Walter Berger

Walter Berger

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Walter Berger

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Subcellular Duplex DNA and G-Quadruplex Interaction Profiling of a Hexagonal Pt Metallacycle.

Angew Chem Int Ed Engl 2019 Jun 8;58(24):8007-8012. Epub 2019 May 8.

University of Vienna, Institute of Inorganic Chemistry, Waehringerstrasse 42, A-1090, Vienna, Austria.

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http://dx.doi.org/10.1002/anie.201900934DOI Listing
June 2019

Synthesis and biological evaluation of biotin-conjugated anticancer thiosemicarbazones and their iron(III) and copper(II) complexes.

J Inorg Biochem 2019 Jan 19;190:85-97. Epub 2018 Oct 19.

Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Waehringer Str. 42, A-1090 Vienna, Austria; Research Cluster "Translational Cancer Therapy Research", Vienna, Austria.

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https://linkinghub.elsevier.com/retrieve/pii/S01620134183035
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http://dx.doi.org/10.1016/j.jinorgbio.2018.10.006DOI Listing
January 2019

Metal Drugs and the Anticancer Immune Response.

Chem Rev 2019 Jan 29;119(2):1519-1624. Epub 2018 Nov 29.

Institute of Cancer Research and Comprehensive Cancer Center, Department of Medicine I , Medical University of Vienna , Borschkegasse 8a , A-1090 Vienna , Austria.

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http://pubs.acs.org/doi/10.1021/acs.chemrev.8b00396
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http://dx.doi.org/10.1021/acs.chemrev.8b00396DOI Listing
January 2019

Synthesis, Characterization and in vitro Studies of a Cathepsin B-Cleavable Prodrug of the VEGFR Inhibitor Sunitinib.

Chem Biodivers 2019 Jan 19;16(1):e1800520. Epub 2018 Dec 19.

Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Waehringer Straße 42, AT-1090, Wien.

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http://dx.doi.org/10.1002/cbdv.201800520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391952PMC
January 2019

Lysosomal Sequestration Impairs the Activity of the Preclinical FGFR Inhibitor PD173074.

Cells 2018 Dec 8;7(12). Epub 2018 Dec 8.

Institute of Cancer Research and Comprehensive Cancer Center, Department of Medicine I, Medical University of Vienna, A-1090 Vienna, Austria.

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http://www.mdpi.com/2073-4409/7/12/259
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http://dx.doi.org/10.3390/cells7120259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315953PMC
December 2018

Nanoformulations of anticancer FGFR inhibitors with improved therapeutic index.

Nanomedicine 2018 11 16;14(8):2632-2643. Epub 2018 Aug 16.

University of Vienna, Faculty of Chemistry, Institute of Inorganic Chemistry, Vienna, Austria; Research Cluster "Translational Cancer Therapy Research", Vienna, Austria.

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https://linkinghub.elsevier.com/retrieve/pii/S15499634183050
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http://dx.doi.org/10.1016/j.nano.2018.08.001DOI Listing
November 2018

Serum-binding properties of isosteric ruthenium and osmium anticancer agents elucidated by SEC-ICP-MS.

Monatsh Chem 2018 25;149(10):1719-1726. Epub 2018 Aug 25.

1Institute of Inorganic Chemistry, University of Vienna, Waehringer Strasse 42, 1090 Vienna, Austria.

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http://dx.doi.org/10.1007/s00706-018-2280-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133104PMC
August 2018

Bioimaging of isosteric osmium and ruthenium anticancer agents by LA-ICP-MS.

Metallomics 2018 03 7;10(3):388-396. Epub 2018 Mar 7.

Institute of Inorganic Chemistry, University of Vienna, Vienna, Austria and Research Cluster 'Translational Cancer Therapy Research', University and Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1039/c8mt00012cDOI Listing
March 2018

Human tripartite motif protein 52 is required for cell context-dependent proliferation.

Oncotarget 2018 Mar 5;9(17):13565-13581. Epub 2018 Feb 5.

Department of Microbiology, Immunobiology, and Genetics, Max F. Perutz Laboratories, University of Vienna, Vienna Biocenter, Vienna 1030, Austria.

