogenic treatment with SU5416.

J Clin Oncol 2005 May;23(15):3624-6

Department of Medicine, University Hospital Hamburg-Eppendorf, University of Hamburg, Germany.

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http://dx.doi.org/10.1200/JCO.2005.01.184DOI Listing
May 2005

Rapamycin inhibits proliferation and differentiation of human endothelial progenitor cells in vitro.

Exp Cell Res 2004 Oct;300(1):65-71

Department of Medicine, University Hospital Hamburg-Eppendorf, 20246 Hamburg, Germany.

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http://dx.doi.org/10.1016/j.yexcr.2004.07.002DOI Listing
October 2004