Walburga Engel-Riedel

Genomic Profiling Identifies Outcome-Relevant Mechanisms of Innate and Acquired Resistance to Third-Generation Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Therapy in Lung Cancer.

JCO Precis Oncol 2019 27;3. Epub 2019 Mar 27.

University Hospital of Cologne, Cologne, Germany.

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March 2019

Overcoming EGFR-mediated osimertinib resistance through unique binding characteristics of second-generation EGFR inhibitors.

Nat Commun 2018 11 7;9(1):4655. Epub 2018 Nov 7.

Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.

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November 2018

Large cell neuroendocrine lung carcinoma induces peripheral T-cell repertoire alterations with predictive and prognostic significance.

Authors:

Petros Christopoulos Marc A Schneider Farastuk Bozorgmehr Jonas Kuon Walburga Engel-Riedel Jens Kollmeier Volker Baum Thomas Muley Philipp A Schnabel Helge Bischoff Christian Grohé Monika Serke Michael Thomas Paul Fisch Michael Meister

Lung Cancer 2018 05 6;119:48-55. Epub 2018 Mar 6.

Translational Research Unit, Thoraxklinik at Heidelberg University Hospital, Germany; Translational Lung Research Center Heidelberg (TLRC-H), Heidelberg, Member of the German Center for Lung Research (DZL), Germany.

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May 2018

A randomized, controlled trial evaluating the efficacy and safety of BTH1677 in combination with bevacizumab, carboplatin, and paclitaxel in first-line treatment of advanced non-small cell lung cancer.

Authors:

Walburga Engel-Riedel Jamie Lowe Paulette Mattson J Richard Trout Richard D Huhn Michele Gargano Myra L Patchen Richard Walsh My My Trinh Mariève Dupuis Folker Schneller

J Immunother Cancer 2018 02 27;6(1):16. Epub 2018 Feb 27.

Medical Clinic and Polyclinic of Klinikum rechts der Isar of Technical University Munich, Ismaninger Str. 22, 81675, Munich, Germany.

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February 2018

65Plus: open-label study of bevacizumab in combination with pemetrexed or pemetrexed/carboplatin as first-line treatment of patients with advanced or recurrent nonsquamous non-small-cell lung cancer.

Authors:

Wolfgang Schuette Claus-Peter Schneider Walburga Engel-Riedel Christian Schumann Martin Kohlhaeufl Monika Heidi Ursel Serke Gert Hoeffken Cornelius Kortsik Martin Reck

Lung Cancer (Auckl) 2017 6;8:217-229. Epub 2017 Nov 6.

Department of Thoracic Oncology, Lung Clinic, Grosshansdorf, Germany.

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November 2017

[Trimodal Therapy for Stage IIIA-B NSCLC Involving High Dose Neoadjuvant Chemoradiotherapy. Is Surgery a Rational Option?]

Authors:

Aris Koryllos Corinna Ludwig Walburga Engel-Riedel Michaela Hammer-Helmig Erich Stoelben

Zentralbl Chir 2017 Sep 28;142(S 01):S26-S32. Epub 2017 Sep 28.

Klinik für Thoraxchirurgie, Lungenklinik Köln-Merheim, Lehrstuhl für Thoraxchirurgie Universität Witten Herdecke, Kliniken der Stadt Köln gGmbH, Deutschland.

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September 2017

The (Con-) Fusion in ALK Diagnostics: When Food and Drug Administration-Approved Algorithms Fail.

Authors:

Jessica Jürgens Walburga Engel-Riedel Erich Stoelben Verena Schildgen Oliver Schildgen Michael Brockmann

J Clin Oncol 2016 06 25;34(16):1961-2. Epub 2016 Apr 25.

Kliniken der Stadt Köln, Klinikum der Privaten Universität Witten/Herdecke mit Sitz in Köln, Köln, Germany

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June 2016

GILT--A randomised phase III study of oral vinorelbine and cisplatin with concomitant radiotherapy followed by either consolidation therapy with oral vinorelbine and cisplatin or best supportive care alone in stage III non-small cell lung cancer.

Authors:

Michael Flentje Rudolf M Huber Walburga Engel-Riedel Stefan Andreas Jens Kollmeier Susanne Staar Nicolas Dickgreber Nathalie Vaissiere Cecilia De Almeida Birgit Edlich Rainer Fietkau

Strahlenther Onkol 2016 Apr 25;192(4):216-22. Epub 2016 Jan 25.