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http://dx.doi.org/10.18632/oncotarget.24422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862599PMC
March 2018

Structure-activity relationships for ruthenium and osmium anticancer agents - towards clinical development.

Chem Soc Rev 2018 Feb;47(3):909-928

University of Vienna, Department of Analytical Chemistry, Waehringer Str. 38, A-1090 Vienna, Austria.

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http://dx.doi.org/10.1039/c7cs00332cDOI Listing
February 2018

Dynamics of CRISPR/Cas9-mediated genomic editing of the locus in hepatocellular carcinoma cells.

Oncol Lett 2018 Feb 13;15(2):2441-2450. Epub 2017 Dec 13.

Department of Medicine I, Institute of Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, A-1090 Vienna, Austria.

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http://dx.doi.org/10.3892/ol.2017.7605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777348PMC
February 2018

Telomerase activation in posterior fossa group A ependymomas is associated with dismal prognosis and chromosome 1q gain.

Neuro Oncol 2017 Sep;19(9):1183-1194

Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Austria; Comprehensive Cancer Center, Medical University of Vienna, Austria; Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Austria; Neuromed Campus, Kepler University Hospital, Linz, Austria; Institute of Neurology, Medical University of Vienna, Austria; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Pediatric Oncology, Hematology and Immunology, University Hospital Heidelberg, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Neuropathology, University Hospital Heidelberg, Germany; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Neurosurgery, Medical University of Vienna, Austria; Department of Radiotherapy, Medical University of Vienna, Austria.

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http://dx.doi.org/10.1093/neuonc/nox027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570194PMC
September 2017

[C]Erlotinib PET cannot detect acquired erlotinib resistance in NSCLC tumor xenografts in mice.

Nucl Med Biol 2017 Sep 25;52:7-15. Epub 2017 May 25.

Biomedical Systems, Center for Health & Bioresources, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria; Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria; Division of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09698051173011
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http://dx.doi.org/10.1016/j.nucmedbio.2017.05.007DOI Listing
September 2017

Sensitivity towards the GRP78 inhibitor KP1339/IT-139 is characterized by apoptosis induction via caspase 8 upon disruption of ER homeostasis.

Cancer Lett 2017 09 14;404:79-88. Epub 2017 Jul 14.

Department of Medicine I, Institute of Cancer Research, Comprehensive Cancer Center of the Medical University, Medical University of Vienna, Borschkegasse 8a, A-1090, Vienna, Austria; Research Cluster "Translational Cancer Therapy Research", Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2017.07.009DOI Listing
September 2017

Synthesis and in vivo anticancer evaluation of poly(organo)phosphazene-based metallodrug conjugates.

Dalton Trans 2017 Sep 1;46(36):12114-12124. Epub 2017 Sep 1.

Institute of Inorganic Chemistry, University of Vienna, Waehringer Str. 42, 1090 Wien, Austria. and Research Cluster "Translational Cancer Therapy Research", University of Vienna, Waehringer Str. 42, 1090 Wien, Austria.

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http://dx.doi.org/10.1039/c7dt01767gDOI Listing
September 2017

The Natural Fungal Metabolite Beauvericin Exerts Anticancer Activity In Vivo: A Pre-Clinical Pilot Study.

Toxins (Basel) 2017 08 24;9(9). Epub 2017 Aug 24.

Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, and Comprehensive Cancer Center of the Medical University, Borschkegasse 8a, 1090 Vienna, Austria.

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http://dx.doi.org/10.3390/toxins9090258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618191PMC
August 2017

Metal drugs become targeted.

ESMO Open 2017 17;2(3):e000239. Epub 2017 Aug 17.

Department of Medicine I, Institute of Cancer Research, Medical University Vienna, Vienna, Austria.

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http://dx.doi.org/10.1136/esmoopen-2017-000239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604710PMC
August 2017

Anion-Exchange Chromatography Coupled to High-Resolution Mass Spectrometry: A Powerful Tool for Merging Targeted and Non-targeted Metabolomics.

Anal Chem 2017 07 27;89(14):7667-7674. Epub 2017 Jun 27.

