Wakako Takabe

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Wakako Takabe

Publications by authors named "Wakako Takabe"

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28Publications

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Esterification of 24S-OHC induces formation of atypical lipid droplet-like structures, leading to neuronal cell death.

J Lipid Res 2016 11 19;57(11):2005-2014. Epub 2016 Sep 19.

Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, Kyoto 610-0394, Japan

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November 2016

Synthesis of 24(S)-hydroxycholesterol esters responsible for the induction of neuronal cell death.

Bioorg Med Chem 2016 06 12;24(11):2559-66. Epub 2016 Apr 12.

Department of Molecular Chemistry and Biochemistry, Faculty of Sciences and Technology, Doshisha University, 1-3 Miyakodani, Tatara, Kyotanabe, Kyoto 610-0394, Japan.

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June 2016

Disturbed flow enhances inflammatory signaling and atherogenesis by increasing thioredoxin-1 level in endothelial cell nuclei.

PLoS One 2014 29;9(9):e108346. Epub 2014 Sep 29.

Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University, Atlanta, Georgia, United States of America.

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November 2015

Lysophosphatidylcholine promotes SREBP-2 activation via rapid cholesterol efflux and SREBP-2-independent cytokine release in human endothelial cells.

J Biochem 2015 Oct 21;158(4):331-8. Epub 2015 May 21.

Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, Kyoto 610-0321, Japan; and

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October 2015

New aspects of 24(S)-hydroxycholesterol in modulating neuronal cell death.

Free Radic Biol Med 2015 Oct 9;87:366-72. Epub 2015 Jul 9.

Systems Life Sciences Laboratory, Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe, Kyoto 610-0394, Japan.

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October 2015

24(S)-Hydroxycholesterol induces RIPK1-dependent but MLKL-independent cell death in the absence of caspase-8.

Steroids 2015 Jul 16;99(Pt B):230-7. Epub 2015 Feb 16.

Systems Life Sciences Laboratory, Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, 1-3 Miyakodani, Tatara, Kyotanabe, Kyoto 610-0394, Japan. Electronic address:

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July 2015

Shear stress-activated Wnt-angiopoietin-2 signaling recapitulates vascular repair in zebrafish embryos.

Arterioscler Thromb Vasc Biol 2014 Oct 21;34(10):2268-75. Epub 2014 Aug 21.

From the Department of Medicine, School of Medicine (R.L., T.K.H.), Department of Bioengineering (T.B., N.J., F.Y., W.T., H.C., J.L., T.K.H.), and Department of Molecular, Cell, and Developmental Biology (K.W., H.S., J.C.), University of California, Los Angeles; Department of Surgery, Children's Hospital Los Angeles, CA (M.H., C.-L.L.); and Division of Cardiology, Department of Medicine, School of Medicine (H.Y., P.H., N.C.C.) and Institute of Genomic Medicine (N.C.C.), University of California, San Diego, La Jolla.

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October 2014

The atypical mechanosensitive microRNA-712 derived from pre-ribosomal RNA induces endothelial inflammation and atherosclerosis.

Nat Commun 2013 ;4:3000

1] Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 30322, USA [2] Division of Cardiology, Department of Medicine, Emory University, Atlanta, Georgia 30322, USA [3] Department of Bioinspired Science, Ewha Womans University, Seoul 120-750, South Korea.

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July 2014

Oscillatory shear stress induces mitochondrial superoxide production: implication of NADPH oxidase and c-Jun NH2-terminal kinase signaling.

Antioxid Redox Signal 2011 Sep 14;15(5):1379-88. Epub 2011 Apr 14.

Department of Biomedical Engineering and Cardiovascular Medicine, University of Southern California, Los Angeles, California 90089, USA.

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September 2011

Anti-atherogenic effect of laminar shear stress via Nrf2 activation.

Antioxid Redox Signal 2011 Sep 21;15(5):1415-26. Epub 2011 Apr 21.

Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.

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September 2011

Disturbed flow: p53 SUMOylation in the turnover of endothelial cells.

J Cell Biol 2011 May;193(5):805-7

Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30322, USA.

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May 2011

Electrocardiogram signals to assess zebrafish heart regeneration: implication of long QT intervals.