University Hospital Erlangen, Erlangen, Germany.

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April 2016

A randomized Phase 2 study of pemetrexed in combination with cisplatin or carboplatin as adjuvant chemotherapy in patients with completely resected stage IB or II Non-Small-Cell Lung Cancer.

Authors:

Gerald Schmid-Bindert Walburga Engel-Riedel Martin Reck Wolfgang Schuette Jan Stöhlmacher Jürgen R Fischer Julien Mazières Christos Chouaid Martin Wolf Nuria Vinolas Victoria Soldatenkova Veronique Ripoche Tuan Nguyen Carla Visseren-Grul

Lung Cancer 2015 Dec 7;90(3):397-404. Epub 2015 Nov 7.

Lilly Oncology Europe, Grootslag 1-5, Houten, the Netherlands. Electronic address:

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December 2015

Molecular Pathology and Personalized Medicine: The Dawn of a New Era in Companion Diagnostics-Practical Considerations about Companion Diagnostics for Non-Small-Cell-Lung-Cancer.

Authors:

Till Plönes Walburga Engel-Riedel Erich Stoelben Christina Limmroth Oliver Schildgen Verena Schildgen

J Pers Med 2016 Jan 15;6(1). Epub 2016 Jan 15.

Institute for Pathology, Hospital of Cologne, Private University Witten/Herdecke, Ostmerheimerstrasse 200, 51109 Köln, Germany.

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January 2016

Clinicopathological Characteristics of RET Rearranged Lung Cancer in European Patients.

J Thorac Oncol 2016 Jan;11(1):122-7

Center for Integrated Oncology Köln Bonn, Cologne, Germany; Lung Cancer Group Cologne, Department I for Internal Medicine, University Hospital of Cologne, Cologne, Germany; Network Genomic Medicine, Cologne, Germany. Electronic address:

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January 2016

Three-Year Follow-Up of a Randomized Phase II Trial on Refinement of Early-Stage NSCLC Adjuvant Chemotherapy with Cisplatin and Pemetrexed versus Cisplatin and Vinorelbine (the TREAT Study).

Authors:

Michael Kreuter Johan Vansteenkiste Jürgen R Fischer Wilfried E Eberhardt Heike Zabeck Jens Kollmeier Monika Serke Norbert Frickhofen Martin Reck Walburga Engel-Riedel Silke Neumann Michiel Thomeer Christian Schumann Paul De Leyn Thomas Graeter Georgios Stamatis Frank Griesinger Michael Thomas

J Thorac Oncol 2016 Jan;11(1):85-93

Thoracic Oncology, Thoraxklinik, University of Heidelberg, Heidelberg, Germany; Translational Lung Research Center Heidelberg, German Center for Lung Research, Heidelberg, Germany.

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January 2016

Final results from a Phase II study of pemetrexed and cisplatin with concurrent thoracic radiation after Pem-Cis induction in patients with unresectable locally advanced non-squamous non-small cell lung cancer (NSCLC).

Authors:

Pilar Garrido Walburga Engel-Riedel Monika Serke Philippe Giraud Umberto Ricardi Carmen Vallejo Carla Visseren-Grul Sophie Ameryckx Victoria Soldatenkova Nadia Chouaki Silvia Novello

Lung Cancer 2015 May 23;88(2):160-6. Epub 2015 Feb 23.

Department of Oncology, University of Turin, S. Luigi Hospital, Orbassano (TO), Italy.

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May 2015

MET amplification status in therapy-naïve adeno- and squamous cell carcinomas of the lung.

Clin Cancer Res 2015 Feb 9;21(4):907-15. Epub 2014 Dec 9.

Institute of Pathology, University Hospital Cologne, Cologne, Germany. Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany. Targos Molecular Pathology, Kassel, Germany.

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February 2015

PIK3CA mutations in non-small cell lung cancer (NSCLC): genetic heterogeneity, prognostic impact and incidence of prior malignancies.

Oncotarget 2015 Jan;6(2):1315-26

Center for Integrated Oncology Köln Bonn, Cologne, Germany.Lung Cancer Group Cologne, Department I for Internal Medicine, University Hospital of Cologne, Cologne, Germany.

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January 2015

Absence of amplification of the FGFR1-gene in human malignant mesothelioma of the pleura: a pilot study.