Department of Analytical Chemistry, Faculty of Chemistry, University of Vienna , Waehringer Strasse 38, 1090 Vienna, Austria.

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http://dx.doi.org/10.1021/acs.analchem.7b01624DOI Listing
July 2017

Irinotecan Upregulates Fibroblast Growth Factor Receptor 3 Expression in Colorectal Cancer Cells, Which Mitigates Irinotecan-Induced Apoptosis.

Transl Oncol 2017 Jun 22;10(3):332-339. Epub 2017 Mar 22.

Medical University of Vienna, Department of Medicine 1, Institute of Cancer Research and Comprehensive Cancer Center Vienna, Borschkegasse 8a, 1090 Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.tranon.2017.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367848PMC
June 2017

EGFR-targeting peptide-coupled platinum(IV) complexes.

J Biol Inorg Chem 2017 Jun 12;22(4):591-603. Epub 2017 Apr 12.

Institute of Inorganic Chemistry, University of Vienna, Waehringer Strasse 42, A-1090, Vienna, Austria.

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http://dx.doi.org/10.1007/s00775-017-1450-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443859PMC
June 2017

Post-digestion stabilization of osmium enables quantification by ICP-MS in cell culture and tissue.

Analyst 2017 Jun;142(13):2327-2332

Institute of Inorganic Chemistry, University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1039/c7an00350aDOI Listing
June 2017

Computed determination of the in vitro optimal chemocombinations of sphaeropsidin A with chemotherapeutic agents to combat melanomas.

Cancer Chemother Pharmacol 2017 May 7;79(5):971-983. Epub 2017 Apr 7.

Laboratoire de Cancérologie et Toxicologie Expérimentale, Université Libre de Bruxelles, Boulevard du Triomphe, Accès 2, 1050, Ixelles, Belgium.

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http://dx.doi.org/10.1007/s00280-017-3293-xDOI Listing
May 2017

Distinct activity of the bone-targeted gallium compound KP46 against osteosarcoma cells - synergism with autophagy inhibition.

J Exp Clin Cancer Res 2017 04 12;36(1):52. Epub 2017 Apr 12.

Department of Medicine I, Institute of Cancer Research and Comprehensive Cancer Center, Medical University Vienna, Borschkegasse 8a, A-1090, Vienna, Austria.

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http://dx.doi.org/10.1186/s13046-017-0527-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389188PMC
April 2017

Comparative studies of oxaliplatin-based platinum(iv) complexes in different in vitro and in vivo tumor models.

Metallomics 2017 03;9(3):309-322

University of Vienna, Institute of Inorganic Chemistry, Waehringer Strasse 42, 1090 Vienna, Austria. and University of Vienna, Research Platform "Translational Cancer Therapy Research", Vienna, Austria.

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http://dx.doi.org/10.1039/c6mt00226aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130776PMC
March 2017

An albumin-based tumor-targeted oxaliplatin prodrug with distinctly improved anticancer activity .

Chem Sci 2017 Mar 15;8(3):2241-2250. Epub 2016 Dec 15.

University of Vienna , Institute of Inorganic Chemistry , Waehringer Strasse 42 , A-1090 , Vienna , Austria . Email: ; ; Tel: +43-1-4277-52609.

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http://dx.doi.org/10.1039/c6sc03862jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409245PMC
March 2017

{Ru(CO)}-Core complexes with benzimidazole ligands: synthesis, X-ray structure and evaluation of anticancer activity in vivo.

Dalton Trans 2017 Feb;46(9):3025-3040

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.

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http://dx.doi.org/10.1039/c6dt04295cDOI Listing
February 2017

Anticancer metal drugs and immunogenic cell death.

J Inorg Biochem 2016 12 16;165:71-79. Epub 2016 Jun 16.

Research Platform "Translational Cancer Therapy Research", University of Vienna and Medical University of Vienna, Vienna, Austria; Department of Medicine I, Institute of Cancer Research and Comprehensive Cancer Center, Medical University Vienna, Borschkegasse 8a, A-1090 Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.jinorgbio.2016.06.021DOI Listing
December 2016

Loss of phosphodiesterase 4D mediates acquired triapine resistance via Epac-Rap1-Integrin signaling.