Ann Biomed Eng 2010 Jul 11;38(7):2346-57. Epub 2010 Mar 11.

Department of Biomedical Engineering and Division of Cardiovascular Medicine, University of Southern California, Los Angeles, CA 90089, USA.

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July 2010

Oxidized low-density lipoprotein-activated c-Jun NH2-terminal kinase regulates manganese superoxide dismutase ubiquitination: implication for mitochondrial redox status and apoptosis.

Arterioscler Thromb Vasc Biol 2010 Mar 5;30(3):436-41. Epub 2010 Feb 5.

Department of Biomedical Engineering and Division of Cardiovascular Medicine, School of Medicine and School of Engineering, University of Southern California, 1042 Downey Way, Los Angeles, CA 90089, USA.

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March 2010

Pulsatile shear stress increased mitochondrial membrane potential: implication of Mn-SOD.

Biochem Biophys Res Commun 2009 Oct 8;388(2):406-12. Epub 2009 Aug 8.

Department of Biomedical Engineering and Division of Cardiovascular Medicine, University of Southern California, Los Angeles, CA, USA.

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October 2009

Optimization of intravascular shear stress assessment in vivo.

J Biomech 2009 Jul 19;42(10):1429-37. Epub 2009 May 19.

Department of Biomedical Engineering and Cardiovascular Medicine, University of Southern California, Los Angeles, CA 90089-1111, USA.

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July 2009

Ultrafine particles from diesel engines induce vascular oxidative stress via JNK activation.

Free Radic Biol Med 2009 Mar 11;46(6):775-82. Epub 2008 Dec 11.

Department of Biomedical Engineering and Division of Cardiovascular Medicine, University of Southern California, Los Angeles, CA 90089, USA.

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March 2009

Monitoring oxidative stress in vascular endothelial cells in response to fluid shear stress: from biochemical analyses to micro- and nanotechnologies.

Methods Enzymol 2008 ;441:111-50

Department of Biomedical Engineering, School of Engineering, University of Southern California, Los Angeles, CA, USA.

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August 2008

Shear stress influences spatial variations in vascular Mn-SOD expression: implication for LDL nitration.

Am J Physiol Cell Physiol 2008 Jun 23;294(6):C1576-85. Epub 2008 Apr 23.

Department of Biomedical Engineering and Cardiovascular Medicine, University of Southern California, Los Angeles, CA 90089, USA.

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June 2008

Shear stress stabilizes NF-E2-related factor 2 and induces antioxidant genes in endothelial cells: role of reactive oxygen/nitrogen species.

Free Radic Biol Med 2007 Jan 20;42(2):260-9. Epub 2006 Oct 20.

Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology (LSBM), University of Tokyo, 4-6-1, Komaba, Meguro, Tokyo 153-8904, Japan.

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January 2007

Chemical structure-dependent gene expression of proteasome subunits via regulation of the antioxidant response element.

Free Radic Res 2006 Jan;40(1):21-30

Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, 4-6-1 Komaba, Meguro, Japan.

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January 2006

Inhibition of cholesterol biosynthesis by 25-hydroxycholesterol is independent of OSBP.

Genes Cells 2005 Aug;10(8):793-801

Graduate School of Pharmaceutical Sciences, University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.

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August 2005

Expression of the LXRalpha protein in human atherosclerotic lesions.

Arterioscler Thromb Vasc Biol 2005 Mar 29;25(3):622-7. Epub 2004 Dec 29.

Department of Systems Biology and Medicine, Research Center for Advanced Science and Technology, the University of Tokyo, Japan.

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March 2005

Global analysis of RNA expression profile in human vascular cells treated with statins.

J Atheroscler Thromb 2004 ;11(2):62-72

Laboratory for Systems Biology and Medicine, RCAST, University of Tokyo, #35, 4-6-1 Komaba, Meguro, Tokyo 153-8904, Japan.

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February 2005

Lysophosphatidylcholine enhances cytokine production of endothelial cells via induction of L-type amino acid transporter 1 and cell surface antigen 4F2.

Arterioscler Thromb Vasc Biol 2004 Sep 3;24(9):1640-5. Epub 2004 Jun 3.

Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro, Tokyo, 153-8904, Japan.

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September 2004