Authors:

Till Plönes Frank Beckers Walburga Engel-Riedel Erich Stoelben Michael Brockmann Verena Schildgen Oliver Schildgen

BMC Res Notes 2014 Aug 19;7:549. Epub 2014 Aug 19.

Department of Thoracic Surgery, University Medical Center Witten/Herdecke, Lung Clinic Merheim, Campus Cologne, Ostmerheimerstrasse 200, 51109 Köln, Germany.

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August 2014

Combined point mutation in KRAS or EGFR genes and EML4-ALK translocation in lung cancer patients.

Authors:

Jessica Jürgens Walburga Engel-Riedel Alexander Prickartz Corinna Ludwig Oliver Schildgen Ramona-Liza Tillmann Erich Stoelben Michael Brockmann Verena Schildgen

Future Oncol 2014 Mar;10(4):529-32

Lungenklinik, Kliniken der Stadt Köln gGmbH, Klinikum der Privaten Universität Witten Herdecke mit Sitz in Köln.

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March 2014

Combination of Pyrosequencing and Sanger sequencing reveals alleged novel mutation in exon 18 of EGFR.

Authors:

Verena Schildgen Carolin Schulz Jessica Lüsebrink Ramona-Liza Tillmann Walburga Engel-Riedel Erich Stoelben Oliver Schildgen Michael Brockmann

Per Med 2013 Mar;10(2):201-209

Institut für Pathologie, Kliniken der Stadt Köln gGmbH, Krankenhaus Merheim, Klinikum der Privaten Universität Witten/Herdecke, Institut für Pathologie, Ostmerheimer Str. 200, D-51109 Köln (Cologne), Germany.

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March 2013

Identification of uncommon PIK3CA mutations in lung cancer by using pyrosequencing.

Authors:

Verena Schildgen Jessica Lüsebrink Jan D Appel Christine Wübben Walburga Engel-Riedel Corinna Ludwig Erich Stoelben Oliver Schildgen Michael Brockmann

Diagn Mol Pathol 2013 Mar;22(1):22-7

Institut für Pathologie, Kliniken der Stadt Köln gGmbH, Köln, Germany.

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March 2013

Prognostic impact of [18F]fluorothymidine and [18F]fluoro-D-glucose baseline uptakes in patients with lung cancer treated first-line with erlotinib.

Authors:

Matthias Scheffler Thomas Zander Lucia Nogova Carsten Kobe Deniz Kahraman Markus Dietlein Irini Papachristou Lukas Heukamp Reinhard Büttner Ron Boellaard Adriaan A Lammertsma Silvia Querings Erich Stoelben Walburga Engel-Riedel Bernd Neumaier Jürgen Wolf

PLoS One 2013 4;8(1):e53081. Epub 2013 Jan 4.

Department I for Internal Medicine, University Hospital of Cologne, Cologne, Germany.

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July 2013

Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing.

Cell 2012 Sep;150(6):1107-20

Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, MA 02142, USA.

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September 2012

Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer.

Authors:

Martin Peifer Lynnette Fernández-Cuesta Martin L Sos Julie George Danila Seidel Lawryn H Kasper Dennis Plenker Frauke Leenders Ruping Sun Thomas Zander Roopika Menon Mirjam Koker Ilona Dahmen Christian Müller Vincenzo Di Cerbo Hans-Ulrich Schildhaus Janine Altmüller Ingelore Baessmann Christian Becker Bram de Wilde Jo Vandesompele Diana Böhm Sascha Ansén Franziska Gabler Ines Wilkening Stefanie Heynck Johannes M Heuckmann Xin Lu Scott L Carter Kristian Cibulskis Shantanu Banerji Gad Getz Kwon-Sik Park Daniel Rauh Christian Grütter Matthias Fischer Laura Pasqualucci Gavin Wright Zoe Wainer Prudence Russell Iver Petersen Yuan Chen Erich Stoelben Corinna Ludwig Philipp Schnabel Hans Hoffmann Thomas Muley Michael Brockmann Walburga Engel-Riedel Lucia A Muscarella Vito M Fazio Harry Groen Wim Timens Hannie Sietsma Erik Thunnissen Egbert Smit Daniëlle A M Heideman Peter J F Snijders Federico Cappuzzo Claudia Ligorio Stefania Damiani John Field Steinar Solberg Odd Terje Brustugun Marius Lund-Iversen Jörg Sänger Joachim H Clement Alex Soltermann Holger Moch Walter Weder Benjamin Solomon Jean-Charles Soria Pierre Validire Benjamin Besse Elisabeth Brambilla Christian Brambilla Sylvie Lantuejoul Philippe Lorimier Peter M Schneider Michael Hallek William Pao Matthew Meyerson Julien Sage Jay Shendure Robert Schneider Reinhard Büttner Jürgen Wolf Peter Nürnberg Sven Perner Lukas C Heukamp Paul K Brindle Stefan Haas Roman K Thomas

Nat Genet 2012 Oct 2;44(10):1104-10. Epub 2012 Sep 2.