Oncotarget 2016 Dec;7(51):84556-84574

Department of Medicine I, Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, A-1090 Vienna, Austria.

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http://dx.doi.org/10.18632/oncotarget.11821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356681PMC
December 2016

Trabectedin Is Active against Malignant Pleural Mesothelioma Cell and Xenograft Models and Synergizes with Chemotherapy and Bcl-2 Inhibition In Vitro.

Mol Cancer Ther 2016 10 10;15(10):2357-2369. Epub 2016 Aug 10.

Applied and Experimental Oncology, Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-0846DOI Listing
October 2016

Macromolecular Pt(IV) Prodrugs from Poly(organo)phosphazenes.

Macromol Biosci 2016 08 12;16(8):1239-1249. Epub 2016 May 12.

Institute of Polymer Chemistry, Johannes Kepler University Linz, Altenberger Straße 69, 4040 Linz, Austria.

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http://dx.doi.org/10.1002/mabi.201600035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976076PMC
August 2016

Circulating activin A is a novel prognostic biomarker in malignant pleural mesothelioma - A multi-institutional study.

Eur J Cancer 2016 08 8;63:64-73. Epub 2016 Jun 8.

Division of Thoracic Surgery, Department of Surgery, Comprehensive Cancer Center Vienna, Medical University of Vienna, Vienna, Austria; Department of Biomedical Imaging and Image-guided Therapy, Division of Molecular and Gender Imaging, Medical University of Vienna, Vienna, Austria; MTA-SE Molecular Oncology Research Group, Hungarian Academy of Sciences, Budapest, Hungary. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2016.04.018DOI Listing
August 2016

Differences in protein binding and excretion of Triapine and its Fe(III) complex.

J Inorg Biochem 2016 07 19;160:61-9. Epub 2015 Oct 19.

Institute of Inorganic Chemistry, University of Vienna, Waehringer Strasse 42, 1090 Vienna, Austria; Research Platform "Translational Cancer Therapy Research", University of Vienna and Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1016/j.jinorgbio.2015.10.006DOI Listing
July 2016

Opposing Roles of JNK and p38 in Lymphangiogenesis in Melanoma.

J Invest Dermatol 2016 05 30;136(5):967-977. Epub 2016 Jan 30.

Department of Dermatology, Skin and Endothelium Research Division (SERD), Medical University of Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2016.01.020DOI Listing
May 2016

Mouse tissue distribution and persistence of the food-born fusariotoxins Enniatin B and Beauvericin.

Toxicol Lett 2016 Apr 15;247:35-44. Epub 2016 Feb 15.

Department of Pharmacology and Toxicology, University of Vienna, Althanstr. 14, A-1090 Vienna, Austria; Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Borschkegasse 8a, 1090 Vienna, Austria; Comprehensive Cancer Center of the Medical University, Spitalgasse 23, 1090 Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.toxlet.2016.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850989PMC
April 2016

32nd International Austrian Winter Symposium : Zell am See, the Netherlands. 20-23 January 2016.

Authors:
W Langsteger A Rezaee W Loidl H S Geinitz F Fitz M Steinmair G Broinger L Pallwien-Prettner M Beheshti L Imamovic M Beheshti G Rendl D Hackl O Tsybrovsky M Steinmair K Emmanuel F Moinfar C Pirich W Langsteger A Bytyqi G Karanikas M Mayerhöfer O Koperek B Niederle M Hartenbach T Beyer K Herrmann J Czernin I Rausch P Rust M D DiFranco M Lassen A Stadlbauer M E Mayerhöfer M Hartenbach M Hacker T Beyer K Binzel R Magnussen W Wei M U Knopp D C Flanigan C Kaeding M V Knopp A Leisser M Nejabat M Hartenbach G Kramer M Krainer M Hacker A Haug Wencke Lehnert Karl Schmidt Sharok Kimiaei Marcus Bronzel Andreas Kluge C L Wright K Binzel J Zhang Evan Wuthrick Piotr Maniawski M V Knopp M Blaickner E Rados A Huber M Dulovits H Kulkarni S Wiessalla C Schuchardt R P Baum B Knäusl D Georg M Bauer B Wulkersdorfer W Wadsak C Philippe H Haslacher M Zeitlinger O Langer M Bauer M Feldmann R Karch W Wadsak M Zeitlinger M J Koepp M-C Asselin E Pataraia O Langer M Zeilinger C Philippe M Dumanic F Pichler J Pilz M Hacker W Wadsak M Mitterhauser L Nics B Steiner M Hacker M Mitterhauser W Wadsak A Traxl Thomas Wanek Kushtrim Kryeziu Severin Mairinger Johann Stanek Walter Berger Claudia Kuntner Oliver Langer S Mairinger T Wanek A Traxl M Krohn J Stanek T Filip M Sauberer C Kuntner J Pahnke O Langer D Svatunek C Denk M Wilkovitsch T Wanek T Filip C Kuntner-Hannes J Fröhlich H Mikula C Denk D Svatunek T Wanek S Mairinger J Stanek T Filip J Fröhlich H Mikula C Kuntner-Hannes T Balber J Singer J Fazekas C Rami-Mark N Berroterán-Infante E Jensen-Jarolim W Wadsak M Hacker H Viernstein M Mitterhauser C Denk D Svatunek B Sohr H Mikula J Fröhlich T Wanek C Kuntner-Hannes T Filip S Pfaff C Philippe M Mitterhauser M Hartenbach M Hacker W Wadsak T Wanek E Halilbasic M Visentin S Mairinger B Stieger C Kuntner M Trauner O Langer P Lam M Aistleitner R Eichinger C Artner H Eidherr C Vraka A Haug M Mitterhauser L Nics M Hartenbach M Hacker W Wadsak H Kvaternik R Müller D Hausberger C Zink R M Aigner U Cossío M Asensio A Montes S Akhtar Y Te Welscher R van Nostrum V Gómez-Vallejo J Llop F VandeVyver T Barclay N Lippens M Troch L Hehenwarter B Egger J Holzmannhofer M Rodrigues-Radischat C Pirich N Pötsch I Rausch D Wilhelm M Weber J Furtner G Karanikas A Wöhrer M Mitterhauser M Hacker T Traub-Weidinger T Cassou-Mounat S Balogova V Nataf M Calzada V Huchet K Kerrou J-Y Devaux M Mohty L Garderet J-N Talbot S Stanzel G Pregartner T Schwarz V Bjelic-Radisic B Liegl-Atzwanger R Aigner S Stanzel F Quehenberger R M Aigner A Koljević Marković Milica Janković V Miler Jerković M Paskaš G Pupić R Džodić D Popović M C Fornito D Familiari P Koranda H Polzerová I Metelková L Henzlová R Formánek E Buriánková M Kamínek W H Thomson C Lewis W H Thomson J O'Brien G James A Notghi H Huber I Stelzmüller R Wunn M Mandl F Fellner B Lamprecht M Gabriel M C Fornito G Leonardi W H Thomson J O'Brien G James J Hudzietzová J Sabol M Fülöp

EJNMMI Res 2016 Apr 18;6(Suppl 1):32. Epub 2016 Apr 18.

Faculty of Public Health, SMU, Bratislava, Slovak Republic.

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http://dx.doi.org/10.1186/s13550-016-0168-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835428PMC
April 2016

High circulating activin A level is associated with tumor progression and predicts poor prognosis in lung adenocarcinoma.

Oncotarget 2016 Mar;7(12):13388-99

Translational Thoracic Oncology Laboratory, Division of Thoracic Surgery, Department of Surgery, Comprehensive Cancer Center Vienna, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.18632/oncotarget.7796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924649PMC
March 2016

New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs.