Department of Translational Genomics, University of Cologne, Cologne, Germany.

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October 2012

Definition of a fluorescence in-situ hybridization score identifies high- and low-level FGFR1 amplification types in squamous cell lung cancer.

Mod Pathol 2012 Nov 8;25(11):1473-80. Epub 2012 Jun 8.

Centre of Integrated Oncology Köln-Bonn, Institute of Pathology, University Hospital Cologne, Cologne, Germany.

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November 2012

Benchmarking of mutation diagnostics in clinical lung cancer specimens.

PLoS One 2011 May 5;6(5):e19601. Epub 2011 May 5.

Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Cologne, Germany.

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May 2011

Blood-based gene expression signatures in non-small cell lung cancer.

Authors:

Thomas Zander Andrea Hofmann Andrea Staratschek-Jox Sabine Classen Svenja Debey-Pascher Daniela Maisel Sascha Ansén Moritz Hahn Marc Beyer Roman K Thomas Birgit Gathof Cornelia Mauch Karl-Stefan Delank Walburga Engel-Riedel H-Erich Wichmann Erich Stoelben Joachim L Schultze Jürgen Wolf

Clin Cancer Res 2011 May 10;17(10):3360-7. Epub 2011 May 10.

Department I of Internal Medicine, University Hospital Cologne, Cologne, Germany.

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May 2011

Early prediction of nonprogression in advanced non-small-cell lung cancer treated with erlotinib by using [(18)F]fluorodeoxyglucose and [(18)F]fluorothymidine positron emission tomography.

J Clin Oncol 2011 May 21;29(13):1701-8. Epub 2011 Mar 21.

Department I of Internal Medicine, Center for Integrated Oncology Köln Bonn, University Hospital of Cologne, 50924 Cologne, Germany.

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May 2011

Addition of darbepoetin alfa to dose-dense chemotherapy: results from a randomized phase II trial in small-cell lung cancer patients receiving carboplatin plus etoposide.

Authors:

Sylke Nagel Olaf Kellner Walburga Engel-Riedel Sylvia Guetz Christian Schumann Frank Gieseler Wolfgang Schuette

Clin Lung Cancer 2011 Jan;12(1):62-9

Hospital Martha-Maria, Halle-Doelau, Germany.

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January 2011

Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer.

Authors:

Jonathan Weiss Martin L Sos Danila Seidel Martin Peifer Thomas Zander Johannes M Heuckmann Roland T Ullrich Roopika Menon Sebastian Maier Alex Soltermann Holger Moch Patrick Wagener Florian Fischer Stefanie Heynck Mirjam Koker Jakob Schöttle Frauke Leenders Franziska Gabler Ines Dabow Silvia Querings Lukas C Heukamp Hyatt Balke-Want Sascha Ansén Daniel Rauh Ingelore Baessmann Janine Altmüller Zoe Wainer Matthew Conron Gavin Wright Prudence Russell Ben Solomon Elisabeth Brambilla Christian Brambilla Philippe Lorimier Steinar Sollberg Odd Terje Brustugun Walburga Engel-Riedel Corinna Ludwig Iver Petersen Jörg Sänger Joachim Clement Harry Groen Wim Timens Hannie Sietsma Erik Thunnissen Egbert Smit Daniëlle Heideman Federico Cappuzzo Claudia Ligorio Stefania Damiani Michael Hallek Rameen Beroukhim William Pao Bert Klebl Matthias Baumann Reinhard Buettner Karen Ernestus Erich Stoelben Jürgen Wolf Peter Nürnberg Sven Perner Roman K Thomas

Sci Transl Med 2010 Dec;2(62):62ra93

Max Planck Institute for Neurological Research, Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, 50931 Cologne, Germany.

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December 2010