Authors:
Dominik Sturm Brent A Orr Umut H Toprak Volker Hovestadt David T W Jones David Capper Martin Sill Ivo Buchhalter Paul A Northcott Irina Leis Marina Ryzhova Christian Koelsche Elke Pfaff Sariah J Allen Gnanaprakash Balasubramanian Barbara C Worst Kristian W Pajtler Sebastian Brabetz Pascal D Johann Felix Sahm Jüri Reimand Alan Mackay Diana M Carvalho Marc Remke Joanna J Phillips Arie Perry Cynthia Cowdrey Rachid Drissi Maryam Fouladi Felice Giangaspero Maria Łastowska Wiesława Grajkowska Wolfram Scheurlen Torsten Pietsch Christian Hagel Johannes Gojo Daniela Lötsch Walter Berger Irene Slavc Christine Haberler Anne Jouvet Stefan Holm Silvia Hofer Marco Prinz Catherine Keohane Iris Fried Christian Mawrin David Scheie Bret C Mobley Matthew J Schniederjan Mariarita Santi Anna M Buccoliero Sonika Dahiya Christof M Kramm André O von Bueren Katja von Hoff Stefan Rutkowski Christel Herold-Mende Michael C Frühwald Till Milde Martin Hasselblatt Pieter Wesseling Jochen Rößler Ulrich Schüller Martin Ebinger Jens Schittenhelm Stephan Frank Rainer Grobholz Istvan Vajtai Volkmar Hans Reinhard Schneppenheim Karel Zitterbart V Peter Collins Eleonora Aronica Pascale Varlet Stephanie Puget Christelle Dufour Jacques Grill Dominique Figarella-Branger Marietta Wolter Martin U Schuhmann Tarek Shalaby Michael Grotzer Timothy van Meter Camelia-Maria Monoranu Jörg Felsberg Guido Reifenberger Matija Snuderl Lynn Ann Forrester Jan Koster Rogier Versteeg Richard Volckmann Peter van Sluis Stephan Wolf Tom Mikkelsen Amar Gajjar Kenneth Aldape Andrew S Moore Michael D Taylor Chris Jones Nada Jabado Matthias A Karajannis Roland Eils Matthias Schlesner Peter Lichter Andreas von Deimling Stefan M Pfister David W Ellison Andrey Korshunov Marcel Kool

Cell 2016 Feb;164(5):1060-1072

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.

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http://www.cell.com/cell/pdf/S0092-8674(16)00055-6.pdf
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http://www.cell.com/cms/attachment/2048488015/2058390163/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S009286741600055
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http://dx.doi.org/10.1016/j.cell.2016.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139621PMC
February 2016

Active vitamin D potentiates the anti-neoplastic effects of calcium in the colon: A cross talk through the calcium-sensing receptor.

J Steroid Biochem Mol Biol 2016 Jan 7;155(Pt B):231-8. Epub 2015 Mar 7.

Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2015.02.006DOI Listing
January 2016

Effect of 1,25-dihydroxyvitamin D3 on the Wnt pathway in non-malignant colonic cells.

J Steroid Biochem Mol Biol 2016 Jan 14;155(Pt B):224-30. Epub 2015 Mar 14.

Department of Pathophysiology and Allergy Research, Comprehensive Cancer Center, Medical University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2015.02.011DOI Listing
January 2016

Fibroblast growth factor receptor 3 isoforms: Novel therapeutic targets for hepatocellular carcinoma?

Hepatology 2015 Dec 16;62(6):1767-78. Epub 2015 Oct 16.

Department of Medicine I, Division: Institute of Cancer Research, Comprehensive Cancer Center Vienna, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1002/hep.28023DOI Listing
December 2015

EGFR is not a major driver for osteosarcoma cell growth in vitro but contributes to starvation and chemotherapy resistance.

J Exp Clin Cancer Res 2015 Nov 2;34:134. Epub 2015 Nov 2.

Institute of Cancer Research and Comprehensive Cancer Center, Department of Medicine I, Medical University Vienna, Borschkegasse 8a, 1090, Vienna, Austria.

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http://dx.doi.org/10.1186/s13046-015-0251-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630894PMC
November 2015

Sphaeropsidin A shows promising activity against drug-resistant cancer cells by targeting regulatory volume increase.

Cell Mol Life Sci 2015 Oct 14;72(19):3731-46. Epub 2015 Apr 14.

Laboratoire de Cancérologie et de Toxicologie Expérimentale, Faculté de Pharmacie, Université Libre de Bruxelles (ULB), Campus de la Plaine, Boulevard du Triomphe, 1050, Brussels, Belgium.

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http://dx.doi.org/10.1007/s00018-015-1902-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943577PMC
October 2015

Prognostic quality of activating TERT promoter mutations in glioblastoma: interaction with the rs2853669 polymorphism and patient age at diagnosis.

Neuro Oncol 2015 Sep 13;17(9):1231-40. Epub 2015 Feb 13.

Department of Neurosurgery, Wagner-Jauregg Hospital, Linz, Austria (S.S.-K., M.L., A.O.); Institute of Pathology and Neuropathology, Wagner-Jauregg Hospital, Linz, Austria (S.W.); Department of Internal Medicine, Wagner-Jauregg Hospital, Linz, Austria (J.P.); Institute of Cancer Research and Comprehensive Cancer Center-Central Nervous System Tumors Unit, Department of Medicine I, Medical University of Vienna, Vienna, Austria (D.L., C.P., T.M., W.B.); Division of Thoracic Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria (B.G.); Laboratory of Molecular Biology and Tumorcytogenetics, Hospital Barmherzige Schwestern, Linz, Austria (G.W.).

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http://dx.doi.org/10.1093/neuonc/nov010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588753PMC
September 2015

Distinct Epidemiology and Clinical Consequence of Classic Versus Rare EGFR Mutations in Lung Adenocarcinoma.

J Thorac Oncol 2015 May;10(5):738-46

*Department of Tumor Biology, National Koranyi Institute of Pulmonology, Budapest, Hungary; †Translational Thoracic Oncology Laboratory, Division of Thoracic Surgery, Department of Surgery, Comprehensive Cancer Center, Medical University of Vienna, Austria; ‡Department of Thoracic Surgery, National Institute of Oncology-Semmelweis University; §Department of Pulmonology, ‖Second Department of Pathology, Semmelweis University; ¶Molecular Oncology Research Group, Hungarian Academy of Sciences-Semmelweis University, Budapest, Hungary; #First Department of Pathology, Experimental Cancer Research, Semmelweis University, Budapest, Hungary; and ** Department of Internal Medicine I, Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, Austria.

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http://dx.doi.org/10.1097/JTO.0000000000000492DOI Listing
May 2015

Structure-Related Mode-of-Action Differences of Anticancer Organoruthenium Complexes with β-Diketonates.

J Med Chem 2015 May 17;58(9):3984-96. Epub 2015 Apr 17.

†Faculty of Chemistry and Chemical Technology, University of Ljubljana, Večna pot 113, SI-1000 Ljubljana, Slovenia.

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http://pubs.acs.org/doi/10.1021/acs.jmedchem.5b00288
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http://dx.doi.org/10.1021/acs.jmedchem.5b00288DOI Listing
May 2015

The naturally born fusariotoxin enniatin B and sorafenib exert synergistic activity against cervical cancer in vitro and in vivo.

Biochem Pharmacol 2015 Feb 31;93(3):318-331. Epub 2014 Dec 31.

Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, and Comprehensive Cancer Center of the Medical University, Borschkegasse 8a, 1090 Vienna, Austria, as well as Research Platform "Translational Cancer Therapy Research", Vienna, Austria.

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https://linkinghub.elsevier.com/retrieve/pii/S00062952140072
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http://dx.doi.org/10.1016/j.bcp.2014.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379350PMC
February 2015

Tumor-targeting of EGFR inhibitors by hypoxia-mediated activation.

Angew Chem Int Ed Engl 2014 Nov 30;53(47):12930-12935. Epub 2014 Jul 30.

Institute of Inorganic Chemistry, University of Vienna, Waehringer Strasse 42, 1090 Vienna (Austria); Research Platform "Translational Cancer Therapy Research", University of Vienna and Medical University of Vienna, Vienna (Austria).

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http://dx.doi.org/10.1002/anie.201403936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336855PMC
November 2014

Calpain-mediated integrin deregulation as a novel mode of action for the anticancer gallium compound KP46.

Mol Cancer Ther 2014 Oct 31;13(10):2436-49. Epub 2014 Jul 31.

Department of Medicine I, Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria. Institute of Inorganic Chemistry and Research Platform "Translational Cancer Therapy Research," University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1158/1535-7163.MCT-14-0087DOI Listing
October 2014